Allen Institute jobs - 29 jobs

Scientific Project and Alliance Manager Scientific Operations The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. The mission of the Neural Dynamics division of the Allen Institute is to answer fundamental questions about brain function. Specifically, how does our brain build our understanding of the complex world around us to guide the flexible behaviors that address our biological needs? The Neural Dynamics division of the Allen Institute is seeking a Scientific Project and Alliance Manager. We are looking for a team player to drive ground-breaking systems neuroscience projects in collaboration with partners across the world. This leader will use strong interpersonal and collaboration skills to navigate challenging group dynamics and work effectively across scientific, technical, and business interfaces. The Scientific Project and Alliance Manager will provide the operational structure necessary for a multi-disciplinary, international team to make discoveries based on mapping brain-wide neural circuits using cutting-edge optical imaging and neurophysiology. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Drive, coordinate, and support the scientific goals of AIND projects * Create, maintain, and disseminate project deliverables and timelines, using project management best practices and tools * Ensure the successful execution of project deliverables by working with cross-functional teams through planning and execution phases * Work with Project Coordinators to support the scientific and dissemination goals of the projects * Provide an efficient and nimble collaborative environment to manage internal and external project team communication and collaboration * Ensure fiscal management of the project * Organize internal and external project reviews * Develop applications for external funding * Facilitate efficient communication between scientific and administrative groups * Work with the Scientific Program team to develop project management best practices Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned. Required Education and Experience * PhD in biological sciences, with a strong preference towards neuroscience domain knowledge; or an equivalent combination of degree and experience * 1 year of project management experience in a scientific or technical environment Preferred Education and Experience * PhD degree in biology, neuroscience, biomedical science, or equivalent combination of degree and experience * 5+ years of experience in project management, beyond an academic laboratory/postdoctoral setting * Formal project management training and/or PMP certification * Experience navigating complex group dynamics, and working with scientific, engineering and administrative stakeholders * Demonstrated ability to multitask amongst multiple projects simultaneously * Advanced ability to translate scientific and technical subject matter into concise, clear communications that are understood by technical and non-technical leaders and constituents * Experience with competitive external funding applications (federal and private) including familiarity with the budget process and relevant compliance and post-award reporting requirements * Working knowledge in neuroscience, in vivo neurophysiology, databases, Python programming Physical Demands * Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with lab equipment Position Type/Expected Hours of Work * This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N., with flexibility to work remotely on a limited basis. We are a Washington State employer; any remote work must be performed in Washington State. Travel * Attendance and participation in national and/or international conferences may be required Additional Comments * Please note, this opportunity offers relocation assistance * Please note, this opportunity may offer work visa sponsorship Annual Salary Range * $119,650 - $149,550 * * Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable. Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institute's Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. Join the Seattle Hub for Synthetic Biology (SeaHub), a new initiative at the intersection of academic creativity and start-up style execution. Our mission is to reimagine living cells and genomes as devices for recording biology and diagnostic information over time, as well as for encoding real-time therapeutic decision-making. Take off with us as we imagine and create a kind of cellular flight recorder that can also seize the controls. Be part of a small dynamic team on the ground floor of a new program with world-class scientists. SeaHub is looking for a Scientist I, Computational Biology and Bioinformatics for the Read team. The computational biologist should have a very strong background in each of two areas: 1) next-generation genomic technology development methodology and 2) writing ad hoc and bespoke bioinformatics scripts in Python and R to do detailed bioinformatics analyses of next-generation sequencing data. The role will include leading the effort to process and analyze large amounts of diverse sets of sequencing data (both short-read and long-read) to draw conclusions from wet lab experiments, in close collaboration with teams focused on expanding our abilities to engineer cells and genomes to autonomously Write, Sense, and Act at a molecular level. The successful candidate will play a key role in advancing our ability to record lineage and signaling information in the genomes of mammalian cells. This position requires a collaborative mindset, timeline-management abilities, and the ability to work cross-functionally with other research teams to drive project success. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Develop next-generation sequencing analysis scripts and pipelines that run on cloud-based architectures (CodeOcean, AWS) * Manage cloud-based data transfer and storage on AWS and other cloud-based servers * Independently perform in-depth bioinformatics analyses on generated sequencing data from wet lab experiments and work with experimental teams to guide project direction * Develop and disseminate written reports summarizing data processing and analysis results and findings with a reasonable turnaround time * Develop bespoke computational biology tools and bioinformatics scripts as needed to advance internal research projects * Follow industry software development and bioinformatics best practices - participate in code reviews, version code, track issues, and write proper documentation * Troubleshoot technical barriers to progress in the reading of synthetic records * Maintain a detailed electronic notebook and create presentations to summarize progress and frame internal decision-making * Mentor and motivate others to perform the above functions Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned. Required Experience and Education * PhD in genetics, genomics, computational biology, bioinformatics, or related field; or equivalent combination of education and experience * Very strong coding ability in R and python Preferred Education and Experience * 0 5 years relevant post-doc experience * Expertise in functional genomics and screening, single cell genomics, synthetic biology, or related domains, including demonstrated mastery of molecular biology * Track record of working as part of a team and understanding the importance of team dynamics * Understanding how data is generated from wet lab experiments in a molecular biology / cell culture laboratory * Expertise with AWS and CodeOcean cloud computing * Outstanding scientific achievement * Experience with molecular biology, mammalian cell culture, stem cell culture, developmental biology or immunology, genomics, and mouse genetics * Experience with lineage tracing algorithm development * Excellent written and verbal communication skills * Strong project management and organizational skills * Excellent analytical and problem-solving skills combined with capacity for complex, detail-oriented work Physical Demands * Fine motor movements in fingers/hands to operate computers and other office equipment Position Type/Expected Hours of Work * This role is currently working onsite and is expected to work onsite for the majority of the working hours. We are a Washington State employer, and the primary work location for Allen Institute employees is 700 Dexter Ave N.; any remote work must be performed in Washington State. Travel * The successful applicant may be invited to attend occasional national and international conferences Additional Comments * Please note, this opportunity offers relocation assistance * Please note, this opportunity may offer work visa sponsorship Annualized Salary Range * $92,250 - $114,100 * * Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable. Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

Scientist I ML/AI algorithms for Multimodal Foundational Models Human Cell Types The mission of the Allen Institute is to understand the principles that govern life, and to advance health. Our creative and multi-dimensional teams focus on answering some of the biggest questions in bioscience. We accelerate foundational research, catalyze bold ideas, develop tools and models, and openly share our science to make a broad, transformational impact on the world. The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through the integration of experiments, modeling, and theory. The Seattle Alzheimers Disease Brain Cell Atlas (SEA-AD) consortium strives to achieve a deep molecular and cellular understanding of the early pathogenesis of Alzheimers disease (AD). Leveraging advances in quantitative neuropathology and next-generation single cell molecular profiling technologies we are generating large-scale data sets from well-characterized donors that span the spectrum of AD pathology to comprehensively map human brain cell types across aging and disease. These data along with tools for their use are made freely and publicly available. We seek to hire a Research Scientist position to design modern machine learning methods to integrate multimodal data, model disease trajectories from imaging data sets (MRI, PET, fMRI) and contribute to the mechanistic understanding of Alzheimers disease pathology. The successful candidate will have a strong background in computational biology, computer science, or statistics, and experience developing and training computer vision machine learning models applied to disease data. Strong preference will be given to individuals with a track record of both individual and team contributions in solving complex research problems, and experience in cutting-edge computational methodologies applied to biological -omics, spatial, and/or clinical metadata. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Conduct research, design, develop and prototype novel algorithms to model disease progression from imaging data sets * Harmonize multiple imaging data modalities into a common analysis framework * Train large-scale models in multi-GPU environments efficiently * Stay at the forefront of advances in AI for computer vision * Participate in a highly interactive and multidisciplinary environment * Publish/present findings in peer-reviewed journals/scientific conferences Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned. Required Education and Experience * Ph.D. in Computer Science, Applied Math, Engineering, Computational Neuroscience, Computational Biology, or related field, or equivalent combination of degree and experience * Experience working with recent Deep Learning Architectures/Foundational Models * Experience with building, deploying and maintaining machine learning and foundational models * Proficiency with cloud computing (AWS, GCP or Azure) and with on-prem clusters * Proven ability to work independently and manage multiple projects simultaneously while meeting deadlines * Excellent written and verbal communication skills, with the ability to collaborate effectively in a multidisciplinary team environment Preferred Education and Experience * Experience with modeling disease heterogeneity * Experience building transformer-based foundational models * Working knowledge of AI/ML custom libraries, AI/ML execution platforms * Proven track record of achieving significant results as demonstrated by grants, fellowships, as well as first-authored publications at leading workshops or conferences such as CVPR/ICCV/ECCV, NeurIPS/ICLR, ICRA/RSS/CoRL/IROS, or SIGGRAPH * Proven ability to work independently and manage multiple projects simultaneously while meeting deadlines in a highly collaborative environment * Excellent written and verbal communication skills, with the ability to collaborate effectively in a multidisciplinary team environment Physical Demands * Occasional lifting up to 30 pounds (reference: a ream of paper weighs approx. 5lbs * Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with lab equipment. Position Type/Expected Hours of Work * This role is currently able to work both remotely and onsite in a hybrid work environment. We are a Washington State employer, and the primary work location for all Allen Institute employees is 615 Westlake Ave N.; any remote work must be performed in Washington State. Travel * Occasional attendance and participation in national and international conferences Additional Comments * Please note, this opportunity offers relocation assistance * Please note, this opportunity may offer visa sponsorship Annualized Salary Range $92,250 - $114,100 * * Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable. Benefits Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. Join us on the ground floor to shape the future of programmable cell therapies. SeaBridge, a new translational incubator powered by SeaHub technology, is looking for an innovative immunologist to join our founding team. Youll help launch and shape the incubator while driving our allogeneic (off-the-shelf) CAR-T cell therapy program. Were looking for someone with deep expertise in human iPSC culture, differentiation, and genetic engineering. Youll be responsible for developing robust protocols to derive T-cell lines from iPSCs and applying cutting-edge CRISPR/Cas9 editing to enhance their therapeutic potential. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Play a founding role in creating an incubator designed to turn discoveries into cures * Shape and lead a cutting-edge allogeneic (off-the-shelf) CAR-T cell therapy program * Drive innovation at the intersection of iPSCs, CRISPR, and translational science * Develop robust protocols for deriving T-cell lines from iPSCs and for applying state-of-the-art CRISPR/Cas9 gene editing technologies to enhance their therapeutic properties * Design, execute, and analyze gene editing experiments using CRISPR/Cas9 and other technologies to modify iPSC-derived T-cells * Maintain and expand high-quality human iPSC lines in a cGMP-compliant manner * Engineer T-cells to express chimeric antigen receptors (CARs) for targeted cancer therapy * Apply genome editing to remove or insert genes to enhance T-cell potency, reduce T-cell exhaustion, or mitigate off-target toxicity (e.g., knocking out TCR to prevent Graft-vs-Host Disease) * Use multi-color flow cytometry, cell sorting, and functional assays to characterize iPSC-derived and engineered T-cells * Assess T-cell functionality, such as proliferation, cytokine production, and antigen-specific cytotoxicity * Conduct molecular characterization using techniques like dd PCR, qPCR, Sanger sequencing, and next-generation sequencing to confirm successful gene editing * Work effectively in a cross-functional team, interacting with process development, analytical development, and regulatory affairs * Document all experimental procedures and results in electronic lab notebooks and technical reports * Present data and findings at internal meetings to advance CAR-T pipeline programs Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned. Required Experience and Education * Ph.D. in Immunology, Molecular Biology, Cell Biology, Bioengineering, or a related field; or equivalent combination of education and experience * 5 years of relevant postdoctoral or industry experience or equivalent experience Preferred Education and Experience * 5 8 years relevant post-doctoral experience * Strong hands-on experience with human iPSC culture, maintenance, and differentiation protocols * Extensive practical experience with CRISPR/Cas9 or other gene editing technologies in mammalian cells * Proficiency in primary human T-cell culture and engineering is a strong plus * Expertise in multi-color flow cytometry and cell sorting for cell characterization * Experience with viral (lentivirus, AAV) and non-viral gene delivery methods * Excellent communication and interpersonal skills * Ability to work independently and as part of a collaborative, fast-paced team * Strong problem-solving and troubleshooting abilities * Demonstrated team management * Demonstrated ability to build and lead a program Physical Demands * Fine motor movements in fingers/hands to operate computers and other office equipment Work Environment * Frequently required to sit, stand, walk, stoop, kneel or reach * Possible exposure and handling of laboratory animals * Laboratory atmosphere - possible exposure to chemical, biological or other hazardous substances Position Type/Expected Hours of Work * This role is currently working onsite and is expected to work onsite for the majority of the working hours. We are a Washington State employer, and the primary work location for Allen Institute employees is 700 Dexter Ave N.; any remote work must be performed in Washington State. Travel * The successful candidate may be invited to attend occasional national and international conferences Additional Comments * Please note, this opportunity offers relocation assistance * Please note, this opportunity may offer work visa sponsorship Annualized Salary Range * $128,050 - $160,050 * * Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outline in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:?

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. As part of the Finance Team, the Grants Administrator I reports to the Associate Director, Office of Sponsored Research (OSR). This position supports all functional and technical aspects of grant management for pre- and post-award grant activities. At the Allen Institute, we believe that science is for everyoneand should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions Essential Functions * Prepares and submits standard, less complex grant and contract proposals * Drafts standard subaward agreements and amendments * Works with Grants Administrators and investigators to manage the lifecycle of research administration, including: submission of grant and contract proposals, subaward management, effort tracking, and reporting oversight * Develop and maintain systems for recording and tracking grant proposals and post-award metrics * Establish and maintain data integrity across grant management tracking and fiscal systems * Ensure records are auditable and are transitioned properly throughout the pre- and post-award process * Assist with the development of training materials and workshops to educate internal teams on successful award development and administration * Owns vendor management screening via Visual Compliance * Screens sub awardees and Institute vendors; escalates any findings to the Associate Director, OSR * Responsible for internal grant website, including developing reference guides and ensuring policies and procedures are updated to align with changes in federal agency and Institute policies or guidelines * Engage in continuous improvement initiatives at the personal, team, and Institute levels * Routinely interact with individuals at all levels within the organization, including: Investigators, program managers and Institute leadership * Remain active in professional development societies (such as SRA & NCURA) to ensure skillset is maintained and learned knowledge is shared with internal stakeholders Pre-Award Responsibilities * Grant application kick-off meetings: prepare PowerPoint slides, timelines for proposal development, task lists to assist teams with managing deliverables * Run grant kick-off meetings and maintain communication with internal and external stakeholders to ensure deadlines are met * Liaise with external institutions to collect subaward or contract materials, and serve as the primary contact for questions from external parties for proposal development * Complete and track all application forms and internal checklists and route for appropriate review and signatures * Prepare ancillary proposal materials (e.g., facilities, biographical sketches, budget templates, other support), in coordination with Grants Administrators * Upload all application components for each grant submission to sponsor systems ensuring that the proposal is formatted in accordance with granting agency requirements; Independently problem-solve system errors and escalate to managers as needed Post-Award Responsibilities * Owns initial and annual sub awardee screening process prior to issuing new awards and renewals * Process subrecipient monitoring forms, interacting with subrecipient institutions to collect data, and preparing summaries of findings for management * Own subrecipient reporting in SAM.gov * Monitor Key Personnel effort commitments and work with investigators and Research Funding staff to ensure commitments align with sponsor regulations * Maintain updated Other Support documents for all Key Personnel at the Institute with active awards * Set up post-award files to ensure a complete record is transitioned from the pre-award process * Calendar all reporting requirements and send reminders to internal and external stakeholders * Prepare non-technical components of grant and contract progress reports * Ensure that budgeting, policies, procedures, and agency requirements are met * Manage the award close-out process. Including: collecting materials from internal and external stakeholders, obtaining invention reports from the Legal team, and uploading documents to sponsor system * Schedule and maintain all grant status meetings and track deliverables * Identify issues and escalate to grants administrators, investigators, and the Associate Director, Office of Sponsored Research, as appropriate * Other duties as assigned Required Education and Experience * Bachelors degree or equivalent combination of degree and experience * Intermediate experience with Microsoft Office, including experience managing SharePoint sites * Intermediate experience with Smartsheet Preferred Education and Experience * A minimum of 3+ years grant experience; NIH preferred * Familiarity with Uniform Guidance as it applies to not-for profit institutions * Must have excellent organizational and time management skills with an aptitude to prioritize tasks to meet conflicting deadlines; works well under pressure and reprioritizes workload with conflicting deadlines while maintaining a pleasant composure * Results-oriented work products executed with a high degree of precision and accuracy producing final work products * Strong attention to detail * Ability to communicate effectively internally and externally, both orally and in writing * Ability to work independently and within teams * Ability to problem solve in a collaborative manner * Possess excellent interpersonal skills and ability to remain calm under pressure * Proactive attention to expanding relevant knowledge base * Intermediate experience with Microsoft Office, including experience managing SharePoint sites * Intermediate experience with Smartsheet Physical Demands * Fine motor movements in fingers/hands to operate computers and other office equipment * Standing and sitting for extended periods of time Position Type/Expected Hours of Work * This is a full-time position * This role is currently able to work both remotely and onsite in a hybrid work environment. We are a Washington State employer, and the primary work location for all Allen Institute employees is 615 Westlake Ave N.; any remote work must be performed in Washington State. Annualized Salary Range * $71,100 - $87,100* * Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable. Benefits Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link:

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. Join the Seattle Hub for Synthetic Biology (SeaHub), a new initiative at the intersection of academic creativity and start-up style execution. Our mission is to reimagine living cells and genomes as devices for recording biology and diagnostic information over time, as well as for encoding real-time therapeutic decision-making. Take off with us as we imagine and create a kind of cellular flight recorder that can also seize the controls. Be part of a small dynamic team on the ground floor of a new program with world-class scientists. SeaHub is looking for a lab aide to join our growing lab team. The laboratory aide is an entry-level position responsible for executing repetitive laboratory tasks and lab operations tasks in a quickly changing, methods-diverse laboratory environment. These tasks will likely follow strict Standard Operating Procedures. Good judgment is required for recognizing and reporting process deviations. Excellent attention to detail and the ability to work efficiently in a repetitive task environment are mandatory. This position includes the opportunity to gain experience in a laboratory research environment, and grow into execution of more advanced laboratory tasks, methods, and operations responsibilities over time. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Follow SOPs and good laboratory practices * Maintain lab hygiene, equipment maintenance, and organization * Perform routine molecular biology and tissue culture tasks (as needed and after training) * Executive repetitive lab assays, after training * Receive shipments and stocking reagents * Communicate clearly and accurately with supervisor * Maintain high quality standard of work * Complete routine tasks with minimal supervision * Manage time appropriately Duties and Responsibilities Materials & Inventory Management (Quartzy & Benchling): Ensures accurate tracking, organization, and availability of materials needed for day-to-day operations. * Receive, verify, and document incoming materials and supplies * Maintain accurate digital records and inventory databases * Register samples or materials in tracking systems to support traceability * Conduct regular inventory checks and coordinate timely replenishment Workspace & Operational Support: Helps maintain a clean, organized, and efficient environment to support smooth workflow across the team. * Support general workspace organization and routine upkeep * Restock shared supplies and ensure key consumables remain accessible * Assist with routine operational tasks that contribute to overall workflow efficiency Procurement Assistance: Supports purchasing activities to ensure necessary equipment and supplies are obtained efficiently. * Gather product information, quotes, and vendor details * Prepare and submit purchase or order requests * Assist in tracking orders and coordinating deliveries as needed Safety & Compliance: Contributes to a safe and compliant work environment through proper handling and documentation practices. * Assist with routine safety checks, audits, and compliance activities * Support proper handling and disposal of waste materials according to guidelines * Help maintain documentation related to safety protocols and compliance requirements Documentation & General Support: Maintains accurate internal documentation and provides broad operational support across projects and teams. * Update and maintain internal procedures, guidelines, and handbooks * Prepare basic materials or solutions required for routine workflows * Provide general operational or administrative support for ongoing and ad-hoc projects Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned. Required Education and Experience * High school diploma or equivalent Preferred Education and Experience * B.S. in Cell Biology, Genetics, Synthetic Biology, Bioengineering, Genomics, Molecular Biology, or related field * 0 1 year of related experience * Competence, ability, and enthusiasm to work in a molecular biology and cell culture genomics laboratory * Track-record of being an effective team member with attention to detail * Strong organizational and meticulous record keeping skills * Self-motivated with the ability to take initiative * Exact attention to procedural details * Familiarity with LIMS systems and Microsoft Suite (Excel, Word, etc.) Work Environment * Frequently required to sit, stand, walk, stoop, kneel, reach, or climb ladders * Laboratory atmosphere - possible exposure to chemical, biological or other hazardous substances * Occasional lifting up to 30 pounds * Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with lab equipment Position Type/Expected Hours of Work * This role is currently working onsite and is expected to work onsite for the majority of the working hours. We are a Washington State employer, and the primary work location for Allen Institute's SeaHub employees is 700 Dexter Ave N.; any remote work must be performed in Washington State. Annualized Salary Range * $43,850 - $55,120 * * Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable. Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

AI Research Scientist III - Office of the CTO The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. The mission of the Office of the Chief Technology Officer (CTO) is not only to provide state of the art engineering infrastructure to the Allen Institute as a whole, but to also address high-risk, high-reward questions in biology through AI. We are seeking an independent and motivated Scientist in the Office of the CTO to build large AI/ML models for Biology. Reporting to the Senior Director of AI Applications, you will help develop and apply SOTA AI/ML methods for the representation, analysis and interpretation of multimodal data to understand biological systems in health and disease. This role works collaboratively across all Allen Institute teams including Brain Science, Cell Science, Immunology, Neural Dynamics, and the Seattle Hub for Synthetic Biology (SeaHub). AI/ML focus areas could include multimodal foundation models, diffusion models, causal representation learning, and beyond. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Develop and deploy large scale ML models that deepen our understanding of complex biological systems in health and disease by incorporating diverse biological datatypes, such as multi-omics data, microscopy data, in vivo and behavioral imaging data, electrophysiological data, and/or clinical data. Using ML methods to tokenize and embed biological data for ML models and subsequently analyze ML embeddings for benchmarking and other biological tasks * Help to establish community standards for scalability in developing, disseminating, and evaluating AI/ML/computational methods for scientific problems across the model lifecycle by testing and documenting best practices and sharing with the community * Collaborate with teams of scientists, computational biologists, and software engineers within the Allen Institute and external partners to help drive large scale AI/ML models, from best code practices to scientific impact * Collaborate with software engineers to build state-of-the-art engineering infrastructure at the Allen Institute to support large scale AI/ML research and applications, such as methods for caching and processing petabyte scale data across multiple networked GPU nodes on cloud, this person will build a research grade large scale ML infrastructure that will be hardened by SWE * Participate in institute-wide initiatives, workshops, and seminars to promote cross-disciplinary collaboration and knowledge sharing * Support the promotion of open science through publishing papers and open-source code Note: Reasonable accomodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned. Required Education and Experience * PhD in Computer Science, Applied Mathematics, Computational Biology, Statistics, Biostatistics or similar field; or equivalent combination of degree and experience * Minimum of 5 years postdoctoral / work experience * Demonstrated ability to design, implement and apply AI/ML models for the analysis of large-scale biological data Preferred Education and Experience * 3 - 7 years of experience developing and applying ML methods * Strong publication record of innovative scientific accomplishments (both individual and team) * Expertise in Python-based ML libraries and frameworks such as PyTorch, Jax, Pyro, NumPy, and Pandas. Solid understanding of statistical analysis, data preprocessing, feature selection, and model evaluation techniques * Experience building data pipelines to make biological data ML-ready, pipeline for model training and evaluation. Knowledge of data preprocessing, normalization, and integration techniques specific to biological and clinical datasets * Experience with data visualization and presentation of complex biological findings to both technical and non-technical audiences * Strong problem-solving skills and ability to develop innovative computational approaches to address complex biological questions Physical Demands * Fine motor movements in fingers/hands to operate computers and other office equipment Position Type/Expected Hours of Work * This role is currently able to work both remotely and onsite in a hybrid work environment. We are a Washington State employer, and the primary work location for all Allen Institute employees is 615 Westlake Ave N.; any remote work must be performed in Washington State. Travel * Attendance and participation in national and international conferences Additional Comments * Please note, this opportunity offers relocation assistance * Please note, this opportunity offers work visa sponsorship Annualized Salary Range $183,050 - $240,200* * Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable. Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. The mission of the Allen Institute administration team is to provide support and structure to the scientific divisions. Coinciding with the team science approach, administration helps facilitate team learning and the overall mission of the institute. The Allen Institute Finance team is excited to welcome an analytical, customer-focused Manager of Financial Planning & Analysis (FP&A) to help reshape the planning and modeling capability of the Institute. In this pivotal role, youll partner directly with the Executive Director of Finance and work hands-on across financial modeling, budgeting, forecasting, and process innovation. In addition, this role will manage one direct report, providing leadership and guidance to support team and institute objectives to advance human health. The ideal candidate for this role will be equally comfortable leading a team and rolling up their sleeves to perform in-depth analyses, financial modeling, and building new reporting tools. This position also provides for the opportunity to work with all levels of staff including all teams within Finance, our colleagues in each of our science units, CFO and other executives. In all activities, the Financial Planning team works to increase overall finance efficiency, productivity, and drive business results for the broader Allen Institute. Ideal candidates are solution-oriented and proactive problem solvers. If youre passionate about making an impact, building strong relationships, and driving results in a forward-thinking environment, we invite you to join us and help accelerate transformative science. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Financial Modeling & Analysis * Develop, enhance, and maintain the Institutes long range financial and operational models to support dynamic planning and scenario analysis. * Create what-if scenarios to evaluate financial and operational pressures on the institute and work to mitigate challenges with the team. * Establish best practice for model design, documentation, and version control. * Budgeting & Forecasting * Lead and participate in the preparation for the annual budgeting process from budget targets through approval, including validation and alignment with Institute objectives * Collaborate with program and department leaders to develop budgets and resource plans in line with annual budget targets * Consolidate and validate all budget submissions and prepare executive review and board presentations * Manage quarterly forecast cycles using actuals and adjusted assumptions * Track and report on budget vs. actual performance through automated reporting and provide variance explanations * Design creative solutions to enhance understanding of Institute plans and actuals * Highly organized with utmost standards of accuracy and precision * Process Improvement & Automation * Identify inefficiencies in the FP&A processes and workstreams in order to establish opportunities to streamline * Develop and deploy standard templates, processes, and operating principals within the FP&A team * Implement automated reporting solutions, reducing manual effort and improving accuracy * Develop Power BI reports for self-service analytics for leaders at all levels, synthesizing large datasets into actionable insights * Systems & Data Management * Serve as subject matter expert for Workday Adaptive Planning and Power BI * Incorporate system enhancements and quarterly releases into practice * Collaborate with IT and outside peers to ensure maximizing benefits of systems and tools. * Business Partnering * Provide leadership and mentoring to direct report, fostering professional growth and ensuring alignment with team and institute objectives. * Build stronger partnerships with program, department leaders, and other finance teams to understand business drivers and translate into financial projections. * Take initiative to learn the business of programs and departments, expressing curiosity with a focus on building trust, providing insightful guidance, and developing more efficient processes across teams and within systems. Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned. Required Education and Experience * Bachelor's degree in finance, accounting, economics or related field required * 5+ years of progressive FP&A experience with strong emphasis on financial modeling, budgeting, forecasting, and data analysis. * Prior experience managing a team and or mentoring staff * Demonstrated ability to independently build complex financial models using Excel * Experience with a Financial Planning system (Adaptive, Anaplan, etc.) * Strong understanding of accounting principles and financial statements Preferred Education and Experience * Advanced data visualization and data architecture skills in Power BI, Tableau, etc. * Experience working with large data sets, relational databases, and data query tools (Power Query, SQL, etc.) * Working knowledge of Power Platform tools (Power Automate, Power Apps, etc) * Excellent written and verbal communication skills, including demonstrated ability to present to executive leaders. Physical Demands * Fine motor movements in fingers/hands to operate computers and other office equipment Position Type/Expected Hours of Work * This role is currently able to work both remotely and onsite in a hybrid work environment. We are a Washington State employer, and the primary work location for all Allen Institute employees is 615 Westlake Ave N.; any remote work must be performed in Washington State. Annualized Salary Range * $119,650 - $164,505* * Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable. Additional Comments * Please note, this opportunity does not sponsor work visas and has no relocation assistance Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outline in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

Director, Environment Health & Safety, Scientific Support Services Administrative Division * To be considered for this role, please submit a cover letter along with your application The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. The mission of the Allen Institute administration team is to provide support and structure to the scientific divisions. Coinciding with the team science approach, Administration helps facilitate team learning and the overall mission of the institute. This director-level position leads the Environment Health & Safety (EHS) team within the Scientific Support Services (S3) department. This position will work with the Sr. Director, Scientific Support, to provide strategic planning, systems, operational goals and timelines, policies, guidelines, and training to support environmental compliance and occupational safety, and to keep pace with our scientific research goals. The Scientific Support Services department provides services and support critical to our Team Science, Big Science, and Open Science approach by providing a foundation of safety, quality, service, and compliance. The ideal candidate will work collaboratively with research teams from each scientific unit to proactively understand their safety compliance needs and will translate these to develop and implement effective safety policies and guidelines to ensure a safe workplace for research. This is an opportunity to lead change by proactively growing the EHS team, systems, guidance, and services in support of the Allen Institutes mission and growth. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Direct strategic planning and operational implementation for the EHS team responsible for employee safety training, occupational health, chemical hygiene, lab safety, emergency response, employee exposure assessment, radiation and laser safety, biosafety, required regulatory reporting, workers compensation claims, accident prevention and investigation, hazardous material disposal and inventory, ergonomics, Safety Committee, Laser Safety Committee, and more * Assess and verify compliance with environmental and occupational safety regulations for the use of chemicals, biological agents, research animals, radioactive materials, class IV lasers, etc. * Verify laboratories and associated operations meet the Institute's safety standards and policies * Lead the Allen Institute EHS team, including on-call responsibilities * Lead and direct the team to develop, prioritize, and plan for annual goal setting, and determine timelines, budgets, and resources to support successful execution * Recruit, build, mentor, train, develop, and support growth for EHS staff * Support and sometimes develop initiatives related to diversity, equity, inclusion, and belonging in alignment with Allen Institute core principles * Partner with scientific research teams to enhance and implement a durable service environment that can accommodate growth efficiently * Work with research teams to understand their use of hazardous materials; identify risk and propose risk management approaches, assist in implementing best practices, safe handling requirements, proper storage, and compliant disposal focused on protecting the environment * Manage quality assurance for written programs, processes, training content, chemical inventory, and web-based content * Manage records retention and timely disposal as determined in policy, including personal occupational health information, exposure records, and chemical inventories * Responsible for strategic planning and decisions for the EHS team that are in line with Institute goals and objectives * Collaborate with the EHS and Scientific Support Services teams to plan the scope and schedule of significant projects such as software implementation, safety audits, training development or improvement, contracted services, guidelines, or program development * Manage and maintain vendor relationships and service delivery expectations * Provide leadership and subject expert support for the Allen Institute Safety Committee, Institutional Biosafety Committee, Laser Safety Committee and Institutional Animal Care and Use Committee * Develop strategy to scale services to meet organizational objectives, growth, and budgets * Develop and implement safety inspection process for laboratory and non-laboratory spaces * Support emergency response and disaster recovery planning and development effort Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned. Required Education and Experience * Master of Science in industrial hygiene, toxicology, environmental health, public health, or equivalent combination of degree and experience * 12+ years of experience working in research or in similar risk management roles overseeing regulatory compliance, occupational safety and health, biological safety, or an equivalent combination of degree and experience * 5+ years of experience in a leadership position managing staff * Professional certification in one or more of the following: industrial hygiene, biosafety, safety, or hazardous materials management Preferred Education and Experience * Detail-focused and organized with an understanding that communication and transparency are critical to achieving success * Excellent verbal and written communication skills * Intermediate to advanced skills with MS Office, including Word, Excel, PowerPoint, Outlook, Smartsheet and SharePoint * A team player and natural leader with strong interpersonal and collaboration skills; ability to navigate challenging group dynamics, work effectively across scientific, technical, and business interfaces * Demonstrated ability to work independently, proactively, and with agility in a complex, matrixed environment, dealing well with ambiguity at times, building internal alignment, influencing others, and managing differences effectively * Ability to recognize and quickly identify and resolve conflict * Experience with ServiceNow or similar workflow management software * Experience managing or providing on-call services Work Environment * Will enter laboratory environment, including potential exposure to lasers, biohazards, chemicals, and research animals * Will be required to wear personal protective equipment Physical Demands * Ability to push and pull up to 50 pounds. May need to lift up to 30 pounds * Fine motor movements in fingers/hands to operate computer, other office equipment, and lab equipment * Repetitive motion and extended periods of sitting Position Type/Expected Hours of Work * This is a critical job and expected to report for work regardless of weather and/or other conditions * Occasional evening and weekend hours may be required * This position is expected to be available for emergency response * This role is currently able to work both remotely and onsite in a hybrid work environment. We are a Washington State employer, and the primary work location for all Allen Institute employees is 615 Westlake Ave N.; any remote work must be performed in Washington State. Travel * Occasional travel to support benchmarking * Attendance and participation in national conferences Additional Comments: * Please note, this opportunity offers relocation assistance * Please note, this opportunity does not offer work visa sponsorship Annualized Salary Range * $195,850 $282,645* * Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable. Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institute's Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

The mission of the Allen Institute is to understand the principles that govern life, and to advance health. Our creative and multi-dimensional teams focus on answering some of the biggest questions in bioscience. We accelerate foundational research, catalyze bold ideas, develop tools and models, and openly share our science to make a broad, transformational impact on the world. The Allen Institute for Neural Dynamics is seeking a Principal System Design Engineer to join the Scientific Instrumentation and Process Engineering (SIPE) team. In this critical role, the principal engineer will lead the design and integration of advanced scientific instruments, developing innovative and robust solutions that meet the complex demands of neuroscience research. Responsibilities include setting technical direction, mentoring senior engineers, and ensuring all design and execution processes meet the highest standards of excellence. Candidates for this role should possess extensive experience in systems engineering, with a proven background in integrating both hardware and software components. The ability to lead multidisciplinary teams is essential, as collaboration is a key aspect of the SIPE teams approach. Mastery of system design principles is required, along with demonstrated leadership in technical innovation. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Spearhead the architecture, design, and integration of complex scientific instruments that combine robotics, imaging, automation, and control systems * Serve as a pillar of technical leadership for SIPE initiatives, providing guidance to senior and mid-level engineers and overseeing collaborative development efforts that span both hardware and software domains * Manage projects from concept through production, including feasibility studies, prototyping, and final rollout, while formulating comprehensive project plans to ensure timely delivery * Collaborate with scientific stakeholders to capture system requirements, translate them into actionable team tasks, and remain engaged throughout prototyping and development * Set and refine standards for engineering processes, including documentation, validation, source code management, issue tracking, deployment procedures, and observability * Design, develop, evaluate, and implement equipment for control operations, data acquisition, and analysis workflows, ensuring reliable collection of large-scale datasets * Leverage broad technical expertise and creativity to resolve complex challenges * Champion organizational strategies that enhance innovation, open science, and operational efficiency Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned. Required Education and Experience * Bachelor's degree in mechanical, electrical, optical, or systems engineering, or related field; or equivalent combination of education and experience * 7 years of progressive experience in system design engineering, including leadership of complex instrumentation projects * Demonstrated success in delivering production-ready systems for scientific or medical instrumentation Preferred Experience and Competencies * Masters degree or PhD in mechanical, electrical, optical, or systems engineering * 15+ years of combined education and experience in multidisciplinary system design * Multidisciplinary expertise: Demonstrated leadership-level or hands-on expertise in three or more of the following technical domains: * Systems Integration: Proven ability to design and integrate complex systems across mechanical, electrical, optical, and software domains * Optical Engineering: Deep knowledge of microscopy techniques (confocal, multiphoton, fluorescence) and application of lenses, mirrors, filters, and opto-mechanical components * Electronics: Design of AC/DC circuits, electrical schematics, and PCB layouts for microcontrollers and embedded systems * Software: Knowledge and familiarity of programming languages such as C/C++, C#, Matlab or Python, the software development lifecycle, and common software development tools, e.g. IDEs, Git, CI/CD * Imaging & Data Acquisition: Integration of imaging systems and analog/digital data acquisition tools into automated workflows * Robotics & Automation: Development of robotic systems for surgical, tissue handling, and precision automation applications * Fluidics: Application of fluidics concepts for gases and Newtonian fluids, including regulators, valves, flow control, gauges, and fittings * AI and Machine Learning: Hands-on experience applying artificial intelligence and machine learning algorithms for image analysis, anomaly detection, and predictive maintenance within automated instrumentation and high-throughput workflows Physical Demands * Occasional lifting up to 30 pounds * Fine motor movements in fingers/hands to operate computers and other office equipment * Push/pull up to 50 lbs * Stooping, bending, crouching * Reaching or climbing ladders Position Type/Expected Hours of Work * This role is currently working onsite and is expected to work onsite for the majority of the working hours. We are a Washington State employer, and the primary work location for Allen Institute employees is 710 9th Ave N.; any remote work must be performed in Washington State Additional Comments * Please note, this opportunity does not provide work visa sponsorship or relocation assistance Annualized Salary Range * $167,850 - $209,750 * * Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

Current HHMI Employees, click here to apply via your Workday account. HHMI is focused on supporting and moving science forward in a variety of different ways ranging from conducting basic biomedical research, empowering educators, inspiring students, developing the next generation of scientists - even stretching into film and media production. Our Headquarters is in the greater Washington, DC metro area and is home to over 300 employees with expertise in investments, communications, digital production, biomedical sciences, and everything in between. The work housed here supports and augments the groundbreaking research conducted in HHMI labs across the nation. As HHMI scientists continue to push boundaries in laboratories and classrooms, you can be sure that your contributions while working here are making a difference. We are always open to finding self-motivated and highly organized Administrative Coordinator candidates for potential opportunities within our labs in the University of Washington area. The best candidates will be passionate about providing top notch administrative support for our Investigators and helping to foster a warm and welcoming lab environment. A keen eye for details and desire to provide excellent customer service are vital for success, and this role is best fit for someone who is a self-starter and proactive in their support style. Applications are accepted on a rolling basis. You will be contacted by a member of our Recruitment team if your skills and experience appear to be a match when a role opens. Principal Responsibilities: Provide administrative support for the HHMI Investigator Manage the calendar and coordinate complex scheduling, including internal and external meetings, conferences, professional engagements, and travel for the Investigator Coordinate domestic and international travel arrangements and prepare detailed travel itineraries Organize weekly laboratory meetings, special seminars, and laboratory outings Assist with correspondence management, presentation development, and be a resource for reviewing and proofreading documents from draft form Work with researchers on visa and academic appointment issues Order office supplies and reconcile monthly purchasing card expenses Assist lab staff with onboarding requirements and HMS appointments Coordinate letters of recommendation Process and track reimbursements from multiple sources for Investigator, laboratory members and visiting scientists through multiple systems Keep laboratory website updated Serve as a liaison between investigator and various administrative offices Handle phone calls, screen and greet visitors Required Skills: B.A./B.S. or equivalent years of education and experience Minimum of 5 years of high-level executive support Prior experience with sophisticated, detailed travel support a strong plus Ability to assess rolling tasks in a fast-paced lab and prioritize accordingly Excellent written, verbal, and interpersonal communication skills and the ability to use good judgment in working independently, showing initiative, and responding to inquiries Ability to work both independently and as part of a team, manage time, and show initiative Customer service approach and dedication to HHMI's mission and the lab's goals Strong digital literacy, including demonstrated proficiency with Mac or PC as well as Microsoft Office applications Physical Requirements Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis. Please Note: This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act. Compensation Range: Administrative Coordinator, Washington - $69,230.00 (minimum) - $86,600.00 (midpoint) - $112,470.00 (maximum) Pay Type: Annual HHMI's salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal consistency when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range. Compensation and Benefits Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more. HHMI is an Equal Opportunity Employer We use E-Verify to confirm the identity and employment eligibility of all new hires.

Senior Manager, Large Format Spatial Biology The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. The Allen Institute is launching a new moonshot initiative on human brain health and disease. This initiative aims to dramatically accelerate our understanding of human brain structure and function, identify the molecular, cellular and circuit basis of disease progression, and pioneer new therapeutic strategies targeting vulnerable and affected cell types. Our mission focuses on taking a human-centric approach to understanding and treating disease, combining a large-scale open science discovery approach across multiple diseases, AI-based disease modeling, and translational programs in specific diseases to move from discovery to clinical application. We aim to make transformational change in understanding and treating brain disorders, the biggest health challenge of our time. Recent advances in spatial molecular analyses of brain tissues with high information content transcriptomic, proteomic and connectomic methods are rapidly transforming how we can understand brain structure and function in health and disease, accelerated by the recent commercialization of spatial platforms. Application to important areas of human neurobiology and neurobiology of disease is now possible, albeit with the need for technical innovation to scale to large format needed to understand brain-wide phenotypes of human brain structure and function. We are seeking an outstanding individual to lead a large format spatial biology core, to collaborate with internal and external partners to bring in new technologies, optimize them for application to human brain tissues, and manage a core facility to deliver high-throughput datasets as part of coordinated large scale projects. This individual should have experience in imaging core management, and is highly motivated to support creation of an imaging core to take on the specific challenges of large-format imaging of large human brain specimens. This role will also foster innovation on new assays and technologies and actively participate in scientific programs to accelerate discovery and translation in brain disorders. The successful candidate will have direct expertise in spatial methods and experience running core facilities. The Senior Manager, Spatial Biology, will be responsible for supervising, directing and at times executing a wide variety of tasks provided by the core that are necessary for advancing our scientific goals focused on understanding the human brain in the healthy and the disease states. The Allen Institute offers exceptional working conditions, and nurtures team science in an intellectually rich and stimulating setting. We provide a highly collaborative research environment offering the opportunity to interface closely with our molecular and cell biologists, bioinformaticians, and partner Institutions. We believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Develop, implement and maintain custom and commercially-available solutions to assess gene expression in large format tissue sections, especially but not limited to human brain * Daily, direct supervision and management of a team responsible for generating high quality spatial transcriptomic data and/or building the processes for data acquisition, quality control and transfer to the cloud * Participate in complex, multi-team collaborative projects on human brain healthy and diseased brain spatial analyses * Manage a high throughput core, including day-to-day operations, staffing, scheduling, budgeting, and financial governance * Seek and evaluate new cutting-edge techniques in related areas * Participate in new technology development efforts * Support and drive multiple projects in parallel, focusing on both exploratory technology development projects as well as large scale data generation for established projects and collaborations with the scientific community * Collaborate across teams within the Allen Institute to ensure accuracy and efficiency in the relevant data generation pipelines, including advising teams on upstream specimen generation, handling and processing, and downstream data analysis * Present at internal scientific meetings and scientific conferences * Contribute to manuscripts and grant applications * Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.* Required Education and Experience * Ph.D. or equivalent in neuroscience or life sciences * Minimum of 8 years of related work experience and/or training * Deep knowledge of spatial transcriptomics and related methods to quantify gene expression in situ * Expertise in large format imaging and microscopy, fluidics and sample handling necessary to scale technology platforms to handle high throughput data generation pipelines * Excellent judgement and problem-solving skills * Strong technical ability to work across multiple software tools to ensure that data is processed and tracked in an accurate and transparent manner Preferred Education and Experience * Ph.D. in neuroscience or life sciences * Knowledge of human and non-human primate neuroanatomy * Familiarity with cell type classification in mammalian brains * Expertise in the MERFISH or similar spatial transcriptomics platforms * Experience in technological and scientific innovation with high information content spatial molecular technologies and methods * Familiarity with and willingness to learn cutting edge spatial proteomics methods and techniques * Willingness to utilize advanced computational approaches (including machine learning and AI) to improve and accelerate work products * Proven track record of scientific publications in peer-reviewed journals related to spatial transcriptomics and associated fields * Excellent written and verbal communication skills * Collaborative, innovative and team-science focused mindset and experience Work Environment * Laboratory environment - possible chemical, biological, or other hazardous substances exposure * This may include wearing personnel protective equipment (PPE) Physical Demands * Fine motor movements for operating computers and lab equipment Position Type/Expected Hours of Work * This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N. Annualized Salary Range $156,850 - $196,050* * Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable. Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

The mission of the Allen Institute is to understand the principles that govern life and to advance health. Our creative and multi-dimensional teams focus on answering some of the biggest questions in bioscience. We accelerate foundational research, catalyze bold ideas, develop tools and models, and openly share our science to make a broad, transformational impact on the world. The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through integration of experiments, modeling, and theory. We are looking for a Research Associate I as part of an interdisciplinary team working on spatial transcriptomics. The goal of our team is to produce high quality in situ hybridization data in order to characterize cell types in the brain. This person is responsible for executing a variety of laboratory tasks and/or experiments in a high-throughput laboratory environment following Standard Operating Procedures (SOPs). Good judgment and problem-solving skills are required for process development, recognizing process deviations, participating in troubleshooting, and operation of complex laboratory instrumentation. The successful candidate is well-organized, with curiosity to answer scientific questions, and takes pride in producing high quality data in a timely manner. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Please include a cover letter with your application describing your career goals and the reasons youre interested in this position. Essential Functions * Operate fluorescence imaging microscopes * Handling of mouse and human tissue * Perform multiple histological staining processes (Nissl, IHC, Biocytin, ISH) * Prepare and assemble custom slides and imaging chambers * Operate MERSCOPE, Xenium and any other imaging equipment within the team * Compile, process and analyze data; evaluate and communicate research results * Evaluate, calibrate, and troubleshoot experiment quality and instrument functionality * Contribute to a rigorously scientific, cohesive and efficient team environment * Maintain accurate laboratory documentation using established methods, which may include Microsoft Office, Custom Laboratory Information Management System (LIMS), and other packages * Follow Standard Operating Procedures, good laboratory practices, and comply with all regulatory requirements * Other duties as assigned * Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.* Required Education and Experience * Bachelors degree in a life science or related field * Basic knowledge of neuroscience and cell biology Preferred Education and Experience * Exceptional manual dexterity and attention to detail * Strong scientific communication skills (written and oral) * 0-2 years experience working in a laboratory setting * Laboratory experience with cell or molecular biology * Hands-on experience working with microscopes * Strong computer skills, knowledge of databases, and reading/running scripts * Understanding of custom imaging software programs Work Environment * Laboratory environment, including potential exposure to lasers, biohazards * Occasional exposure to safety hazards, noises, change in temperature, chemicals, and other hazardous materials and machinery * Exposure to Class IV lasers Physical Demands * Stooping, bending, crouching * Reaching, or climbing ladders * Must be able to resolve red/green colors * Fine motor movements in fingers/hands to operate computers and other office equipment, lab equipment Position Type/Expected Hours of Work * This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N. * Occasional weekend hours may be required Additional Comments * Please note, this opportunity does not sponsor work visas * Please note, this opportunity may offer relocation assistance Annualized Salary Range * $54,250 - $66,450* * Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable. Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outline in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide: ******************************************** It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.

Investigator Huntingtons Disease Biology and Therapeutics The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. The Allen Institute is launching a new moonshot initiative on human brain health and disease. This initiative aims to dramatically accelerate our understanding of human brain structure and function, identify the molecular, cellular and circuit basis of disease progression, and pioneer new therapeutic strategies targeting vulnerable and affected cell types. Our mission focuses on taking a human-centric approach to understanding and treating disease, combining a large-scale open science discovery approach across multiple diseases, AI-based disease modeling, and translational programs in specific diseases to move from discovery to clinical application. We aim to make transformational change in understanding and treating brain disorders, the biggest health challenge of our time. We are seeking an outstanding individual to lead a new translational program in Huntingtons Disease (HD) focused on genetic therapies targeting disease-affected cell types and molecular programs. The successful candidate will be an established, internationally recognized researcher in Huntingtons disease with a strong track record of research and publication in understanding HD disease mechanisms and in preclinical studies using genetic strategies to attenuate disease progression. This candidate should be a thought leader in the field, have deep relationships with relevant HD foundations, funders and industry players in HD therapeutics, and a strong track record of obtaining funding for HD research. They should be highly motivated and driven to move from findings gleaned from studies of disease characterization to identification of actionable targets, preclinical target advancement and first in human trials. The ideal candidate is a self-motivated team player who is willing to push the boundaries of human neuroscience and disease research through scientific leadership, individual and team contributions and continuing scholarship on the ever-changing landscape. The successful candidate will also have excellent communication skills that can represent our efforts to our stakeholders internally and in external forums. The Allen Institute offers exceptional working conditions, and nurtures team science in an intellectually rich and stimulating setting. We provide a highly collaborative research environment offering the opportunity to interface closely with our molecular and cell biologists, bioinformaticians, and partner Institutions. This is a Principal Investigator position comparable to a Full Professor in a University/Medical School setting. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Lead breakthrough research and deployment of state-of-the-art disease-modifying approaches to treating Huntingtons disease * Contribute to forming and participating in a larger precision medicine program based on cell-and circuit-targeting therapeutics across multiple diseases * Advise and mentor a group of scientists and technicians performing molecular, behavioral and other relevant techniques in HD models, ideally combining with selective cellular targeting tools developed at the Allen Institute * Assist and participate in enabling and optimizing discovery science efforts to characterize human HD progression and mechanisms * Seek and evaluate new cutting-edge techniques in related areas, such as gene regulatory approaches applicable to gene therapy applications * Work synergistically with bioinformaticians and data scientists * Publish and present findings in peer-reviewed journals and scientific meetings * Serve in relevant advisory roles in the HD community * Present a periodic summary of progress to the research community, Institute executive leadership and external advisors * Pursue external funding through grant writing and submission to federal and private foundation funding agencies * Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.* Required Education and Experience * Ph.D. and/or M.D./Ph.D. in experimental neuroscience or biology, physics, engineering, or related academic or biomedical discipline * Minimum of eight years relevant experience in experimental and/or computational neuroscience, with supporting publication record * Domain knowledge of systems, cellular and/or molecular neuroscience, with emphasis on Huntingtons disease * Proven experience working independently as well as in a collaborative high paced environment * Demonstrated experience working with outside collaborators to achieve defined objectives Preferred Education and Experience * 10 or more years of post-PhD working experience in Huntingtons disease biology * 10 or more years of experience teaching scientific courses or workshops in formal settings * Proven track record in procuring funding in the form of grants, awards, and/or contracts * Proven track record of success publishing in high impact journals * Excellent management skills and ability to work in a group and interact closely with scientific and technological collaborators * Proven strong written and verbal communication skills Work Environment * Laboratory environment may require entering labs where experiments take place * Exposure to and handling of laboratory animals may be required * This may include wearing personnel protective equipment (PPE) * Working at a desk with computer analyzing data Physical Demands * Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with lab equipment. Position Type/Expected Hours of Work * This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N., with the flexibility to work remotely on a limited basis. Travel * Occasional travel to collaborator sites * Occasional attendance and participation in national and international conferences may be required Additional Eligibility Qualifications * All employees who work with live animals must complete an Occupational Health medical history form and/or consultation with an Occupational Health Provider and receive clearance to work with animals. Depending on your health history and job responsibilities, an annual respiratory health screening and clearance to use a respirator may also be required. Additional Comments * Please note, this opportunity offers relocation assistance * Please note, this opportunity may offer work visa sponsorship Annualized Salary Range $224,200 - $294,250* * Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable. Benefits Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. The mission of the Allen Institute administration team is to provide support and structure to the scientific divisions. Coinciding with the team science approach, administration helps facilitate team learning and the overall mission of the institute. Were growing our People & Culture (P&C) team to track with the expanding reach of our scientific focus as we launch new Institutes and scientific departments. Operating like a high-performance startup within a well-established and funded non-profit, our team is scaling services, practice and delivery with the aim of unlocking overall resourcing capacity and collective velocity toward our Mission. In this role, you will partner with Scientific Business Unit leadership, P&C colleagues and Administration teams to support our evolving organizational and people engagement needs. This role is both strategic and hands-on, providing full-cycle human resources consultation, delivering people initiatives, coaching employees and managers through the employment lifecycle and optimizing P&C programs. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Successfully establish and maintain professional, trusted relationships, strong customer focus and work effectively with leaders, managers and employees * Be a champion of the Allen Institute Mission and contribute to our Values-based culture by coaching leadership teams to improve engagement and effectiveness * Apply qualitative and quantitative data and a partnering approach with P&C colleagues and senior leadership to recommend, develop and implement solutions to address talent priorities, , employee engagement and development, performance management and recognition, organizational design and impact, succession planning, and program optimization * Coach managers on effective leadership strategies including tactical P&C processes as well as interventions involving leadership development and change management * Serve as a skilled facilitator of critical conversations, able to lead investigations, mediate when needed and provide practical advice * Apply expertise in Allen Institute guidelines, policies and procedures, tools and resources; Advise managers and employees on complex issues providing solid guidance on legal and regulatory trends * Serve in both lead and support roles as needed, ensuring projects are effectively prioritized, scoped and successfully delivered * Be a strong contributor and mentor within the overall People & Culture team, ensuring handoffs and processes are continuously improved across all scientific research institutes and administrative teams * Process Improvement: Proactively looking for ways to enhance our overall employee experience and improve our current processes Required Education and Experience * Bachelors Degree plus 7+ years in progressively responsible People & Culture (Human Resources) roles, having Generalist experience; or equivalent combination of degree and experience * Knowledge of human resources laws and processes * Human Resources information system (HRIS) experience Preferred Education and Experience * Hands-on immigration experience working with employees on Visas and collaborating with outside legal counsel * Excellent verbal and written communication skills * Ability to navigate sensitive or ambiguous situations with a high level of diplomacy and discretion * Demonstrated ability identifying root causes of complex issues to design and implement practical solutions, both independently and within a collaborative team setting * Mindset of continuous learning and improvement to support customer needs * Demonstrated experience delivering P&C programs and related process improvements * Reputation for delivering high touch employee and manager experience Physical Demands * Occasional lifting up to 20 pounds * Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with lab equipment. * Stooping, bending, crouching Position Type/Expected Hours of Work * May require occasional evening and weekend hours * This role is currently able to work both remotely and onsite in a hybrid work environment. We are a Washington State employer, and the primary work location for all Allen Institute employees is 615 Westlake Ave N.; any remote work must be performed in Washington State. Travel * Occasional local travel to Dexter Yard or other Allen Institute locations * Attendance and participation in national and international conferences required [ note that travel may not be required to attend] Annualized Salary Range * $128,050 - $176,055* * Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable. Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outline in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

Scientist I Analysis of Alzheimers Disease Multiomics Data Human Cell Types The mission of the Allen Institute is to understand the principles that govern life, and to advance health. Our creative and multi-dimensional teams focus on answering some of the biggest questions in bioscience. We accelerate foundational research, catalyze bold ideas, develop tools and models, and openly share our science to make a broad, transformational impact on the world. The Seattle Alzheimers Disease Brain Cell Atlas (SEA-AD) consortium strives to achieve a deep molecular and cellular understanding of the early pathogenesis of Alzheimers disease (AD). Leveraging advances in quantitative neuropathology and next-generation single cell molecular profiling technologies we are generating large-scale data sets from well-characterized donors that span the spectrum of AD pathology to comprehensively map human brain cell types across aging and disease. These data along with tools for their use are made freely and publicly available. We seek to hire a Scientist to analyze and interpret these datasets, which will include heterogeneous donors spanning the variability seen in AD. The position will explore changes to cell types common across co-morbidities, sexes, races, and more using quantitative measures of neuropathology and whole genome sequencing generated data from each donor. This position will leverage existing computational tools and develop novel pipelines and approaches to analyze and interpret these data. This position will collaborate with a dynamic team of quantitative and experimental scientists to build a quantitative framework for how and how consistently cell types are impacted in AD, with a goal of identifying common signatures of early Alzheimers disease. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Adapt existing or develop novel computational tools to rigorously quantify changes in cell types in Alzheimers disease across community datasets * Associate gene expression and chromatin accessibility changes with relevant and available donor metadata or secondary data types (e.g. structural imaging or blood biomarkers) * Compare cell type changes across disease progression across axes of heterogeneity to identify common early changes that may inform biomarkers * Interact with scientists from diverse backgrounds and perspectives to design analytical approaches and refine computational strategies * Work with experimental scientists to design experiments to validate predictions of disease function * Participate in a highly interactive and multidisciplinary environment * Publish and present findings in peer-reviewed journals and scientific conferences Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned. Required Education and Experience * Ph.D. in Neuroscience, Computational Neuroscience, Computer Science, Applied Math, or related field; or equivalent combination of degree and experience * Fluency programming in Python in high performance computing * Fluency with version control systems (e.g. Git/Github) * Familiarity with analysis of RNA-sequencing or related data types Preferred Education and Experience * Experience with modeling disease or developmental trajectories, or related computational studies * Additional experience in computational analysis and statistical assessment of biological datasets in other modalities such as spatial statistics, ATAC-seq analysis, computational anatomy, or related fields * Previous work on studying Alzheimers disease or other neurodegenerative diseases * Familiarity with additional programming languages (e.g., R) * Experience with GPU-based deep learning * Ability to work effectively in a highly collaborative environment * Strong written and verbal communication skills * Ability to work independently and collaboratively * Strong publication track record Physical Demands * Occasional lifting up to 30 pounds (reference: a ream of paper weighs approx. 5lbs * Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with lab equipment Position Type/Expected Hours of Work * This role is currently able to work both remotely and onsite in a hybrid work environment. We are a Washington State employer, and the primary work location for all Allen Institute employees is 615 Westlake Ave N.; any remote work must be performed in Washington State. Travel * Occasional attendance and participation in national and international conferences Additional Comments * Please attach a cover letter with your application * Please note, this opportunity offers relocation assistance * Please note, this opportunity may offer visa sponsorship Annualized Salary Range $92,250 - $114,100 * * Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable. Benefits Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide:

Current HHMI Employees, click here to apply via your Workday account. HHMI is focused on supporting and moving science forward in a variety of different ways ranging from conducting basic biomedical research, empowering educators, inspiring students, developing the next generation of scientists - even stretching into film and media production. Our Headquarters is in the greater Washington, DC metro area and is home to over 300 employees with expertise in investments, communications, digital production, biomedical sciences, and everything in between. The work housed here supports and augments the groundbreaking research conducted in HHMI labs across the nation. As HHMI scientists continue to push boundaries in laboratories and classrooms, you can be sure that your contributions while working here are making a difference. We are always open to finding self-motivated and highly organized Laboratory Manager candidates for potential opportunities within our labs in the University of Washington, area. Applications are accepted on a rolling basis. You will be contacted by a member of our Recruitment team if your skills and experience appear to be a match when a role opens. The Lab Manager role is responsible for supervising and performing technical and administrative tasks on a day-to-day basis in support of the lab's research and operational needs. This role oversees equipment maintenance, ensures adequate supplies for experimental needs, assists the Investigator in personnel management, manages lab safety programs to ensure compliance with all applicable regulations, assists in laboratory space and facilities planning, makes recommendations for changes, maintains inventory of laboratory furniture and equipment, and serves as the liaison to both HHMI and host institution administrative offices. Essential Duties and Responsibilities: Manage day-to-day activities within the research laboratory, including such activities as ensuring operation of essential equipment, making sure adequate supplies are available for routine experimental procedures, reviewing budgets, etc. Act as liaison between lab and HHMI and host institution administrative offices on issues such as budget management, fixed asset inventories, purchasing, use of host accounts, etc. Act as liaison between lab and host safety and regulatory offices to ensure compliance with all applicable regulations. Develop laboratory guidelines; maintain procedures manuals; and/or evaluate new materials and equipment. Train incoming personnel in proper lab conduct. May train others in technical areas and complex processes. May carry out research project. May evaluate new techniques and technology. May plan for and provide working supervision to the work of Research Technicians or other junior laboratory personnel. Qualifications: Education: Bachelor's degree in health or physical sciences; or an equivalent combination of education and related work experience. Advanced degree is a plus. Experience: Three or more years of laboratory experience including at least one year of supervisory experience. Skills and Abilities: Operational knowledge of advanced lab equipment. Ability to supervise others. Ability to initiate and compose communications for various purposes in an appropriate style. In-depth understanding of organizational structure both within and outside the work unit, including the role of each position in the group and in other groups. Ability to develop instructional material for routine training purposes. Ability to review goals, analyze processes necessary to achieve those goals, and develop techniques and systems required to meet those goals. Often explores new areas and seeks opportunities to apply new knowledge to work. Physical Requirements: Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances. Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis. Please Note: This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act. Compensation Range: Laboratory Manager I, Washington - $81,880.00 (minimum) - $102,400.00 (midpoint) - $133,055.00 (maximum) Pay Type: Annual HHMI's salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal consistency when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range. #LI-NG1 Compensation and Benefits Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more. HHMI is an Equal Opportunity Employer We use E-Verify to confirm the identity and employment eligibility of all new hires.

Primary Work Address: Health Science Building, Seattle, WA, 98195-7370Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the discovery and sharing of scientific knowledge to benefit us all. As a biomedical research organization and philanthropy, HHMI supports a vibrant community of academic researchers, educators, students, and professionals. Together, we're unlocking the fundamentals of biology and building an open, inclusive future for science. We have an outstanding opportunity for a Postdoctoral Scientist to join the lab team of Dr. Alison Feder, Freeman Hrabowski Scholar, based in the Department of Genome Sciences at the University of Washington in Seattle. The Feder lab investigates the dynamics of rapidly evolving populations, especially viruses and bacteria evolving within their hosts and solid tumors progressing to malignancy. In particular, they are characterizing how spatial organization shapes these evolutionary outcomes and developing approaches to leverage spatial data to better understand evolutionary histories. More information about the lab and their work can be found by visiting *************************** About the Postdoctoral Scientist role: This role is an ideal fit for an intellectually curious, creative, and driven scientist ready to gain further professional training while bringing passion for discovery and enthusiasm for contributing to the Feder lab's goals. The ideal candidate thrives on collaboration, demonstrates strong communication skills, and is committed to professional growth and development. What we provide: A competitive compensation package with comprehensive health and wellness benefits. Full access to HHMI's on-demand online training courses and skill-building seminars. Generous and stable research funding from HHMI. Joining the vibrant UW research community. Mentorship from a leader with a growth mindset who values scientific curiosity and cross-disciplinary thinking Opportunities to develop an independent research portfolio and mentor junior scientists What you'll do: Based on your career interests, you will have the opportunity to either develop your own research project in the lab or work on an established research project involving rapid evolutionary dynamics in viruses, bacteria and cancer contexts Write scientific manuscripts describing research findings. Attend local and national meetings to present research findings, learn about the latest advances in the field, and develop a scientific network. What you bring: A PhD in the life sciences, computer science or applied mathematics is required. Focus on genetics, genomics, evolutionary biology, or computational biology is preferred. Experience with Python, R or a different scripting language is required. Experience with mathematical modeling and/or the analysis of next generation sequencing data would be a plus. A self-motivated mindset with the persistence to explore innovative research and address challenging scientific problems. Strong problem-solving skills, with the ability to tackle challenges creatively. Excellent communication skills with the ability to present and discuss findings clearly in diverse settings. A flexible and adaptive approach, willing to learn new techniques, share expertise, and contribute to the collective success of the team. Excellent organizational and time management skills. Meticulous approach to work with a high level of attention to detail. Ability to work successfully within a collaborative and congenial environment. Strong commitment to research integrity. Physical Requirements Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis. Please Note: This job description sets forth the job's principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act. #LI-NG1 Compensation and Benefits Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more. Compensation Range $70,000.00 (minimum) - $80,500.00 (midpoint) - $91,000.00 (maximum) Pay Type: Annual HHMI's salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal consistency when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range. HHMI is an Equal Opportunity Employer We use E-Verify to confirm the identity and employment eligibility of all new hires.

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science. Join our artificial intelligence powered lab, an initiative at the intersection of academic creativity and start-up style execution. Our mission is to apply machine learning to biological design. Join us as we build a series of interconnected design-test-loop flywheels that enable design of synthetic enhancers, protein binders, and more. We are looking for a Senior Research Associate to join our synthetic enhancer flywheel. The Associate will be working in the laboratory to clone and screen Massively Parallel Reporter Assay (MPRA) libraries in a variety of biological models from cell lines to multicellular in vivo models to mouse in vivo. They will optimize library delivery, process RNA and DNA through generation of Illumina sequencing data for model training, and then evaluate model success by testing designed sequences using dd PCR, flow cytometry, and other molecular biology assays as a readout. They will be on the cutting edge of the field of high throughput screening, optimizing workflows in new multicellular models as the active learning needs for the AI model evolve. At the Allen Institute, we believe that science is for everyone and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly. We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment. We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions. Essential Functions * Develop advanced high throughput screen capabilities in multicellular models, preferably with single cell readout (e.g. mouse in vivo, gastruloids, embryoid bodies, teratomas) * Design validation experiments to benchmark performance of synthetic enhancer design AI models * Maintain and propagate human cell lines, optimize and perform plasmid DNA transfections and viral transductions * Perform advanced genomics protocols (e.g., custom amplicon sequencing, RNA-seq, single cell RNA-seq, ATAC-seq) * Independently execute molecular biology protocols, including molecular cloning, flow cytometry, quantitative PCR, dd PCR * Troubleshoot technical barriers in the generation of high quality NGS libraries, from library delivery to cell lines through NGS library generation * Review and analyze data, participating in quality control and troubleshooting of processes and results * Contribute to the development of new protocols as needed * Present results and summarize progress to help frame internal decision-making * Comply with SOPs, good laboratory practices, and regulatory requirements * Adhere to a team schedule and individual time management * Maintain accurate laboratory documentation using established methods * Other duties as assigned Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects managements assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned. Required Education and Experience * Bachelors degree in Cell Biology, Genetics, Synthetic Biology, Bioengineering, Genomics, Molecular Biology, Bioinformatics, or related field * 6 years of relevant experience Preferred Education and Experience * Masters degree in Cell Biology, Genetics, Synthetic Biology, Bioengineering, Genomics, Molecular Biology, Bioinformatics, or related field * 8+ years of relevant experience * Experience in a TechBio setting where wet lab experiments primarily serve to build AI models * Experience optimizing pooled high throughput screening workflows * Experience performing molecular biology methods including molecular cloning (such as restriction cloning, Gibson Assembly, Golden Gate assembly, plasmid prep) * Experience cloning complex libraries is a plus * RNA isolation, DNA isolation, and PCR * Track-record of being an effective team member * Competence and ability to work in a molecular biology/cell culture laboratory * Experience with nucleic acid sequencing, especially custom amplicon sequencing * Experience performing cell biology methods including mammalian cell culture, murine embryonic stem cell culture, primary cell culture, nucleofection, and lipofection Physical Demands * Fine motor movements in fingers/hands to operate computers and other office/lab equipment Work Environment * Frequently required to sit, stand, walk, stoop, kneel or reach * Possible exposure and handling of laboratory animals * Laboratory atmosphere - possible exposure to chemical, biological or other hazardous substances Position Type/Expected Hours of Work * This role requires onsite work and is expected to work onsite for the majority of the working hours. We are a Washington State employer, and the primary work location for Allen Institute employees is 700 Dexter Ave N.; any remote work must be performed in Washington State. Travel * The successful candidate may be invited to attend occasional national and international conferences Additional Comments * Please note, this opportunity offers relocation assistance * Please note, this opportunity may offer work visa sponsorship Annualized Salary Range * $92,250 - $114,100 * * Final salary depends on required education for the role, experience, and level of skills relevant to the role, along with work location, where applicable. Benefits * Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institutes Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institutes 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institutes benefits offering are located at the following link to the Benefits Guide: