Chan Zuckerberg Initiative jobs in Redwood City, CA

The Chan Zuckerberg Initiative was founded in 2015 by Priscilla Chan and Mark Zuckerberg to help solve some of society's toughest challenges - from curing or preventing disease to improving education and addressing the needs of our local communities. We provide the operational support across our areas of work. The Team Across our work in Science, Education, and within our communities, we pair technology with grantmaking, impact investing, and collaboration to help accelerate the pace of progress toward our mission. Our Operations organization provides the support needed to push this work forward. Operations consists of our Brand & Communications, Central Tech, Finance, People, Real Estate/Workplace/Events/Facilities/Security (REWFS), Strategy & Operations, and Ventures teams. These teams provide the essential operations, services, and strategies needed to support CZI's progress toward achieving its mission to build a better future for everyone. The Opportunity The Director of Executive Communications role at CZI is an opportunity for an accomplished senior communications professional to lead executive communications and issues management at a fast paced and innovative philanthropic organization. CZI's mission is to build a more inclusive, just and healthy future for everyone and, as part of the Brand and Communications team, you will help build trust, credibility and engagement to inspire the world to champion and contribute to that mission. This role sits on the Brand and Communications team and reports to CZI's Head of Brand and Communications. In this role, you will partner closely with other senior leaders on the Brand and Communications team as well as throughout the organization, coordinating and planning integrated executive communications and storytelling opportunities across initiatives and programs. What You'll Do Increase understanding of CZI's impact among key audiences through proactive, integrated communication planning, thought leadership content development and active, ongoing media relations. Advance and execute the positioning strategy for CEO(s) and senior leaders, including developing message platforms, identifying and evaluating speaking and media engagements, writing scripts, speeches, talking points, and background materials. Anticipate and mitigate crisis communications issues by monitoring the internal and external landscape, developing communication plans/talking points on relevant issues, and coordinating with key stakeholders and spokespeople. Partner closely with other senior leaders on the Brand and Communications team as well as throughout the organization, coordinating and planning integrated executive communications and storytelling opportunities across initiatives and programs that are optimized for consistency and impact. Serve as CZI spokesperson and prepare other spokespeople as needed. Provide strategic guidance and consultation with cross-functional teams, executives, leaders, and partners. Manage agency partners and consultants in support of the portfolio What You'll Bring 10+ years experience as a senior-level communications practitioner with experience serving as spokesperson and demonstrated ability to establish and maintain media relationships People management experience, including management of outside agencies or contractors. Experience working as an advisor and counselor to senior leaders and executives Crisis and issues management experience Outstanding writing and editing skills; ability to write for a broad spectrum of communications channels. Passion about the work we are doing at CZI Willingness and ability to work collaboratively, adapt to a dynamic work environment, and navigate complexity and multiple priorities to deliver results. Compensation The Redwood City, CA base pay range for a new hire in this role is $193,000.00 - $265,100.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Better Together As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. Provides a generous employer match on employee 401(k) contributions to support planning for the future. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. #LI-Hybrid

The Chan Zuckerberg Initiative was founded in 2015 by Priscilla Chan and Mark Zuckerberg to help solve some of society's toughest challenges - from curing or preventing disease to improving education and addressing the needs of our local communities. We provide the operational support across our areas of work. The Team Across our work in Science, Education, and within our communities, we pair technology with grantmaking, impact investing, and collaboration to help accelerate the pace of progress toward our mission. Our Operations organization provides the support needed to push this work forward. Operations consists of our Brand & Communications, Central Tech, Finance, People, Real Estate/Workplace/Events/Facilities/Security (REWFS), Strategy & Operations, and Ventures teams. These teams provide the essential operations, services, and strategies needed to support CZI's progress toward achieving its mission to build a better future for everyone. The Opportunity The Senior Compensation Analyst plays a critical role in both the strategy and execution of the organization's compensation programs. As a subject matter expert in salary structures, incentive programs, and specialized plans, you'll ensure pay practices are competitive, equitable, and compliant-while also driving hands-on execution during high-demand periods. This role is ideal for someone who thrives in fast-paced environments, can operate independently with minimal oversight, and brings a strong foundation in People Operations. You'll partner closely with the Senior Compensation Manager, as well as the People team, Finance, and Business Systems, to deliver high-impact compensation solutions aligned with organizational goals. This position will initially report to the VP, Total Rewards and People Operations. What You'll Do Compensation Programs & Processes Partner closely with the Senior Compensation Manager to design, maintain, and update job architecture, salary ranges, and career grids. Administer and support annual compensation cycles, including merit, bonus, promotion, and long-term incentive programs. Support off-cycle activities, including one-time payments, title/reporting changes, and specialized compensation plans. Collaborate with People Business Partners, Recruiting, and Finance to provide recommendations for new hires, internal mobility, and retention strategies. HRIS & Data Management Manage Workday Core and Advanced Compensation modules, including job profile updates, plan configurations, bulk data loads (EIBs), and testing/auditing. Maintain and audit key compensation tools and data sources; automate processes where possible. Perform regular audits, reconciliations, and reporting to ensure data integrity and alignment with compensation structures. Market Analysis & Compliance Conduct job evaluations, FLSA classifications, and market pricing analyses to ensure internal equity and external competitiveness. Participate in compensation surveys (e.g., Radford, Mercer), including role matching, data submission, and analysis to ensure accurate benchmarking and alignment with market practices. Monitor market trends and regulatory updates to keep pay practices current and compliant. Stakeholder Engagement & Documentation Partner with the Senior Compensation Manager to build compensation cycle timelines, requirements documentation, and communication materials. Collaborate across People, Finance, and Business Systems to execute compensation cycles smoothly and thoughtfully. Create and maintain compensation documentation, tools, and training resources for managers and employees. What You'll Bring 4-7 years of hands-on compensation experience in dynamic, high-growth, or complex environments. Strong knowledge of compensation principles, job architecture, career frameworks, and incentive design. Advanced proficiency in: Strong analytical and quantitative skills; ability to translate complex data into actionable insights. Proven ability to work independently, execute with precision, and deliver results with minimal guidance. Compensation The Redwood City, CA base pay range for a new hire in this role is $106,000 - $146,300. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Better Together As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. Provides a generous employer match on employee 401(k) contributions to support planning for the future. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. #LI-Hybrid

The Team CZI supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease. Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems - paving the way for new discoveries that will change medicine in the decades that follow: Building an AI-based virtual cell model to predict and understand cellular behavior Developing state-of-the-art imaging systems to observe living cells in action Instrumenting tissues to better understand inflammation, a key driver of many diseases Engineering and harnessing the immune system for early detection, prevention, and treatment of disease CZI's work in science includes grantmaking programs, open-source software development, and close collaboration with the Chan Zuckerberg Biohub Network. The CZ Biohub Network includes the San Francisco, Chicago, and New York Biohubs as well as the Chan Zuckerberg Imaging Institute. CZI also collaborates with institutional partners like the Kempner Institute for the Study of Natural & Artificial Intelligence at Harvard University. Join us in accelerating science. As a Senior Data Scientist, you'll lead the creation of groundbreaking datasets that power our AI/ML efforts within and across our scientific grand challenges. Working at the intersection of data science, biology, and AI, your work will focus on creating large, AI-ready datasets, spanning single-cell sequencing, immune receptor profiling, and mass spectrometry peptidomics data. You will define data needs, format standards, analysis approaches and quality metrics and build pipelines to ingest, transform, and validate data products that form the foundation of our experiments. Our Data Ecosystem: These efforts will form a part of, and interoperate with CZI's larger data ecosystem. We are generating unprecedented scientific datasets that drive biological innovation: Billions of standardized cells of single-cell transcriptomic data, with a focus on measuring genetic and environmental perturbations 10s of thousands of donor-matched DNA & RNA samples 10s PBs-scale static and dynamic imaging datasets 100s TBs-scale mass spectrometry datasets Diverse, large multi-modal biological datasets that enable biological bridges across measurement types and facilitate multi-modal model training to define how cells act. When analysis of a dataset is complete, you will help publish it through public resources like CELLxGENE Discover, the CryoET Portal, and the Virtual Cell Platform, used by tens of thousands of scientists monthly to advance understanding of genetic variants, disease risk, drug toxicities, and therapeutic discovery. Your Impact You'll collaborate with cross-functional teams to lead dataset definition, ingestion, transformation, and delivery for AI modeling and experimental analysis. Success means delivering high-quality, usable datasets that directly address modeling challenges and accelerate scientific progress. Join us in building the data foundation that will transform our understanding of human biology and move us along the path to curing, preventing, and managing all disease. What You'll Do Contribute the tools required for a robust data ecosystem: build single cell data ingestion pipelines, select data formats, standards, and database schemas, and write validation tools, QC approaches, and analysis pipelines. Collaborate with Platform Scientists, ML engineers, AI Researchers, and Data Engineers to iteratively evaluate, refine and grow datasets to improve our biological understanding of inflammation. Work closely with Platform Scientists to identify technical variables and devise approaches to harmonize data across generation sites to enable joint analysis. Discover and define new data generation opportunities, and manage the delivery of those data products to our scientific teams. What You'll Bring 10+ years of experience with large scale high throughput biological data (single cell sequencing, immune receptor profiling, mass spectrometry). Demonstrated ability to deliver multiple large biological data products. Experience with big data: extraction, transport, loading, databases, standardization, validation, QC, and analysis. Experience with processing and orchestration pipelines, such as Argo Workflows, Databricks Strong fundamentals in statistical reasoning and machine learning. Experience with biological data analysis and QC best practices Excellent written and verbal communication skills. Enthusiasm to ramp up on technologies and learn new domains. Experience working in a multidisciplinary environment (scientific platforms, engineering, product, AI Research). Compensation The Redwood City, CA base pay range for this role is $190,000 - $261,800. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Work Mode As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Team At Learning Commons, we pair technology with grantmaking to scale proven teaching and learning practices to benefit every learner. We aim to translate what learning science tells us about how students learn best into classroom practice. With the advent of generative AI, that translation work can be accelerated and scaled to have a greater impact. Our mission is to bring learning science into the tools used every day by teachers and students, ensuring that technology reflects the realities of classrooms and strengthens teaching and learning. In today's fragmented edtech landscape, school districts are often left piecing together products that don't always align with curricula or instructional needs. While AI holds enormous potential to support educators, it can only deliver on that promise when grounded in research, high-quality educational data, and expert evaluation. That's why we're building open, public-purpose infrastructure - datasets, rubrics, and resources - that help raise the standard for educational tools and create more consistent, impactful learning experiences for all students and teachers. At our core, we are builders, and our unique builder philanthropy approach is what sets us apart from other education funders. Take a closer look at the highlights and significant milestones of CZI's first eight years of education work. The Opportunity We are seeking an Applied Learning Scientist to support our team in translating learning science research into educational products and partnerships. This position offers the opportunity to contribute to initiatives that inform our product development strategy and support pedagogical innovation. You'll work on diverse projects and assignments while building your expertise in applied learning science within the educational technology space. What You'll Do Execute diverse learning science work involving independent judgment and analysis while developing professional expertise in evidence-based learning practices Guide and participate in planning workstreams that impact work components and processes of broader learning science projects Advise on pedagogical alignment of programs or partnerships within learning science disciplines, contributing to research, identification and recommendation of partners, technologies and best practices Analyze various learning science inputs including feasibility, market and other factors to support product roadmaps and strategy decisions Contribute to development of project roadmaps while ensuring best pedagogical practices are integrated Interact with learning science partners to support initiatives and manage nuanced interactions with guidance from senior team members Evaluate diverse applications of learning science principles and assess impact of programs or projects on desired learning outcomes Develop pedagogical insights and provide feedback to development teams on learning science recommendations What You'll Bring Demonstrated experience in most areas of the Applied Learning Science function with in-depth specialization in some areas Comprehensive understanding of evidence-based learning practices and principles Proven experience advising on project, program and product development with multiple stakeholders Strong communication and presentation skills with the ability to effectively reach audiences with a range of experiences and understanding Ability to work as a team consultant with skills in inclusively soliciting input to build momentum for decisions and establishing relationships across teams Independent approach to recommending solutions for new assignments where projects regularly require new methods and approaches Experience building relationships with diverse researchers, external agencies, nonprofits, programs and service providers to build support for evidence-based learning initiatives Compensation The Redwood City, CA base pay range for this role is $106,000 - $146,300. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Work Mode As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be on-site for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. Provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. #LI-Hybrid

The Chan Zuckerberg Initiative was founded in 2015 by Priscilla Chan and Mark Zuckerberg to help solve some of society's toughest challenges - from curing or preventing disease to improving education and addressing the needs of our local communities. We provide the operational support across our areas of work. The Team At CZI, we pair technology with grantmaking, impact investing, and collaboration to accelerate progress in Science, Education, and our communities. Our Legal and Investment teams provide the foundation that supports this mission. Team LeGiT ensures CZI operates lawfully and responsibly, partnering across the organization to provide clear, practical legal guidance. The Investment team manages CZI's funding entities through a manager-of-managers approach, partnering with top-tier investment firms globally across asset classes to sustain long-term giving and enable lasting impact aligned with our mission. This Legal Counsel - Investments role will report to the Legal team but be embedded with and focused on the Investment team's work-advising on legal and regulatory matters, supporting fund negotiations and diligence, and helping ensure compliant and effective investment execution. The Opportunity CZI is seeking a thoughtful and mission-aligned investment legal attorney to join our Investments team, with a direct reporting line to CZI's General Counsel and a dotted line to the Investment team. This is CZI's first dedicated investment legal counsel role-an exciting opportunity to help shape and build the legal foundation for our growing investment program. You will be fully integrated into the Investment team's legal work, partnering closely with investment professionals and outside counsel on the legal aspects of public and private fund investments, co-investments, and related opportunities. You will bring prior experience advising on fund matters and apply that expertise as you collaborate with investment professionals in structuring, reviewing, and negotiating deals that span tax-exempt and taxable entities. In this role, you will provide strategic legal support across CZI's investment activities, ensuring that fund agreements, side letters, and related documentation align with legal, regulatory, and entity-specific requirements. You will advise on fund structuring, co-investment terms, and regulatory risks unique to each investment vehicle, incorporating key considerations applicable to tax-exempt and mission-driven entities. You will be a key partner, translating legal complexity into practical, high-quality guidance. You will be a builder, developing investment legal frameworks, templates, and internal guidance to streamline fund reviews and ensure consistency across CZI's investment legal processes. You will also be a collaborator, forging strong relationships across investment, legal, and external stakeholders to support the organization's investment activity with clarity and rigor. We're looking for an experienced fund attorney with a strong foundation in private and or public investment fund work, excellent legal judgment, and a collaborative mindset. If you're energized by the chance to build something new, partner across functions, and contribute to a dynamic, mission-driven organization, we'd love to hear from you. What You'll Do In collaboration with investment professionals, lead the legal process for fund and co-investment opportunities, including analysis of LPAs, PPMs, subscription materials, and related documentation, with adaptations based on the specific structure of the investing CZI entity and its goals. Draft legal issue summaries and advise the investment team on implications based on entity type and applicable regulations. In rendering this advice, you will collaborate with our in-house attorneys who specialize in tax exempt law. Partner with investment professionals and external counsel to negotiate terms, including terms that pertain to CZI's legal exposure and tax-exempt profile. Draft and negotiate tailored side letters that address the unique legal requirements of taxable and tax-exempt organizations. Coordinate with tax advisors and legal counsel to incorporate tax considerations and ensure regulatory compliance across entity types, including compliance with the disclosure requirements under securities laws. Serve as a legal resource during the negotiation of NDAs, IMAs, subscription agreements, and AML/KYC materials to help ensure compliance with applicable legal and regulatory standards. Manage post-investment obligations including MFN rights, amendments, and consents across investment vehicles. Monitor legal, tax, and policy developments relevant to philanthropic, tax-exempt, and taxable entities. Create and maintain internal documentation to reflect recurring issues and preferred terms across CZI's varied investment structures. What You'll Bring 6+ years of legal experience in fund and asset management, with a focus on hedge funds and private equity. Strong preference for law firm experience. Additional experience working in-house is a plus. Expertise should include investor-side review and negotiation of fund agreements-including limited partnership agreements, separately managed accounts, and co-investment vehicles-as well as key supporting documents such as NDAs and other administrative agreements. Extensive experience and expertise in investor-side review and negotiation of fund agreements, including across varied legal structures. Familiarity with compliance and regulatory issues for taxable and tax-exempt and mission-driven investors (e.g., EBH, UBTI, self-dealing). Familiarity with applicable securities law filings. Exceptional academic background and demonstrated excellence in legal writing, analytical thinking, and communication. Strong desire to join a mission-driven, philanthropic culture. Proven ability to navigate complex internal and external stakeholder environments with professionalism and efficiency. Strong relationship-building skills and a commitment to high-quality, mission-aligned client service. Uncompromising integrity, discretion, and collaborative approach in a fast-paced setting. JD required and active membership in the California state bar (or willingness to relocate to the SF Bay Area and sit for the California state bar). Compensation The Redwood City, CA base pay range for a new hire in this role is $225,000 -$265,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. In addition to base salary, this role is eligible for a discretionary target bonus, based on individual and company performance. Bonus eligibility and targets are determined in accordance with CZI's total rewards philosophy and may vary by role. Work Mode As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Team CZI supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease. Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems - paving the way for new discoveries that will change medicine in the decades that follow: Building an AI-based virtual cell model to predict and understand cellular behavior Developing state-of-the-art imaging systems to observe living cells in action Instrumenting tissues to better understand inflammation, a key driver of many diseases Engineering and harnessing the immune system for early detection, prevention, and treatment of disease CZI's work in science includes grantmaking programs, open-source software development, and close collaboration with the Chan Zuckerberg Biohub Network. The CZ Biohub Network includes the San Francisco, Chicago, and New York Biohubs as well as the Chan Zuckerberg Imaging Institute. CZI also collaborates with institutional partners like the Kempner Institute for the Study of Natural & Artificial Intelligence at Harvard University. Join us in accelerating science. The AI/ML team is funding and building one of the largest computing systems dedicated to nonprofit life sciences research in the world. This new effort will provide the scientific community with access to predictive models of healthy and diseased cells, which will lead to groundbreaking new discoveries that could help researchers cure, prevent, or manage all diseases by the end of this century. The Opportunity As a Research Engineer on the AI Engineering team you will apply and optimize state-of-the-art models in artificial intelligence and machine learning to solve important problems in the biomedical sciences aligned with CZI's mission. You will work as part of a team responsible for developing and deploying AI models that use data developed by CZI and research partners all for the purpose of contributing to greater understanding of human cell function. You will have the opportunity to work closely with teams of scientists, computational biologists, engineers within CZI and to collaborate with CZI grantees, with CZ institutes, and other external labs and organizations. Your work will inspire and enhance the production and analysis of datasets by CZ teams and collaborators. Scientific focus areas could include single cell biology, imaging, genomics, and proteomics. What You'll Do Working with the AI Research Scientists, iterate on, optimize, deploy, and maintain innovative machine learning models, systems, and software tools that enable the analysis and interpretation of AI models for Biology Work with cross-functional team members to quickly iterate on system performance to meet/stay ahead of users' needs - e.g. we get feedback that the model doesn't scale to X million so working with our user researcher/scientist/product team to iterate on the solution. Partner with research scientists to build robust data loader pipelines for scalable distributed training and evaluation. Serve as an interface to product and engineering teams to understand how models may need to evolve to support multiple use cases. Develop model evaluation and interpretability frameworks that help biologists understand which data features drive model predictions Build reusable engineering utilities that can unlock experimentation velocity across research initiatives in the organization Optimize model architectures to enhance performance, fine-tune accuracy, and efficiently manage infrastructure resources What You'll Bring Experience in working with a highly interactive and cross-functional collaborative environment with a diverse team of colleagues and partners solving complex problems through applied deep learning. A track record and expertise in developing deep learning models on large-scale GPU clusters, using techniques of distributing training such as DDP, FSDP, Model parallelism, low-precision training, profiling and optimizing AI/ML code, fine tuning models. Expertise in leading end-to-end experimentation pipelines for training and evaluating deep learning models, with particular focus on experiment tracking and reproducibility. A good working knowledge of Python-based ML libraries and frameworks such as PyTorch, JAX, TensorFlow, NumPy, Pandas, and Scikit-learn. Experience in using modern frameworks for distributed computing and infrastructure management, particularly as related to ML models such as PyTorch Lightning, Deepspeed, TransformerEngine, RayScale etc. Ability to effectively balance exploratory research with robust engineering practices. A good working knowledge of general software engineering practices in a production environment. The ability to work independently and as part of a team, and have excellent communication and interpersonal skills. Have a Masters in computer science with a focus on machine learning & data analytics, or equivalent industry experience and at least 6-8 years of experience developing and applying machine learning methods. Compensation The Redwood City, CA base pay range for a new hire in this role is $241,000 - $362,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Work Mode As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Team At Learning Commons, we pair technology with grantmaking to scale proven teaching and learning practices to benefit every learner. We aim to translate what learning science tells us about how students learn best into classroom practice. With the advent of generative AI, that translation work can be accelerated and scaled to have a greater impact. Our mission is to bring learning science into the tools used every day by teachers and students, ensuring that technology reflects the realities of classrooms and strengthens teaching and learning. In today's fragmented edtech landscape, school districts are often left piecing together products that don't always align with curricula or instructional needs. While AI holds enormous potential to support educators, it can only deliver on that promise when grounded in research, high-quality educational data, and expert evaluation. That's why we're building open, public-purpose infrastructure - datasets, rubrics, and resources - that help raise the standard for educational tools and create more consistent, impactful learning experiences for all students and teachers. At our core, we are builders, and our unique builder philanthropy approach is what sets us apart from other education funders. Take a closer look at the highlights and significant milestones of CZI's first eight years of education work. The Opportunity Shape the future of learning! We're seeking an experienced Technical Program Manager Director, Education to lead our team and drive impactful initiatives at the intersection of technology and education. You will report directly to our Head of Education and VP, Product and partner with the education leadership team on operational strategy to help us work well cross-functionally and deliver excellent products and partnerships. This is a great opportunity to build and lead Education's Technical Program Management team and additional operational capabilities. As a Technical Program Manager Director, Education, you will proactively focus on setting the direction and developing and executing the operational strategy that optimizes our resources across education. In this role, you'll be a key leader within Learning Commons, responsible for developing and executing the operational strategy that maximizes our impact on students and educators. You'll collaborate closely with Learning Commons leadership, product, engineering, and partnerships to ensure alignment, drive efficient decision-making, and accelerate the delivery of transformative solutions. What You'll Do Drive Impact: Partner with other leaders of the Learning Commons team to set an operational strategy for our resources - time, people, funds - that enables us to do unique cross-sector work across philanthropic, education, and technology sector values and strengths Optimize Process: Lead and support overall organizational execution and team culture by designing and directing program management practices and processes that enable our strategic goals, tactical work, and the culture and values we need and desire. We see process as a manifestation of culture and believe it can facilitate the inclusivity we desire and the execution speed and quality we need. Foster Collaboration: Work with product, engineering, and partnership leaders to lead and manage the significant processes that support leadership team alignment, execution, and accountability - these include leadership space and support for stakeholders, including our founders/CEOs and our advisory board Champion Innovation: Develop and own processes that enable efficient decision-making, communication, delegation, and accountability; monitor organizational health and plan around corners in the spirit of continuous improvement Cultivate Team Excellence Manage a small but mighty team of technical and non-technical program managers who operate critical projects and processes, including major planning processes (strategic, financial, technical); internal communications mechanisms (helping the organization feel inspired, informed, connected across a hybrid team); product, engineering, design, and data team delivery processes (roadmapping, Jira tracking); central collaborations; executive administrative collaboration and norms; build and oversee developer relations and support team, internal and external stakeholder support, and more. Be Flexible: Demonstrate adaptability and proactive problem solving by anticipating challenges and opportunities and adjusting strategies and your scope as needed to drive change, continuous improvement and innovation. What You'll Bring Proven leadership: Minimum 10 years of experience managing in complex sectors like education, enterprise, or government, along with 5 or more years of leadership experience leading and managing technology teams. Must have experience with leading fast moving and scaling organizations. Technology Management Expertise: Prior experience working closely with software teams as a technical program manager, product manager or engineering manager is a plus Strategic Mindset: Deep organizational and managerial intelligence and experience that helps you innovate on approaches to supporting teams with professional backgrounds spanning sectors towards unified strategy, goals and roadmaps Collaboration and Influence: Exceptional at relationship-building and influencing others to move towards bigger goals. You are low-ego about enabling others but you are not shy about holding the line when needed and getting buy-in on clear priorities to help the team execute well. First Principles and Analytical Decision Making: Comfortable with the ambiguity of exploration and innovation. You bring a strong understanding of first principles and data driven decision making. Process Design: You can see around corners organizationally and operationally to identify where issues stem from and structural gaps in process and/or leadership. You know how to build the right sized process to get the job done and grow the capacity of the organization. Creativity and Humility: People want to work with you because you are excellent at what you do, always trying to innovate, create, and improve, yet you bring a humility that lifts others up Passion for Education: Strong intrinsic drive to help deliver impact at the opportunities at the intersection of technology and education Compensation The Redwood City, CA base pay range for a new hire in this role is $225,000 - $309,100. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. Provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our benefits and interview process at ******************************* #LI-Hybrid

The Team CZI supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease. Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems - paving the way for new discoveries that will change medicine in the decades that follow: Building an AI-based virtual cell model to predict and understand cellular behavior Developing state-of-the-art imaging systems to observe living cells in action Instrumenting tissues to better understand inflammation, a key driver of many diseases Engineering and harnessing the immune system for early detection, prevention, and treatment of disease CZI's work in science includes grantmaking programs, open-source software development, and close collaboration with the Chan Zuckerberg Biohub Network. The CZ Biohub Network includes the San Francisco, Chicago, and New York Biohubs as well as the Chan Zuckerberg Imaging Institute. CZI also collaborates with institutional partners like the Kempner Institute for the Study of Natural & Artificial Intelligence at Harvard University. Join us in accelerating science. The Opportunity We are seeking an experienced Principal Technical Program Manager to report to the Vice President of Imaging Science and support cross-functional teams in the planning, execution, and delivery of ambitious imaging science and technology projects. The ideal candidate will combine strong technical knowledge with exceptional program management skills to guide complex initiatives from conception to scalable implementation. This role will play a key part in developing innovative technologies and ensuring they are positioned for broad impact - including successful translation and adoption across academic research institutions and commercial industry settings. The Technical Program Manager will shape the execution required to scale scientific tools and platforms in a way that supports CZI Imaging Institute's mission to democratize access and maximize global scientific benefit. This on-site position will be based in San Francisco, CA. What You'll Do Coordinate multidisciplinary teams in the planning, execution, and scaling of complex imaging technology projects that bridge scientific discovery and translational application, with direct alignment to biological use cases. Lead cross-functional project planning with a focus on transitioning prototype technologies into scalable, reproducible tools that can be adopted across diverse academic and commercial environments. Develop comprehensive project roadmaps including scope, scale-up strategy, timelines, resource allocation, risk assessments, commercialization pathways, and budgets. Manage cross-platform integration and execution across hardware, software, probes, and data science teams, ensuring readiness for broader deployment. Track impact metrics including publications, platform performance, and adoption metrics across both research and industry ecosystems. Proactively identify scalability bottlenecks and dependencies, and implement mitigation plans to enable sustainable, widespread technology use. Serve as a liaison between scientific researchers, productization teams, and industry collaborators to ensure successful technology transfer and scaling pathways. Communicate project milestones and risks clearly to stakeholders across technical and non-technical domains. What You'll Bring Bachelor's degree in bioengineering, imaging sciences, computational engineering, or a related technical field; Master's or PhD preferred. 12+ years of experience managing complex technical programs with demonstrated success in scaling scientific technologies from early-stage research through to operational deployment across academia and/or industry, preferably in imaging technology or related fields. Strong understanding of biological imaging systems, computational tools, and integrated hardware/software platforms, with awareness of translational science challenges. Demonstrated experience driving the adoption of novel technologies across diverse environments, including managing validation pipelines, documentation, user training, and feedback loops. Proven track record in coordinating partnerships or consortia that span academic institutions, biotech, and/or commercial organizations. Experience implementing programmatic strategies that enable sustainable growth and technology scalability. Excellent systems thinking, with the ability to bridge scientific innovation with practical implementation and stakeholder alignment. Strong communication skills and the ability to influence and align diverse technical and non-technical partners around scale-up strategies. Experience with regulatory, intellectual property, or licensing considerations in the context of technology transfer is a plus. Compensation The Redwood City, CA base pay range for this role is $214,000.00 - $294,800.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Onsite

The Team Across our work in Science, Education, and within our communities, we pair technology with grantmaking and collaboration to help accelerate the pace of progress toward our mission. Our Investment team provides the support needed to push this work forward. The investment team's goal is to manage the investment portfolio to fund CZI's ongoing operations over the long term. The investment program pursues a “manager of managers” approach, scouring the globe to find extraordinary investment organizations that invest across a wide spectrum of styles and asset classes. The Opportunity CZI's investment analyst program offers the unique opportunity to learn about the world of investing. The investment team seeks to build a portfolio that will deliver superior risk-adjusted returns to fund CZI's ongoing operations. We pursue a manager of managers approach, seeking out exceptional partners that invest across geographies into public equities, hedge funds, leveraged buyouts, venture capital, and real assets. Investment analysts will have broad exposure to all asset classes, while focusing on a subset day-to-day. Investment analysts enjoy early responsibility, work directly with senior staff, and are engaged in all aspects of the investment process from day one. This includes traveling to participate in meetings with world-class investment managers, closely monitoring existing investments, and helping manage and report on the portfolio as a whole. We are looking for intellectually curious candidates with an interest in investing, exceptional communication skills, and a desire to work collaboratively as part of a team. We value thoughtfulness, analytical rigor, and the pursuit of excellence. Please note that CZI also has a separate team that makes mission-aligned impact venture investments. That work sits outside of the Investments function. What You'll Do Conduct due diligence on existing and prospective investment managers, including participating in meetings and calls, and play an active role in internal discussions related to investment decisions Build investment models, develop performance analyses, and monitor exposures at both the fund and portfolio level utilizing software/systems (including Excel) Prepare materials for internal team meetings, external manager meetings, and quarterly board meetings Research financial markets, including preparing periodic updates on financial market performance and “deep dives” into specific areas of interest Travel for investment-related research from time to time Build relationships with investment managers and peer institutions Develop a toolkit and grow as an investor through hands-on training and mentorship What You'll Bring An ideal candidate is a college senior (class of 2026) looking for job opportunities after graduation. We welcome all majors to apply! Strong intellectual curiosity An interest in financial markets and desire to learn how to build successful investment portfolios An ability to work collaboratively in a team environment Excellent written and verbal communication skills Strong quantitative and analytical skills Strong time management skills with ability to multi-task and prioritize across projects to meet deadlines Please have your completed application submitted by 9:00 PM PT on Sunday, October 26th. Compensation The Redwood City, CA base pay range for this role is $100,000-$120,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Team CZI supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease. Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems - paving the way for new discoveries that will change medicine in the decades that follow: Building an AI-based virtual cell model to predict and understand cellular behavior Developing state-of-the-art imaging systems to observe living cells in action Instrumenting tissues to better understand inflammation, a key driver of many diseases Engineering and harnessing the immune system for early detection, prevention, and treatment of disease CZI's work in science includes grantmaking programs, open-source software development, and close collaboration with the Chan Zuckerberg Biohub Network. The CZ Biohub Network includes the San Francisco, Chicago, and New York Biohubs as well as the Chan Zuckerberg Imaging Institute. CZI also collaborates with institutional partners like the Kempner Institute for the Study of Natural & Artificial Intelligence at Harvard University. Join us in accelerating science. The Opportunity At CZI, we are generating unprecedented scientific datasets that drive biological modeling innovation: Billions of standardized cells of single-cell transcriptomic data, with a focus on measuring genetic and environmental perturbations 10s of thousands of donor-matched DNA & RNA samples PB-scale static and dynamic imaging datasets TB-scale mass spectrometry datasets Diverse, large multi-modal biological datasets that enable biological bridges across measurement types and facilitate multi-modal model training to define how cells act. Infrastructure to support the ingestion, validation, standardization, use, and publishing of these datasets As a Principal Product Manager, you'll be responsible for packaging and releasing these datasets as products for the broader scientific community, for co-releasing tools and infrastructure that enable scientists to leverage the data effectively to train models, for maintaining and growing CZI's brand as a leader of open science, and for establishing sustainable access policies that control costs of massive-scale data access. Join us in building the data foundation that will transform CZI's model training efforts, and accelerate our and the scientific community's understanding of human biology so that we can cure, prevent, and manage all disease. What You'll Do Define the long-term product vision and 3-year strategic roadmap for CZI's foundational scientific datasets, describing how they enable CZI's scientific challenges, establishing our datasets as definitive, high-value products for the global scientific community. Own the 'Data-as-a-Product' experience, including defining dataset schemas, metadata standards, documentation, and tooling co-releases that maximize scientists' ability to leverage the data for biological modeling. 📦 Establish and execute the market strategy for the data products, identifying key scientific user segments, driving community adoption, and fostering an ecosystem of tools built atop CZI's open data. Define and monitor key product success metrics (e.g., scientific citation count, model training usage, external adoption rate, cost-per-user efficiency) to ensure CZI's investment generates maximum scientific return. Develop and maintain transparent, cost-aware access and governance policies that ensure data security, regulatory compliance, and the long-term sustainability of hosting petabyte-scale scientific resources. Serve as the primary external advocate and evangelist for the data products, collaborating with scientific leaders, grantees, and data platform partners to grow CZI's brand as a leader in open, transformative scientific data. What You'll Bring Deep domain expertise in very-large-scale data, as demonstrated by management of 2 or more very large scale (100s TBs-PBs) data products across multiple phases of their lifecycles. Proven mastery of the product lifecycle, including conducting market research, defining user personas (e.g., academic researcher, industry data scientist), translating complex data into clear, consumable product packages, release, scaling, and sunsetting of products. Expertise in establishing product-market fit and driving adoption within a highly specialized technical community, demonstrating impact on user workflow acceleration. Demonstrated ability to establish and evolve business models or sustainable access policies for massive-scale data, balancing open science principles with operational and cost constraints. Experience leading and influencing cross-functional teams (Engineering, Science, Legal, Finance) to align on a singular product vision for foundational scientific assets. 12+ years of product management experience, with a demonstrated track record of defining, launching, and scaling data products or scientific platforms for an external community. Compensation The Redwood City, CA base pay range for a new hire in this role is $214,000.00 - $268,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Better Together As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Team Founded by Priscilla Chan and Mark Zuckerberg in 2015, the Chan Zuckerberg Initiative (CZI) is a new kind of philanthropy that's leveraging technology to help solve some of the world's toughest challenges - from eradicating disease, to improving education, to reforming the criminal justice system. Our mission is to create a future for everyone. Across our core Initiative focus areas of Science and Education, we're pairing engineering with grantmaking, impact investing, policy work, and movement building, to help build an inclusive, just and healthy future for everyone. Our Values We believe we can help build a future for everyone. We aim to be daring, but humble: We look for bold ideas - regardless of structure and stage - and help them scale by pairing engineers with subject matter experts to build tools that accelerate the pace of social progress. We want to learn fast, but build for the long-term: We want to iterate fast and help bring new solutions to the table, but we also realize that important breakthroughs often take decades, or even centuries. Stay close to the real problems: We engage directly in the communities we serve because no one understands our society's challenges like those who live them every day. Our success is dependent on building teams that include people from different backgrounds and experiences who can challenge each other's assumptions with fresh perspectives. To that end, we look for a diverse pool of applicants including those from historically marginalized groups - women, people with disabilities, people of color, formerly incarcerated people, people who are lesbian, gay, bisexual, transgender, and/or gender nonconforming, first and second generation immigrants, veterans, and people from different socioeconomic backgrounds. The Opportunity Our Central Tech team provides technology and security support for CZI, the Biohub Network, and our grantees. We believe that Engineering and Security are most effective when in sync and learning from each other on a daily basis. Our AI Infrastructure Engineering team enables our AI Research teams to achieve their goals faster and more securely. We leverage technology to automate manual processes, constantly innovate to optimize operations, provide first-class support, and build solutions to enable the scale and execution of our business partners' strategies and initiatives. The AI/ML and Data Engineering Infrastructure organization works on building shared tools and platforms to be used across all of the Chan Zuckerberg Initiative, partnering and supporting the work of a wide range of Research Scientists, Data Scientists, AI Research Scientists, as well as a broad range of Engineers focusing on Education and Science domain problems. Members of the shared infrastructure engineering team have an impact on all of CZI's initiatives by enabling the technology solutions used by other engineering teams at CZI to scale. A person in this role will build these technology solutions and help to cultivate a culture of shared best practices and knowledge around core engineering. What You'll Do Provide technical MLOps leadership: for a team of MLOps Engineers, where you will manage and lead the team in operating our heterogeneous AI training and inference systems as well as collaborating in the design and build of our AI platform components. Drive the application of MLOps and DevOps principles: across our multiple platforms, ensuring peak operational efficiency across our AI operations and process automation necessary for a world class large scale AI model training environment. Instrumentation and Observation technical leadership: for the MLOps team, defining our end to end metrics program including full proactive monitoring and alerting systems Facilitate model training through collaboration with our AI Researchers: alongside the rest of the AI Infrastructure Eng team work together to make sure that our models we are training and releasing to inference make use of best machine learning and deep learning practices, and are through code automation libraries fully resilient to restarts and checkpoint recoveries. Continuous Optimization of our Kubernetes based AI Lifecycle platform: through our IAC based practices and integrating our MLOps AI Lifecycle platform tooling, alongside integrating this with our On-Prem HPC systems into a cohesive heterogeneous platform. Collaboration on Data systems for our AI model training: with our Data Infrastructure Eng team as well as the Science data teams on the end to end data usage that drive our AI model training. Lead our MLOps team supporting our on-call rotation: combining a focus on automation and proactive alerting focused on reducing on-call loads and improving self healing AI system operations. This will be low volume, but we do have 24/7 coverage, and will include members of the rest of the AI team for escalation and on-call coverage. What You'll Bring BS, MS, or PhD degree in Computer Science or a related technical discipline or equivalent experience 7+ years of relevant coding and systems experience 5+ years of systems Architecture and Design experience, with a broad range of MLOps experience across Data Infrastructure and AI/ML platforms Proven technical leadership in SRE and MLOps related experience, as well as either direct or indirect people management experience Proven SRE and MLOps knowledge and related experience Strong experience scaling containerized applications on Kubernetes or Mesos, including expertise with creating custom containers using secure AMIs and continuous deployment systems that integrate with Kubernetes or Mesos. (Kubernetes preferred) Cloud Platform proficiency with Amazon Web Services (AWS), Google Cloud Platform (GCP), or Microsoft Azure, and experience with On-Prem and Colocation Service hosting environments MLOps experience working with medium to large scale GPU clusters in Kubernetes (Kubeflow), HPC environments, or large scale Cloud based ML deployments Working knowledge of Nvidia CUDA and AI/ML custom libraries. Knowledge of Linux systems optimization and administration Solid Coding experience Proven coding ability with a systems language such as Rust,C/ C++, C#, Go, Java, or Scala Expertise with a scripting language such as Python (preferred), PHP, or Ruby Experience in integrating Data with the AI Lifecycle AI/ML Platform Operations experience in an environment integrated with challenging data and systems platform challenges Large scale Streaming data systems integration experience Hadoop, Spark, and/or Kafka deployments, or their corollaries such as Pulsar, Flink, and/or Ray) Workflow scheduling tools such as Apache Airflow, Dagster, or Apache Beam Understanding of Data Engineering, Data Governance, Data Infrastructure, and AI/ML execution platforms. PyTorch, Keras, or Tensorflow experience a strong nice to have HPC with and Slurm experience a strong nice to have Compensation The Redwood City, CA base pay range for this role is $241,000 - $331,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Work Mode As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Team At Learning Commons, we pair technology with grantmaking to scale proven teaching and learning practices to benefit every learner. We aim to translate what learning science tells us about how students learn best into classroom practice. With the advent of generative AI, that translation work can be accelerated and scaled to have a greater impact. Our mission is to bring learning science into the tools used every day by teachers and students, ensuring that technology reflects the realities of classrooms and strengthens teaching and learning. In today's fragmented edtech landscape, school districts are often left piecing together products that don't always align with curricula or instructional needs. While AI holds enormous potential to support educators, it can only deliver on that promise when grounded in research, high-quality educational data, and expert evaluation. That's why we're building open, public-purpose infrastructure - datasets, rubrics, and resources - that help raise the standard for educational tools and create more consistent, impactful learning experiences for all students and teachers. At our core, we are builders, and our unique builder philanthropy approach is what sets us apart from other education funders. Take a closer look at the highlights and significant milestones of CZI's first eight years of education work. The Opportunity Educators are already using AI-based tools in various ways-including generating lesson plans, creating classroom materials such as tests and assignments, and helping differentiate instruction for students. We are inspired and excited about the possibilities and promise of AI to accelerate the availability of research-backed practices at scale. We are actively and thoughtfully exploring how to incorporate AI into products in close partnership with researchers, experts, and educators. As a Senior Machine Learning Engineer on the AI/ML team, you will play a crucial role in translating cutting-edge AI research and exploration into tangible tools and capabilities. You'll work on applying and scaling machine learning models to address specific educational challenges. You'll have the opportunity to own significant features and contribute to the design of robust, scalable ML systems. What You'll Do Design, develop, and deploy machine learning models and systems to address key educational use cases, taking ownership of specific features or small projects. Implement and optimize techniques such as fine-tuning, Retrieval Augmented Generation (RAG), and other deep learning methods for applications in the education domain. Collaborate closely with product managers, data scientists, staff engineers, and expert partners to understand requirements, iterate on solutions, and deliver impactful AI-driven features. Contribute to the development of multi-modal AI systems and ensure their scalability and reliability. Stay current with new developments in AI/ML research and identify opportunities for their practical application within the team's projects. Write robust, well-tested, and maintainable code, and participate actively in code and design reviews. What You'll Bring Enjoy working in a highly interactive and cross-functional collaborative environment with a diverse team of colleagues and external partners. Typically, a minimum of 5 years of relevant industry experience in developing and applying machine learning methods. Solid experience building, training, and deploying AI/ML models, with a good understanding of deep learning methods. Proficiency in programming languages commonly used in ML (e.g., Python) and familiarity with relevant ML frameworks and libraries. Experience in translating ML research or prototypes into functional software and features. Ability to execute on a diverse range of work and own small projects or features within a larger system, often with little day-to-day guidance. Strong problem-solving skills and the ability to work effectively in a highly interactive, cross-functional, and collaborative environment. Compensation The Redwood City, CA base pay range for a new hire in this role is $214,000-$321,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Work Mode As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. Provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Chan Zuckerberg Initiative was founded in 2015 by Priscilla Chan and Mark Zuckerberg to help solve some of society's toughest challenges - from curing or preventing disease to improving education and addressing the needs of our local communities. We provide the operational support across our areas of work. The Team Across our work in Science, Education, and within our communities, we pair technology with grantmaking, impact investing, and collaboration to help accelerate the pace of progress toward our mission. Our Legal and Grants Team (“Team LeGiT”) provides the support needed to push this work forward. Team LeGiT helps accelerate CZI's mission by ensuring that CZI operates lawfully. This team collaborates with teams across CZI to help ensure our organization and grantmaking are in compliance with applicable laws and regulations and will advise internal partners accordingly. The Opportunity As legal counsel on the Contracts subteam, you will collaborate with teams across CZI, including Biohub and Learning Commons. You will help us manage, draft, negotiate, and execute contracts and lead legal projects critical to the success of our strategic mission and operational goals. In addition to working with scientists, engineers, educators and operators to help the organization achieve its ambitious missions, you will also assist in the development and maintenance of our org-wide contracts management systems, policies, and processes. You will manage Contract Management professionals and report to and work closely with the Director, Contracts. What You'll Do Review, analyze, negotiate, draft, and finalize inbound commercial and business contracts, including vendor, procurement, professional services, SaaS/software, data-related, and other contracts. Advise stakeholders regarding contractual matters and interpret contractual language and related legal concepts while maintaining a nimble and responsive approach to managing risk within a scaling organization. Support clients to resolve third-party contract disputes and amend, enforce, or terminate contracts. Coach and manage contracts management team members with professional development, contract review, and escalations. Draft and maintain contract templates, clause library, playbooks, and policies to increase efficiency and mitigate risk. Coordinate internal compliance measures relating to business and legal policies, including preparing and conducting regular training sessions for other Contracts Team members and internal clients throughout the organization. Maintain up-to-date knowledge of applicable laws, regulations, and standards to ensure CZI's adaptation and compliance, including training others on the Contracts Team. Proactively contribute to general team and organizational operations, including taking on special projects and helping out with other functions, as necessary. What You'll Bring JD required and an active membership in at least one U.S. state bar, preferably California. Minimum of 7 years of relevant in-house and/or law firm experience with a focus on transactions, contracts management, and advising clients, preferably in fields relating to science and technology; management experience a plus. Strong verbal and written communication, analytical and social skills, and good judgment. Strong people management and collaboration skills, with a particular emphasis on working well in a team-oriented environment and servicing a broad range of constituencies. Ability to assess and manage risk in alignment with the organization's unique needs and to concisely advise clients of varying expertise and experience. A mission-driven mentality, with an interest in science and/or education philanthropy. Compensation The Redwood City, CA base pay range for a new hire in this role is $193,000 - $265,100. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Better Together As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. Provides a generous employer match on employee 401(k) contributions to support planning for the future. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. #LI-Hybrid

The Team Across our work in Science, Education, and within our communities, we pair technology with grantmaking, impact investing, and collaboration to help accelerate the pace of progress toward our mission. Our Central Operations & Partners team provides the support needed to push this work forward. Central Operations & Partners consists of our Brand & Communications, Facilities, Finance, Infrastructure/IT Operations/Business Systems, Initiative Operations, People, Real Estate/Workplace/Facilities/Security, Research & Learning, and Ventures teams. These teams provide the essential operations, services, and strategies needed to support CZI's progress toward achieving its mission to build a better future for everyone. Our Central Tech team provides technology and security support for CZI and our grantees. We believe that Engineering, IT and Security are most effective when in sync and learning from each other on a daily basis. Across our three pillars of Infrastructure, Security, and Grantee & Partner Support, we enable our teams to achieve their goals faster and more securely. We leverage technology to automate manual processes, constantly innovate to optimize operations, provide first-class support, and build solutions to enable the scale and execution of our business partners' strategies and initiatives. As an AI Integration & IT Application Administrator on the Central Tech team, you will work cross-functionally within CZI's Central Tech teams, and across the organization to deploy modern solutions that drive the work behind our mission. The Opportunity This AI Integration & IT Application Administrator role offers the exciting opportunity to drive technical unification across collaboration and productivity tooling at CZI and the Chan Zuckerberg Biohub. This is a highly cross-functional role focused on bringing AI technologies and integrated systems to life in a way that improves productivity and collaboration across the org. You'll work at the intersection of engineering, infrastructure, and IT administration. This is a growth-minded role with broad exposure, ideal for someone excited to help shape how AI tools and employee platforms come together. What You'll Do Build and launch AI-powered tools, agents, and internal workflows that support collaboration, decision-making, and operational efficiency across engineering, operations, and research teams Set up and manage AI development environments and automation tools and internal platforms that support prototyping, deployment, and scaling of AI solutions Partner with stakeholders to design and optimize AI workflows, including code assistants, secure API routing, GCP integrations, and custom processes Integrate external and internal systems into secure, auditable, and reliable toolchains Extend core collaboration platforms (Slack, Google Workspace, Atlassian) through lightweight automation and scripting (e.g., Google Apps Script, Slack Workflows, Jira Automation) Maintain shared systems for search, discovery, and cross-platform access that reduce time-to-knowledge and eliminate workflow fragmentation Support basic administration, scaling, and management of collaboration platforms with an emphasis on enabling autonomy and reducing operational overhead What You'll Bring Demonstrated experience designing and deploying AI-powered tools, including intelligent agents, search systems, and workflow automation at scale Proficiency with AI orchestration tools and frameworks multi-agent systems, and Model Configuration Platforms (MCPs) Strong proficiency with developer enablement platforms supporting internal prototyping, deployment, and integration Proficiency in Python, JavaScript, and API integration for building and automating end-to-end workflows across internal systems Familiarity with enterprise AI ecosystems such as Google, Anthropic, and OpenAI, and experience integrating these platforms securely and effectively Working knowledge of collaboration and productivity platforms such as Atlassian, Slack, and Google Workspace, including administration and support tasks Strong communication skills and comfort working across cross-functional teams to drive clarity and adoption Ability to balance experimentation and prototyping with long-term maintainability, management, and documentation Compensation The Redwood City, CA base pay range for this role is $158,000 - $217,800. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Work Mode As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Team CZI supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. Our vision is to build the future of science by leveraging advances in AI alongside biomedical research. Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems - paving the way for new discoveries that will change medicine in the decades that follow: Building an AI-based virtual cell model to predict and understand cellular behavior Developing state-of-the-art imaging systems to observe living cells in action Instrumenting tissues to better understand inflammation, a key driver of many diseases Engineering and harnessing the immune system for early detection, prevention, and treatment of disease CZI's work in science includes grantmaking programs, open-source software development, and close collaboration with the Chan Zuckerberg Biohub Network. The CZ Biohub Network includes the San Francisco, Chicago, and New York Biohubs as well as the Chan Zuckerberg Imaging Institute. CZI also collaborates with institutional partners like the Kempner Institute for the Study of Natural & Artificial Intelligence at Harvard University. Join us in accelerating science. The Opportunity This leadership opportunity offers a chance to lead CZI's ambitious effort to transform cell biology - shifting from 90% experimental and 10% computational work to the reverse ratio over the next decade. As initiative leader, you will guide the development of AI-driven virtual cell models that predict and generate novel cell states, leveraging CZI's significant investment in computational infrastructure (including a 1000 H100 GPU cluster) and unparalleled biological datasets. You'll devise and execute strategies to build generative AI models that learn the "accessible space" and predict cell types, structure, function, and dynamics-all while maintaining rigorous experimental validation and addressing biologically relevant questions that currently defy available methodologies. The leader will coordinate across multiple domains, from genomics to proteomics, integrating static and dynamic cellular data, establishing robust data standards, and fostering collaboration between computational and experimental teams. This position offers a rare opportunity to establish a new paradigm in biological research that will dramatically accelerate both our fundamental understanding of biology and the development of novel cell therapies, while ensuring these powerful tools remain accessible to the broader scientific community and our family of institutes as we make progress towards achieving our goals as a science philanthropy. The President of the Virtual Cell Models program will join our Science Leadership team, reporting to our Head of Science. What You'll Do Leadership & Vision Direct the overall scientific vision and strategy for the Virtual Cell Models program, including key decisions about key biological questions, model organisms, cell types, and the systems our organization will prioritize Build, lead and manage a major initiative within CZI, including recruiting and inspiring world-class scientists and engineers, organizing this initiative for optimal success, and driving teams to execute on multiple complex projects, often on accelerated timeframes Maintain scientific excellence across all data types and computational approaches used in this initiative Ensure integration of diverse biological data into cohesive, multi-scale models that advance understanding of cells and their function Develop clear roadmaps and timely plans for resource allocation, prioritization, and our strategic direction for building virtual cell models Foster innovation and collaboration across experimental and computational domains internally at CZI's institutes and externally with the science community Skillfully manage collaborations across multiple institutions, balancing immediate deliverables with long-term ambitious goals Effectively leverage CZI's compute infrastructure including a 1000 H100 GPU cluster to maximize scientific discovery and lead the development computationally driven biological research AI/ML × BIO Imperatives Guide the organization's data generation requirements, standards, and quality control processes in collaboration with cross-functional teams Effectively drive and coordinate projects between experimental and computational teams Drive the organization's approach to building, buying, and/or partnering with external collaborators to develop critical technologies Report progress against concrete milestones and deliverables to the broader organization, including the senior leadership team Strategic Accountability Serve as the intellectual owner of the initiative's direction and priorities Create the vision for how the Virtual Cell will transform biological research Build and maintain CZI's competitive differentiation and industry-leading position, and ensure its outputs advance understanding of human disease Skillfully communicate CZI's work and advancements externally as a public-facing spokesperson for the work Identify and develop strategic partnerships when beneficial Maintain a sharp focus on applications and opportunities to advance understanding of human disease What You'll Bring Ph.D. in Machine Learning, Computational Biology, or a related field with 20+ years of relevant experience Demonstrated background in AI/ML approaches to biological data analysis, including a deep understanding of diverse experimental methodologies across genomics, proteomics, and cell biology Significant scientific leadership experience overseeing cross-functional technical teams in academia and/or industry and facilitating strategic collaborations with partners in the field Proven track record of success in recruiting world-class talent, managing large teams and budgets efficiently and effectively, and delivering large-scale ML projects in computational biology or healthcare on time and within budget Deep expertise in modern deep learning architectures, particularly for multimodal data generation, integration, and standards, as well as biological sequence modeling Comprehensive understanding of cellular biology and experience working with complex biological datasets such as single-cell technologies and imaging analysis Exceptional communication, presentation, and interpersonal skills with the ability to inspire internal teams, collaborate, engage, and influence diverse stakeholders, and communicate Background in developing foundation models or large language models Track record of impactful research publications and patents Experience with high-performance computing, distributed systems, and cloud-based infrastructure Compensation The Redwood City, CA base pay range for a new hire in this role is $794,000.00 - $1,135,200.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Better Together As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Team CZI and its Biohub Network supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease. Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems - paving the way for new discoveries that will change medicine in the decades that follow: Building an AI-based virtual cell model to predict and understand cellular behavior Developing novel imaging technologies to map, measure and model complex biological systems Creating new tools for sensing and directly measuring inflammation within tissues in real time.tissues to better understand inflammation, a key driver of many diseases Harnessing the immune system for early detection, prevention, and treatment of disease Our work in science is focused on doing fundamental research to better understand human biology and building the tools and technology that move science forward to prevent disease and get to cures faster.. Join us in accelerating science. The Opportunity Join a dynamic team within CZI's Science Initiative focused on building user-facing applications that empower computational biologists and researchers through scalable, flexible, and intelligent workflows. This team plays a key role in accelerating scientific discovery by developing generalized tools that integrate machine learning services, human-in-the-loop capabilities, and customizable data processing. Our mission is to unify the diverse functionalities and resources available across the broader organization - from data services to inference pipelines - into a cohesive platform that supports both internal collaborators and the broader scientific community. Whether users are bringing their own datasets, leveraging CZI tools, or customizing their processing pipelines, this role offers the chance to shape how cutting-edge science is conducted . What You'll Do Design, develop, and maintain scalable full-stack web applications that power research workflows across scientific domains. Collaborate closely with scientists, product managers, and other engineers to build intuitive, flexible user interfaces and backend services. Integrate diverse services and tools - including ML inference pipelines, human-in-the-loop interfaces, and data management systems - into a cohesive platform. Ensure high standards of code quality, performance, and maintainability through code reviews, testing, and automation. Drive architectural decisions and contribute to long-term technical planning to support extensibility and scale. Build systems that enable researchers to bring their own data, customize processing, and adapt workflows to their unique needs. Partner with infrastructure and platform teams to ensure seamless deployment, observability, and operational stability of services. What You'll Bring 7+ years of professional experience developing full-stack web applications with modern front-end frameworks (e.g., React) and backend technologies (e.g., Node.js, Python). Proven ability to design and implement scalable APIs and data-driven applications. Expert knowledge of computer science, with strong competencies in data structures, algorithms, and software design. Familiarity with infrastructure concepts such as containerization (Docker), orchestration (Kubernetes), and CI/CD practices. Experience integrating or building around AI/ML services, especially in application layers involving inference or interactive AI tools. Nice-to-have: a background or familiarity with biology, computational biology, or scientific workflows or a strong interest in learning quickly about the field. A product mindset with attention to user experience, performance, and extensibility. Strong collaboration skills with a history of working cross-functionally with technical and non-technical stakeholders. Curiosity, flexibility, and a desire to work in a mission-driven, rapidly evolving environment. Compensation The Redwood City, CA base pay range for a new hire in this role is 190,000 - $261,800. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Better Together As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Chan Zuckerberg Initiative was founded in 2015 by Priscilla Chan and Mark Zuckerberg to help solve some of society's toughest challenges - from curing or preventing disease to improving education and addressing the needs of our local communities. We provide the operational support across our areas of work. The Team Across our work in Science, Education, and within our communities, we pair technology with grantmaking, impact investing, and collaboration to help accelerate the pace of progress toward our mission. Our Operations organization provides the support needed to push this work forward. Operations consists of our Brand & Communications, Central Tech, Finance, People, Real Estate/Workplace/Events/Facilities/Security (REWFS), Strategy & Operations, and Ventures teams. These teams provide the essential operations, services, and strategies needed to support CZI's progress toward achieving its mission to build a better future for everyone. Our AI, Infrastructure and Security team provides technology and security support for CZI and our grantees. We believe that Engineering, IT and Security are most effective when in sync and learning from each other on a daily basis. Across our three pillars of Infrastructure, Security, and Grantee & Partner Support, we enable our teams to achieve their goals faster and more securely. We leverage technology to automate manual processes, constantly innovate to optimize operations, provide first-class support, and build solutions to enable the scale and execution of our business partners' strategies and initiatives. The Opportunity As a Senior Security Software Engineer on the Central Tech team, you will focus on securing systems to enable the use of AI across the organization by making it safe and easy to incorporate more data and models. You will work on a collaborative multi-disciplinary team to identify risk/reward tradeoffs and build secure AI solutions. What You'll Do Design and implement secure-by-default infrastructure and services supporting AI/ML workloads. Collaborate with AI/ML engineers, data engineers, and platform teams to integrate security best practices. Develop or acquire tooling and automation to detect and mitigate vulnerabilities specific to AI environments (e.g., model poisoning, data leakage, adversarial attacks). Stay current on AI threat landscapes, compliance standards (e.g., NIST AI RMF, GDPR), and emerging security frameworks for AI/ML systems. Leverage and contribute to open source tools and technologies. Monitor for and respond to emerging threats to AI/ML systems, and participate in incident response and root cause analysis. Strong understanding of authentication, authorization, encryption, container security, and network security. What You'll Bring 5+ years of experience in software engineering with a focus on security. Proficiency in Python and at least one systems-level language (e.g., Go, Rust, or C++). Experience with securing cloud-based and on-prem AI infrastructure. A desire to automate systems to minimise human errors. Ability to work cross functionally across the organization. Nice to have - Background in privacy-enhancing technologies (e.g., differential privacy, federated learning, homomorphic encryption). Compensation The Redwood City, CA base pay range for a new hire in this role is $190,000-$261,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Team CZI supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease. Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems - paving the way for new discoveries that will change medicine in the decades that follow: Building an AI-based virtual cell model to predict and understand cellular behavior Developing state-of-the-art imaging systems to observe living cells in action Instrumenting tissues to better understand inflammation, a key driver of many diseases Engineering and harnessing the immune system for early detection, prevention, and treatment of disease CZI's work in science includes grantmaking programs, open-source software development, and close collaboration with the Chan Zuckerberg Biohub Network. The CZ Biohub Network includes the San Francisco, Chicago, and New York Biohubs as well as the Chan Zuckerberg Imaging Institute. CZI also collaborates with institutional partners like the Kempner Institute for the Study of Natural & Artificial Intelligence at Harvard University. Join us in accelerating science. Our Central Tech team provides technology and security support for CZI and our grantees. We believe that Engineering, IT and Security are most effective when in sync and learning from each other on a daily basis. Across our three pillars of Infrastructure, Security, and Grantee & Partner Support, we enable our teams to achieve their goals faster and more securely. We leverage technology to automate manual processes, constantly innovate to optimize operations, provide first-class support, and build solutions to enable the scale and execution of our business partners' strategies and initiatives. The AI/ML Infrastructure team works on building shared tools and platforms to be used across the Chan Zuckerberg Initiative, partnering and supporting the work of an extensive group of Research Scientists, Data Scientists, AI Research Scientists, as well as a broad range of Engineers focusing on Education and Science domain problems. Members of the shared infrastructure engineering team have an impact on all of CZI's initiatives by enabling the technology solutions used by other engineering teams at CZI to scale. The Opportunity We are seeking a Senior Director of Engineering to lead our infrastructure organization spanning AI infrastructure engineering, AI/ML operations, data infrastructure, cloud infrastructure, and security engineering. This leader will drive strategy, execution, and innovation to support AI research, web products, and production workloads across hybrid environments (cloud and on-prem HPC). This team manages the largest cluster for scientific research in the world with more than 1,300 GPUs (NVIDIA H100 and H200 GPUs) and enables scientific research and development of various biological models (like GREmLN, TranscriptFormer) from vast biological datasets acquired through our BioHub labs, partnerships and open science repositories. The role is highly cross-functional, partnering closely with product, research, and operations teams to deliver scalable, secure, and high-performing systems. What You'll Do Define and execute the long-term vision and roadmap for AI, data, cloud, and security infrastructure, with clear metrics to measure progress and outcomes. Oversee the design and operation of hybrid GPU compute clusters and ML platforms to support training, fine-tuning, and inference workloads. Ensure robust, scalable, and efficient data infrastructure and cloud operations to power analytics, ML pipelines, and product needs. Drive reliability, observability, and cost optimization across GPU based workloads for development, training and inference. Implement modern AI/ML Ops practices (orchestration of model training workloads, reproducibility, automated monitoring) to accelerate research and production workflows, with a focus on continuous delivery and improvement. Build, mentor, and scale high-performing, multi-disciplinary engineering teams. Partner with product, research, and executive leadership to align infrastructure with organizational priorities, ensuring delivery is measured against agreed objectives and key results. Establish policies for infrastructure usage, prioritization, and compliance with regulatory requirements. Stay ahead of emerging technologies in AI infrastructure, cloud, and security; drive their strategic adoption. What You'll Bring 15+ years in engineering, with at least 7+ years in senior leadership roles managing multi-disciplinary teams and organizations of 30+ employees, with experience leading and developing managers Strong knowledge of AI/ML frameworks (e.g., PyTorch) and MLOps tools (e.g., Kubeflow, MLflow, Ray). Experience managing both traditional cloud platforms (AWS, GCP, Azure) and AI cloud (HPC/GPU clusters). Deep experience with large-scale data systems, pipelines, and storage technologies. Track record of improving reliability, observability, and cost efficiency in large-scale systems. Proven ability to define multi-year infrastructure strategies while delivering on immediate priorities. Exceptional written and verbal communication skills, capable of engaging technical and non-technical audiences. Ability to provide clear leadership and momentum in an ambiguous environment-setting direction, aligning teams, and turning uncertainty into forward progress. Compensation The Redwood City, CA base pay range for a new hire in this role is $435,000 - $621,500. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Pay ranges outside Redwood City are adjusted based on cost of labor in each respective geographical market. Your recruiter can share more about the specific pay range for your location during the hiring process. Work Mode As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid

The Team Across our work in Science, Education, and within our communities, we pair technology with grantmaking, impact investing, and collaboration to help accelerate the pace of progress toward our mission. Our Central team provides the support needed to push this work forward. The Central team at CZI consists of our Finance, People, Real Estate, Events, Workplace, Facilities, Security, Brand & Communications, Business Systems, Central Operations, Strategic Initiatives, and Ventures teams. These teams provide strategic support and operational excellence across the board at CZI. The Opportunity By pairing engineers with leaders in our science and education teams, we can bring AI/ML technology and Data to the table in new ways to help drive AI powered solutions that accelerate Biomedical research and improvements in the Education space. We are uniquely positioned to design, build, and scale software systems to help educators, scientists, and policy experts better address the myriad challenges they face. We are supporting researchers and scientists around the world by developing the capacity to apply state-of-the-art methods in artificial intelligence and machine learning to solve important problems in the biomedical sciences. The Data Engineering and Infrastructure team works on building shared tools and platforms to be used across the Chan Zuckerberg Initiative, partnering and supporting the work of an extensive group of Research Scientists, Data Scientists, AI Research Scientists, Computational Biologists, as well as a broad range of Engineers focusing on Education and Science domain problems. Members of the shared infrastructure engineering team have an impact on all of CZI's initiatives by enabling the technology solutions used by other engineering teams at CZI to scale. What You'll Do Develop and maintain the tooling and infrastructure that drives the entire data lifecycle at CZI, from ingestion and processing to secure storage and access. Your work will directly support cutting-edge research, AI model training, and data analysis across the organization. Partner with researchers and engineers across various domains, including genetics, imaging, and scientific literature. You'll work on various use cases, from web analytics to complex model training, ensuring data accessibility and performance for teams across CZI. Design and implement flexible, scalable, and performant systems to address our stakeholders' needs, leveraging technologies like Argo Workflows and Spark for mass-scale job processing and orchestration; Vast Data, Delta Lake, and Apache Iceberg for data management and access; and cloud and on-prem HPC resources What You'll Bring Education & Experience: BS, MS, or PhD in Computer Science or a related technical discipline, or equivalent experience. 7+ years of hands-on coding experience in scripting (Python, PHP, Ruby) and systems languages (Rust, C++, C#, Go, Java, or Scala). Data Platform Expertise: Proficiency in managing large-scale data operations, including designing scalable pipelines (streaming and batch), working with varied data types, and optimizing flexible storage solutions using tools like Argo Workflows, Spark, Delta Lake, and Apache Iceberg Data Management and Development Operations: Experience with data governance, metadata, and data lineage tooling like Open Lineage or Marquez. Deep experience working with building CI/CD pipelines for data infrastructure and associated observability and monitoring tooling such as Prometheus, Grafana, OpenTelemetry, Prometheus, or Honeycomb Supporting Complex Data and AI ML Workflows: Experience with addressing end to end data needs for working with complex data and delivering this data ready form model training, working directly with AI Researchers and AI Engineers as part of AI model training project teams. Knowledge of data pipelines that feed Deep Learning model training that makes use of accelerated computing systems (GPUs as well as ASICs, FPGAs, TPUs) Containerization: Extensive experience with scaling containerized applications on Kubernetes or Mesos, with a focus on secure custom containers, replicability and portability. Cloud & Infrastructure: Strong experience with AWS, GCP, or Azure. Exposure to hybrid environments with on-prem and colocation systems is a plus. Familiarity with Infrastructure as Code (e.g., Terraform, Ansible) and monitoring tools (Datadog, Prometheus). Collaboration & Problem Solving: Proven ability to work with diverse, cross-functional stakeholders and teams to navigate complex technical challenges, adapt to evolving requirements, and drive impactful solutions. Compensation The Redwood City, CA base pay range for a new hire in this role is $214,000-$294,800. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. As we grow, we're excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team's manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process. Benefits for the Whole You We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. CZI provides a generous employer match on employee 401(k) contributions to support planning for the future. Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs. CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them. Paid time off to volunteer at an organization of your choice. Funding for select family-forming benefits. Relocation support for employees who need assistance moving to the Bay Area And more! If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. Explore our work modes, benefits, and interview process at ******************************* #LI-Hybrid