C4 Therapeutics Leadership

• Internationally Recognized Scientist: Quantitative biochemist with extensive pharmaceutical drug discovery/development experience. Strong publication record in high impact scientific journals. Elected to lead and speak at internationally recognized technical conferences (GRC, Keystone Symposia) and leadership positions in professional societies (ACS, Protein Society). Technical mastery of detailed target characterization using enzymology, biochemistry and biophysical quantification of ligand:target interactions. Specialist expertise in Infectious Diseases research.

• Proven Track Record of Project Delivery: Led multiple major antibacterial research programs involving multi-disciplinary project teams that delivered several Pre-Clinical Candidates that have progressed through Phase I clinical trials. Broad experience in leading early drug discovery efforts (assay development, High throughput biochemistry, Hit to Lead Identification).

• Skilled Strategic Global Leader: Demonstrated ability to solve complex communication and cultural gaps as evidenced by a successful professional secondment at the UK AZ high throughput screening group. Have overseen a large number (|10) of academic and industrial collaborations to access emerging science and innovation. Frequent involvement in due diligence activities on in-licensing opportunities; several have resulted in significant investment decisions. Regularly involved in cross-functional and geographical resourcing decisions to ensure maximal impact of global functions. Experienced in working with global external CROs to deliver routine and specialty project data.

• Accomplished Scientific Talent Manager: Successfully recruited, developed and retained an industry-leading Infection Bioscience department.

Specialties: Enzymology, Biochemistry, Biophysics, Infectious diseases, Assay Development, residence time

Adam Crystal is a Chief Medical Officer at C4 Therapeutics. He works or has worked at Novartis Institutes for Biomedical Rsch Inc. Adam studied at University of Pennsylvania.