Asimov jobs in Boston, MA - 23 jobs

A leading synthetic biology company in Boston is seeking a Head of Cell Line Development to lead its CLD team and advance biologics manufacturing. The ideal candidate will drive excellence in workflows and serve as a scientific leader, collaborating with cross-functional teams. The successful applicant will need a Ph.D. and over 10 years of experience in CHO-based cell line development. This role offers a chance to influence innovative biotechnologies in a growing organization committed to diversity and excellence. #J-18808-Ljbffr

Our mission at Asimov is to radically advance humankind's ability to design living systems. We're developing a mammalian synthetic biology platform-from cells to software-to enable biotechnologies with outsized impact, with an initial focus on gene therapies, cell therapies, and protein therapeutics. What would software engineering be like without an IDE? How could humans design a modern plane without CAD? Genetic engineering will be even more demanding-and we're building the tools to make it possible. Kernel is our platform for bioengineers to design, build, and debug genetic systems as confidently as we ship code. We're looking for a Senior Software Engineer to help us build it. You'll join an interdisciplinary team that works directly with scientists, synthetic biologists, and computational biologists alongside your teammates in software engineering and product. About the Role: Design GraphQL APIs for searching, editing and analyzing tens of thousands of genetic constructs using Python 3, SQLAlchemy and Strawberry. Shape the software architecture and be involved in the long-term product direction. Collaborate on data models that represent the genuine complexity of biological systems. Interface directly with synthetic biologists to understand their workflows and identify tools that would transform their productivity. Be part of an on-call rotation to support the software you've helped develop. About You: You have 6+ years building production software - systems that other engineers depend on, not research code that runs once. You have expertise in Python 3 and ideally experience with GraphQL, SQLAlchemy, and/or Strawberry. You're the kind of engineer who loses track of time working on an interesting technical problem. You want challenges that will have you waking up with a new idea that you can't wait to try. You want to help design a product with a close-knit team, not just write code from predefined specifications. You can navigate the ambiguity of building something first‑of‑its‑kind. We're fueled by a vision to transform biological engineering into a fully‑fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives. #J-18808-Ljbffr

Job Description Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform-from cells to software-to enable the design and manufacture of next-generation therapeutics. We are searching for a Senior Computational Biologist with multi-disciplinary skills in computational biology, machine learning, and applied mathematics to join our team. This role bridges the gap between sequence-level design and systems-level dynamics, focusing on the development and application of sophisticated models that integrate diverse biological data. The ideal candidate will be adept at building data-driven, mechanistic, and hybrid models to decipher complex biological processes and guide the engineering of therapeutic molecules and systems. You will leverage everything from high-dimensional omics datasets to time-course bioprocess data to create predictive models that drive genetic design and optimize bioprocess development. Join our team to contribute at the cutting-edge of innovation in biology and computational science, shaping the future of therapeutic innovation. About the Role: Design and implement sophisticated models-including data-driven (ML/AI), mechanistic (e.g., ODE-based), and hybrid approaches-to predict and optimize the performance of biologics and vector manufacturing processes. Develop models that predict functional outcomes such as transgene expressibility, protein stability, and product quality attributes from nucleic acid and amino acid sequence features Develop new models to predict developability attributes such as expressibility, secretability, aggregation, and stability of biologics, from sequence. Create multi-scale models of cellular behavior, integrating omics data (RNA-seq, proteomics, etc.) to simulate gene expression, protein secretion dynamics, metabolism, and cell phenotype. Work in close collaboration with bench scientists to guide rational experimental design, using techniques like Bayesian Optimization to ensure that data generation is maximally informative for modeling and yields actionable insights. Contribute to our long-term computational strategy by exploring novel algorithms, modeling frameworks, and data integration techniques to solve critical challenges in synthetic biology and therapeutic development. About You: You have a Ph.D. in Bioengineering, Computational Biology, Computer Science, Applied Mathematics, or a related quantitative field. You are proficient in sequence-based analysis and have hands-on experience integrating large-scale omics datasets (e.g., NGS, RNA-seq, proteomics) to inform model development and validation. You are an expert in applying machine learning and advanced mathematical techniques (e.g., dynamical systems, differential equations, stochastic modeling) to biological systems, with at least 3 years of experience in a pharmaceutical or biotechnology industry setting. You have a strong background in modeling dynamic biological systems, such as gene regulatory networks, metabolic pathways, or cell population dynamics. You are a skilled programmer, fluent in Python and associated scientific computing/ML libraries. You excel at communicating complex scientific and mathematical concepts effectively to colleagues with diverse backgrounds and expertise. You are a collaborative, impact-driven scientist, passionate about working in a fast-paced, research-focused environment to engineer biology. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives. Compensation Range: $150K - $175K

Job Description Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform-from cells to software-to enable the design and manufacture of next-generation therapeutics. We are seeking a Scientist I/II, Viral Vector Process Development to join our team in Boston, MA and help push the boundaries of gene therapy process development. This role is for a technical expert who will conduct lentiviral (LV Edge) and adeno-associated viral (AAV Edge) vector-based process engineering for gene therapies, design complex experimental approaches to improve our workflows and systems, and coordinate project efforts. While primarily focused on viral vector process engineering, there is a high degree of cross-functionality within the Process Development group that will also include working on biologics processes (CHO Edge). The successful candidate will work closely with Asimov's Synthetic Biology and Cell Line Development teams, as well as interfacing with external partners. This role reports to the Head of Process Development and is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the future of biological engineering. About the Role: Be involved in projects that include media/feed optimization, bioreactor process development, process scale-up and characterization at Ambr15, Ambr250, and benchtop scale, along with analytical assay development focused primarily on LV/AAV, with overlap into biologics. Work together with the Commercial team to technology transfer developed upstream processes to external partners. Create and optimize throughput and robustness of workflows for cell line characterization (transient/stable), small scale screening assays, and product quality assessment. Collaborate with our internal process modeling team to test hypotheses for developing robust predictive models using DOE approaches, machine learning algorithms, and multi-omics analysis. Author, review, and approve process development reports and technology transfer protocols. Support clarifications, downstream processing/purification, and product quality assessment with analytical tools. Represent the process development team on cross-functional projects, making decisions for process development activities and effectively communicating results, progress and plans. About You: You have a Bachelors in Biological Engineering, Chemical Engineering, Cell Biology, Molecular Biology, or a related field with 6-8 years of hands-on industry experience performing viral vector process development in support of gene therapies; alternatively, a MS with 3-4 years or PhD with 0-2 years of this type of experience. You're a creative problem solver and get excited about the opportunity to drive the creation of industry-disruptive technology. HEK293-based viral vector process development is squarely in your wheelhouse. Additional CHO-based experience is not required but preferable. You have experience with Ambr15, Ambr250, and/or benchtop scale viral vector bioreactor processes. Analytical development and downstream purification experience is also highly preferable. Being detail-oriented isn't just a sound bite for you, it's part of your DNA. Keeping track of a bunch of moving parts is easy for you because you're highly organized. It's not your first time following a standardized workflow or pipeline. Experience in the technology transfer of manufacturing processes and CMC filing in the pharmaceutical industry is desirable. You are an expert in spreadsheets such as Google Sheets or Excel and ideally Spotfire, Google Apps Script (JavaScript) and/or BigQuery to facilitate data management and analysis. Experienced with using DOE software to develop robust experiments. Familiarity with implementing algorithm-based design approaches is a plus. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives. Compensation Range: $120K - $130K

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform-from cells to software-to enable the design and manufacture of next-generation therapeutics. We are seeking a Senior Research Associate to join our DNA & Strain Construction team in Boston, MA. The ideal candidate will have a proven track record designing and constructing plasmids, using different assembly strategies. They will be a key contributor to our team, working closely with other DNASC team members using the latest molecular biology and automation techniques to help advance our high throughput DNA construction pipeline, at the same pushing the limits of DNA assembly capabilities. They will also work closely with Asimov's Synthetic Biology, High Throughput and Cell Line Development teams. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the foundation for engineering biology. About the Role: Conduct PCR, Golden Gate or Gibson Assembly, plasmid purification, and sequencing prep to validate DNA constructs, both manually and in high-throughput using liquid handlers (e.g., Echo, Bravo, Hamilton STAR) following Standard Operation Procedures (SOPs) Contribute to vector assembly design, and remediation plans. Work with your manager to generate regulatory reports to support our customers' needs. Maintain accurate sample tracking and documentation in LIMS to ensure data integrity and reproducibility. Assist with large-scale plasmid preparations (LSPs) to support internal and external projects. Collaborate with scientists and other RAs to troubleshoot workflows, improve efficiency and develop new initiatives within the team. Work as part of a multifunctional team, you'll partner with synthetic biologists on the DNASC team as well as members of the Cell Line Development, Synthetic Biology and Software Development teams. About You: You have a B.S. or M.S. degree in biology, biochemistry, biological engineering, or a related field. Deep bench experience is necessary to be successful in this role, and you will have 3+ years of biopharma experience. You value teamwork and are motivated to contribute to the team's goals. Working as part of a highly integrated research team is exciting to you. Automation experience is a plus but a desire to learn to develop automation of lab experiments is a must. You will have independently or collaboratively designed an assembly plan to generate plasmids using either Gibson or Golden Gate. You have experience, outside of coursework, with modern molecular biology and/or microbiological techniques such as various DNA assembly methods (Golden Gate, Gibson), PCR, colony picking, and DNA preps. Being detail-oriented isn't just a sound bite for you, it's part of your DNA. Experience with optimizing cloning protocols (PCR, Gibson, and especially Golden Gate) and basic mammalian cell culture techniques is a plus. Experience extracting data using scripts from large databases or desire to learn is a plus. We're big on tools here! We're happy to train you but if you know your way around Benchling, LIMS, Google Drive, and Excel, it'll help you come up to speed quickly. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform-from cells to software-to enable the design and manufacture of next-generation therapeutics. We are seeking a Scientist, Biologics Cell Line Development to join our team in Boston, MA and help push the boundaries of biotherapeutic cell line development. This role is for a technical expert who will conduct CHO-based cell line engineering for biologic therapeutics, design complex experimental approaches to improve our workflows and systems, coordinate project efforts, and mentor junior scientists. The successful candidate will also work closely with Asimov's synthetic biology and process development teams. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the future of biological engineering.About the Role: You'll perform CHO cell line development processes including transfection, cloning, characterization, and cell banking using state-of-the-art equipment. You'll drive innovation through the development of novel cell line development workflows and applications. You'll identify emerging practices for biologics cell line development and manufacturing to shape scientific strategies and develop improved workflows. You'll represent the cell line development team on cross-functional projects, making decisions for cell line activities and effectively communicating results, progress and plans. About You: You have a Ph.D. in Biological Engineering, Cell Biology, Molecular Biology, or a related field with Your training has provided you with a depth of knowledge in areas of biology relevant to how mammalian cells regulate transcription, translation, protein folding & assembly, intracellular trafficking and/or secretion. You have an interest in genetically engineering cells to support clinical development of human therapeutics. You have established yourself as an emerging innovator and are interested in applying your knowledge and curiosity to work collaboratively and cross functionally to develop enhanced platforms for production of therapeutic proteins. You're a creative problem solver and get excited about the opportunity to drive the creation of industry-disruptive technology. You are an expert in spreadsheets such as Google Sheets or Excel and ideally Spotfire, Google Apps Script (JavaScript) and/or BigQuery to facilitate data management and analysis. You are experienced with electronic lab notebooks (Benchling) and document your experiment meticulously. Prior experience genetically engineering CHO cells to express mAbs & bs Abs is desirable but not required. Don't let this stop you from applying, but it's also a plus if you are familiar with cell culture liquid handling automation, ambr bioreactors, and/or dd PCR. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

A synthetic biology company in Boston is seeking a Senior Software Engineer to design GraphQL APIs for their innovative platform. This role involves working closely with scientists to shape software architecture and improve productivity in biological engineering. Ideal candidates will have over 6 years of production software experience, particularly with Python 3, GraphQL, and SQLAlchemy. Join a diverse team dedicated to pushing the frontiers of synthetic biology in a collaborative environment. #J-18808-Ljbffr

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform-from cells to software-to enable the design and manufacture of next-generation therapeutics. We are seeking a strategic and hands-on Senior Accounting Manager to establish and lead our accounting operations. In this newly created role, and reporting to the Head of Commercial, you will be responsible for ensuring accurate revenue recognition, supporting budgeting and forecasting, streamlining and implementing processes, while overseeing all accounts payable and receivable activities. This role offers the unique opportunity to design and optimize financial systems from the ground up within a rapidly growing biotech startup. The ideal candidate will thrive in a collaborative, science-driven environment while bringing financial rigor, process discipline, and forward-thinking leadership to drive innovation and fuel the company's next phase of growth. About the Role: Accounting & Controls: Ensure timely and accurate recording of revenue, COGS, and expenses across all product lines. Maintain reconciliations, accruals, and closing schedules. Audit & Compliance: Lead preparation for the annual audit, liaise with auditors on technical issues (e.g., revenue recognition, asset classification), and ensure compliance with tax and regulatory requirements. Budget Tracking: Monitor spend against budget, provide variance analyses, and maintain rolling forecasts with input from department leads. Systems & Processes: Recommend and implement scalable general ledger and procurement systems (e.g., Prendio or equivalents) to improve reporting, visibility, and spend control. Cash & Runway Visibility: Produce monthly cash flow reports, identify risks to runway, and flag required actions. Reporting: Prepare accurate and timely monthly/quarterly financial statements, management reports, and supporting schedules for leadership and investors. Payroll: Manage scalable payroll systems and processes, ensuring accuracy, timeliness, and compliance across multiple states, while partnering with HR to support an expanding and distributed workforce. About You: You have a Bachelor's or Master's degree in Accounting or Finance with 7+ years of progressive experience in accounting/finance. CPA certification is strongly preferred. You ideally have prior life sciences, biotech, or high-growth tools/services experience. You have strong technical accounting expertise, including revenue recognition, COGS tracking, accruals, and GAAP compliance. You have experience with audits, tax compliance, and working directly with external auditors. You are proficient with general ledger systems, procurement platforms, and financial reporting tools. You've demonstrated the ability to build scalable accounting processes and internal controls in a high-growth company. You have an analytical mindset with attention to detail; able to identify variances, trends, and risks early. You have excellent communication skills, able to translate accounting into clear business insights. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

Our mission at Asimov is to radically advance humankind's ability to design living systems, enabling biotechnologies with societal benefit. We're developing a mammalian synthetic biology platform-from cells to software-to enable biotechnologies with outsized impact, with an initial focus on gene therapies, cell therapies, and protein therapeutics. We are seeking a strategic, hands‑on Head of Finance to build and lead our finance and accounting function from the ground up. In this newly created role, and reporting to the Head of Commercial, you will establish core financial processes, ensure accurate revenue recognition, support budgeting and forecasting, while overseeing all accounts payable and receivable activities. This role offers the unique opportunity to design and optimize financial systems as a team of one within a rapidly growing biotech startup. The ideal candidate will thrive in a fast paced, collaborative environment while bringing financial rigor, process discipline, and forward‑thinking leadership needed to support scientific innovation and fuel the company's next phase of growth. About the Role: Accounting & Controls: Ensure timely and accurate recording of revenue, COGS, and expenses across all product lines. Maintain reconciliations, accruals, and closing schedules. Audit & Compliance: Lead preparation for the annual audit, liaise with auditors on technical issues (e.g., revenue recognition, asset classification), and ensure compliance with tax and regulatory requirements. Budget Tracking: Monitor spend against budget, provide variance analyses, and maintain rolling forecasts with input from department leads. Systems & Processes: Recommend and implement scalable general ledger and procurement systems (e.g., Prendio or equivalents) to improve reporting, visibility, and spend control. Cash & Runway Visibility: Produce monthly cash flow reports, identify risks to runway, and flag required actions. Reporting: Prepare accurate and timely monthly/quarterly financial statements, management reports, and supporting schedules for leadership and investors. Payroll: Manage scalable payroll systems and processes, ensuring accuracy, timeliness, and compliance across multiple states, while partnering with HR to support an expanding and distributed workforce. Strategy: Serve as a strategic thought partner to leaders across the organization to align financial priorities with R&D, product, commercial and operations strategies. About You: You have a Bachelor's or Master's degree in Accounting or Finance with 10+ years of progressive experience in accounting/finance. CPA certification is strongly preferred. You have experience working in a high‑growth company, in the life sciences, biotech, or tools/services industry, You have strong technical accounting expertise, including revenue recognition, COGS tracking, accruals, and GAAP compliance. You have experience with audits, tax compliance, and working directly with external auditors. You are proficient with general ledger systems, procurement platforms, and financial reporting tools. You've demonstrated the ability to build scalable accounting processes and internal controls in a high‑growth company. You have an analytical mindset with attention to detail; able to identify variances, trends, and risks early. You have excellent communication skills, able to translate accounting into clear business insights. We're fueled by a vision to transform biological engineering into a fully‑fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives. #J-18808-Ljbffr

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform-from cells to software-to enable the design and manufacture of next-generation therapeutics. We are seeking a Senior Associate Scientist, Viral Vector to join our Cell Line Development team in Boston, MA. The ideal candidate will have a proven track record performing lentiviral vector stable packaging or producer cell line development in an industry setting. They will be a key contributor to our team, participating in the creation of stable producer cell lines for lentiviral vector therapeutics and research projects to improve our cell line development workflows. They will also work closely with Asimov's synthetic biology and process development teams. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the future of biological engineering.About the Role: Perform lentiviral vector stable producer cell line development processes including transfection, pool generation, single cell cloning, characterization, and cell banking using state-of-the-art equipment. Perform assays to assess quantity, potency and infectivity of lentiviral vector preparations. Support innovation through development of novel workflows and applications Support research projects to develop viral vector production methods to enhance product quality attributes such as empty/full ratio, potency and/or cell targeting. Work effectively as part of a cross-functional team in support of a Lentiviral CLD platform and in collaboration with Synthetic Biology and Process Development teams. Design experiments, analyze data, troubleshoot, and maintain detailed records. Represent LV CLD on project teams, making decisions for cell line development activities and effectively communicating results, progress and plans. About You: B.S or M.S. in Biological Engineering, Virology, Cell Biology, Molecular Biology, or a related field. 5+ years of hands-on experience in biopharma with a minimum of 3 years focused on lentiviral vector producer cell line development in support of GLP or GMP production of cell or gene therapies. Extensive experience performing viral transductions, flow cytometry, and quantitative gene expression analyses (dd PCR or qPCR). Experience with downstream purification of lentiviral vectors, T-cell transduction assay, viral genome engineering, and/or host cell genome engineering related to virus production or producer cell line technologies is highly desired. Comfortable working with large, multidimensional datasets and applying statistical or computational methods to extract actionable biological or process insights. Strong written and verbal communication skills required. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We've built a mammalian synthetic biology platform - from cells to software - to enable the design and manufacture of next-generation therapeutics. We are seeking a Head of Cell Line Development (CLD) to lead Asimov's biologics CLD team and help push the boundaries of biologics manufacturing. The successful candidate will be responsible for managing direct reports and lab activities in support of the generation and characterization of cell lines expressing the highest quantity and quality of protein therapeutics. We have experienced rapid growth in both our project portfolio and CLD team, and we expect that growth trajectory to continue for the foreseeable future. This role will be central to scaling capabilities, workflows, and leadership structures accordingly. This role requires a strategic leader with a deep technical foundation in biologics cell line development and a proven track record of growing and managing high-performing teams. Working closely with Asimov's synthetic biology, process development, computational modeling, and software teams, this role will shape Asimov's CLD vision and contribute as a thought leader to advance the state of the art in biologics cell line development. The role will also partner with commercial, program management, and technical teams to support customer-facing communications, including scientific discussions with prospective clients and collaborators. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology company. About the Role: As the Head of CLD, you'll lead and develop Asimov's CLD team, managing scientists and research associates focused on CHO-based biologics CLD. You'll guide individuals and the team towards personal and professional development milestones, all in support of Asimov's vision and goals. You'll drive excellence in execution, ensuring robust, high-throughput workflows for stable clone generation, screening, and characterization to deliver production cell lines meeting titer, quality, and regulatory expectations. You'll address complex cell line development challenges by demonstrating and applying cross-functional knowledge and industry best practices. You'll foster cross-functional collaboration with Synthetic Biology, Process Development, Process Modeling, Computational Biology, and Software teams to integrate design, data, and automation capabilities. You'll serve as a scientific and technical thought leader, identifying and implementing emerging technologies in expression vector design, gene integration, host engineering, productivity optimization, and workflow improvements. You'll represent Asimov externally, contributing to industry conferences, industry forums such as AMBIC and BioPhorum, filing patents, and publishing peer-reviewed manuscripts. About You: You have a Ph.D. in Biological Engineering, Cell Biology, Molecular Biology, or a related field. You have 10+ years of experience in CHO-based cell line development supporting IND-enabling and/or GMP manufacturing activities. You have a deep understanding of cell biology, expression system design, gene integration technologies, and process-relevant analytics. You have a track record of strategic thinking and innovation, translating R&D advances into scalable, manufacturable platforms. You have proven experience managing a team of scientists, with a track record of developing scientists and supporting rigorous scientific execution. You are comfortable engaging with internal and external stakeholders and can clearly communicate scientific and strategic considerations to prospective partners or clients. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives. #J-18808-Ljbffr

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform-from cells to software-to enable the design and manufacture of next-generation therapeutics. We are searching for a Senior Computational Biologist with multi-disciplinary skills in computational biology, machine learning, and applied mathematics to join our team. This role bridges the gap between sequence-level design and systems-level dynamics, focusing on the development and application of sophisticated models that integrate diverse biological data. The ideal candidate will be adept at building data-driven, mechanistic, and hybrid models to decipher complex biological processes and guide the engineering of therapeutic molecules and systems. You will leverage everything from high-dimensional omics datasets to time-course bioprocess data to create predictive models that drive genetic design and optimize bioprocess development. Join our team to contribute at the cutting-edge of innovation in biology and computational science, shaping the future of therapeutic innovation. About the Role: Design and implement sophisticated models-including data-driven (ML/AI), mechanistic (e.g., ODE-based), and hybrid approaches-to predict and optimize the performance of biologics and vector manufacturing processes. Develop models that predict functional outcomes such as transgene expressibility, protein stability, and product quality attributes from nucleic acid and amino acid sequence features Develop new models to predict developability attributes such as expressibility, secretability, aggregation, and stability of biologics, from sequence. Create multi-scale models of cellular behavior, integrating omics data (RNA-seq, proteomics, etc.) to simulate gene expression, protein secretion dynamics, metabolism, and cell phenotype. Work in close collaboration with bench scientists to guide rational experimental design, using techniques like Bayesian Optimization to ensure that data generation is maximally informative for modeling and yields actionable insights. Contribute to our long-term computational strategy by exploring novel algorithms, modeling frameworks, and data integration techniques to solve critical challenges in synthetic biology and therapeutic development. About You: You have a Ph.D. in Bioengineering, Computational Biology, Computer Science, Applied Mathematics, or a related quantitative field. You are proficient in sequence-based analysis and have hands-on experience integrating large-scale omics datasets (e.g., NGS, RNA-seq, proteomics) to inform model development and validation. You are an expert in applying machine learning and advanced mathematical techniques (e.g., dynamical systems, differential equations, stochastic modeling) to biological systems, with at least 3 years of experience in a pharmaceutical or biotechnology industry setting. You have a strong background in modeling dynamic biological systems, such as gene regulatory networks, metabolic pathways, or cell population dynamics. You are a skilled programmer, fluent in Python and associated scientific computing/ML libraries. You excel at communicating complex scientific and mathematical concepts effectively to colleagues with diverse backgrounds and expertise. You are a collaborative, impact-driven scientist, passionate about working in a fast-paced, research-focused environment to engineer biology. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform-from cells to software-to enable the design and manufacture of next-generation therapeutics. We are looking for an experienced Staff Software Engineer to join our dynamic Software Engineering team. At Asimov, we are creating a state-of-the-art platform to program living cells, named Kernel, that allows bioengineers to design, build, and debug genetic systems at scale. You will be part of an interdisciplinary team that works directly with our internal group of scientists, synthetic biologists, and computational biologists as well as your teammates in software engineering and product.About the Role: Design, build, and maintain software tools that are used by bioengineers to advance the design and manufacture of biologics and gene therapies. Directly shape the software architecture and be involved in the long-term product direction. Work with a modern backend stack (Python 3, Strawberry, SQLAlchemy). Develop data models and schemas for the complex domain of biology. Be part of an on-call rotation to support the software you've helped develop. Interface directly with members of the synthetic biology team to identify and prioritize potential improvements to software systems. Contribute to Asimov's technology platform, direction, and culture. About You: You have 10+ years of experience in software development. You have technical expertise in Python 3, Strawberry, SQLAlchemy, GraphQL, Elasticsearch, Docker. You have a sense of urgency and a desire to work on challenging technical projects You have the ability to navigate the ambiguity of building something that is first-of-its-kind. You have multiple years of experience building and scaling systems to production-level workloads. You possess sound technical judgment that considers quality, performance, and product stage. You have a passion for joining a startup where autonomy, passion to learn, and excitement to engineer biology take precedence over process and ego. Experience developing computer-aided design software and/or scientific software applications is desired, though not required. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform-from cells to software-to enable the design and manufacture of next-generation therapeutics. We are seeking a Scientist I/II, Viral Vector Process Development to join our team in Boston, MA and help push the boundaries of gene therapy process development. This role is for a technical expert who will conduct lentiviral (LV Edge) and adeno-associated viral (AAV Edge) vector-based process engineering for gene therapies, design complex experimental approaches to improve our workflows and systems, and coordinate project efforts. While primarily focused on viral vector process engineering, there is a high degree of cross-functionality within the Process Development group that will also include working on biologics processes (CHO Edge). The successful candidate will work closely with Asimov's Synthetic Biology and Cell Line Development teams, as well as interfacing with external partners. This role reports to the Head of Process Development and is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the future of biological engineering. About the Role: Be involved in projects that include media/feed optimization, bioreactor process development, process scale-up and characterization at Ambr15, Ambr250, and benchtop scale, along with analytical assay development focused primarily on LV/AAV, with overlap into biologics. Work together with the Commercial team to technology transfer developed upstream processes to external partners. Create and optimize throughput and robustness of workflows for cell line characterization (transient/stable), small scale screening assays, and product quality assessment. Collaborate with our internal process modeling team to test hypotheses for developing robust predictive models using DOE approaches, machine learning algorithms, and multi-omics analysis. Author, review, and approve process development reports and technology transfer protocols. Support clarifications, downstream processing/purification, and product quality assessment with analytical tools. Represent the process development team on cross-functional projects, making decisions for process development activities and effectively communicating results, progress and plans. About You: You have a Bachelors in Biological Engineering, Chemical Engineering, Cell Biology, Molecular Biology, or a related field with 6-8 years of hands-on industry experience performing viral vector process development in support of gene therapies; alternatively, a MS with 3-4 years or PhD with 0-2 years of this type of experience. You're a creative problem solver and get excited about the opportunity to drive the creation of industry-disruptive technology. HEK293-based viral vector process development is squarely in your wheelhouse. Additional CHO-based experience is not required but preferable. You have experience with Ambr15, Ambr250, and/or benchtop scale viral vector bioreactor processes. Analytical development and downstream purification experience is also highly preferable. Being detail-oriented isn't just a sound bite for you, it's part of your DNA. Keeping track of a bunch of moving parts is easy for you because you're highly organized. It's not your first time following a standardized workflow or pipeline. Experience in the technology transfer of manufacturing processes and CMC filing in the pharmaceutical industry is desirable. You are an expert in spreadsheets such as Google Sheets or Excel and ideally Spotfire, Google Apps Script (JavaScript) and/or BigQuery to facilitate data management and analysis. Experienced with using DOE software to develop robust experiments. Familiarity with implementing algorithm-based design approaches is a plus. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

Job Description Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform-from cells to software-to enable the design and manufacture of next-generation therapeutics. We are seeking a Senior Research Associate to join our DNA & Strain Construction team in Boston, MA. The ideal candidate will have a proven track record designing and constructing plasmids, using different assembly strategies. They will be a key contributor to our team, working closely with other DNASC team members using the latest molecular biology and automation techniques to help advance our high throughput DNA construction pipeline, at the same pushing the limits of DNA assembly capabilities. They will also work closely with Asimov's Synthetic Biology, High Throughput and Cell Line Development teams. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the foundation for engineering biology. About the Role: Conduct PCR, Golden Gate or Gibson Assembly, plasmid purification, and sequencing prep to validate DNA constructs, both manually and in high-throughput using liquid handlers (e.g., Echo, Bravo, Hamilton STAR) following Standard Operation Procedures (SOPs) Contribute to vector assembly design, and remediation plans. Work with your manager to generate regulatory reports to support our customers' needs. Maintain accurate sample tracking and documentation in LIMS to ensure data integrity and reproducibility. Assist with large-scale plasmid preparations (LSPs) to support internal and external projects. Collaborate with scientists and other RAs to troubleshoot workflows, improve efficiency and develop new initiatives within the team. Work as part of a multifunctional team, you'll partner with synthetic biologists on the DNASC team as well as members of the Cell Line Development, Synthetic Biology and Software Development teams. About You: You have a B.S. or M.S. degree in biology, biochemistry, biological engineering, or a related field. Deep bench experience is necessary to be successful in this role, and you will have 3+ years of biopharma experience. You value teamwork and are motivated to contribute to the team's goals. Working as part of a highly integrated research team is exciting to you. Automation experience is a plus but a desire to learn to develop automation of lab experiments is a must. You will have independently or collaboratively designed an assembly plan to generate plasmids using either Gibson or Golden Gate. You have experience, outside of coursework, with modern molecular biology and/or microbiological techniques such as various DNA assembly methods (Golden Gate, Gibson), PCR, colony picking, and DNA preps. Being detail-oriented isn't just a sound bite for you, it's part of your DNA. Experience with optimizing cloning protocols (PCR, Gibson, and especially Golden Gate) and basic mammalian cell culture techniques is a plus. Experience extracting data using scripts from large databases or desire to learn is a plus. We're big on tools here! We're happy to train you but if you know your way around Benchling, LIMS, Google Drive, and Excel, it'll help you come up to speed quickly. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives. Compensation Range: $85K - $90K

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform-from cells to software-to enable the design and manufacture of next-generation therapeutics. What would software engineering be like without an IDE? How could humans design a modern plane without CAD? Genetic engineering will be even more demanding-and we're building the tools to make it possible. Kernel is our platform for bioengineers to design, build, and debug genetic systems as confidently as we ship code. We're looking for a Staff Software Engineer to help us build it. You'll join an interdisciplinary team that works directly with scientists, synthetic biologists, and computational biologists alongside your teammates in software engineering and product. About the Role: Make architectural decisions that will shape Kernel for years, with real ownership over how the system evolves. Design GraphQL APIs for searching, editing and analyzing tens of thousands of genetic constructs using Python 3, SQLAlchemy and Strawberry. Architect data models that represent the genuine complexity of biological systems. Interface directly with synthetic biologists to understand their workflows and identify tools that would transform their productivity. Be part of an on-call rotation to support the software you've helped develop. About You: You have 10+ years building production software - systems that other engineers depend on, not research code that runs once. You have deep expertise in Python 3, and ideally with GraphQL, SQLAlchemy, and/or Strawberry. You're the kind of engineer who loses track of time working on an interesting technical problem. You want challenges that will have you waking up with a new idea that you can't wait to try. You think about API design, data migrations, and what happens when the system has 10x usage. You want to help design a product with a close-knit team, not just write code from predefined specifications. You can navigate the ambiguity of building something first-of-its-kind. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

Job Description Our mission at Asimov is to radically advance humankind's ability to design living systems, enabling biotechnologies with societal benefit. We're developing a mammalian synthetic biology platform-from cells to software-to enable biotechnologies with outsized impact, with an initial focus on gene therapies, cell therapies, and protein therapeutics. We are seeking a strategic, hands-on Head of Finance to build and lead our finance and accounting function from the ground up. In this newly created role, and reporting to the Head of Commercial, you will establish core financial processes, ensure accurate revenue recognition, support budgeting and forecasting, while overseeing all accounts payable and receivable activities. This role offers the unique opportunity to design and optimize financial systems as a team of one within a rapidly growing biotech startup. The ideal candidate will thrive in a fast paced, collaborative environment while bringing financial rigor, process discipline, and forward-thinking leadership needed to support scientific innovation and fuel the company's next phase of growth. About the Role: Accounting & Controls: Ensure timely and accurate recording of revenue, COGS, and expenses across all product lines. Maintain reconciliations, accruals, and closing schedules. Audit & Compliance: Lead preparation for the annual audit, liaise with auditors on technical issues (e.g., revenue recognition, asset classification), and ensure compliance with tax and regulatory requirements. Budget Tracking: Monitor spend against budget, provide variance analyses, and maintain rolling forecasts with input from department leads. Systems & Processes: Recommend and implement scalable general ledger and procurement systems (e.g., Prendio or equivalents) to improve reporting, visibility, and spend control. Cash & Runway Visibility: Produce monthly cash flow reports, identify risks to runway, and flag required actions. Reporting: Prepare accurate and timely monthly/quarterly financial statements, management reports, and supporting schedules for leadership and investors. Payroll: Manage scalable payroll systems and processes, ensuring accuracy, timeliness, and compliance across multiple states, while partnering with HR to support an expanding and distributed workforce. Strategy: Serve as a strategic thought partner to leaders across the organization to align financial priorities with R&D, product, commercial and operations strategies. About You: You have a Bachelor's or Master's degree in Accounting or Finance with 10+ years of progressive experience in accounting/finance. CPA certification is strongly preferred. You have experience working in a high-growth company, in the life sciences, biotech, or tools/services industry, You have strong technical accounting expertise, including revenue recognition, COGS tracking, accruals, and GAAP compliance. You have experience with audits, tax compliance, and working directly with external auditors. You are proficient with general ledger systems, procurement platforms, and financial reporting tools. You've demonstrated the ability to build scalable accounting processes and internal controls in a high-growth company. You have an analytical mindset with attention to detail; able to identify variances, trends, and risks early. You have excellent communication skills, able to translate accounting into clear business insights. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives. Compensation Range: $170K - $200K

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We've built a mammalian synthetic biology platform - from cells to software - to enable the design and manufacture of next-generation therapeutics. We are seeking a Head of Cell Line Development (CLD) to lead Asimov's biologics CLD team and help push the boundaries of biologics manufacturing. The successful candidate will be responsible for managing direct reports and lab activities in support of the generation and characterization of cell lines expressing the highest quantity and quality of protein therapeutics. We have experienced rapid growth in both our project portfolio and CLD team, and we expect that growth trajectory to continue for the foreseeable future. This role will be central to scaling capabilities, workflows, and leadership structures accordingly. This role requires a strategic leader with a deep technical foundation in biologics cell line development and a proven track record of growing and managing high-performing teams. Working closely with Asimov's synthetic biology, process development, computational modeling, and software teams, this role will shape Asimov's CLD vision and contribute as a thought leader to advance the state of the art in biologics cell line development. The role will also partner with commercial, program management, and technical teams to support customer-facing communications, including scientific discussions with prospective clients and collaborators. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology company. About the Role: As the Head of CLD, you'll lead and develop Asimov's CLD team, managing scientists and research associates focused on CHO-based biologics CLD. You'll guide individuals and the team towards personal and professional development milestones, all in support of Asimov's vision and goals. You'll drive excellence in execution, ensuring robust, high-throughput workflows for stable clone generation, screening, and characterization to deliver production cell lines meeting titer, quality, and regulatory expectations. You'll address complex cell line development challenges by demonstrating and applying cross-functional knowledge and industry best practices. You'll foster cross-functional collaboration with Synthetic Biology, Process Development, Process Modeling, Computational Biology, and Software teams to integrate design, data, and automation capabilities. You'll serve as a scientific and technical thought leader, identifying and implementing emerging technologies in expression vector design, gene integration, host engineering, productivity optimization, and workflow improvements. You'll represent Asimov externally, contributing to industry conferences, industry forums such as AMBIC and BioPhorum, filing patents, and publishing peer-reviewed manuscripts. About You: You have a Ph.D. in Biological Engineering, Cell Biology, Molecular Biology, or a related field. You have 10+ years of experience in CHO-based cell line development supporting IND-enabling and/or GMP manufacturing activities. You have a deep understanding of cell biology, expression system design, gene integration technologies, and process-relevant analytics. You have a track record of strategic thinking and innovation, translating R&D advances into scalable, manufacturable platforms. You have proven experience managing a team of scientists, with a track record of developing scientists and supporting rigorous scientific execution. You are comfortable engaging with internal and external stakeholders and can clearly communicate scientific and strategic considerations to prospective partners or clients. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

Job Description Our mission at Asimov is to radically advance humankind's ability to design living systems. We're developing a mammalian synthetic biology platform-from cells to software-to enable biotechnologies with outsized impact, with an initial focus on gene therapies, cell therapies, and protein therapeutics. What would software engineering be like without an IDE? How could humans design a modern plane without CAD? Genetic engineering will be even more demanding-and we're building the tools to make it possible. Kernel is our platform for bioengineers to design, build, and debug genetic systems as confidently as we ship code. We're looking for a Senior Software Engineer to help us build it. You'll join an interdisciplinary team that works directly with scientists, synthetic biologists, and computational biologists alongside your teammates in software engineering and product. About the Role: Design GraphQL APIs for searching, editing and analyzing tens of thousands of genetic constructs using Python 3, SQLAlchemy and Strawberry. Shape the software architecture and be involved in the long-term product direction.Collaborate on data models that represent the genuine complexity of biological systems. Interface directly with synthetic biologists to understand their workflows and identify tools that would transform their productivity. Be part of an on-call rotation to support the software you've helped develop. About You: You have 6+ years building production software - systems that other engineers depend on, not research code that runs once. You have expertise in Python 3 and ideally experience with GraphQL, SQLAlchemy, and/or Strawberry. You're the kind of engineer who loses track of time working on an interesting technical problem. You want challenges that will have you waking up with a new idea that you can't wait to try. You want to help design a product with a close-knit team, not just write code from predefined specifications. You can navigate the ambiguity of building something first-of-its-kind. We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives. Compensation Range: $160K - $175K