California jobs in San Francisco, CA - 32 jobs

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science, academic and industry partners, and vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: Calico is seeking an accomplished Director of Analytical Chemistry to lead our small-molecule analytical development function. This leader will play a pivotal role in advancing Calico's development portfolio, supporting programs from pre-IND through commercialization. The ideal candidate will have deep expertise in designing phase-appropriate analytical methods, shaping analytical regulatory strategies, and driving comprehensive lifecycle management. Key Responsibilities: * Expertise with developing analytical techniques and specifications for immediate release oral solid dosage, extended-release oral solid dosage, parenteral, and subcutaneous delivered products * Oversee characterization and control strategies for drug substances and drug products in alignment with ICH guidelines and global regulatory expectations * Serve as the analytical lead on CMC teams, actively contribute to regulatory filings, and act as an SME for health authority questions * Lead quality control function of GMP drug substance and drug product testing * Design stability studies, interpret data, and support shelf-life justifications and post-approval changes * Collaborate cross-functionally with formulation, chemical development, quality assurance, and regulatory teams to ensure alignment and program success * Manage external contract analytical resources to ensure high-quality and timely deliverables * Develop and implement phase-appropriate analytical strategies and quality control methods * Represent the company in regulatory meetings and inspections as an analytical subject matter expert Position Requirements: * PhD in Analytical Chemistry or a related field * Minimum 15 years of industry experience in analytical development of small molecule pharmaceuticals * Proven track record in regulatory submissions (NDA, MAA) and supporting global filings and inspections * Deep knowledge of ICH, USP, and other relevant regulatory guidelines * Expertise in a wide range of analytical techniques including HPLC, GC, dissolution, spectroscopy, particle characterization, and solid-state analysis * Experience with Quality by Design (QbD) principles and risk-based analytical development * Familiarity with analytical support for combination products or novel delivery systems * Experience managing external partners and driving CDMO performance * Strong leadership, organizational, and communication skills * Ability to thrive in a fast-paced, collaborative, and dynamic environment * Experience with development of analytical methods for biologics is a major plus * Must be willing to work onsite at least 4 days a week The estimated base salary range for this role is $270,000 - $286,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Who We are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: Calico is seeking an experienced Process Chemist to join our laboratory-based chemical development team. The ideal candidate brings extensive hands-on experience in process research, route scouting, and scale-up of organic molecules. In this role, you will design, optimize, and execute synthetic processes that enable efficient, safe, and scalable manufacturing of small-molecule intermediates and APIs. This is a lab-focused position requiring strong experimental skills, deep organic chemistry knowledge, and the ability to translate laboratory findings into robust processes. Key Responsibilities: * Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates * Perform laboratory experiments to improve yields, selectivity, throughput, and impurity control * Conduct detailed reaction analysis using, HPLC, GC, LC-MS, and other analytical techniques * Perform impurity identification and synthesis * Identify and mitigate process risks related to safety, scalability, and robustness * Collaborate with cross-functional partners including analytical chemistry, formulations, and quality assurance * Prepare clear, data-driven reports and present experimental results to project teams * Support technology transfer to contract manufacturing organizations, including review of master batch records and process descriptions * Maintain accurate lab documentation and adhere to all safety and compliance standards Position Requirements: * M.S. in Organic Chemistry or related field with 14+ years of relevant industrial experience in process chemistry * Strong expertise in synthetic organic chemistry and reaction mechanism fundamentals * Demonstrated success in developing scalable synthetic processes * Proficiency with standard analytical instruments and data interpretation * Excellent problem-solving, organization, and communication skills * Ability to work independently while contributing effectively to a team environment * Familiarity with cGMP and ICH guidelines * Strong attention to detail and a commitment to high-quality experimentation * Ability to manage multiple projects and shifting priorities * A proactive, collaborative mindset with enthusiasm for process improvement * Must be willing to work onsite 5 days a week The estimated base salary range for this role is $163,000 - $201,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: Our mission in HR is to promote a culture and community where people can innovate, collaborate and develop. The People Advisor (PA) role partners with our leaders and client groups and collaborates with our HR Centers of Excellence (Staffing, Total Rewards, HR Operations and Learning and Organization Development) to implement and coordinate Calico's various HR programs and processes, including recruiting great people, providing competitive and inspiring total rewards, fostering a values-based culture, implementing straightforward processes and systems and offering learning and development programs tailored to our unique needs. The PA partners with senior managers to anticipate and address individual, team and organizational needs and works to develop solutions through cultural and process perspective organizational development. The PA is viewed as a strategic partner, change agent, and member of the line management staff. HR provides value to the business through influencing analysis and decision-making around organizational strategy, leadership, talent management and development, succession planning, team effectiveness, change management, workforce planning, organization development and design, performance management, employee engagement, employee relations and organizational communications. The PA builds relationships with specific business and scientific leaders to determine their organization's people-related needs and collaborates with the HR Centers of Excellence to bring the most effective processes, programs and solutions to our workforce. We are seeking a People Advisor to partner with our Research & Development organizations. The ideal candidate will contribute at strategic levels to bring creative and actionable ideas and solutions to a growing organization. This person should have strong business acumen combined with a proven ability to align business needs with HR solutions to move the organization forward. We currently have about 135 people in our Research and Development teams. Position Responsibilities: Diagnose Organizational Needs * Develop a deep knowledge of client groups and their needs through regular engagement with leaders and their teams * Use their knowledge of business and Human Resources insights, metrics, expertise, and decision principles to effectively diagnose topics with a wide range of complexity * Diagnose root causes of work environment issues, disruptive team dynamics, and ineffective organizational setups Recommend Organizational Interventions * Provide thought leadership and guidance to managers on organizational design and organization development matters (e.g., reorganizations, building organization capability, strategic workforce planning) * Initiate interventions and shape solutions in collaboration and co-creation with key stakeholders * Proactively assess team and manager development needs, make recommendations, and implement appropriate solutions Implement HR Processes * Serve as a creative partner and "delivery arm" to your client groups for HR processes designed and run by the HR Centers of Excellence, include performance management, promotions, development planning, compensation planning, onboarding, offboarding, and performance improvement * Advise hiring managers on headcount planning, role scoping and search strategy in collaboration with Staffing Partners * Provide employee relations interventions as needed in close collaboration with direct managers and leaders Coach Leaders and Managers * Coach and advise leaders in an effort to make them self-sufficient as strong managers and leaders in areas such as leadership team effectiveness, organizational planning, change management, team leadership, organizational leadership, talent management and general management issues Advise on People Strategy * Support senior management in translating company mission and goals into sustainable people and organizational strategies, programs, practices and behaviors * Advise executives on how to align manager and employee capabilities to the mid- to-long-term business needs Address People and Organizational Challenges * Consult with leaders to help them navigate through employee issues so they understand the risks and benefits of different scenarios to make the best decisions for the organization * Mediate and help resolve complex employee relations issues Design and Implement HR Processes, Interventions, and Solutions * Gather and analyze internal and external data and share insights with leaders in order to make critical decisions and recommend innovative solutions * Integrate and partner with fellow PAs and colleagues in the HR Centers of Excellence to implement solutions and help scale the organization * Facilitate team and offsite meetings as needed * Participate as an integral member of the extended HR Big Bets community Position Requirements: * 10+ years of progressive HR experience, with 5+ years in an HRBP role or equivalent role; management consulting experience a plus * Biotech/Pharma experience * Experience supporting research scientists preferably in an industry setting and/or experience supporting drug development sub-functions and team members * State and Federal employment law knowledge * HRIS experience * Inspired by Calico's mission and business model * Experience working with scientist leaders and managers * Demonstrated competence in a variety of HR functional areas including, but not limited to, coaching, employee relations, compensation, performance management, and program management * A "roll up your sleeves and get it done" work style * Good judgment and discretion; the ability to maintain confidentiality * The ability to engage, inspire, and influence people across diverse groups and levels * Excellent verbal and written communication skills * Project management and change management experience * Humility and an ability and willingness to work cross-functionally at all levels * A demonstrated consultative approach where you see the business leaders as your clients whom you partner with to build solutions * Committed to building a diverse and inclusive work culture and fostering psychological safety and a strong sense of belonging * Enterprise mindset and system thinking, proven ability to work effectively across multiple functional areas, and networks in a fast-paced environment * Influencing skills to build trust with individuals at all levels within the organization * Must be willing to work onsite at least 4 days a week The estimated base salary range for this role is $250,000 - $305,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: The Systems Administrator is a member of Calico's Information Technology team and manages physical and virtual servers, data storage, compute clusters, and cloud infrastructure used by Calico scientists. This position works closely with scientists who are leaders in their fields, advising and assisting them with their data science and high-performance computing needs. We are seeking a resourceful individual with expertise in a variety of system administration functional areas who enjoy delivering high performance computing and data solutions to a dynamic, creative research and development organization. Responsibilities: * Provision, monitor, and support Calico's on-premises and cloud-based high performance computing clusters, storage, virtual machines, and projects * Diagnose, isolate, and resolve complex application and system technical problems * Implement and document system architectures, new capabilities, and operational standards * Participate in the design and maintenance of Calico's cloud environment for data science and research computing * Support technology evaluations and assessments * Work in cooperation with Calico technology partners, including Google Enterprise Network, Google Professional Services, sponsored research partners, and Contract Research Organizations Position Requirements: * 3+ year Linux system administration experience * Familiarity with common computer hardware: DIMMs, disks, networking * Shell scripting and basic utility programming (e.g. Python) expertise * Ability to provision cloud resources using scripts, APIs, and deployment managers * Passion for providing excellent customer service and enthusiasm to assist scientific software developers and data scientists * Curiosity and interest to acquire knowledge in cloud computing and biotechnology topics, methods, and applications * Self-motivated and able to work without close supervision * Must be willing to work onsite at least 4 days a week Nice to Have: * Expertise in two or more of the following areas: * Google Cloud Platform console, cloud services, security policies, and permissions * Deploying and managing virtual machines, managed databases, and services on a major cloud platform (e.g., AWS, Azure, GCP) * Docker/Kubernetes cluster deployment and administration * CI/CD management, automation scripts experience with tools (e.g., bash scripting, PowerShell, Terraform, Ansible, Salt, Chef, Puppet, etc.) * Source repository administration (e.g., Git, SVN) * Compute cluster provisioning (e.g., Bright Cluster Manager) and resource management (e.g., SLURM) * Installation and configuration of system management, monitoring/alerting tools (e.g., Nagios, Prometheus, Zabbix) * Directory and naming services management (Active Directory, LDAP, DNS) * Complex performance analysis including system processes, I/O subsystems, networks and other related components * Bare metal server provisioning, lifecycle management, and hardware troubleshooting (e.g., PXE boot, automated OS installation, firmware/BIOS management, RAID configuration, out-of-band management such as iLO/iDRAC/BMC) * NFS (OpenZFS) and Samba network storage management * Cluster file systems (e.g. Ceph, Lustre) * Life cycle data management for business continuance, disaster recovery and archive * Common data science and machine learning algorithms in platforms such as Python or R * Biotechnology methods and applications * Securing and managing Protected Health Information, Personally Identifiable Information (e.g, db GaP or PHI datasets) The estimated base salary range for this role is $137,000 - $169,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position description: Calico is seeking an intern to join the Protein Science group. We are looking for a highly motivated, detailed-oriented, organized team player who is comfortable working on complex problems. The intern will work on the structural and functional characterization of proteins. The successful candidate will work with other members of the Protein Science team and collaborate with other groups at Calico to provide mechanistic insight into proteins of interest. The internship will provide the intern with valuable experience in scientific discovery in an industry setting. Responsibilities: * Express and purify recombinant proteins * Play an active role in structural determination and assessment of protein-protein and protein-ligand interactions * Perform and optimize protein activity and/or binding assays * Communicate scientific results in a group setting Position requirements: * Currently pursuing a BS degree in biology, biochemistry, biological sciences or related field * Experience working with recombinant proteins (expression in E. coli and mammalian systems, multi-step-purification, analysis, and structural determination) * Knowledge of general principles of molecular biology and protein biochemistry * A strong interest in protein biochemistry * Detail-oriented and organized * Strong teamwork and communication skills * Self-motivated with a "can-do" attitude * Flexible, able to respond quickly to shifting priorities and able to multitask About our Program: Calico's internship program is a paid 12-week program over the summer for students interested in understanding the fundamental science of aging and finding treatments for the associated and intractable diseases. Working in a collaborative environment and fully embedded in one of our labs/teams, Calico interns tackle a unique project under the mentorship of at least one of our scientists or engineers. Program Features: * 3-month summer timeline * In-person experience at our offices in South San Francisco * Matching with at least one Calico mentor * Group supplemental activities weekly featuring guest speakers, Senior Leadership spotlights, and discussion groups on aging science, our drug development approach, and more * End-of-summer company-wide project showcase and poster session * Competitive compensation ($45 - $70/hour) and monthly living expenses stipend Nice to have: * Familiarity with experimental structural biology techniques * Prior experience with protein binding or functional assays would be helpful as would experience using an electronic notebook (such as Benchling), online registries (UniProt, NCBI, Protein Data Bank), and using software to design DNA plasmids (SnapGene) and to analyze protein structures (PyMol or ChimeraX) Program Eligibility: * Able to work in-person at our offices in South San Francisco * Free for a consecutive period of 11-12 weeks in June, July, and August * Not graduating before December 2026 * Exception for students enrolling into a graduate degree program in Fall 2026 * Must be enrolled in a US university * Must apply by application deadline: February 1, 2026.

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: We are seeking a Colony Lead to work in a dynamic team environment, reporting to our Director, Laboratory Animal Resources (LAR) Core. We are seeking a self-motivated individual who is detail-oriented, highly organized, flexible in a fast-paced environment with shifting priorities, capable of adopting new technologies, and has great time-management skills. The person will be responsible for the management of breeding colonies, veterinary care, study support, and assisting with the training program. Responsibilities: * Veterinary Care * Make recommendations as the Attending Veterinarian (AV) designee and perform clinical health assessments and treatments as described in SOPs and IACUC protocols * Observe health conditions of animals, recognize and report common signs of clinical illness and/or irregularities in animal behavior * Make recommendations on treatment based on established health protocols and approved protocols * Surgical or post-procedural observations and support for research staff * Aging colony observations and care under the direction of the AV * Execute colony health surveillance under the direction of the AV * Execute rodent quarantine program in collaboration with the VM and AV * Maintain colony health surveillance, quarantine, and environmental testing results * Breeding Colony Support * Assist in the maintenance of rodent colonies at the direction of Principal Investigator and Core labs * Record keeping: Maintain accurate breeding and health records database * Genotyping: Facilitate sample collection, submission, and processing with external vendors * Perform breeding colony tasks including, but not limited to, setting up matings, sexing, weaning and identification of mice; daily health/pregnancy checks, daily facility checks, cage changes, and sanitation * Provide rotational weekend/holiday coverage as needed * GEMS Procurement & Receiving * Coordinate and receive animal shipments from external GEMs lines, including management of colony data, confirmatory genotyping, and follow up on concerns/discrepancies * In-Vivo Study Support * Assist scientists and Core labs with their projects, which may include independently executing study support, assisting during technical procedures, clinical evaluations or behavioral assessments, performing necropsies or tissue collection, at the direction of research lab or AV * May perform dosing, blood collection, body weight collection in support of research projects * Document experimental data in technical notebooks or approved electronic files including activities undertaken, existing conditions, observed results and variation from expected data patterns * Training * Coordinate LAR team training events and update training records * Train husbandry and/or scientific staff in basic breeding techniques (sexing, weaning, genotyping, synched peak setups, pregnancy/plug checks), and in-vivo technical procedures related to genotyping and animal identification * Train husbandry staff on techniques related to colony health surveillance, weaning and sexing * May provide colony management software training to research staff * SOP & Protocols * Review or assist in the revision of SOPs and IACUC protocols * Perform all other related duties as assigned Position Requirements: * Bachelor's (B.S) or equivalent in animal or life science or related discipline * Minimum of 2 years of experience in the care, handling, and treatment of laboratory animals, including broad skills in husbandry and record-keeping * Experience in rodent colony health, clinical assessment, and veterinary interventions * Experience in the handling, management, and/or breeding of traditional and transgenic rodents * AALAS LAT certification or higher preferred * Attention to detail and accuracy in documentation * Strong written and verbal communication skills * Proficient with Google Suite, MS Suite, MacOS, PC Windows, and colony management software * Effectively collaborate with key support groups, core labs, and PI labs * Must be willing to work onsite 5 days a week The estimated base salary range for this role is $115,000 - $120,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

We are seeking a team coach for gymnastics competitive levels. This could be a part-time or full-time opportunity. You're going to love working here. Apply and meet the leadership team. Purpose: The purpose of a Team coach is to meet the needs and growth of the boy's competitive gymnastics teams. This person must be prepared to take charge of a team - leading a group of team members assigned. General responsibilities could also include recreational classes (where many team members come from), and "team development" classes (where our youngest team members come from), as well as student move ups and evaluations at CSC. Success is measured by each instructor's ability to gain smiles and skills from within their classes, build loyalty through active learning week after week, and measured progress of students up to the next level. Instructors teach with the support and guidance of an entire team of other coaches led by a Gymnastics Coordinator or Head Coach who are in charge of setting the standards of instruction for the programs. Excellent training toward higher levels is provided. CSC coaches also partner with site leadership to refine the customer experience - to the benefit of all students, parents, and each other. Hours per week: 15-25 - afternoons, evenings, and weekends. Plus competition travel. Pay: $18.45- $28.00 per hour. Commensurate with the background and experience of the applicant. Additional pay is available for session based competitions and travel as well as private lesson income. Qualifications: A background in child related services or youth sports coaching. Former competitive gymnastics and coaching experience is required with specific level history pending the position. Must be a high energy, positive and supportive person who is excited about working with kids of all ages and levels all the time. Training/Education: A condition of employment includes: CPR, First Aid certification within the first 30 days and an active and current “active” Professional Membership with USA Gymnastics. Skills: Excellent and proven communication and planning skills; leadership skills dealing with children; organizational skills, outgoing and energetic. A proven spotter on skills equal to the position assigned (L3-10) Duties: Teach/Coach kids!!! Spotting required of all skills commensurate with the levels required. Promote and demonstrate, safe and developmentally appropriate learning. Develop gymnasts at all levels with specific 4 event responsibility to assigned levels. Develop appropriate lesson plans designed for your group/level. Assist with equipment planning and safety, and general cleanliness. Communicate well and regularly with fellow employees, students, and parents on a regular basis. Maintain skill cards and charts (progress reports) for every student/group as assigned. Timely and professional - a constant interest in learning. Understand all CSC policies and procedures. Attend trainings as required. Review 'Team' documents annually. Other duties as assigned.

We believe gymnastics is one of the best foundations to have for kids to succeed in life - and it can be a lot of fun to teach. We are seeking part-time former gymnasts who want to share their experiences as instructors for boys gymnastics and our Ninja program. CSC is a great place to work with an unmatched energy and level of support to all its staff. Apply and find your next part-time job, or a possible lifetime career at CSC. You're going to love working here. Purpose: Provide school-aged children building blocks for success through the physical activity of gymnastics. Instructors are expected to bring professionalism, enthusiasm, safe practices, and their own unique strengths to their teaching, while following all guidelines as outlined in the Rec Instructor Handbook. CSC has a curriculum which must be incorporated into all lessons. Success in this position is measured by each instructor's ability to build their own classes, develop positive relationships with students and parents, and graduate students up to the next level. Instructors work for the Site Manager, and teach with the support and guidance of a Coordinator who is in charge of setting the standards of instruction for the programs. Instructors also implement and/or promote specific themes, skills, goals, projects, and events, as assigned. CSC Instructors also enthusiastically collaborate with site leadership to refine the customer experience - to the benefit of all students, parents, and staff. Ultimately, CSC's priorities define the position: To TEACH. To provide OUTSTANDING CUSTOMER SERVICE. To provide a SAFE AND HEALTHY ENVIRONMENT for all. To have FUN (and encourage others to have fun). Qualifications: A passion for working with children. Complete all ‘conditions of employment' for the position. Able to lift/assist athletes assigned (minimum 45 lbs.) Experience in child related services, or youth sports coaching is expected. Bonus = having a background as an athlete in competitive sports - especially gymnastics, or a proven background in teaching. General Skills: Leadership - Self-motivated, but also a team player. Confidently leads groups of children. Knowledge - Develops a strong understanding of beginner & intermediate gymnastics concepts. Utilizes appropriate skill progressions & development, and knows all associated terminology. Communication - Demonstrates strong communication skills with parents & students, fellow coaches, and CSC office staff & management. Hours per week: 2 - 30+ hours Wage: Minimum - $25.00 per hour

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: Calico is seeking an experienced Head of IT and Data Security & Privacy to lead and oversee all aspects of information security and data privacy, covering end-user computing and both on-premises and cloud infrastructure. This role requires over 15 years of experience in IT and technical management, a Bachelor's degree in computer science or a related field, and strong knowledge of information security practices, advanced Linux system administration, networking, hybrid cloud environments, and data lifecycle management. The ideal candidate will demonstrate outstanding technical leadership, strong people-management skills, and the ability to collaborate effectively with partners and senior management. Key Responsibilities: This position encompasses comprehensive oversight of information technology, data security, and privacy, including: * Leading and developing IT staff, establishing department goals, and managing the IT budget and expenses * Developing and enforcing best practices in IT, data privacy, and security across the organization * Defining and aligning IT strategies and processes with company-wide goals * Serving as the designated System Owner for regulated workflows * Overseeing on-premises and cloud computing infrastructure, including: * Identity management * Database administration * Infrastructure services * Enterprise architecture * Google Apps domain administration * Certificate management * IT facilities * Providing customer/end-user IT support * Managing networking and telephony, and audio/visual services * Ensuring compliance with privacy and export laws * Managing data privacy and security incident response * Developing and implementing privacy and security policies, training, and compliance programs * Implementing data security and data lifecycle management for business continuity, disaster recovery, and archiving * Managing relationships with IT vendors, contractors, and service providers * Acting as the primary Calico interface with Alphabet on IT matters (infrastructure, networking, security, data privacy) * Serving as the primary interface with external collaborators/partners on IT and privacy matters Position Requirements: * 15+ years' experience in IT and technical management * Bachelor's degree in computer science, information technology, or a related discipline * Specific technical proficiency requirements include: * Working knowledge of networking theory, technologies, and operations * Design and implementation of hybrid cloud environments/platforms for research computing * Operating knowledge of high-performance clusters, storage, and virtual machines * Directory and naming services management * Working knowledge of applications supporting clinical workflows * Advanced Linux system administration * Strong knowledge of information security practices and technology best practices * Oversight of: * Windows and mac OS endpoint management * Incident detection and response tools * End-user security training * Data lifecycle management for scientific data * Ability to provide outstanding technical leadership * Ability to work with leaders from partner organizations * Ability to build constructive and collaborative business relationships * Excellent presentation, written and verbal communication skills * Strong people-management and recruitment skills * Ability to handle multiple competing tasks in an orderly manner, prioritizing to ensure business deliverables are met * Must be willing to work onsite at least 4 days a week Nice to Have: * Experience in Biotech/Pharmaceutical industry * Experience with 21 CFR / GxP systems validation * Familiarity with applicable regulatory frameworks (e.g., GDPR, CCPA/CPRA, HIPAA) The estimated base salary range for this role is $295,000 - $309,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Founded in 1978, California Closets has built a reputation as the leader and design authority for custom-designed organizational solutions and exceptional service. We believe home is more than just a place - it should be a source of creativity, comfort, and connection. From beautiful walk-in closets and entertainment centers to versatile pantries and home offices, we design and install custom solutions for the whole home that add value to your life and home by making space for what belongs. Think of it as 'Practical Magic.' Job Description The Sales and Design Consultant role is critical to the California Closets Design Brand experience and the relationship earned with each and every customer. By listening to a customer's needs and collaborating on every detail, this role is responsible for delivering highly personalized, whole-home design solutions and exceptional service. Supported by enhanced training, this role requires passion for design, integrity, and commitment to excellence for measuring, designing, selling, and delivering custom solutions that add lifetime value and impact. This is a full-time (40 hours per week) position. What We Offer California Closets has both company-owned and franchise locations. This location is a franchise, therefore earns the following benefits: * A fun, creative, and inclusive work environment * 2 Compensation packages; Hourly plus bonus, or Outside Sales Commission plan. Average starting pay for a designers in their first year is between $45k-$50k. This includes a paid training program. * Health insurance - Medical, and Dental * Paid Vacation and Sick time * Simple IRA retirement plan with company match * Company phone number and mileage reimbursement Company-owned locations may offer different benefits. Duties and Responsibilities: * Commute to customers' homes and design custom storage solutions utilizing our proprietary CAD software program. * Meet or exceed monthly and annual sales targets * Bring in self generated leads. * Continuous follow-up with customers and collaboration with the installation team to ensure job completion. * Participate in meetings and training sessions. * Manage a portfolio of projects and clients of different complexity in a dynamic environment. Qualifications * Interior design education, direct industry experience, and/or in-home sales experience is preferred. * Advanced knowledge of Microsoft 365 and experience working with laptops, tablets, and other electronic devices is required. * Previous experience with CAD, or design software is preferred * The ability to be creative, yet meticulously detail-oriented with a sense of craftsmanship. * Valid driver's license and reliable transportation is required. Additional Information If your previous jobs do not show related work experience please provide a cover letter. We are an equal opportunity employer. All your information will be kept confidential. CA Privacy Policy - California Privacy Policy - California Closets Terms and Conditions: ***************************************************

Customer Experience - Greeter - for our San Jose locations Hours per week: This is a part-time position to start with an immediate needed Tuesday, Thursday and Friday afternoons and weekends. It may grow to up to 25 hours per week (multiple site assignments is possible) Qualifications: Experience in dealing with people - kids and adults - and interested and available specifically for our Cambrianna location. Hours can fluctuate pending the daily needs. Additional hours are available and may be assigned for coverage during special events and birthday parties held here at CSC. Training/Education: Must be at least 16 years of age. Training is provided. This position requires minimal experience in a previous customer service role. As a condition of employment this position requires an approved CPR/FA certification which, if the candidate is not currently in possession of, must be completed within the first 30 days of employment. Information is provided upon request and within the hiring process. Skills: Strong positive communication skills, outgoing, upbeat and professionally confident with customers, and staff, and must love kids. This is a sales position - learning all about dance and gymnastics, as well as our many events will be part of the training. Generally, our customer service staff are the front lines of greeting & helping our customers, maintaining a clean lobby and stocked/clean restrooms, decorating bulletin boards, opening/closing duties, and other duties as assigned. Duties: Sell our class programming - gymnastics, dance, and special events. Greet and assist all customers - especially new student tryouts Answer phones - correctly, professionally. Maintain clean and organized lobby areas and stocked / cleaned restrooms. Know and follow all CSC Policies and Procedures; read and understand pertinent handbooks. Complete New Hiring Training program/worksheet within 90 days (w/mentor) Attend scheduled orientation and trainings as required. Understand and complete the pricing and signup procedures with customers Collect payments Schedule "First Class" experiences with new students. Assist to Register new students Understand class records and roll sheets General office duties as assigned Assist in retail to maintain inventories Assist in the sales and support of events as assigned (including weekends) Assist with facility maintenance and cleanliness as required by management. Other duties as assigned. Pay Range: Minimum wage to $21.00 per hour pending the persons previous experience in customer service positions.

Oakland Port work opportunities 53' van and container experience preferred Work 50+ hours per week Compensation Benefits: Load Pay- Average Driver earns $80-85,000 per year (regional wage increase may apply) Includes Detention pay by the Hour ($25.00/hr) Health plans after 1st full month. Health Benefits are 90% employer Paid. Driver pays only $92.08/month for Medical, Dental & Vision health plans. Holidays, Paid Sick Leave/PTO after 90 days of service 401K w/ employer participation after 6 months. We match 6% of your contribution for a 12% savings rate. 80 hrs sick time after 90 days Contact Details: Contact: Rebekah Sellers Phone: ************** Class A CDL Driver (Oakland) - Load Pay - Average Driver earns $80-85,000 per year. Includes Detention pay by the Hour ($25.00/hr) Monday to Friday schedule most weeks TWIC Card REQUIRED Tanker (N) PREFERRED 6 months of driving experience required. Active Port experience Strongly Preferred 3 year MVR with no DUI convictions California Freight is seeking professional Class A CDL local drivers with TWIC card (Required). Home every night. Long-term, full-time positions available. Guaranteed 40 plus hours per week

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position description: Calico is seeking an intern to join the Automation Core team. To succeed, you will need to be an enthusiastic team player, detail-oriented, extremely organized and comfortable working on complex problems. In this position you will apply software engineering principles to real-world physical systems. You will move beyond simple scripting to help build the robust software tools that power our research, bridging the gap between code and robotic instruments. The successful candidate will work closely with members of the Automation Core and software engineering teams on developing Python APIs, improving test coverage, and prototyping tools that help our scientists run experiments more efficiently and reliably. Responsibilities: * Design and implement robust Python APIs to control complex lab systems (automated liquid handlers, robotic arms), turning physical actions into reliable software functions * Write automated tests (unit and integration) and hardware-in-the-loop validation protocols to ensure our software runs safely and consistently * Help build internal tools or simple web dashboards to monitor instrument status, visualize data, or run diagnostics * Collaborate with the team to integrate your code into shared frameworks, learning how to contribute to a larger, shared codebase Position requirements: * Currently pursuing a BS degree in Computer Science, Software Engineering, Robotics, or a related field * Strong proficiency in Python (familiarity with object-oriented programming is a plus) * Experience with Git/Version Control and a desire to write clean, readable code * Interest in the intersection of software and hardware - you are excited by the idea of your code moving a robot arm * Knowledge of basic biological concepts * Detail-oriented and organized * Strong teamwork and communication skills * Self-motivated with a "can-do" attitude * Flexible, able to respond quickly to shifting priorities and able to multitask Nice to have: * Experience in web development basics (e.g., React, Flask, or FastAPI) for building control interfaces * Experience with automated testing frameworks (e.g., PyTest) or CI/CD tools (e.g., GitHub Actions) * Experience in additional languages such as C# or Visual Basic/VBA About our Program: Calico's internship program is a paid 12-week program over the summer for students interested in understanding the fundamental science of aging and finding treatments for the associated and intractable diseases. Working in a collaborative environment and fully embedded in one of our labs/teams, Calico interns tackle a unique project under the mentorship of at least one of our scientists or engineers. Program Features: * 3-month summer timeline * In-person experience at our offices in South San Francisco * Matching with at least one Calico mentor * Group supplemental activities weekly featuring guest speakers, Senior Leadership spotlights, and discussion groups on aging science, our drug development approach, and more * End-of-summer company-wide project showcase and poster session * Competitive compensation ($45 - $70/hour) and monthly living expenses stipend Program Eligibility: * Able to work in-person at our offices in South San Francisco * Free for a consecutive period of 11-12 weeks in June, July, and August * Not graduating before December 2026 * Exception for students enrolling into a graduate degree program in Fall 2026 * Must be enrolled in a US university * Must apply by application deadline: February 1, 2026.

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: Calico is seeking a machine learning engineer to develop innovative machine learning algorithms to model and design proteins. This person will work with a team of dedicated experimental biologists to design experiments to test and iteratively refine machine learning predictions. The ideal candidate should be familiar with state-of-the-art machine learning techniques, including language/sequence modeling, representation learning, generative models, and self-supervised learning techniques. Candidates should have experience implementing, extending, and debugging state of the art machine learning models, and have expertise in designing and building robust data infrastructure and tools. Candidates should be independent, self-motivated and be expected to explore relevant ML literature and apply novel approaches to various protein design problems at Calico. Candidates must demonstrate a strong ability to communicate ideas and results through publications and presentations and be able to work cross-functionally to execute on complex projects. Position Requirements: * Ph.D. in Computer Science, Computational Biology, or related technical field; or M.S. in Computer Science, Computational Biology, or related technical field, plus 2+ years industry experience * Experience in applying deep learning to model biological sequences and structures * Expert in TensorFlow, PyTorch, and/or JAX * Strong software engineering skills and substantial expertise in Python * Track record of outstanding communication and collaboration in a cross-functional environment * Strong analytical and quantitative skills * Must be willing to work onsite at least four days a week Nice to Have: * Domain expertise in computational biology, biochemistry or structural biology * Familiarity with state of the art structure modeling tools such as AlphaFold * Public recognition in the field, e.g. via scientific publications or success in machine learning competitions * Prior experience working with biologists * Prior experience working as an ML Engineer/Scientist The estimated base salary range for this role is $170,000 - $233,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

This position entails working on multiple projects at one time as a member of functional and project related team efforts. Work is related to complex projects or a particular system or application that requires multiple areas of expertise. Accountable for the quality of own work, delivered within agreed procedures and timeframes and focused on internal and/or external customer needs. The role requires a good understanding of business applications and how to work with technical staff to understand problems with software and resolve them. Also required is a strong understanding of system development lifecycle methodologies as the projects assigned are driven by following project plans and general IT best practices. Primary Job Duties Researches, designs, develops and integrates applications at a senior-level as per written specifications. Write new software or make modifications to existing software applications and modules in accordance with written specifications. Develops software using disciplined software development processes, adhering to industry standards and software best practice guidelines. Essential day-to-day responsibilities include performing coding assignments, unit testing, ensuring development standards are being followed, analyzing functional specifications, producing technical specifications and unit testing scripts, and participating in team code reviews and impact assessments. Participate in project planning sessions with team members to analyze development requirements, provide design options, and provide work breakdown and estimates of work. Recommends solutions for software enhancements. Provide accurate and timely status reports on work progress. Other duties will include; Production support and subsequent defect research, assistance in technical and/or system documentation may be needed to aid support teams. Assist in development of software user manuals. Review work of peers and junior developers. Provides technical guidance and coaching to more junior team members. Qualifications / Requirements Bachelor's degree in Computer Science or equivalent required. (MS desired) 5+ years' development experience. Must Have Skills: Strong Web Content Management experience with Adobe AEM / CQ5 is a must. Experience with MarkLogic or other NoSQL databases. XML development using XPath, XSLT, or XQuery and CSS/HTML/JavaScript are a must. Additional Skills: Experience in Java, JSP and scripting skill like PERL is preferred. Experience with web services, WCF, AJAX, JQuery, MVC, XRM is an added plus. Experience with Agile development including daily scrum and weekly iteration reviews and planning Educated or experience/background in Analysis and Design, ability to write technical documentation, comprehensive testing. Good communication skills Additional Information Best Regards, Vipul Gupta California Creative Solutions, Inc. 13475 Danielson Street Suite 220 | Poway CA 92064 phone: ************ | fax: ************ *********************

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: Calico seeks a Drug Discovery Principal Program Manager as a key driver in advancing our preclinical drug discovery pipeline from hit generation through to the nomination of a clinical candidate. This role requires exceptional organizational skills, deep scientific understanding of the drug discovery process, and an ability to effectively manage complex, multi-disciplinary projects executed primarily through external CROs. The successful candidate will be able to effectively communicate among the relevant internal and external stakeholders to achieve robust, efficient pipeline operations that support the goals of Calico Drug Discovery. The Program Manager acts as the central hub for communication, planning, and execution, ensuring projects are delivered on-time, within scope, and on-budget, while maintaining the highest scientific and productivity standards for successful preclinical candidate nominations. Responsibilities: * Rigorously monitor CRO performance against the agreed-upon SOW, budget, and timeline, proactively identifying and mitigating potential delays or scope creep * Ensure clear and consistent communication among all internal team members, external CROs, and collaborators * Facilitate and document team meetings to enable cross-functional communication, decision-making, and alignment with internal and external stakeholders * Work closely with project Drug Discovery Team Leader, internal scientific functional leads to define clear milestones, deliverables, and decision points (Go/No-Go criteria) * Meet regularly with stakeholders to assess the states of ongoing projects, identify current or projected problems, and proactively suggest solutions * Lead and/or contribute to the development of processes and tools to enable planning, prioritization, tracking, and execution of pipeline projects * Ensure the seamless and compliant transfer of data, materials, and biological samples between internal facilities and external partners * Manage contracts and financial tracking related to external spend, processing invoices, and forecasting future expenditures with finance and procurement teams * Ensure that business critical contracts are executed in a timely manner * Develop and distribute regular project status reports detailing progress, key findings, risks, and mitigation strategies to senior management and internal stakeholders * Organize and manage project documentation, ensuring all project records and data summaries are centralized, current, and audit-ready * Develop and manage project plans and integrated timelines for pipeline projects as needed Position Requirements: * M.S. or Ph.D. in Chemistry or Biology with a minimum of 7 years of progressive industrial drug discovery project management experience is required * Demonstrated experience in managing multiple external CROs (domestic and international) across different scientific disciplines is essential * Deep scientific literacy in drug discovery processes (e.g., target identification, hit-to-lead, lead optimization, preclinical safety assessment) * PMP (Project Management Professional) certification or an equivalent project management qualification is highly desirable * Expert proficiency with project management software tools, methodologies, and best practices * Experience facilitating and documenting team meetings to enable cross-functional communication, decision-making, and alignment with internal and external stakeholders while managing project scope, deliverables, risks, and resources * Outstanding organization and planning skills to effectively manage competing priorities, resources, and activities within and across a diverse portfolio of projects and programs * Exceptional negotiation, communication, and interpersonal skills required to manage complex relationships with external vendors and internal stakeholders * Proven ability to manage budgets and accurately forecast external expenditures * Strong risk assessment and problem-solving skills, with an ability to function effectively in a fast-paced, high-pressure environment * Ability to effectively communicate complex information, issues, and potential solutions across the organization, including leadership and external collaborators * Ability to foster partnerships and effective collaboration within and across teams * Ability to design and implement medium-to-large-scale process improvements * Must be willing to work onsite at least four days a week The estimated base salary range for this role is $188,000 - $200,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position description: Calico is seeking an intern to join the Gillich lab. To succeed, you will need to be an enthusiastic team player, detail-oriented, extremely organized and comfortable working on complex problems. In this position you will use CRISPR screening and cutting-edge functional genomics approaches to discover lung aging targets. The successful candidate will work closely with members of the Gillich and Cellular Phenotyping labs to establish a platform for co-culturing alveolar organoids derived from primary alveolar type 2 (AT2) cells with alveolar fibroblasts. Using this system, you will screen for reversal of lung aging phenotypes in the co-cultures using phenotypic and transcriptomic readouts. This project will contribute to our goal of understanding mechanisms of aging and identifying interventions that prevent or reverse aging and disease pathologies in the lung. Responsibilities: * Establish alveolar organoid-fibroblast co-cultures * Transduce alveolar cells with lentiviral library * Establish and employ phenotypic readouts (e.g., immunostaining, reporters) * Analyze and interpret imaging and functional genomics data * Contribute to screening strategy and gRNA library design Position requirements: * Currently pursuing a PhD degree, in cellular and molecular biology or related fields * Experience working with organoids and/or co-culture systems * Experience with gene delivery (e.g., viral transduction) * Experience with fluorescence microscopy and immunostaining * Experience with the CRISPR/Cas system * Detail-oriented and organized * Strong teamwork and communication skills * Self-motivated with a "can-do" attitude * Flexible, able to respond quickly to shifting priorities and able to multitask Nice to have: * Experience with phenotypic and/or CRISPR screening * Knowledge of NGS library preparation, including 10x Genomics single cell gene expression library preparation * Experience with Python and/or R, including single-cell and bulk RNA-seq data analysis About our Program: Calico's internship program is a paid 12-week program over the summer for students interested in understanding the fundamental science of aging and finding treatments for the associated and intractable diseases. Working in a collaborative environment and fully embedded in one of our labs/teams, Calico interns tackle a unique project under the mentorship of at least one of our scientists or engineers. Program Features: * 3-month summer timeline * In-person experience at our offices in South San Francisco * Matching with at least one Calico mentor * Group supplemental activities weekly featuring guest speakers, Senior Leadership spotlights, and discussion groups on aging science, our drug development approach, and more * End-of-summer company-wide project showcase and poster session * Competitive compensation ($45 - $70/hour) and monthly living expenses stipend Program Eligibility: * Able to work in-person at our offices in South San Francisco * Free for a consecutive period of 11-12 weeks in June, July, and August * Not graduating before December 2026 * Exception for students enrolling into a graduate degree program in Fall 2026 * Must be enrolled in a US university * Must apply by application deadline: February 1, 2026.

Who We Are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position description: Calico is seeking an intern to join the Translational Data Sciences team. The Translational Data Sciences team bridges the gap between basic science and clinical application to further Calico's mission of extending healthy lifespan. It accelerates Calico's translational research and empowers data-driven decision-making by transforming complex data into actionable insights grounded in biology. The successful candidate will be an enthusiastic team player, detail-oriented, extremely organized and comfortable working on complex problems across a wide range of biological contexts. In this position you will extend Calico's internal AI infrastructure to interface with internal and external sources of single cell sequencing data to enable and accelerate bioinformatics analyses of large-scale datasets for nontechnical users. The successful candidate will work closely with members of the Translational Data Sciences and collaborators in Discovery Technologies and Software Engineering on a broad range of discovery-stage and translational research questions. Responsibilities: * Build and/or refine AI agents to enable Calico scientists to query and analyze internal and external data sources of interest * Coordinate with Software Engineering and relevant stakeholders to deploy the agents on Calico infrastructure for internal usage by Calico scientists * Demonstrate accelerated AI capacity to compile reference single cell datasets to answer relevant scientific questions such as the determination of an expression profile of aging of brain microglia and elucidation of disease-specific genetic signatures of fibrosis * Maintain clear and concise documentation of code, project materials, and analysis results * Concisely communicate intermediate and final results to relevant stakeholders in Calico Computing and Calico R&D Position requirements: * Currently pursuing a BS degree in a computationally intensive field (Mathematics, Computer Science, Bioinformatics, Statistics) or related field * Experience working with Python, Git, Docker, Terraform, and cloud computing platforms such as Google Cloud * Knowledge of best practices for software development, project management, and code versioning * Detail-oriented and organized * Strong teamwork and sharp verbal and written communication skills * Self-motivated, driven, and intellectually curious with a "can-do" attitude * Flexible, able to respond quickly to shifting priorities, and able to multitask Nice to have: * Experience with prompt engineering and designing AI agents is a plus About our Program: Calico's internship program is a paid 12-week program over the summer for students interested in understanding the fundamental science of aging and finding treatments for the associated and intractable diseases. Working in a collaborative environment and fully embedded in one of our labs/teams, Calico interns tackle a unique project under the mentorship of at least one of our scientists or engineers. Program Features: * 3-month summer timeline * In-person experience at our offices in South San Francisco * Matching with at least one Calico mentor * Group supplemental activities weekly featuring guest speakers, Senior Leadership spotlights, and discussion groups on aging science, our drug development approach, and more * End-of-summer company-wide project showcase and poster session * Competitive compensation ($45 - $70/hour) and monthly living expenses stipend Program Eligibility: * Able to work in-person at our offices in South San Francisco * Free for a consecutive period of 11-12 weeks in June, July, and August * Not graduating before December 2026 * Exception for students enrolling into a graduate degree program in Fall 2026 * Must be enrolled in a US university * Must apply by application deadline: February 1, 2026.

Who We are: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico's highly innovative technology labs, its commitment to curiosity-driven discovery science, academic and industry partners, and vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs. Position Description: The Cellular Models and Assay Technologies (CMAT) group at Calico is seeking a talented and creative bench Scientist to lead the design, optimization, and implementation of complex biochemical assays to support our drug discovery efforts. As an expert individual contributor, the successful candidate will perform advanced hands-on laboratory work while also managing external Contract Research Organizations (CROs) to scale our capabilities. The position requires the candidate to have extensive experience in enzymology, in vitro pharmacology, and the biophysical characterization of protein-ligand interactions. In this role, you will act as a thought leader, driving innovative assay technologies to advance therapeutic pipelines and developing novel approaches for the mechanistic elucidation of hit compounds. You will serve as a key technical lead on project teams, integrating early research data to progress programs from target validation through to lead optimization. As such, the ideal candidate will be intellectually and technically nimble, quantitative, collaborative, well-organized, and capable of quickly grasping the fundamentals of new biological systems. Responsibilities: * Lead protein-based assay development, designing and executing complex assays (enzymatic, PPI, protein-nucleic acid) utilizing diverse readouts (Luminescence, TR-FRET, AlphaLISA, FP) and advanced technologies (mass spectrometry, microfluidics) to interrogate novel biological targets * Go beyond routine screening to serve as a thought leader on assay strategy and mechanistic characterization and apply rigorous enzymological and biophysical principles to elucidate mechanism of action, kinetics, and thermodynamics of ligand-target interactions * Serve as a key technical lead on cross-functional teams, partnering with medicinal and computational chemists to drive Structure-Activity Relationship (SAR) cycles * Interpret complex biological data to guide compound design and progress programs from target validation through to lead optimization * Oversee the transition of bench-scale assays to automated high-throughput formats, ensuring statistical rigor (Z-factor), miniaturization, and seamless integration with laboratory automation for large-scale campaigns * Identify, qualify, and manage CRO partners for assay transfer and routine screening; ensure external data quality matches internal standards to support the pipeline Position Requirements: * PhD in Biochemistry, Biophysics, Pharmacology, or a related field, plus 3+ years of industry experience in biochemical assay development within a pharmaceutical or biotechnology setting * Extensive knowledge of steady-state kinetics, enzyme inhibition modes, and the quantitative analysis of protein-ligand interactions with demonstrated ability to apply these principles to elucidate mechanism of action, kinetics, and thermodynamics * Proven track record of designing and validating assays using diverse readouts (TR-FRET, AlphaLISA, FP, Luminescence, Mass Spec) and implementing them on laboratory automation platforms (Echo, Bravo, Hamilton) Advanced quantitative skills with the ability to analyze kinetic data using specialized software (GraphPad Prism, Genedata, CDD, Python, R) and communicate these findings clearly to interdisciplinary teams * Demonstrated experience identifying, onboarding, and overseeing scientific work at external contract research organizations to ensure high-quality data generation * Excellent oral and written communication skills; detail-oriented, organized, flexible, and capable of multitasking in a fast-paced environment * Must be willing to work onsite five days per week Nice to Have: * Experience with orthogonal assay formats, including cell-based assays, complex media (lysates, lipid vesicles), or biophysical assays (SPR, DSF/TSA) Hands-on experience with protein design, expression, and purification from various systems * Familiarity with microfluidics-based assays or High-Throughput Mass Spectrometry (e.g., RapidFire, SAMDI) * Experience with Fragment-Based Drug Discovery (FBDD) or Targeted Protein Degradation (TPD) assay formats (ternary complex formation) The estimated base salary range for this role is $156,000 - $163,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.