Arrowhead Pharmaceuticals jobs

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position We're looking for a detail-oriented Help Desk Technician to provide front line support for our users across a hybrid Windows Active Directory and Microsoft Entra ID environment. You'll resolve incidents, fulfill service requests, and assist with endpoint configuration and compliance using Microsoft Intune. The ideal candidate is customer focused, calm under pressure, and comfortable troubleshooting across Windows, Microsoft 365, and basic networking. Responsibilities Provide Tier 1-2 support via phone, chat, email, and remote tools; document all work in the ticketing system and meet SLAs. Troubleshoot Windows 11 issues (login, profiles, performance, application errors, updates). Support Microsoft 365 Office suite and basic Exchange Online tasks (mailbox access, distribution lists, shared mailboxes). Assist with account lifecycle in Windows Active Directory (user creation, group membership) and Microsoft Entra ID (cloud accounts, app assignments). Enroll and manage devices using Intune (Windows, iOS/iPadOS, Android): configuration profiles, compliance policies, and feature updates. Assist with OS image creation and deployment, application packaging and installation (Win32/MSIX), and troubleshoot install/update failures. Diagnose and resolve issues with laptops/desktops, docking stations, monitors, webcams, headsets, printers/MFDs. Coordinate warranty/repair, RMA, and hardware inventory updates. Basic troubleshooting of network connectivity (DNS, DHCP, Wi Fi) and remote access clients. Create/update knowledge base articles, quick start guides, and runbooks. Identify recurring issues, propose fixes, and escalate appropriately. Requirements: Technical degree in an information technology related field 1 years in a help desk or desktop support role in a Windows enterprise environment. Hands on experience with Active Directory and Microsoft Entra ID for identity and access tasks. Practical knowledge of Microsoft Intune for device enrollment, policy management, app deployment, and compliance. Proficiency with Windows 11, Microsoft 365 apps, and common endpoint drivers/peripherals. Familiarity with PowerShell for routine administrative tasks (e.g., querying AD users/groups, basic Intune/Graph scripts). Solid grasp of TCP/IP fundamentals, DNS, DHCP, and Wi Fi troubleshooting. Strong communication skills; ability to explain technical topics to non-technical users. Preferred: Bachelor's degree in Computer Science or a related field CompTIA A+, Network+, or Microsoft Certified: MD 102 (Endpoint Administrator) Scripting beyond fundamentals (PowerShell modules like Az, MSGraph, Intune). Exposure to Exchange Online, Teams telephony, Bitlocker and OneDrive sync conflict resolution. Knowledge of Entra ID Connect / Cloud Sync concepts and hybrid identity basics. Familiarity with MacOS basics and mobile device management (iOS/Android) within Intune. #LI-ONSITE Wisconsin pay range $55,000-$67,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Senior Medical Writer will collaborate with lead medical writers and cross-functional team members to provide authoring support to numerous regulatory documents. The Senior Medical Writer will also lead key supportive documents. The Senior Medical Writer will author with accuracy and technical competency to ensure delivery of high quality regulatory clinical documents in a timely manner. The Senior Medical Writer will demonstrate a high level of flexibility, collaboration skills, and eagerness to learn. Responsibilities Contributing author to regulatory documents such as, but not limited to, clinical study protocols and protocol amendments, investigator's brochures (IBs), clinical study reports (CSRs), components of NDA/MAA documents, and briefing books Lead author of numerous supporting documents such as summary of changes, patient narratives, and IB updates Assists in planning and content creation for kick off meetings (ie, slide deck authoring) Collaborates with nonclinical, clinical safety, biometrics, and clinical development personnel to obtain status updates and plan documents Assists in the review of statistical analysis plans, and mock and draft statistical tables, listings and figures (TLFs) Participates in regulatory and clinical team strategy meetings to ensure that results and messages in clinical documents accurately reflect the data in TFLs and other information sources Assists in resolving team and quality control comments to ensure all comments are appropriately addressed Assists with team training for document processes and software Supports key pilot programs in medical writing such as new process development Ensures documents are generated in accordance with agreed internal processes and standards, are submission ready, and are appropriately stored in document management system(s). Requirements: Bachelor's degree in medically-related field or life science, with a minimum of 3 years of relevant medical writing experience in the pharmaceutical industry Master's or doctoral degree with 2 years of relevant medical writing experience in the pharmaceutical industry Familiarity with basic statistical analysis concepts and techniques is helpful Knowledge of clinical research concepts, practices, and FDA regulations and ICH Guidelines regarding drug development phases, clinical research, and medical writing standards; and demonstrated ability to interpret and apply these guidelines to document writing. A demonstrated track record of contribution to successful clinical documents such as IBs, CSRs, protocols, and protocol amendments Prior experience in interacting with cross-functional study team members is desirable Proficient in the use of MS Word, Excel, EndNote, Adobe Acrobat, and PowerPoint California pay range $100,000-$150,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Manager, Product Development & Operations is accountable for the project and is responsible for the indirect management of CMC project teams from process development to delivery of finished goods to depots or 3PL(s). They will manage both internal and external CMC activities. They may manage external relationships and may act as the primary contact for outsourced contract manufacturing organizations (CMO) and contract research organizations (CRO) involved with the development, analysis, distribution, manufacturing, packaging, and labeling for Arrowhead drug development programs. The Manager, Product Development & Operations will facilitate team collaboration to identify risks, challenges, and opportunities for the project. They will work with Arrowhead leadership to prioritize work and assign tasks. They will manage vendor onboarding, contracts, project budgets, timelines, KPIs and deliverables. This is a non-laboratory position with responsibilities that require cross- functional collaboration with team members from technical, legal, finance, clinical, commercial, logistics, supply chain, quality, and regulatory functions. Responsibilities Oversee global operational activities: development, manufacturing, warehousing, distribution, supply chain, logistics Act as primary point of contact for projects, facilitating communication between internal and external team members for CMC development, analytical, manufacturing, packaging, and labeling and distribution activities Partner with the cross functional project team (chemistry, analytical, quality, regulatory, supply chain, clinical operations, commercial, marketing) to deliver quality product on time Communicate project status and vendor activities to Arrowhead management and stakeholders Monitor internal and external inventory of intermediates, API, investigational product, retains, samples, and clinical supplies Manage budget, timeline, quality and deliverables for each project and vendor Develop and implement global process standards, best practices Develop and maintain and report KPIs for projects and external partners Generate and maintain project tracking tools using Smartsheet, Excel, Power Bi and other databases Work with technical, legal and finance groups to draft RFPs, track, manage and negotiate new contracts, supply agreements, confidentiality agreements, purchase orders, etc… for new and existing venders Track and review vendor invoices; collaborate with finance department to process payments Lead project meetings, vendor visits and conference calls Oversee shipments and storage of GLP, GMP, and clinical materials in accordance with Arrowhead SOPs and GDP Collaborate with clinical supply and supply chain to ensure materials are ready for current and up-coming developmental programs Requirements Bachelor's degree in a scientific discipline (e.g., Chemistry, Chemical Engineering, Biochemistry, or Biotechnology) and a minimum of 3 years of experience in a pharmaceutical company, contract manufacturing organization (CMO), or contract research organization (CRO); or Master's degree in a scientific discipline (e.g., Chemistry, Chemical Engineering, Biochemistry, or Biotechnology) and at least 1 year of relevant experience in a pharmaceutical company, CMO, or CRO. 0-2 years in a project management or project coordination role Knowledge of applicable GLP, GMP, GDP and regulatory guidance for pharmaceutical manufacturing and testing Strong MS Office skills (Outlook, Excel, PowerPoint, and Word) Excellent verbal and written communication skills A detail oriented, organized, self-starter who endeavors to anticipate problems and seeks opportunities to grow the role and responsibilities at Arrowhead Ability to work prolonged periods at a desk and working on a computer. Aptitude for independently resolving competing priorities in a fast-paced environment Willingness and ability to travel on a limited basis ( Preferred: Previous experience in pharmaceutical manufacturing, operations, clinical supply, or project management roles Experience with Project Management Software such as Smart Sheet or MS Project Experience with an ERP system such as Microsoft Dynamics (D365) or SAP GLP or GMP Laboratory or Manufacturing experience Wisconsin pay range $100,000-$115,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position This role provides clinical pharmacology and pharmacometrics leadership for assigned development programs and may be based in San Diego, CA or Madison, WI. The position is responsible for contributing to clinical trial design, authoring key protocol and regulatory sections, and performing hands-on PK/PD analyses to guide dose selection and program strategy. It oversees the preparation and authorization of PK analysis reports, CSR content, and clinical pharmacology components of global regulatory submissions Responsibilities Provide Clinical Pharmacology and pharmacometrics leadership for designated programs, contribute to design of clinical trial protocols and relevant sections in Investigational Brochure (IB), conduct hands-on analysis of clinical or translational PKPD data, support dosing strategies and clinical pharmacology planning. Authorize clinical PK analysis reports and relevant sections in the Clinical Study Report (CSR). Provide high quality documentation of clinical pharmacology analysis compatible with global regulatory submission requirements. Authorize clinical pharmacology modules of CTD to support global filings of marketing application. Provide timely communication of analysis results and interpretation with drug development teams. Maintain a current understanding of clinical pharmacology literature and regulatory guidance for oligonucleotide/RNAi therapeutics Requirements PhD or PharmD in the field of pharmacokinetics, pharmacology or pharmaceutical science, 3 years of pharmaceutical industry experience in clinical-stage drug development. Good understanding of FDA/EMA/ICH guidance related to clinical pharmacology Established experience in clinical NCA PK analysis and data reporting using Phoenix WinNonlin with familiarity of authorizing PK study report. Proficiency in NONMEM and skill of population PKPD modeling is essential. Preferred: PBPK/PD modeling California pay range $120,000-$170,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Data Reviewer will ensure the quality of laboratory data and reports produced within Analytical Development (AD). This includes the review of analytical testing data and related notebooks as specified by Standard Operating Procedures (SOPs). This position will evaluate data to ensure compliance with analytical methods, specifications, Good Laboratory Practices (GLP) or Good Manufacturing Practices (GMP). Responsibilities: Evaluates laboratory data from AD for compliance with analytical methods, specifications, and SOPs. Reviews sample analysis results from AD for completeness and accurate representation of the data and report findings Communicates with AD laboratory staff to proactively address the quality of laboratory documentation. Prepares statements noting deficiencies with the analytical data set or notebooks and reports deficiencies to the laboratory staff and/or project leader for correction. Conducts SOP preparation and review as well as consultation for GMP and Quality records. Performs other duties as assigned. Requirements: Bachelor's degree in Chemistry (or related scientific field). 3+ years' relevant experience (pharmaceutical CMO/CRO). Knowledge of cGMP guidelines for contract manufacturing and analytical laboratories and ICH/FDA guidance documents. Strong verbal and written communication skills and ability to work with diverse professionals in a matrix environment. Solid organizational skills with ability to adapt to changing priorities and deadlines. Wisconsin pay range $70,000-$85,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Facilities Technician II position will support building operations during 2nd shift hours (starting at 1:00 PM). This position offers scheduling flexibility, with a choice of a 4-day workweek (four 10-hour shifts, Monday-Thursday) or a traditional 5-day schedule (five 8-hour shifts, Monday-Friday). As the sole Facilities representative on second shift, the position will play a critical role in maintaining the safety, functionality, and appearance of our manufacturing and building infrastructure. This position is well suited for someone who thrives in a hands-on, independent work environment and takes pride in keeping complex facilities running smoothly and efficiently. This position will serve as the primary point of contact for all facilities-related matters during second shift and must be comfortable making real-time decisions with minimal supervision. Responsibilities will include routine maintenance, urgent repairs, contractor coordination, and ensuring smooth handoffs with first-shift teams. This role is eligible for a 10% shift differential. Responsibilities Serve as the primary Facilities point of contact during second shift, independently managing issues and ensuring timely resolution with minimal supervision. Respond promptly to urgent maintenance situations (e.g., leaks, power outages, equipment malfunctions), prioritizing safety and operational continuity. Perform routine building maintenance across multiple trades, including: Carpentry Painting and general repairs Plumbing Electrical General Cleaning HVAC support and diagnostics Participate in a rotating non-business hour on call program to respond to emergency building maintenance issues and system failures including holidays and weekends. Conduct regular inspections of building systems and infrastructure to identify and address maintenance needs proactively. Accurately complete and document daily work orders and maintenance records using appropriate tools and systems. Coordinate and oversee specialized contractors and OEM technicians, ensuring high-quality, compliant service on complex equipment. Take initiative to identify facility issues or improvement opportunities and resolve or escalate as needed. Strictly adhere to Environmental Health & Safety (EH&S) standards and internal procedures to maintain a safe and compliant working environment. Assist with inventory management of critical spare parts and consumables to minimize downtime. Ensure compliance with internal SOPs and external regulations, including cGMP, FDA, and OSHA guidelines. Maintain all required training certifications and job qualifications in alignment with regulatory and site requirements. Provide thorough shift handoffs, communicating effectively with first-shift personnel through logs, documentation, and in-person updates. Demonstrate continuous growth in technical knowledge, problem-solving ability, and cross-functional communication. Perform other duties as assigned. Requirements: High school diploma or equivalent required; post-secondary technical training a plus. Minimum of 5 years of hands-on facilities or maintenance experience. Proven knowledge in building systems maintenance, including: Basic carpentry, painting, and drywall repair Minor electrical work (e.g., lighting, outlets, ballasts) Plumbing (e.g., leaks, drains, line installs) HVAC troubleshooting and support Demonstrated ability to troubleshoot, prioritize, and resolve issues independently, particularly during off-hours or without direct supervision. Strong decision-making skills with a safety-first mindset and the ability to assess risk, root cause, and potential business impact in real time. Experience collaborating with cross-functional teams (e.g., engineering, quality, contractors) to implement maintenance solutions and improvements. Proficient in interpreting manuals, SOPs, and maintenance documentation. Comfortable working in GMP-regulated or highly compliant environments; understanding of FDA, OSHA, EPA, EH&S, and Wisconsin state safety standards preferred. Computer literacy, including working knowledge of Microsoft Office (Word, Excel, Outlook) and basic familiarity with digital work order systems (e.g., CMMS). Strong communication skills, with the ability to write clear shift handoffs and verbally convey technical information to non-technical audiences. Self-motivated, professional, and customer-oriented; takes initiative, follows through, and consistently delivers high-quality work. Preferred: Licensed tradesperson credentials such as a Journeyman Electrician or Refrigeration Technician license. Prior maintenance experience in a pharmaceutical, biotech, or similarly regulated environment. Familiarity with cGMP and cGDP principles, including proper documentation of maintenance work and maintaining clean, compliant workspaces. Experience using Computerized Maintenance Management Systems (CMMS) to manage work orders, asset history, and inventory. Resides within reasonable commuting distance of the facility and is available for occasional off-hours support. Wisconsin pay range $63,000-$73,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Lab Assistant supports the Quality Control team by maintaining the cleanliness of the chemical laboratories, equipment, and maintaining stock levels of inventory. Responsibilities Ability to closely follow written and verbal instructions Ability to clearly and concisely document reagent preps using lab notebooks or controlled forms Good verbal and written communication skills. Maintains glassware for the lab Maintains cleanliness and orderliness of work areas Maintains stocks of lab supplies and materials, ordering consumables, reagents, and chemicals as requested Follows safety procedures for chemical handling Prepares solutions and chemical reagents for laboratory use Executes training requirements, applies relevant SOPs and associated procedural guides Perform tasks in a timely manner Works collaboratively with others Quickly communicates issues to senior staff and/or management and assist in finding resolutions Maintains clear, concise, and accurate documentation and records according to Good Documentation Practices Embraces cGMP requirements for all associated work Remains flexible with changing priorities Requirements: Minimum of a high school diploma 1 years' experience working in a lab setting Preferred: Associate's Degree Experience in a GLP or GMP environment Wisconsin pay range $43,000-$47,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position This position works closely with Quality Assurance, Laboratory, and Manufacturing staff to complete and oversee Arrowhead's maintenance and calibrations for controlled Equipment. This position will maintain asset records and document the completion of work in Arrowhead's regulated asset management system. This position may be required to write minor equipment change controls and initiate deviations in Arrowhead's quality management system. Responsibilities Independently perform calibration to NIST standards and maintenance on manufacturing, facility, and process control systems, including, but not limited to: Synthesis and Purification systems Chromatography systems Lyophilization equipment Refrigeration Systems Vacuum Systems Bulk Tank Skids Pump Maintenance Temperature, pressure, and flow instruments Chemical formulation and distribution systems Process utility and waste collection systems Manage monthly assignments to reliably complete routine and non-routine maintenance and calibration tasks on time. Resolves complex roadblocks independently. Have knowledge and ability to perform a diverse set of routine maintenance and calibration tasks, including multi-step techniques of moderate complexity. Perform non-routine maintenance with a degree of independence. Recognize unusual circumstances and begins to identify root causes. Collaborate with manager and subject matter experts on problem solving and approaches to complex problems. Monitor process utility performance, including regular monitoring and testing to ensure reliable performance. Interface with regulated asset management system to track equipment statuses, document accurate work records, update asset records, and create calibration certificates following good documentation practices. Support vendors who are on-site performing services, including oversight of work documentation. Execute or oversee vendor completion of well-defined equipment and analytical instrument qualification protocols for complex systems. Proficient in safety programs. Independently follows safe work procedures and identifies permits needed for non-routine situations. Collaborate with cross-functional teams to complete a hazards assessment. Completes permits for approval. Begins to train junior teammates in calibration, maintenance, or safety practices. Begins to recommend new approaches or techniques to current and new practices. Makes recommendations and supports teams with continuous improvements. Wear all appropriate PPE for the workspace including but not limited to: safety glasses, steel toe shoes, hard hat, vest, clean space gowning, Cryo gloves, electrical safety gloves, fall protection. Requirements: Associate's Degree in mechanics, electronics technology or similar field, and 8 years of experience in a laboratory/manufacturing calibration role. (Equivalent High School and work experience will be considered) At least 4 years of work experience servicing complex laboratory/manufacturing equipment Must be proficient with reading and understanding engineering drawings Knowledgeable and experienced with LOTO (lock out tag out) Experience with controlled documentation (SOP/WI) Proficient in Microsoft Office Word, Excel, PowerPoint, and similar software Excellent technical writing skills with high attention to detail Good verbal and written communication skills Follow written procedures and work instructions with attention to detail Adhere to manufacturing and laboratory safety policies and procedures Good collaboration skills with ability to work with department team members. Preferred: Calibration experience with conductivity, pressure, flow, level indicators, temperature, mass, time, balances, cromotography, rotational and general lab equipment Experience working on and trobleshoting automated systems. Experience following change control practices for equipment and computer systems. Experience working with Blue Mountain Regulatory Asset Management System Experience with safe work permits including hot work, line breaks, and working in electrically classified areas. Wisconsin pay range $75,000-$88,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Manager, Artwork & Labeling is a detail-oriented and results-driven individual with a strong understanding of graphic design, pharmaceutical packaging regulations, GMP standards and workload management. This person is responsible for the creation, management, and implementation of commercial product labelling artwork. This position liaises and promotes exchanges in Global Operations, as well as with Regulatory Affairs, Quality, Supply Chain Planning, Marketing and Global Affiliates to ensure labelling change requests comply with company standards and are implemented in accordance with regulations and production schedules. Responsibilities Align artwork process strategies with broader Supply Chain, Regulatory, Quality, and Commercial objectives. Establish and maintain global governance frameworks, including SOPs, KPIs, change controls, and audit readiness protocols. Define and implement artwork workflows, documentation controls, and system interactions with appropriate stakeholders to ensure process consistency, quality, and traceability. Collaborate with Packaging and Device Engineering on product label/artwork development. Manage mock-up and artwork requests for labeling components, from development through review and approval to production implementation. Collaborate with Regulatory Affairs to create mock-ups supporting regulatory submissions and licensing activities, ensuring project timelines and milestones are met. Prepare error-free mock-ups and artwork using graphic design software and tools, interfacing with other functions within Arrowhead as well as printing/packaging vendors. Arrowhead point of contact for artwork vendors. Coordinate with external vendors, Procurement, and Supply Chain to ensure timely production. Optimize production processes for maximum efficiency, quality, and on-time delivery. Research and assess global labeling regulations and guidance documents, assisting in the development of procedures, guidelines, and maintenance systems for labeling development, approval, and control, while maintaining documentation and logs both in hardcopy and electronically. Oversee global artwork change control processes and validation protocols. Other duties as assigned Requirements Bachelor's Degree in Graphic Design or a related field. 5 years of professional design experience. Proficiency in problem-solving, communication, technical writing, and organization. Knowledge of software programs such as Adobe InDesign, Illustrator, Acrobat, Word, Excel, PowerPoint, and Outlook. Strong understanding of regulatory compliance requirements (e.g., GMP, CCDS, HA submissions) and global artwork-related standards and best practices. Experience in pharmaceuticals, packaging, and workflow. Preferred: Regulatory certifications (e.g., RAC) or equivalent professional credentials Wisconsin pay range $90,000-$115,000 USDCalifornia pay range $105,000-$125,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position This position will work within the cGMP, GLP, and GCP-regulated Quality organization to provide validation and lifecycle support for computerized systems, software, and IT infrastructure that have been newly installed, upgraded, replaced, and/or modified. The in cumbent will be responsible for guiding, generating, reviewing, and/or approving system assessments, test scripts, change controls, process improvements, and data integrity and governance at the applicable points of the system lifecycle. The position will serve as the subject matter expert to provide compliance leadership and oversight for CSV projects, collaborating with business partners to maintain and improve computer system validation processes. Responsibilities Provides Quality guidance for CSV efforts related to requirements engineering, system risk assessments, and data integrity assessments. Reviews and approves validation documentation, including Validation Plans, Requirements Specifications, Risk Assessments, Functional Requirements Specifications, Testing Protocols, Requirements Trace Matrices, and Summary Reports Serve as an SME for CSV and maintain knowledge and information in the Computer System Validation area of expertise Review CSV documentation to ensure data integrity requirements are maintained Review and approve discrepancies / deviations encountered during qualification / validation activities Review, assess, and approve computerized system change controls Coordinate validation activities with key stakeholders Provide direction to validation contractors (if required) Communicate CSV approach in support of audits Prepare documentation and provide support for regulatory inspections and inspection readiness activities. Review and approve periodic reviews of system validation. Ensure appropriate remediation plans are determined for gaps identified during periodic reviews. Requirements: Bachelor's degree in an applicable science field. Additional Quality related certification desired, CQA, CQMP Minimum of 5 years of experience in a pharmaceutical/biotech company, contract manufacturing organization, or contract research organization with expanding responsibilities related to computerized system, equipment, and/or instrument qualification. Working knowledge of overall GMP and/or GLP FDA, EU, and ICH regulations. Preferred: Prior experience with use of an electronic document management system in a regulated environment. Wisconsin pay range $80,000-$95,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

The Associate Manufacturing Scientist I (second shift) will assist in the synthesis and subsequent purification steps of large scale oligonucleotides. The operator must comply with GLP/GMP protocols and be able to follow all association SOPs and work instructions when performing and documenting operations. 2nd shift work hours are 1pm - 11:30pm and includes a 10% shift differential. Responsibilities * Follow batch records, SOPs, and work instructions to detail * Document all operations in batch records and notebooks * Comply with GMP protocols * Assist other chemists within the CMC group during synthesis and chromatography of oligonucleotides including: * Reagent solution preparation * Column Packing * Mobile phase preparation * Fraction collection * Operate TFF to desalt purified RNA solutions * Operate a lyophilizer and package solid drug substance * Execute processes as part of a team to ensure production timelines are kept and quality product is produced * Maintain a clean work space * Maintain safety by wearing required personal protective equipment Requirements: * Bachelor's degree in chemistry, biochemistry, engineering, or related scientific field * Experience working in a GMP setting and controlled documentation * Good verbal and written communication skills * Ability to work in a team environment * Ability to pay attention to detail

Job Description Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Data Reviewer is responsible for ensuring the completion, quality, and compliance of laboratory data and reports produced within the Quality Control (QC) team. This includes the technical review of analytical testing data and related notebooks, forms, logbooks, and more as specified by Standard Operating Procedures (SOPs). This position will evaluate data to ensure compliance with analytical methods, specifications, Good Laboratory Practices (GLP) or Good Manufacturing Practices (GMP) standards. This position will manage deadlines for review completion and aid in the organization and maintenance of data. The ideal candidate will have experience with analytical testing, either in performance or technical review. Responsibilities: Evaluate QC laboratory data for compliance with analytical methods, protocols, specifications, and SOPs. Review sample analysis results for completeness and accurate representation of the data and report findings. Communicate with QC laboratory staff to proactively address the quality of laboratory documentation. Prepare statements noting deficiencies with the analytical data set or notebooks and reports deficiencies to the project leader for correction. Conduct SOP review and writing as well as conducts consultations for quality records. Work cross-functionally to harmonize data review practices and produce a consistent product. Perform other duties as assigned. Requirements: Bachelor's degree in Chemistry (or related scientific field). 2+ years' relevant experience (pharmaceutical CMO/CRO). Knowledge of cGMP and cGLP guidelines for contract manufacturing and analytical laboratories and ICH/FDA guidance documents. Strong verbal and written communication skills and ability to work with diverse professionals in a matrix environment. Solid organizational skills with ability to adapt to changing priorities and deadlines. Wisconsin pay range $70,000-$85,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Job Description Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Facilities Technician II position will support building operations during 2nd shift hours (starting at 1:00 PM). This position offers scheduling flexibility, with a choice of a 4-day workweek (four 10-hour shifts, Monday-Thursday) or a traditional 5-day schedule (five 8-hour shifts, Monday-Friday). As the sole Facilities representative on second shift, the position will play a critical role in maintaining the safety, functionality, and appearance of our manufacturing and building infrastructure. This position is well suited for someone who thrives in a hands-on, independent work environment and takes pride in keeping complex facilities running smoothly and efficiently. This position will serve as the primary point of contact for all facilities-related matters during second shift and must be comfortable making real-time decisions with minimal supervision. Responsibilities will include routine maintenance, urgent repairs, contractor coordination, and ensuring smooth handoffs with first-shift teams. This role is eligible for a 10% shift differential. Responsibilities Serve as the primary Facilities point of contact during second shift, independently managing issues and ensuring timely resolution with minimal supervision. Respond promptly to urgent maintenance situations (e.g., leaks, power outages, equipment malfunctions), prioritizing safety and operational continuity. Perform routine building maintenance across multiple trades, including: Carpentry Painting and general repairs Plumbing Electrical General Cleaning HVAC support and diagnostics Participate in a rotating non-business hour on call program to respond to emergency building maintenance issues and system failures including holidays and weekends. Conduct regular inspections of building systems and infrastructure to identify and address maintenance needs proactively. Accurately complete and document daily work orders and maintenance records using appropriate tools and systems. Coordinate and oversee specialized contractors and OEM technicians, ensuring high-quality, compliant service on complex equipment. Take initiative to identify facility issues or improvement opportunities and resolve or escalate as needed. Strictly adhere to Environmental Health & Safety (EH&S) standards and internal procedures to maintain a safe and compliant working environment. Assist with inventory management of critical spare parts and consumables to minimize downtime. Ensure compliance with internal SOPs and external regulations, including cGMP, FDA, and OSHA guidelines. Maintain all required training certifications and job qualifications in alignment with regulatory and site requirements. Provide thorough shift handoffs, communicating effectively with first-shift personnel through logs, documentation, and in-person updates. Demonstrate continuous growth in technical knowledge, problem-solving ability, and cross-functional communication. Perform other duties as assigned. Requirements: High school diploma or equivalent required; post-secondary technical training a plus. Minimum of 5 years of hands-on facilities or maintenance experience. Proven knowledge in building systems maintenance, including: Basic carpentry, painting, and drywall repair Minor electrical work (e.g., lighting, outlets, ballasts) Plumbing (e.g., leaks, drains, line installs) HVAC troubleshooting and support Demonstrated ability to troubleshoot, prioritize, and resolve issues independently, particularly during off-hours or without direct supervision. Strong decision-making skills with a safety-first mindset and the ability to assess risk, root cause, and potential business impact in real time. Experience collaborating with cross-functional teams (e.g., engineering, quality, contractors) to implement maintenance solutions and improvements. Proficient in interpreting manuals, SOPs, and maintenance documentation. Comfortable working in GMP-regulated or highly compliant environments; understanding of FDA, OSHA, EPA, EH&S, and Wisconsin state safety standards preferred. Computer literacy, including working knowledge of Microsoft Office (Word, Excel, Outlook) and basic familiarity with digital work order systems (e.g., CMMS). Strong communication skills, with the ability to write clear shift handoffs and verbally convey technical information to non-technical audiences. Self-motivated, professional, and customer-oriented; takes initiative, follows through, and consistently delivers high-quality work. Preferred: Licensed tradesperson credentials such as a Journeyman Electrician or Refrigeration Technician license. Prior maintenance experience in a pharmaceutical, biotech, or similarly regulated environment. Familiarity with cGMP and cGDP principles, including proper documentation of maintenance work and maintaining clean, compliant workspaces. Experience using Computerized Maintenance Management Systems (CMMS) to manage work orders, asset history, and inventory. Resides within reasonable commuting distance of the facility and is available for occasional off-hours support. Wisconsin pay range $63,000-$73,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The purpose of this position is to provide medical device quality assurance support at Arrowhead. This position will report to the Director, Supply Chain Quality and works closely with members of Quality, Operations, Supply Chain, Regulatory, and Commercial teams, as well as external stakeholders and suppliers. This position will provide Medical Device Subject Matter Expertise to support Quality and project teams to ensure clinical and commercial product quality are in compliance with relevant US and ROW medical device regulations, guidance, and laws. Responsibilities Serve as an internal medical device subject matter expert, both US and ROW, for all relevant elements of QMS and quality of combination product development and commercialization, assuring proper integration and support of device regulations, including, but not limited to Change Management, Risk Management, DHF/DMR Maintenance, Internal Audits, etc. Monitor, guide, and ensure internal stakeholders' decision-making and actions are consistent with QSR, ISO 13485, ISO 14189, Good Distribution Practices (GDP), relevant international laws and guidance, and Arrowhead policies and procedures. Develop, define, support, review, augment, and/or approve a variety of controlled documents to ensure adherence to Medical Device Regulations and requirements. Identify gaps in existing processes, as well as need for new processes. Collaborate with cross-functional teams for solution development and implementation. Provide quality guidance to internal stakeholders and project teams during all phases of design control, risk management, human factor engineering, process development, verification/validation testing, packaging, and distribution, as well as lifecycle management of design changes and documentation. Support continuous improvement to the combination product QMS, monitoring and identifying areas for improvement. Support development and management of Supplier Quality activities such as Quality Agreements, supplier audits, and assessment and performance evaluations (SCARs, Customer Notifications, etc.) Support internal audits, certifications, and regulatory inspections at Arrowhead and its suppliers. Review Clinical Study Plans that include device instructions. Requirements: BS/BA in an applicable scientific field such as chemistry, biology, or biochemistry is preferred Minimum of eight (8) years industry experience in Quality Assurance, in which at least five (5) of those years were in a leadership position with increasing levels of responsibility. Medical Device experience required. Combination Product and Supplier Quality experience preferred. Knowledge of GxP, focus on QMS, QSR, as well as ICH/FDA, EU MDR, ISO 13485 guidance documents and standards applicable to clinical and commercial products. Preferred: Works independently, is organized, can multi-task and adjust priorities in a fast-paced, dynamic work environment. Well-developed communication and interpersonal skills, with the ability to influence stakeholders at all levels. Ability to consistently communicate with external parties in a professional manner. Competent knowledge of and ability to use Microsoft Word, Excel, Adobe Acrobat, DocuSign, SharePoint and SmartSheet. Ability for occasional business Wisconsin pay range $130,000-$150,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

The Lab Assistant supports the Quality Control team by maintaining the cleanliness of the chemical laboratories, equipment, and maintaining stock levels of inventory. Responsibilities * Ability to closely follow written and verbal instructions * Ability to clearly and concisely document reagent preps using lab notebooks or controlled forms * Good verbal and written communication skills. * Maintains glassware for the lab * Maintains cleanliness and orderliness of work areas * Maintains stocks of lab supplies and materials, ordering consumables, reagents, and chemicals as requested * Follows safety procedures for chemical handling * Prepares solutions and chemical reagents for laboratory use * Executes training requirements, applies relevant SOPs and associated procedural guides * Perform tasks in a timely manner * Works collaboratively with others * Quickly communicates issues to senior staff and/or management and assist in finding resolutions * Maintains clear, concise, and accurate documentation and records according to Good Documentation Practices * Embraces cGMP requirements for all associated work * Remains flexible with changing priorities Requirements: * Minimum of a high school diploma * 1 years' experience working in a lab setting Preferred: * Associate's Degree * Experience in a GLP or GMP environment

Job Description Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Manager, Product Development & Operations is accountable for the project and is responsible for the indirect management of CMC project teams from process development to delivery of finished goods to depots or 3PL(s). They will manage both internal and external CMC activities. They may manage external relationships and may act as the primary contact for outsourced contract manufacturing organizations (CMO) and contract research organizations (CRO) involved with the development, analysis, distribution, manufacturing, packaging, and labeling for Arrowhead drug development programs. The Manager, Product Development & Operations will facilitate team collaboration to identify risks, challenges, and opportunities for the project. They will work with Arrowhead leadership to prioritize work and assign tasks. They will manage vendor onboarding, contracts, project budgets, timelines, KPIs and deliverables. This is a non-laboratory position with responsibilities that require cross- functional collaboration with team members from technical, legal, finance, clinical, commercial, logistics, supply chain, quality, and regulatory functions. Responsibilities Oversee global operational activities: development, manufacturing, warehousing, distribution, supply chain, logistics Act as primary point of contact for projects, facilitating communication between internal and external team members for CMC development, analytical, manufacturing, packaging, and labeling and distribution activities Partner with the cross functional project team (chemistry, analytical, quality, regulatory, supply chain, clinical operations, commercial, marketing) to deliver quality product on time Communicate project status and vendor activities to Arrowhead management and stakeholders Monitor internal and external inventory of intermediates, API, investigational product, retains, samples, and clinical supplies Manage budget, timeline, quality and deliverables for each project and vendor Develop and implement global process standards, best practices Develop and maintain and report KPIs for projects and external partners Generate and maintain project tracking tools using Smartsheet, Excel, Power Bi and other databases Work with technical, legal and finance groups to draft RFPs, track, manage and negotiate new contracts, supply agreements, confidentiality agreements, purchase orders, etc… for new and existing venders Track and review vendor invoices; collaborate with finance department to process payments Lead project meetings, vendor visits and conference calls Oversee shipments and storage of GLP, GMP, and clinical materials in accordance with Arrowhead SOPs and GDP Collaborate with clinical supply and supply chain to ensure materials are ready for current and up-coming developmental programs Requirements Bachelor's degree in a scientific discipline (e.g., Chemistry, Chemical Engineering, Biochemistry, or Biotechnology) and a minimum of 3 years of experience in a pharmaceutical company, contract manufacturing organization (CMO), or contract research organization (CRO); or Master's degree in a scientific discipline (e.g., Chemistry, Chemical Engineering, Biochemistry, or Biotechnology) and at least 1 year of relevant experience in a pharmaceutical company, CMO, or CRO. 0-2 years in a project management or project coordination role Knowledge of applicable GLP, GMP, GDP and regulatory guidance for pharmaceutical manufacturing and testing Strong MS Office skills (Outlook, Excel, PowerPoint, and Word) Excellent verbal and written communication skills A detail oriented, organized, self-starter who endeavors to anticipate problems and seeks opportunities to grow the role and responsibilities at Arrowhead Ability to work prolonged periods at a desk and working on a computer. Aptitude for independently resolving competing priorities in a fast-paced environment Willingness and ability to travel on a limited basis ( Preferred: Previous experience in pharmaceutical manufacturing, operations, clinical supply, or project management roles Experience with Project Management Software such as Smart Sheet or MS Project Experience with an ERP system such as Microsoft Dynamics (D365) or SAP GLP or GMP Laboratory or Manufacturing experience Wisconsin pay range $100,000-$115,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Job Description Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position This position works closely with Quality Assurance, Laboratory, and Manufacturing staff to complete and oversee Arrowhead's maintenance and calibrations for controlled Equipment. This position will maintain asset records and document the completion of work in Arrowhead's regulated asset management system. This position may be required to write minor equipment change controls and initiate deviations in Arrowhead's quality management system. Responsibilities Independently perform calibration to NIST standards and maintenance on manufacturing, facility, and process control systems, including, but not limited to: Synthesis and Purification systems Chromatography systems Lyophilization equipment Refrigeration Systems Vacuum Systems Bulk Tank Skids Pump Maintenance Temperature, pressure, and flow instruments Chemical formulation and distribution systems Process utility and waste collection systems Manage monthly assignments to reliably complete routine and non-routine maintenance and calibration tasks on time. Resolves complex roadblocks independently. Have knowledge and ability to perform a diverse set of routine maintenance and calibration tasks, including multi-step techniques of moderate complexity. Perform non-routine maintenance with a degree of independence. Recognize unusual circumstances and begins to identify root causes. Collaborate with manager and subject matter experts on problem solving and approaches to complex problems. Monitor process utility performance, including regular monitoring and testing to ensure reliable performance. Interface with regulated asset management system to track equipment statuses, document accurate work records, update asset records, and create calibration certificates following good documentation practices. Support vendors who are on-site performing services, including oversight of work documentation. Execute or oversee vendor completion of well-defined equipment and analytical instrument qualification protocols for complex systems. Proficient in safety programs. Independently follows safe work procedures and identifies permits needed for non-routine situations. Collaborate with cross-functional teams to complete a hazards assessment. Completes permits for approval. Begins to train junior teammates in calibration, maintenance, or safety practices. Begins to recommend new approaches or techniques to current and new practices. Makes recommendations and supports teams with continuous improvements. Wear all appropriate PPE for the workspace including but not limited to: safety glasses, steel toe shoes, hard hat, vest, clean space gowning, Cryo gloves, electrical safety gloves, fall protection. Requirements: Associate's Degree in mechanics, electronics technology or similar field, and 8 years of experience in a laboratory/manufacturing calibration role. (Equivalent High School and work experience will be considered) At least 4 years of work experience servicing complex laboratory/manufacturing equipment Must be proficient with reading and understanding engineering drawings Knowledgeable and experienced with LOTO (lock out tag out) Experience with controlled documentation (SOP/WI) Proficient in Microsoft Office Word, Excel, PowerPoint, and similar software Excellent technical writing skills with high attention to detail Good verbal and written communication skills Follow written procedures and work instructions with attention to detail Adhere to manufacturing and laboratory safety policies and procedures Good collaboration skills with ability to work with department team members. Preferred: Calibration experience with conductivity, pressure, flow, level indicators, temperature, mass, time, balances, cromotography, rotational and general lab equipment Experience working on and trobleshoting automated systems. Experience following change control practices for equipment and computer systems. Experience working with Blue Mountain Regulatory Asset Management System Experience with safe work permits including hot work, line breaks, and working in electrically classified areas. Wisconsin pay range $75,000-$88,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Job Description Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Manager, Artwork & Labeling is a detail-oriented and results-driven individual with a strong understanding of graphic design, pharmaceutical packaging regulations, GMP standards and workload management. This person is responsible for the creation, management, and implementation of commercial product labelling artwork. This position liaises and promotes exchanges in Global Operations, as well as with Regulatory Affairs, Quality, Supply Chain Planning, Marketing and Global Affiliates to ensure labelling change requests comply with company standards and are implemented in accordance with regulations and production schedules. Responsibilities Align artwork process strategies with broader Supply Chain, Regulatory, Quality, and Commercial objectives. Establish and maintain global governance frameworks, including SOPs, KPIs, change controls, and audit readiness protocols. Define and implement artwork workflows, documentation controls, and system interactions with appropriate stakeholders to ensure process consistency, quality, and traceability. Collaborate with Packaging and Device Engineering on product label/artwork development. Manage mock-up and artwork requests for labeling components, from development through review and approval to production implementation. Collaborate with Regulatory Affairs to create mock-ups supporting regulatory submissions and licensing activities, ensuring project timelines and milestones are met. Prepare error-free mock-ups and artwork using graphic design software and tools, interfacing with other functions within Arrowhead as well as printing/packaging vendors. Arrowhead point of contact for artwork vendors. Coordinate with external vendors, Procurement, and Supply Chain to ensure timely production. Optimize production processes for maximum efficiency, quality, and on-time delivery. Research and assess global labeling regulations and guidance documents, assisting in the development of procedures, guidelines, and maintenance systems for labeling development, approval, and control, while maintaining documentation and logs both in hardcopy and electronically. Oversee global artwork change control processes and validation protocols. Other duties as assigned Requirements Bachelor's Degree in Graphic Design or a related field. 5 years of professional design experience. Proficiency in problem-solving, communication, technical writing, and organization. Knowledge of software programs such as Adobe InDesign, Illustrator, Acrobat, Word, Excel, PowerPoint, and Outlook. Strong understanding of regulatory compliance requirements (e.g., GMP, CCDS, HA submissions) and global artwork-related standards and best practices. Experience in pharmaceuticals, packaging, and workflow. Preferred: Regulatory certifications (e.g., RAC) or equivalent professional credentials Wisconsin pay range $90,000-$115,000 USDCalifornia pay range $105,000-$125,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The Position The Associate Manufacturing Scientist I (second shift) will assist in the synthesis and subsequent purification steps of large scale oligonucleotides. The operator must comply with GLP/GMP protocols and be able to follow all association SOPs and work instructions when performing and documenting operations. 2 nd shift work hours are 1pm - 11:30pm and includes a 10% shift differential. Responsibilities Follow batch records, SOPs, and work instructions to detail Document all operations in batch records and notebooks Comply with GMP protocols Assist other chemists within the CMC group during synthesis and chromatography of oligonucleotides including: Reagent solution preparation Column Packing Mobile phase preparation Fraction collection Operate TFF to desalt purified RNA solutions Operate a lyophilizer and package solid drug substance Execute processes as part of a team to ensure production timelines are kept and quality product is produced Maintain a clean work space Maintain safety by wearing required personal protective equipment Requirements: Bachelor's degree in chemistry, biochemistry, engineering, or related scientific field Experience working in a GMP setting and controlled documentation Good verbal and written communication skills Ability to work in a team environment Ability to pay attention to detail Wisconsin pay range $63,000-$73,000 USD Arrowhead provides competitive salaries and an excellent benefit package. All applicants must have authorization to work in the US for a company. California Applicant Privacy Policy