Assay development scientist job description

We are looking for a highly-motivated Research Associate or Scientist to develop and conduct cellular and biochemical assays to evaluate potential therapeutics, both small and large molecules. Experience in ELISA assay development, cell culture, gene expression with RT-PCR and/or enzyme kinetics is desirable. The candidate needs to be proficient in assay design, trouble-shooting, data analysis and working with 96-w & 384-w plate-based assays. This position requires working with an interdisciplinary team within QDI as well as with outside collaborators.

Essential Duties & Responsibilities

List below the major areas of responsibility of the job in descending order of importance (most important to least important). Indicate the approximate percentage of time spent on each responsibility (note the total of all percentages must equal 100%, 3-5 responsibilities is normal but may vary). Under each responsibility, summarize the specific duties required to perform the job. Give as much detail as necessary to fully explain the job and consider:

• Whether the reason the job exists is to perform that function and whether removing the function would fundamentally change the job;
• Whether serious consequences would arise if someone in this job is not required to perform a particular function/s;

• The number of employees available to perform the function or among whom the function can be distributed; and,
• The degree of expertise or skill required to perform the function.

% of Time

Duties & Responsibilities

75%

Execute biological experiments.

5%

Design biological experiments.

10%

Analyze and interpret experimental data

10%

Interact with team members and clients

Choose %

Choose %

Choose %

100%

Minimum Job Requirements & Qualifications

Describe the minimum level of formal education and experience required to successfully perform the job
as well as any required certification, licensure or registration. KSAs may include language requirements, required computer ability, communications skills, etc.

Educational/Training Requirement:

For Research Associate: BS/MS in biology, biochemistry and other related fields

For Scientist: PhD in biology, biochemistry and other related

• Basic understanding and training in Biology, Biochemistry and any related field.
• Ability to design, execute, analyze and interpret experiments.
• Attention to detail.
• Excellent communication and organizational skills.
• Ability to follow through.
• Positive and collaborative disposition with the ability to work cooperatively within a team

Experience:

• Driven to successful outcomes, adaptive in times of change, and innovative in face of roadblocks

For Research Associate: 3+ years of hands-on experience, industrial experience is preferred.

For Scientist: 2+ years of hands-on experience, industrial experience is preferred.

Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.

Americans with Disabilities Act (ADA)
PHYSICAL DEMANDS and work environment CHECKLIST

PHYSICAL DEMANDS

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. These may include lifting, pushing, climbing, degree of eyestrain, sitting for extended periods of time, prolonged standing, etc. Frequency refers to the amount of time one is engaged in the activity; please estimate time by checking the appropriate boxes.

Physical Demands

Physical Demand

None

Rarely

Occasionally

Frequently

Constantly

Weight

Standing

X

Walking

X

Sitting

X

Lifting

X

Choose weight

Carrying

Choose weight

Pushing

Choose weight

Pulling

Choose weight

Climbing or balancing

X

Stooping, kneeling, crouching
or crawling

X

Reaching with hands/arms

X

Using hands to finger, handle, grasp or feel

Talking

X

Hearing

Tasting or smelling

X

ArsenalBio's mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer. Our products are being designed to herald the transition of adoptive cell therapy from a hospital based treatment to outpatient therapy, like most other cancer treatments.

We are seeking a talented and motivated Scientist to join the ArsenalBio Technical Operations team. The individual will work closely with team members to develop analytical test methods and characterization tools in support of our cell therapy products. The individual will also interact cross-functionally across the organization to enable the success of ArsenalBio.

What You Will Do:Design, test, and implement fit-for-purpose analytical assays to support the characterization and release of cell therapy products.Independently develop ELISA and cell-based assay and qualify assays Plan and execute assays, and analyze data and timely deliver reports Provide technical expertise and leadership within project teams and in a matrix environment.Establish tracking and trending analyses of process development and cGMP production runs, including evaluation of critical reagents and lot to lot variability, in order to improve process standardization.Good understanding of cGMP environment, for process and assay development, qualification and validation preferred.Collaborate closely with other functions to enable effective and successful project development; actively engage in cross-functional collaboration with peers to overcome challenges Organize, communicate, and present complex data sets to key stakeholders and senior management

What You Will Bring:Degree in Biotechnology, Bioprocess engineering, Immunology, Molecular Biology, Biochemistry, or a related discipline Years of relevant experience in biopharmaceutical setting, and successful performance track record in establishing and applying analytical assays for cell therapy products as stated: Scientist - Ph.D.with 0-2 years, or Masters degree with 5+ years industry experience, or Bachelors degree with 7+ years industry experience with several years of flow cytometry and other related skills preferred Expertise in ELISA and cell-based assay development Prior experience in T cell biology, cell therapy, industry, analytical development preferred Expertise in multi-color flow cytometry including panel design and data analysis, T cell functional assays (proliferation, cytotoxicity, cytokine/chemokine release), ELISA, and qPCR highly preferred Understanding of ICH guidelines, Quality by Design (QBD) principles, method qualification and validation preferred Ability to work in a highly adaptive environment and learn new skills for changing priorities Flexible and creative, with ability to think outside the box in order to problem solve Excellent communications and presentation skills, written and verbal Demonstrated ability to work in a highly collaborative team environment, coordinate tasks across multiple projects to meet deadlines Willingness to expand scope of responsibilities outside of initial job description, with time
What We Will Offer You:
ArsenalBio has a generous and comprehensive benefits package that includes but is not limited to medical, dental, and vision as well as mental health resources, virtual and telehealth options, coaching, infertility treatment, parental leave and health savings accounts. We also offer flexible work schedules and flexible time off, which includes two extra “Arsenal Days of Rest” every quarter for employees to recharge.

We have a robust mentorship program, and comprehensive development tools to help employees take control of their career paths and grow into their best selves. ArsenalBio believes in investing in the well-being of our employees - both at work and at home, as they are our greatest asset. They bring scientific talents in molecular biology, immunology, pharmacology, protein chemistry, computational biology, automation, genome engineering, software and other fields to make the future happen now.

ArsenalBio prioritizes the providing of a safe and healthy workplace that is consistent with COVID-19 public health guidance and legal requirements. In order to protect our employees and visitors, we require all visitors (including candidates) and employees to present proof of being fully vaccinated against COVID-19 when coming onsite.

We are committed to hiring the best talent from diverse backgrounds. A diverse workforce engenders richness of thought, creativity and discovery. We invite individuals who embrace intellectual achievement to bring their unique personal and professional journeys and together we will build transformative cell therapies for cancer patients.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

To all recruitment agencies: ArsenalBio does not accept agency resumes. Please do not forward resumes to our jobs alias, or ArsenalBio employees. ArsenalBio is not responsible for any fees related to unsolicited resumes.

Insmed is a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion.

Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves. If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career.
Named Science's 2021 Top Employer

Insmed is dedicated to creating a collaborative environment where our team can thrive. Every day, our employees turn their passion for science and research into innovative solutions for patients. That's why we were named the No. 1 company to work for in the biopharma industry in Science's 2021 Top Employers Survey.

A Certified Great Place to Work

We believe our company is truly special, and our employees agree. In July 2022, we became Great Place to Work-certified in the U.S. for the second year in a row. In 2022, we were also listed as the No. 2 company on the Best Workplaces in Biopharma™ List, Small and Medium, and one of the Best Workplaces in New York™️️, which recognizes companies headquartered in NY, NJ, and CT.

Insmed San Diego is seeking a research Scientist. This individual will design assays and execute experiments demonstrating the potency of therapeutic molecules. This individual will be responsible for identifying and implementing new technologies to study signal transduction and biochemical assays related to therapeutic constructs in relevant cell systems. Individual will be responsible for establishing novel cell culture systems to evaluate DNA, RNA and protein expression as well as functional readouts related to these constructs.

Additional representative responsibilities will include, but not necessarily be limited to, the following:

• Establish novel cell culture systems

• Implement technology for studying signal transduction of therapeutic compounds in cellular systems

• Develop cell-based potency assays for novel therapeutics

• Document results and present to scientific leadership of the company

• Develop assay transfer protocols and work with analytical development and QC groups on assays

+ PhD in biology, cell and molecular biology or related field

+ Experience in a relevant lab performing cellular, biochemical, and molecular assays

+ Significant disease-area knowledge as related to Insmed programs

+ Demonstrated technical ability in cell culture, in vivo and ex vivo model systems, high content screening, capillary electrophoresis and western blotting

+ Entrepreneurial spirit, with strong willingness to take on new challenges required to bring novel medicines to the clinic.

+ Strict adherence to environmental, health, and safety guidelines.

Up to 5% travel, both domestic and/or international

Insmed Incorporated is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

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