Research Fellow jobs at Dana-Farber Cancer Institute

The laboratory of Zuzana Tothova, MD, PhD is a multi-disciplinary team of physician scientists, scientists and computational biologists at the Dana-Farber Cancer Institute and the Broad Institute. Our laboratory uses genomics and a range of molecular and cellular biological techniques to elucidate the molecular basis of cancer and hematologic disorders and to develop novel therapeutics. Our specific focus is to understand the role of chromatin modifiers and epigenetic factors and find novel therapeutic opportunities in myeloid malignancies, including myelodysplastic syndromes and acute myeloid leukemia. JOB TITLE: Associate computational biologist FLSA: Full-time, on-site REPORTS TO: Zuzana Tothova, M.D., Ph.D. DEPT: Medicine Oncology/ Heme Neoplasia **General Summary** A full-time associate computational biologist position is available in the laboratory of Zuzana Tothova, M.D., Ph.D. at Dana-Farber Cancer Institute. We are seeking enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging research environment, and can interact well with others as part of a cohesive team. If you have a desire to make a significant impact in healthcare and have the fortitude to work hard, you will succeed within this team. This is an ideal entry-level or mid-level position into the world of cutting-edge laboratory research. A growth mindset and a willingness to take on challenging learning opportunities will be sought out traits. Ideal candidates will possess strong interpersonal skills along with a desire to help others to succeed. Previous team members have gone on to successful academic and career opportunities; graduate/medical school and industry. The candidate will be involved in a series of research activities, including computational analysis of large-scale data sets generated in in vitro and in vivo human disease relevant models and use of next generation sequencing with a special emphasis on understanding the biology of human myeloid malignancies. The Associate Computational Biologist is training to become a Computational Biologist. They are responsible for routine data analysis or processing of biological data, with a focus on high-throughput technologies and genomic databases, under the supervision of mentor. The Computational Biologist is a quantitative scientist who collaborates with scientific investigators and with other research staff in the analysis of high-throughput data, and dissemination of scientific results. The Computational Biologist may work on many types of projects and areas of research including cancer genomics, functional genomics, immuno-oncology, molecular imaging, data management and integration, and querying biological databases. **We are looking for candidates with at least 2 years of availability.** Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. **PRIMARY DUTIES AND RESPONSIBILITIES:** 1. Data Processing Builds data processing pipelines to convert raw data into formats compatible with conventional statistical analysis and visualization under supervision of mentor. 2. Data Analysis: Follows a detailed manual to perform routine. 3. Data and Software Management: Monitors, downloads, organizes, and manages data from public data repositories or generated by collaborates. 4. Manuscript Preparation: Helps prepare tables and figures. 5. Research Portfolio Management: Trains to develops timelines and components for multiple routine projects; masters multi-tasking so that complex projects involving many interdisciplinary individuals move forward smoothly. 6. Works closely with postdoctoral fellows and graduate students in the lab and computational biology collaborators at the Dana-Farber Cancer Institute and the Broad Institute to analyze biological data sets, including but not limited to DNA and RNA sequencing, gene expression and transcriptome analysis, chromatin landscape profiling, and analysis of microscopy/imaging data. 7. Modifies and maintains existing data-processing pipelines in the lab, and develops new pipelines and tools to analyze novel forms of data, including data cleaning, normalization, and visualization. 8. Integrates multiple data sets to answer targeted scientific questions. 9. Documents and compiles findings in oral and written reports. 10. Attends team meetings to share results, plan projects and experiments. 11. Maintains and improves technical knowledge base. 12. Other related tasks as required. **KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:** + Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. + Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. + Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. **MINIMUM JOB QUALIFICATIONS:** Minimum Education: Bachelor's degree in a computer science or related-STEM field required. Minimum Experience: No prior experience required. **KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:** + Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. + Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. + Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. + Strong interpersonal skills - ability to effectively interact with all levels of staff and external contacts. + Excellent analytical, organizational and time management skills. + Familiarity with bioinformatics data types and software preferred + Familiarity with GitHub and HPC preferred + Passion for science and strong motivation required. + Must be a strong team player. + Strong interpersonal, communication and organizational skills, including the ability to handle a variety of tasks in a fast-paced environment, positive attitude and attention to detail, as well as ability to think on one's feet are required. + Must possess a high level of initiative, curiosity and dedication, proactivity in identifying problems and solutions to address them. + Familiarity with bioinformatics data types (e.g. FastQ, BAM, BigWig) and software (e.g. DeepTools, MACS, HOMER) preferred. + Familiarity working with Git repositories preferred. + Familiarity with computational methods for single-cell sequencing data preferred. **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $60,000 - $67,466 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary A postdoctoral research fellow position is available at Brigham and Women's Hospital/ Harvard Medical School, Boston. The laboratory's research is interested in understanding the role of non-coding RNAs (mi RNAs/lnc RNAs) and their signaling pathways/targets in a range of vascular disease states including atherosclerosis and ischemic injury in the heart and limb with a major focus in diabetes. The specific projects deal with understanding the mechanisms and functions of identified non-coding RNAs in cell types important to cardiovascular disease and diabetes such as endothelial cells, vascular smooth muscle cells, and leukocyte subsets. Studies will involve understanding specific aspects of non-coding RNAs and target gene function in vitro and in vivo using mouse knockout, knockdown, or overexpression studies, and translational assessment in human specimens. Qualifications Candidate must have a strong background in molecular and cellular biology, or vascular biology, outstanding written and verbal communication skills, be self-motivated, have demonstrated productivity, and ability to be independent while also working in a team environment. Experience in molecular biology and mice is strongly preferred. Candidates must be able to make a 2-year commitment. Degree Required: Ph.D. or M.D. Interested candidates are asked to send curriculum vitae and name/contact information of 3 references to: Mark Feinberg, MD, Professor of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115; EMAIL to: ************************* Additional Job Details (if applicable) Remote Type Onsite Work Location 77 Avenue Louis Pasteur EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts Eye and Ear Infirmary Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Summary Proposes and undertakes a mentored, innovative project or challenge to develop novel molecular therapies for inherited retinal degenerative diseases (IRD's). Involves in the study of host-AAV interactions, retinal tropism, and development of enabling gene therapy technologies, with a potential for translation of preclinical therapeutic gene transfer programs. Perform in vivo experiments involving the characterization of retinal phenotypic defects in mouse models of IRD's. Designs and performs in vitro and animal experiments, analyzes, and presents the outcome. Qualifications ESSENTIAL FUNCTIONS: * Read, analyze, and summarize published literature * Design and execute in vitro and in vivo. * Undertake relevant coursework if required by mentor. * Attend relevant meetings. * Meet regularly with the mentor to review project progress and milestones * Plan and deliver a seminar on the project * Take administrative (inventory, purchasing, etc. ) responsibilities in the lab when necessary * Write a final report or submit a manuscript to a peer-reviewed journal describing the project and results EDUCATION AND EXPERIENCE: Doctoral degree (MD or PhD) with more than 1 year of lab experience. WORKING CONDITIONS: Lab setting. PHYSICAL REQUIREMENTS: Possible lifting of 10 to 20 lbs., depending on nature of chosen project(s). HIPAA Privacy Training and Sanctions All employees who have access to health information whose confidentiality is protected by the HIPAA Privacy Rule are required by the Rule to receive training so that they have an understanding and knowledge of the Privacy Rule that corresponds to their job responsibilities and of the group health plan's policies and procedures that impact on their job duties. Training on the requirements of the HIPAA Privacy Rule and the plan's health information policies and procedures under the direction of the institution's privacy officer is a pre-requisite for this position. Employees who violate the requirements of the HIPAA Privacy Rule will be subject to discipline, up to and including termination. This description is intended to indicate essential tasks and levels of work difficulty that will be required of positions that will be given this title. It is not intended to limit or in any way modify the right of supervisors to assign, direct, or control the work of staff members under their supervision. The use of a particular expression or illustration describing duties shall not be held to exclude other duties not mentioned but that are of similar kind or level of difficulty. Additional Job Details (if applicable) Remote Type Onsite Work Location 20 Staniford Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary HOW TO APPLY: To apply, please submit your CV and a letter of interest to mgh_****************** The Massachusetts General Hospital (MGH) Center of Excellence (COE) for Psychosocial and Systemic Research, in partnership with the MGH Department of Psychiatry, Harvard Medical School (HMS), and the Massachusetts Department of Mental Health, is recruiting two full-time, one-year postdoctoral fellows. We seek to recruit trainees who have an interest in pursuing a clinical career in public or community mental health treatment settings, implementing evidence-based practices in these settings, and optimizing systems of care to promote health equity. Each one-year, full-time clinical post-doctoral psychology position provides focused training experiences in evidence-based psychosocial treatments and rehabilitation approaches for serious mental illness (SMI) and is designed to help trainees develop an understanding of, and facility with, assisting patients and families to navigate the public and community system of psychiatric care in Massachusetts. Inpatient and outpatient settings comprise the training experience and although there is a focus on SMI, trainees also have the opportunity to gain experience with a broad range of psychological presentations in an outpatient community behavioral health setting. Experiences are designed to provide trainees with an understanding of best practices in psychotherapy and psychiatric rehabilitation for individuals with SMI as well as underserved and vulnerable populations treated in public and community settings who may experience a range of adverse social determinants of health, including poverty, immigration challenges, homelessness, and trauma. Training experiences can be tailored to the interests of the trainee. While the fellowship has a primary clinical training focus, research opportunities are available through the COE. The selected candidate will join a vibrant clinical and research community at MGH, located in Boston's West End. He/She/They will be recommended for an academic appointment as a clinical fellow at HMS and will have access to MGH's employee benefits plan. Qualifications HOW TO APPLY: To apply, please submit your CV and a letter of interest to mgh_****************** Key responsibilities include: * Experience working as part of an interdisciplinary early intervention service for first episode psychosis; training opportunities with individuals with longer histories of SMI as well as those identified as being at clinical high-risk are also available (see ***************************************************** * Inpatient experience in a DMH-facility serving eligible individuals with SMI as well as a forensic population * Training experiences in providing outpatient care for a broad range of psychological disorders at one of the MGH Community Health Centers Qualifications: * PhD in clinical psychology, counseling psychology, or a related field * At least 3 years of clinical experience, inclusive of experience acquired during doctoral training Additional desirable experiences and skills: * Fluency in another language, preferably Spanish * Clinical training and experience working with child and adolescent populations * Clinical training and experience with evidence-based treatments for trauma and/or trauma-informed care * Clinical license eligibility upon completion of a one-year post-doctoral fellowship * Interest or experience in community-based participatory engagement/research or lived experience engagement/research As an equal opportunity and affirmative action employer, we recognizes the power of a diverse community and encourages applications from individuals with varied experiences, perspectives, and backgrounds. Additional Job Details (if applicable) Remote Type Hybrid Work Location 15 Parkman Street EEO Statement: Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts Eye and Ear Infirmary Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Summary Will conduct independent and collaborative research, contributing to the advancement of knowledge and the development of innovative solutions. The fellow will work under the supervision of the Principal Investigator and collaborate with a team of researchers. Does this position require Patient Care? No Essential Functions * Design, plan, and execute research experiments or projects in alignment with departmental goals. * Gather, analyze, and interpret data using appropriate statistical methods and tools. * Conduct comprehensive literature reviews to inform research direction and methodologies. * Prepare and publish research findings in peer-reviewed journals and present at conferences and seminars. * Work collaboratively with faculty, students, and other researchers, contributing to a positive research environment. * Mentor graduate and undergraduate students, providing guidance on research methodologies and techniques. * Assist in the preparation of grant proposals and funding applications to support ongoing research. * Prepare periodic reports and documents summarizing research progress and outcomes. Qualifications Education Doctorate Related Field of Study required Can this role accept experience in lieu of a degree? No Licenses and Credentials Experience Previous Research experience 3-5 years preferred Knowledge, Skills and Abilities * Demonstrated experience in research techniques, methods, or research areas relevant to the project. * Proficient analytical skills, proficiency in statistical software, and excellent written and verbal communication skills. * Ability to work independently as well as collaboratively within a team. * Good interpersonal and communication skills. Additional Job Details (if applicable) The Shalhout Lab is recruiting a highly motivated postdoctoral fellow with expertise in small molecule drug discovery, molecular biology, biochemistry, and/or chemistry. Our group is developing innovative approaches to treat cancers by combining cutting-edge experimental biology with computational biology. We are seeking candidates with strong wet-lab skills who are excited to design, execute, and interpret experiments that drive therapeutic discovery. ESSENTIAL FUNCTIONS: * Design and perform biophysical and biochemical assays, including protein purification, binding/interaction studies, cell reporter assays, and enzymatic assays. Purify and characterize proteins for structural and functional studies. * Design and perform protein-protein and protein-ligand interactions (e.g., SPR, ITC, pull-downs, FRET). * Conduct cell-based functional assays such as reporter assays, qPCR, and molecular characterization of signaling pathways. * Carry out molecular biology techniques, including cloning, mutagenesis, and protein expression. Perform mutagenesis and structure-function studies to map binding sites and mechanisms of action. * Support hit validation and lead optimization through iterative testing of small molecules. * Collaborate with medicinal chemistry and computational teams to prioritize candidates and refine drug design. * Basic understanding of biostatistics * Analyze and interpret experimental data, present findings in lab meetings, publications, and conferences. * Collaborate with team members on projects linking experimental data to translational cancer research EDUCATION AND EXPERIENCE: PhD in a relevant field (Molecular Biology, Biochemistry, Biophysics, Cancer Biology, or related discipline) with a strong track record of peer-reviewed publications in areas such as drug discovery, small-molecule therapeutics, or translational oncology research. WORKING CONDITIONS: Dry and potentially wet lab setting. Remote Type Onsite Work Location 20 Staniford Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. The Research Fellow will play a crucial role in the MGH Cardiovascular Research Center's Wyant Lab. The scientific mission of the Wyant Lab is to understand the mechanism by which key physiological inputs, such as oxygen, nutrients, mechanical stretch, and electrical signals regulate heart, muscle, and brain function. The goal is to ultimately identify novel therapeutic strategies for heart failure, neurodegeneration, or muscle atrophy. We are particularly interested in candidates with prior experience in Crispr-Cas9 genetic screening technologies, protein purification and structural biology, and mouse physiology. Qualified candidates with a PhD should send their CV and a cover letter to Dr. Gregory Wyant at **********************. Job Summary Summary Does this position require Patient Care? No Essential Functions Qualifications Education: PHD Can this role accept experience in lieu of a degree? No Licenses and Credentials Experience Knowledge, Skills and Abilities Additional Job Details (if applicable) Physical Requirements * Standing N/A = (0%) * Walking N/A = (0%) * Sitting N/A = (0%) * Lifting N/A = (0%) * Carrying N/A = (0%) * Pushing N/A = (0%) * Pulling N/A = (0%) * Climbing N/A = (0%) * Balancing N/A = (0%) * Stooping N/A = (0%) * Kneeling N/A = (0%) * Crouching N/A = (0%) * Crawling N/A = (0%) * Reaching N/A = (0%) * Gross Manipulation (Handling) N/A = (0%) * Fine Manipulation (Fingering) N/A = (0%) * Feeling N/A = (0%) * Foot Use N/A = (0%) * Vision - Far N/A = (0%) * Vision - Near N/A = (0%) * Talking N/A = (0%) * Hearing N/A = (0%) Remote Type Onsite Work Location 149 Thirteenth Street Building 149 Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Courtesy posting Job Summary This job involves working independently and under general supervision from the Principal Investigator on NIH-sponsored research. The primary goals of the Post Doctoral Fellow will be to lead the network data analysis in relation to cutting-edge research in neurology and network science. The Post-Doctoral Fellow will supervise and assist with this federally funded clinical studies which aim to investigate the relationships between patient's social networks and their clinical outcomes. Qualifications Primary responsibilities will include data analysis, academic writing, contributing to the overall research effort at the Dhand Lab, grant writing, attending conferences, participating in meetings with collaborators , and any other related duties assigned to the fellow by the PI . This position will provide the Post-Doctoral Fellow the opportunity to gain leadership skills and data analysis skills that could lead to academic presentations or publication opportunities. This job is well-suited for individuals interested in social networks, neurology, population health, and a career in academic research or data analysis. A background in either population health, epidemiology, biostatistics, computer science, or social science are beneficial. Interested applicants can learn more about the research team and its work by visiting ***************** PRINCIPAL DUTIES AND RESPONSIBILITIES: 1. Lead writing of academic articles. 2. Conduct data analysis for clinical research studies as per study guidelines and protocols. 3. Responsible for maintaining database for study. May be required to monitor data quality, maintain data analysis records, and create data reports. 4. Code and completes analyses related to project in the R environment and other software platforms. 5. Strong interest in contributing to the overall scientific literature especially in interdisciplinary research with journals in neurology, neuroscience, social network sciences, network science, and population health. 6. Attend required meetings with PI and collaborators. 7. All other duties, as assigned. QUALIFICATIONS: Doctoral Degree in either epidemiology, biostatistics, population health, social sciences, physics, or related fields. Sound independent judgment, knowledge and experience in data analysis and competence in research methodologies. SKILLS/ ABILITIES/ COMPETENCIES REQUIRED: 1. Ability to work independently. 2. Good oral and written communication skills. 3. Analytical skills and the ability to resolve technical or research problems and issues and to interpret the acceptability of data results. 4. Knowledge of clinical research protocols. 5. High degree of data analysis. 6. Excellent organizational skills and ability to prioritize a variety of tasks. 7. Careful attention to detail. 8. Ability to demonstrate professionalism and respect for subjects' rights and individual needs. 9. Knowledge of data management programs. 10. Experience in scientific writing. If interested in applying, please submit CV and Cover Letter to CVs: Vrushali Dhongade (*************************) and Dr. Amar Dhand (**********************). Additional Job Details (if applicable) Default Add'l Job Description Remote Type Hybrid Work Location 75 Francis Street EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts Eye and Ear Infirmary Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary We have an open position for a computer science/machine-learning postdoctoral fellow to work on machine-learning algorithms for automatic diagnosis of dystonia, prediction of the risk for dystonia development, and the efficacy of treatment outcomes. This work will be directly related to the extension of our recently developed DystoniaNet platform and will include brain MRI datasets from patients with dystonia, other movement disorders, and healthy individuals. The postdoctoral fellow will be part of a multidisciplinary team of neuroscientists, neurologists, laryngologists, and geneticists at Mass Eye and Ear and Mass General Hospital and work at the intersection on the development, testing and implement of DystoniaNet in the clinical setting. This position is best suited for an individual with a broad computer science background interested in understanding and examining critical clinical problems and developing research solutions for their translation to healthcare. The fellow will be highly competitive to pursue future opportunities in either academia or industry (pharma and biotech). Qualifications Postdoctoral Fellow in Deep Learning We have an open position for a computer science/machine-learning postdoctoral fellow to work on machine-learning algorithms for automatic diagnosis of dystonia, prediction of the risk for dystonia development, and the efficacy of treatment outcomes. This work will be directly related to the extension of our recently developed DystoniaNet platform and will include brain MRI datasets from patients with dystonia, other movement disorders, and healthy individuals. The postdoctoral fellow will be part of a multidisciplinary team of neuroscientists, neurologists, laryngologists, and geneticists at Mass Eye and Ear and Mass General Hospital and work at the intersection on the development, testing and implement of DystoniaNet in the clinical setting. This position is best suited for an individual with a broad computer science background interested in understanding and examining critical clinical problems and developing research solutions for their translation to healthcare. The fellow will be highly competitive to pursue future opportunities in either academia or industry (pharma and biotech). Responsibilities include but may not be limited to * Experimental data collection and processing * Development and refinement of deep learning and other benchmark algorithms for predictive classification of dystonia and other related disorders * Clinical translation and implementation of the developed algorithms and interactions with clinicians for their testing * Establishment of new and fostering of existing collaborations * Participation in the regulatory aspects of clinical translation and patenting * Presentation of the results at the scientific meetings and publication of journal articles * Mentoring junior staff Qualifications and Skills * PhD or an equivalent degree in computer science, neuroscience, biomedical engineering, or related fields * Broad proficiency and experience with supervised and unsupervised machine-learning methods, expertise in building neural network architectures * Experience with neuroimaging data processing * Advanced programming skills (Python and/or Matlab), including deep learning packages (e.g., TensorFlow or Keras) * Knowledge and experience with cloud-based computational platforms (e.g., AWS) * Excellent verbal and written communication skills * Strong publication record and academic credentials * Ability to work effectively both independently and in collaboration with multiple investigators Additional Job Details (if applicable) Remote Type Onsite Work Location 243-245 Charles Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts Eye and Ear Infirmary Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Postdoctoral Fellow in ECoG/LFP of Speech Control An NIH-funded postdoctoral fellow position is available to study speech control in patients with dystonia and tremor using a combination of electrocorticography/local field potential (ECoG/LFP), electroencephalography (EEG), structural (MRI, DWI) and functional (fMRI, EEG) neuroimaging, and clinical-behavioral neurotesting. The postdoctoral fellows will function as part of a multi-disciplinary team of neuroscientists and clinicians. Responsibilities include participating in all aspects of data acquisition and management; developing, modifying, and executing analytical protocols; preparing publications and scientific presentations; disseminating results in peer-reviewed scientific journals and at major national and international meetings, and mentoring junior staff. Opportunities exist for excellent scientific interactions and collaborations with an extensive program of seminars, symposia, and other meetings focused on a large array of topics in neuroscience, neurosurgery, clinical research, and neurotechnology. Qualifications Education Can this role accept experience in lieu of a degree? Licenses and Credentials Experience Knowledge, Skills and Abilities Additional Job Details (if applicable) Postdoctoral Fellow in ECoG/LFP of Speech Control An NIH-funded postdoctoral fellow position is available to study speech control in patients with dystonia and tremor using a combination of electrocorticography/local field potential (ECoG/LFP), electroencephalography (EEG), structural (MRI, DWI) and functional (fMRI, EEG) neuroimaging, and clinical-behavioral neurotesting. The postdoctoral fellows will function as part of a multi-disciplinary team of neuroscientists and clinicians. Responsibilities include participating in all aspects of data acquisition and management; developing, modifying, and executing analytical protocols; preparing publications and scientific presentations; disseminating results in peer-reviewed scientific journals and at major national and international meetings, and mentoring junior staff. Opportunities exist for excellent scientific interactions and collaborations with an extensive program of seminars, symposia, and other meetings focused on a large array of topics in neuroscience, neurosurgery, clinical research, and neurotechnology. Qualifications and Skills * A PhD or MD/PhD degree in Neuroscience, Biomedical Engineering, Mathematics, or related fields of biomedical sciences * Expertise in ECoG/LFP data processing and other methods of human brain imaging, including but not limited to fMRI, EEG, and DWI * Solid experience with scientific computing, including but not limited to computational (Python, MATLAB) and statistical (AFNI, FSL, SPM) methods * Strong experience in algorithmic design, mathematical models (primarily stochastic differential equation systems), and analysis and integration of dynamical systems * Independence and professional self-motivation with a proven track record of productive research * Ability to work effectively independently and collaborate on projects with multiple investigators * Strong written and verbal communication skills * Excellent academic credentials, including a strong publication record Remote Type Onsite Work Location 243-245 Charles Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Postdoctoral Position in Microendoscopy and In Vivo Imaging - Brigham and Women's Hospital / Harvard Medical School The Laboratory for Bio-Microdevices (LBMD) at Brigham and Women's Hospital (BWH) and Harvard Medical School is seeking an exceptional Postdoctoral Fellow to develop and apply next-generation microendoscopy technologies for microscopy-guided interventions and in vivo anti-cancer drug screening. This position builds on two breakthrough platforms developed in our lab: the first bendable graded-index (bGRIN) lens and the implantable microdevice (IMD) for localized drug testing in living tissues. The successful candidate will have the opportunity to tackle impactful, unmet biomedical challenges within a highly interdisciplinary team of engineers, biologists, and clinicians at a world-class medical research institution. Qualifications RESPONSIBILITIES: * Lead in vivo histopathological imaging of live tumors in animal models * Develop and execute protocols for in-situ immune response testing in tumors * Collaborate closely with clinicians to advance interventional IMD technology * Work with pathologists on tissue correlation and image analysis * Contribute to the ongoing development of bGRIN lens microendoscopy * Prepare scientific manuscripts, project reports, and patent applications * Present results within the group, at conferences, and in review meetings * Provide mentorship and training to research assistants and technicians REQUIREMENTS: * Ph.D. in biomedical engineering, biology, optics, electrical engineering, medicine, or other closely related fields * Demonstrated expertise in biomedical imaging, immunology, animal models, and image analysis * Hands-on experience with two-photon, confocal, and Raman imaging, is advantageous but not required * Excellent communication, time management, and multitasking skills * A strong publication record as first author in reputable journals in relevant fields The LBMD at BWH provides a vibrant research environment within the Harvard Medical School community. We maintain close collaborations with groups at MIT, Massachusetts General Hospital, and other institutions near the Boston area and across the country. This position offers outstanding opportunities for scientific growth, academic networking, and career advancement. More information about the LBMD can be found at: jonaslab.bwh.harvard.edu Interested candidates should submit: 1) a detailed CV; 2) a brief research statement (1-2 pages), and 3) contact information for three references. Additional Job Details (if applicable) Physical Requirements * Standing N/A = (0%) * Walking N/A = (0%) * Sitting N/A = (0%) * Lifting N/A = (0%) * Carrying N/A = (0%) * Pushing N/A = (0%) * Pulling N/A = (0%) * Climbing N/A = (0%) * Balancing N/A = (0%) * Stooping N/A = (0%) * Kneeling N/A = (0%) * Crouching N/A = (0%) * Crawling N/A = (0%) * Reaching N/A = (0%) * Gross Manipulation (Handling) N/A = (0%) * Fine Manipulation (Fingering) N/A = (0%) * Feeling N/A = (0%) * Foot Use N/A = (0%) * Vision - Far N/A = (0%) * Vision - Near N/A = (0%) * Talking N/A = (0%) * Hearing N/A = (0%) Remote Type Onsite Work Location 221 Longwood Avenue EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The Stanton Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital, Harvard Medical School, is seeking highly motivated post-doctoral Fellow candidates. The Stanton Laboratory develops and harnesses advanced bioengineered brain models to identify potential therapeutic strategies, coupling models to AI-driven approaches, while advancing precision medicine approaches and developing technologies for drug delivery to the brain to further facilitate translation. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and Research Fellow at the Harvard Medical School. The Post-Doctoral Fellow will develop and leverage next generation 3D iPSC-derived multicellular brain models for analyzing pathologies via multi-omics, drug testing, and AI-coupling. The Post-Doctoral fellow will be situated in the MGH under the guidance and mentorship of Dr. Alice Stanton. Qualifications The ideal candidate should have received (or expect to receive soon) a Ph.D. in Cell Biology, Neuroscience, Bioengineering, or related field. * First (or co-first) author of one or more high impact peer-reviewed scientific publications * Excellent English verbal and written communication skills * Able to work both independently and in a team * Expertise in iPSC culture, differentiation, and 3D co-cultures. * Expertise in cellular/molecular techniques including sc RNAseq, FACS, IHC, ELISA, PCR, and confocal microscopy. * Background in neurodegenerative disease modeling, ideally ALS or related pathologies. * Expertise in genetic engineering, including designing and optimizing genetic cassettes. * Strong analytical skills for phenotypic data interpretation and assay optimization. * Excellent organizational, communication, and teamwork abilities in a fast-paced research environment. Preferred Qualifications: * Experience with organ-on-chip development and high-content screening in organoids. * Experience with drug screening, pharmacology, ADMET profiling. * Experience with computational analysis of multi-omic data. * Experience with AI frameworks: NLP, GNN, RL, etc. * Familiarity with ALS patient cell repositories (e.g., NINDS, MGB). * Knowledge of AI frameworks. How to Apply: Please submit your CV, a cover letter detailing your relevant experience and interest in the project and contact information for three references to ************************* We look forward to having you join us in advancing the fight against ALS! Additional Job Details (if applicable) Remote Type Onsite Work Location 185 Cambridge Street EEO Statement: Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The Psychiatry Neuroimaging Laboratory at Brigham and Women's Hospital is seeking a full-time Postdoctoral Research Fellow to join our growing team. The fellow will work under the primary mentorship of Dr. Johanna Seitz-Holland, with additional guidance from Dr. Marek Kubicki. The fellow will be working on several funded projects examining psychosis across the lifespan using neuroimaging, clinical, and blood protein data. This is an exciting opportunity to contribute to impactful research while developing a strong foundation in translational psychiatry. We are a dynamic team committed to fostering a collaborative, supportive, and intellectually curious environment. Dr. Seitz-Holland takes mentoring seriously and is dedicated to creating a positive work atmosphere where team members can grow professionally and personally. We welcome applicants who are motivated, eager to learn, and excited to be part of a team working toward meaningful change in mental health research.The fellow will also have the opportunity to participate in the Stuart T. Hauser Research Training Program in Biological and Social Psychiatry (T32 position), which provides further structured training and career development support. Responsibilities include, but are not limited to: Assisting with quality control and curation of data collected as part of the psychosis projects. Processing imaging and blood data. Analyzing and modeling complex datasets, including neuroimaging, behavioral, and clinical data. Presenting at national and international meetings and building an active research/publication record. Assisting with grant writing. Supervising research assistants and undergraduate research trainees. Actively participating in the T32 training program. Qualifications Requirements: Ph.D. in Neuroscience, Clinical Neuroscience, Cognitive Science, Psychology, Engineering, Computer Science, or a related field. Background in data processing, statistics, biostatistics, or data modeling. Experience in processing and analysis of neuroimaging data is desired but not required. Strong verbal and written communication skills. Ability to work independently and collaboratively within a team. Demonstrated first-author publication record or pre-print experience. Most importantly, a genuine interest in psychiatry, motivation to work in a team, and excitement for research. Prior work authorization required (no visa sponsorship available). We're excited to learn more about you! To apply for this position, please email your resume directly to Johanna Seitz at **********************. Please do not apply through this link. Additional Job Details (if applicable) Remote Type Hybrid Work Location 399 Revolution Drive EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Summary In consultation with their Principal Investigator (PI), undertake and execute a program of scientific study culminating in publication. Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. They assist their PI in the training and supervision of other laboratory personnel and in a wide variety of administrative tasks, as necessary. Does this position require Patient Care? No Essential Functions * Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field. * Contributes to the design and execution of experiments and/or research projects. * Exercises judgment in selecting methods and technologies to obtain results. * May collaborate with external researchers and/or receive external project funding support. * Presents results and prepares publications. * May assist PI in the training and supervision of other staff. Qualifications This position in the BWH Center for Cellular Profiling offers the opportunity to join a group studying single-cell and Spatial organization in disease pathology. Our Center performs a combination of high-dimensional analyses, including single-cell RNA sequencing, spatial transcriptomics, and high-dimensional flow cytometry. Under general supervision by Drs. Brenner and Wei, and in accordance with established hospital policies and procedures, the self-motivated individual will perform activities related to the single-cell genomics and or flow cytometry cell sorting, including NGS library generation, 10X Genomics workflow (Chromium, Visium, and Xenium), and or familiarize with BD or Sony cell sorters and analyzers. Responsibilities includes the implementation and execution of single-cell and novel spatial transcriptomic techniques. In addition, the candidate will supervise trainees and technicians to perform NGS and 10X Genomics pipelines. The candidate will also conduct consultation with investigators and core users, perform troubleshooting, and work with administrative directors to support budget development and planning. 1. Designs and performs high-level, complex experiments independently. 2. Perform Single-cell Transcriptomics Experiments. a. Cell capture, NGS library generation, b. Plan library sequencing strategies. c. Review sequencing data d. troubleshoot techniques 3. Perform High-Parameters Flow Cytometry Experiments a. Perform cell sorting b. Maintenance of the cell sorters and analyzers c. Identify and resolve technical issues with flow cytometry instruments, maintaining equipment, and ensuring quality control. 4.Supervise research assistant trainees. 5.Provide consultation with new investigators and researchers 6.Maintain supplies inventory in accordance with laboratory and department procedures. 7.Assist in the orientation and training of new students, technicians, and fellows 8.Maintain established department policies, procedures and objectives, including the areas of quality assurance, safety, environmental and infection control. 9. Perform other duties as directed. Education Doctorate Related Field of Study required Can this role accept experience in lieu of a degree? No Licenses and Credentials Experience Previous Research experience (inclusive of graduate and postdoctoral experience) 5-7 years required Knowledge, Skills and Abilities * Excellent research skills. * Demonstrated evidence of specific scientific competence in field. * Demonstrated broad knowledge of field. * Evidence of potential for scientific creativity and original though. * Able to exercise independent judgment and leadership. * Ability to contribute to publications. Additional Job Details (if applicable) Remote Type Onsite Work Location 60 Fenwood Road Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary A research laboratory within the Brigham and Women's Hospital Division of Cardiovascular Medicine is seeking a highly motivated Research Scientist to join a growing, interdisciplinary team. The lab uses both in vitro (human ESC/iPSC) and in vivo (zebrafish) systems to model cardiovascular disorders and integrates transcriptional, (epi)genetic, metabolic, and phenotypic profiling at whole-organism, tissue, and single-cell levels. Our goal is to define the earliest molecular events driving disease onset, characterize their dynamic changes over time, and identify novel biomarkers and therapeutic targets. The Research Scientist will lead and directly perform automated, high-throughput microscopy screens to identify small-molecule compounds with improved efficacy over current clinical therapies. The role will involve hands-on execution of complex imaging workflows and the application of machine-learning approaches to large-scale imaging and phenotyping datasets. In addition, the Research Scientist will serve as the primary scientific point person for multiple industry collaborations, coordinating experimental design, execution, data generation, and communication between external partners and the lab. The Research Scientist will independently drive scientific projects, determine research direction in collaboration with the PI, and serve as an internal expert in automated imaging and computational analysis. The successful candidate will generate high-quality data, contribute substantially to scientific publications, mentor junior staff, engage with collaborators, and may participate in the development of external funding applications. Qualifications GENERAL SUMMARY/ OVERVIEW STATEMENT: A research laboratory within the Brigham and Women's Hospital Division of Cardiovascular Medicine is seeking a highly motivated Research Scientist to join a growing, interdisciplinary team. The lab uses both in vitro (human ESC/iPSC) and in vivo (zebrafish) systems to model cardiovascular disorders and integrates transcriptional, (epi)genetic, metabolic, and phenotypic profiling at whole-organism, tissue, and single-cell levels. Our goal is to define the earliest molecular events driving disease onset, characterize their dynamic changes over time, and identify novel biomarkers and therapeutic targets. The Research Scientist will lead and directly perform automated, high-throughput microscopy screens to identify small-molecule compounds with improved efficacy over current clinical therapies. The role will involve hands-on execution of complex imaging workflows and the application of machine-learning approaches to large-scale imaging and phenotyping datasets. In addition, the Research Scientist will serve as the primary scientific point person for multiple industry collaborations, coordinating experimental design, execution, data generation, and communication between external partners and the lab. The Research Scientist will independently drive scientific projects, determine research direction in collaboration with the PI, and serve as an internal expert in automated imaging and computational analysis. The successful candidate will generate high-quality data, contribute substantially to scientific publications, mentor junior staff, engage with collaborators, and may participate in the development of external funding applications. PRINCIPAL DUTIES AND RESPONSIBILITIES: * Provide overall scientific leadership and project management for assigned research initiatives, including direct execution of experimental work. * Design, optimize, and perform high-throughput automated imaging and screening assays, including day-to-day hands-on operation of imaging platforms and related instruments. * Conduct complex and innovative experiments using in vitro (human ESC/iPSC) and in vivo (zebrafish) models; troubleshoot technical challenges and refine protocols as needed. * Serve as a subject-matter expert while actively generating data, maintaining experimental quality, and ensuring reproducibility. * Exercise professional judgment in selecting experimental strategies, technologies, and analytical methods to obtain high-quality results. * Make project-level decisions to address and resolve critical scientific or technical challenges. * Regularly present results to the PI and contribute to preparation of manuscripts, reports, and presentations. * Collaborate with external partners as the scientific point person for industry-funded projects, ensuring high-quality and timely experimental deliverables. * Maintain an active publication record as senior author or substantial contributor, demonstrating scientific independence. * Participate in relevant scientific societies, committees, and professional activities. * Train and mentor junior research staff in laboratory techniques, data analysis approaches, and best practices in research execution. * Contribute to long-term strategic planning for the laboratory's research direction, technologies, and collaborative projects. QUALIFICATIONS: * PhD in molecular biology, molecular genetics, or a closely related field strongly preferred; an MS with substantial additional experience may be considered. * Prior experience with zebrafish research is required. * Minimum of 5 years of relevant research experience, including demonstrated independence. SKILLS/ ABILITIES/ COMPETENCIES REQUIRED: * Strong expertise and technical proficiency in molecular biology, cell biology, and genetics. * Demonstrated experience using model organisms (preferably zebrafish) for high-throughput drug or modifier screens. * Proven ability to design, execute, and troubleshoot complex research projects. * Ability to define project objectives, develop experimental approaches, and interpret results. * Strong scientific writing skills with a record of impactful contributions to peer-reviewed publications. * Excellent organizational, communication, and leadership skills. * Ability to work both independently and collaboratively within a multidisciplinary research team. WORKING CONDITIONS: Wet-lab/office setting. SUPERVISORY RESPONSIBILITY: May be responsible for managing junior staff or research assistants. Additional Job Details (if applicable) Remote Type Onsite Work Location 221 Longwood Avenue Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

This is an opportunity to join Ordovas-Montanes Lab, which specializes in understanding how inflammation drives memory formation in barrier tissues with the goal of developing new therapeutic avenues for human disease. This candidate will contribute to a collaborative project focused on mucosal immunity to respiratory infection and vaccination. The candidate will work under the direct supervision of Dr. Jose Ordovas-Montanes and be closely integrated within a community of senior scientists, graduate students, and postdoctoral fellows. This position requires substantial technical expertise, the ability to troubleshoot specialized assays, and the capacity to support and train junior lab members as needed. This role offers the opportunity to develop a wide range of experimental and computational skills while working in an interdisciplinary environment with access to resources across Boston Children's Hospital and Harvard Medical School. The ideal candidate is motivated to understand the biological principles underlying infection-induced inflammatory diseases and may be interested in pursuing future postgraduate education. Key Responsibilities: * Independently perform complex experimental workflows, help optimize protocols, and generate high-quality data for single-cell genomics and airway epithelial biology studies. * Troubleshoot specialized assays. * Support and train junior lab members as needed. * Performs routine and highly specialized lab experiments using sophisticated and intricate research equipment and techniques. Performs and devises specialized experiments and research procedures, troubleshooting problems with own and other researchers' results. * Assists other lab personnel with the use of specialized equipment and techniques within the lab. Minimum Qualifications Education: * Bachelor's degree in biology, immunology, genomics, chemistry, or a related field is required. Master's degree preferred but not required. Experience: * Bachelor's and 4 years of relevant experience OR a Master's of Science and 2 years of relevant experience. * Demonstrated experience performing mammalian cell culture, ideally primary airway epithelial culture or similar complex systems. * Proficiency in molecular biology techniques. * Proven ability to independently execute and troubleshoot complex laboratory workflows. * Experience with single-cell RNA-sequencing methods and data analysis in R and/or python is preferred but not required. The posted pay range is Boston Children's reasonable and good-faith expectation for this pay at the time of posting. Any base pay offer provided depends on skills, experience, education, certifications, and a variety of other job-related factors. Base pay is one part of a comprehensive benefits package that includes flexible schedules, affordable health, vision and dental insurance, child care and student loan subsidies, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition and certain License and Certification Reimbursement, cell phone plan discounts and discounted rates on T-passes. Experience the benefits of passion and teamwork.

The **Center for Cancer Genomics** **(CCG)** at Dana-Farber Cancer Institute facilitates genomic discoveries in cancer using novel technology platforms to assist researchers in both genome-wide and gene-focused efforts. Technologies are selected and developed with a view to research-oriented ventures, as well as translational medicine and clinical relevance. Our clinical and research environments currently use state-of-the-art massively parallel sequencing assays of DNA and RNA from patient tumor samples. Data from these environments are used to advance research on both adult and pediatric cancers, improve our understanding of cancer biology, and advance the field of precision cancer medicine. This opportunity offers the chance to work at the forefront of translational cancer technologies and applications, in an informatics group that enables analyses in both arenas. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. The **Bioinformatician II** will report to CCG's Lead Informaticist and have the main responsibility of independently performing data analysis on a wide array of cancer multiomics projects ( _sc/sn RNAseq, sc ATACseq, Crispr screens, SNV/CNV, longread Oxford Nanopore Direct RNA sequencing,_ etc.) in consultation and collaboration with internal Dana-Farber research collaborators and external research partners. Some limited orchestration of automated pipelines may be required as necessary. The Bioinformatician II will have no direct reports. Dana-Farber has a wealth of local, on-premises, and cloud-based computing resources available to extensively explore the large body of data generated annually by Dana-Farber researchers and collaborators. Given these resources, the development of novel computational methods is strongly encouraged. **MINIMUM JOB QUALIFICATIONS:** Minimum Education: Bachelor's degree required in a STEM field. Master's degree or PhD strongly preferred in bioinformatics, medical informatics, computational biology, statistics, computer science/engineering, or a related quantitative field. Minimum Education: 3 Years of experience required; Master's degree with 1 year experience required; PhD with 0 years. + Experience with bioinformatics tools and databases for sequence alignment/analysis; germline and somatic variant calling; bulk and single-cell/nuclei RNAseq; long read sequencing (Oxford Nanopore). + Proficiency in programming languages commonly used in bioinformatics and data analysis, such as Python, R, and Perl. Experience with workflow languages such as WDL or Nextflow is a plus. + Excellent communication skills and ability to work collaboratively in multi-disciplinary team. **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $83,800 - $90,800 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**

A computationally-oriented team led by Rameen Beroukhim and Simona Dalin at the Dana-Farber Cancer Institute and Broad Institute seeks an associate computational biologist to join in efforts to develop and apply cutting-edge genomic algorithms and analyses to characterize genomic rearrangements in cancers and normal tissues, and better understand how errors in double strand break (DSB) repair result in these rearrangements. This individual will contribute to a lively team and wider community of laboratory scientists, computational biologists, cancer geneticists, and software engineers dedicated to discovering and understanding the alterations in the cancer genome and discovering cancer vulnerabilities that could lead to new therapeutics. We are looking for a person who wants to lead their projects, think independently and make original intellectual contributions. We welcome all levels of input from our ACBs, including input on the conduct of analyses but also on new analyses to conduct and new questions to ask. ACBs in our laboratory regularly present their own work and contribute to the writing of papers and grant applications. We view an ACB as a mentored training position, with a primary goal being their professional development. Our prior ACBs have successfully pursued a variety of subsequent career directions including obtaining MDs, PhDs, and MD-PhDs on the paths to careers in both academia and industry. The ideal candidate will have extensive programming ability and a strong background in mathematics and statistics with a deep interest and background in biology. The candidate is required to have a B.S./B.A. or equivalent, ideally in the life sciences, physical sciences, or computational sciences; prior research in one of these areas (for example, a summer research program or several hours a week in a lab as an undergraduate); a strong background in programming, preferably in R and BASH; knowledge of statistical methods either through coursework or research; and excellent written & verbal communication skills. They must be a self-starter with excellent problem-solving, organizational and people skills and be able to collaborate closely with other members of a research team. We prefer the candidate to have exposure to an analytic field such as bioinformatics, computational biology, machine learning, or statistics and experience working in cloud computing and UNIX environments. A minimum 2 year commitment is required. Ideally we are looking for someone to join our lab before March 2026 but we are also considering applicants who will complete their current degree program in Spring 2026. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. + Data Processing Builds data processing pipelines to convert raw data into formats compatible with conventional statistical analysis and visualization under supervision of mentor. + Data Analysis: Follows a detailed manual to perform routine. + Data and Software Management: Monitors, downloads, organizes, and manages data from public data repositories or generated by collaborates. + Manuscript Preparation: Helps prepare tables and figures. + Research Portfolio Management: Trains to develops timelines and components for multiple routine projects; masters multi-tasking so that complex projects involving many interdisciplinary individuals move forward smoothly. **MINIMUM JOB QUALIFICATIONS:** Minimum Education: Bachelor's degree required in a STEM field required. Minimum Experience: No prior experience required **.** **KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED:** + Computational Skills: Knowledge of UNIX/Linux. Familiarity with scripting in Python and statistical programming using R. + Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. + Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. + Strong interpersonal skills - ability to effectively interact with all levels of staff and external contacts. + Excellent analytical, organizational and time management skills. **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $60,000 - $67,466 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**

A computationally-oriented team led by Rameen Beroukhim and Simona Dalin at the Dana-Farber Cancer Institute and Broad Institute seeks an associate computational biologist to join in efforts to develop and apply cutting-edge genomic algorithms and analyses to characterize genomic rearrangements in cancers and normal tissues, and better understand how errors in double strand break (DSB) repair result in these rearrangements. This individual will contribute to a lively team and wider community of laboratory scientists, computational biologists, cancer geneticists, and software engineers dedicated to discovering and understanding the alterations in the cancer genome and discovering cancer vulnerabilities that could lead to new therapeutics. We are looking for a person who wants to lead their projects, think independently and make original intellectual contributions. We welcome all levels of input from our ACBs, including input on the conduct of analyses but also on new analyses to conduct and new questions to ask. ACBs in our laboratory regularly present their own work and contribute to the writing of papers and grant applications. We view an ACB as a mentored training position, with a primary goal being their professional development. Our prior ACBs have successfully pursued a variety of subsequent career directions including obtaining MDs, PhDs, and MD-PhDs on the paths to careers in both academia and industry. The ideal candidate will have extensive programming ability and a strong background in mathematics and statistics with a deep interest and background in biology. The candidate is required to have a B.S./B.A. or equivalent, ideally in the life sciences, physical sciences, or computational sciences; prior research in one of these areas (for example, a summer research program or several hours a week in a lab as an undergraduate); a strong background in programming, preferably in R and BASH; knowledge of statistical methods either through coursework or research; and excellent written & verbal communication skills. They must be a self-starter with excellent problem-solving, organizational and people skills and be able to collaborate closely with other members of a research team. We prefer the candidate to have exposure to an analytic field such as bioinformatics, computational biology, machine learning, or statistics and experience working in cloud computing and UNIX environments. A minimum 2 year commitment is required. Ideally we are looking for someone to join our lab before March 2026 but we are also considering applicants who will complete their current degree program in Spring 2026. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. Responsibilities * Data Processing Builds data processing pipelines to convert raw data into formats compatible with conventional statistical analysis and visualization under supervision of mentor. * Data Analysis: Follows a detailed manual to perform routine. * Data and Software Management: Monitors, downloads, organizes, and manages data from public data repositories or generated by collaborates. * Manuscript Preparation: Helps prepare tables and figures. * Research Portfolio Management: Trains to develops timelines and components for multiple routine projects; masters multi-tasking so that complex projects involving many interdisciplinary individuals move forward smoothly. Qualifications MINIMUM JOB QUALIFICATIONS: Minimum Education: Bachelor's degree required in a STEM field required. Minimum Experience: No prior experience required. KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED: * Computational Skills: Knowledge of UNIX/Linux. Familiarity with scripting in Python and statistical programming using R. * Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. * Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. * Strong interpersonal skills - ability to effectively interact with all levels of staff and external contacts. * Excellent analytical, organizational and time management skills. Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $60,000 - $67,466 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEOC Poster

The laboratory of Zuzana Tothova, MD, PhD is a multi-disciplinary team of physician scientists, scientists and computational biologists at the Dana-Farber Cancer Institute and the Broad Institute. Our laboratory uses genomics and a range of molecular and cellular biological techniques to elucidate the molecular basis of cancer and hematologic disorders and to develop novel therapeutics. Our specific focus is to understand the role of chromatin modifiers and epigenetic factors and find novel therapeutic opportunities in myeloid malignancies, including myelodysplastic syndromes and acute myeloid leukemia. JOB TITLE: Associate computational biologist FLSA: Full-time, on-site REPORTS TO: Zuzana Tothova, M.D., Ph.D.DEPT: Medicine Oncology/ Heme Neoplasia General Summary A full-time associate computational biologist position is available in the laboratory of Zuzana Tothova, M.D., Ph.D. at Dana-Farber Cancer Institute. We are seeking enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging research environment, and can interact well with others as part of a cohesive team. If you have a desire to make a significant impact in healthcare and have the fortitude to work hard, you will succeed within this team. This is an ideal entry-level or mid-level position into the world of cutting-edge laboratory research. A growth mindset and a willingness to take on challenging learning opportunities will be sought out traits. Ideal candidates will possess strong interpersonal skills along with a desire to help others to succeed. Previous team members have gone on to successful academic and career opportunities; graduate/medical school and industry. The candidate will be involved in a series of research activities, including computational analysis of large-scale data sets generated in in vitro and in vivo human disease relevant models and use of next generation sequencing with a special emphasis on understanding the biology of human myeloid malignancies. The Associate Computational Biologist is training to become a Computational Biologist. They are responsible for routine data analysis or processing of biological data, with a focus on high-throughput technologies and genomic databases, under the supervision of mentor. The Computational Biologist is a quantitative scientist who collaborates with scientific investigators and with other research staff in the analysis of high-throughput data, and dissemination of scientific results. The Computational Biologist may work on many types of projects and areas of research including cancer genomics, functional genomics, immuno-oncology, molecular imaging, data management and integration, and querying biological databases. We are looking for candidates with at least 2 years of availability. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. Responsibilities PRIMARY DUTIES AND RESPONSIBILITIES: Data Processing Builds data processing pipelines to convert raw data into formats compatible with conventional statistical analysis and visualization under supervision of mentor. Data Analysis: Follows a detailed manual to perform routine. Data and Software Management: Monitors, downloads, organizes, and manages data from public data repositories or generated by collaborates. Manuscript Preparation: Helps prepare tables and figures. Research Portfolio Management: Trains to develops timelines and components for multiple routine projects; masters multi-tasking so that complex projects involving many interdisciplinary individuals move forward smoothly. Works closely with postdoctoral fellows and graduate students in the lab and computational biology collaborators at the Dana-Farber Cancer Institute and the Broad Institute to analyze biological data sets, including but not limited to DNA and RNA sequencing, gene expression and transcriptome analysis, chromatin landscape profiling, and analysis of microscopy/imaging data. Modifies and maintains existing data-processing pipelines in the lab, and develops new pipelines and tools to analyze novel forms of data, including data cleaning, normalization, and visualization. Integrates multiple data sets to answer targeted scientific questions. Documents and compiles findings in oral and written reports. Attends team meetings to share results, plan projects and experiments. Maintains and improves technical knowledge base. Other related tasks as required. KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED: * Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. * Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. * Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. Qualifications MINIMUM JOB QUALIFICATIONS: Minimum Education: Bachelor's degree in a computer science or related-STEM field required. Minimum Experience: No prior experience required. KNOWLEDGE, SKILLS, AND ABILITIES REQUIRED: * Computational Skills: Knowledge of UNIX/Linux. Proficiency with scripting in Python and statistical programming using R. * Data analysis Skills: Familiarity with principles of experimental design and the modern data analysis paradigms is required. * Collaboration: Able to discuss and present results, share ideas accurately and communicate them effectively, both in writing and verbally with supervisory oversight. * Strong interpersonal skills - ability to effectively interact with all levels of staff and external contacts. * Excellent analytical, organizational and time management skills. * Familiarity with bioinformatics data types and software preferred * Familiarity with GitHub and HPC preferred * Passion for science and strong motivation required. * Must be a strong team player. * Strong interpersonal, communication and organizational skills, including the ability to handle a variety of tasks in a fast-paced environment, positive attitude and attention to detail, as well as ability to think on one's feet are required. * Must possess a high level of initiative, curiosity and dedication, proactivity in identifying problems and solutions to address them. * Familiarity with bioinformatics data types (e.g. FastQ, BAM, BigWig) and software (e.g. DeepTools, MACS, HOMER) preferred. * Familiarity working with Git repositories preferred. * Familiarity with computational methods for single-cell sequencing data preferred. Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $60,000 - $67,466 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEOC Poster