Staff Scientist jobs at City of Hope - 40 jobs

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. Led by Dr. Ajay Goel, Professor and Founding Chair of the Department of Molecular Diagnostics and Experimental Therapeutics, our multidisciplinary research group comprises basic researchers, gastroenterologists, surgeons, oncologists, and bioinformaticians, undertaking several collaborative projects involving large international consortia. This position has the potential to become tenure-track upon the receipt of grant funding lasting 3-5 years from a federal agency. Our research focuses on translational studies of the genomic and epigenomic characterization of various gastrointestinal cancers (GI), including colorectal, pancreatic, gastric, esophageal, and hepatocellular cancers. Our group performs cutting-edge research in GI oncology, is very productive, and publishes in high-impact journals such as Nature Cancer, Nature Communications, Nature Biotechnology, Nature Reviews Gastroenterology and Hepatology, New England Journal of Medicine, CA: A Journal for Clinicians, Gastroenterology, Cancer Cell, PNAS, JAMA Oncology, JNCI, Cancer Research, Clinical Cancer Research, , Annals of Surgery, etc. For more information on Dr. Goel's research, please visit here. If you are passionate about some of the following things, we are working on this may be the perfect opportunity: * Development of cell-free DNA (mutation and methylation), RNA, and exosomal-based liquid assays for early cancer detection, prognosis, and predictive responses to chemotherapies and targeted drugs. * Studying the genetic and epigenetic basis of GI cancers (e.g., aberrant DNA methylation, histone modifications, and non-coding RNAs). * Understanding the biological implications of gut microbiome and its translational application in gastrointestinal cancers * The genetic basis of early-onset colorectal cancer (EO-CRC) and familial/hereditary colorectal cancer. * The role of extracellular vesicles/exosomes in cancer pathogenesis and their role as disease biomarkers. * The role of the tumor microenvironment, stem cells, immune regulation, and identification of novel targeted therapies. * Cancer prevention and adjunctive role of natural and integrative therapy approaches. As a successful candidate, you will be: * Developing liquid biopsy biomarkers for cancer diagnosis, prognosis, and therapy response prediction. * Investigating the epigenetic basis of GI cancers, such as aberrant DNA methylation, histone modifications, and non-coding RNAs. * Exploring the genetics of early-onset and familial/hereditary colorectal cancers. * Studying the tumor microenvironment, stem cells, immune regulation, and identifying targeted therapies. * Investigating extracellular vesicles/exosomes in cancer pathogenesis and as disease biomarkers Your qualifications should include: * PhD, MD, or MD/PhD, with a strong background and profound knowledge in the field of oncology, cancer biology, immunology, or immunotherapy. * Prior molecular, cancer biology, and/or translational research experience and evidence of project development and supervision of post-doctoral fellows and technical staff. * Evidence of scientific rigor and excellence as documented by high-impact peer-reviewed publications, as a first/lead author. * Evidence for obtaining successful funding from various foundations or other extramural resources. * Documented evidence of mentoring post-docs, research associates, and others in a research laboratory environment. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the Pediatric Immunotherapy Research Lab (PI: Leo Wang) in the Beckman Research Institute of City of Hope, where we use cutting-edge techniques to understand and engineer potent immune responses against pediatric cancers. We are currently looking for a bright, ambitious, creative, and kind Staff Scientist with expertise and interest in fundamental immunology to join our group. We couple protein-focused molecular techniques with in vitro and in vivo disease models, as well as groundbreaking clinical trials, to understand how chimeric antigen receptors (CARs) signal and communicate with the endogenous immune system. We use this information to design solid-tumor targeted CAR effector cells with improved persistence and potency, as well as the ability to amplify the antitumor immune response. As a successful candidate, you will: * Design and lead projects focused on understanding and augmenting CAR T cell function in specific microenvironmental contexts, using canonical immune signaling and activation as a conceptual framework. * Coordinate lab tasks and operations among multiple lab members, including mentoring, training, and oversight; providing conceptual, technical, and experimental assistance; contributing to manuscripts and grant applications; and assembling reports and presentations. * Keep detailed and accurate logs of experimental design and primary data, analysis, and synthesis. * Prepare data presentations and manuscripts for publication. * Organize and maintain project workflow, both internally and in collaborations with other labs. Your qualifications should include: * The Staff Scientist must possess, at a minimum, a Ph.D. or other doctoral level degree, or equivalent professional experience. * Core competencies include cell and molecular biology, flow cytometry, protein biochemistry, and mouse work. * Extensive prior experience in immunology or a closely related field. Preferred qualifications: * Ph.D. or equivalent degree and 5 or more years of postdoctoral experience. Programming experience (R, Python). City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Research Associate II position is available in the laboratory of Adam de Smith. The lab's research in the Department of Pediatrics focuses on the etiology of childhood acute leukemia. We use molecular and epidemiological methodologies to advance our understanding of the germline genetic risk, somatic drivers, and early-life origins of childhood leukemia, with the ultimate goal of developing strategies for disease prevention. As a successful candidate, you will: * Perform a variety of routine and non-routine laboratory research experiments. Record and validate results for accuracy and completeness. * Troubleshoot procedures if experiment results are unexpected or unsatisfactory. Recommend alternative procedures. * Responsible for accurately recording work performed including results and methodology. Calculate, compile and analyze data obtained from work performed. * Independently evaluate research data and initiate alternative approaches to improve the quality of results by providing input to overall research design. Train lab staff in specialized procedures, equipment and theoretical concepts behind unique tests. * May contribute to the preparation of manuscripts by describing methods and specialized techniques. Keep abreast of new and improved techniques. * Ensure that all laboratory activities are carried out in compliance with each procedure(s) by utilizing safety procedures and guidelines in handling, storage and disposal of bio-hazardous, infectious and toxic material. Your qualifications should include: * Bachelor's degree in Biological Sciences or related field, with 2 years of post-degree research experience, or 1 year with a Master's degree * Hands-on experience with molecular genetics techniques, especially digital PCR, is preferred. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. City of Hope is seeking a detail-oriented Research Associate II to perform clinical trial activities and coordination, grant support, and preliminary image analysis in our Radiology department. Join us in advancing cancer research and improving patient outcomes through innovative imaging technologies. As a successful candidate, you will: * Coordinate radiology research studies and clinical trials focused on advancing imaging modalities for the diagnosis and treatment of disease. * Prepare, submit, and maintain regulatory (e.g., IRB) and budgetary documents for research studies and clinical trials. * Operate specialized equipment and software to support diverse research projects in collaboration with faculty, modality managers, and research leaders. * Maintain detailed records of work, including methodologies and results; validate data for accuracy and completeness; and compile findings into reports, graphs, and other documentation. * Ensure all research imaging activities comply with safety protocols and guidelines established by the FDA and the American College of Radiology. Your qualifications should include: * Bachelor's degree in Biomedical Engineering, Computer Science, or a related field with 2 years of post-degree research experience, or 1 year with a Master's degree. * 1-2 years of experience in imaging-related research or as an imaging technician in clinical or research environments is highly desirable. Preferred qualifications: * Preferred clinical research experience in oncology trials. * Experience in image analysis. * Experience with OnCore and IRB platforms. * Strong communication skills - Interfacing with CROs, faculty/physicians, and clinical trials office/sponsor projects office. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Research Associate II position is available within light microscopy and image analysis in the Light Microscopy and Digital Imaging Core facility working with the Director, Brian Armstrong, Ph.D. This position is for someone who enjoys working with people and helping scientists to achieve their imaging goals. You will be required to teach and assist others in the proper use of high quality computer operated microscope systems to include widefield, Confocal, and 2-photon microscope systems. As a successful candidate you will: * Train people on the use of high-end microscope systems. * Support imaging experiments from beginning to end including image analysis. Your qualifications should include: * Bachelor's degree. Masters degree preferred * 2+ years of related experience with a Bachelor's degree or 1+ year related experience with a Master's degree. * Interest in computers and analysis preferred. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Research Associate II position is available in the lab of Dr. Christine Brown of the T Cell Therapeutics Research Laboratories (TCTRL). This is a fast-paced lab involved in cutting-edge technology, research and clinical immunotherapeutic programs. We will train new personnel in project specific techniques and procedures. Work hours may vary. Please apply online for consideration. For more information about Dr. Brown's lab, please visit here. As a successful candidate, you will: * Perform tissue culture using aseptic techniques for media preparation, cell passaging, maintenance, and cryopreservation (e.g., T cell lines). * Conduct T cell functional assays such as cytotoxicity and cytokine production assays, as well as ELISAs. * Carry out cell staining for multicolor flow cytometry and analyze flow cytometry data. * Perform murine surgical procedures and prepare/harvest tissues. * Assist in revising and maintaining laboratory protocols. * Provide routine laboratory support and maintenance in alignment with Good Laboratory Practice (GLP) standards. Your qualifications should include: * Bachelor's degree. Master's degree preferred. * Two years related research/ laboratory experience with a Bachelor's degree or one year related research/ laboratory experience with a Master's degree. Preferred qualifications: * Hands-on experience with cellular immunology and standard good laboratory practices (GLP) desired. * Meticulous attention to detail and accuracy in lab work as well as accurate recordkeeping and lab documentation are a must. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. We are seeking a highly motivated and detail-oriented Research Associate II to join our dynamic team focused on cancer research. The successful candidate will contribute to studies investigating molecular mechanisms of ovarian tumor progression and therapeutic response using a variety of cell culture and molecular biology techniques. This position offers an excellent opportunity to gain hands-on research experience in a collaborative and fast-paced environment. As a successful candidate, you will: * Process cancer patient specimens (blood, urine, and saliva) for approximately three times a week. * Perform and maintain mammalian cell culture, including passaging, transfection, and cell-based assays. * Conduct molecular biology experiments such as DNA/RNA extraction, PCR, qPCR, ELISA, and Western blotting. * Participate in the design and execution of experiments, and analyze and interpret the results. * Maintain accurate and detailed experimental records. * Contribute to lab organization, reagent preparation, and inventory management. * Participate in regular team meetings and present data when appropriate. Your qualifications should include: * Bachelor's degree. Master's degree preferred. * Two years related research/ laboratory experience with a Bachelor's degree or one year related research/ laboratory experience with a Master's degree. Preferred qualifications: * Prior hands-on experience with cell culture and basic molecular biology techniques (academic or internship experience are preferred). * Strong attention to detail and excellent organizational skills. * Highly motivated, dependable, and eager to learn new techniques and concepts. * Desire and/or ability to work both independently and collaboratively as part of a research team. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. The Microbiome Program is seeking a highly motivated Research Associate I to support our expanding clinical research efforts. This role is essential to maintaining efficient lab operations and ensuring high-quality sample processing as patient enrollment increases. As a successful candidate, you will: * Process and aliquot human stool samples in accordance with established protocols. * Assemble stool collection kits for clinical study participants. * Perform routine laboratory maintenance, including inventory management, equipment cleaning, and supply restocking. * Maintain accurate records of sample handling and processing. * Assist with general lab workflows, including support for sample preparation and coordination. * Follow all safety, biosafety, and regulatory guidelines related to clinical research. Your qualifications should include * Bachelor's degree in biological sciences. * 0-2 years of research/laboratory experience. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. City of Hope is seeking a Research Associate II to join Dr. Elizabeth Budde's T Cell Therapeutics Research Laboratories. This role involves fast-paced research in cutting-edge technology, immunotherapeutic programs, and a commitment to delivering innovative solutions to critical illnesses. For more information on T Cell Therapeutics research, please visit here. As a successful candidate, you will be: * Conduct tissue culture, maintaining cell cultures and applying aseptic techniques for various cell lines, especially T cell lines. * Perform T cell functional assays, including cytotoxicity, cytokine production assays, and ELISAs. * Conduct cell staining for Multicolor Flow Cytometry and analyze flow cytometry data. * Assist in murine surgical procedures, tissue harvesting/preparation, and contribute to revising/maintaining lab protocols. * Provide routine lab support and maintain activities in accordance with Good Laboratory Practices (GLP). Your qualifications should include: * Bachelor's degree in Biological Sciences or related field, with 2 years of post-degree research experience, or 1 year with a Master's degree * Exceptional attention to detail, accuracy in lab work, and robust record-keeping skills * Preferred: Master's degree and hands-on experience in cellular immunology and GLP City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. City of Hope is seeking a Research Associate I to join Dr. Elizabeth Budde's T Cell Therapeutics Research Laboratories. This role involves fast-paced research in cutting-edge technology, immunotherapeutic programs, and a commitment to delivering innovative solutions to critical illnesses. For more information on T Cell Therapeutics research, please visit here. As a successful candidate, you will be: * Conduct tissue culture, maintaining cell cultures and applying aseptic techniques for various cell lines, especially T cell lines. * Perform T cell functional assays, including cytotoxicity, cytokine production assays, and ELISAs. * Conduct cell staining for Multicolor Flow Cytometry and analyze flow cytometry data. * Assist in murine surgical procedures, tissue harvesting/preparation, and contribute to revising/maintaining lab protocols. * Provide routine lab support and maintain activities in accordance with Good Laboratory Practices (GLP). Your qualifications should include: * Bachelor's Degree * Exceptional attention to detail, accuracy in lab work, and robust record-keeping skills City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions. Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Research Associate I position is available in the RSP Lab led by Dr. Sklavenitis Pistofidis. The RSP Lab (******************* leverages advanced multi-omic technologies, coupled with experimental perturbations and computational approaches, to decode tumor and immune biology and usher in a new era of biologically informed clinical care for patients with blood cancer, such as Multiple Myeloma. Our laboratory is part of the Judy & Bernard Briskin Center for Multiple Myeloma Research. We collaborate closely with clinicians who treat patients and run clinical trials at the City of Hope National Medical Center in Duarte, as well as other City of Hope centers in Orange County, Chicago, Phoenix, and Atlanta, reinforcing our translational focus and ensuring access to primary samples from a diverse, nation-wide pool of patients. Our high-throughput science is enabled by state-of-the-art facilities for next-generation sequencing and high-performance computing through the Translational Genomics Research Institute (TGen) at City of Hope. To accelerate the development of new therapies, we leverage City of Hope's unique in-house GMP manufacturing capabilities for cell therapy (CAR-T cells, stem cells, etc.), monoclonal antibodies, and small molecule generation, in line with our vested interest in commercializing our discoveries so that they can reach patients. As a successful candidate, you will: * Conduct laboratory-based and computational research projects focusing on multiple myeloma and lymphoma. * Have the opportunity to develop skills in experimental and computational biology to study blood cancer and the immune system and develop new therapies. * Apply advanced single-cell multi-omic and genomic engineering technologies on patient samples or cell lines and analyze high-dimensional datasets to identify new biomarkers of response & resistance to therapy and develop new therapeutic targets. * Develop your skills in scientific writing and application writing, as well as lab and resource management and record-keeping. Your qualifications should include: * Bachelor's degree with 0-2 years of research/laboratory experience in molecular/cellular biology and/or computational biology. * Excellent oral and written communication skills. * Ability to meet deadlines, manage their time, and multi-task. * Ability to collaborate and work within multi-disciplinary teams of people with varied levels of experience. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Research Associate II position is available in the Dhawan Lab at the Arthur Riggs Diabetes and Metabolism Research Institute. You will perform standard laboratory molecular, cell biology, and bioinformatics techniques, towards understanding mechanisms that regulate pancreatic beta-cell development, function, and regeneration, as well as diabetes pathogenesis. You should have good organizational skills, experience in performing routine laboratory methods, and a mindset to learn new scientific skills. As a successful candidate, you will: * Perform a variety of routine and non-routine experiments utilizing a broad spectrum of molecular and cellular biology techniques to include but not limited to: mammalian cell culture including primary cultures and stable cell lines, iPSCs, DNA and RNA isolation, RNA and spatial sample preparation, sequencing library preparation, RT-PCRs, Western blot, immunohistochemistry, tissue collection and processing, islet physiology in vivo and in vitro, mouse genetics, confocal imaging and image analysis. * Develop and optimize new laboratory methods and help refine existing methods, troubleshoot experimental procedures if experiment outcomes are unexpected or unsatisfactory. * Accurately record experimental plans and work performed including results and methodology as well as analyze and compile data obtained. * Lead the management of laboratory inventories, prepare stock solutions, handle and dispose biohazardous and non-biohazardous materials according to safety protocols when necessary. * Train lab staff in specialized procedures, equipment and theoretical concepts behind unique tests. * Contribute to the preparation of manuscripts and presentations. Your qualifications should include: * Bachelor's degree in Biological Sciences or related field, with 2 years of post-degree research experience, or 1 year with a Master's degree * Experience in an academic or industrial laboratory setting is preferred. * Familiarity with routine molecular and cellular biological techniques, such as DNA and RNA isolation, qRT-PCR, Western blot, cell culture, and other related techniques. * Experience in tissue isolation, operation of a microtome and cryostat and histological analysis, is preferred. * Proficiency in MS Office applications, R Package or Python. * Flexible and available to work on weekends when required to meet project deadlines or team needs. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. City of Hope is seeking a Research Associate II to join the T Cell Therapeutics Research Laboratory. This role involves fast-paced research in cutting-edge technology, immunotherapeutic programs, and a commitment to delivering innovative solutions to critical illnesses. For more information on Dr. Lior Goldberg's research, please visit here. As a successful candidate, you will be: * Conduct tissue culture, maintaining cell cultures and applying aseptic techniques for various cell lines, especially T cell lines. * Perform T cell functional assays, including cytotoxicity, cytokine production assays, and ELISAs. * Conduct cell staining for Multicolor Flow Cytometry and analyze flow cytometry data. * Assist in murine surgical procedures, tissue harvesting/preparation, and contribute to revising/maintaining lab protocols. * Provide routine lab support and maintain activities in accordance with Good Laboratory Practices (GLP). Your qualifications should include: * Bachelor's degree in Biological Sciences or related field, with 2 years of post-degree research experience, or 1 year with a Master's degree * Exceptional attention to detail, accuracy in lab work, and robust record-keeping skills * Must be flexible as work hours may vary * Preferred: Master's degree and hands-on experience in cellular immunology and GLP City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at City of Hope where our mission is to transform the future of cancer care through precision medicine and innovative immuno-oncology. We are seeking a highly motivated and hands-on Research Associate II to support laboratory-based research on colorectal cancer immunotherapy and tumor microenvironment biology. This position is ideal for a candidate eager to gain advanced experience in spatial and single-cell technologies, clinical translational research, and biomarker discovery. The successful candidate will work closely with Dr. Marwan Fakih and Dr. Jian Ye, contributing directly to ongoing clinical-correlative studies and mechanistic projects using cutting-edge techniques. You will be part of a translational research team tackling immunotherapy resistance in colorectal cancer, using state-of-the-art spatial and molecular platforms. This position provides an exceptional opportunity to develop hands-on skills in both clinical sample handling and cutting-edge research technologies, with publication opportunities. As a successful candidate, you will: * Perform wet-lab and technical experimental work related to translational immuno-oncology studies in colorectal cancer. * Process and manage clinical biospecimens (tumor tissues, blood, and FFPE samples) for downstream molecular and spatial analyses. * Conduct advanced spatial biology and immunology assays. * Maintain organized sample inventory, records, and reagent tracking. * Assist with basic data analysis, figure preparation, and presentation of results. * Collaborate with clinicians and scientists to integrate molecular and imaging data for mechanistic and biomarker discovery studies. * Contribute to the preparation of research reports, manuscripts, and grant applications. Your qualifications should include: * Bachelor's degree in Biology, Molecular Biology, Immunology ore related field. Master's degree preferred. * Two years related research/ laboratory experience with a Bachelor's degree or one year related research/ laboratory experience with a Master's degree. Preferred qualifications: * Prior experience with immunohistochemistry, flow cytometry, or molecular biology techniques is strongly preferred. * Experience with spatial transcriptomics, multiplex imaging, or single-cell technologies is a plus but not required. * Strong motivation to learn and contribute to both clinical and basic cancer research. * Ideal for candidates interested in pursuing future graduate, medical, or academic research careers. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. A Research Associate II position is available in the laboratory of Leo D. Wang, MD, PhD, at City of Hope, Duarte, CA. The lab's research in the Department of Immuno-Oncology focuses on how blood and immune cells develop, function, and interact with other cells, with a second focus on how blood stem cells become malignant. We use mass spectrometry to identify activated protein circuits in rare blood stem and progenitor cell populations, including therapeutic chimeric antigen receptor (CAR) T cells, and use that knowledge to improve and devise new therapies for pediatric cancers and blood disorders. As a successful candidate, you will: * Coordinate lab tasks and operations, including ordering, inventory, and other essential functions. * Prepare laboratory reagents, chemicals, instruments, and maintain equipment. * Perform a variety of routine and non-routine laboratory research experiments. Record and validate results and methodology for accuracy and completeness. * Perform preclinical rodent work (mouse handling, screening, injections, and analysis). Troubleshoot procedures if experiment results are unexpected or unsatisfactory. Recommend alternative procedures. * Calculate, compile and analyze data obtained from work performed. * Independently evaluate research data and initiate alternative approaches to improve the quality of results by providing input to overall research design. Train lab staff in specialized procedures, equipment and theoretical concepts behind unique tests. * Keep detailed and accurate logs of experiments from conception to analysis, as well as of lab inventory and animal colonies. * May contribute to the preparation of manuscripts by describing methods and specialized techniques. * There may be some travel to local area research labs for collaborations, trainings, & operational expansion. Your qualifications should include: * Bachelor's degree. Master's degree preferred. * Two years related research/ laboratory experience with a Bachelor's degree or one year related research/ laboratory experience with a Master's degree. Preferred qualifications: * Hands-on experience with flow cytometry, molecular biology, and cell culture is preferred. * Computational skills (R, Python) are beneficial. * Experience with animal husbandry also a plus. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the transformative team at City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. City of Hope's growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and treatment facilities in Atlanta, Chicago and Phoenix. our dedicated and compassionate employees are driven by a common mission: To deliver the cures of tomorrow to the people who need them today. We seek a Research Associate candidate within the multidisciplinary research team headed by Dr. Ajay Goel, Professor and Chair Department of Molecular Diagnostics and Experimental Therapeutics and Associate Director of Basic Sciences, City of Hope Comprehensive Cancer. Our research is focused on translational research on the genomic and epigenomic characterization of various gastrointestinal cancers (GI), including colorectal, pancreatic, and gastric cancers. Some of the key research topics in our laboratory include: * Developing ct DNA and cf RNA-based liquid biopsy biomarkers for cancer diagnosis, prognosis, and predictive responses to various therapies. * Study the epigenetic basis of GI cancers (e.g., aberrant DNA methylation, histone modifications, and non-coding RNAs). * The genetic basis of early-onset and familial/hereditary colorectal cancers. * The role of the tumor microenvironment, stem cells, immune regulation, and identification of novel targeted therapies. * The role of extracellular vesicles/exosomes in cancer pathogenesis and their role as disease biomarkers. As a successful candidate, you will: * Maintain various aspects of lab management, including maintenance and upkeep of reagent and clinical specimen inventories, ordering, lab safety, and regulatory tasks. * Ensure that all laboratory activities comply with each procedure(s) by utilizing safety procedures and guidelines in handling, storage, and disposal of bio-hazardous, infectious, and toxic material. * Perform a variety of routine and non-routine laboratory research experiments nd record and validate results for accuracy and completeness. * Perform Cancer Genetics and Epigenetics techniques and general lab maintenance that assists in conducting an Investigator's Research Project. * Be responsible for accurately recording work performed, including results and methodology. Your qualifications should include: * Bachelor's or master's degree; master's degree preferred. * Two years of laboratory experience with a bachelor's degree or 3 years of related research/ laboratory experience with a master's degree * Assist and perform various molecular biology techniques, such as tissue culture, flow cytometry (analysis), and molecular tests, according to the Laboratory's Standard Operating Procedures. City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity, and inclusion, please click here. To learn more about our Comprehensive Benefits, please CLICK HERE.

Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions. * For consideration, please email your resume to Dr. Jianjun Chen at **************** * Pay Rate: $33.00-$42.07 per hour Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. Dr. Jianjun Chen's lab in the Systems Biology Department in the Beckman Research Institute at the City of Hope is in search of a Research Associate II (RA II). Dr. Chen's lab is interested in RNA/DNA cancer epigenetics studies (focusing on both basic and translational research). The ultimate goal of the laboratory is to translate the laboratory discoveries into the development and application of effective novel therapeutic strategies to treat cancers in the clinic. For more information about Dr. Chen's lab, please visit here. As a successful candidate, you will: * Assist with laboratory research by providing technical support, preparing, and arranging reagents, managing mouse colonies, and overseeing stock ordering and inventory. * Perform mouse handling, including husbandry, injections including drug-treatments, proficiency in collection of submandibular blood of mice. * Conduct bulk plasmid purification, PCR, gel electrophoresis, genotyping, Western blotting. * Maintain adherent and suspension cell cultures. * Test out new reagents/products for potential lab use. * Additional consideration for applicants with previous clearance for animal irradiation and/or previous experience in flow cytometry for quantification of xenograft engraftment. Your qualifications should include: * Bachelor's degree. Master's degree preferred. * Two years related research/ laboratory experience with a Bachelor's degree or one year related research/ laboratory experience with a Master's degree. Preferred qualifications: * Meticulous record keeping, impeccable organization and proficiency with databases. * Exceptional managerial and organizational skills. * Excellent written and verbal communication. * Strong work ethic, highly motivated, and work well independently and in a team. * Experience with genetic mouse models, RNA biology, tissue culture, cellular and molecular biology techniques is a big plus. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. Led by Dr. Ajay Goel, Professor and Founding Chair of the Department of Molecular Diagnostics and Experimental Therapeutics, our multidisciplinary research group comprises basic researchers, gastroenterologists, surgeons, oncologists, and bioinformaticians, undertaking several collaborative projects involving large international consortia. This position has the potential to become tenure-track upon the receipt of grant funding lasting 3-5 years from a federal agency. Our research focuses on translational studies of the genomic and epigenomic characterization of various gastrointestinal cancers (GI), including colorectal, pancreatic, gastric, esophageal, and hepatocellular cancers. Our group performs cutting-edge research in GI oncology, is very productive, and publishes in high-impact journals such as Nature Cancer, Nature Communications, Nature Biotechnology, Nature Reviews Gastroenterology and Hepatology, New England Journal of Medicine, CA: A Journal for Clinicians, Gastroenterology, Cancer Cell, PNAS, JAMA Oncology, JNCI, Cancer Research, Clinical Cancer Research, , Annals of Surgery, etc. For more information on Dr. Goel's research, please visit here. As a successful candidate, you will: * Conduct routine and non-routine experiments, recording and validating results. * Troubleshoot and recommend alternative procedures for unsatisfactory results. * Accurately record work, calculate, compile, and analyze data. * Evaluate research data and suggest improvements, train staff in specialized procedures and concepts. * Assist in manuscript preparation by detailing methods and techniques; stay updated on new techniques. * Ensure compliance with safety procedures for handling hazardous materials. Your qualifications should include: * Bachelor's degree in Biological Sciences or related field, with 2 years of post-degree research experience, or 1 year with a Master's degree * Exceptional attention to detail, accuracy in lab work, and robust record-keeping skills City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. Led by Dr. Ajay Goel, Professor and Founding Chair of the Department of Molecular Diagnostics and Experimental Therapeutics, our multidisciplinary research group comprises basic researchers, gastroenterologists, surgeons, oncologists, and bioinformaticians, undertaking several collaborative projects involving large international consortia. This position has the potential to become tenure-track upon the receipt of grant funding lasting 3-5 years from a federal agency. Our research focuses on translational studies of the genomic and epigenomic characterization of various gastrointestinal cancers (GI), including colorectal, pancreatic, gastric, esophageal, and hepatocellular cancers. Our group performs cutting-edge research in GI oncology, is very productive, and publishes in high-impact journals such as Nature Cancer, Nature Communications, Nature Biotechnology, Nature Reviews Gastroenterology and Hepatology, New England Journal of Medicine, CA: A Journal for Clinicians, Gastroenterology, Cancer Cell, PNAS, JAMA Oncology, JNCI, Cancer Research, Clinical Cancer Research, , Annals of Surgery, etc. For more information on Dr. Goel's research, please visit here. If you are passionate about some of the following things we are working on this may be the perfect opportunity: * Development of cell-free DNA (mutation and methylation), RNA, and exosomal-based liquid assays for early cancer detection, prognosis, and predictive responses to chemotherapies and targeted drugs. * Studying the genetic and epigenetic basis of GI cancers (e.g., aberrant DNA methylation, histone modifications, and non-coding RNAs). * Understanding the biological implications of gut microbiome and its translational application is gastrointestinal cancers * The genetic basis of early-onset colorectal cancer (EO-CRC) and familial/hereditary colorectal cancer. * The role of extracellular vesicles/exosomes in cancer pathogenesis and their role as disease biomarkers. * The role of the tumor microenvironment, stem cells, immune regulation, and identification of novel targeted therapies. * Cancer prevention and adjunctive role of natural and integrative therapy approaches. As a successful candidate, you will: * Devise, plan, document, and advance basic science and translational projects in genetics, epigenetics, and precision oncology of gastrointestinal cancers. * Generate data for grant applications and prepare manuscripts for publication. * Work closely with other team members and external collaborators, including presenting progress internally or externally. * Ability to work in a fast-paced team environment and handle multiple projects simultaneously. Your qualifications should include: * Ph.D., MD, or MD/Ph.D., with a strong background and profound knowledge in oncology, cancer biology, immunology, or immunotherapy. * Ability to work in a fast-paced research environment and manage multiple projects and collaborations. * Previous experience working with human specimens and developing novel, innovative cancer biomarkers. * Evidence of scientific rigor and excellence as documented by high-impact peer-reviewed publications. * Strong team player with excellent communication skills and fluency in spoken and written English. * A strong track record of relevant original, peer reviewed publications, as a first author. * The individual must have effective skills in oral and written communication, teamwork, and problem-solving and be adaptable to changes in technological and scientific directions. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. City of Hope is an equal opportunity employer. To learn more about our Comprehensive Benefits, please CLICK HERE.