Bioinformatics scientist job description

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome - one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.

We are hiring a Principal Bioinformatics Scientist for the Applications Group to join our growing team. The charter for Nautilus's Applications Group is to use the insights generated by our platform to answer a broad set of biological questions with relevance to current scientific areas of focus, and in the process to establish strategic partnerships with biotechnology companies and research institutions that are actively investigating those questions. More broadly, we intend this work to drastically accelerate the rate of biological discoveries driven by proteomics. The person stepping into this role will need to leverage their expertise in biology, computational approaches, and the Nautilus platform in order to provide technical leadership for all of our Applications-supporting bioinformatics efforts.

This position will report to the Senior Director of Bioinformatics and Software Engineering and is located in San Carlos, CA, San Diego, CA, or Seattle, WA. A minimum of three days in office, preferred.

ResponsibilitiesWork cross-functionally with representatives of other teams - such as biologists, biochemists, hardware engineers, software engineers, and computational biologists -to define and execute the Applications-supporting bioinformatics plan Help us form partnerships with external organizations and, in tandem with other leaders within the business, set the strategy for how we answer meaningful biological questions within the context of these partnerships Provide direct technical contributions as appropriate to the Applications bioinformatics team's strengths and gaps

Requirements8-10 years of relevant experience supporting bioinformatic analyses in high performing research organization(s) is required 4 or more years of experience in a bioinformatics leadership role is required A PhD degree in biology, computational biology or similar related field is required You have an excellent track record of leading complex bioinformatics projects throughout all stages, from inception to results publication You are familiar with the strong points, limitations, and outputs of existing proteomic technologies You are comfortable with applying statistical analysis and visualization approaches to surface insights within raw, not-yet-cleaned biological data, and have built automated end-to-end data processing pipelines that deliver actionable results to scientists You are fluent in a variety of programming languages, frameworks, and tools - we are currently heavily invested in Python You have strong organization and communication skills with the ability to lead directly as well as through collaboration and influence You have fun when building complex systems while working side-by-side with experts from a variety of disciplines
Nautilus Team Culture

We are curious go-getters: this is a team of life-long learners who aren't afraid to tackle the big challenges while continuously pushing ourselves forward

We are detail oriented: we do great science by working smart and with diligence, and by learning from our mistakes

We are easy to work with: we want our workplace to be one where everyone can share their perspective and be treated with respect and kindness

CAMRIS is a clinical and life sciences firm that realizes innovative solutions to challenges worldwide through high-quality, cost-effective program and research management services. We combine our proven systems with today's most effective, evidence-based best practices to improve the lives of people around the world. Our core practice areas include HIV/AIDS, microbiology and infectious disease research, vaccine research, development and production, global health security, biodefense, and clinical research.

CAMRIS attracts the next generation of scientists to work at premier government research and development institutions with state-of-the-art facilities and equipment, under world leaders in health research. Our exceptional benefits package that includes medical, dental and vision coverage, 401k plan with employer contribution, paid holidays, vacation, Medical and Flexible Spending Accounts, and life insurance. If you enjoy being a part of a high performing health and research organization dedicated to making the world a healthier place, please apply today!

We are seeking a Bioinformatics Scientist to provide services in support of the PREMISE (Pandemic Repository through Microbial and Immune Surveillance and Epidemiology).
Responsibilities
• Develop and maintain bioinformatics pipelines for various genomics applications.
• Develop web-based in-house database interface.
• Implement and utilize workflows for next generation sequencing (i.e., QC and analysis).
• Participate in innovation and development of analytical solutions.
• Work collaboratively with multi-disciplinary team.
Qualifications
• BA/BSc with 4+ years of experience or MA/MSc with 2+ years of experience.
• Experience must be from a related field (i.e., Bioinformatics, Molecular Biology,
Computer Science, or related discipline) • Programming experience using relevant packages (i.e., Python, Perl, R)
• Detailed understanding of Illumina based NGS methods and tools
• Experience troubleshooting and exploring various existing scientific analysis tools
• HPC clusters and use of command line tools and scripting experience
• Working knowledge of existing tools to analyze NGS data
• Experience with relational database design and maintenance (i.e., MySQL, Postgres) is a plus
CAMRIS International LLC offers competitive salaries and comprehensive benefits. Please submit your resume online at www.CAMRIS.com . CAMRIS is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status, disability status, or any other characteristic protected by any applicable federal, state, or local law.
Full vaccination against COVID-19, defined as two doses of Moderna, two doses of Pfizer, or one dose of Johnson & Johnson's Janssen, is required for this position.

The Molecular Profiling and Data Science Department is looking for an enthusiastic and motivated Computational Scientist who values independent research in an open and collaborative working environment. You will participate in original studies that span from basic research to translation studies, directly impacting the lives of patients. You will also have the opportunity to develop novel computational methods from internal and external big data resources. You will join a diverse and inspiring team which cultivates discussion across scientists of differing backgrounds at the exciting intersection of genomics, technology development, machine learning, and immuno-oncology. We work closely with biological researchers from different scientific functions, especially the departments of Immunology and Inflammation, Oncology and Angiogenesis, Infectious Disease, and Precision Medicine, to address critical scientific questions.
In this role, a typical day might include the following:

Lead computational efforts in the Immuno-Oncology (IO) field by developing or applying innovative methods from single cell genomics, epigenomics, spatial transcriptomics and other sequencing technologies. Discuss and analyze immuno-therapeutic strategies such as vaccines and antibody blockade. Work in concert with oncology pre-clinical and clinical teams to design next-generation sequencing experiments, draft data analysis plans, and provide critical analytics support. Prepare presentations and documentations for collaborators and senior management. Publish and present novel findings in peer-reviewed journals and conferences. Contribute to our team efforts in formulating analytical pipelines and benchmarked standards.


This job might be for you if:

You are passionate about understanding and applying efficient computational techniques to address biological questions. Bring innovative thinking to multi-omics data analysis. Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward within Regeneron. Can effectively communicate with collaborators with various backgrounds. Value teamwork and team excellence.


To be considered for this role, you must have a PhD degree in Computational Biology, Systems Biology, Quantitative Biology, Bioinformatics, Computer Science, Applied Mathematics, or related quantitative field. Experience with conducting bioinformatics analysis (e.g. single cell RNA-seq, ATAC-seq, bulk transcriptomic analysis). Strong background (2+ years preferred) in at least in one of the following scripting languages: R, Python, MATLAB. Experience working with single cell analysis tools such as Seurat, Scanpy, etc. Experience working with clinical samples is a plus. Familiarity in working in a Linux environment, shell scripting and Jupyter Notebook environment. Experience with public transcriptomics database such as human cell atlas, mouse cell atlas, and TCGA is preferable. Experience with cloud-based big-data analytics and machine learning to develop predictive models of immunotherapy response is highly valued.


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Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.