Associate Director jobs at Alnylam Pharmaceuticals - 57 jobs

A biopharmaceutical company is seeking an Associate Director, Compliance Business Partner to support compliance initiatives for its cell and gene, and kidney teams. This hybrid role involves advising on compliance strategies, conducting training, and maintaining knowledge of industry regulations. Candidates should have a law degree and 3-6 years of experience, demonstrating strong communication and project management skills. The position offers competitive pay and flexibility in a dynamic environment. #J-18808-Ljbffr

point of contact for business colleagues for these activities, will support department initiatives globally and must have knowledge of the biotechnology/pharmaceutical industry, anti-bribery/anti-corruption laws, and experience executing compliance-related investigations as well as assurance activities.**Key Duties and Responsibilities:** of knowledge of current and emerging laws and regulations and recent enforcement actions and **Knowledge and Skills:** Deep knowledge of risk assessment and mitigation as well as auditing and monitoring. Demonstrated ability to identify and mitigate risk.Healthcare fraud and abuse auditing and monitoring experience, with preference for experience in the biotechnology/pharmaceutical industry. Ability to develop and implement auditing and monitoring and other assurance activities and meet internal reporting requirements. Strong communication, presentation, collaboration, and influencing skills.Consummate team player with excellent judgment and interpersonal skills. Ability to communicate effectively with all levels of employees. Demonstrable experience taking ownership of projects and driving execution. Strong oral and written communication skills and the ability to collaborate cross-functionally. Strong analytical, organizational, and problem-solving skills. Excellent project management skills with the ability to manage multiple priorities simultaneously. Self-starter with demonstrated ability to meet goals; able to exercise sound judgment in escalating matters appropriately.Ability to work with large amounts of data to analyze information while still seeing the “big picture”. workplan development and investigative interviewing experience, with preference for experience in the biotechnology/pharmaceutical industry. Knowledge of biotech/pharmaceutical industry regulations, applicable local anti-bribery/anti-corruption laws and extensive experience working for biotechnology/pharmaceutical companies on these issues.**Education and Experience:** Typically requires 8-10 years experience focused on biotech or pharmaceutical industry in private practice/consulting, in-house, or a combination, or the equivalent combination of education and experience.Ability to travel approximately 15-20% of time.Experience with anti-bribery/anti-corruption laws and pharmaceutical regulations and Operations and project management experience. Proficiency in MS Office (especially XLSX and PPT).Advanced English language skills. The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.In this Hybrid-Eligible role, you can choose to be designated as: 1. **Hybrid**: work remotely up to two days per week; **or select** 2. **On-Site**: work five days per week on-site with ad hoc flexibility. #J-18808-Ljbffr

develops and provides strategic direction and leads daily operations of the US care management team supporting the US, Heme Business Unit. This individual will represent the US on the global cross-functional manufacturing team, developing slot allocation policies, managing exceptions processes, and managing system/manufacturing capacity. This individual will also play a key role in ensuring exceptional support is provided to our customers by our care manger team. This critical role will be highly cross functional within Vertex with the goal of providing industry-leading patient support through patient facing interactions and logistical coordination.Exceptional leadership and collaboration skills, as well as a strategic mindset are essential to the role. Strong partnerships will be required with internal functions such as finance, supply chain, manufacturing, IT, and other commercial colleagues. This individual will report to the Head of US Heme Patient Support. **Key Responsibilities:** Clear and consistent communication of roles, responsibilities, and performance expectations Daily monitoring to ensure consistent execution of all program requirements Consistent refinement and development of the CM role to ensure provision of impactful support in the logistical coordination of support activities and customer relationship development Support US OMstrategy and process optimization to ensure the processes support global OM goals and the best possible customer experience including but not limited to:System requirements (VCP and BEACON) Oversight and optimization of CM OM roles and responsibilities EHR and portal system requirements (VCP and BEACON)**Qualifications:** Strong customer service focus and the ability to act with urgency to respond to customer needs CGT experience preferred 5+ years' experience as impactful people-leader preferably in the biotech/pharma environment Excellent communication, interpersonal, and leadership skills Ability to act with urgency to ensure time-critical activities are completed while ensuring all stakeholders are on-board and have clarity around the goals and objectives Business savviness and ability to streamline processes and find opportunities for improvement Must be able to effectively work in a fast-paced environment, with strong time-management skills10+ year's work experience in the biotech/pharma environment Excellent communication, interpersonal, and leadership skills Ability to act with urgency to ensure time-critical activities are completed while ensuring all stakeholders are on-board and have clarity around the goals and objectives Ability to take complex situations and break them down into simple parts to enable stakeholders to make decisions / take actions Business savviness and ability to streamline processes and find opportunities for improvement Must be able to effectively work in a fast-paced environment, with strong time-management skills The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.In this Hybrid-Eligible role, you can choose to be designated as: 1. **Hybrid**: work remotely up to two days per week; **or select** 2. **On-Site**: work five days per week on-site with ad hoc flexibility. #J-18808-Ljbffr

The External Innovation (EI) Executive Director leads end‑to‑end identification, evaluation, and advancement of external opportunities that materially strengthen Vertex's R&D pipeline across modalities (e.g., small molecules, biologics, CGT, RNA, delivery platforms) and enabling technologies (e.g., discovery, translational, and manufacturing tools). The role orchestrates integrated, cross‑functional analyses and converts opportunity signals into clear, decision‑ready recommendations for EI governance (EI Science, BDSC) and the Executive Committee. Culture & talent: Foster an environment consistent with EI competencies (business‑minded leader, insight generator, influential communicator, trusted partner, change enabler, technical expert).**Required Education:** PhD (or equivalent advanced degree) and 15+ years of biotech/pharma experience spanning discovery and/or early development; or an equivalent combination of education and experience.**Required Experience**Proven ability to build and manage high‑performing analyst teams and to operate an integrated analysis model. **Required Knowledge & Skills**Business acumen: Valuation literacy; option‑value framing; scenario and risk modeling; ability to articulate value drivers and deal concepts (from partnerships to company creation/M&A). Influential communication: Executive‑quality narratives and visuals; clear storyline from problem framing to recommendation; ability to lead with facts and secure alignment. The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.In this Hybrid-Eligible role, you can choose to be designated as: 1. **Hybrid**: work remotely up to two days per week; **or select** 2. **On-Site**: work five days per week on-site with ad hoc flexibility. #J-18808-Ljbffr

The Compliance Associate Director assists in implementing and further enhancing the anti-corruption/anti-bribery Compliance program. Reporting to the Executive Director Head of Global Compliance Program Strategy, Assurance and Management, the Compliance Associate Director will be responsible for executing compliance-related investigations and supporting the company's global healthcare fraud and abuse assurance program and activities, including auditing and monitoring, both transactional and live. The Compliance Associate Director will serve as the initial point of contact for business colleagues for these activities, will support department initiatives globally and must have knowledge of the biotechnology/pharmaceutical industry, anti-bribery/anti-corruption laws, and experience executing compliance-related investigations as well as assurance activities. Key Duties and Responsibilities: Develops, implements, and continuously improves global auditing and monitoring plan. Sharing auditing and monitoring results with business partners and recommending corrective actions. Identifying and tracking themes and trends across audits and/or monitoring; preparing presentations to share results with OBIE leadership and the business. Manage and triage matters that come through the internal compliance Alert-Line tool and/or OBIE directly. Lead and support in the discrete and professional execution of compliance-related investigations. Collaborate with HR and Litigation colleagues in relation to compliance-related investigations. Develop compliance related training content Develops and maintains strong relationships with OBIE Business Partners, Internal Audit, Legal, as well as colleagues in other functional areas across the global organization. Maintains a high level of knowledge of current and emerging laws and regulations and recent enforcement actions and informs and educates business units with tailored communications. Support continuous improvement of the Global Compliance Program. Knowledge and Skills: Deep knowledge of risk assessment and mitigation as well as auditing and monitoring. Demonstrated ability to identify and mitigate risk. Healthcare fraud and abuse auditing and monitoring experience, with preference for experience in the biotechnology/pharmaceutical industry. Ability to develop and implement auditing and monitoring and other assurance activities and meet internal reporting requirements. Strong communication, presentation, collaboration, and influencing skills. Consummate team player with excellent judgment and interpersonal skills. Ability to communicate effectively with all levels of employees. Demonstrable experience taking ownership of projects and driving execution. Strong oral and written communication skills and the ability to collaborate cross-functionally. Strong analytical, organizational, and problem-solving skills. Excellent project management skills with the ability to manage multiple priorities simultaneously. Self-starter with demonstrated ability to meet goals; able to exercise sound judgment in escalating matters appropriately. Ability to work with large amounts of data to analyze information while still seeing the “big picture”. Investigation workplan development and investigative interviewing experience, with preference for experience in the biotechnology/pharmaceutical industry. Confidence and professionalism to handle difficult conversations and discretion on sensitive matters. Knowledge of biotech/pharmaceutical industry regulations, applicable local codes, and anti-bribery/anti-corruption laws and extensive experience working for biotechnology/pharmaceutical companies on these issues. Education and Experience: Bachelor's degree Typically requires 8-10 years experience focused on biotech or pharmaceutical industry in private practice/consulting, in-house, or a combination, or the equivalent combination of education and experience. Ability to travel approximately 15-20% of time. CPA, CFE or JD preferred Experience with anti-bribery/anti-corruption laws and pharmaceutical regulations and guidance's preferred Operations and project management experience. Demonstrated strong commitment to compliance, ethics, and accountability. Flexibility to work in a fast paced and dynamic work environment with a strong work ethic and positive attitude. Proficiency in MS Office (especially XLSX and PPT). Advanced English language skills. #HYBRID #LI-DB1 Pay Range: $168,000 - $252,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

We are seeking a visionary People Research Associate Director to lead the design and execution of high-impact research initiatives that shape workforce strategy and elevate organizational effectiveness. This role demands deep expertise in experimental methods, program evaluation, and storytelling with data. The People Research Associate Director will hold a PhD in a relevant field and bring a strong track record of translating complex research into actionable insights for senior leadership. Key Duties and Responsibilities: Lead End-to-End Research Design Architect and execute research studies to evaluate the effectiveness of HR programs, policies, and interventions. Plan, design and conduct experiments to understand employee sentiment, behaviors and motivation Drive Evidence-Based Decision Making Translate research findings into actionable insights that inform strategic decisions across HR and business units. Influence policy and program design through data-driven recommendations grounded in behavioral science and organizational psychology. Collaboration: Partner with cross-functional teams, including People Business Partners, to provide evidence-based consultation and support decision-making. Knowledge Management: Stay current with the latest developments in people science, research methods, and relevant technologies to ensure the rigor of the work. Foster a Culture of Inquiry Serve as a thought leader and internal consultant on research methodology, experimental design, and causal inference. Mentor analysts and HR partners in research best practices, elevating the organization's analytical maturity Knowledge and Skills: Ability to manage, prioritize and lead numerous projects simultaneously Excellent communication skills (to technical and non-technical audiences) and thought leadership experience Demonstrated ability to develop strong cross-functional partnerships and maintain a sound sense of purpose and direction in a changing organization Deep understanding of data mining, machine learning, data modeling and ONAExperience with visualization tools and statistical packages (SAS, R, Tableau, PowerBI) and SQL Ability to travel up to 25% Strategic Analytics & Reporting This role will also serve as a strategic partner in translating data into workforce insights: Workforce Planning & Predictive Modeling Develop and maintain predictive models to forecast headcount, attrition risk, internal mobility, and talent pipeline health. Collaborate with workforce planning teams to align modeling outputs with business strategy. Integrated Reporting Ecosystem Design and deliver dashboards, scorecards, and executive-level reports that synthesize data from HRIS, survey platforms, and external benchmarks. Ensure reporting is timely, accurate, and tailored to stakeholder needs. Data Storytelling & Executive Communication Distill complex analytical findings into clear, compelling narratives that resonate with senior leaders. Use visualization tools and storytelling techniques to make data accessible and actionable. Cross-Functional Collaboration Partner with HRBPs, Talent COEs, Finance, and Strategy teams to embed analytics into decision-making processes. Act as a bridge between technical teams and business leaders to ensure insights are understood and applied. Governance & Data Integrity Champion data quality, privacy, and ethical use of employee data. Collaborate with HR Technology and Compliance teams to uphold governance standards and ensure responsible analytics practices. Education and Experience: PhD in Industrial/Organizational Psychology, Behavioral Economics, Sociology, or a related field is required. 8-10 years of experience in HR analytics, workforce research, or organizational development. Knowledge of the latest trends and best practices in people research. Experience with both qualitative and quantitative research methods. Proficiency in statistical software (e.g., R, Python, SPSS, SAS) and data visualization tools (e.g., Tableau, Power BI). Familiarity with HRIS platforms (e.g., Workday) and data governance frameworks. Exceptional analytical thinking and problem-solving skills. Ability to distill complex concepts into simple, impactful messages. Strong communication and stakeholder management skills. #LI-EE1 #LI-Hybrid Pay Range: $162,400 - $243,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

To advance the development of transformative therapies for people with serious and life-threatening diseases, we are seeking an experienced computational biologist to lead the Boston-based computational genomics team, as part of the global Data and Computational Sciences organization. You and your team will focus on making biological discoveries by leveraging large-scale genomic and human genetic data to advance our drug discovery and development programs. As the leader of a team of 5, you will partner with leadership at the Boston Research site and disease project teams to drive project success in a fast-paced environment in areas such as target validation, pre-clinical model development, and characterization of novel therapeutics. You will also work closely with leaders across the global computational genomics teams and the Data and Computational Sciences department to develop technical best practices, define future directions for the team, and contribute to strategic initiatives. This is an on-site or hybrid eligible position requiring at least 3 days/week onsite. Key responsibilities: As the Computational Genomics team lead for Boston Research, you will work with your team members and disease project teams to identify and prioritize key project questions, design genomic studies, and interpret results to drive project progress. As a part of the global leadership for the Computational Genomics team, work across sites to prioritize global needs to maximize impact across the global research portfolio. Oversee computational genomic activities of your team, including providing scientific guidance, resource management, and leadership to ensure impactful and timely completion of studies, with adherence to data integrity and documentation policies. Ensure continuous talent development to attract, retain, and develop your team members. Partner across the rest of the Data & Computational Sciences department to prioritize, develop, and evolve computational methods and best practice guidelines for key analyses. Establish and maintain productive relationships with key stakeholders such as the Boston Research leadership across the organization. Knowledge and Skills: Advanced understanding in the fields of genomics, human genetics, statistics and/or computational biology, such as bulk and single cell transcriptomics, pooled variant screening, genome-wide association studies. A proven track record in the analysis, visualization, and interpretation of large-scale genomic data in a drug development context. Excellent scientific critical thinking, with the ability to understand the value, risks, and challenges of various approaches, synthesize and interpret complex data, and propose recommendations to drive forward progress. Demonstrated ability to work across cross-functional teams, ensuring proactive collaboration and timely progress. Superior communication skills demonstrating confidence and versatility in presenting verbally to diverse audiences and writing technical documents, including experience presenting to senior and executive leadership. A team-oriented growth mindset that welcomes feedback from others and supports other team members; a positive attitude that enthusiastically tackles and overcomes challenges. Highly skilled in mentoring others, resolving technical problems, maintaining procedural and ethical standards, and cultivating healthy team morale. Education and Experience: PhD degree (or Master's degree) in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field with 5+ years (or 8+ years for Master's degree) of productive, relevant industry experience and 2 years of management experience, or the equivalent combination of education and experience. Demonstrated leadership abilities, such as management of a high-performing team, leadership of a scientific project, mentorship of junior scientists. #LI-KM1 #LI-Hybrid Pay Range: $172,000 - $258,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking to hire a Brand Analytics & Reporting, Associate Director, Kidney to join the North America Forecasting, Analytics and Insights team in the Commercial organization. This individual will provide national and sub-national analytics support for the Kidney Business Unit (BU), with an initial focus on povetacicept (pove), through activities such identifying and quantifying potential market barriers and opportunities, quantitative and qualitative performance tracking and reporting, and go-to-market analysis. In addition, this individual will serve as an SME on available underlying data, and support build-out and optimization of analytics ready data sets (ARD). The ideal candidate must be a skilled and experienced individual contributor, with a demonstrated ability to communicate complicated concepts to a wide variety of stakeholders. This candidate must possess a high degree of attention to detail and accuracy in creating deliverables and must be self-directed in engaging with colleagues. Additionally, this candidate must be able to strategize, collaborate, and manage relationships with our many cross-functional partners. Key Duties and Responsibilities: * Work collaboratively within Kidney disease area (DA) analytics vertical, and with Kidney BU stakeholders, to create comprehensive analytics plans aimed at delivering actionable insights * Develop and leverage a deep understanding of all available data sets, and work with cross-functional analytics & technology partners to ingest, process, and analyze data for reporting and analytics * Lead creation and administration of commercial KPI dashboards with Kidney BU leadership (marketing and sales) as primary stakeholders. Initial scope will focus on pove performance, with potential future assets to follow * Contribute to answering ad-hoc analytics questions as they arise from Kidney BU and other stakeholders; work with BU stakeholders to understand needs, and propose/align on appropriate data & analytics approaches * Develop & continuously improve framework for establishing goals and measuring execution pull-through of new wins (e.g., formulary approvals), present performance against goals to leadership * Serve as an internal team SME to elevate analytics capabilities within the Forecasting, Analytics, and Market Research team through existing expertise and ongoing self-education of best-in-class approaches * Work collaboratively with cross functional stakeholders including but not limited to US Marketing, Global Marketing, US Market Access, Finance, Commercial Operations, Supply chain, etc. Knowledge and Skills: * Proficiency with complex modeling and analyzing and developing insights from large data sets, leveraging relevant tools such as SQL, python, R, etc. * Well-rounded understanding of promotional strategies and market access dynamics with demonstrated ability to combine with analytics to drive business decision-making * Proficiency working with wide array of commercial pharma data sets, specifically including specialty pharmacy data (e.g., deidentified patient-level transactional data), internally generated sales / marketing data (e.g. field call data from CRM), and also IQVIA data (or equivalent from different data vendor) such as XPONENT PlanTrak, DDD, LAAD (patient claims data) * Experience working on products in complex and competitive markets * Strong analytical and business acumen: intellectual curiosity, motivation and ability to structure problems, diagnose issues and triangulate with multiple approaches while keeping sight of the "big picture" * Experience working with senior leadership to support insights generation and communication, advanced analytics & modeling, and commercial launch planning * Ability to quickly and thoughtfully adapt to new and evolving business and planning needs Education and Experience: * Bachelor's degree in quantitative discipline required (e.g., Engineering, Statistics, Economics, Finance, Business Analytics) or equivalent experience * 8 years of experience in the pharmaceutical or biotech industry, 6+ years of insights, analytics and reporting is required. Pay Range: $157,800 - $236,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking to hire an Associate Director, Pain Strategic Brand Analytics to join the North America Forecasting, Analytics and Market Research team in the Commercial organization. This role will provide analytics support for strategic initiatives throughout the full evaluation, execution, and measurement lifecycle of the initiative. Additionally, this individual will support the ongoing analytics measuring execution pull-through of pain BU wins (payer, provider, etc.) and design & operate analytical approaches to identify & quantify drivers, barriers, and opportunities in the market using advanced methods. Analytics work will span functions within the BU including Marketing, Market Transformation, and Strategic Accounts, and will include collaboration with Market Access, Field, and Omnichannel Analytics. The ideal candidate must be a skilled and experienced individual contributor, with a demonstrated ability to communicate complicated concepts to a wide variety of stakeholders. This candidate must possess a high degree of attention to detail and accuracy in creating deliverables and must be self-directed in engaging with colleagues. Additionally, this candidate must be able to strategize, collaborate, and manage relationships with our many cross-functional partners. Key Duties and Responsibilities: * Work with the Director, Pain Performance Analytics & Forecasting and Pain BU stakeholders to identify existing or planned initiatives that would benefit from additional analytics support, and collaboratively create analytics plans to deliver required insights * Develop & continuously improve framework for establishing goals and measuring execution pull-through of new wins (e.g. new hospital formulary approvals); present performance against goals during commercial performance meetings * Design & operate an analytical engine to identify & quantify drivers, barriers, and opportunities in the market using advanced statistical / ML methodology; synthesize findings for business stakeholders on a regular basis for evaluation & action * Contribute to answering ad-hoc analytics questions as they arise from the BU; work with BU stakeholders to understand their questions and most appropriate data & analytics approach * Serve as an internal team SME to elevate analytics capabilities within the Forecasting, Analytics, and Market Research team through existing expertise and ongoing self-education of best-in-class approaches * Work collaboratively with cross functional stakeholders including but not limited to US Marketing, Global Marketing, US Market Access, US Finance, Commercial Sales Operations, etc. Knowledge and Skills: * Proficiency with complex modeling and analyzing and developing insights from large data sets, leveraging relevant tools such as SQL, python, R, etc. * Proficiency working with wide array of commercial pharma data sets, including data sets such as IQVIA (or equivalent from different data vendor) XPONENT PlanTrak, DDD, LAAD (patient claims data), and internally generated sales / marketing data (e.g. field call data from CRM) * Experience with advanced analytics and machine learning modelling including time series modelling, XGBoost, predictive modelling, regression, and other statistical modelling algorithms * Experience working on products competing in large, complex markets and experience across both retail & hospital products * Strong analytical and business acumen: intellectual curiosity, motivation and ability to structure problems, diagnose issues and triangulate with multiple approaches while keeping sight of the "big picture" * Experience working with senior leadership to support insights generation and communication, advanced analytics & modeling, and commercial launch planning * Ability to quickly and thoughtfully adapt to new and evolving business and planning needs Education and Experience: * Bachelor's degree in quantitative discipline required (e.g., Engineering, Statistics, Economics, Finance, Business Analytics) or equivalent experience * 7-10 years of experience in the pharmaceutical or biotech industry, 6+ years of insights, analytics and/or reporting is required. Pay Range: $157,800 - $236,700 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking an Associate Director of Patient Support & Engagement Analytics to lead analytics initiatives that optimize patient services and programs, primarily supporting therapies for hemoglobinopathies such as sickle cell disease and beta thalassemia. This role will leverage data-driven insights, patient journey analytics, and predictive modeling to enhance patient engagement and improve operational efficiency across Vertex's patient support ecosystem. The ideal candidate is a highly skilled individual contributor with a proven ability to translate complex concepts into clear, actionable insights for diverse stakeholders. They demonstrate exceptional attention to detail and accuracy in deliverables, while working independently and proactively engaging with colleagues. In addition, this candidate excels at strategic thinking, collaboration, and relationship management across multiple cross-functional teams. Key Duties and Responsibilities Develop and execute the analytics strategy and approach, ensuring alignment with the business objectives. Create KPIs, dashboards, and reporting frameworks to monitor care manager performance, program effectiveness and patient experience. Utilize advanced statistical techniques, machine learning models, and data visualization tools (Tableau, Power BI) to inform strategic decisions. Partner with Patient Services, Marketing, and Commercial Operations to identify actionable insights that improve patient readiness, streamline onboarding, and deliver a positive treatment experience. Present findings to program/brand leadership and influence data-driven decision-making across the organization. Champion innovation by piloting new analytical methodologies and visualization tools to enhance insights delivery and operational excellence. Ensure compliance with HIPAA, data privacy regulations, and Vertex's data governance standards. Partner with Data Engineering team to define and optimize data infrastructure (data warehouse, data lake) for scalable analytics solutions. Manage external vendors and oversee data quality assurance for patient support analytics. Knowledge and Skills Critical thinker with a demonstrated ability to identify key trends, synthesize complex data, and translate findings into actionable recommendations. Advanced analytical expertise with proficiency in Excel, SQL, and Power BI; familiarity with Python and Snowflake is a strong plus. Proven ability to collaborate effectively with internal teams and external partners to generate insights and support strategic decision-making. Demonstrated ability to evaluate and prioritize competing requests, ensuring timely delivery of multiple concurrent workstreams. Exceptional communication skills, both written and verbal, with the ability to present insights clearly and persuasively to cross-functional teams and mid-level leadership. Highly flexible, comfortable navigating ambiguity and thriving in a fast-paced, dynamic environment. Domain expertise in cell and gene therapy or experience supporting hemoglobinopathies is a strong plus. Education and Experience Bachelor's degree in a quantitative discipline (e.g. Data Science, Statistics, Economics, Healthcare Analytics, or related field). Typically requires 8+ years of experience in pharma/biotech analytics, with a focus on patient support, commercial analytics, forecasting, or commercial operations. Strong experience working with data infrastructure, BI tools, and leading cross-functional analytics projects. Pay Range: $157,800 - $236,700 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking to hire an Associate Director, Pain Strategic Brand Analytics to join the North America Forecasting, Analytics and Market Research team in the Commercial organization. This role will provide analytics support for strategic initiatives throughout the full evaluation, execution, and measurement lifecycle of the initiative. Additionally, this individual will support the ongoing analytics measuring execution pull-through of pain BU wins (payer, provider, etc.) and design & operate analytical approaches to identify & quantify drivers, barriers, and opportunities in the market using advanced methods. Analytics work will span functions within the BU including Marketing, Market Transformation, and Strategic Accounts, and will include collaboration with Market Access, Field, and Omnichannel Analytics. The ideal candidate must be a skilled and experienced individual contributor, with a demonstrated ability to communicate complicated concepts to a wide variety of stakeholders. This candidate must possess a high degree of attention to detail and accuracy in creating deliverables and must be self-directed in engaging with colleagues. Additionally, this candidate must be able to strategize, collaborate, and manage relationships with our many cross-functional partners. Key Duties and Responsibilities: Work with the Director, Pain Performance Analytics & Forecasting and Pain BU stakeholders to identify existing or planned initiatives that would benefit from additional analytics support, and collaboratively create analytics plans to deliver required insights Develop & continuously improve framework for establishing goals and measuring execution pull-through of new wins (e.g. new hospital formulary approvals); present performance against goals during commercial performance meetings Design & operate an analytical engine to identify & quantify drivers, barriers, and opportunities in the market using advanced statistical / ML methodology; synthesize findings for business stakeholders on a regular basis for evaluation & action Contribute to answering ad-hoc analytics questions as they arise from the BU; work with BU stakeholders to understand their questions and most appropriate data & analytics approach Serve as an internal team SME to elevate analytics capabilities within the Forecasting, Analytics, and Market Research team through existing expertise and ongoing self-education of best-in-class approaches Work collaboratively with cross functional stakeholders including but not limited to US Marketing, Global Marketing, US Market Access, US Finance, Commercial Sales Operations, etc. Knowledge and Skills: Proficiency with complex modeling and analyzing and developing insights from large data sets, leveraging relevant tools such as SQL, python, R, etc. Proficiency working with wide array of commercial pharma data sets, including data sets such as IQVIA (or equivalent from different data vendor) XPONENT PlanTrak, DDD, LAAD (patient claims data), and internally generated sales / marketing data (e.g. field call data from CRM) Experience with advanced analytics and machine learning modelling including time series modelling, XGBoost, predictive modelling, regression, and other statistical modelling algorithms Experience working on products competing in large, complex markets and experience across both retail & hospital products Strong analytical and business acumen: intellectual curiosity, motivation and ability to structure problems, diagnose issues and triangulate with multiple approaches while keeping sight of the “big picture” Experience working with senior leadership to support insights generation and communication, advanced analytics & modeling, and commercial launch planning Ability to quickly and thoughtfully adapt to new and evolving business and planning needs Education and Experience: Bachelor's degree in quantitative discipline required (e.g., Engineering, Statistics, Economics, Finance, Business Analytics) or equivalent experience 7-10 years of experience in the pharmaceutical or biotech industry, 6+ years of insights, analytics and/or reporting is required. Pay Range: $157,800 - $236,700 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking to hire a Brand Analytics & Reporting, Associate Director, Kidney to join the North America Forecasting, Analytics and Insights team in the Commercial organization. This individual will provide national and sub-national analytics support for the Kidney Business Unit (BU), with an initial focus on povetacicept (pove), through activities such identifying and quantifying potential market barriers and opportunities, quantitative and qualitative performance tracking and reporting, and go-to-market analysis. In addition, this individual will serve as an SME on available underlying data, and support build-out and optimization of analytics ready data sets (ARD). The ideal candidate must be a skilled and experienced individual contributor, with a demonstrated ability to communicate complicated concepts to a wide variety of stakeholders. This candidate must possess a high degree of attention to detail and accuracy in creating deliverables and must be self-directed in engaging with colleagues. Additionally, this candidate must be able to strategize, collaborate, and manage relationships with our many cross-functional partners. Key Duties and Responsibilities: Work collaboratively within Kidney disease area (DA) analytics vertical, and with Kidney BU stakeholders, to create comprehensive analytics plans aimed at delivering actionable insights Develop and leverage a deep understanding of all available data sets, and work with cross-functional analytics & technology partners to ingest, process, and analyze data for reporting and analytics Lead creation and administration of commercial KPI dashboards with Kidney BU leadership (marketing and sales) as primary stakeholders. Initial scope will focus on pove performance, with potential future assets to follow Contribute to answering ad-hoc analytics questions as they arise from Kidney BU and other stakeholders; work with BU stakeholders to understand needs, and propose/align on appropriate data & analytics approaches Develop & continuously improve framework for establishing goals and measuring execution pull-through of new wins (e.g., formulary approvals), present performance against goals to leadership Serve as an internal team SME to elevate analytics capabilities within the Forecasting, Analytics, and Market Research team through existing expertise and ongoing self-education of best-in-class approaches Work collaboratively with cross functional stakeholders including but not limited to US Marketing, Global Marketing, US Market Access, Finance, Commercial Operations, Supply chain, etc. Knowledge and Skills: Proficiency with complex modeling and analyzing and developing insights from large data sets, leveraging relevant tools such as SQL, python, R, etc. Well-rounded understanding of promotional strategies and market access dynamics with demonstrated ability to combine with analytics to drive business decision-making Proficiency working with wide array of commercial pharma data sets, specifically including specialty pharmacy data (e.g., deidentified patient-level transactional data), internally generated sales / marketing data (e.g. field call data from CRM), and also IQVIA data (or equivalent from different data vendor) such as XPONENT PlanTrak, DDD, LAAD (patient claims data) Experience working on products in complex and competitive markets Strong analytical and business acumen: intellectual curiosity, motivation and ability to structure problems, diagnose issues and triangulate with multiple approaches while keeping sight of the “big picture” Experience working with senior leadership to support insights generation and communication, advanced analytics & modeling, and commercial launch planning Ability to quickly and thoughtfully adapt to new and evolving business and planning needs Education and Experience: Bachelor's degree in quantitative discipline required (e.g., Engineering, Statistics, Economics, Finance, Business Analytics) or equivalent experience 8 years of experience in the pharmaceutical or biotech industry, 6+ years of insights, analytics and reporting is required. Pay Range: $157,800 - $236,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

As Associate Director of Cell & Gene Therapy Forecasting, you will lead global forecasting activities for Vertex's rapidly evolving cell and gene therapy portfolio, with an emphasis on the Heme franchise and the emerging Type 1 Diabetes program. You will develop robust forecasts across time horizons, partner cross-functionally to shape commercial strategy, and ensure the integration of the latest market, competitive, and clinical intelligence. You will collaborate closely with commercial, medical, finance, manufacturing, operations, and marketing science partners to deliver high-quality analytical support that informs business decisions, scenario planning, and the long-range portfolio outlook. This role requires demonstrated excellence in in-line forecasting, experience working in complex or rapidly evolving therapeutic areas, and the ability to operate with both strategic vision and operational precision. You will help shape forecasting frameworks for long-term, potentially curative therapies where traditional analogs and market behaviors may not apply-requiring creativity, methodological innovation, and strong collaborative leadership. Key Duties and Responsibilities Forecast Leadership & Strategy Lead development, refinement, and maintenance of long-range global revenue and demand forecasts for the Heme and Type 1 Diabetes commercial franchises. Build forecasting frameworks suited for disruptive, potentially curative therapies, integrating epidemiology, patient journey/treatment dynamics, operational constraints, and market evolution. Serve as a trusted advisor to senior leaders within Global Commercial Strategy, providing objective, data-driven insights to support decision-making across brand, portfolio, and corporate levels. Drive long-range forecasting activities (LRP), annual planning, and scenario modeling to support business cases, supply planning, manufacturing strategy, and strategic prioritization. Cross-Functional Collaboration & Insight Integration Partner closely with Marketing Science, HEOR, Market Access, Medical Affairs, Commercial Development, and Finance to synthesize and integrate insights into forecast models, while ensuring alignment with near-term regional forecasts. Collaborate with marketing science colleagues and external vendors to ensure primary market research is appropriately incorporated into forecasting assumptions and scenario analyses. Work with competitive intelligence teams to evaluate pipeline evolution, competitive launches, and environmental shifts affecting adoption curves and long-term penetration. Coordinate with supply chain and manufacturing partners to align forecasts with capacity planning and operational constraints unique to cell and gene therapy modalities. Analytics, Modeling, and Reporting Develop and maintain advanced forecasting models that appropriately reflect uncertainties, sensitivities, and key market drivers. Produce high-quality deliverables including forecast dashboards, scenario summaries, business cases, and communication materials for leadership discussions. Ensure methodological transparency, strong version control, and best practices in documentation and model governance. Proactively identify emerging trends, risks, and opportunities, and translate them into strategic implications for commercial and enterprise-level planning. Portfolio & Enterprise Impact Support portfolio-wide analytics, helping harmonize forecasting approaches across cell and gene therapy programs. Provide input into long-term strategic planning activities, opportunity assessments, and resource prioritization across the non-CF pipeline. Represent forecasting in cross-functional working groups and governance forums, ensuring alignment across global, regional, and local teams. Knowledge and Skills: Deep expertise with in-line forecasting in the pharmaceutical or biotechnology industry; experience with specialty, rare disease, or cell & gene therapy markets strongly preferred. Strong command of forecast modeling approaches across all stages (early clinical, launch, in-line). Ability to translate complex scientific, clinical, and quantitative information into clear, strategic insights. Excellent communication skills, with the ability to influence senior stakeholders and articulate assumptions, risks, and recommendations. Proficiency with analytical tools (Excel, forecasting platforms, Power BI or similar visualization tools); experience with simulation, sensitivity analysis, or advanced modeling a plus. Demonstrated experience operating in highly cross-functional environments and managing diverse stakeholder needs. Comfort with ambiguity and a problem-solving mindset well-suited to first-in-class or curative therapies where traditional analogs may not exist. Strong project management skills with the ability to handle multiple priorities with speed and precision. Education and Experience: Bachelor's degree in a quantitative, scientific, business, or healthcare-related field required; MBA, MS, MPH, or other advanced degree preferred. 7-10+ years of pharmaceutical/biotech forecasting or commercial analytics experience, with at least 3+ years in in-line forecasting roles. Experience supporting global or multi-region commercial organizations preferred. Prior experience in cell and gene therapy, rare disease, or advanced modalities is advantageous but not required. Demonstrated track record of delivering high-quality forecasts that inform commercial, financial, or strategic decision-making. Pay Range: $161,900 - $242,900 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Associate Director, Strategy and Operations, US Market Access is a key partner and advisor to the VP US Market Access and Market Access Leadership Team (MALT) on a variety of strategic, operational, and organizational matters. The role requires both strategic thinking as well as the ability to drive operational execution through preparing, implementing, and effectively managing tactical initiatives. The ideal candidate is a highly motivated and highly organized individual with exceptional emotional intelligence, communication skills and judgment with the ability to manage complex details, understand the business, and drive action. This role reports directly into the Vice President of US Market Access. Key Responsibilities: Support the US MALT in developing and implementing decisions impacting team operations and strategic direction for the US Market Access team Support the VP in defining and developing high-impact executive, cross-functional and cross-team communications Develops and maintains department budget in collaboration with the leadership team and finance to provide transparency into spend, understand and explain forecast variance, and manage tools to ensure maximization of budget Lead or support critical business processes relevant to US Market Access, including evolution of organizational design, Long Range Planning and annual Business Planning Lead and/or manage special projects and high-profile initiatives, as appropriate and aligned with critical business needs Quarterback development of Business Reviews, senior management presentations, team presentations and meetings Enhance processes for measuring and reporting progress on high-priority initiatives across the USMA team Lead after action reviews of high impact projects; provide recommendations for simplification of processes and systems. Identify and plan proactively address business needs to ensure success of team. Coordinate leadership team meetings and forums such as offsites and pull through of action items Ideate and coordinate pull-through of HR, talent development, and team-culture related initiatives and activities Contributes to the best practices of project management and departmental operations to support the continued success and evolution of the department Act as a liaison between cross functional colleagues to ensure alignment and coordination on a wide variety of cross-functional initiatives Qualifications: Bachelor's degree required 8+ years of progressive, relevant experience with demonstrated experience as a chief of staff, in project management, or organizing and directing multiple teams and departments Outstanding communication of information and ideas, both written and verbal, to diverse audiences; employs active listening skills Strong collaboration skills, with an ability to influence multiple stakeholders; builds mutual trust, respect and cooperation among team members Significant experience in managing complex project teams and proven ability to work in and influence a cross-functional team; solution-oriented mindset Excellent analytical and financial business planning skills Self-motivated; acts independently and prioritizes appropriately; embraces unexpected changes or challenges and drives to improved solutions Pay Range: $155,700 - $233,500 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Associate Director, GMP Operational Quality will provide leadership and quality oversight for contract testing laboratories (CTLs) supporting Vertex's biologics and combination product portfolio across development, PPQ, launch, and commercial lifecycle management. This role ensures that analytical testing, method execution, and data generated by external laboratories meet Vertex, global regulatory, and data integrity standards. Key Duties and Responsibilities: Serve as the primary QA lead for CTLs supporting release, stability, characterization, and device-related testing for Vertex's biologics and combination products. Provide quality oversight for analytical method qualification/validation, method transfer, and lifecycle management activities executed by CTLs. Review and approve analytical protocols, reports, testing plans, stability protocols, and Quality Agreements. Ensure investigations (OOS/OOT/OOE), deviations, CAPAs, and change controls originating from CTLs meet Vertex standards and are compliant with global GMP expectations. Lead quality reviews, performance assessments, and risk management activities for the external testing network. Conduct or oversee QA review of analytical data packages, COAs, stability trending, device analytical outputs, and raw data from CTLs. Ensure compliance with ALCOA+ principles and global data integrity guidelines. Partner with Analytical Development and QC to evaluate method performance, assay robustness, and analytical control strategies. Provide QA input into specification setting, control strategy development, and analytical comparability assessments. Support analytical method development activities by ensuring appropriate QA oversight during method lifecycle progression. Provide QA support during method transfers, PPQ readiness, and commercial launch activities. Ensure CTLs are prepared to support global commercial supply, including alignment with international regulatory expectations. Contribute QA expertise to device-related analytical programs, including testing strategies for drug-device combination products. Support CTL audits and regulatory inspections involving analytical methods, testing, or device-related analytics. Maintain and update Quality Agreements, ensuring alignment with evolving program and regulatory needs. Drive continuous improvement in Vertex's external testing oversight model, including procedures, metrics, and governance. Serve as a QA subject matter expert for analytical and device-related testing across biologics and combination product programs. Collaborate with CMC, Analytical Development, QC, MS&T, Device Engineering, QA Device, and Regulatory Affairs to ensure robust analytical control strategies. Represent QA in analytical lifecycle teams, technical forums, and program governance meetings. Knowledge and Skills: Demonstrated experience overseeing contract testing laboratories supporting biologics, sterile products, or combination products. Strong understanding of analytical method development, validation, transfer, and lifecycle management. Knowledge of biologics analytical control strategies, immunoassays, cell-based assays, potency assays, and device analytical requirements. Familiarity with combination product regulations (21 CFR Part 4), global GMPs, and data integrity expectations. Experience supporting clinical development through commercial supply, including PPQ, launch readiness, and post-approval changes. Excellent leadership, communication, and influencing skills in a highly matrixed environment. Experience with electronic document management systems (e.g., Veeva) Education and Experience: Bachelor's degree in a scientific or allied health field (or equivalent degree) Typically requires 8+ years of work experience, or the equivalent combination of education and experience #LI-hybrid Pay Range: $154,100 - $231,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking an experienced commercial leader to implement field sales and non-personal promotion tactics in support of the Pain Business Unit (BU). The Customer Strategy & Execution Lead (CSEL) will partner with North America commercial organization to implement the go-to-market (GTM) strategy and deliver customer solutions that meet the business needs. This role will work directly with the BU stakeholders, Field Operations Leads, Digital Operations Leads, Customer Data Management, and technical stakeholders to optimize HCP customer experience. This role reports to the Director, Customer Strategy & Execution Lead. Key Duties and Responsibilities: Partner with key business leaders to understand business strategy and translate to prioritized commercial operations needs to enable all customer-facing engagements for the Pain BU Build and strengthen relationships with key leaders (heads of BU, Marketing, Field) - become a trusted partner and have an ongoing, significant impact towards meeting / exceeding strategic business goals Define and lead portfolio of projects of field enablement and marketing campaigns, ensuring quality and timeliness of delivery while remaining within allocated budget limits Co-develop HCP and patient customer journey maps across Field Operations and Digital Operations Conduct periodic after-action reviews to identify gaps and forward-looking opportunities in evolving technologies and potential business process improvements in pursuit of driving efficiencies and exceeding business goals Budget management / accountability - plan and manage financial resources for field enablement, field customer-facing activities, non-personal promotion Create and manage an integrated brand engagement playbook that enables cross-functional teams to have a singular source for key strategic and executional insights and plans (targeting, approved messages, engagement planning) Lead quarterly business planning sessions and document outcomes to ensure alignment across BU leaders on key upcoming priorities to prioritize work for key cross-functional enablement teams (e.g., DTE, DSS) Active participation in recurring BU Leadership Team Meetings to provide strategic recommendations to drive brand growth and proactively identify any risks or dependencies related to field and marketing engagement Qualifications 8-10 years' experience working in delivering customer-facing programs with at least 6-8 years of industry experience Experience in commercial launch readiness, supporting launch planning across multiple systems including CRM, Digital Customer Engagement, Reporting & Analytics, and Digital Marketing, etc. Able to translate broad business strategies and functional priorities into effective operational goals and objectives; able to actively participate in strategic planning for the function Results oriented leader with a proven track record of on-time project delivery for large, cross-functional, and complex projects with stakeholders Exceptional written and verbal communication skills and ability to present in a clear and concise manner to all audiences Exceptional analytical, quantitative, problem-solving, and prioritization skills, including the development of business cases/ value propositions Substantial program/ project management, demand management, resource management and system life cycle expertise Education and Experience Bachelor's degree required Advanced degree preferred Pay Range: $155,200 - $232,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Associate Director is recognized as an expert in the principles and application of quality and regulatory compliance. The individual adapts to new and multiple projects, effectively ensuring alignment with corporate goals and compliance with regulatory requirements. This role is responsible for oversight and coordination of GMP activities in support of Commercial Release and serves as primary QA contact on cross-functional teams. The Associate Director manages and develops personnel and support department and functional activities. KEY DUTIES AND RESPONSIBILITIES: The responsibilities of this role may include, but are not limited to, the following: * Responsible for oversight of analytical activities in support of release of commercial products. * Collaborates with internal and external business partners to resolve complex quality issues to ensure compliant solutions in support of Analytical QA function. * Represents Analytical QA function at meetings with CMO/CTL/Suppliers. Drafts and enforces Quality Agreements between CMOs/Suppliers and Vertex. Supports inspection readiness and vendor management teams as needed. * Guides and conducts quality investigations, OOS/OOT investigations, deviations. Communicate any risks and gaps to management as known. * Reviews investigation reports and corrective action plans for adequacy and compliance. This includes escalation assessment, root cause analysis and product impact assessments for investigations resulting from deviations and OOS. May serve as an Escalation Lead. * Ensures appropriate CAPA actions are identified/evaluated and approves investigations/CAPA plans/actions. * Assesses and approves Change Controls. * May generate and analyze Laboratory Controls and other metrics for Operational Reviews, QLT's and QMR's. May provide support to Laboratory Control PON. * Provides support to implementation of QMS as relevant to Analytical QA functions. * Provides support to QA management with process improvement activities. Identifies and facilitates continuous improvement efforts and leads continuous improvement projects as assigned. * Provides tactics to address compliance gaps or determines enhancements to cross-functional quality systems. * Conducts review of procedures, SOP's and work instructions. * Supports and conducts data review and COA generation as needed. * Provides back-up support for other projects when needed. Assists with internal audits and external regulatory agency inspections when needed. * Responsible for the following activities related to people management responsibilities. o Talent Development and Coaching o Performance Management (goals, monitoring, reviews) o Monitoring /Supporting Employee Engagement o Accomplishing staff results by communicating job expectations, planning, coaching, training and developing personal growth opportunities through IDPs o Accountable to provide oversight of day-to-day operations o Assists with workforce planning/resource modeling PREFERRED QUALIFICATIONS: * Broad GxP Knowledge across Product lifecycle. In-depth knowledge of global GMP requirements. * Ability to think critically and strategically with clear goals in mind. * Strong team leadership skills with the ability to work in a fast-paced environment and meet quality, accuracy and timeliness objectives * Demonstrated ability to manage teams and to develop personnel. Demonstrated ability to mentor and guide staff and transfer technical knowledge and teaching quality management skills. * Demonstrated ability to work independently to provide QA advice for large, multifaceted * Demonstrated ability to evaluate quality matters and make complex decisions leveraging technical experience, advanced judgement and the analysis/synthesis of a variety of information; ability to work outside of precedent and takes a new perspective on existing solutions. * Ability to communicate cross-functionally to a wide variety of audiences, question stakeholders to understand their needs. * Successful track record influencing cross functional teams and gain alignment on proposed actions * Strong experience in leading Quality Events investigations, Root Cause Analysis (RCA), and CAPA implementation. * Demonstrated ability to independently lead cross-functional teams and to provide QA advice for large, multifaceted projects. * Strong laboratory/QC experience and understanding of various analytical techniques. * Ability to effectively organize and plan activities. * Experience in Presentations and Risk Management. * Operational QA experience in analytical or manufacturing setting is desired. EDUCATION AND EXPERIENCE: * Master's degree and 5-8 years of work experience in a scientific or allied health field, or Bachelor's degree in a scientific or allied health field and 10+ years of relevant work experience, or relevant comparable background We're enabling flexibility and choice between individuals and their managers to maintain our strong culture of collaboration and ensure a daily vibrancy within our sites globally. In this Hybrid or On-Site-Eligible role, you can choose to work: 1. Hybrid and work remotely up to two days per week; or select 2. On-Site and work 5 days per week with ad hoc flexibility. #LI-AR1 #LI-Hybrid Pay Range: $152,200 - $228,300 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Associate Director is recognized as an expert in the principles and application of quality and regulatory compliance. The individual adapts to new and multiple projects, effectively ensuring alignment with corporate goals and compliance with regulatory requirements. This role is responsible for oversight and coordination of GMP activities in support of Commercial Release and serves as primary QA contact on cross-functional teams. The Associate Director manages and develops personnel and support department and functional activities. KEY DUTIES AND RESPONSIBILITIES: The responsibilities of this role may include, but are not limited to, the following: • Responsible for oversight of analytical activities in support of release of commercial products. • Collaborates with internal and external business partners to resolve complex quality issues to ensure compliant solutions in support of Analytical QA function. •Represents Analytical QA function at meetings with CMO/CTL/Suppliers. Drafts and enforces Quality Agreements between CMOs/Suppliers and Vertex. Supports inspection readiness and vendor management teams as needed. •Guides and conducts quality investigations, OOS/OOT investigations, deviations. Communicate any risks and gaps to management as known. •Reviews investigation reports and corrective action plans for adequacy and compliance. This includes escalation assessment, root cause analysis and product impact assessments for investigations resulting from deviations and OOS. May serve as an Escalation Lead. • Ensures appropriate CAPA actions are identified/evaluated and approves investigations/CAPA plans/actions. •Assesses and approves Change Controls. •May generate and analyze Laboratory Controls and other metrics for Operational Reviews, QLT's and QMR's. May provide support to Laboratory Control PON. •Provides support to implementation of QMS as relevant to Analytical QA functions. •Provides support to QA management with process improvement activities. Identifies and facilitates continuous improvement efforts and leads continuous improvement projects as assigned. •Provides tactics to address compliance gaps or determines enhancements to cross-functional quality systems. •Conducts review of procedures, SOP's and work instructions. •Supports and conducts data review and COA generation as needed. •Provides back-up support for other projects when needed. Assists with internal audits and external regulatory agency inspections when needed. •Responsible for the following activities related to people management responsibilities. o Talent Development and Coaching o Performance Management (goals, monitoring, reviews) o Monitoring /Supporting Employee Engagement o Accomplishing staff results by communicating job expectations, planning, coaching, training and developing personal growth opportunities through IDPs o Accountable to provide oversight of day-to-day operations o Assists with workforce planning/resource modeling PREFERRED QUALIFICATIONS: •Broad GxP Knowledge across Product lifecycle. In-depth knowledge of global GMP requirements. •Ability to think critically and strategically with clear goals in mind. •Strong team leadership skills with the ability to work in a fast-paced environment and meet quality, accuracy and timeliness objectives •Demonstrated ability to manage teams and to develop personnel. Demonstrated ability to mentor and guide staff and transfer technical knowledge and teaching quality management skills. •Demonstrated ability to work independently to provide QA advice for large, multifaceted •Demonstrated ability to evaluate quality matters and make complex decisions leveraging technical experience, advanced judgement and the analysis/synthesis of a variety of information; ability to work outside of precedent and takes a new perspective on existing solutions. •Ability to communicate cross-functionally to a wide variety of audiences, question stakeholders to understand their needs. •Successful track record influencing cross functional teams and gain alignment on proposed actions •Strong experience in leading Quality Events investigations, Root Cause Analysis (RCA), and CAPA implementation. •Demonstrated ability to independently lead cross-functional teams and to provide QA advice for large, multifaceted projects. •Strong laboratory/QC experience and understanding of various analytical techniques. •Ability to effectively organize and plan activities. •Experience in Presentations and Risk Management. •Operational QA experience in analytical or manufacturing setting is desired. EDUCATION AND EXPERIENCE: •Master's degree and 5-8 years of work experience in a scientific or allied health field, or Bachelor's degree in a scientific or allied health field and 10+ years of relevant work experience, or relevant comparable background We're enabling flexibility and choice between individuals and their managers to maintain our strong culture of collaboration and ensure a daily vibrancy within our sites globally. In this Hybrid or On-Site-Eligible role, you can choose to work: 1. Hybrid and work remotely up to two days per week; or select 2. On-Site and work 5 days per week with ad hoc flexibility. #LI-AR1 #LI-Hybrid Pay Range: $152,200 - $228,300 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking a talented and motivated individual to join our US Kidney Business Unit to support the execution of US commercial diagnostic initiatives to ensure rapid diagnosis, effective treatment, and improved patient outcomes for our APOL1-mediated kidney disease (AMKD) program. This role will manage the existing APOL1 sponsored genetic testing program and will develop additional innovative pilot programs aimed at improving APOL1 diagnosis in the US. This role will require coordination across all internal stakeholders. We are seeking a candidate that has an in-depth understanding of the diagnostic and genetic testing industry, an innovative mindset, and the ability to thrive in a fast-paced, innovation-focused environment. This role reports to the Director, Diagnostic and Patient Finding Lead, AMKD. Key Duties and Responsibilities: Manage ongoing sponsored testing programs: - Manage day to day activities and joint meeting management - Manage contracts to ensure continuity of service - Monitor volume of test executed and yield - Work with vendor to assess trends, especially if associated with changes in yield - Work with vendor to define marketing/promotional strategy and ensure any content is reviewed appropriately - Update tracker to ensure accurate account of test executed - Manage data delivery and ensure appropriate data utilization - Support development of a dashboard to monitor diagnostic trends in the US, in collaboration with Diagnostic lead, SM, Diagnostic Data, and Legal/compliance Manage pilot programs aimed at increasing diagnosis for APOL1 testing in the US: - Manage all pilots initiating in the US, including vendor management - Attend meetings and send weekly status update to Diagnostic Lead - Work with vendors to crystallize success metrics and ensure ability to assess program performance by December '27 - Develop a tracking system to monitor success vs goal - Manage any content developed through these efforts in collaboration with vendors - In collaboration with Diagnostic Lead, identify best programs to scale in '27 Miscellaneous: - Attend conferences and man booth - ensure proper awareness for sponsored testing programs in collaboration with AD, unbranded lead - Prepare presentations & status updates to inform leadership of diagnostic program progress - Inform diagnostic strategy with insights coming from diagnostic programs & pilots - Conference attendance to inform dx strategy - Partner with Patient Advocacy to Identify additional initiatives to support diagnostic - Surveil the market to identify novel ways to improve diagnostic rate Knowledge and Skills: Proven track record of successfully managing vendors and working across a matrixed organization to achieve success Analytical mindset, with demonstrated ability to combine data, customers insights and market trends in clear actionable information Exceptional working knowledge of MS Office applications, including PPT, Excel and Word Experience in pharmaceutical marketing, or closely related field(s) (e.g., pharmaceutical sales, ad agency, etc.) OR experience in strategy consulting Nephrology experience is preferred Companion diagnostic or sponsored genetic testing experience is preferred Education and Experience: Bachelor's degree in marketing, business, or scientific degree 7+ year experience in diagnostics and /or biopharmaceutical industry Ability to travel 20% Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com