Biochemical engineer job description

•Manage and oversee analytical activities performed in-house and at contract sites associated with method development, qualification/validation, transfer and drug product qualification for production and quality specifications.

•Calibrate and operate BGA (Rapid lab 1260), ViCell, Nova Flex 1, Nova Flex2, Bio HT and advanced Osmometer equipment.

•Apply advanced scientific principles and concepts to a broad range of research problems and develop innovative analytical solutions related to drug products in compliance with appropriate SOPs and regulatory guidelines.
•Monitor and report progress of project deliverables within agreed project timelines.

•Coordinate with other groups and activities necessary to ensure deliverables are met.

•Assure all laboratory documentation and other regulatory compliance systems are maintained according to regulatory standards.

•Author/review and edit key documents such as SOPs for analytical test methods, study protocols, reports, training materials, relevant sections of regulatory filings and deficiency requirements and responses.

•Develop and revise documents with suitable terminology, content and format to ensure compliance with site guidelines on analytical equipment.

•Maintain control of documentation, including accurate document history and change revision.

•Periodically review SOPs, forms and other GMP-related documents and facilitate Corrective and Preventative Actions (CAPA).

•Maintain QMS trainings to ensure regulatory compliance and in according to internal SOPs.


Qualifications


The Ideal Candidate Possesses:

Experience with analytical methodologies to characterize drug substances for raw materials, in-process and finished products. Experience in calibrating and operating BGA (Rapid lab 1260), ViCell, Nova Flex 1, Nova Flex 2, Bio HT and advanced Osmometer equipment. Ability to adapt to shifting priorities, change, stressors and to find appropriate balance between needs of the organization, others and self

Minimum Qualifications

BS in Chemical/Biochemical Engineering/Biological Sciences or related discipline with 3 - 4 years' relevant industry experience in upstream process development or MS + 1 - 2 years' experience. Prior analytical experience. Ability to effectively proofread documents to ensure accuracy. Active listening skills. Ability to translate verbal guidance into precise operating instructions on analytical equipment. Strong organizational and communication skills. Team based collaborative problem solving. Strong understanding of cGMP, Data Integrity and ALCOA principles. Authorization to work in the United States indefinitely without restriction or sponsorship.



Additional Information


Position is full-time, Monday - Friday 8:00am - 5:00pm. Candidates currently living within a commutable distance of Framingham, MA are encouraged to apply. Excellent full time benefits including comprehensive medical coverage, dental, and vision options.

Life and disability insurance 401(k) with company match Paid vacation and holidays



Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.


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Notable acknowledgments:

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This position is open to candidates authorized to work in the United States on a full-time basis for any employer. LanzaTech is an Equal Employment Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status.

Position Summary:

We have an exciting opportunity for a Chemical Engineer/Biochemical Engineer to join the Strain Development team at LanzaTech. The candidate will utilize state-of-the-art cultivation and systems biology approaches to characterize the physiology of novel Clostridium autoethanogenum strains under a range of conditions. The role also involves employing engineering principles to use and further develop down-scale controlled gas fermentations that bridge scale gaps between bench and pilot scales. The successful candidate will contribute to concept development and process parameter optimization for bench-scale bioreactors. As a member of this team the successful candidate will operate gas fermentation reactors and supporting systems, participate in experimental planning, and join cross-functional team-based projects with engineering, fermentation, synthetic biology, and computational biology. This person will be expected to design and execute laboratory experiments, analyze quantitative and systems biology data, to write and communicate results to understand and improve microbial fuel and chemical production. The successful candidate will work in close collaboration with the synthetic biology team that uses genetic manipulation, physiological characterization, high-throughput studies for strain generation, in conjunction with computational biology experts and ultimately with the Process Integration team on pilot activities.

Specific Job Functions:

Fermentation operation

• Operate and troubleshoot lab scale fermentation reactors.

• Apply engineering principles and concepts to demonstrate the mass transfer and transport phenomenon properties of gas fermentation system.
• Design experiments around fermentation process operating parameters and formulate correlations between process variable and productivity.
• Aid in development and operation of novel lab-scale gas fermentation processes that emulate pilot scale operations.
• Write up novel concepts as invention disclosures and participate in the patent application process.

Systems biology

• Apply systems biology tools and machine learning methods to identify high value science for characterization and for predictive biology applications.
• Integrate numerous biological datasets and analysis tools on collaborative projects to generate and test hypotheses about biological functions and interactions.
• Contribute to a unified, extensible system in collaboration with computational biology team members.

Minimum Qualifications:

• Master’s degree in Chemical Engineering with a biology focus (bioprocess, biochemical, biological), fermentation science or a related field.
• Proven ability to perform independent research and organize data for publication and presentations.
• Demonstrated ability to interact effectively with technical and scientific staff.
• Ability to work independently and in a team environment.
• Demonstrated ingenuity in dealing with complex problems.
• Demonstrated strength and efficiency in technical writing.

Desired:

• Ph.D. Chemical Engineering with a biology focus (bioprocess, biochemical, biological), fermentation science or a related field.
• Experience with systems biology analysis (e.g. RNA-Seq, proteomics, metabolomics) and background in programming, data science and/or computational biology.
• Anaerobic microbiology experience.
• Knowledge or experience of gas fermentation technology by anaerobic acetogens.
• Practical mechanical experience with bioprocess equipment.
• Knowledge of analytics & instrumentation of biological processes.

Location

• LanzaTech Headquarters
• Skokie, IL USA

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