Doctoral Fellow jobs at City of Hope - 23 jobs

Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions. Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Postdoctoral researcher opportunity is available in the laboratory of Dr. Zhen Bouman Chen, a leading expert in the field of vascular biology and diabetes complications and Co-Director of the Cardiovascular Research Center at the Arthur Riggs Diabetes Metabolism Research Institute of City of Hope. Built upon her interdisciplinary training in medicine, vascular biology, bioengineering, and data science, Dr. Chen leads an active research program focused on epigenetics, RNA and chromatin biology and endothelial stress response. Her team integrates innovative high-throughput sequencing technologies, bioinformatics approaches, and multi-scale models to elucidate RNA-mediated endothelial biology in the context of diabetes. Dr. Chen is passionate about mentorship and peer support and Chairs the Women Leadership Committee of the Arteriosclerosis, Thrombosis, and Vascular Biology Council of the American Heart Association. For more information on Dr. Chen's research please visit here. As a successful candidate, you will: * Work on NIH and other externally or internally funded projects with a focus on vascular biology, diabetes (and its complications), and/or cancer. * Work with the PI and other team members (including bioinformaticians, bench scientists, statisticians, and physician scientists) to perform experiments using cell culture, animal models, and human tissues, conduct bioinformatics analysis for high-throughput sequencing data, and report research findings in scientific publications and oral/poster presentations at select scientific conferences. * Be strongly encouraged to apply intramural or extramural funding for career development. Your qualifications should include: * A M.D. and/or Ph.D. degree in life sciences * Preferred experience in one or more areas of the following: mouse handling and metabolic phenotyping, microsurgery skills (e.g., dissection, ligation, suture), vascular/endothelial biology, stem cell biology, RNA/chromatin biology, immunohistochemistry, immunology, sequencing analysis and bioinformatics, flow cytometry and imaging-based analyses, tissue processing, 3D/organoid culture, and nanomedicine. * Preferred research in one or more of these areas: cardiovascular, metabolic, and neurodegenerative diseases, cancer, or aging. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the transformative team at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. City of Hope's growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and treatment facilities in Atlanta, Chicago and Phoenix. Our dedicated and compassionate employees are driven by a common mission: To deliver the cures of tomorrow to the people who need them today. The laboratory of Dr. Adam de Smith in the Department of Pediatrics is looking for a highly motivated Postdoctoral Fellow to study the etiology and early-life origins of childhood acute leukemia. The de Smith lab uses molecular and epidemiological methodologies to advance our understanding of the germline genetic risk, somatic drivers, and early-life origins of childhood leukemia, with the goal of developing strategies for disease prevention. You will have opportunities to analyze large-scale germline genotyping data, as well as tumor whole-genome sequencing data from childhood leukemia patients to investigate the etiologic role of early-life environmental exposures and the prenatal origins of childhood leukemia, for example in our ReCord Study (************************ Applicants are required to submit a CV accompanied by a cover letter outlining how your career objectives align with the research conducted in our lab. Please indicate the expected graduation date if applicable. Your CV should include a detailed list of preprints/publications, along with the names and contact information of three potential referees. Your qualifications should include: * A Ph.D. degree in genetics, genetic epidemiology, biological sciences, or a related discipline is required. * Excellent oral and written communication skills. * Proficiency in one or more programming languages is essential. * Evidence of productivity reflected in first author publications in peer-reviewed journals. Ability to conduct independent research and work effectively in a team. * Experience in conducting human genetics research and analyzing large genetic datasets is preferred. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. The Beckman Research Institute of City of Hope invites applications for a talented Postdoctoral Fellow to join our dynamic research team. As a Postdoctoral Fellow, you'll have the opportunity to work on cutting-edge projects that contribute to the advancement of medical science and have a direct impact on patient outcomes. Your qualifications should include: * Ph.D. degree in life or biomedical sciences, or a related discipline is required. * Proven track record of successful research projects and publications. * Excellent analytical and problem-solving skills. * Effective communication and collaboration abilities. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow. This position will be in the laboratory of Dr. Helena Reijonen within the Department of Immunology and Theranostics of the Art Riggs Diabetes & Metabolism Research Institute. Dr. Reijonen's research is focused on characterization of autoimmune-mediated Type 1 Diabetes. The lab seeks to identify autoreactive T lymphocytes in the blood of individuals with T1D and to understand the specific features of these cells, how they are activated and how they can be regulated. In this regard, the primary goal of this research is to discover novel "signatures" of autoreactive T cells and pathways leading to autoimmunity. The lab also focuses on extracellular vesicles as a means of communication between immune cells and pancreatic islets. The insights gained are employed to enhance disease prediction and monitoring and evaluate effectiveness of therapy. As a successful candidate, you will: * Design and perform experiments and analyze data * Regularly communicate and interact with the other team members * Submit abstracts to scientific meetings, present and discuss research findings * Write and submit manuscripts for publication * Write and submit grants Your qualifications should include: * Ph.D. or M.D. degree in biomedical sciences, or a related discipline * Experience in tissue culture, cellular and molecular biology, and related methodologies * Experience of advanced multi-parameter flow cytometry, cell imaging and data analysis * Experience in statistical methodologies * Excellent written and verbal communication skills * Publications in peer-reviewed journals * Good problem-solving and time management skills, ability to design and conduct independent research, learn new techniques, knowledge of the literature, critical interpretation of data and clear data presentation, ability to work efficiently in a team and with collaborators * Experience in Single Cell Multi-omics techniques and multiple component analysis programs is an advantage * Previous experience in immunology research is an advantage City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. The laboratory of Dr. Yanzhong Yang in the Department of Cancer Genetics and Epigenetics at the Beckman Research Institute of City of Hope Cancer Center is looking for a highly motivated postdoctoral fellow to study transcriptional regulation and RNA metabolism in normal development and human diseases, such as neurological disorder, immunology, and cancer. In particular, the Yang lab utilizes biochemistry, molecular biology, CRISPR-based genomic screen, single-cell transcriptomics, and genetically modified mouse models to investigate the role of protein arginine methylation in the regulation of chromatin biology, RNA splicing, and RNA modification in mammalian cells. The ideal candidate should have extensive experience in biochemistry, molecular biology and cell biology. Skills in common RNA biology, epigenetics, and mouse models are preferred. The candidate should be self-motivated, with a proven track record of productivity. For more information about Dr. Yang lab, please visit here. Your qualifications should include: * A PhD in Biochemistry, Molecular and Cellular Biology, or related area. * Strong interest in basic and translational research. Strong work ethic, meticulous and detail-oriented record keeping habits. * Evidence of productivity reflected in first author publications in peer-reviewed journals. Ability to conduct independent research and work effectively in a team. Preferred qualifications: * Experience in handling mouse models. * Experience in neuroscience or immune oncology. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE. #PD

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Postdoctoral Fellowship position is readily available in the laboratory of Dr. Wendong Huang in Arthur Riggs Diabetes and Metabolism Research Institute at City of Hope. You will work on projects investigating the new pathways and targets in diabetes/obesity and cancer. The lab uses genetically engineered mouse models and molecular pharmacology tools to identify novel signaling pathways to develop new targets for drug discovery. Our research interests include: 1) Liver-gut and microbiota crosstalk as metabolic mediators in regulating both normal physiology and pathogenesis. 2) Development of novel drugs to treat MASH, diabetes, and cancer. For more information on Dr. Wendong Huang's research, please visit here. Your qualifications should include: * A Ph.D. or M.D. degree in broad biomedical sciences. * Proficiency in biochemical techniques, molecular biology skills, and cell culture. * Research experience with in vivo animal models. * Evidence of scientific rigor and excellence as documented by peer-reviewed publications. * Good communication skills and fluency in English, both spoken and written. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. The laboratories of Dr. Le Xuan Truong Nguyen in the Department of Hematological Malignancies and Translational Sciences are seeking highly motivated and innovative Postdoctoral Fellow. This is an excellent opportunity to join a well-established team and lead projects that culminate in publications in high-impact journals. Our research focuses on drug development, uncovering basic mechanisms, and identifying novel therapeutic targets in leukemogenesis and solid tumors. Specifically, we study genetic and epigenetic biomarkers with prognostic value in acute myeloid leukemia (AML) and other solid cancers. Our work emphasizes therapeutic candidates targeting mitochondrial vulnerabilities, including nucleoside analogs, small GTPase inhibitors, natural plant extracts, and immunotherapies. As a successful candidate you will: * Performing experimental procedures * Manage data, analyze, and report findings * Write scientific papers * Work with PI and other team members to perform experiments in vitro and in vivo * Utilize the following in vitro skills (not limited to but including): o Aseptic techniques, cell culture, western blot, RNA/DNA extraction, protein extraction, RT-qPCR, seahorse, northern blot, bacterial transformation, cloning, lentivirus production, etc. * Utilize the following in vivo skills (not limited to but including): o Basic routes of administration (oral gavage, intraperitoneal, retro-orbital, subcutaneous, intra-venous injections), blood collection, organ harvesting (spleen, bone marrow, liver, etc.) Your qualifications should include: * A Ph.D. degree in life or biomedical sciences, or related discipline is required. * Preferred experience in molecular signaling, cancer biology, leukemia research, and extensive murine studies. * Experience in immunology is an advantage. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE. #PD

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A postdoctoral position is open in the laboratory of Yingfeng Deng in the Department of Diabetes and Cancer Metabolism at the City of Hope Beckman Research Institute. The Deng laboratory studies the homeostasis of uridine and its role in metabolism, which provides a new angle for understanding the pathophysiology of obesity, diabetes and cancer. Work in the lab utilizes both genetically engineered mouse models and in vitro systems. A combination of state-of-the-art surgical, genetic, cellular, biochemical, imaging, and metabolic flux approaches is currently used in the lab. Following up with the new paradigm revealed about uridine metabolism by Drs. Deng and Scherer (Science, 2017), the Deng lab is currently focusing on three areas: 1) the role of uridine in the progression of obesity and diabetes. 2) the physiology of uridine in bile and nutrient absorption. 3) the regulation of uridine homeostasis by ER stress and its relevance to breast cancer. We seek an independent and highly motivated candidate interested in studying the molecular, cellular, and metabolic mechanisms leading to obesity, diabetes, and cancer. Expertise in using mouse models to study metabolic diseases is preferred. For a complete list of Publications please visit here: ********************************************************************** Your qualifications should include: * Ph.D. and/or M.D. degree in life or biomedical sciences or a related discipline is required. * Experience in basic molecular biology skills. * Experience in animal models and lipid metabolism. * Experience in metabolomics and liver physiology. * To Apply, please attach a cover letter describing your past training and research interests, a detailed CV and contact information of three referees City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. The Nath lab is seeking applicants for a postdoctoral position in computational cancer biology. Our lab aims to enhance cancer treatment outcomes through two main research areas: * Investigating the biological mechanisms underlying tumor progression: We use single-cell and bulk multiomic techniques to profile tumor samples, focusing on resistance mechanisms in breast cancer, glioblastomas, colon cancer, and lung cancer. * Advancing precision oncology through machine-learning models: We integrate multimodal patient data, including multiomic data and health record information, to develop predictive models for drug response. Furthermore, we work on creating new treatment stratification methods to personalize treatment for individual patients. More information about the lab can be found here: *********************** As a successful candidate, you will: * Collaborate closely with experimental scientists, mathematicians, and medical oncologists/surgeons to plan, design, and execute computational analyses. * Advance the integration of multi-omics and clinical datasets to uncover mechanisms of tumor evolution, therapeutic resistance, and potential biomarkers. * Contribute to the development of data analysis pipelines and software tools as a key aspect of this role. * Stay updated on the latest advancements in bioinformatics and genomics research and present findings to internal teams and external stakeholders, while also publishing research outcomes and presenting at conferences. * Work with the PI to develop a career development plan and participate in various career advancement opportunities. Your qualifications should include: * Ph.D. in bioinformatics, computational biology, or genetics. * Applicants with a wet lab background who are highly motivated to receive training in computational biology are also welcomed. * Strong fundamentals in cancer biology and basic statistics are essential. * Applicants are encouraged to demonstrate proficiency in programming languages like Python/R and omic data analysis. * Experience with machine learning algorithms is advantageous. Additional Information: * Applicants are required to submit a CV accompanied by a cover letter outlining how their career objectives align with the research conducted in our lab. Please indicate the expected graduation date if applicable. * The candidate's CV should include a detailed list of preprints/publications, along with the names and contact information of three potential referees. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE. #PD

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Postdoctoral Fellowship position is available immediately in the dynamic Department of Immuno-Oncology at the Beckman Research Institute, City of Hope. This role offers an exciting opportunity to investigate immune checkpoint signaling within the tumor microenvironment and contribute to the development of novel anticancer therapies. The project involves both in vitro and in vivo studies to uncover the molecular and cellular mechanisms driving cancer-associated immunosuppression using mouse and human solid tumor models. Additionally, the selected candidate will advance ongoing correlative studies by analyzing immune markers of response in clinical samples. For more information about Dr. Kortylewski's lab, please visit the Kortylewski Lab Website. Your qualifications should include: * Ph.D. degree in life or biomedical sciences, or a related discipline is required. * Strong background in molecular biology and/or tumor immunology. * Experience in immunophenotyping of human and mouse immune cells using flow cytometry and functional assays, * Candidates with strong expertise in tumor immunology and animal studies, who have earned their Ph.D. within the past 1-2 years, are encouraged to apply. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity, and inclusion, please click here.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Postdoctoral Fellow position is available in the laboratory of Dr. Sangeeta Dhawan, at the Arthur Riggs Diabetes and Metabolism Research Institute. We are looking for a postdoctoral fellow interested in studying the epigenetic regulation of pancreatic beta-cell mass in health and diabetes. Our lab's primary focus is understanding beta cell failure from a developmental perspective. We are interested in the dynamics of beta-cell heterogeneity, islet organization and cell-cell interaction in fetal and neonatal development. The Dhawan lab utilizes genetic mouse models, molecular biology, imaging and epigenetic techniques to study the cellular identity, function, remodeling, and survival of beta-cells in physiological and pathological conditions. For more information on Dr. Dhawan and her research please visit here. As a successful candidate, you will: * Have a willingness to learn and establish new methodologies and research directions * Have extensive experience in molecular biology and rodent models * Have experience with epigenetic techniques Your qualifications should include: * PhD in Molecular, Cellular or Developmental Biology. * Strong interest in diabetes research. * Extensive experience with basic molecular biology skills. * Extensive experience in handling animal models. * Experience with tissue collection, histology, immunohistochemistry, and cell sorting. * Experience with cell culture, immunofluorescence, and flow cytometry. * Experience with epigenetic and single cell methods preferred. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Postdoctoral Fellowship position is available in the Vaccine Research Laboratory of Dr. Don Diamond in the Department of Hematology & Hematopoietic Cell Transplantation. Dr. Diamond's research team is seeking a highly motivated candidate with skills and understanding in antigen presentation utilizing bioinformatics tools to be applied to vaccine development utilizing viral vectors to contribute to an effort in developing neoantigen expressing vaccines for clinical investigations. The position is available as part of a multi-disciplinary research project to develop a neoantigen-based cancer vaccines to support an IND utilizing a highly efficient and fully synthetic poxvirus-vectored vaccine platform that has been derisked by its use in Phase 2 clinical trials as a Covid-19 vaccine (see NCT04977024, NCT05672355, and NCT04639466). Please refer to these publications for further background: doi:10.3390/vaccines11091492, PMC7705736, PMC8906816, PMID33257686, PMID31739399 describing the platform and earlier publications using a p53-expressing MVA as a clinical therapeutic in cancer patients (10.1158/2767-9764.CRC-23-0394, PMC8802616, PMC5856606, and PMC5706612). As a successful candidate you will: * Have experience and knowledge of human and murine immunology, selection tools for predicting immunologic epitopes complementing virology skills (poxvirus molecular biology) * Develop and characterize recombinant vaccine vectors incorporating neoantigens identified by proprietary bioinformatic pipelines and test these vaccine candidates for in vivo immunogenicity and protective efficacy in different animal tumor models leading to early phase clinical trials in pancreas, lung, and bladder tumor patients. The goal of these efforts is a start-up company utilizing GMP manufacturing to produce neoantigen vaccines for patients at medical centers nationally as a primary goal. Your qualifications should include: * PhD degree in an appropriate discipline such as cellular or tumor immunology or related fields * Interest and knowledge in vaccine research (poxvirus especially) and neoantigen-based vaccine methods utilizing bioinformatics epitope selection pipelines. * Experience in molecular virology methods, and antigen presentation and processing as applied to human and murine oncology. * Ability to independently document scientific progress and write research articles. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Postdoctoral Fellowship opportunity is immediately available for the highly motivated individual in the laboratory of Dr. Alberto Pugliese, MD in the AR-DMRI Department of Diabetes Immunology. The research is highly translational and primarily focused on human type 1 diabetes. The major ongoing projects are investigating mi RNA biomarkers, pancreas pathology, and novel therapeutics, also in the context of the analysis of live pancreas tissue from organ donors obtained from the Network for Organ Donors with Diabetes (nPOD), of which Dr. Pugliese is Executive Co-Director, and in future clinical trials. Upcoming studies are projected to include the analysis of samples from patients with type 1 diabetes participating in clinical trials, with trials expected to start in late 2023 and 2024. Additional studies involve analysis of samples from recipients of pancreas-kidney transplant in the context of recurrent type 1 diabetes. As a successful candidate, you will: * You must have experience with flow cytometry, molecular biology techniques, cell culture, microscopy, tissue processing, immunohistochemistry, immunofluorescence, data analysis (gene expression data, flow cytometry data, etc). While our research is primarily focused on human specimens, animal studies are used on occasion. Your qualifications should include: * PhD or M.D. * Pre-doctoral experience/training in type 1 diabetes research desirable but not an absolute requirement * Familiarity with computer software (Word, PowerPoint, Excel, databases) and basic statistical principles Additional Information: * For more information on nPOD please visit here: ***************** * For more information on the Arthur Riggs Diabetes & Metabolism Research Institute please visit here: *********************************************************************************** * For more information on The Wanek Family Project for Type 1 Diabetes please visit here: ******************************************************************************************* City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. The Beckman Research Institute of City of Hope is looking for talented Postdoctoral Fellows in Cancer Genomics and Biology to join Dr. Zhaohui Gu's laboratory. Dr. Gu's laboratory investigates molecular markers that define high-risk B-cell acute lymphoblastic leukemia (B-ALL) subgroups and elucidates their biological functions. The group integrates bulk and single-cell genomics, transcriptomics, and epigenomics with mechanistic studies using in vitro and in vivo models to dissect B-ALL and related hematologic malignancies. The lab also studies normal hematopoietic stem and progenitor cells and the bone marrow microenvironment, which provides essential context for understanding leukemia initiation, clonal evolution, and therapy response. For more information about Dr. Gu's lab and research, please visit: ****************** and ************************************* As a successful candidate, you will: * Design and execute experiments to understand the molecular functions of driver genetic lesions in high-risk leukemia subtypes. * Perform high-throughput sequencing-based assays to systematically characterize leukemic and normal hematopoietic cells. * Interpret multi-omics datasets in close collaboration with computational team members. * Use knock-in and xenograft mouse models to study leukemogenesis, clonal evolution, leukemia-niche interactions, and drug responses. * Troubleshoot experiments, maintain accurate records of methods and results, and contribute to rigorous and reproducible research practices in the lab. * Present results in internal seminars and external conferences and contribute to the writing of manuscripts. Your qualifications should include: * Ph.D., M.D., or M.D./Ph.D. in a relevant field, for example Biology, Medicine, Bioinformatics, Computer Science, Engineering, Immunology, Hematology, Genomics, Bioinformatics, or a closely related discipline. * Strong publication record that demonstrates expertise in at least one of the following areas: * Hematology * Leukemia or other hematologic malignancies * Cancer genomics, transcriptomics or epigenomics * Hands-on experience with core molecular and cellular biology techniques and standard biochemical assays. * Excellent written and oral communication skills and the ability to work effectively in a collaborative team environment. Preferred qualifications: Candidates with one or more of the following will be viewed favorably: * Experience with functional genomics or epigenomics platforms or single-cell technologies (sc RNA-seq, sc ATAC-seq, CyTOF). * Familiarity with analysis of high-throughput sequencing data and interest in learning or applying computational tools for leukemia genomics. * Background in classification or biomarker studies, especially for leukemia or other hematologic malignancies. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE. #PD

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. The Jianjun Chen Lab at City of Hope is looking for talented Postdoctoral Fellows to study cancer and stem cell biology. There are multiple openings available within this lab. The research group is interested in studying DNA/RNA-mediated epigenetic, transcriptional, and post-translational regulation of gene expression related to normal hematopoiesis, leukemogenesis, and tumorigenesis as well as developing new targeted therapies for hematological malignant diseases and cancers. Our research involves experiments with various biochemistry and molecular techniques, genomic approaches, and genetic and xenograft mouse models. For more information on the research lab please visit here. As a successful candidate you will: * Design and conduct of experiments related to current projects * Analyze primary data * Prepare manuscripts and other research presentations. Your qualifications should include: * PhD or M.D. in life or biomedical sciences or a related discipline * Extensive experience with techniques in hematological research, molecular biology, biochemistry or mouse genetics. * Experience with mammalian cell culture, molecular cloning, flow cytometric analysis, multiple-omics analysis, bioinformatics, and animal experiments is preferred. * Be highly motivated individuals who can work in a team environment. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A postdoctoral scientist position is available in the laboratory of Dr. Xiaolan Deng at City of Hope. Our group is interested in discovering novel genetic and epigenetic regulations and deciphering their underlying molecular mechanisms in normal developmental processes and tumorigenesis. We cover research areas with relevance to RNA Biology, Cancer Biology, Chromatin Regulation, Cancer Epigenetics, Epigenetics Regulation, Cancer Metabolism, Immunology, Drug Discovery, Development, and Structural Biology, with an emphasis on RNA epigenetics/epitranscriptomics (RNA modifications) and RNA-based therapeutics. Our research involves experiments with RNA Biology, RNA modifications/editing, mRNA-based therapeutics, primary human cancer cells, cancer and stem cell transplantation models, mouse genetics, molecular biology, biochemistry and cell biology, chemical biology, immunology, functional genomics, signal transduction, single-cell sequencing, spatial sequencing, metabolism, drug development, structural biology, and large-scale data analysis and computational biology. For more information about Dr. Deng's lab, please visit here. As a successful candidate, you will: Work with a range of techniques, including but not limited to: * Flow cytometry, mass spectrometry/quantitative phospho-profiling, CyTOF, mouse genetics models, xenograft assays, retroviral gene delivery, chemical biology, drug development, whole exome sequencing and RNA-seq-analysis of clonal evolution of cancer, dot blots, RNA modification-seq, ChIP-seq, RIP-seq, PAR-CLIP-seq, and pre-clinical drug testing in xenotransplantation models, etc. Your qualifications should include: * A Ph.D. and/or M.D. degree(s), and a solid background in RNA biology, RNA modifications/editing, epitranscriptomics, chromatin remodeling, mRNA-based therapeutics, drug discovery, drug delivery, biochemistry, chemical biology, development, epigenetics, immunology, tumor immunity, tumor microenvironment, pathology, metabolism, structural biology, and/or stem cell research. * Mouse model research experience is a plus. * The candidates should be highly motivated individuals with the ability to work in a team environment and with good oral and written communication skills in English. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE. #PD

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Postdoctoral Research Fellow position is open under Dr. Nagarajan Vaidehi within the department of Computational and Quantitative Medicine. This project involves the development and application of interpretable machine learning methods to uncover allosteric regulation of disordered regions in the dynamics of G-protein coupled receptors to enable design of allosteric modulators. You will work on developing design principles of targeted protein degradation in collaboration with Pharma. For more information on Dr. Vaidehi's lab please visit here. Your qualifications should include: * PhD or M.D. in Chemistry, Physics or Biochemistry with experience in protein dynamics studies. * Knowledgeable about concepts in statistical thermodynamics, in python scripting and C++ programming. * Familiarity with Molecular Dynamics methods and experience in code development is preferred. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A postdoctoral research fellow position in the department of Computational and Quantitative Medicine. For more information about Dr. Vaidehi's lab, please visit here. As a successful candidate, you will: * This project with Dr. Nagarajan Vaidehi involves developing and application of interpretable machine learning methods to uncover allosteric regulation of disordered regions in the dynamics of G-protein coupled receptors to enable design of allosteric modulators. * The candidate will also work on developing design principles of targeted protein degradation in collaboration with Pharma. * Successful applicants will also have an opportunity to participate in a multidisciplinary research environment. Your qualifications should include: * Ph.D. degree in Chemistry or Physics or Biochemistry with experience in protein dynamics studies. * The candidate should be knowledgeable about concepts in statistical thermodynamics, in python scripting and C++ programming. Preferred qualifications: * Familiarity with Molecular Dynamics methods and experience in code development is preferred. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE. #PD

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. Led by Dr. Ajay Goel, Professor and Founding Chair of the Department of Molecular Diagnostics and Experimental Therapeutics, our multidisciplinary research group comprises basic researchers, gastroenterologists, surgeons, oncologists, and bioinformaticians, undertaking several collaborative projects involving large international consortia. This position has the potential to become tenure-track upon the receipt of grant funding lasting 3-5 years from a federal agency. Our research focuses on translational studies of the genomic and epigenomic characterization of various gastrointestinal cancers (GI), including colorectal, pancreatic, gastric, esophageal, and hepatocellular cancers. Our group performs cutting-edge research in GI oncology, is very productive, and publishes in high-impact journals such as Nature Cancer, Nature Communications, Nature Biotechnology, Nature Reviews Gastroenterology and Hepatology, New England Journal of Medicine, CA: A Journal for Clinicians, Gastroenterology, Cancer Cell, PNAS, JAMA Oncology, JNCI, Cancer Research, Clinical Cancer Research, , Annals of Surgery, etc. For more information on Dr. Goel's research, please visit here. If you are passionate about some of the following things we are working on this may be the perfect opportunity: * Development of cell-free DNA (mutation and methylation), RNA, and exosomal-based liquid assays for early cancer detection, prognosis, and predictive responses to chemotherapies and targeted drugs. * Studying the genetic and epigenetic basis of GI cancers (e.g., aberrant DNA methylation, histone modifications, and non-coding RNAs). * Understanding the biological implications of gut microbiome and its translational application is gastrointestinal cancers * The genetic basis of early-onset colorectal cancer (EO-CRC) and familial/hereditary colorectal cancer. * The role of extracellular vesicles/exosomes in cancer pathogenesis and their role as disease biomarkers. * The role of the tumor microenvironment, stem cells, immune regulation, and identification of novel targeted therapies. * Cancer prevention and adjunctive role of natural and integrative therapy approaches. As a successful candidate, you will: * Devise, plan, document, and advance basic science and translational projects in genetics, epigenetics, and precision oncology of gastrointestinal cancers. * Generate data for grant applications and prepare manuscripts for publication. * Work closely with other team members and external collaborators, including presenting progress internally or externally. * Ability to work in a fast-paced team environment and handle multiple projects simultaneously. Your qualifications should include: * Ph.D., MD, or MD/Ph.D., with a strong background and profound knowledge in oncology, cancer biology, immunology, or immunotherapy. * Ability to work in a fast-paced research environment and manage multiple projects and collaborations. * Previous experience working with human specimens and developing novel, innovative cancer biomarkers. * Evidence of scientific rigor and excellence as documented by high-impact peer-reviewed publications. * Strong team player with excellent communication skills and fluency in spoken and written English. * A strong track record of relevant original, peer reviewed publications, as a first author. * The individual must have effective skills in oral and written communication, teamwork, and problem-solving and be adaptable to changes in technological and scientific directions. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.