TEMP Scientist I, Bioconjugation
Cytomx job in South San Francisco, CA
Description Headquarters Location: South San Francisco, CA Candidate Location: Hybrid Travel Required: NoneReports To: Senior Scientist II, Protein Sciences & Early CMCDepartment: Protein SciencesPosition Type: Temporary (12 months), Non-Exempt About CytomX Therapeutics: CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel PROBODY therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX's robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engagers, and immune modulators such as cytokines. CytomX's clinical-stage pipeline includes CX-2051 and CX-801. Learn more at *************** Who You Are and What You'll Do:We seek a highly motivated individual with strong chemistry and biologics background to evaluate the drug conjugate technologies to generate cutting-edge PROBODY drug conjugates for the treatment of multiple cancer indications. The successful candidate will work as a TEMP Scientist I for 12 months in the Protein Sciences & Early CMC Department and contribute to the development of robust research scale conjugation process and innovative protein production and purification strategies to support multiple discovery programs. The individual will have the opportunity to work closely with Process Sciences group to transition PROBODY drug conjugates into clinical development and provide support for ongoing clinical programs. Job Responsibilities:
Generate PROBODY drug conjugates (PDC) to support all discovery PDC programs at CytomX
Develop robust research scale conjugation process for various random and site-specific conjugation technologies.
Develop analytical methods to fully characterize PDCs.
Develop analytical methods for in-process testing of PDCs.
Develop strategies to improve the production, purification and characterization of various formats of PROBODY molecules
Work collaboratively with members of Oncology Research and provide technical and scientific guidance.
Work collaboratively with Process Sciences group to transition the conjugation process and analytics from discovery to development and support ongoing programs.
Collaborate with discovery, protein engineering and pharmacology to provide therapeutic protein candidates of appropriate quality for use in in vitro and in vivo studies.
Organize data and communicate results in internal and external scientific meetings
Minimum Qualifications:
PhD in Biochemistry or Chemistry or related discipline with 2+ years of experience in the biotechnology or biopharma industry or MS in Biochemistry or Chemistry with 5+ years of experience in the biotechnology or biopharma industry
Experience with conjugation chemistry used in ADC discovery is required
Expertise in developing high-throughput conjugation methods is required.
Experience in bioconjugation methods (lysine, inter-chain cysteine and/or site-specific cysteine and other) is required.
Experience in synthesis, purification and characterization of ADCs on research scales (0.5 - 15 mg) and medium scales (100 - 500 mg) is required.
Experience in development of purification strategies to separate conjugated and unconjugated proteins and antibodies using various chromatographic techniques and pertinent filtration processes is required.
Expertise in analytical and biophysical characterization of ADCs including HIC, SEC, RP-HPLC, CE-SDS, and ELISA is required.
Must have strong communication (oral and written) and presentation skills.
Preferred Qualifications:
Experience with ADC process development preferred
Experience with Linker-payload synthesis chemistry preferred
Experience in transitioning the ADCs from discovery to Development is preferred.
Experience in the production and purification of antibodies and bispecific molecules in various formats preferred
Experience in developing and executing procedures and protocols and preparing summary reports preferred.
How You Will Work:
Demonstrates collaboration and teamwork. Works well with others and understands that collaboration leads to better results.
Possesses strong communication skills. Communicates clearly, concisely, and professionally. Listens actively to build understanding. Excellent leadership and influencing skills.
Exhibits strong interpersonal skills and self-awareness. Builds and cultivates strong and enduring relationships with others. Acts with humility and understands own strengths and weaknesses.
Shows continuous improvement and a commitment to self-management and development. Operates with a continuous improvement mindset and continuously seeks to expand own knowledge and capabilities. Adaptable and resilient with problem solving orientation
Demonstrates a patient focus. Puts the patient first in actions and decisions taken.
Intellectually curious, enthusiastic, creative
Compensation, Benefits, and So Much More
The expected salary range for this role based on the primary location for this position in the SF Bay Area in California is $57.00 - $67.00 per hour. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job-related factors permitted by law.
A great environment where we work collaboratively, leverage each other's strengths, and work toward a shared vision with our common goals of doing the best thing for patients.
A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX.
A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work / life balance for permanent employees only.
Conditions of Employment
Background investigations are required for all positions at CytomX, consistent with applicable law.
CytomX's Commitment to Diversity, Equity, Inclusion, and Belonging (DEIB) CytomX believes that DEIB helps drive our success, and we encourage candidates from all identities, backgrounds, and abilities to apply. We are an equal opportunity employer committed to building an inclusive, innovative work environment with employees who reflect our values and ultimately, serve our patients. Therefore, in all aspects of the employment process, we provide employment opportunities to all qualified applicants without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity or expression, pregnancy, medical condition related to pregnancy, creed, ancestry, national origin, marital status, genetic information, or military status, or any other protected status in accordance with applicable law. Further, we are committed to the full inclusion of all qualified individuals. As part of this commitment, we (and the agencies we work with) will assist individuals who have a disability with any reasonable accommodation requests related to employment, including completing the application process, interviewing, completing any pre-employment testing, participating in the employee selection process, and/or to perform essential job functions where the requested accommodation does not impose an undue hardship. If you have a disability and require reasonable accommodation, or need other assistance in applying for or interviewing for this position, please direct your inquiries to Human Resources, at [email protected] Notice to Recruiters/Staffing AgenciesRecruiters and staffing agencies should not contact CytomX Therapeutics through this page. We require that all Recruitment Vendors (e.g., search firms, recruitment agencies and staffing companies) have a fully executed, formal written agreement on file with CytomX prior to submitting candidates. Any resumes submitted through the website or directly by Recruitment Vendors will be considered unsolicited. Unsolicited vendor submissions do not constitute any actual or implied contract with CytomX, and CytomX will not be responsible for any purported fees. For more information, please contact our HR team at [email protected]
Please review our
Applicant Personal Information Processing Notice
to understand what types of personal information we collect from job applicants and why we process such information.
Auto-ApplyStrategic Partnerships Associate - Drive Pharma Alliances
Redwood City, CA job
A HealthTech startup in Redwood City seeks a Strategic Partnerships Associate to manage and build partnerships with pharmaceutical clients. A successful candidate will have 2+ years in investment banking or strategy consulting, strong Excel and PowerPoint skills, and excellent communication abilities. Join a fast-growing company focused on improving healthcare access and experiences for patients and pharmacists.
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Registered Nurse (RN) - Recovery
Orinda, CA job
Join our dedicated healthcare team where compassion meets innovation! As a Registered Nurse with us, you'll have the opportunity to make a meaningful impact in patients' lives while enjoying a supportive work environment that fosters professional growth and work-life balance. Ready to be a vital part of our mission? Apply today and bring your passion for nursing to a place where it truly matters!
At San Ramon Regional Medical Center, we understand that our greatest asset is our dedicated team of professionals. That's why we offer more than a job - we provide a comprehensive benefit package that prioritizes your health, professional development, and work-life balance. The available plans and programs include:
Medical, dental, vision, and life insurance
401(k) retirement savings plan with employer match
Generous paid time off
Career development and continuing education opportunities
Health savings accounts, healthcare & dependent flexible spending accounts
Employee Assistance program, Employee discount program
Voluntary benefits include pet insurance, legal insurance, accident and critical illness insurance, long term care, elder & childcare, auto & home insurance
Note: Eligibility for benefits may vary by location and is determined by employment status
Shift: Rotate
Job type: Full Time
Hours:
Position Summary:
Provides direct patient care to pediatric through geriatric patient populations. Addresses the psychosocial, physical and general aspects of care related to the surgical environment. Responsible for monitoring the patient's physiological status in the immediate postoperative period. Communicates with the surgeon and anesthesiologist about patient conditions and receives direction for patient management. Intercedes to maintain optimum homeostasis.
Minimum Education:
Bachelor of Science in Nursing preferred
Minimum Experience/Skills:
Minimum one (1) year current work experience in the Post Anesthesia Care Unit (PACU) or recent three (3)
years of ICU/CCU/ED experience.
Licenses/Certificates/Credentials:
Current CA Registered Nurse licensure
Current BLS certification for Health Care Providers (AHA certified)
Current ACLS certification (AHA certified)
Current PALS certification (AHA certified)
Certification in specialty preferred
#LI-TB1
Employment practices will not be influenced or affected by an applicant's or employee's race, color, religion, sex (including pregnancy), national origin, age, disability, genetic information, sexual orientation, gender identity or expression, veteran status or any other legally protected status. Tenet will make reasonable accommodations for qualified individuals with disabilities unless doing so would result in an undue hardship.
Tenet participates in the E-Verify program. Follow the link below for additional information.
E-Verify: *****************************
The employment practices of Tenet Healthcare and its companies comply with all applicable laws and regulations.
**********
Employment practices will not be influenced or affected by an applicant's or employee's race, color, religion, sex (including pregnancy), national origin, age, disability, genetic information, sexual orientation, gender identity or expression, veteran status or any other legally protected status. Tenet will make reasonable accommodations for qualified individuals with disabilities unless doing so would result in an undue hardship.
Auto-ApplyService Coordinator RN
Pleasanton, CA job
/RESPONSIBIILITIES The Service Coordinator - Registered Nurse provides STAR Kids Members with initial and ongoing assistance by identifying, selecting, obtaining, coordinating, and using Covered Services and other supports to enhance the Member's well-being, independence, integration in the community, and potential for productivity. The SC-RN provides a holistic evaluation of the Member's individual dynamics, needs and preferences while providing education and health-related information to the Member, the Member's Legal Authorized Representative (LAR), and the Member's Support Network. Responsible for the coordination of STAR Kids members' covered and non-covered services, including both acute and long term services and supports (LTSS), while meeting the Member's physical, behavioral, functional, and psychosocial needs. Complies with University Health System's and CFHP's policies, procedures and protocols for establishing and maintaining good working relationships with co-workers, Health System employees, patients and guests.
EDUCATION/EXPERIENCE
BSN is preferred. Four (4) recent years of clinical experience preferred, which may include service coordination, case management, quality management or managed care experience. Working knowledge of ICD10, CPT4 coding, InterQual/M&R criteria, Texas Department of Insurance HMO standards, LTSS, and NCQA standards is preferred. Supervisory experience is preferred.
LICENSURE
RN must possess current licensure with the Texas State Board of Nurse Examiners. Current certification from an appropriate professional agency, such as the Case Management Society, is preferred.
Compliance and Privacy Officer
San Leandro, CA job
PLEASE READ THIS JOB ANNOUCEMENT IN ITS ENTIRETY. An Alameda County Job Application is required to be considered for ALL County recruitments.
Compliance and Privacy Officer
Alameda County Health, Behavioral Health Department is recruiting for its next:
Compliance and Privacy Officer
$140,088.00-$170,289.60 Annually
Placement within this range is dependent upon qualifications.
Plus, an excellent benefits package!
This is a provisional recruitment.
*For a provisional appointment, a civil service exam is not required. However, to obtain a regular position, the appointee will need to compete successfully in a County Exam when open.
This position requires CA residency.
Please do not hesitate to contact Tyler (*********************), if you have any questions regarding the position or recruitment process.
About Us
As part of Alameda County Health, the Behavioral Health Department supports people with Medi-Cal and without insurance living with serious mental illness and substance use conditions along their path toward wellness, recovery, and resiliency. We provide services through a network of contracted mental health and substance use providers and administer the State's resources and training for behavioral health providers, case managers, and other healthcare professionals. We advocate for our patients and families and create space for personal engagement in their care.
We are outpatient specialists for mental health services for older adults and youth, substance use providers and treatment program specialists, advocates for quality improvement and patients' rights, and psychiatric and integrated health care providers.
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The POSITION
Under general direction, the designated program Compliance and Privacy Officer (CPO) plans, organizes, directs, monitors, and promotes an effective compliance and privacy program. This position ensures that departmental compliance programs are consistent with Alameda County Health (ACH) Standards of Conduct and core values, policies and procedures, and promote adherence to applicable federal and state laws to advance the prevention of healthcare fraud, waste, and abuse, while providing quality care and services to those served by ACH; oversee all ongoing activities related to the development, implementation, maintenance, and adherence to ACH's policies and procedures covering the privacy of and access to protected health information (PHI) in compliance with applicable state and federal laws; and performs other related work as required.
DISTINGUISHING FEATURES
This classification is in ACH and reports to the Chief Compliance and Privacy Officer and is responsible for the broad coordination of the Department's comprehensive healthcare compliance and privacy assurance program. The incumbent is responsible for coordinating and performing activities related to education, training, auditing, and investigations to ensure employee awareness and compliance with the program and may serve as project manager overseeing the development, implementation, and maintenance of related programs. This classification is distinguished from the Quality Assurance Administrator classification which has primary responsibility for day-to-day operational issues focused on the appropriate and effective delivery of services to clients whereby this classification is focused on broader departmental-wide compliance activities.
EXAMPLE OF DUTIES
NOTE: The following are the duties performed by employees in this classification. However, employees may perform other related duties at an equivalent level. Each individual in the classification does not necessarily perform all duties listed.
Implements and oversees the compliance and privacy program at departmental level to ensure the program meets the state/federal requirements and is aligned with the Alameda County Health Office of Compliance Services (OCS)
Acts as a consultative resource for the entity leadership and associates on compliance and privacy matters. Provides overall leadership on issues concerning compliance and privacy, including developing and implementing controls designed to ensure compliance with applicable laws, rules and regulations, accurate coding and billing, contract agreements and detect and deter fraud, waste, and abuse.
Identifies compliance vulnerabilities and risks, ensures that responses to reported concerns, alleged violations of the law, and/or conflict of interest, privacy, are reported in a timely appropriate, and consistent.
Ensures the implementation and maintenance of an effective healthcare compliance and privacy program for the entity which will include conducting relevant risk assessments and developing risk-based compliance work plans.
Maximize current strengths of the healthcare compliance and privacy program, identify and remedy gaps, proactively assess and address emerging compliance risks.
.Leads and participates in Compliance Team Projects and initiatives when requested (e.g., exclusion monitoring, triennial audits, etc.)
Oversees the implementation of corrective actions and monitoring in response to identified issues, audits, and annual work plan items.
Independently investigates or supervises the investigation of compliance or privacy concerns raised through the Agency Helpline or other reporting mechanisms.
Ensures distribution, implementation, and education regarding compliance policies and procedures, fraud waste and abuse, conflict of interest, code of conduct, billing and documentation, HIPAA privacy, and security awareness training.
Participates in the development and implementation of annual work plan, enterprise risk assessment, and management and aligns entity risk assessment with the Agency risk management plans.
Chairs or co-chairs the entity compliance and privacy committees and reports to the entity and Agency level leadership on compliance matters and progress on a regularly established frequency.
Maintains knowledge of rules and regulations (healthcare compliance, HIPAA, HITECH, state privacy laws, etc.) that impact specific service areas and the organization and acts as a subject matter expert to support and provide guidance to workforce members.
Develops and maintains collaborative relationships with leaders and stakeholders across the organization.
Identifies opportunities and supports efforts to build a culture of compliance.
Performs other duties as assigned.
Compliance and Privacy Officer
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MINIMUM QUALIFICATIONS
EDUCATION:
Possession of a bachelor's degree in public health, health care administration, social work, business administration, public administration, nursing, or a related field.
AND
EXPERIENCE:
The equivalent of four (4) years of responsible, professional-level healthcare compliance and recent experience in one or more of the following areas in a healthcare delivery setting consisting of community health clinics, hospitals, skilled nursing facilities, physician practices, health insurance plans, or other healthcare settings with a focus on regulatory compliance, quality assurance, health care law and/or administration, risk management and/or regulatory investigations.
CERTIFICATE:
Possession of a Healthcare Compliance Certificate issued by the Healthcare Compliance Association's Certification Board.
HOW TO APPLY
Please email your County of Alameda Job Application, resume and cover letter to:
Tyler (*********************)
The application template is available online on Alameda County's Online Employment Center @
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NEW USERS can click on “Fill out an application” to fill out an application template. Once the application is completed, candidates can click on the “Review” tab to “Print My Application” or “SAVE as PDF”. AN ALAMEDA COUNTY JOB APPLICATION MUST BE SUBMITTED TO ********************* TO BE CONSIDERED FOR THE POSITION.
Alameda County HCSA is enriched with a diverse workforce. We believe the best way to deliver optimal programs and services to our communities is to hire and promote talents that are representative of the communities we serve. Diverse candidates are strongly encouraged to apply.
BENEFITS
In addition to a competitive salary, employees also enjoy an attractive benefits package with the following elements:
For your Health & Well-Being
Medical and Dental HMO & PPO Plans
Vision or Vision Reimbursement
Basic and Supplemental Life Insurance
Accidental Death and Dismemberment Insurance
Flexible Spending Accounts - Health FSA, Dependent Care and Adoption Assistance
Short and Long -Term Disability Insurance
Voluntary Benefits - Accident Insurance, Critical Illness and Legal Services
Employee Assistance Program
For your Financial Future
Retirement Plan - (Defined Benefit Pension Plan)
Deferred Compensation Plan (457 Plan or Roth Plan)
Annual Cost of Living Adjustments as determined by bargaining units
May be eligible for Public Service Loan Forgiveness
May be eligible for up to $3,300 in annual County allowance
For your Work/Life Balance
12 paid holidays
4 Floating holidays and 7 Management Paid Leave days
Vacation and sick leave accrual
Vacation purchase program
Catastrophic Sick Leave
Employee Mortgage Loan Program
Group Auto/Home Insurance
Pet Insurance
Commuter Benefits Program
Employee Wellness Program
Employee Discount Program
Child Care Resources
*Benefit rates are dependent upon the management employee's represented or unrepresented classification.
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Senior / Lead SAP TM Solution Consultant
Mountain View, CA job
About Company:
Bristlecone is a supply chain and business analytics advisor, serving customers across a wide range of industries. Rated by Gartner as among the top ten system integrators in the supply chain space, we are uniquely positioned to solve contemporary business problems, with supply chain and analytics focus as our advantage. We have been a trusted partner and advisor to many leading, globally recognized companies such as Applied Materials, Exxon Mobil, Flextronics, LSI Logic, Mahindra, Motorola, Nestle, Palm, Qatar Petroleum, Ranbaxy, Unilever and Whirlpool and many others.
About the Role:
We're looking for an experienced Senior or Lead SAP Transportation Management (TM) Consultant to take charge of designing, implementing, and supporting SAP TM solutions across global logistics operations. This is a key leadership role in shaping end-to-end transportation and supply chain execution strategies using SAP TM - both standalone and embedded in S/4HANA.
If you're passionate about transforming transportation processes with cutting-edge SAP solutions and thrive in a collaborative, fast-paced environment, we'd love to hear from you.
✅ Key Responsibilities
Lead the design, configuration, and deployment of SAP TM solutions, ensuring seamless integration with SAP ECC/S4HANA, EWM, GTS, SD, and MM.
Partner with business stakeholders to analyze transportation needs and translate them into scalable SAP TM solutions.
Architect and optimize end-to-end transportation processes, including planning, execution, freight settlement, and carrier collaboration.
Provide expert guidance on TM master data, organizational structures, and configuration best practices.
Drive solution blueprinting, fit-gap analysis, functional design, and prototyping activities.
Design and implement interfaces with external logistics systems (e.g., 3PLs, carriers, TMS/OMS platforms).
Ensure system scalability, performance, and data integrity across all TM deployments.
Lead or contribute to SAP TM rollout projects, system migrations, and version upgrades.
Support continuous improvement through post-go-live enhancements and user enablement.
🎓 Qualifications
Bachelor's or master's degree in computer science, Engineering, Logistics, or a related field.
12+ years of hands-on SAP experience, with at least 5+ years focused on SAP TM (9.x or S/4HANA Embedded).
Deep expertise in key TM functionalities:
Transportation Planning & Optimization (manual and automated)
Carrier Selection & Tendering (EDI or SAP Collaboration Portal)
Freight Orders and Freight Bookings
Freight Charge Calculation and Settlement
Experience integrating SAP TM with SAP Event Management, PI/PO, or SAP GTS is highly desirable.
Strong understanding of industry-specific logistics (e.g., High Tech, Retail, Manufacturing).
Proven leadership in cross-functional teams and complex SAP projects.
Excellent communication, analytical, and stakeholder management skills.
Familiarity with Agile or hybrid project methodologies.
Privacy Notice Declarations for California based candidates/Jobs:: ********************************************************
Executive Director, Dialysis Services - San Antonio, TX (Relocation Assistance Available)
Pleasanton, CA job
: At University Health, we are dedicated to improving the health of our community through exceptional patient care, education, and innovation. Our team embodies a strong commitment to excellence, and we are seeking a dynamic and compassionate leader to guide our Dialysis Services team.
Position Overview :
As the Executive Director of Dialysis Services , you will oversee the administration and clinical direction of all dialysis services within our health system. This includes the renal clinic, inpatient dialysis programs, outpatient hemodialysis clinics, home dialysis modalities, and jail dialysis services. You will work closely with our Medical Directors to plan, organize, and lead the growth and efficiency of our dialysis services, ensuring compliance with regulatory standards and best practices in patient care.
Key Responsibilities :
Patient Care : Oversee the clinical services across multiple dialysis sites to ensure high-quality care in compliance with regulatory standards.
Human Resources : Supervise and mentor a team of clinical and support staff. You will play a key role in staff development, recruitment, and fostering a positive work environment.
Budget and Planning : Manage operational and capital budgets, ensuring efficient use of resources while meeting organizational goals.
Policy and Procedures : Develop and update clinical and administrative policies to ensure ongoing compliance with healthcare regulations.
Community Relations : Act as a liaison between University Health and the community, representing our dialysis services in various professional and public forums.
Qualifications :
Education : Bachelor's degree in Nursing (required); Master's degree (preferred)
Experience : At least 3 years of experience as a clinical nurse supervisor or director in dialysis services; leadership experience in managing multi-system dialysis operations is highly preferred.
Certifications : Current RN license in Texas; AHA BLS Healthcare Provider or Instructor card required.
Skills : Strong leadership abilities, excellent communication skills (Spanish/English bilingual a plus), and a dedication to patient-centered care.
Why University Health :
Impactful Work : Contribute to the health of our diverse community by leading one of the most critical healthcare services in the region.
Comprehensive Benefits : Competitive salary, comprehensive health plans, retirement options, and generous paid time off.
Relocation Assistance : Moving to San Antonio? We offer relocation support to help you settle into your new role and home.
Location :
San Antonio is a vibrant and growing city with a rich cultural history, a lower cost of living, and a high quality of life. With access to excellent schools, outdoor activities, and a strong sense of community, San Antonio is the perfect place to call home.
Senior Clinical Coordinator
Pleasanton, CA job
Senior Clinical Research Coordinator
Full-Time - Day Shift
Advance the Future of Clinical Research
Are you passionate about clinical research and ready to take your expertise to the next level? At University Health, we're seeking a Senior Clinical Research Coordinator to lead and support high-impact studies that shape the future of patient care. This is a unique opportunity to bring your clinical insight and research experience to a role that supports innovation, compliance, and excellence in human subject research.
What You'll Do
As a Senior Clinical Research Coordinator , you'll play a vital leadership role in the coordination and review of complex human subject research protocols. You will:
Evaluate and provide expert clinical and risk assessment on research protocols and procedures
Assist the Director with implementing a robust Human Subjects Protection Program
Serve as a departmental representative to internal and external research committees, including IRB and OHRP
Coordinate, monitor, and educate staff on best practices in research compliance and study execution
Support grant applications, budgeting, and program planning across diverse research initiatives
What We're Looking For
Education & Experience:
Required:
Bachelor's of Science in Nursing (BSN) from an accredited institution
Minimum 3 years of clinical research experience
Working knowledge of research methods and federal regulations for human subject research
Must possess or qualify to obtain CCRP or CCRA certification within 6 months of hire
Core Competencies:
Strong leadership and judgment in confidential, regulatory, and ethical matters
Ability to navigate complex research protocols with a sharp eye for detail
Confident representing the department in multi-institutional settings
Excellent communication, planning, and coordination skills
Why Join Us?
At University Health, you'll be part of a team that is passionate about research, innovation, and improving patient outcomes. We offer:
A dynamic, collaborative, and mission-driven environment
Opportunities to lead and influence policy at the institutional and national levels
A commitment to professional development and clinical research excellence
The chance to make a real impact on groundbreaking studies and healthcare transformation
Ready to Elevate Clinical Research?
Bring your skills, passion, and vision to a team that's shaping the future of healthcare research. Apply today to become our Senior Clinical Research Coordinator.
Hematology/Oncology
San Jose, CA job
Fulfilling the promise of medicine
The Permanente Medical Group, Inc. (TPMG - Kaiser Permanente Northern California) is one of the largest medical groups in the nation with over 10,000 physicians, 21 medical centers, numerous clinics throughout Northern and Central California, and an over 80-year tradition of providing quality medical care. We currently have the following opportunities:
HEMATOLOGIST/ONCOLOGIST: Antioch (part-time), Dublin, Fresno, Modesto, Oakland, Roseville (part-time), Sacramento Downtown, South San Francsico, Vallejo
HEMATOLOGIST/ONCOLOGIST - ONCOLOGY: Modesto, California
Full-time annual salary range is $470,040 to $500,040 plus additional potential incentives up to $41,570*. Reduced schedules with pro-rated compensation may be available. *Some incentive opportunities are estimates based on potential premium pay.
Per Diem Opportunities are also available throughout Northern & Central California. Per Diem pay range is $320 to $330 hourly.
With TPMG you'll benefit from:
Work-life balance focused practice, including flexible schedules and unmatched practice support.
We can focus on providing excellent patient care without managing overhead and billing. No RVUs!
We are committed to cultivating and preserving an inclusive environment for all physicians and employees.
Multi-specialty collaboration with a mission-driven integrated health care delivery model.
An outstanding electronic medical record system that allows flexibility in patient management.
We have a very rich and comprehensive Physician Health & Wellness Program.
We are Physician-led and develop our own leaders.
Professional development opportunities in teaching, research, mentorship, physician leadership, and community service.
EXTRAORDINARY BENEFITS:
Competitive compensation and benefits package, including comprehensive vision, medical, and dental
Interest Free Home Loan Program up to $250,000 (approval required)
Relocation Assistance up to $10,000 (approval required)
PSLF Eligible Employer
Malpractice and Tail Insurance
Life Insurance
Optional Long-Term Care Insurance
Paid holidays, sick leave, and education leave
Shareholder track
Three retirement plans, including a pension plan and 401(k)
For more information about these opportunities, our wage ranges, or to apply, please visit our website at: **************************************************************
For immediate consideration, kindly reply with your CV. Or contact Bo Chau, Physician Recruiter at ************** / call ************** with any questions.
We are an Equal Opportunity Employer and VEVRAA Federal Contractor
Connect With Us:
Facebook: @TPMGPhysicianCareers
LinkedIn: /company/the-permanente-medical-group/
Twitter: @TPMGDocCareers
Instagram: @TPMGPhysicianCareers
High-Throughput Screening Research Associate II, III (Biodesigner II, III)
San Francisco, CA job
Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply.
Job Description: High-Throughput Screening Research Associate II, III (Biodesigner II, III)
Responsibilities:
Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts.
Develop and execute molecular biology workflows such as vector design and cloning, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing.
Support cell culture activities and experiments in multiple cell lines, at small and large scales.
Design and execute cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays).
Engineer and characterize cell-based systems using synthetic biology tools and techniques.
Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity.
Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches.
Prepare summaries of data and present internally to colleagues and management.
Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records.
Author scientific reports and data summaries.
Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization.
Qualifications:
Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related field.
At least 2 years of industry wet lab experience.
Mammalian cell culture experience (culturing, transfecting and transducing cells, and DNA/RNA purification from cells).
Molecular biology expertise (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows)
Critical thinker with excellent communication skills who thrives in a multidisciplinary, fast-paced team environment.
Strong written and verbal communication skills.
Preference will be given to those who display:
High throughput screening assay development in an industry setting.
High motivation, with a strong work ethic and dedication to generating impact.
Attention to detail, with the ability to extract deep insights from data.
First-principles thinking, and an ability to refine one's intuition based on additional data.
Ability to go from ideation to data in an independent fashion.
Long-term personal vision with defined career goals.
High EQ with team-oriented thinking.
Experience with pooled, high-throughput screens using next-generation sequencing-based readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays.
Experience with CRISPR-Cas systems and/or gene editing and delivery technologies.
Experience preparing next-generation sequencing libraries (Illumina, PacBio, and/or Nanopore platforms).
If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team.
Please apply directly through LinkedIn.
Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.
Research Associate III/ Senior Research Associate (Biodesigner), Assay Development / Bioanalytical Development
San Francisco, CA job
Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply.
Job Description: Research Associate III/ Senior Research Associate (Biodesigner), Assay Development / Bioanalytical Development
Position Overview: The Research Associate III/ Senior Research Associate in Assay Development and Bioanalytical Development will play a critical role in the development, qualification, and validation of bioanalytical methods to support our RNA editing programs. The successful candidate will work under the guidance of an assay development scientist to develop custom assays for the analysis of samples, including AAVs, cells, and tissues. This role also involves drafting key documents such as Standard Operating Procedures (SOPs) and method development reports.
Key Responsibilities:
Method Development, Qualification, and Validation:
Support the development, qualification, and validation of bioanalytical methods in accordance with regulatory guidelines.
Develop, optimize, and execute robust bioanalytical methods for the characterization, release, and stability testing of Amber's gene therapy.
Sample Analysis:
Support drug absorption, distribution, metabolism, and excretion studies.
Perform analysis of AAVs, cells, and tissues to support various stages of research and development.
Lead efforts to streamline and optimize sample storage and processing, as well as establishing and maintaining critical reagent stocks and cell banks.
Documentation Reporting:
Draft and review key documents such as SOPs, method development, and sample analysis reports.
Maintain accurate and detailed records of all experiments and analyses.
Collaboration & Communication
Collaborate with manufacturing and preclinical teams to support pipeline needs.
Communicate and present findings clearly to internal stakeholders.
Qualifications:
B.A./B.S. or M.S. in Molecular Biology, Biochemistry, Analytical Chemistry, or a related field.
3+ years of experience in bioanalytical and assay development in the biotechnology or pharmaceutical industry.
Demonstrated strong proficiency in a wide range of molecular biology techniques such as molecular cloning, DNA/RNA extractions, RT-qPCR, dd PCR, and ELISA.
Experience with cell-based assays and detection methods such as fluorescence, luminescence, and ECL.
Hands-on experience using laboratory automated systems (e.g., liquid handlers, extraction robotics, etc.).
Background in RNA-based therapies is highly desirable.
Experience writing SOPs and reports supporting IND filings (e.g. development, qualification sample analysis reports, etc.)
Knowledge of FDA and ICH guidelines for method development, qualification, and validation.
Prior history in compiling and analyzing data and generating reports that are routinely presented to project teams.
Ability to work effectively in a collaborative, fast-paced environment.
Preference will be given to those who display:
High motivation, with a strong work ethic and dedication to generating impact.
Attention to detail, with the ability to extract deep insights from data.
Ability to go from ideation to data in an independent fashion.
Long-term personal vision with defined career goals.
Team-oriented thinking.
Demonstrated excellence in small team environments, including a “no task is too small” attitude.
If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team.
Please apply directly through LinkedIn.
Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.
Senior Director, Legal Counsel
San Francisco, CA job
Senior Director, Legal Counsel page is loaded## Senior Director, Legal Counsellocations: South San Francisco, Californiatime type: Full timeposted on: Posted 30+ Days Agojob requisition id: R274Cytokinetics is a late-stage, specialty cardiovascular biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which cardiac muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact myocardial muscle function and contractility.**Responsibilities*** This role is expected to have critical understanding of complex contracts and strong knowledge of key provisions of such agreements such as indemnities, limitations of liability, intellectual property, warranties and covenants, regulatory, termination and other critical contract negotiation issues.* Agreements will include indentures, lease agreements, clinical trial agreements, pharmaceutical license agreements, master service agreements, software license agreements and supply and wholesaler arrangements.* Lead certain general corporate contracts - drafting, negotiating and reviewing certain corporate contracts, as needed and knowledge of contract-related systems.* Independently provide leadership on cross-functional teams, identify legal issues, provide legal options and analysis of possible legal solutions, and give recommendations for addressing critical issues so that business and legal objectives are met.* May also provide support and advice to G&A departments and investor relations.* Manage outside counsel effectively and efficiently, and consistent with applicable budgets. Work creatively with outside counsel to minimize fees and costs.**Qualifications*** JD degree* Admitted to at least one state bar. Admitted to California bar or admitted as Registered In-House Counsel in California is a plus* Minimum of 10 years of experience as in-house counsel in a biotechnology, pharma or healthcare company or a combination of in-house at large public company and/or nationally recognized law firm specializing in the area of interest* Strong working knowledge of U.S. securities laws and NASDAQ requirements. Experience with securities filings of public companies in the life science industry or strong experience in completing public Merger and Acquisition activities* Detailed-oriented with a high level of intellectual, professional and interpersonal agility and flexibility, combined with strong analytical and problem-solving skills* A sophisticated existing understanding of financial regulations* An ability to operate independently* Excellent communication skills, both oral and written* Intellectual curiosity and a willingness to take responsibility for novel and emerging areas of regulation* Well-organized and hardworking, with the ability to manage numerous projects simultaneously under deadline pressure* Excellent analytical skills, with a strong ability to draft and review legal documents, analyze legal advice and apply legal advice to business needs* Ability to form strong working relationships with all levels of management, employees, and partners while maintaining firm adherence to proper legal standards* Team-oriented, sound judgment, self-motivation and willingness to take initiative#LI-HYBRID**Pay Range:**In the U.S., the hiring pay range for fully qualified candidates is $333,000 - $368,000 per year. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.*Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you.***Please review our PRIOR to applying.**Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do - all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process.Here are some ways to check for authenticity:* We do not conduct job interviews through non-standard text messaging applications* We will never request personal information such as banking details until after an official offer has been accepted and verified* We will never request that you purchase equipment or other items when interviewing or hiring* If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at ************************************Please visit our website at:****Cytokinetics is an Equal Opportunity Employer**
#J-18808-Ljbffr
Legal Secretary III
Walnut Creek, CA job
Schmid & Voiles, the dedicated law firm for the Cooperative of American Physicians, Inc. seeks a Legal Secretary to perform diverse secretarial duties in support of the Legal Department, in Walnut Creek. Our dedicated employees are the essential element to CAP's success. CAP's team of well-trained professionals with a commitment to excellence has helped deliver to our member physicians an unparalleled quality of products and services. Our corporate culture and collegial collaboration of minds and efforts is unmatched.
Essential Duties and Responsibilities:
Maintain attorney(s) calendar book and tickler system
Schedule meetings with clients, experts, attorneys and co-counsel and schedule court appearances
Review and re-index mail in OnBase for review and action by attorney and calendaring of same
Compose correspondence and memos to request or provide information
Contact clients to obtain desired information as requested by attorneys
Maintain electronic confidential legal files and ensure that each file is organized and documented regarding activity
Prepare discovery, pre-trial and trial documents for filing with court
Schedule, calendars and coordinate all aspects of discovery initiated by plaintiff(s) and defendant(s)
Provide legal secretarial support on either short- or long-term assignments
Answer and screen telephone calls
Transcribe dictation and/or type from handwritten material or rough draft copy, including correspondence relating to litigation (pleadings, court forms, reports, summaries, releases, etc.
Assist and provide back up for other secretaries
Maintain current knowledge of court rules
Perform additional tasks
Participate in department and company projects
Education and/or Experience:
High school diploma or GED
7 years of defense trial, litigation experience in a similar industry
3 years recent California Civil litigation experience
Trial preparation experience a must
Other Skills and Abilities:
Good organization and communication skills
Thorough knowledge of court procedures
Strong initiative and ability to work independently
Computer literate -proficient in MS Word; knowledge of case management software; type 70+ wpm
Care Coordinator
Pleasanton, CA job
/ RESPONSIBILITIES The Care Coordinator is responsible for coordinating and streamlining the care of patients referred to the Interventional Cardiology Clinic. In this role, you will work closely with multidisciplinary teams, triage referred patients, facilitate timely and appropriate provider scheduling, and ensure continuity of care across outpatient and inpatient settings. The coordinator also serves as a liaison between referring providers, the interventional team, and patients, while supporting program growth through outreach and data management.
EDUCATION/EXPERIENCE
Graduation from an accredited school of nursing with current RN licensure in the State of Texas, BSN preferred. Three years recent, full-time hospital experience preferred. Work experience in cardiovascular or interventional cardiology nursing preferred. Strong knowledge of cardiac procedures, terminology, and clinical workflow. Familiarity with catheterization lab operations, cardiovascular imaging, and post-procedure. Prior experience with patient navigation or care coordination in a cardiology setting preferred. Proficiency in Epic or other major EHR systems preferred.
LICENSURE/CERTIFICATION
Current license from the Board of Nurse Examiners of the State of Texas to practice as a registered nurse is required. National certification in related field is preferred. Case Manager Certification (CCM or ANCC) is highly desirable.
Transition Specialist RN
Pleasanton, CA job
/RESPONSIBILITIES
The Transition Specialist, RN, contributes to the Long Term Services and Supports (LTSS) service coordination process by performing activities within the scope of licensure; provides supervision and direction to staff participating in Member's cases following applicable state law and contract; develops, monitors, evaluates, and revises the Members' care plans to meet Member's needs, to optimize health care across the care continuum to enhance the Member's well-being, independence, integration in the community, and potential for productivity. The Transition Specialist, RN, conducts a holistic assessment of the Member's dynamics, needs, and preferences while providing education and health-related information to the Member, the Member's Legal Authorized Representative (LAR), and the Member's Support Network. Responsible for the coordination of STAR+PLUS Members' covered and non-capitated services, including acute and LTSS, while meeting the Member's physical, behavioral, functional, and psychosocial needs. Complies with policies, procedures, and protocols for establishing and maintaining good working relationships with co-workers, employees, patients, and guests
EDUCATION/EXPERIENCE
Graduation from an accredited school of professional nursing or social work is required. BSN is required . Four (4) recent years of clinical experience preferred, which may include service coordination, case management, quality management, or managed care experience. Working knowledge of HMO standards, LTSS, and NCQA standards is preferred. Knowledge of Medicare and Medicaid HMO experience is preferred. Experience in meeting the needs of vulnerable populations who have chronic, complex conditions, with serious and persistent mental illness (SPMI), lived experience of mental illness or both, and helping people transition from institutional settings to the community is preferred. Individuals selected for these positions must complete training specified by HHSC and demonstrate knowledge and skills delivering the Transition Specialist pilot interventions. Bilingual, English/Spanish, is preferred
LICENSURE/ CERTIFICATION
A current, unrestricted license to practice professional nursing issued by the State of Texas is required. RUG Certification is required and must be obtained within 30 days of employment for all RN candidates
Staff Accountant
Newark, CA job
Ardelyx is a publicly traded commercial biopharmaceutical company founded with a mission to discover, develop and commercialize innovative first-in-class medicines that meet significant unmet medical needs. Ardelyx has two commercial products approved in the United States, IBSRELA (tenapanor) and XPHOZAH (tenapanor). Ardelyx has agreements for the development and commercialization of tenapanor outside of the U.S. Kyowa Kirin commercializes PHOZEVEL (tenapanor) for hyperphosphatemia in Japan. A New Drug Application for tenapanor for hyperphosphatemia has been approved in China with Fosun Pharma. Knight Therapeutics commercializes IBSRELA in Canada.
Position Summary:
For this Staff Accountant role, we are seeking an individual candidate who will contribute to the general ledger accounting functions/processes, including accruals for outside service providers, cash and investments, fixed assets, various prepaids and other account reconciliations. The individual will also contribute to various month-end and quarter-end internal reporting tasks, as well as assist with external auditor requests. They will be responsible for complying with all internal controls they are responsible for, including but not limited to gathering evidence support related to IT general controls, specifically as the relate to financial reporting. The Staff Accountant will work closely with the Senior Accountant and Senior Accounting Manager and will assist in identifying and establishing processes or process improvements as the company continues to grow and evolve.
Responsibilities:
* Prepare accurate journal entries and timely general-ledger account reconciliations for various account types (including cash & investments, prepaids, other assets, and liabilities); responsibilities may evolve as the company grows
* Review and post month-end close accounting transactions with precision and efficiency
* Participate in the performance monthly close process and preparation of monthly financial reporting and rollforward packages for management review
* Perform balance sheet and P&L account analyses, reviews, reconciliations and resolutions of variances
* Consistently maintain robust internal controls and uphold company policies & procedures
* Collaborate with non-finance internal departments to determine the financial impact of major contracts and project statuses, supporting the accrual process
* Collaborate effectively with external auditors during interim and year-end audits by delivering timely, accurate data and communication
* Contribute to the external financial-reporting process, including quarterly and annual filings (Forms 10-Q and 10-K), and other required SEC disclosures
* Prepare supporting schedules and documentation for SEC filings in a structured and audit-ready manner
* Assist with control updates, including identifying gaps and aiding in process redesign to strengthen the control environment
* Perform ad-hoc accounting analyses, schedules and reconciliations as requested by management or other stakeholders
Qualifications:
* Bachelor's degree in accounting or related discipline (CPA or equivalent is a plus) with 1 - 4 years of related accounting and finance experience or equivalent experience
* Experience preparing financial statements
* Experience with ERP systems (NetSuite is a plus)
* Demonstrated strong Excel and analytical skills
* Familiarity with SOX compliance and internal controls
* Strong attention to detail with exceptional organization and problem-solving abilities
* Demonstrated strong learning agility and excels in fast-moving environments
* Ability to embrace innovation and change, continuously exploring new ideas and proactively shaping process improvements
* Cultivate collaborative relationships across departments, establishing rapport quickly and maintaining professional stability
* Demonstrate exceptional communication skills, effectively articulating complex ideas to diverse audiences
* Thrive in team environments while respectfully voicing alternative viewpoints and contributing constructively to group decision-making
* Operate independently with minimal oversight, consistently adapting to evolving priorities and embracing progressive change
The anticipated annualized base pay range for this full-time position is $76,000 - $92,000. Ardelyx utilizes industry data to ensure that our compensation is competitive and aligned with our industry peers. Actual base pay will be determined based on a variety of factors, including years of relevant experience, training, qualifications, and internal equity. The compensation package may also include an annual bonus target and equity awards, subject to eligibility and other requirements.
Ardelyx also offers a robust benefits package to employees, including a 401(k) plan with generous employer match, 12 weeks of paid parental leave, up to 12 weeks of living organ and bone marrow leave, equity incentive plans, health plans (medical, prescription drug, dental, and vision), life insurance and disability, flexible time off, annual Winter Holiday shut down, and at least 11 paid holidays.
Ardelyx is an equal opportunity employer.
Auto-ApplySenior Manager, Data Management
Newark, CA job
Ardelyx is a publicly traded commercial biopharmaceutical company founded with a mission to discover, develop and commercialize innovative first-in-class medicines that meet significant unmet medical needs. Ardelyx has two commercial products approved in the United States, IBSRELA (tenapanor) and XPHOZAH (tenapanor). Ardelyx has agreements for the development and commercialization of tenapanor outside of the U.S. Kyowa Kirin commercializes PHOZEVEL (tenapanor) for hyperphosphatemia in Japan. A New Drug Application for tenapanor for hyperphosphatemia has been approved in China with Fosun Pharma. Knight Therapeutics commercializes IBSRELA in Canada.
Position Summary:
The Senior Manager, Data Management serves as the Lead DM and oversees day-to-day DM support from direct reports and external vendors, including Contract Research Organizations (CROs) and contractors, for Ardelyx's clinical studies across multiple therapeutic areas. This role works closely with the Head of Biometrics, Biostatistics, Statistical Programming, Clinical Operations, Clinical Safety, and Medical to ensure high-quality, reliable, and compliant clinical data. As the DM Group Lead within Biometrics, the Sr. Manager of DM also develops, implements, and maintains standard operating procedures (SOPs) and work instructions that govern DM activities at Ardelyx.
Responsibilities:
* Serve as the in-house Lead Data Manager for Ardelyx clinical studies across multiple therapeutic areas
* Design electronic Case Report Forms (eCRFs) and perform hands-on creation and configuration of eCRFs within the Electronic Data Capture (EDC) system
* Develop, update, and maintain study-specific DM documentation, including Data Management Plans (DMPs), eCRF Completion Guidelines (eCCG), and Edit Check Specifications
* Perform and coordinate User Acceptance Testing (UAT) for the EDC system
* Generate, process, track, and resolve data queries in a timely manner and perform data reconciliation across multiple clinical data sources (e.g., EDC, ePRO, IRT, central lab, safety database)
* Perform database freeze and lock activities, and manage database unlocks as required.
* Oversee medical coding activities using standardized dictionaries (MedDRA, WHODrug), whether conducted internally or by external vendors, ensuring accuracy and compliance
* Lead the implementation and maintenance of CDASH-based data collection standards to ensure consistency and facilitate development of SDTM domains
* Participate in clinical trial budget planning and vendor selection
* Manage the DM group and leverage resources for all DM deliverables
* Oversee DM activities conducted by external vendors, ensuring adherence to timelines, quality standards, and contractual obligations
* Develop, implement, and maintain SOPs and work instructions that govern DM activities at Ardelyx
Qualifications:
* Bachelor's degree, advanced degree preferred, in a biomedical science or related field with 8 - 10 years of related experience in a pharmaceutical, biotech, or CRO setting, or equivalent experience
* Strong knowledge of ICH, FDA, GCP, and HIPAA regulations and guidelines; familiarity with EDC systems (e.g., Medidata RAVE) and industry-standard coding dictionaries (MedDRA and WHODrug)
* Proficient in all aspects of DM from study start-up through study close-out, including eCRF design, development of DM documentation (e.g., DMP and eCCG), data validation, discrepancy management, data reconciliation, external data transfers, and database freeze/lock/unlock procedures
* Knowledge of CDASH standards and their application to eCRF design and data collection
* Programming experience with SQL or SAS (preferred, but not required)
* Experience managing DM support from external vendors, particularly CROs
* Ability to work both independently and collaboratively in a cross-functional team environment
* Strong organizational and problem-solving skills with great attention to detail and the ability to manage multiple priorities
* Strong verbal and written communication skills
The anticipated annualized base pay range for this full-time position is $173,000-$211,000. Ardelyx utilizes industry data to ensure that our compensation is competitive and aligned with our industry peers. Actual base pay will be determined based on a variety of factors, including years of relevant experience, training, qualifications, and internal equity. The compensation package may also include an annual bonus target and equity awards, subject to eligibility and other requirements.
Ardelyx also offers a robust benefits package to employees, including a 401(k) plan with generous employer match, 12 weeks of paid parental leave, up to 12 weeks of living organ and bone marrow leave, equity incentive plans, health plans (medical, prescription drug, dental, and vision), life insurance and disability, flexible time off, annual Winter Holiday shut down, and at least 11 paid holidays.
Ardelyx is an equal opportunity employer.
Auto-ApplyAssociate Director, Nonclinical Development
Newark, CA job
Ardelyx is a publicly traded commercial biopharmaceutical company founded with a mission to discover, develop and commercialize innovative first-in-class medicines that meet significant unmet medical needs. Ardelyx has two commercial products approved in the United States, IBSRELA (tenapanor) and XPHOZAH (tenapanor). Ardelyx has agreements for the development and commercialization of tenapanor outside of the U.S. Kyowa Kirin commercializes PHOZEVEL (tenapanor) for hyperphosphatemia in Japan. A New Drug Application for tenapanor for hyperphosphatemia has been approved in China with Fosun Pharma. Knight Therapeutics commercializes IBSRELA in Canada.
Position Summary:
We are seeking an Associate Director of Nonclinical Development to join our experienced R&D team supporting drug development programs. The Associate Director will design and implement nonclinical strategies to evaluate and advance Ardelyx's drug candidates through different stages of development. This position involves designing and managing GLP safety studies at contract research organizations (CROs) for early and late-stage programs, analyzing and interpreting safety data, and collaborating with cross-functional teams.
Responsibilities:
* Oversee the conduct of nonclinical studies to support Ardelyx programs, including non-GLP and GLP toxicology, pharmacology, and DMPK studies
* Identify/qualify new or existing CROs
* Serve as the Nonclinical representative during GLP audits
* Author and review SOPs and policies related to the Nonclinical function
* Oversee study logistics, including managing contracts with vendors, tracking invoices and payments, and procuring/shipping study materials
* Conduct study monitoring visits
* Review and evaluate study protocols, data, and reports
* Author and review regulatory documents including IND, NDA/BLA, IB, and DSUR
* Prepare and present study updates to internal project teams and senior management
Qualifications:
* PhD or advanced degree in toxicology, pharmacology, biology, or related scientific discipline with 7+ years of relevant work experience in the pharmaceutical industry or equivalent experience
* In-depth knowledge and technical oversight of nonclinical toxicology, pharmacology, and DMPK studies
* Experience conducting or overseeing nonclinical studies with small and large molecules is preferred
* Extensive knowledge of GLP principles and FDA/ICH guidelines
* Ability to analyze/interpret complex data and troubleshoot
* Highly organized with excellent written and oral communication skills
* Experience as a supervisor is a plus
* Ability to work effectively with cross-functional R&D colleagues
The anticipated annualized base pay range for this full-time position is $205,000 - $251,000. Ardelyx utilizes industry data to ensure that our compensation is competitive and aligned with our industry peers. Actual base pay will be determined based on a variety of factors, including years of relevant experience, training, qualifications, and internal equity. The compensation package may also include an annual bonus target and equity awards, subject to eligibility and other requirements.
Ardelyx also offers a robust benefits package to employees, including a 401(k) plan with generous employer match, 12 weeks of paid parental leave, up to 12 weeks of living organ and bone marrow leave, equity incentive plans, health plans (medical, prescription drug, dental, and vision), life insurance and disability, flexible time off, annual Winter Holiday shut down, and at least 11 paid holidays.
Ardelyx is an equal opportunity employer.
Auto-ApplyNurse Case Manager - UMA Nephrology
Pleasanton, CA job
/RESPONSIBILITIES
Coordinates the education and plan of care for patients recently diagnosed with ESRD from UH inpatient and/or Renal Clinics. Facilitates the delivery of services, evaluates effectiveness, tracks outcomes and functions as the patient advocate to identify and communicate health care needs related to vascular access and renal needs. Supports and adheres to University Health and department specific policies and standards. Mentors and serves as a clinical role for all staff. Receives mentoring from Executive Director of Dialysis Services
EDUCATION/EXPERIENCE
BSN is highly preferred. Must meet career ladder Staff Nurse II criteria for worked area. Two years or more of nursing experience required
LICENSURE/ CERTIFICATIONS
Current licensure as a Registered Nurse with the Texas State Board of Nurse Examiners is required. Current American Heart Association, Basic Cardiac Life Support and Healthcare Provider card
High-Throughput Screening Research Associate II, III (Biodesigner II, III)
San Jose, CA job
Amber Bio is a biotechnology company pioneering new gene editing modalities using multi-kilobase edits to reach previously undruggable patient populations. Founded by pioneers in the CRISPR field from leading institutions for gene editing research, the company is developing a first-of-its-kind RNA editing platform that can correct thousands of bases at once, thereby correcting genetic mutations safely and reversibly. If you are interested in building a new frontier in genetic medicine, we welcome you to apply.
Job Description: High-Throughput Screening Research Associate II, III (Biodesigner II, III)
Responsibilities:
Perform massively parallel reporter assays and high-throughput screens across diverse cellular contexts using cellular and molecular readouts.
Develop and execute molecular biology workflows such as vector design and cloning, DNA/RNA extraction, RT-PCR, qPCR, and next-generation sequencing.
Support cell culture activities and experiments in multiple cell lines, at small and large scales.
Design and execute cell-based assays (AAV/lentiviral transduction, transfection, flow cytometry, immunostaining, and other plate reader assays).
Engineer and characterize cell-based systems using synthetic biology tools and techniques.
Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to optimize screening throughput, sensitivity, and specificity.
Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches.
Prepare summaries of data and present internally to colleagues and management.
Draft SOPs, follow protocols, diligently document experimental data in lab notebooks, and organize and maintain electronic work records.
Author scientific reports and data summaries.
Collaborate with cross-functional teams to meet project goals, bridging early discovery with high-throughput screens to nominate and optimize candidates for further characterization.
Qualifications:
Bachelor's or Master's degree in Biology, Biochemistry, Chemical Engineering, Biological Engineering, or a related field.
At least 2 years of industry wet lab experience.
Mammalian cell culture experience (culturing, transfecting and transducing cells, and DNA/RNA purification from cells).
Molecular biology expertise (vector design and cloning, qPCR, primer and probe design, DNA/RNA extraction workflows)
Critical thinker with excellent communication skills who thrives in a multidisciplinary, fast-paced team environment.
Strong written and verbal communication skills.
Preference will be given to those who display:
High throughput screening assay development in an industry setting.
High motivation, with a strong work ethic and dedication to generating impact.
Attention to detail, with the ability to extract deep insights from data.
First-principles thinking, and an ability to refine one's intuition based on additional data.
Ability to go from ideation to data in an independent fashion.
Long-term personal vision with defined career goals.
High EQ with team-oriented thinking.
Experience with pooled, high-throughput screens using next-generation sequencing-based readouts, and/or preparing screening plasmid libraries from synthesized oligo arrays.
Experience with CRISPR-Cas systems and/or gene editing and delivery technologies.
Experience preparing next-generation sequencing libraries (Illumina, PacBio, and/or Nanopore platforms).
If you have a passion for advancing gene editing technologies and desire to be part of a pioneering biotech company, we encourage you to apply and join our ambitious team.
Please apply directly through LinkedIn.
Amber Bio is an equal-opportunity employer and encourages applications from candidates of diverse backgrounds. We value diversity and are committed to creating an inclusive and supportive work environment for all employees.