Crinetics Pharmaceuticals jobs in San Diego, CA

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Director of Corporate Strategy & Analytics will lead strategic initiatives that define Crinetics' long-term growth trajectory. This role combines corporate strategy, new product planning, market insights & analytics, and ensures strategic alignment across research, development, and commercialization. The position requires strong analytical capabilities, deep industry knowledge, and proven leadership skills to influence decisions at the highest levels. Developing and maintaining a deep and responsive bench of creative analysts able to integrate both technical and business considerations in support of strategy development will be a key enabling responsibility of this role. Essential Job Functions and Responsibilities: These may include but are not limited to: Strategic Leadership & Analytics Partner with New Product Planning, Portfolio Strategy, and R&D to enhance Crinetics story. Influence program teams in proposing and refining business strategies for intended markets and provide a business lens to enable key project decisions around Crinetics pipeline. Take ownership of various types of strategic analyses delegated by executive leadership, then lead and drive decision-making throughout the workstream, leveraging internal resources as determined necessary. Develop and oversee complex valuation models (DCF, comparables, scenario analyses) for portfolio decisions and ex-US expansion opportunities. Work closely with Portfolio Strategy team to identify and refine key internal and external business opportunities, developing appropriate analytical frameworks to support assessments Collaborate with Business Development on overall partnering strategy and support Search & Evaluation efforts Partner with Investor Relations to support messaging w/key external stakeholders Market Intelligence Maintain awareness of healthcare and pharmaceutical industry trends and assess their impact on corporate strategy Coordinate and synthesize market insights, analytics, and competitive intelligence to identify opportunities and inform portfolio decisions Act as a strategic advisor to Discovery therapeutic area leads and Global Product Leads, informing on market opportunities for early R&D programs Team Leadership & Development Hire, mentor, and develop a high-performing analytics team, including a direct report and staff (3 people total) Contribute to budget and headcount planning for the Corporate Development group Foster a culture of accountability, collaboration, and continuous improvement Communication & Executive Engagement Synthesize key insights and conclusions from cross functional working teams and present recommendations to Executive Leadership Team for consideration, evaluation, and decision-making Partner with R&D, Legal, Finance, and Medical teams to integrate business considerations into program strategies Education and Experience: Required: BA/BS required; MBA or graduate degree in relevant scientific discipline PhD/MD/PharmD strongly preferred Minimum of 12 years pharmaceutical or post-graduate experience; candidates with consulting or industry or highly relevant post-doctoral work will be considered (an equivalent combination of experience and education may be considered) Minimum of 8 years of leadership/supervisory experience. Strong analytical skillset; significant forecast modeling experience, critical analysis of clinical/financial datasets Strong communication and organizational skills, business and scientific acumen Advanced understanding of CI processes, methods, industry ethics and compliance, is required Ability to collaboratively work in a small company environment and contribute to many different functions Preferred: Knowledge of endocrine/endocrine oncology field a plus Strong understanding of the biopharmaceutical R&D and commercialization process, as well as knowledge of the industry landscape (e.g., companies, transactions, terms) preferred Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 5% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Salary Range The salary range for this position is: $188,000 - $235,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Executive Director, Corporate Legal Counsel page is loaded## Executive Director, Corporate Legal Counselremote type: Hybrid-San Diegolocations: San Diego, CAtime type: Full timeposted on: Posted Todayjob requisition id: JR000519**Salary Range**The salary range for this position is: $281,000 - $351,000.*In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.* #J-18808-Ljbffr

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: We are seeking a highly motivated and collaborative Principal Scientist with experience in GPCR pharmacology and drug discovery to join our growing and dynamic in vitro pharmacology team. A successful candidate will be responsible for providing in vitro pharmacology leadership for lead optimization campaigns, mechanism of action studies, and new target efforts in endocrinology. Essential Job Functions and Responsibilities: These may include but are not limited to: Lead and manage a small team of junior scientists, promoting collaboration, efficiency, and innovative science. Design, develop, validate, and execute in vitro assays that support drug discovery programs. Conduct critical analysis and interpret data into meaningful understanding of small molecule ligand activity and mechanism of action. Demonstrate high level of initiative to oversee, troubleshoot, and accurately perform data analysis in an environment that values scientific integrity and quality. Conduct resource management to deliver critical in vitro pharmacology data to support multiple programs simultaneously. Lead and/or provide in vitro pharmacology leadership role on cross-functional program teams. Interpret and demonstrate effective written and oral communication of results to interdisciplinary teams. Participate in the strategic planning of departmental growth and organization. Lead external collaborations and outsourced studies. Identify and evaluate new research targets within therapeutic areas of interest. Author scientific publications and prepare technical reports to support regulatory submissions. Ensure compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards. Other duties as assigned. Education and Experience: Required: Ph.D. in Pharmacology, Biochemistry, Biology, or related discipline with a minimum of 8 years of relevant experience. Applicants with BS or MS degrees must demonstrate a minimum of 18 years of significant and relevant experience. At least 7 years of experience with drug discovery and small molecule pharmacology at therapeutically relevant GPCRs or related field. Demonstrated technical proficiency in biochemical, cellular, and/or radioligand binding assay systems and ability to ensure highest quality of in vitro assay data. Ability to independently determine in vitro pharmacologic methods and procedures to achieve Program goals. Outstanding experimental design, problem-solving, and data analysis skills and the ability to independently establish in vitro pharmacologic approaches to achieve program goals. Demonstrated practical experience and deep understanding of in vitro pharmacological theory, models, mechanisms, and experimental design, particularly with GPCRs Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature. Strong work ethic and enthusiasm for a mix of laboratory work and management in a dynamic environment. Experience in management and daily supervision of scientific staff is highly preferred. Experience in program management/leadership desired. Strong written and verbal communication skills and ability to work effectively in a multidisciplinary team environment. Experience with writing reports and technical regulatory documents Must be detail-oriented, punctual, and reliable. Ability to work in a fast-paced environment and adapt to change. Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 5% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Salary Range The salary range for this position is: $158,000 - $197,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Environmental Health & Safety (EH&S) Specialist is responsible for supporting compliance with all applicable environmental, health, and safety regulations. This role involves promoting adherence to EHS programs, conducting risk assessments, assisting with incident investigations, and role-modeling a culture of safety and environmental stewardship. The EH&S Specialist collaborates with cross-functional teams to help ensure safe operations and maintain regulatory compliance. Essential Job Functions and Responsibilities: These may include but are not limited to: Ensure compliance with local, state, and federal regulations (e.g., OSHA, Cal/OSHA, EPA, DOT). Assist in delivering EHS training programs for employees and contractors. Support EHS-related committees such as the Safety Committee, Emergency Response Team, First Responders, and Spill Response Team. Conduct risk assessments and assist in implementing mitigation strategies for job-related hazards. Respond to and assist in investigating incidents, including injuries, chemical/biological spills, and near-misses. Document incident reports and maintain tracking systems to ensure timely follow-up and resolution. Conduct internal EHS inspections and support third-party audits. Assist with external audits and inspections, ensuring corrective actions are documented. Ensure hazardous waste and materials transportation complies with applicable laws. Assist with updating Safety Data Sheets (SDS) and chemical inventory. Collaborate with Facilities to support emergency events and site-specific emergency action plans. Maintain accurate EHS records and assist in preparing reports for internal and external stakeholders. Promote safe work practices through ergonomic assessments and safety awareness campaigns. Perform additional tasks as needed to support health and safety, environmental protection, and business continuity. Uphold the company's reputation through regulatory compliance, ethical conduct, and proactive risk awareness. Education and Experience: Required: Bachelor's degree in Environmental Science, Occupational Health, Safety Management, or related field. 2+ years of experience in EH&S roles, in biotech or laboratory environments. Strong knowledge of OSHA, EPA, DOT, and Cal/OSHA regulations. Experience conducting risk assessments, audits, and incident investigations. Excellent communication and organizational skills. Experience with hazardous waste management and emergency response planning. Proficiency in EH&S reporting systems and excellent PC-based computer skills including Windows and MS Office. Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 5% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Salary Range The salary range for this position is: $79,000 - $99,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: Crinetics is seeking a highly experienced and strategic Director, Privacy Legal Counsel to lead and oversee the company's global privacy program. Reporting to the Chief Legal Officer, this role is critical in ensuring compliance with United States and international privacy regulations, standards, and industry best practices. The Director will be Crinetics' privacy subject-matter expert, advising on privacy, data protection, cybersecurity, and data governance initiatives across R&D, clinical development, IT, HR, and commercial operations. The ideal candidate will bring deep experience counseling life-sciences organizations, a sophisticated understanding of global privacy frameworks, and the ability to translate complex legal requirements into actionable business guidance that supports innovation, patient trust, and ethical data use. Essential Job Functions and Responsibilities: These may include but are not limited to: Lead, design, implement, and maintain a comprehensive global privacy and data protection program, including policies, standards, procedures, and controls that align with U.S. and international regulations and industry best practices. Serve as the company's primary advisor and subject-matter expert on privacy, data protection, cybersecurity, and data-use ethics across all business functions, including clinical development, research, pharmacovigilance, HR, IT, and commercial operations. Provide practical, timely, and strategic legal advice on privacy and data-security issues impacting research, development, and commercialization activities, balancing risk mitigation with operational efficiency. Counsel on privacy and data-protection considerations throughout the clinical-trial lifecycle, including informed consent, pseudonymization and de-identification, secondary data use, and cross-border data transfers involving CROs, investigators, vendors, and regulators. Support compliant data-use practices for real-world evidence, pharmacovigilance, patient-support programs, and digital health platforms, ensuring lawful processing and appropriate safeguards for sensitive health information. Advise on privacy, data-governance, and ethical considerations in connection with artificial intelligence (AI), machine learning (ML), and emerging digital technologies, including transparency, fairness, and explainability requirements under evolving AI and data-use frameworks (e.g., EU AI Act, Colorado AI Act). Monitor, interpret, and implement strategies to comply with emerging privacy and AI laws, including the GDPR, HIPAA, CCPA/CPRA, Colorado Privacy Act, Virginia Consumer Data Protection Act, Washington My Health My Data Act, Oregon Consumer Privacy Act, and other state, federal, and global regulations. Oversee Privacy Impact Assessments (PIAs) and Data Protection Impact Assessments (DPIAs) for systems, clinical programs, and data-processing activities, and advise on remediation and risk-mitigation measures. Draft, review, and negotiate data-protection and privacy provisions in vendor, commercial, collaboration, and clinical research agreements, ensuring alignment with company policies and global legal requirements. Provide legal support for cross-border data transfers, including evaluation and implementation of Standard Contractual Clauses (SCCs), Transfer Impact Assessments (TIAs), and other transfer mechanisms. Partner with Compliance, IT, and Information Security to establish governance frameworks for data classification, access, retention, and disposal, promoting “privacy by design” and “security by default.” Play a leadership role in incident response investigations involving potential privacy or data-security events, including assessing regulatory notification obligations and advising on root-cause and remediation efforts. Develop and deliver enterprise-wide privacy training and communications to strengthen understanding of data-protection principles, regulatory requirements, and ethical data handling across the organization. Build strong cross-functional relationships with R&D, clinical, IT, HR, Compliance, and Commercial teams to foster a proactive, collaborative, and accountable privacy culture. Other duties as assigned Education and Experience: Required: Juris Doctor degree from accredited law school required 10+ years of relevant experience, with at least 5+ years in the biotechnology, pharmaceutical, or healthcare industry focusing on privacy and data protection. Leadership: a minimum of 8 years of experience as a supervisor with strong leadership skills and experience managing and developing high-performing teams. Ability to influence senior executives and cross-functional teams. Deep knowledge of HIPAA, GDPR, U.S. federal and state privacy laws, and global data-transfer frameworks. Proven experience developing and operationalizing privacy programs and managing complex, cross-functional privacy issues. Strong contract drafting and negotiation skills related to research agreements, particularly vendor, data-processing, and clinical agreements. In addition to top-notch legal skills and a strong ethical center, excellent interpersonal, strategic thinking, communication and organizational skills Ability to build consensus with diverse stakeholders and form strong, collaborative working relationships Ability to handle multiple projects in a fast-paced environment and exercise sound legal judgment In-house experience with product counseling, compliance, litigation, and regulatory teams Experience with commercial or consumer contracts involving data privacy High level of business acumen, excellent contract drafting and negotiation proficiency Preferred: CIPP/US, CIPM, or equivalent privacy certification. AIGP or similar AI governance credentials. Experience supporting AI-driven innovation. Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 10% of your time, approximately once per quarter. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Salary Range The salary range for this position is: $170,000 - $213,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: We are seeking a highly skilled and strategic Senior Microsoft Engineer to play a pivotal role in shaping and managing our core Microsoft and Azure platforms. This role is critical for providing senior-level engineering expertise needed to manage Crinetics' expanding and complex Microsoft online and Azure environment. The ideal candidate will be a subject matter expert in Microsoft's cloud ecosystem, responsible for designing, implementing, and managing robust, scalable, and secure solutions. This role requires a deep understanding of Azure infrastructure, extensive experience in modern DevOps practices, and a proven track record in utilizing advanced AI and security services. Essential Job Functions and Responsibilities: These may include, but are not limited to: Lead the design and implementation of enterprise-level solutions on Microsoft Azure and M365 platforms. Develop/maintain the SharePoint environment and integrations. Deploy, and manage core Azure services, including networking, computers, storage, and security. Oversee the administration and optimization of Microsoft 365 online services, with a focus on integrating and deploying solutions using Microsoft Copilot to enhance productivity and workflows. Experience with Copilot studio. Manage and optimize SharePoint environments, delivering solutions, migrations, and integrations with Microsoft 365. Utilize Microsoft Intune for mobile device management (MDM) and mobile application management (MAM). Implement and manage continuous integration and continuous delivery (CI/CD) pipelines using Azure DevOps or GitHub. : Develop and maintain IaC scripts and templates using tools like Bicep and Terraform to automate infrastructure deployment and management. : Partner with IT Security to ensure all solutions meet security best practices and compliance requirements. Possess strong stakeholder management Possess excellent communication and presentation skills to collaborate across technical and business teams Provide technical guidance to other team members. Education and Experience: Required: Bachelor's degree in Computer Science, Information Technology, or a related field, 8+ years IT experience, with 5+ years focused on Azure. Proven experience as a senior-level Azure Engineer, Solutions Architect, or similar role. Extensive experience with Microsoft 365 online services, including administration, security, and compliance. Experience with Microsoft Purview for discovery, data classification, and related securities. In-depth knowledge of Azure infrastructure, including networking, virtual machines, and storage. Strong experience with Azure integrations and App Services. Solid background in DevOps, CI/CD, and modern development methodologies. Hands-on experience with Infrastructure as Code using Bicep and/or Terraform. Designing, configuring, and using IaaS services (like VM, Azure Kubernetes Services, networking, storage) Working in Azure DevOps Troubleshooting complex scenarios related to Application Deployment Project Management experience; Understanding and practical experience of Agile. Strong written and verbal communication skills. Preferred: Microsoft Certified: Azure Solutions Architect Expert or other relevant certifications. Experience with enterprise governance and cost management in Azure. Familiarity with other cloud platforms (GCP, AWS) Industry Experience: Experience in the pharmaceutical industry is highly desirable. Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 5% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Salary Range The salary range for this position is: $134,000 - $167,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Senior Process Chemist 2, Drug Substance Development, will be responsible for designing, optimizing, and scaling synthetic chemical processes for active pharmaceutical ingredients (APIs). This role will work closely with cross-functional teams to ensure that new processes are efficient, cost-effective, safe, and compliant with regulatory standards for large-scale manufacturing. This position will report to the Director, Drug Substance Development CMC. The Technical Operations team is highly collaborative and operates with a global network of highly qualified Contract-Research Organizations (CROs) and Contract Development and Manufacturing Organizations (CDMOs). This position will be an integral part of the company's effort to discover and develop small molecule therapeutics for rare endocrine disorders. This is a unique opportunity to work with a proven and well-funded drug discovery and development company in the heart of San Diego's biotechnology community. This position will be located in San Diego. Essential Job Functions and Responsibilities: These may include but are not limited to: Develop and optimize synthetic routes for APIs from lab to pilot-plant scale. Collaborate with analytical chemistry and formulation teams to characterize intermediates and final products. Conduct risk assessments to ensure safety and environmental compliance. Generate process documentation, including batch records, SOPs, and technical reports. Explain complex scientific and technical concepts, influencing others to adopt new points of view. Manage daily activities of a small functional group, identifying ways to improve efficiencies and best practices within the work unit. Contribute to key reviewed scientific/technical documents, expert reports, or patents that enhance the company's intellectual capital. Evaluate scalability and robustness of chemical processes using Design of Experiments (DoE). Lead technology transfer of processes to manufacturing and contract development organizations (CDMOs). Troubleshoot process issues and implement improvements for cost, yield, and quality. Stay up-to-date on regulatory requirements, including cGMP and ICH guidelines. Support regulatory filings (INDs, IMPDs, NDAs, briefing packages, and other regulatory dossier) as needed. Other duties as assigned. Education and Experience: Required: Ph.D. in organic chemistry or related field, with a minimum of 5-8 years of relevant hands-on experience in pharmaceutical, biotech laboratory, or CDMOs. (Masters with 13 years of experience or Bachelors with 15 years of experience may be considered). Strong background in organic synthesis, reaction mechanisms, and crystallization techniques. Extensive expertise in conducting chemical reactions as a process chemist, with a solid understanding of laboratory design to facilitate commercial route development. Familiarity with scale-up principles and pilot-plant operations. Knowledge of process analytical technology (PAT) and Quality by Design (QbD). Proficient in scientific software (e.g., ChemDraw, MATLAB, or similar). Significant and direct work experience with instruments used in laboratories in analytical techniques such as HPLC/UPLC, and solid-state characterization tools, including DSC, TGA, DVS, XRPD, microscopy, etc. Knowledge of cGMP requirements and regulatory guidance (FDA, ICH). Excellent written and oral communication skills, including drafting and reviewing technical documents, and the ability to effectively and accurately present data to peers, management, and external partners. Excellent ability to work in a goal and team-oriented setting and handle competing priorities. Flexibility within a rapidly changing environment and high attention to detail. Well-developed organizational skills and the ability to thrive under pressure. Intermediate to advanced software skills (e.g., Microsoft Excel, PowerPoint, MS Project). Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at a desk for a long period of time; intermittently answer the telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Travel: You may be required to travel for up to 10% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Salary Range The salary range for this position is: $134,000 - $167,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Associate Scientist, In Vivo Pharmacology will work collaboratively and be responsible for performing a variety of pre-clinical in vivo experiments. The work will support projects at various stages of development thereby allowing the selected candidate to play an active role in our drug discovery and development efforts to advance small molecule therapeutics for endocrine disorders and endocrine-related cancers. Essential Job Functions and Responsibilities: These may include but are not limited to: Design and conduct pre-clinical in vivo experiments to evaluate the pharmacodynamics, pharmacokinetics, and safety of therapeutic candidate molecules. Develop new animal models for evaluating novel small molecules for endocrine diseases Demonstrate a high level of initiative to troubleshoot and accurately perform in vivo studies. Ensure that the care and welfare of laboratory animals is in accordance with regulations and IACUC protocols. Generate and manage purchase orders, contracts, and other related documents. Present findings at team and departmental meetings. Perform animal husbandry to conduct biological assays. Run and troubleshoot biomarker assays e.g. ELISAs, LUMINEX assays. Analysis of experimental data using MS Office, PRISM or comparable software Comply with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards. Other duties as assigned Education and Experience: Bachelor's in Biology, Pharmacology, Neuroscience, Toxicology or related discipline with a minimum of 8 years of significant and relevant experience or alternatively Master's degree with a minimum of 6 years of significant and relevant experience. Proven hands-on proficiency in rodent (rats and mice) handling procedures and in vivo skills including dosing (IV, PO, SC) blood and tissue collection, necropsy, etc.Experience in designing and conducting rodent in vivo pharmacology studies Experience with ELISA and biomarker assays Proficient in basic surgical techniques in rodents. Must be independent and able to follow pre-established experimental designs, as well as develop new methods and protocols or technologies as needed. Strong communication skills and ability to effectively communicate and present summaries of research results to team members Strong organizational skills with great attention to details and ability to troubleshoot problems. Strong work ethic, ability to multi-task and be enthusiastic for animal and laboratory work. Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology, chemical laboratory and vivarium environments experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 5% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws Salary Range The salary range for this position is: $107,000 - $134,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Senior Director, Clinical Trial Supplies, is an end-to end clinical supply planning leader that provides relevant expertise in a fast paced biotech environment. This individual will perform strategic, clinical supply management for its clinical development programs (phase 1, 2, 3) and support commercial launch, and will report to the SVP, Technical Operations. The Senior Director works internally with other members of Global Supply Chain (GSC) and other Crinetics functions - e.g., Clinical Development, Clinical Operations, Product Development & Manufacturing (PDM), Quality Assurance, Regulatory, and Project Management Office - to develop and formulate supply chain strategies, meet project deliverables, solve business problems and create a competitive advantage. This position includes all elements of the clinical supply planning from the protocol design through manufacturing to the ultimate distribution and inventory management of clinical supplies at clinical sites worldwide. The individual has an expert working knowledge of clinical supply chain best practices and experience working with a GxP environment. The individual will also have strong, cross-functional, multi-cultural awareness and communication skills to lead in a fast-paced, global company. The Technical Operations team is highly collaborative with a global network of highly qualified Contract-Research Organizations (CROs) and Contract Development and Manufacturing Organizations (CDMOs). Essential Job Functions and Responsibilities: These may include but are not limited to: * Serve as the clinical supply lead on CMC sub-teams and Clinical Operations teams especially for complex development programs - e.g., late phase, acquisition, partnership/alliance, new modality, etc.). * Lead the development and execution of overall clinical supply strategy and management for clinical development program(s), including management of investigational medicinal product (IMP) for assigned global trials and domestic trials. * Oversee and support clinical study planners in a matrix environment. Facilitate issue and risk identification, mitigation, resolution and communication. * Drive decision-making at cross-functional teams (ClinOps, PDM sub-teams) supporting the long-term vision. * Identify, manage and mitigate supply risks at clinical development program level. Lead and drive visible, impactful process improvements and change business and organizational imperatives. * Author, revise, and review standard operating procedures (SOPs), work instructions, and business policies. * Manage clinical supply budget of assigned clinical development program(s). * Review and approve statements of work, purchase orders, and invoices. * Influence (and at times drive) program allocations at partners, including contract manufacturing organizations (CMOs). * Oversee contract packaging and distribution vendor operations for Crinetics' sponsored ongoing and upcoming clinical trials, including budget, timelines, review of specifications, master and executed packaging records, labeling, distribution instructions, logistics, and QP interactions. * Ensure timely execution of domestic and international distribution of Clinical Trial Materials for all therapeutic programs. Plan appropriate inventory at warehouse and site levels and monitor drug supply usage, use date expiry, drug returns, field transfers, and destruction. * Forecast demands for clinical supplies and coordinate production and shelf-life extension with the Drug Product and Analytical team. * Select, implement, and manage IRT systems from set up to close out with Data Management and Clinical Operations. * Create and manage a global team of skilled professionals, mentoring them in all matters related to clinical supplies. * Develop strategic project and resource plans for company clinical supplies, setting clear outcomes and deliverables, and provide high level guidance to senior management on drug supply requirements. * Build and maintain a network of CROs, CDMOs, and packaging and distribution facilities appropriate to each phase of development. * Establish supply chain strategy for commercially available comparators, rescue medications, ancillary medications, etc. to support domestic and international clinical trials. * Integrate and influence cross-functional internal and external teams across Technical Operations, Clinical Operations, Regulatory Affairs, and Quality Assurance to deliver clinical trial materials fit for their intended use and in compliance with local compliance and regulatory standards. * Review global clinical labels, pharmacy manuals, and clinical supplies Standard Operating Procedures. * Manage the scope, cost, timelines, and quality of integrated clinical trial supplies plans. * Contribute to preparation of regulatory filings (including INDs, IMPDs, NDAs, briefing packages, and other regulatory dossiers). * Support Quality Assurance with implementation and management of the quality system and compliance activities, including inspections by regulatory agencies and audit functions. * Other duties as assigned. Education and Experience: Required: * A bachelor's degree in in life sciences, engineering, business, or relevant discipline with at least 15 years of related technical experience (or a master's degree with at least 13 years of related technical experience) in the pharmaceutical industry with increasing responsibility in clinical supplies management, plus a minimum of 10 years in a supervisory role. * Previous experience in rare diseases/oral solid dosage forms is a plus. * Prior experience building a global clinical supplies organization is highly desirable. * Import and export management of drug substance and drug product, including selection of importer of record and familiarity with VAT strategies. * Understanding of CGMP and CGCP requirements, compendia testing, and ICH and regulatory guidelines including stability data requirements. * Demonstrated ability to collaborate in a cross-functional environment. * Strong experience in project management best practices. * Excellent interpersonal and communication skills (written and oral). This includes the ability to effectively and accurately present data to peers, management, and external partners and training material to investigators/site personnel. * Experience with preparation of regulatory documents is desired. * Excellent ability to work in a goal and team-oriented setting and to handle competing priorities. * Flexibility within a rapidly changing environment and high attention to details. * Well-developed organizational skills and the ability to thrive under pressure. * Well-versed in industry trends, emerging business processes and technologies. Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 20% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Salary Range The salary range for this position is: $216,000 - $270,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Executive Director, Corporate Legal & Governance Counsel will serve as a senior legal leader responsible for advising on global corporate governance, securities law compliance, and strategic transactions. The ideal candidate should possess exceptional leadership skills, strong work ethics, sound judgment, excellent communication and interpersonal skills, proactive problem-solving abilities, and thrive in a fast-paced environment. Essential Job Functions and Responsibilities: Serve as a primary legal advisor to the CFO, Head of Investor Relations, and Finance team on corporate transactions, disclosures and public-company obligations. Draft, review and counsel on the company's SEC filings (Forms 10-K, 10-Q, 8-K, Proxy Statement), and other periodic/occasional disclosures under U.S. securities laws and applicable stock-exchange rules. Oversee and advise on the company's insider-trading compliance program, Section 16 reporting, 10b5-1 plans, trading windows, blackout periods and pre-clearance frameworks. Manage the company's public-company corporate governance framework: prepare materials for the Board of Directors and its committees (e.g., audit, compensation, nominating and governance), annual meeting process, minutes, resolutions, charter review, governance records and help ensure best practices. Collaborate closely with the Finance team and outside counsel on financing, capital markets, debt/equity issuances, share repurchases and other strategic corporate transactions. Take ownership of disclosure controls and procedures, internal controls over financial reporting and other processes-regularly evaluate, refine and enhance these processes. Monitor and assess developments in U.S. federal and state securities laws, stock-exchange listing standards, corporate governance trends, proxy advisory-firm developments and global disclosure/regulatory regimes - interpret their impact for the business and recommend appropriate responses. Develop and maintain strong cross-functional relationships with internal stakeholders (finance, controllership, tax, internal audit, treasury, investor relations, communications, R&D, commercial) and external stakeholders (independent auditors, banks, proxy advisors, outside counsel) to align legal, disclosure and governance strategies. Set priorities, manage performance and budget for the oversight of outside counsel. Provide substantive legal support for other corporate-law matters (including subsidiary governance, inter-company agreements, global stock plans, executive compensation) and assist the Chief Legal Officer and broader Legal team as needed. Champion the company's compliance culture: translate legal/regulatory requirements into pragmatic business guidance, deliver training, drive awareness of governance and disclosure obligations, and foster ethical decision-making across the enterprise. Additional Responsibilities include Global Expansion, Tax & Intercompany Matters including but not limited to: Support the company's international expansion and global commercialization initiatives, providing legal guidance on the formation, governance, and maintenance of foreign subsidiaries, cross-border transactions, and compliance with international corporate, securities, and anti-corruption laws. Partner with Finance teams to structure and document intercompany arrangements (e.g., cost-sharing, services, IP licensing, and transfer-pricing agreements) consistent with global tax strategy, corporate policies, and regulatory requirements. Advise on cross-border cash management, capital contributions, and financing arrangements, ensuring alignment with global tax efficiency, local regulatory restrictions, and disclosure obligations. Coordinate with regional legal and external advisors to address country-specific legal, governance, and compliance requirements as the company expands into new markets, launches commercial entities, or transitions from clinical to commercial operations internationally. Oversee or support legal due diligence and integration activities for international corporate restructurings, affiliate transactions, and global operational readiness in collaboration with R&D, Commercial, and Supply Chain functions. Other duties as assigned Education and Experience: Required: Juris Doctor degree from an accredited law school and minimum of 13 years of post-law school experience in the biotech/pharma sector A combination of law firm, in-house (pharma/biotech) experience strongly preferred. Significant corporate securities law, international expansion, and public company experience serving as in-house counsel for a pharmaceutical or biotechnology company. Leadership: a minimum of 12 years of experience as a supervisor with strong leadership skills and experience managing and developing high-performing teams. Ability to influence senior executives and cross-functional teams. Strong business acumen and understanding of pharmaceutical business. Demonstrated ability to align global legal and compliance strategies with broader business goals In addition to top-notch legal skills and a strong ethical center, excellent interpersonal, strategic thinking, communication and organizational skills Excellent verbal and written communication skills, with the ability to convey complex legal concepts to non-legal stakeholders Proven track record of successfully managing outside counsel, handling multiple priorities simultaneously, and delivering results under tight deadlines Highly proficient in Microsoft Office Suite, SharePoint, Microsoft Teams and other programs, particularly Excel and PowerPoint Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 10% of your time, approximately once per quarter. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Salary Range The salary range for this position is: $264000 - $33000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Environmental Health & Safety (EH&S) Specialist is responsible for supporting compliance with all applicable environmental, health, and safety regulations. This role involves promoting adherence to EHS programs, conducting risk assessments, assisting with incident investigations, and role-modeling a culture of safety and environmental stewardship. The EH&S Specialist collaborates with cross-functional teams to help ensure safe operations and maintain regulatory compliance. Essential Job Functions and Responsibilities: These may include but are not limited to: * Ensure compliance with local, state, and federal regulations (e.g., OSHA, Cal/OSHA, EPA, DOT). * Assist in delivering EHS training programs for employees and contractors. * Support EHS-related committees such as the Safety Committee, Emergency Response Team, First Responders, and Spill Response Team. * Conduct risk assessments and assist in implementing mitigation strategies for job-related hazards. * Respond to and assist in investigating incidents, including injuries, chemical/biological spills, and near-misses. * Document incident reports and maintain tracking systems to ensure timely follow-up and resolution. * Conduct internal EHS inspections and support third-party audits. * Assist with external audits and inspections, ensuring corrective actions are documented. * Ensure hazardous waste and materials transportation complies with applicable laws. * Assist with updating Safety Data Sheets (SDS) and chemical inventory. * Collaborate with Facilities to support emergency events and site-specific emergency action plans. * Maintain accurate EHS records and assist in preparing reports for internal and external stakeholders. * Promote safe work practices through ergonomic assessments and safety awareness campaigns. * Perform additional tasks as needed to support health and safety, environmental protection, and business continuity. * Uphold the company's reputation through regulatory compliance, ethical conduct, and proactive risk awareness. Education and Experience: Required: * Bachelor's degree in Environmental Science, Occupational Health, Safety Management, or related field. * 2+ years of experience in EH&S roles, in biotech or laboratory environments. * Strong knowledge of OSHA, EPA, DOT, and Cal/OSHA regulations. * Experience conducting risk assessments, audits, and incident investigations. * Excellent communication and organizational skills. * Experience with hazardous waste management and emergency response planning. * Proficiency in EH&S reporting systems and excellent PC-based computer skills including Windows and MS Office. Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 5% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Salary Range The salary range for this position is: $79,000 - $99,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: Crinetics is seeking a highly experienced and strategic Director, Privacy Legal Counsel to lead and oversee the company's global privacy program. Reporting to the Chief Legal Officer, this role is critical in ensuring compliance with United States and international privacy regulations, standards, and industry best practices. The Director will be Crinetics' privacy subject-matter expert, advising on privacy, data protection, cybersecurity, and data governance initiatives across R&D, clinical development, IT, HR, and commercial operations. The ideal candidate will bring deep experience counseling life-sciences organizations, a sophisticated understanding of global privacy frameworks, and the ability to translate complex legal requirements into actionable business guidance that supports innovation, patient trust, and ethical data use. Essential Job Functions and Responsibilities: These may include but are not limited to: * Lead, design, implement, and maintain a comprehensive global privacy and data protection program, including policies, standards, procedures, and controls that align with U.S. and international regulations and industry best practices. * Serve as the company's primary advisor and subject-matter expert on privacy, data protection, cybersecurity, and data-use ethics across all business functions, including clinical development, research, pharmacovigilance, HR, IT, and commercial operations. * Provide practical, timely, and strategic legal advice on privacy and data-security issues impacting research, development, and commercialization activities, balancing risk mitigation with operational efficiency. * Counsel on privacy and data-protection considerations throughout the clinical-trial lifecycle, including informed consent, pseudonymization and de-identification, secondary data use, and cross-border data transfers involving CROs, investigators, vendors, and regulators. * Support compliant data-use practices for real-world evidence, pharmacovigilance, patient-support programs, and digital health platforms, ensuring lawful processing and appropriate safeguards for sensitive health information. * Advise on privacy, data-governance, and ethical considerations in connection with artificial intelligence (AI), machine learning (ML), and emerging digital technologies, including transparency, fairness, and explainability requirements under evolving AI and data-use frameworks (e.g., EU AI Act, Colorado AI Act). * Monitor, interpret, and implement strategies to comply with emerging privacy and AI laws, including the GDPR, HIPAA, CCPA/CPRA, Colorado Privacy Act, Virginia Consumer Data Protection Act, Washington My Health My Data Act, Oregon Consumer Privacy Act, and other state, federal, and global regulations. * Oversee Privacy Impact Assessments (PIAs) and Data Protection Impact Assessments (DPIAs) for systems, clinical programs, and data-processing activities, and advise on remediation and risk-mitigation measures. * Draft, review, and negotiate data-protection and privacy provisions in vendor, commercial, collaboration, and clinical research agreements, ensuring alignment with company policies and global legal requirements. * Provide legal support for cross-border data transfers, including evaluation and implementation of Standard Contractual Clauses (SCCs), Transfer Impact Assessments (TIAs), and other transfer mechanisms. * Partner with Compliance, IT, and Information Security to establish governance frameworks for data classification, access, retention, and disposal, promoting "privacy by design" and "security by default." * Play a leadership role in incident response investigations involving potential privacy or data-security events, including assessing regulatory notification obligations and advising on root-cause and remediation efforts. * Develop and deliver enterprise-wide privacy training and communications to strengthen understanding of data-protection principles, regulatory requirements, and ethical data handling across the organization. * Build strong cross-functional relationships with R&D, clinical, IT, HR, Compliance, and Commercial teams to foster a proactive, collaborative, and accountable privacy culture. * Other duties as assigned Education and Experience: Required: * Juris Doctor degree from accredited law school required * 10+ years of relevant experience, with at least 5+ years in the biotechnology, pharmaceutical, or healthcare industry focusing on privacy and data protection. * Leadership: a minimum of 8 years of experience as a supervisor with strong leadership skills and experience managing and developing high-performing teams. Ability to influence senior executives and cross-functional teams. * Deep knowledge of HIPAA, GDPR, U.S. federal and state privacy laws, and global data-transfer frameworks. * Proven experience developing and operationalizing privacy programs and managing complex, cross-functional privacy issues. * Strong contract drafting and negotiation skills related to research agreements, particularly vendor, data-processing, and clinical agreements. * In addition to top-notch legal skills and a strong ethical center, excellent interpersonal, strategic thinking, communication and organizational skills * Ability to build consensus with diverse stakeholders and form strong, collaborative working relationships * Ability to handle multiple projects in a fast-paced environment and exercise sound legal judgment * In-house experience with product counseling, compliance, litigation, and regulatory teams * Experience with commercial or consumer contracts involving data privacy * High level of business acumen, excellent contract drafting and negotiation proficiency Preferred: * CIPP/US, CIPM, or equivalent privacy certification. * AIGP or similar AI governance credentials. * Experience supporting AI-driven innovation. Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 10% of your time, approximately once per quarter. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Salary Range The salary range for this position is: $170,000 - $213,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Senior Process Chemist 2, Drug Substance Development, will be responsible for designing, optimizing, and scaling synthetic chemical processes for active pharmaceutical ingredients (APIs). This role will work closely with cross-functional teams to ensure that new processes are efficient, cost-effective, safe, and compliant with regulatory standards for large-scale manufacturing. This position will report to the Director, Drug Substance Development CMC. The Technical Operations team is highly collaborative and operates with a global network of highly qualified Contract-Research Organizations (CROs) and Contract Development and Manufacturing Organizations (CDMOs). This position will be an integral part of the company's effort to discover and develop small molecule therapeutics for rare endocrine disorders. This is a unique opportunity to work with a proven and well-funded drug discovery and development company in the heart of San Diego's biotechnology community. This position will be located in San Diego. Essential Job Functions and Responsibilities: These may include but are not limited to: * Develop and optimize synthetic routes for APIs from lab to pilot-plant scale. * Collaborate with analytical chemistry and formulation teams to characterize intermediates and final products. * Conduct risk assessments to ensure safety and environmental compliance. * Generate process documentation, including batch records, SOPs, and technical reports. * Explain complex scientific and technical concepts, influencing others to adopt new points of view. * Manage daily activities of a small functional group, identifying ways to improve efficiencies and best practices within the work unit. * Contribute to key reviewed scientific/technical documents, expert reports, or patents that enhance the company's intellectual capital. * Evaluate scalability and robustness of chemical processes using Design of Experiments (DoE). * Lead technology transfer of processes to manufacturing and contract development organizations (CDMOs). * Troubleshoot process issues and implement improvements for cost, yield, and quality. * Stay up-to-date on regulatory requirements, including cGMP and ICH guidelines. * Support regulatory filings (INDs, IMPDs, NDAs, briefing packages, and other regulatory dossier) as needed. * Other duties as assigned. Education and Experience: Required: * Ph.D. in organic chemistry or related field, with a minimum of 5-8 years of relevant hands-on experience in pharmaceutical, biotech laboratory, or CDMOs. (Masters with 13 years of experience or Bachelors with 15 years of experience may be considered). * Strong background in organic synthesis, reaction mechanisms, and crystallization techniques. * Extensive expertise in conducting chemical reactions as a process chemist, with a solid understanding of laboratory design to facilitate commercial route development. * Familiarity with scale-up principles and pilot-plant operations. * Knowledge of process analytical technology (PAT) and Quality by Design (QbD). * Proficient in scientific software (e.g., ChemDraw, MATLAB, or similar). * Significant and direct work experience with instruments used in laboratories in analytical techniques such as HPLC/UPLC, and solid-state characterization tools, including DSC, TGA, DVS, XRPD, microscopy, etc. * Knowledge of cGMP requirements and regulatory guidance (FDA, ICH). * Excellent written and oral communication skills, including drafting and reviewing technical documents, and the ability to effectively and accurately present data to peers, management, and external partners. * Excellent ability to work in a goal and team-oriented setting and handle competing priorities. * Flexibility within a rapidly changing environment and high attention to detail. * Well-developed organizational skills and the ability to thrive under pressure. * Intermediate to advanced software skills (e.g., Microsoft Excel, PowerPoint, MS Project). Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at a desk for a long period of time; intermittently answer the telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Travel: You may be required to travel for up to 10% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Salary Range The salary range for this position is: $134,000 - $167,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Scientist 1 will be responsible for contributing to the success of Crinetics' growing drug discovery projects and working within the Chemistry team. This individual will be responsible for both the design and synthesis of small-molecule drug candidates and should be highly proficient in the analysis of diverse data sets to build/drive Crinetics's medicinal chemistry strategy. Essential Job Functions and Responsibilities: These may include but are not limited to: Independently design, plan and execute synthesis, purification and submission of small molecule drug candidates and other molecules Troubleshoot chemistry problems independently Generate effective hypotheses to pursue, followed by experimental planning and execution Prepare and organize data for presentations and be able topresent written and oral reports to within the team and cross-functionally Participate in group discussion to exchange ideas among peers Prioritize of chemistry efforts to ensure efficient and timely progression of projects to meet company goals Conduct and coordinate lab tasking and responsibilities to ensure a smooth and safe operation. Stay current in both synthetic organic and medicinal chemistry literature to support company research objectives Education and Experience: Ph.D. in synthetic organic chemistry. Highly skilled in methodology development and multistep synthesis with demonstration of excellent problem-solving skills Strong track record of achievement in synthesis of complex molecules with state-of-the-art knowledge of modern synthetic methodologies and analytical and purification techniques Proven track record of creative thinking and consistent delivery as demonstrated by publication/presentation/patent record Excellent written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, ability to interact within a multidisciplinary team Responds well to scientific challenges and applies significant rigor to their own work Proficient in using chemistry related software and database such as ChemDraw, SciFinder, Reaxys Laboratory experience with: Flash column systems, NMR spectroscopy, thin layer chromatography, handling pyrophoric materials, LC/MS. Position Location: Onsite role in San Diego, CA Technical Knowledge Required: Office Software Knowledge: Windows, MS Office (Outlook, Word, PowerPoint, Excel). Chemistry related software required: ChemDraw, Electronic notebooks, NMR Analysis Office Equipment: PC, scanners, voice mail and e-mail systems, and common office machines, or ability to be trained. Software Knowledge: Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 5% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Salary Range The salary range for this position is: $107,000 - $134,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California that develops much-needed therapies for people with rare endocrine diseases. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and robust pipeline across preclinical and clinical development. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully integrated endocrine company from discovery to patients. Come join our team as we transform the lives of others. Position Summary: The Senior Director, Pharmaceutical Development Team Leader (PDTL) is responsible for developing and leading the execution of comprehensive, compound-specific Technical Operations strategies to meet the global project team's (GPT) needs. This role provides leadership to interdisciplinary teams, managing multiple assets through various stages of development, and collaborates with various functional areas to achieve optimal development and business results. Essential Job Functions and Responsibilities: These may include but are not limited to: Develop, refine, update, and oversee Technical Operations project plans from multiple inputs, with emphasis on the alignment of these plans with strategic objectives, the decomposition of major objectives into discrete WBS-level work packages, the mapping of internal and cross-functional interdependencies, and the management of project risks. Perform detailed scenario planning where significant ambiguity is present and map out the scope, cost, timeline, and risk aspects of each scenario. Provide leadership to interdisciplinary matrix teams responsible for developing and executing compound-specific integrated Technical Operations strategies. Manage multiple assets from candidate nomination to commercial formulation and manufacturing processes. Represent the Technical Operations organization on GPTs and collaborate with Clinical, Commercial, Regulatory, and other functional areas to integrate Technical Operations plans/activities into GPT goals and objectives. Communicate and partner effectively with stakeholders to define and execute Technical Operations strategy for projects. Identify and escalate key issues and risks, as well as resource allocation needs. Critically review relevant documents, including Technical Operations regulatory submissions and briefing booklets. Promote best practices and lead improvement opportunities. Partner with the Corporate Development to support Due Diligence evaluations. Education and Experience: Required: MSc or PhD in a relevant technical/scientific discipline. 15+ years of CMC experience in all phases of development, including regulatory submission (IND, NDA/MAA, IMPD) experience with a strong track record of success. Broad and sound understanding of process chemistry, drug product development, and analytical development. Proven track record in CMC development of clinical stage programs. Experience in multiple modalities is preferred. Solid understanding of CMC integration with Non-Clinical and Clinical development, Quality, Regulatory, and Commercial areas. Demonstrated strong project management experience. Relevant strategic and tactical project leadership experience. Excellent verbal and written communication skills. Experience in leading empowered, highly collaborative matrix teams. Keen sense for value of investment and ability to manage ambiguity. Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 30% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Salary Range The salary range for this position is: $214,000 - $268,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: We are seeking a highly motivated and collaborative Principal Scientist with experience in GPCR pharmacology and drug discovery to join our growing and dynamic in vitro pharmacology team. A successful candidate will be responsible for providing in vitro pharmacology leadership for lead optimization campaigns, mechanism of action studies, and new target efforts in endocrinology. Essential Job Functions and Responsibilities: These may include but are not limited to: * Lead and manage a small team of junior scientists, promoting collaboration, efficiency, and innovative science. * Design, develop, validate, and execute in vitro assays that support drug discovery programs. * Conduct critical analysis and interpret data into meaningful understanding of small molecule ligand activity and mechanism of action. * Demonstrate high level of initiative to oversee, troubleshoot, and accurately perform data analysis in an environment that values scientific integrity and quality. * Conduct resource management to deliver critical in vitro pharmacology data to support multiple programs simultaneously. * Lead and/or provide in vitro pharmacology leadership role on cross-functional program teams. * Interpret and demonstrate effective written and oral communication of results to interdisciplinary teams. * Participate in the strategic planning of departmental growth and organization. * Lead external collaborations and outsourced studies. * Identify and evaluate new research targets within therapeutic areas of interest. * Author scientific publications and prepare technical reports to support regulatory submissions. * Ensure compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards. * Other duties as assigned. Education and Experience: Required: * Ph.D. in Pharmacology, Biochemistry, Biology, or related discipline with a minimum of 8 years of relevant experience. Applicants with BS or MS degrees must demonstrate a minimum of 18 years of significant and relevant experience. * At least 7 years of experience with drug discovery and small molecule pharmacology at therapeutically relevant GPCRs or related field. * Demonstrated technical proficiency in biochemical, cellular, and/or radioligand binding assay systems and ability to ensure highest quality of in vitro assay data. * Ability to independently determine in vitro pharmacologic methods and procedures to achieve Program goals. * Outstanding experimental design, problem-solving, and data analysis skills and the ability to independently establish in vitro pharmacologic approaches to achieve program goals. * Demonstrated practical experience and deep understanding of in vitro pharmacological theory, models, mechanisms, and experimental design, particularly with GPCRs * Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature. * Strong work ethic and enthusiasm for a mix of laboratory work and management in a dynamic environment. * Experience in management and daily supervision of scientific staff is highly preferred. * Experience in program management/leadership desired. * Strong written and verbal communication skills and ability to work effectively in a multidisciplinary team environment. * Experience with writing reports and technical regulatory documents * Must be detail-oriented, punctual, and reliable. * Ability to work in a fast-paced environment and adapt to change. Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 5% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Salary Range The salary range for this position is: $158,000 - $197,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Executive Director, Corporate Legal & Governance Counsel will serve as a senior legal leader responsible for advising on global corporate governance, securities law compliance, and strategic transactions. The ideal candidate should possess exceptional leadership skills, strong work ethics, sound judgment, excellent communication and interpersonal skills, proactive problem-solving abilities, and thrive in a fast-paced environment. Essential Job Functions and Responsibilities: * Serve as a primary legal advisor to the CFO, Head of Investor Relations, and Finance team on corporate transactions, disclosures and public-company obligations. * Draft, review and counsel on the company's SEC filings (Forms 10-K, 10-Q, 8-K, Proxy Statement), and other periodic/occasional disclosures under U.S. securities laws and applicable stock-exchange rules. * Oversee and advise on the company's insider-trading compliance program, Section 16 reporting, 10b5-1 plans, trading windows, blackout periods and pre-clearance frameworks. * Manage the company's public-company corporate governance framework: prepare materials for the Board of Directors and its committees (e.g., audit, compensation, nominating and governance), annual meeting process, minutes, resolutions, charter review, governance records and help ensure best practices. * Collaborate closely with the Finance team and outside counsel on financing, capital markets, debt/equity issuances, share repurchases and other strategic corporate transactions. * Take ownership of disclosure controls and procedures, internal controls over financial reporting and other processes-regularly evaluate, refine and enhance these processes. * Monitor and assess developments in U.S. federal and state securities laws, stock-exchange listing standards, corporate governance trends, proxy advisory-firm developments and global disclosure/regulatory regimes - interpret their impact for the business and recommend appropriate responses. * Develop and maintain strong cross-functional relationships with internal stakeholders (finance, controllership, tax, internal audit, treasury, investor relations, communications, R&D, commercial) and external stakeholders (independent auditors, banks, proxy advisors, outside counsel) to align legal, disclosure and governance strategies. * Set priorities, manage performance and budget for the oversight of outside counsel. * Provide substantive legal support for other corporate-law matters (including subsidiary governance, inter-company agreements, global stock plans, executive compensation) and assist the Chief Legal Officer and broader Legal team as needed. * Champion the company's compliance culture: translate legal/regulatory requirements into pragmatic business guidance, deliver training, drive awareness of governance and disclosure obligations, and foster ethical decision-making across the enterprise. Additional Responsibilities include Global Expansion, Tax & Intercompany Matters including but not limited to: * Support the company's international expansion and global commercialization initiatives, providing legal guidance on the formation, governance, and maintenance of foreign subsidiaries, cross-border transactions, and compliance with international corporate, securities, and anti-corruption laws. * Partner with Finance teams to structure and document intercompany arrangements (e.g., cost-sharing, services, IP licensing, and transfer-pricing agreements) consistent with global tax strategy, corporate policies, and regulatory requirements. * Advise on cross-border cash management, capital contributions, and financing arrangements, ensuring alignment with global tax efficiency, local regulatory restrictions, and disclosure obligations. * Coordinate with regional legal and external advisors to address country-specific legal, governance, and compliance requirements as the company expands into new markets, launches commercial entities, or transitions from clinical to commercial operations internationally. * Oversee or support legal due diligence and integration activities for international corporate restructurings, affiliate transactions, and global operational readiness in collaboration with R&D, Commercial, and Supply Chain functions. * Other duties as assigned Education and Experience: Required: * Juris Doctor degree from an accredited law school and minimum of 13 years of post-law school experience in the biotech/pharma sector * A combination of law firm, in-house (pharma/biotech) experience strongly preferred. * Significant corporate securities law, international expansion, and public company experience serving as in-house counsel for a pharmaceutical or biotechnology company. * Leadership: a minimum of 12 years of experience as a supervisor with strong leadership skills and experience managing and developing high-performing teams. Ability to influence senior executives and cross-functional teams. * Strong business acumen and understanding of pharmaceutical business. * Demonstrated ability to align global legal and compliance strategies with broader business goals * In addition to top-notch legal skills and a strong ethical center, excellent interpersonal, strategic thinking, communication and organizational skills * Excellent verbal and written communication skills, with the ability to convey complex legal concepts to non-legal stakeholders * Proven track record of successfully managing outside counsel, handling multiple priorities simultaneously, and delivering results under tight deadlines * Highly proficient in Microsoft Office Suite, SharePoint, Microsoft Teams and other programs, particularly Excel and PowerPoint Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel for up to 10% of your time, approximately once per quarter. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Salary Range The salary range for this position is: $264000 - $33000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Senior Process Chemist 1, Drug Substance Development, will be responsible for designing, optimizing, and scaling synthetic chemical processes for active pharmaceutical ingredients (APIs). This role will work closely with cross-functional teams to ensure that new processes are efficient, cost-effective, safe, and compliant with regulatory standards for large-scale manufacturing. This position will report to the Director, Drug Substance Development CMC. The Technical Operations team is highly collaborative and operates with a global network of highly qualified Contract-Research Organizations (CROs) and Contract Development and Manufacturing Organizations (CDMOs). This position will be an integral part of the company's effort to discover and develop small molecule therapeutics for rare endocrine disorders. This is a unique opportunity to work with a proven and well-funded drug discovery and development company in the heart of San Diego's biotechnology community. This position will be located in San Diego. Essential Job Functions and Responsibilities: These may include but are not limited to: Develop and optimize synthetic routes for APIs from lab to pilot-plant scale. Collaborate with analytical chemistry and formulation teams to characterize intermediates and final products. Conduct risk assessments to ensure safety and environmental compliance. Generate process documentation, including batch records, SOPs, and technical reports. Evaluate scalability and robustness of chemical processes using Design of Experiments (DoE). Support technology transfer of processes to manufacturing and contract development organizations (CDMOs). Troubleshoot process issues and implement improvements for cost, yield, and quality. Stay up-to-date on regulatory requirements, including cGMP and ICH guidelines. Support regulatory filings (INDs, IMPDs, NDAs, briefing packages, and other regulatory dossier) as needed. Other duties as assigned. Education and Experience: Required: Ph.D. in organic chemistry or related field, with a minimum of 3 years of relevant hands-on experience in the pharmaceutical, biotech, or CDMO industry. (Masters with 11 years of industry experience or Bachelors with 13 years of industry experience may be considered). Strong background in organic synthesis, reaction mechanisms, and crystallization techniques. Familiarity with scale-up principles and pilot-plant operations. Knowledge of process analytical technology (PAT) and Quality by Design (QbD). Proficient in scientific software (e.g., ChemDraw, MATLAB, or similar). Significant and direct work experience with instruments used in laboratories in analytical techniques such as HPLC/UPLC, and solid-state characterization tools, including DSC, TGA, DVS, XRPD, microscopy, etc. Knowledge of cGMP requirements and regulatory guidance (FDA, ICH). Excellent written and oral communication skills, including drafting and reviewing technical documents, and the ability to effectively and accurately present data to peers, management, and external partners. Excellent ability to work in a goal and team-oriented setting and handle competing priorities. Flexibility within a rapidly changing environment and high attention to detail. Well-developed organizational skills and the ability to thrive under pressure. Intermediate to advanced software skills (e.g., Microsoft Excel, PowerPoint, MS Project). Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at a desk for a long period of time; intermittently answer the telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Travel: You may be required to travel for up to 10% of your time. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Salary Range The salary range for this position is: $123,000 - $154,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world's premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. Position Summary: The Director, Analytical Development will report to the Senior Director, Analytical Development and Quality Control. The Technical Operations is highly collaborative with a global network of highly qualified Contract-Research Organizations (CROs) and Contract Development and Manufacturing Organizations (CDMOs). This individual will be an integral part of the company's effort to discover and develop small molecule therapeutics for rare endocrine disorders and endocrine-related-tumors. This is a unique opportunity to work with a proven and well-funded drug discovery and development team in a small company environment in the heart of San Diego's biotechnology community. Essential Job Functions and Responsibilities: These may include but are not limited to: Establish, direct, and monitor implementation of appropriate Tech Ops testing methodology and specifications for raw materials, intermediates, excipients, active pharmaceutical ingredients (APIs) and drug products (DPs), with focus on oral dosage Lead analytical development activities of the assigned projects and deliver business results for CMC/Tech Ops Analytical Develop departmental processes to achieve department and corporate goals Focus on immediate and short-term ( Work closely with external CRO/CDMOs collaborators to c advance method development, qualification, transfer, and validation for API and DP for advanced programs Provide detailed review and approval for protocols, reports, and raw data for analytical method qualification/validation, release testing, and reference materials qualification Review and approve analytical methods, specifications, change controls, deviations, investigations, out-of-trend and/or out-of-specification reports Ensure consistent implementation of analytical methods and product specifications at CDMOs/contract laboratories Work in close collaboration with and supports other members of the Tech Ops team responsible for API and DP development and support to management, as necessary Identify, evaluate, select, and develop relationships while actively managing external parties (CROs, CMOs, RM suppliers, consultants, etc.). This includes writing, reviewing, and managing requests for proposals, statements of work, contracts, budgets and timelines, and oversight on due diligence efforts Author and review CMC sections of regulatory filings (including INDs, IMPDs, NDAs, briefing packages, and other regulatory dossiers) Author and/or review departmental related Standard Operating Procedures and guidelines, technical reports, specifications, corrective/preventative actions, change controls, investigations, and deviations to ensure compliance with cGMPs and company standards Effectively work with RA and QA on quality system to ensure up-to-date procedures, adherence, and compliance of vendors with cGXP regulations Participate as CMC/Tech Ops subject matter expert in quality audits Identify and promote opportunities to streamline in-house CMC analytical development activities Provide leadership, career management and personal development to direct reports Recruit and develop top talent. Align team to needs of the business. Other projects (impurity identification and characterization, etc.) as deemed appropriate Education and Experience: Required: Bachelor's degree in Analytical Chemistry or related field with 12+ years of progressively responsible experience in analytical development in biopharmaceutical development, or an advanced degree (MS or PhD) with a minimum of 10 years of relevant technical and industry experience. A minimum of 8+ years in a supervisory role Work experience in a biotech or pharma company (with a focus on small molecules in late phase of development) and extensive experience in oral solid dosage forms is desired Experience in relationship management of Contract Research Organization and contract laboratories Extensive technical experience in analytical testing, method development and phase appropriate qualification/validation, characterization, and support of stability programs for small molecule API and oral DPs Proficient with techniques that include but are not limited to HPLC, GC, KF, IC, LC-MS, UV-Vis, XRPD, microbial Proficient in at least two other areas of pharmaceutical development (e.g., solid state analysis, physical characterization, drug product dissolution) Successful record of managing analytical activities and overcoming challenges Experience in reviewing and analyzing release and stability data for trending, shelf-life and specification setting Solid understanding of CGLP and CGMP requirements, compendia testing, ICH, FDA, and EMA guidelines with a focus on product development and manufacture, including stability requirements Extensive knowledge of CGMP, quality systems and industry standards and thorough understanding of requirements for products in late phase of development Excellent interpersonal and communication skills (written and oral). This includes the ability to effectively and accurately present data to peers, management, and external partners. Excellent ability to work both independently and in a matrix team environment, in a goal and team-oriented setting and handle competing priorities Ability and interest in mentoring and/or managing others Flexibility within a rapidly changing environment and high attention to detail Well-developed organizational skills and detail oriented Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities. Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply. Travel: You may be required to travel up to 20%. Equal Opportunity Employer: Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws. Total Compensation: The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process. Salary Range The salary range for this position is: $182,000 - $227,000. In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.