Associate Scientist jobs at Alnylam Pharmaceuticals - 51 jobs

Our company is a leading global biopharmaceutical company with a 125-year history of an inspiring mission to make discoveries that positively impact global healthcare. Our success is driven by putting patients first, operating with the highest integrity, and committing fully to our vision to make a difference in the lives of people globally. With our pipeline of vaccines, biologics, small molecules, and newer modalities, we are at the forefront of research to advance the prevention and treatment of diseases such as cancer, cardiometabolic diseases, Alzheimer's disease and infectious diseases including HIV, COVID-19, and Ebola. The Nonclinical Drug Safety group is seeking a highly motivated individual with strong technical skills and attention to detail to join the Toxicology Operations group. The Operations group performs in vivo nonclinical safety studies that range in duration from acute (single dose) to chronic (multiple dose up to 2 years) to support drug development. These studies are conducted in accordance with Good Laboratory Practices (GLP) and Organization for Economic Cooperation and Development (OECD) regulations. **NOTE: This position is for a 5-day work week, Monday through Friday, and includes additional coverage of weekends and holidays on a rotational basis.** **Primary Responsibilities** : + Perform assigned tasks that include dose administration via various routes to rodents and nonrodents; recording of body weights, food consumption, clinical observations; blood collection via various methods; obtaining electrocardiogram readings on non-rodents + Follow well-established Standard Operating Procedures and Good Laboratory Practices + Apply sound basic laboratory skills that include observing, recording, and assessing data + Maintain accurate and highly detailed laboratory records and documentation + Contribute to well-defined, complex research projects **Other responsibilities may include** : + Train and work cross-functionally in other areas within Nonclinical Drug Safety and Preclinical Development **Qualifications:** **Education** : + Bachelor's or Master's in Animal Sciences, Biology or a related discipline and relevant laboratory experience **Required Experience and Skills** : + A minimum of two (2) years of laboratory experience (through academic coursework, internship, or Academic/Industry position) + Act with impeccable integrity and adhere to the highest standards of trustworthy and ethical behavior in all interactions + Demonstrate effective written/oral communication skills + Must be willing to handle laboratory animals + Familiarity with recording and assessing laboratory data + Detail-oriented and able to work independently and in groups + Familiarity with Microsoft Office (predominantly Word and Excel) **Preferred Experience and Skills** : + Some experience in the pharmaceutical industry or biotech or similar + Regulatory awareness including Good Laboratory Practices, experience with electronic data capture for nonclinical studies and a basic knowledge of the drug development process \#EligibleforERP **Required Skills:** Animal Handling, Animal Science, Biology, Drug Development, Electronic Databases, In Vivo Studies, Laboratory Techniques, Physiology, Toxicity Studies, Toxicology **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". The salary range for this role is $87,300.00 - $137,400.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ****************************************************** . You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** No relocation **VISA Sponsorship:** No **Travel Requirements:** No Travel Required **Flexible Work Arrangements:** Not Applicable **Shift:** 1st - Day **Valid Driving License:** No **Hazardous Material(s):** N/A **Job Posting End Date:** 01/15/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R380428

Our company is a leading global biopharmaceutical company with a 125-year history of an inspiring mission to make discoveries that positively impact global healthcare. Our success is driven by putting patients first, operating with the highest integrity, and committing fully to our vision to make a difference in the lives of people globally. With our pipeline of vaccines, biologics, small molecules, and newer modalities, we are at the forefront of research to advance the prevention and treatment of diseases such as cancer, cardiometabolic diseases, Alzheimer's disease and infectious diseases including HIV, COVID-19, and Ebola. The Nonclinical Drug Safety group is seeking a highly motivated individual with strong technical skills and attention to detail to join the Toxicology Operations group. The Operations group performs in vivo nonclinical safety studies that range in duration from acute (single dose) to chronic (multiple dose up to 2 years) to support drug development. These studies are conducted in accordance with Good Laboratory Practices (GLP) and Organization for Economic Cooperation and Development (OECD) regulations. NOTE: This position is for a 5-day work week, Monday through Friday, and includes additional coverage of weekends and holidays on a rotational basis. Primary Responsibilities: Perform assigned tasks that include dose administration via various routes to rodents and nonrodents; recording of body weights, food consumption, clinical observations; blood collection via various methods; obtaining electrocardiogram readings on non-rodents Follow well-established Standard Operating Procedures and Good Laboratory Practices Apply sound basic laboratory skills that include observing, recording, and assessing data Maintain accurate and highly detailed laboratory records and documentation Contribute to well-defined, complex research projects Other responsibilities may include: Train and work cross-functionally in other areas within Nonclinical Drug Safety and Preclinical Development Qualifications: Education: Bachelor's or Master's in Animal Sciences, Biology or a related discipline and relevant laboratory experience Required Experience and Skills: A minimum of two (2) years of laboratory experience (through academic coursework, internship, or Academic/Industry position) Act with impeccable integrity and adhere to the highest standards of trustworthy and ethical behavior in all interactions Demonstrate effective written/oral communication skills Must be willing to handle laboratory animals Familiarity with recording and assessing laboratory data Detail-oriented and able to work independently and in groups Familiarity with Microsoft Office (predominantly Word and Excel) Preferred Experience and Skills: Some experience in the pharmaceutical industry or biotech or similar Regulatory awareness including Good Laboratory Practices, experience with electronic data capture for nonclinical studies and a basic knowledge of the drug development process #EligibleforERP Required Skills: Animal Handling, Animal Science, Biology, Drug Development, Electronic Databases, In Vivo Studies, Laboratory Techniques, Physiology, Toxicity Studies, Toxicology Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”. The salary range for this role is $87,300.00 - $137,400.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ******************************************************* You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: No relocation VISA Sponsorship: No Travel Requirements: No Travel Required Flexible Work Arrangements: Not Applicable Shift: 1st - Day Valid Driving License: No Hazardous Material(s): N/A Job Posting End Date: 01/15/2026 *A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Be a part of the legacy: Postdoctoral Research Fellow Program Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function at research laboratories is seeking a highly motivated postdoctoral fellow with expertise in machine learning to help transform drug discovery and preclinical development. You will join an interdisciplinary team and collaborate closely with research partners across our global organization. You will invent, prototype, and apply advanced Machine Learning (ML) methods-particularly in generative modeling and related areas-to expand our capabilities in designing, prioritizing, and characterizing novel therapeutic candidates. Primary Responsibilities + Conduct original research to develop state-of-the-art AI/Machine learning methods for drug discovery (e.g., molecular generative models, multi-objective optimization, property prediction, active learning, document authoring, document generation, hybrid AI system, multi-agent system) + Design and execute experiments, analyze results rigorously, and iterate rapidly on model architectures and training strategies + Build robust, reproducible code and workflows; contribute to shared libraries and documentation + Collaborate with chemists, biologists, Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) scientists, and data/ML engineers to translate methods into impactful applications + Communicate findings through internal presentations and peer-reviewed publications; present at conferences and workshops **Education Minimum Requirements** + Ph.D. (or completion within six months) in Computer Science, Statistics, Physics, Applied Mathematics, Bioinformatics, Computational Biology, Chem/Informatics, Engineering, or a related field **Required Experience and Skills** + Demonstrated research excellence and problem-solving ability; strong motivation to learn, innovate, and deliver + Proficiency in core ML/statistics topics such as probability, statistical inference, optimization, discrete math/algorithms, and/or probabilistic modeling + Strong programming skills in Python and experience with modern ML frameworks (e.g., PyTorch, TensorFlow) + Track record of publications and/or presentations in ML, computational chemistry/biology, or related fields + Excellent collaboration and communication skills; proven ability to work in cross-functional teams **Preferred Experience and Skills (nice to have)** + Experience with molecular representations (e.g., SMILES, graphs), generative models (e.g., diffusion models, VAEs, flow models), and sequence/structure models (e.g., transformers, GNNs, protein or RNA models) + Familiarity with cheminformatics/biophysics toolkits (e.g., RDKit), docking or molecular simulation, ADMET modeling, or DMPK-relevant endpoints + Practical experience with experimental design, active learning, uncertainty quantification, or multi-objective optimization + Software engineering best practices (Git, testing, containers), and experience working with large datasets and cloud/GPU environment postdoctoralopportunities **Required Skills:** Accountability, ADME, Clinical Study Management, Dosage Forms, Drug Metabolism, Ethical Compliance, Innovation, Machine Learning (ML), Modeling Simulations, Personal Initiative, Pharmaceutical Analysis, Pharmacodynamics, Pharmacognosy, Pharmacokinetic Modeling, Pharmacokinetics, Protocol Development, Regulatory Submissions, Scientific Writing **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". The salary range for this role is $70,500.00 - $110,900.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ****************************************************** . You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** Domestic **VISA Sponsorship:** Yes **Travel Requirements:** 10% **Flexible Work Arrangements:** Not Applicable **Shift:** Not Indicated **Valid Driving License:** No **Hazardous Material(s):** n/a **Job Posting End Date:** 01/19/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R378049

Be a part of the legacy: Postdoctoral Research Fellow Program Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function at research laboratories is seeking a highly motivated postdoctoral fellow with expertise in machine learning to help transform drug discovery and preclinical development. You will join an interdisciplinary team and collaborate closely with research partners across our global organization. You will invent, prototype, and apply advanced Machine Learning (ML) methods-particularly in generative modeling and related areas-to expand our capabilities in designing, prioritizing, and characterizing novel therapeutic candidates. Primary Responsibilities Conduct original research to develop state-of-the-art AI/Machine learning methods for drug discovery (e.g., molecular generative models, multi-objective optimization, property prediction, active learning, document authoring, document generation, hybrid AI system, multi-agent system) Design and execute experiments, analyze results rigorously, and iterate rapidly on model architectures and training strategies Build robust, reproducible code and workflows; contribute to shared libraries and documentation Collaborate with chemists, biologists, Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) scientists, and data/ML engineers to translate methods into impactful applications Communicate findings through internal presentations and peer-reviewed publications; present at conferences and workshops Education Minimum Requirements Ph.D. (or completion within six months) in Computer Science, Statistics, Physics, Applied Mathematics, Bioinformatics, Computational Biology, Chem/Informatics, Engineering, or a related field Required Experience and Skills Demonstrated research excellence and problem-solving ability; strong motivation to learn, innovate, and deliver Proficiency in core ML/statistics topics such as probability, statistical inference, optimization, discrete math/algorithms, and/or probabilistic modeling Strong programming skills in Python and experience with modern ML frameworks (e.g., PyTorch, TensorFlow) Track record of publications and/or presentations in ML, computational chemistry/biology, or related fields Excellent collaboration and communication skills; proven ability to work in cross-functional teams Preferred Experience and Skills (nice to have) Experience with molecular representations (e.g., SMILES, graphs), generative models (e.g., diffusion models, VAEs, flow models), and sequence/structure models (e.g., transformers, GNNs, protein or RNA models) Familiarity with cheminformatics/biophysics toolkits (e.g., RDKit), docking or molecular simulation, ADMET modeling, or DMPK-relevant endpoints Practical experience with experimental design, active learning, uncertainty quantification, or multi-objective optimization Software engineering best practices (Git, testing, containers), and experience working with large datasets and cloud/GPU environment postdoctoralopportunities Required Skills: Accountability, ADME, Clinical Study Management, Dosage Forms, Drug Metabolism, Ethical Compliance, Innovation, Machine Learning (ML), Modeling Simulations, Personal Initiative, Pharmaceutical Analysis, Pharmacodynamics, Pharmacognosy, Pharmacokinetic Modeling, Pharmacokinetics, Protocol Development, Regulatory Submissions, Scientific Writing Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”. The salary range for this role is $70,500.00 - $110,900.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ******************************************************* You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: Domestic VISA Sponsorship: Yes Travel Requirements: 10% Flexible Work Arrangements: Not Applicable Shift: Not Indicated Valid Driving License: No Hazardous Material(s): n/a Job Posting End Date: 01/17/2026 *A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Be a part of the legacy: Postdoctoral Research Fellow Program Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) function at research laboratories is seeking a highly motivated postdoctoral fellow with expertise in machine learning to help transform drug discovery and preclinical development. You will join an interdisciplinary team and collaborate closely with research partners across our global organization. You will invent, prototype, and apply advanced Machine Learning (ML) methods-particularly in generative modeling and related areas-to expand our capabilities in designing, prioritizing, and characterizing novel therapeutic candidates. Primary Responsibilities + Conduct original research to develop state-of-the-art AI/Machine learning methods for drug discovery (e.g., molecular generative models, multi-objective optimization, property prediction, active learning, document authoring, document generation, hybrid AI system, multi-agent system) + Design and execute experiments, analyze results rigorously, and iterate rapidly on model architectures and training strategies + Build robust, reproducible code and workflows; contribute to shared libraries and documentation + Collaborate with chemists, biologists, Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) scientists, and data/ML engineers to translate methods into impactful applications + Communicate findings through internal presentations and peer-reviewed publications; present at conferences and workshops **Education Minimum Requirements** + Ph.D. (or completion within six months) in Computer Science, Statistics, Physics, Applied Mathematics, Bioinformatics, Computational Biology, Chem/Informatics, Engineering, or a related field **Required Experience and Skills** + Demonstrated research excellence and problem-solving ability; strong motivation to learn, innovate, and deliver + Proficiency in core ML/statistics topics such as probability, statistical inference, optimization, discrete math/algorithms, and/or probabilistic modeling + Strong programming skills in Python and experience with modern ML frameworks (e.g., PyTorch, TensorFlow) + Track record of publications and/or presentations in ML, computational chemistry/biology, or related fields + Excellent collaboration and communication skills; proven ability to work in cross-functional teams **Preferred Experience and Skills (nice to have)** + Experience with molecular representations (e.g., SMILES, graphs), generative models (e.g., diffusion models, VAEs, flow models), and sequence/structure models (e.g., transformers, GNNs, protein or RNA models) + Familiarity with cheminformatics/biophysics toolkits (e.g., RDKit), docking or molecular simulation, ADMET modeling, or DMPK-relevant endpoints + Practical experience with experimental design, active learning, uncertainty quantification, or multi-objective optimization + Software engineering best practices (Git, testing, containers), and experience working with large datasets and cloud/GPU environment postdoctoralopportunities **Required Skills:** Accountability, ADME, Clinical Study Management, Dosage Forms, Drug Metabolism, Ethical Compliance, Innovation, Machine Learning (ML), Modeling Simulations, Personal Initiative, Pharmaceutical Analysis, Pharmacodynamics, Pharmacognosy, Pharmacokinetic Modeling, Pharmacokinetics, Protocol Development, Regulatory Submissions, Scientific Writing **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". The salary range for this role is $70,500.00 - $110,900.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ****************************************************** . You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** Domestic **VISA Sponsorship:** Yes **Travel Requirements:** 10% **Flexible Work Arrangements:** Not Applicable **Shift:** Not Indicated **Valid Driving License:** No **Hazardous Material(s):** n/a **Job Posting End Date:** 01/19/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R378049

We are seeking a highly motivated and skilled associate scientist to support analytical assay development, physicochemical characterization, and testing of therapeutic monoclonal antibodies. This hands-on role will be involved in conduct of experiments involving a variety of protein characterization techniques, and proficiency in operating and maintaining analytical instrumentation. The position is critical to the success of our therapeutic monoclonal antibody development programs. **Key Responsibilities:** + Perform analytical assays for the physicochemical characterization of monoclonal antibodies + Provide analytical testing support to cross-functional teams, including process development, cell line development, stability studies, and product characterization. + Perform routine laboratory work and ensure proper maintenance and calibration of analytical equipment. + Document experimental procedures, results, and conclusions in laboratory notebooks and technical reports. + Present findings and progress updates to project teams and stakeholders. **Qualifications:** **Minimum Education:** + Bachelor's degree in Biochemistry, Chemistry, Biotechnology, Bioengineering, or a related discipline. **Required Experience and Skills:** + Minimum of 1 year of experience working in a laboratory environment. + Hands-on experience with analytical instrumentation used of characterization of proteins such as HPLC, spectrometer and capillary electrophoresis system + Good understanding of the principles and mechanisms of commonly used analytical techniques + Proficiency in laboratory software and data analysis tools relevant to downstream operations. + Good organizational skills and the ability to handle large volumes of data. + Excellent analytical and problem-solving skills. + Strong communication and collaboration abilities. **Preferred Experience and Skills:** + Industry experience in the analytical assay development for biological therapeutics + Hands on experience in conducting analytical assays for therapeutic monoclonal antibody discovery or development + Knowledge and experience with different type of HPLC/UPLC based analytical assays + Knowledge in developability assessment and candidate selection of monoclonal antibody or biologics **Required Skills:** Accountability, Accountability, Analytical Instrumentation, Animal Science, Antibody Therapeutics, Assay Development, Biochemistry, Biodesign, Biological Sciences, Biophysics, Biotechnology, Capillary Electrophoresis (CE), Cell Biology, Cell Culture Techniques, Data Analysis, Immunochemistry, Innovation, Laboratory Documentation, Laboratory Techniques, Machine Learning (ML), Microbiology, Molecular Biology, Monoclonal Antibodies, Pipetting, Polyclonal Antibody Production {+ 3 more} **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". The salary range for this role is $70,500.00 - $110,900.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ****************************************************** . You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** No relocation **VISA Sponsorship:** No **Travel Requirements:** 10% **Flexible Work Arrangements:** Not Applicable **Shift:** 1st - Day **Valid Driving License:** No **Hazardous Material(s):** n/a **Job Posting End Date:** 01/21/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R379270

The Cell Pharmacology group in Department of Quantitative Biosciences is seeking a highly motivated Scientist with a background in immunology and oncology assays to join our Company's Research Laboratories in Boston. The primary responsibilities of the successful candidate will be to develop and characterize novel in vitro and ex vivo translational pharmacology assays to support autoimmune and cancer projects. These new assays will capture features of human biology to improve preclinical translation to the clinical efficacy. Responsibilities: Maintenance and propagation of cell lines, primary cell isolation and culture Develop screening assays to support therapeutic programs independently or in collaboration with senior scientists in the lab, execute assays at medium to high throughput, interpret and analyze the results of experiments, and successfully transfer assays onto automation platforms as needed. Interpret data and communicate results to stakeholders and management in timely manner. Meet project milestones and timelines. Conduct studies for biomarker identification and mechanism of action studies as needed to understand pharmacology. Implement novel technologies and approaches to solve program objectives and issues. Document protocols and results, comply with all laboratory safety and environmental requirements. Take on increasing responsibility within the Quantitative Biosciences group and on project teams as your skills develop. Collaborate across our global Quantitative Biosciences and other partner networks to develop capabilities, advance therapeutic programs and grow our scientific capital. Experience: Proficiency in cell culture, passaging and harvesting. Basic knowledge of lab automation and plate readers with an ability to propose new approaches and experimental designs as needed. Experience with medium to high throughput assay-related data analysis and an appreciation for the related quantitative and statistical concepts. Candidate should be a strong team player working across the organization with ability to adapt for changing priorities. Excellent oral and written communication skills. Passion for innovation and problem solving. Education Requirements: A master's in a relevant field (e.g. Biochemistry, Biology, Biotechnology, Molecular and Cell Biology, Pharmacology; Pharmaceutical Sciences) with hands-on experience implementing and interpreting immunoassays involving blood and primary cell culture, flow cytometry, qPCR, ELISA, and major platforms such as Meso Scale Discovery and Alphalisa OR a bachelor's degree with 3+ years of hands-on relevant laboratory experience. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts #EligibleforERP Required Skills: Accountability, Adaptability, Assay Development, Biochemistry, Biomarker Identification, Biotechnology, Cell-Based Assays, Cell Biology, Cell Cultures, Cell Culture Techniques, Cell Transfection, Cytometry, Data Analysis, Detail-Oriented, Enzyme Linked Immunosorbent Assay (ELISA), Flow Cytometry, Innovation, In Vitro Assays, Laboratory Safety, Luminex Assays, Mammalian Cell Culture, Molecular Biology Techniques, Pharmacology, Primary Cell Culture Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”. The salary range for this role is $96,100.00 - $151,200.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ******************************************************* You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: Domestic VISA Sponsorship: Yes Travel Requirements: No Travel Required Flexible Work Arrangements: Not Applicable Shift: Not Indicated Valid Driving License: No Hazardous Material(s): n/a Job Posting End Date: 01/19/2026 *A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

**Associate Principal Scientist, Analytical Commercialization Technology** The Analytical Commercialization Technology (ACT) group within Analytical Chemistry in Development and Supply (ACDS) is seeking applicants for an Associate Principal Scientist position available at the Rahway, NJ and West Point, PA sites. The successful candidate will utilize innovative analytical characterization technologies to drive late-stage pharmaceutical drug product development and commercialization. The Associate Principal Scientist responsibilities include, but not limited to, analytical method development and validation, drug product testing and analytical investigations in a cGMP environment, drug product and manufacturing process characterization, drug product stability studies, specification development, manufacturing process scale-up and validation support, preparation of Chemistry, Manufacturing, and Controls (CMC) documents for global regulatory submissions, and responses to regulatory questions. The successful candidate must be able to collaborate in a dynamic, integrated, and multidisciplinary team environment. The ideal candidate will have knowledge and proficiency in the following areas: separation techniques and aerosol science. Prior experience with inhalation product development and characterization is highly desired. Applicants must have effective organizational skills, multi-tasking, oral and written communications skills. **Education Minimum Requirements:** PhD in Analytical Chemistry or related discipline with 4+ years of relevant pharmaceutical development experience or MS in Analytical Chemistry or related discipline with 10+ years of relevant pharmaceutical development experience. **Required Experience and Skills:** + Strong background and extensive hands-on experience with common analytical techniques such as Ultrahigh/High Performance Liquid Chromatography (UHPLC/HPLC), Gas Chromatography, Ultraviolet (UV) and Infrared (IR) spectroscopy, Karl Fischer titration, and dissolution + Experience with inhalation product characterization including aerodynamic particle size distribution (APSD), delivered dose uniformity (DDU), metered dose uniformity (MDU) and particle size distribution (PSD) + Strong chemistry knowledge + Demonstrated problem solving ability + Excellent verbal and written communication skills, demonstrated creativity, and strong interpersonal skills + Ability to work in a team environment with cross-functional interactions **Preferred Experience and Skills:** + Experience with hyphenated analytical techniques such as LC/MS and GC/MS with proven ability in troubleshooting these methodologies + Experience with method development and validation + Familiarity with authoring relevant CMC sections of regulatory submissions **Required Skills:** Analytical Chemistry, Analytical Development, Chemical Biology, Chemical Processing, Chemical Synthesis, Chromatography, Computational Chemistry, Data Analysis, Enzymology, Experimental Development, Gas Chromatography Analysis, Gas Chromatography-Mass Spectrometry (GC-MS), High-Performance Liquid Chromatography (HPLC), Infrared Spectroscopy, Karl Fischer Titrations, Machine Learning (ML), Molecular Structure, Pharmaceutical Development, Spectrophotometry, Synthetic Chemistry **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". The salary range for this role is $142,400.00 - $224,100.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ****************************************************** . You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** Domestic **VISA Sponsorship:** Yes **Travel Requirements:** 10% **Flexible Work Arrangements:** Not Applicable **Shift:** 1st - Day **Valid Driving License:** No **Hazardous Material(s):** n/a **Job Posting End Date:** 01/23/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R380190

We are on a quest for cures and are committed to be the world's premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines. We are seeking an exceptional and experienced scientist in the role of Associate Principal Scientist in the South San Francisco Discovery Biologics group. The qualified candidate will be a scientist with a breadth and depth of expertise in immunization-based antibody discovery, including but not limited to expertise in adaptive immunity and B-cell biology, immunogen design, and experience with multiple hit finding platforms (e.g. high throughput microfluidics & NGS), in order to improve existing antibody discovery processes to help meet the needs for challenging targets and aggressive timelines. They will work closely with other team members and groups throughout the organization to help manage, perform, and troubleshoot antibody discovery programs. We recognize that the diversity in our team is our strength, and we are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of researchers to drive our core mission. What you will do: Propose and lead technology development initiatives to further optimize existing in vivo de novo platforms to increase hits and decrease timelines Serve as the antibody discovery representative on project teams to help define Target Candidate Profiles (TCP) and lead de novo hit finding strategies and campaigns Potential for future development opportunities to lead Biologics discovery projects in collaboration with therapeutic area scientists Stay abreast of external advancements in the relevant scientific fields Promote the external reputation of our company's Discovery Biologics department What you will need to be successful in this role: Qualifications & Experience Ph.D. with 4+ years or Master's with 8+ years relevant industry experience Experience in antibody drug discovery supporting therapeutic programs Excellent communication and collaboration skills Ability to manage multiple projects simultaneously Required skills: Depth of knowledge in adaptive immunity and B-cell biology and direct application towards optimizing antibody drug discovery and development campaigns Track record of driving scientific and platform innovations Experience leading therapeutic antibody discovery campaigns Strong hands-on laboratory skills, including but not limited to cell culture, molecular biology, assay development, and flow cytometry Established external reputation through publications, presentations, and/or scientific community engagement Preferred skills: Ideal candidate will have experience in protein therapeutics beyond traditional mAbs including alternative non-Ig scaffolds, bi- or multi-specifics, fusion proteins, and ADCs Required Skills: Antibody Discovery, Drug Discovery Process, High-Throughput Screening, Innovation, Machine Learning (ML), Microfluidics, Molecular Biology Techniques, Project Coordination, Team Strategy, Therapeutic Antibodies, Therapeutic Proteins Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”. The salary range for this role is $156,500.00 - $246,300.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ******************************************************* You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: Domestic VISA Sponsorship: Yes Travel Requirements: 10% Flexible Work Arrangements: Not Applicable Shift: Not Indicated Valid Driving License: No Hazardous Material(s): yes Job Posting End Date: 01/31/2026 *A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Associate Scientist Job Description: Our company's Pharmaceutical Sciences organization translates molecules to medicines, working from the discovery interface through registration stability manufacturing by designing, developing and scaling-up the formulation, device, and manufacturing process. Driving drug product design from the bench top to the Good Manufacturing Practice (GMP) manufacturing facilities, our Scientists use cutting edge science to transform drug delivery and manufacturing technology to positively impact patients. The successful candidate will be a passionate Scientist with strong academic fundamentals and a drive to develop new medicines to improve human health. In this role, the individual will be responsible for supporting the formulation development of new chemical entities as part of a matrix team from initial first in human formulations (suspensions, solutions, capsules, tablets) through final market formulation definition and manufacturing process robustness assessment. **Additional responsibilities are as follows:** + Develops and applies basic principles and scientific concepts to execute work in a laboratory or pilot plant environment to advance new solid oral drug products. + Capability to support manufacturing operations in non-GMP and GMP environments. + Executes routine experiments and data interpretation with appropriate technical guidance. + Ability to operate and trouble shoot equipment and processes. + Capable of learning practical laboratory/pilot plant skills and fundamental scientific principles to utilize as part of their daily responsibilities. + Can understand overall project timelines to manage prioritization of individual contributor deliverables with appropriate supervision. + Works well with others in collaborative team environments. + Builds awareness of relevant new and current technologies to grow as a pharmaceutical scientist. **Education Minimum Requirement:** + B.S. or M.S. degree in Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences or related discipline (expected no later than June 2026). **Required Experience and Skills:** + Ability to learn and apply new scientific principles to execution of daily responsibilities + Demonstrated ability to collate and conduct basic data analysis + Prior experience with Microsoft Office + Strong verbal and written communication skills **Preferred Experience and Skills:** + Prior experience in a laboratory environment + Prior experience with statistical software (JMP, Minitab) and numerical analysis software (Matlab) + Strong mechanical aptitude + Passion to learn and develop as a pharmaceutical scientist \#eligibleforerp PSCS **Required Skills:** Accountability, Accountability, Analytical Thinking, Animal Vaccination, Biochemical Analysis, Biomedical Engineering, Chemical Engineering, Clinical Manufacturing, Creativity, Data Analysis, Dosage Forms, Econometric Software, Evaluating New Technologies, GMP Compliance, Machine Learning (ML), Manufacturing Operations, Manufacturing Support, Medical Knowledge, Microsoft Office, Patent Analysis, Pharmaceutical Production, Pharmaceutical Sciences, Pharmacology, Product Development, Scientific Methods {+ 5 more} **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". The salary range for this role is $70,500.00 - $110,900.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ****************************************************** . You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** Domestic **VISA Sponsorship:** Yes **Travel Requirements:** 10% **Flexible Work Arrangements:** Not Applicable **Shift:** 1st - Day **Valid Driving License:** No **Hazardous Material(s):** No **Job Posting End Date:** 01/16/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R378813

The Chemical Commercialization Technology (CCT) department, which is part of our company Manufacturing Division is seeking a self-motivated individual who is looking for an opportunity to work in a highly collaborative environment that provides substantial technical responsibility and leadership of internal and external work. The Associate Principal Scientist, Engineering position leverages scientific/technical experience to develop safe and robust manufacturing processes through process characterization, technology transfer, validation, filing and supply support of late-stage projects in the small molecule pipeline. The candidate will provide scientific expertise by learning and utilizing Quality Risk Management methodologies and tools for statistical design of experiments. This role involves hands-on experimentation at the laboratory bench and kilo lab scales in addition to technology transfer to commercial manufacturing facilities. Mentoring is required to develop junior staff to initiate, plan and execute characterization and complete technical support objectives. The scientist will be expected to exhibit a mindset of safety and quality compliance, which will include following current Good Manufacturing Practices (cGMPs), and participating in risk assessments, deviation investigations, and Good Documentation Practices (GDPs). Position Qualifications: Education Minimum Requirement: The position requires a BS and/or MS in Chemical Engineering or a related field from an accredited college/university plus at least 8 years of relevant work experience in process development or PhD with at least 4 years of relevant work experience post PhD defense. Required Experience and Skills: Relevant work experience in chemical process development, including the following: Demonstrated capability to develop and execute an experimental program to address issues of process design, robustness and productivity Experience with process scale-up and technology transfer, moving from laboratory to pilot plant or factory Ability to mentor technical staff in the laboratory and through data analysis Highly effective communication and collaboration skills Good organizational, interpersonal, writing, and time management skills Ability to operate within a cross-functional process development team Preferred Experience and Skills: Experience performing lab-based research/process development including performing unit operations common in small molecule drug substance process development such as chemical reactions, work-up, and crystallization Experience leading regulatory file authoring, validation planning and execution Experience guiding internal/external technical discussions Familiarity with statistical design and analysis tools Familiarity with concepts and application of current Good Manufacturing Practices (cGMPs) ideally during pharmaceutical drug substance / drug product development and production, e.g. in a pilot and/or factory setting Experience with mathematical modeling, theoretical scaling calculations, and Quality by Design principles. Required Skills: Bioprocessing, Chemical Engineering, Chemical Technology, Data Analysis, Detail-Oriented, Maintenance Supervision, Manufacturing Process Validation, Manufacturing Quality Control, Manufacturing Scale-Up, Protein Purifications, Regulatory Submissions, Technical Writing Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”. The salary range for this role is $142,400.00 - $224,100.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ******************************************************* You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: Domestic VISA Sponsorship: Yes Travel Requirements: 10% Flexible Work Arrangements: Not Applicable Shift: 1st - Day Valid Driving License: No Hazardous Material(s): n/a Job Posting End Date: 01/20/2026 *A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

In BARDS (Biostatistics and Research Decision Sciences), a distinguished department within our renowned Research and Development division, quantitative scientists, in partnership with other subject matter experts, apply state-of-the art scientific methodologies and tools to enable the discovery, development, regulatory approval, manufacturing, and marketing of medical drugs and vaccines for the benefit of patients and global human health. This position supports statistical programming activities for multiple and/or late stage drug/vaccine clinical development projects. Accountability predominantly includes the development and execution of statistical analysis and reporting deliverables (e.g. safety and efficacy analysis datasets, tables, listings, figures), the span of which range from individual clinical trials to world-wide regulatory application submissions and post marketing support. The incumbent is responsible for the design and maintenance of statistical datasets that support multiple stakeholder groups which include clinical development, outcomes research and safety evaluation. The position is a key collaborator with statistics and other project stakeholders in ensuring that project plans are executed efficiently with timely and high quality deliverables. For assigned projects the position serves as the statistical programming point of contact and knowledge holder through the entire product lifecycle. **Primary Activities** **:** + Effective analysis and report programming development and validation utilizing global and TA standards and following departmental SOPs and good programming practices. + Maintain and manage a project plan including resource forecasting. + Coordinate the activities of a global programming team that includes outsource provider staff. + Membership on departmental strategic initiative teams **Education and Minimum Requirement** **:** + BA/BS in Computer Science, Statistics, Applied Mathematics, Life Sciences, Engineering or related field plus 9 years SAS programming experience in a clinical trial environment. + MS in Computer Science, Statistics, Applied Mathematics, Life Sciences, Engineering or related field plus 7 or more years SAS programming experience in a clinical trial environment. **Department Required Skills and Experience:** + Excellent interpersonal skills and ability to negotiate and collaborate effectively. + Excellent written, oral, and presentation skills + Broad knowledge and significant experience in developing analysis and reporting deliverables for R&D projects (data, analyses, tables, graphics, listings) + Strong project management skills; leadership at a program level; determines approach and ensures consistency and directs development of others when opportunities arise; ability to engage key stakeholders. **Position Specific Required Skills and Experience:** + Significant expertise in SAS and clinical trial programming including data steps, procedures, SAS/MACRO, SAS/GRAPH; systems and database expertise. + Experience leading large and/or complex statistical programming projects that include coordinating the activities of a programming team. + US and/or worldwide drug or vaccine regulatory application submission experience at the leadership level including the development of electronic submission deliverables. + Designs and develops complex programming algorithms. + Ability to comprehend analysis plans which may describe methodology to be programmed, an understanding of statistical terminology and concepts. + Familiarity with clinical data management concepts + Experience in CDISC and ADaM standards + Demonstrated success in the assurance of deliverable quality and process compliance. + Strategic thinking - ability to turn strategy into tactical activities; design of statistical databases with the end in mind that optimize analysis and reporting and leverage departmental standards and industry best-practices. + Ability to anticipate stakeholder requirements. ****** **Preferred Skills and Experience:** + Strong working knowledge of reporting processes (SOPs) and software development life cycle (SDLC) + Experience providing technical and/or programming guidance and mentoring to colleagues. + Ability and interest to work across cultures and geographies. + Ability to complete statistical programming deliverables through the use of global outsource partner programming staff. + Experience developing and managing a project plan using Microsoft Project or similar package. + Active in professional societies + Experience in process improvement. \#eligiblefor ERP BARDS2020 SPJOBS VETJOBS \#EBRG **NOTICE** **FOR** **INTERNAL** **APPLICANTS** In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions. _As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal_ _Opportunity Employment laws, visit:_ _EEOC Know Your Rights_ _EEOC GINA Supplement _ _We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively._ _Learn more about your rights, including under California, Colorado and other US State Acts (************************************************************************************************************************************************************************************************** **Required Skills:** **Preferred Skills:** Algorithms, Algorithms, Applied Mathematics, Biostatistics, Business Process Improvements, Business Strategies, Clinical Development, Clinical Research, Clinical Testing, Clinical Trial Designs, Clinical Trials, Cost Management, Creativity, Data Management, Geography, Initiative Activity, Leadership, Lean Process Improvements, Life Science, Long Term Planning, Maintenance Strategy, Marketing, Microsoft Project, New Program Development, Oncology {+ 21 more} Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". The salary range for this role is $135,500.00 - $213,400.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ****************************************************** . You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** Domestic **VISA Sponsorship:** Yes **Travel Requirements:** No Travel Required **Flexible Work Arrangements:** Hybrid **Shift:** 1st - Day **Valid Driving License:** No **Hazardous Material(s):** n/a **Job Posting End Date:** 01/26/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R306311

Be a part of the legacy: Postdoctoral Research Fellow Program Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. The Epidemiology Department is seeking a passionate and motivated Postdoctoral Fellow to join the Epidemiology-Oncology team. The fellow will work with a highly collaborative and multidisciplinary team of experts in epidemiology, biostatistics, and bioinformatics to develop a framework comprised of standardized analytic approaches to efficiently generate robust and reproducible real-world evidence across different tumor types, patient populations, and molecular biomarkers. The fellow will conduct literature reviews, develop standardized analysis plans with input from key stakeholders, build and implement reproducible workflows, conduct analyses of different clinico-genomics databases, and lead training sessions to enable adoption of the framework across the department. Education Minimum Requirement: Candidate must hold a PhD, obtained within the last three years, or Ph.D. completed within 6 months of hire (e.g., PhD, DrPH, PharmD/MPH, MD/MPH, etc.) in epidemiology or public health, with a focus on cancer epidemiology and modeling. Required Experience and Skills: Broad knowledge and experience in epidemiologic research and observational study design Hands-on research experience using real-world data or other large-scale datasets (e.g., clinico-genomic databases, EHR, claims, registries) Strong quantitative skills with experience conducting statistical analyses in a clinical research setting Proficiency in statistical programming (SAS and/or R) Proven ability to complete research projects resulting in peer-reviewed scientific publications and conference presentations Strong organizational, problem solving, and troubleshooting skills Excellent written and verbal communication skills Ability to plan and execute independent research, manage multiple projects, and collaborate effectively across multidisciplinary teams Preferred Experience and Skills: Background in cancer epidemiology, molecular epidemiology, or genetic epidemiology Proficiency in other programming languages (e.g., Python) Understanding of oncology molecular biomarkers, including genomic analyses Experience with data standardization frameworks and common data models (e.g., OMOP) Responsibilities: Lead the design, testing, and implementation of a comprehensive data analytics framework to guide the process of managing, analyzing, reporting, and interpreting real-world biomarker data Take part in epidemiologic research projects using real-world clinico-genomics data Solicit input from key internal stakeholders through written and oral communication Communicate research findings to cross-functional teams and internal stakeholders through written reports and oral presentations Disseminate research findings externally via scientific conference presentations and publications in peer-reviewed scientific journals Demonstrate leadership through process ownership and the training of colleagues to implement the developed framework Maintain and enhance professional knowledge and skills working in an industry setting postdoctoralopportunities Required Skills: Accountability, Accountability, Adaptability, Analytical Chemistry, Bioinformatics, Biostatistics, Cell Culture Techniques, Clinical Research, Computational Biology, Data Analysis, Epidemiology, Immunoassays, In Vivo Mouse Models, Management Process, Mathematical Biology, Molecular Biology, Multidisciplinary Collaboration, Multi-Management, Observational Studies, Oncology, Parasitology, Programming Languages, Project Reviews, Public Health, Scientific Research {+ 4 more} Preferred Skills: Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”. San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: Domestic VISA Sponsorship: Yes Travel Requirements: 10% Flexible Work Arrangements: Hybrid Shift: Not Indicated Valid Driving License: No Hazardous Material(s): n/a Job Posting End Date: 01/17/2026 *A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

**Be a part of the legacy: Postdoctoral Research Fellow Program** Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. The Epidemiology Department is seeking a passionate and motivated Postdoctoral Fellow to join the Epidemiology-Oncology team. The fellow will work with a highly collaborative and multidisciplinary team of experts in epidemiology, biostatistics, and bioinformatics to develop a framework comprised of standardized analytic approaches to efficiently generate robust and reproducible real-world evidence across different tumor types, patient populations, and molecular biomarkers. The fellow will conduct literature reviews, develop standardized analysis plans with input from key stakeholders, build and implement reproducible workflows, conduct analyses of different clinico-genomics databases, and lead training sessions to enable adoption of the framework across the department. **Education Minimum Requirement:** + Candidate must hold a PhD, obtained within the last three years, or Ph.D. completed within 6 months of hire (e.g., PhD, DrPH, PharmD/MPH, MD/MPH, etc.) in epidemiology or public health, with a focus on cancer epidemiology and modeling. **Required Experience and Skills:** + Broad knowledge and experience in epidemiologic research and observational study design + Hands-on research experience using real-world data or other large-scale datasets (e.g., clinico-genomic databases, EHR, claims, registries) + Strong quantitative skills with experience conducting statistical analyses in a clinical research setting + Proficiency in statistical programming (SAS and/or R) + Proven ability to complete research projects resulting in peer-reviewed scientific publications and conference presentations + Strong organizational, problem solving, and troubleshooting skills + Excellent written and verbal communication skills + Ability to plan and execute independent research, manage multiple projects, and collaborate effectively across multidisciplinary teams **Preferred Experience and Skills:** + Background in cancer epidemiology, molecular epidemiology, or genetic epidemiology + Proficiency in other programming languages (e.g., Python) + Understanding of oncology molecular biomarkers, including genomic analyses + Experience with data standardization frameworks and common data models (e.g., OMOP) **Responsibilities:** + Lead the design, testing, and implementation of a comprehensive data analytics framework to guide the process of managing, analyzing, reporting, and interpreting real-world biomarker data + Take part in epidemiologic research projects using real-world clinico-genomics data + Solicit input from key internal stakeholders through written and oral communication + Communicate research findings to cross-functional teams and internal stakeholders through written reports and oral presentations + Disseminate research findings externally via scientific conference presentations and publications in peer-reviewed scientific journals + Demonstrate leadership through process ownership and the training of colleagues to implement the developed framework + Maintain and enhance professional knowledge and skills working in an industry setting postdoctoralopportunities **Required Skills:** Accountability, Accountability, Adaptability, Analytical Chemistry, Bioinformatics, Biostatistics, Cell Culture Techniques, Clinical Research, Computational Biology, Data Analysis, Epidemiology, Immunoassays, In Vivo Mouse Models, Management Process, Mathematical Biology, Molecular Biology, Multidisciplinary Collaboration, Multi-Management, Observational Studies, Oncology, Parasitology, Programming Languages, Project Reviews, Public Health, Scientific Research {+ 4 more} **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** Domestic **VISA Sponsorship:** Yes **Travel Requirements:** 10% **Flexible Work Arrangements:** Hybrid **Shift:** Not Indicated **Valid Driving License:** No **Hazardous Material(s):** n/a **Job Posting End Date:** 01/17/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R374275

**Be a part of the legacy: Postdoctoral Research Fellow Program** Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery. The Epidemiology Department is seeking a passionate and motivated Postdoctoral Fellow to join the Epidemiology-Oncology team. The fellow will work with a highly collaborative and multidisciplinary team of experts in epidemiology, biostatistics, and bioinformatics to develop a framework comprised of standardized analytic approaches to efficiently generate robust and reproducible real-world evidence across different tumor types, patient populations, and molecular biomarkers. The fellow will conduct literature reviews, develop standardized analysis plans with input from key stakeholders, build and implement reproducible workflows, conduct analyses of different clinico-genomics databases, and lead training sessions to enable adoption of the framework across the department. **Education Minimum Requirement:** + Candidate must hold a PhD, obtained within the last three years, or Ph.D. completed within 6 months of hire (e.g., PhD, DrPH, PharmD/MPH, MD/MPH, etc.) in epidemiology or public health, with a focus on cancer epidemiology and modeling. **Required Experience and Skills:** + Broad knowledge and experience in epidemiologic research and observational study design + Hands-on research experience using real-world data or other large-scale datasets (e.g., clinico-genomic databases, EHR, claims, registries) + Strong quantitative skills with experience conducting statistical analyses in a clinical research setting + Proficiency in statistical programming (SAS and/or R) + Proven ability to complete research projects resulting in peer-reviewed scientific publications and conference presentations + Strong organizational, problem solving, and troubleshooting skills + Excellent written and verbal communication skills + Ability to plan and execute independent research, manage multiple projects, and collaborate effectively across multidisciplinary teams **Preferred Experience and Skills:** + Background in cancer epidemiology, molecular epidemiology, or genetic epidemiology + Proficiency in other programming languages (e.g., Python) + Understanding of oncology molecular biomarkers, including genomic analyses + Experience with data standardization frameworks and common data models (e.g., OMOP) **Responsibilities:** + Lead the design, testing, and implementation of a comprehensive data analytics framework to guide the process of managing, analyzing, reporting, and interpreting real-world biomarker data + Take part in epidemiologic research projects using real-world clinico-genomics data + Solicit input from key internal stakeholders through written and oral communication + Communicate research findings to cross-functional teams and internal stakeholders through written reports and oral presentations + Disseminate research findings externally via scientific conference presentations and publications in peer-reviewed scientific journals + Demonstrate leadership through process ownership and the training of colleagues to implement the developed framework + Maintain and enhance professional knowledge and skills working in an industry setting postdoctoralopportunities **Required Skills:** Accountability, Accountability, Adaptability, Analytical Chemistry, Bioinformatics, Biostatistics, Cell Culture Techniques, Clinical Research, Computational Biology, Data Analysis, Epidemiology, Immunoassays, In Vivo Mouse Models, Management Process, Mathematical Biology, Molecular Biology, Multidisciplinary Collaboration, Multi-Management, Observational Studies, Oncology, Parasitology, Programming Languages, Project Reviews, Public Health, Scientific Research {+ 4 more} **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** Domestic **VISA Sponsorship:** Yes **Travel Requirements:** 10% **Flexible Work Arrangements:** Hybrid **Shift:** Not Indicated **Valid Driving License:** No **Hazardous Material(s):** n/a **Job Posting End Date:** 01/17/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R374275

We are seeking an energetic and highly motivated Scientist in Antibody Engineering with hands‑on experience in antibody discovery, optimization, and characterization. This individual will work as part of a rapidly growing bio-therapeutics group focusing on lead selection for new projects and development of leads from established discovery pipeline projects. The successful candidate will design and execute strategies to generate, engineer, and mature therapeutic antibodies and novel biologics. The successful candidate will collaborate cross‑functionally with Discovery Biology, Protein Sciences, Structural Biology, and Developability/CMC to advance molecules from hit identification through lead optimization. **Responsibilities:** + Design and initiate target-focused antibody discovery strategies + Design, develop and optimize selection methods to enrich for affinity, specificity, cross‑reactivity, and epitope diversity + Interface with CROs or platform vendors for immunization or display campaigns as needed + Conduct affinity maturation, speciation (e.g. caninization/felinization), and specificity engineering (e.g., CDR grafting, back‑mutation, structure‑guided design) + Engineer formats including Fabs, sc Fvs, VHHs, bispecifics, multispecifics, and Fc variants for tailored effector functions and half‑life + Apply in silico tools for sequence liability assessment, developability predictions, and structure modeling + Work with other team members to characterize biophysical and biochemical properties + Assess binding by ELISA, SPR/BLI, flow cytometry + Perform epitope binning/mapping and cross‑species reactivity + Collaborate with biology teams to evaluate potency, MOA, and functional readouts + Work with CMC teams to screen for developability (solubility, stability, aggregation, viscosity, PTM liabilities) and implement sequence fixes + Provide input on sequence selection and manufacturability risks + Plan, prioritize, and execute experiments; analyze data and present in cross‑functional forums + Author study reports and contribute to patent filings and regulatory documents + Mentor junior associates and help implement best practices and data management + Apply knowledge of key signal transduction pathways to design appropriate assay systems for characterization of biological and pharmacological effects of new veterinary therapeutics. + Develop and manage project specific milestones and timelines. + Manage the R&D relationships with external service providers. + Prepare progress reports and make presentations to stakeholders. + Stay informed of external advances & technologies to enhance the product development portfolio. + Communicate progress and plans to a variety of stakeholders with diverse expertise. + Provide support, coaching or assistance to other team members. **Education Minimum Requirement:** + Ph.D. in a biological discipline **Required Experience and Skills:** + 3+ years relevant work experience in antibody discovery/engineering + Demonstrated experience with at least one display platform (phage, yeast, or mammalian) or immunization‑based antibody discovery + Hands‑on expertise in antibody engineering (speciation, affinity maturation, specificity tuning, format engineering) + Proficiency in biomolecular interaction methods and analytical characterization (e.g., SPR/BLI) + Proficiency with developability assessment and mitigation of sequence liabilities (e.g., deamidation, isomerization, oxidation, glycosylation hotspots) + Strong data analysis and documentation skills + Proficiency with molecular biology and sequence design tools (e.g., Geneious, MOE/Rosetta, IgBLAST/IMGT) + Ability to interpret and analyze data from key biological, biochemical and immunological assay systems and design appropriate follow-on experiments + Ability to contribute or manage more than one project at a time. + Excellent communication and cross‑functional collaboration skills **Preferred Qualifications** + Experience with bispecific/multispecific formats + Experience with Fc engineering for effector function and half‑life + Experience with computational antibody design + Familiarity with early CMC and developability workflows + Experience managing CROs or external partners **Required Skills:** Accountability, Analytical Characterization, Antibody Engineering, Antibody Therapeutics, Assay, Bioanalytical Analysis, Bioanalytical Techniques, Biomarker Development, Cell-Based Assays, Clinical Judgment, Detail-Oriented, Ethical Compliance, Experimental Methods, Immunohistochemistry (IHC), In Vivo Pharmacology, Mass Spectrometry Analysis, Polyclonal Antibody Production, Product Development, Project Management, Protein Chemistry, Scientific Research, Scientific Writing **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". The salary range for this role is $126,500.00 - $199,100.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ****************************************************** . You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** Domestic **VISA Sponsorship:** Yes **Travel Requirements:** 10% **Flexible Work Arrangements:** Not Applicable **Shift:** Not Indicated **Valid Driving License:** No **Hazardous Material(s):** N/A **Job Posting End Date:** 01/19/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R379382

The 2-year Physician Scientist Program provides pharmaceutical medicine training and opportunities to physicians completing residency or fellowship with the goal of recruiting new talent and contributing to the organization's inclusion objectives. The program provides in-depth exposure to clinical drug development with emphasis on key elements of clinical trial planning, execution, data analysis and reporting of clinical trial results. Physician Scientists will develop skills working with clinical and cross-functional teams as clinical programs progress toward regulatory approvals. Successful candidates will spend their first year in one of the following areas: (a) **Global Clinical Development:** Understand the role and methods of pharmaceutical research, participate in the writing of research protocols, conduct of clinical trials, safety monitoring, analysis of data and communication of study findings; (b) **Global Regulatory Affairs and Clinical Safety:** Focus on late-stage and lifecycle drug activities, understand key regulatory policies and the procedures for interacting with health agencies (e.g. FDA); understand key elements in pharmacovigilance, drug safety monitoring, signal detection and processing of adverse reports; (c) **Global Medical/Scientific Affairs:** Exposure to the management of a product asset prior to, during and after the launch phase (US and Global) including caveats on drug promotion. After a successful first year, the Physician Scientist will be equipped to assume a leading role in the team with additional responsibilities and interactions. The Physician Scientist also has the opportunity to do a second 1-year rotation in another area instead. **Required Education and Experience: ** + Candidates must currently hold an MD degree and have completed residency or fellowship training in an accredited US medical program, preferably within the last 5 years. **Required Skills:** Clinical Development, Clinical Research, Clinical Sciences, Clinical Trial Planning, Clinical Trials, Clinical Trials Monitoring, Communication, Drug Development, Drug Research, Ethical Standards, Good Clinical Practice (GCP), Medical Research, Medical Writing, Pharmaceutical Research, Pharmacy Regulation, Protocol Development, Regulatory Policies, Research Proposals, Scientific Consulting, Scientific Research **Preferred Skills:** Current Employees apply HERE (***************************************************** Current Contingent Workers apply HERE (***************************************************** **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (*************************************** if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (****************************************************************************************** EEOC GINA Supplement We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (********************************************** **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote". The salary range for this role is $190,800.00 - $300,300.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at ****************************************************** . You can apply for this role through **************************** (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** **VISA Sponsorship:** **Travel Requirements:** **Flexible Work Arrangements:** Hybrid **Shift:** **Valid Driving License:** **Hazardous Material(s):** **Job Posting End Date:** 01/30/2026 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R380993

We are seeking a computational biologist with a strong track record of advancing biological discoveries through data analyses to join the Vertex Data and Computational Sciences (DCS) organization. In this role, you will leverage cutting‑edge computational biology to accelerate the development of transformative therapies for serious human diseases. As a member of cross-functional disease project teams, you will contribute to the development of novel therapies in areas including lung diseases and pain. You will design genomics and human genetic studies, develop and apply analytical methods, and interpret results that directly inform program strategy, target evaluation, and mechanistic understanding. You will also play a key role in innovating, evaluating, and applying state-of-the-art computational analyses to enable rapid, data-driven decisions. An independent and proactive approach, along with seamless cross-functional collaboration will be essential for success in this role. This is a San Diego based, hybrid position requiring 3 days/week onsite. Key responsibilities: Proactively collaborate with cross‑functional project teams as the computational biology expert to identify key scientific questions that can be addressed through human genetics, genomics, sequencing, and computational analyses. Design and execute studies across diverse omics, including bulk RNA‑seq, whole‑genome sequencing, single‑cell RNA‑seq, spatial transcriptomics, and human genetics. Perform sophisticated computational analyses of internal and external datasets, integrating deep critical thinking, statistical rigor, domain expertise, and best practices from the literature to generate actionable insights. Incorporate publicly available genomic resources (e.g., GTEx, gnom AD, FinnGen, UK Biobank) to contextualize and interpret internal data. Distill complex analyses and scientific results into clear presentations, including key take-home messages and recommendations for next steps to a broad audience. Author study reports, white papers, and manuscripts to support internal decision-making and external communications including regulatory filings. Partner with the DCS method development team to develop innovative methods and improve usability, accuracy, and robustness of existing ones. Knowledge and Skills: A proven track record in the analysis, visualization, and interpretation of genomic and next-generation sequencing (NGS) data Solid scientific understanding of gene editing, the role of genetic variation in human disease, molecular biology, and cellular biology Expertise with applying computational methods and bioinformatics tools to large-scale data Solid understanding of statistics Education and Experience: PhD degree (or Master's degree) in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field with 0-3 years (or 3+ years for Master's degree) of productive, relevant industry or post-doc experience. A proven track record of stand-out excellence in the analysis, visualization, and interpretation of genomic data (such as next-generation sequencing (NGS)) or human genetic data. Demonstrated ability to work across cross-functional teams, ensuring timely progress. Superior communication skills, demonstrating confidence and versatility in presenting verbally to diverse audiences and writing technical documents. Deep scientific understanding of genetic variation in human disease, molecular biology, and cellular biology. Expertise with rapidly applying computational methods and bioinformatics tools to large-scale data. Proficiency with R and/or python, and high-performance computing systems; solid understanding of statistics. A team-oriented growth mindset that welcomes feedback from others and supports other team members; a positive attitude that enthusiastically tackles and overcomes challenges. #LI-KM1 #LI-Hybrid Pay Range: $112,000 - $168,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group based in Boston's Seaport District. The Health Economics & Outcomes Research Associate Director will participate in the shaping and execution of HEOR strategies that optimize the value proposition for Vertex's Cystic Fibrosis and early pipeline assets through each stage of development, including launch and post-launch phases. This position reports to the Senior Director HEOR, CF and Early Pipeline. Key Duties and Responsibilities: Leads execution of complex HEOR evidence generation studies, including: prospective and retrospective observational studies, systematic literature reviews, cost-effective analyses and budget impact models, Indirect Treatment Comparisons, COA strategy, PRO measure development and validation, as needed, to support the asset value Effectively leads external research partners to ensure robust scientific methods are applied to study design and execution and in compliance with all local regulations; is accountable for study design, data analysis and the quality of the evidence produced. Excellent project management is a pre-requisite to ensure studies delivered on time and within budget. Collaborates with the medical communications teams on publication strategy and ensure that dissemination of HEOR evidence is timely and has maximum impact Partners and works closely with Global Pricing and Market Access to support development of product value proposition/value messaging and co-lead development of robust Global launch deliverables (e.g., global value dossier) Knowledge and Skills: Strong track record of publication in peer-reviewed journals Strong background in clinical outcome assessment (COA) measurement strategy; experience in PRO development/validation and qualitative research methodology Technical expertise in HEOR; able to formulate and lead creative research projects and ensure conduct is technically and scientifically rigorous and reflects best HEOR practices Strong verbal and written communications skills, including presentation skills to communicate difficult concepts and persuade others; comfortable communicating complex concepts and adapting presentation style to a variety of audiences Ability to apply knowledge of US healthcare system, global health technology appraisal requirements, and clinical development, to identify evidence gaps and formulate evidence generation strategies Understanding of the legal and regulatory environment of the pharmaceutical industry, with spotless history of compliance and ethical workplace conduct Education and Experience: Advanced degree (PhD, MD, Master's degree, MPH, or PharmD) in a relevant discipline. Typically requires 8 years of experience, with substantial background in HEOR, or the equivalent combination of education and experience Pay Range: $172,000 - $258,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com