Research Laboratory Technician jobs at Dana-Farber Cancer Institute

A **RESEARCH TECHNICIAN** position is available in the laboratory of Dr. Yana Pikman (*********************************** at the Dana-Farber Cancer Institute. Our research focuses on the application of clinical genomics for development of targeted therapy approaches for acute leukemia, drug testing and combination screening with the ultimate goals of 1) improving understanding of leukemia biology and 2) translating bench discovery to clinical care. You will join a team of investigators leading these efforts in the academic environment, working at the bench, collaborating closely with scientists as well as clinical researchers. You will play an essential, and possibly leading, role in project-focused work. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. + Conduct bench level experiments to support the goals of scientific research in leukemia and genomics + Maintain cell lines and isolate primary cells for use in cell based assays + Performing a variety of basic cancer biology assays, including in vitro proliferation or apoptosis assays, drug sensitivity assays, flow cytometry and western blotting, _in vivo_ xenograft experiments + Performing a variety of molecular biology assays- cloning, PCR, DNA/RNA isolation + Lentiviral transduction techniques for ORF-overexpression experiments or CRISPR-Cas9 knockdown/knockout experiments + Operate and maintain laboratory equipment to complete investigations + Prepare, order, and maintain stocks of necessary reagents, solutions and supplies + Document, compile, and analyze experimental data. Troubleshoot and solve scientific problems with supervision + Report data in oral and written formats + Monitors laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory. + Expected to provide intellectual and interactive commitment to position by keeping up with appropriate literature and research publications. + May be responsible for designing and executing advanced experiments and setting strategy. + Participate in team meetings for experimental planning, discussion of projects and general learning + Participate in research meetings at the DFCI and Boston Children's Hospital + Bachelor's degree in Biology or related field required, or equivalent combination of education and experience + 1-2 years prior laboratory experience is strongly desired but not absolutely required. More experienced applicants who have worked for multiple years as a professional scientist or research technician are also encouraged to apply and would be considered at an appropriate level of compensation and benefits. + A history of hard work and sound academic achievement is required. + Familiarity with basic laboratory techniques and principles of molecular biology + Experience working in a medical or scientific research setting or comparable technology-oriented business environment + Knowledge of computers and experience with databases + Ability to analyze information and use logical reasoning to address work-related issues and problems. + Ability to work within a team environment. + Must have attention to detail and be thorough in completing work tasks. + Excellent written and oral communication skills + Strong organizational skills, including the ability to handle a variety of tasks in a fast-paced environment required + We are looking for candidates with a minimum of two years of availability. Candidates with laboratory technician experience and those potentially interested in a long term position are encouraged to apply. **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $47,500 - $51,300 **APPLY** : Please apply on our careers page. You can e-mail a cover letter/letter of interest to: Yana Pikman, MD Principal Investigator Yana_*********************** At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary We are seeking an experienced Research Technologist to lead our noninvasive fetal sequencing project (NIFS). Standard noninvasive prenatal testing (NIPT) relies on cell-free DNA (cf DNA) analysis from maternal plasma but is restricted to detecting common aneuploidies and some microdeletions. We have developed a high-resolution, noninvasive fetal sequencing approach that can detect clinically significant fetal variants with comparable accuracy to NIPT, eliminating the procedural risk of invasive testing. The candidate will be responsible for optimizing our current NIFS protocol to improve our cf DNA recovery and to validate those results against the current diagnostic gold standard. The Talkowski Laboratory in the Center for Genomic Medicine at Massachusetts General Hospital (MGH) and the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard are seeking a motivated, enthusiastic, experienced leader to join our research teams. Our group explores the impact of genomic variation on human disease, with a particular focus on the relationship between genome structure and function. We are dedicated to the development and application of innovations in genome sequencing technologies and genetic diagnostics. Our research has shown that we can use NGS techniques to more fully capture prenatal. The candidate will be expected to have experience or a high capacity to learn the following techniques: * Handling of human blood-derived samples, including isolation of plasma and buffy coat under sterile and reproducible conditions. * Sample processing, labeling, and biobanking under rigorous quality control and contamination-prevention measures consistent with good laboratory practice (GLP) standards. * Extraction and robust handling of cell-free DNA (cf DNA) and genomic DNA (gDNA) from plasma, blood, and human tissues. * Next-generation sequencing (NGS) library preparation for low-input cf DNA/gDNA samples and target hybridization protocols for exome and custom sequencing panels. * Sanger sequencing, gel electrophoresis, PCR, and qPCR-based assays for cf DNA quantification, variant detection, and workflow validation. * NGS library quality control and assessment, including quantification and fragment size analysis. * Accurate sample tracking and documentation across all stages of processing and analysis. Does this position require Patient Care? No Essential Functions * Perform DNA/RNA extraction from blood samples (incl. whole blood, buffy coat, plasma). * Perform other molecular genomics procedures as needed (i.e., sequencing library production, target hybridization, RNAseq, sample archiving, tissue culture, etc.) * Learn and perform any number of molecular genomics techniques, including single-cell RNAseq (sc RNAseq), ATACseq, ChIPseq, HiC, and other methods * Independently performs non-routine, highly specialized experimental procedures. * Participates in the design and modification of research protocols. * Develops research methodologies within the parameters of experimental protocols and research objectives. * Composes and may present sections of research reports and manuscripts. * Performs advanced data analysis using advanced statistical techniques. * Responsible for the oversight and coordination of lab activities, including quality assurance. * Responsible for the oversight and coordination of the scheduling of all procedures. * Responsible for troubleshooting problems and instructing others in highly specialized techniques. Qualifications Education Bachelor's Degree Related Field of Study required Can this role accept experience in lieu of a degree? Yes Licenses and Credentials Experience Previous Research Lab Experience 3-5 years required Knowledge, Skills and Abilities * Organize and maintain a functioning research laboratory. * Troubleshoot scientific and non-scientific problems. * Proficiency in Word, PowerPoint, Excel, and Internet searches is preferred. * Well-versed in laboratory standards and practices. * May teach moderately difficult-to-complex lab techniques to students and research personnel. * May provide functional guidance to lower level technical personnel. Additional Job Details (if applicable) Remote Type Onsite Work Location 185 Cambridge Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $62,004.80 - $90,750.40/Annual Grade 7 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Summary: Carries out a broad range of technically advanced research activities and procedures; evaluates conclusions and has considerable latitude to modify or devise methods and techniques as necessary to achieve desired results; typically supervises technical and sometimes administrative elements of the research unit. Does this position require Patient Care? No Essential Functions: * Executes protocols of non-routine experiments. * Assists PI with determining the most suitable methodology. * Performs basic design and modification of protocols. * Calculates, transcribes, and analyzes data. * Prepares and presents reports. * Organizes and summarizes acquired data using scientific and Statistical Techniques. * Participates in the design of experiments or field work. Qualifications Education Bachelor's Degree Related Field of Study required Experience Previous Research Lab Experience 1-2 years required Knowledge, Skills and Abilities * Analytical skills and ability to resolve technical problems. * Ability to interpret acceptability of data results. * Strong Computer skills. * Demonstrated competence in research techniques and methodologies. * Excellent interpersonal and collaborative skills. * Ability to work independently and as part of a team. Additional Job Details (if applicable) We are seeking a motivated and detail-orientated research technician to join the Genomics Platform at The Gene Lay Institute of Immunology and Inflammation of Brigham and Woman's Hospital, Massachusetts General Hospital, and Harvard Medical School. The Institute aims to understand the immunologic mechanisms behind inflammatory diseases, cancer, and aging with the ultimate goal of identifying novel therapeutic targets. The Genomics Platform offers a range of next generation sequencing and spatial omics technologies and services, and utilizes state of the art robotics systems and the latest technologies and methods to generate high-quality, comprehensive genomics data. This position will work closely with the Platform Manager, Project Manager, and Data Manager to assist in data generation and processing, as well as maintain laboratory equipment and support experimental workflows. Looking for an applicant with molecular biology experience and strong organizational skills/attention to detail. This position will directly interface with researchers and requires strong communication skills. This position involves extensive training at the initial stage, and hence requires a two-year commitment minimum. Principal Duties and Responsibilities: * Under supervision of or assisting the Platform Manager, provide next generation sequencing and spatial transcriptomics services, including single cell and bulk RNA-sequencing library preparation, spatial omics, and other workflows as needed. * Carefully maintain records/logs of Genomics Platform projects. This includes sample tracking, archiving, and storage. * After proper training, perform sectioning, staining, and histology quality control for spatial omics projects. * Perform in vitro and in vivo experiments run by the Genomics Platform. * Maintain all equipment within the Platform to keep them in good working order. Work with vendors to schedule preventative maintenance visits and coordinate all repairs needed for the equipment. * Track inventory, order supplies, receive and log orders to maintain adequate stock of Genomics Platform consumables. * Serve as the emergency response personnel required to respond to equipment failure during off hours. (e.g. freezer failure). * Performs all other duties as directed by the Platform Director, Manager, and Project Manager. Preferred Skills: * High degree of computer literacy. * Sound analytical and organizational skills. * Good oral and written communication skills. * Must be able to logically and effectively structure tasks and set priorities. Remote Type Onsite Work Location 60 Fenwood Road Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $23.80 - $34.81/Hourly Grade 6 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Dr. Catarina Silva, Assistant Professor in the Department of Neurology and Center for Genomic Medicine at Massachusetts General Hospital, leads a research group within the Chemical Neurobiology Laboratory (CNL) focused on neurodegeneration, molecular biology, and drug discovery. The Silva Lab uses patient-derived iPSC neuronal models to study tauopathies and collaborates closely with both academic and biotech partners in a fast-paced, translational research environment. The Research Technician II will apply a background in molecular biology, neuroscience, or a related field. This position involves culturing human iPSCs, neural progenitor cells (NPCs), and neurons; performing small-molecule treatments and cellular assays; and conducting protein biochemistry experiments. Utilize a strong work ethic, excellent organizational and record-keeping skills, and the ability to plan and prioritize tasks independently over time. Will be open to feedback, committed to scientific rigor, and excited to contribute to high-impact research at the intersection of neuroscience and therapeutic development. Will demonstrate enthusiasm, eagerness to learn and work effectively in a team-oriented setting. Qualifications Principal Duties And Responsibilities * Primary responsibilities include maintenance of human iPSC cultures, neuronal differentiation, and preparation of cells for drug treatment assays and downstream analysis, with a major focus on western blot and related biochemical assays. * Plans and organizes experiments with long timelines, often requiring setup weeks to months in advance; success in this role requires strong organizational skills, attention to detail, and ability to anticipate experimental needs. * Performs experimental work related to small-molecule treatments, phenotypic assays (e.g., viability assays, immunocytochemistry), and data collection. * May occasionally assist with the processing of animal or human brain tissue for protein or RNA extraction and downstream molecular analysis. * Reads and follows experimental protocols; after training, independently plans weekly schedule and executes assigned experiments with minimal supervision. * Identifies and communicates issues during experiments; participates in troubleshooting discussions with the PI and lab team. * Adapts protocols as needed to improve experimental outcomes or address specific project needs. * Analyzes experimental results, prepares statistical and graphical summaries, and contributes to data interpretation. * Maintains accurate and up-to-date electronic lab notebooks, protocols, and inventory records. * Prepares written and oral reports for internal meetings; assists in the preparation of figures, presentations, manuscripts, and grant materials. * Performs literature searches to support experimental design, data interpretation, and troubleshooting. * Prepares laboratory reagents and solutions; assists with ordering supplies and maintaining stock of chemicals and materials. * Contributes to general lab maintenance and organization, including shared equipment care and workspace cleanliness. * Help train and orient new lab members, including Research Technicians and Fellows. * Contribute to experimental design and selection of appropriate methodologies in collaboration with the PI; participate in the design and execution of non-routine or complex experiments. * Modify and optimize existing protocols or help develop new assay techniques. * Organize, analyze, and interpret experimental data using appropriate scientific and statistical methods. * Assist in drafting or editing research manuscripts, presentations, and other scientific documents. Skills, Abilities & Competencies Required * Research experience, ideally involving cell culture and/or human neuronal cell lines and hands-on experience with core molecular biology techniques, including western blot (priority), qRT-PCR and molecular cloning. * Proficiency in basic laboratory math required for molecular biology, such as calculating molarity, preparing dilutions, and generating or interpreting standard curves. * Work independently by following detailed protocols and personal notes, execute experiments accurately. Also collaborates effectively as part of a team. * Strong organizational skills with the ability to plan and manage an experimental schedule to maximize productivity. Multi-tasking skills. * Excellent attention to detail and capacity to multitask across projects and timelines. * Effective communication and interpersonal skills. * Computer literacy and proficiency in data entry, electronic documentation, and basic data analysis and graphic visualization (e.g., Excel, GraphPad Prism). * A proactive mindset, reliability, and scientific curiosity are essential, as is the ability to work both independently and collaboratively in a fast-paced, team-oriented environment. * · Strong analytical and problem-solving skills, including the ability to troubleshoot experiments. * Ability to assess data quality and interpret experimental outcomes. * Familiarity with data management and analysis tools. * Demonstrated competence with research methodologies and experimental techniques. Education Bachelor's Degree required (Ideally in Biochemistry, Molecular Biology or related scientific field). Previous Experience At least 2 years of hands-on experience in a wet lab setting. * Prior experience with neuronal cell culture and biochemical techniques such as western blotting are a plus. * Familiarity with other molecular biology methods (e.g., PCR, cloning, CRISPR editing) is also highly desirable. Experience with animal work-such as brain dissections and tissue processing for protein or RNA analysis-will be highly regarded. Supervisory Responsibility None. A Research Technician II may serve as a mentor to Students and Research Technician I staff, providing guidance on specific experiments or protocols as needed. Working Conditions Research laboratory with typical hazards including chemicals, fumes and sharp instruments. Periods of prolonged standing and computer work may occur as well as other physical requirements such as walking. This role may occasionally require flexible scheduling, including rare weekend work, to support ongoing cell culture maintenance or time-sensitive experiments. Fiscal Responsibility Prudent use of hospital resources. Cost-effective ordering of supplies. Additional Job Details (if applicable) Remote Type Onsite Work Location 185 Cambridge Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $23.80 - $34.81/Hourly Grade 6 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Summary: Responsible for maintaining laboratory equipment, organizing and preparing samples, conducting experiments, and recording and analyzing data. Does this position require Patient Care? No Essential Functions: * Perform laboratory experiments following established protocols and procedures. * Prepare and handle samples, reagents, and solutions, ensuring accuracy and adherence to safety guidelines. * Operate and maintain laboratory equipment and instruments, conducting routine calibration and troubleshooting as needed. * Record experimental data accurately and maintain organized records of procedures, protocols, and results. * Compile and analyze data using appropriate statistical and analytical methods. * Assist in data interpretation and presentation, contributing to research findings and reports. Qualifications Education Bachelor's Degree Related Field of Study required Experience Prior laboratory experience, either through academic coursework, internships, or employment 1-2 years preferred Knowledge, Skills and Abilities * Strong theoretical and practical knowledge of laboratory techniques and procedures. * Familiarity with common laboratory equipment and instruments used in research experiments. * Proficiency in data collection, analysis, and scientific software tools. * Excellent attention to detail, organizational skills, and the ability to multitask and prioritize tasks effectively. * Strong problem-solving skills and the ability to troubleshoot technical issues. * Excellent written and verbal communication skills to effectively convey experimental procedures, results, and challenges. * Excellent interpersonal and collaborative skills. * Ability to work independently and as part of a team. Additional Job Details (if applicable) We are seeking a motivated and detail-orientated research technician to join the Genomics Platform at The Gene Lay Institute of Immunology and Inflammation of Brigham and Woman's Hospital, Massachusetts General Hospital, and Harvard Medical School. The Institute aims to understand the immunologic mechanisms behind inflammatory diseases, cancer, and aging with the ultimate goal of identifying novel therapeutic targets. The Genomics Platform offers a range of next generation sequencing and spatial omics technologies and services, and utilizes state of the art robotics systems and the latest technologies and methods to generate high-quality, comprehensive genomics data. This position will work closely with the Platform Manager, Project Manager, and Data Manager to assist in data generation and processing, as well as maintain laboratory equipment and support experimental workflows. Looking for an applicant with molecular biology experience and strong organizational skills/attention to detail. This position will directly interface with researchers and requires strong communication skills. This position involves extensive training at the initial stage, and hence requires a two-year commitment minimum. Principle Duties and Responsibilities: * Under supervision of or assisting the Platform Manager, provide next generation sequencing and spatial transcriptomics services, including single cell and bulk RNA-sequencing library preparation, spatial omics, and other workflows as needed. * Carefully maintain records/logs of Genomics Platform projects. This includes sample tracking, archiving, and storage. * After proper training, perform sectioning, staining, and histology quality control for spatial omics projects. * Perform in vitro and in vivo experiments run by the Genomics Platform. * Maintain all equipment within the Platform to keep them in good working order. Work with vendors to schedule preventative maintenance visits and coordinate all repairs needed for the equipment. * Track inventory, order supplies, receive and log orders to maintain adequate stock of Genomics Platform consumables. * Serve as the emergency response personnel required to respond to equipment failure during off hours. (e.g. freezer failure). * Perform all other duties as directed by the Platform Director, Manager, and Project Manager. Preferred Skills: * High degree of computer literacy. * Sound analytical and organizational skills. * Good oral and written communication skills. * Must be able to logically and effectively structure tasks and set priorities. Remote Type Onsite Work Location 60 Fenwood Road Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $19.76 - $28.44/Hourly Grade 5 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. This position is open at the Research Technician I or II level depending on the candidate's prior experience. The selected individual will support interdisciplinary projects on neuroimmune mechanisms in Alzheimer's disease, working under the supervision of Dr. Mehdi Jorfi in the Department of Neurology, MGH, and Harvard Medical School. Start date is immediate or as soon as possible, depending on candidate availability. Prior experience with cell culture, immunostaining, animal models or bioengineering techniques is preferred but not required. Job Summary Summary Responsible for maintaining laboratory equipment, organizing and preparing samples, conducting experiments, and recording and analyzing data. Candidates who are in the process of completing their bachelor's degree have a grace period of six months from their hire date (up to 1 year if starting per diem) to provide degree equivalency verification. Does this position require Patient Care? No Essential Functions * Perform laboratory experiments following established protocols and procedures. * Prepare and handle samples, reagents, and solutions, ensuring accuracy and adherence to safety guidelines. * Operate and maintain laboratory equipment and instruments, conducting routine calibration and troubleshooting as needed. * Record experimental data accurately and maintain organized records of procedures, protocols, and results. * Compile and analyze data using appropriate statistical and analytical methods. * Assist in data interpretation and presentation, contributing to research findings and reports. Qualifications Education Bachelor's Degree Related Field of Study required Can this role accept experience in lieu of a degree? Yes Licenses and Credentials Experience Prior laboratory experience, either through academic coursework, internships, or employment 1-2 years preferred Knowledge, Skills and Abilities * Strong theoretical and practical knowledge of laboratory techniques and procedures. * Familiarity with common laboratory equipment and instruments used in research experiments. * Proficiency in data collection, analysis, and scientific software tools. * Excellent attention to detail, organizational skills, and the ability to multitask and prioritize tasks effectively. * Strong problem-solving skills and the ability to troubleshoot technical issues. * Excellent written and verbal communication skills to effectively convey experimental procedures, results, and challenges. Additional Job Details (if applicable) Remote Type Onsite Work Location 114 16th Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $19.76 - $28.44/Hourly Grade 5 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary GENERAL SUMMARY/ OVERVIEW STATEMENT Working independently under the general supervision, executes protocols involving variety of routine and non-routine, highly specialized experimental procedures. Participates in the design and modification of research protocols under Laboratory Director Supervision. Will be working with research animals (mice and rats), cell culture, as well as animal tissue and blood specimens. Composes and presents sections of research reports, manuscripts or grant application. Performs advanced data analyses using advanced statistical techniques. Coordinates laboratory activities and undertakes quality assurance programs. Will be responsible for orienting and training staff. Will be able to analyze results on her/his own. Technician reports directly to Laboratory Director. Qualifications PRINCIPAL DUTIES AND RESPONSIBILITIES Under the Supervision of Principal Investigator, designs and performs research laboratory experiments in the field of cardiovascular endocrinology, including: Animal studies using rodent (rats and mice) colonies, including blood pressure measurements by tail cuff and telemetry. Performs handling of rodents (e.g., mass, food consumption, urine collection) Preparation and maintenance of cell cultures. Preparation and analysis of DNA, RNA, and mRNA Isolation and analysis of proteins including electrophoresis, transfections, etc. Isolate and collect tissues relevant to the phenotype being studied (e.g. heart, kidneys, conductance/resistance arteries, adrenal glands, etc.). Separate Zona Glomerulosa and Zona Fasciculata cells from the collected adrenals, and perform adrenal cell stimulation experiments. Measure analytes in animal serum/plasma (e.g. hormones, cations, etc.) Record data, analyzes and summarizes results. Utilizes computer spread sheets and graphics to prepare data plots and figures. Prepares and maintain laboratory reagents, chemicals, instruments, and equipment. Maintain supplies and inventory, and maintain established departmental policies, procedures, objectives, quality assurance, safety, environmental and infection control. Assist in the training of new lab members. Discusses program, regularly with Principal Investigator. Performs other duties and responsibilities as directed. QUALIFICATIONS BS in biological/physical science. SKILLS/ ABILITIES/ COMPETENCIES REQUIRED Computer skills (intermediate level) including word processing and spreadsheet applications required. Must be extremely organized and capable of working under pressure. Must be proficient in basic laboratory procedures: Westerns, RT-PCR, immunoassays. Be flexible to adjust schedule in accordance with the needs of the department. Ability to identify potential or on-going problems and help develop solutions to such problems. Must have the ability to work independently. Must possess initiative. Must possess good interpersonal skills to interact courteously and effectively with co-workers, research investigators, other hospital personnel, and external contacts. Must be able to work with animals - rodents. Must show a desire to learn new techniques, disease-related approaches, etc. Experience performing surgeries in animals is a plus. WORKING CONDITIONS Normal laboratory environments. May have exposure to infection materials and hazardous substances, exposure to odors, exposure to noise, under controlled conditions. Possible visual strain and hand strain encountered while performing specimen-processing or while using computer terminals. Work requires frequent standing, walking and occasional lifting or carrying supplies. Additional Job Details (if applicable) Additional Job Description Remote Type Onsite Work Location 221 Longwood Avenue Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $19.76 - $28.44/Hourly Grade 5 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Summary: Carries out a broad range of technically advanced research activities and procedures; evaluates conclusions and has considerable latitude to modify or devise methods and techniques as necessary to achieve desired results; typically supervises technical and sometimes administrative elements of the research unit. Helps onboard new staff and train them in the lab. Essential Functions: Develop or have input into modifications of existing assay techniques, experimental protocols, or new procedures. * Synthesizes and interprets results. * Prepares written and/or verbal status reports. * Performs statistical analysis and makes recommendations. * Independently performs non-routine, highly specialized experimental procedures. * Composes and may present sections of research reports and manuscripts. Qualifications A laboratory research technician position is available in the lab of Dr. Steven Blum at the MGH Krantz Family Center for Cancer Research (KF-CCR). The Blum Lab aims to develop safer and more effective immunotherapy strategies for patients with solid tumors. Using patient samples, systems immunology approaches, and disease-relevant models, the lab will investigate the cellular and molecular drivers of treatment toxicity and resistance. Current efforts focus on two major challenges: 1. Understanding immune-related adverse events (ir AEs) and their relationship to anti-tumor immunity in patients receiving immune checkpoint inhibitors. 2. Investigating peritoneal metastases and malignant ascites, a common complication of advanced cancers associated with poor survival. Initial projects are particularly focused on patients with gastric and esophageal cancers. Our long-term goal is to uncover broadly applicable principles that inspire new therapeutic strategies and improve clinical care by maximizing anti-tumor immunity while minimizing harm. The Blum Lab is located in a state-of-the-art research building on the main MGH campus, surrounded by world-class investigators across multiple disciplines. The lab is affiliated with the MGH Department of Medicine, the MGH Cancer Center, Harvard Medical School, and the Broad Institute of MIT & Harvard, providing access to cutting-edge technologies and opportunities for collaboration across Boston's vibrant biomedical community. It is a demanding and fast-paced environment that requires hard work, attention to detail, and an ability to interact well with others as part of a cohesive group. The lab values teamwork, scientific rigor, and curiosity, and it is committed to providing a supportive training environment for motivated scientists. This position offers the opportunity to learn and employ systems immunology techniques, perform patient-derived ex vivo and in vitro functional assays, and apply single-cell genomics tools to address critical questions in human tumor immunology and autoimmunity. The role involves work in biosafety level 1, 2, and 2+ (BL1-BL2+) laboratory environments. Research technicians will be expected to work both independently and collaboratively with investigators, staff, clinicians, fellows, and students. Principal Duties and Responsibilities * Design and conduct bench-level experiments, in consultation with the Principal Investigator. * Lead small independent research projects. * Perform laboratory experiments, which may include the following (note: knowledge of all techniques is not required to apply): * Isolation and purification of primary cells from human and mouse samples * Flow cytometry and cell sorting * Cell culture for ex vivo and in vitro functional assays * Fluorescence microscopy and image analysis * Cellular perturbation using genetic and mRNA-based approaches * Single-cell RNA/DNA/protein/ATAC-sequencing and spatial transcriptomics * Molecular cloning * Molecular biology techniques (DNA/RNA isolation, PCR, qPCR, sequencing library prep) * Analyze experimental results, troubleshoot protocols, and suggest improvements. * Document, compile, and interpret experimental data; maintain accurate laboratory records of samples, cell lines, and reagents. * Operate, manage, and maintain complex lab equipment, including flow cytometers, fluorescence microscopes, and other instruments. * Participate in lab meetings and contribute to collaborative discussions. * Assist with general laboratory responsibilities, including inventory and coordination with vendors. * Other tasks as required. Requirements * Bachelor's degree in Biology, Biochemistry, Immunology, Molecular Biology, Life Science, Engineering, or a related field. * For applicants with a Bachelor's degree: >2 years of research experience preferred. * For applicants with a Master's degree: >1 year of directly related, full-time lab experience. * Proficiency in basic lab techniques. * Strong organizational skills, attention to detail, and reliability. * Ability to work independently and collaboratively in a team setting. * Excellent written and oral communication skills. * Flexibility to assist with processing occasional afternoon clinical samples. * Proficiency with computer software, including Microsoft Office (Word, Excel, PowerPoint) and web-based applications. Preferred (not required): * Familiarity with scientific databases and literature. * Prior project management experience. * Exposure to bioinformatics tools (e.g., Python, R) or programming languages (C/C++, Java). The Blum Lab welcomes talented applicants at all training levels and will tailor responsibilities to experience. This position provides an excellent opportunity to gain hands-on research experience in immuno-oncology within a highly collaborative environment. Education Bachelor's Degree Related Field of Study required Licenses and Credentials Experience Experience in an academic or laboratory research setting 1-2 years required Knowledge, Skills and Abilities * Excellent communication skills. * Good interpersonal skills and the ability to oversee the work of others. * Ability to work independently. * Ability to identify problems and develop solutions. * Ability to prioritize tasks and set deadlines. * Strong database management and overall computer skills. * Functions with speed, precision and an understanding of theory behind tests and procedures. Additional Job Details (if applicable) Remote Type Onsite Work Location 80 Blossom Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $49,504.00 - $72,404.80/Annual Grade 6 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary GENERAL SUMMARY/ OVERVIEW STATEMENT: The MGH Special Processing Laboratory (SPL) provides pre-analytical laboratory services involved in preparing research samples obtained from patients enrolled in clinical trials of investigational cancer treatments for storage and shipment. The primary responsibilities of this position involve processing samples according to specific written procedures for short term storage until packaged for shipment to external laboratories. Additionally, the position assumes the overall responsibility for managing the storage of samples received by the SPL and executing their shipment to other facilities such as external sponsors, contracted reference laboratories, and other research laboratories at MGH. PRINCIPAL DUTIES AND RESPONSIBILITIES: Sample Processing Responsibilities: - Processes biological samples (i.e., blood, urine, saliva, bone marrow aspirate, cerebrospinal fluid, etc.) for short term storage according to specific written procedures. - Properly follows all Universal Precautions and utilizes Engineering Controls, Work Practices, and Personal Protective Equipment (PPE) as listed in the laboratories Exposure Control Plan (ECP) and the MGH Biosafety Manual. - Completes required safety training annually and as required. - Ensures the accuracy and integrity of all data recorded to serve the mission of the SPL: - Enters all information for all samples submitted to the laboratory in a printed daily log form. - Transfer's data in the hard copy daily log form into an electronic sample receipt log. - Performs quality control on the hard copy/electronic sample log as required daily. - Transfer processed sample transport tubes into their designated locations in ultralow temperature freezers according to established standard operating procedures and freezer inventory logs. - Prepares and safely handles reagents used for processing biological samples for storage and shipment. - Properly follows all directives in the laboratory's Chemical Hygiene Plan (CHP). - Has knowledge of a chemical's labeling and information found in the material safety data sheet (MSDS). - Performs inventory check of all chemicals, consumables, and other supplies within the laboratory routinely and communicates the ordering needs of the laboratory to appropriate personnel. - Transports research samples from clinical patient treatment areas within the hospital to the laboratory for processing. - Requires walking to and from other areas of the hospital. - Represents the SPL in a positive and professional manner when interacting with both collegial healthcare providers, patients, and the public. - Performs routine maintenance and cleaning of laboratory equipment according to standard operating procedures. - Monitors acceptable performance of SPL equipment. - Troubleshoots equipment issues as necessary. - Communicates any equipment issues to the appropriate personnel. - Assists with packaging samples required tobe shipped from the SPL on the same day of collection (ambient, refrigerated, frozen). - Independently operates and works collaboratively with other laboratory personnel to effectively manage the daily activities of the SPL. - Monitors the SPL SharePoint Collection schedule and predicts/prepares requirements of scheduled protocol collections. - Processes research liquid biopsy collections in a timely and efficient manner. - Reviews and responds periodically to emails directed to the general shared email inbox of the SPL in a professional and timely manner. - Assists with or performs any other tasks as directed by senior staff in the laboratory. Sample Packaging/Shipping Responsibilities: - Prepares a daily sample shipment schedule from information obtained from the daily specimen receipt log, SPL SharePoint Collection Schedule, and received laboratory requisitions. - Prioritizes the shipment of samples required to be shipped on the day of collection or at other designated frequencies (weekly, bi-weekly, monthly, etc.). - Effectively shifts prioritization of shipments based on daily received samples, needs of the department, and inventory of supplies. - Works in collaboration with SPL laboratory personnel to expedite the shipping of samples requiring to be immediately shipped (ambient, refrigerated, frozen day of collection samples). - Prepares required documentation - Performs sample preparation - Performs packaging and labeling - Effectively delegates tasks to others in the department - Serves as a resource to delegate - Prepares packages containing processed biological samples according to all standard operating procedures and regulations (i.e., IATA, DOT). - Monitors received requisitions and sample receipt records to identify stored samples that can be shipped. - Initiate's shipments following standard operating procedures, protocol specific procedure files, shipping instruction files, and other documentation resources prepared and provided by the SPL. - Assembles all materials required for packages to be shipped: shipping container, airway bill, requisition form, packaging inventory and/or shipping manifest, dry ice, cold packs, etc. as stated in departments internal procedures and reference materials. - Notifies the recipient or sponsor contact in advance of an impending shipment as required (typically through email communications). - Maintains accurate electronic and hard copy records of all samples required to be shipped from the SPL freezers. - Records entries in the SPL Sample Receipt Log to record the date of shipment/transfer, the number of samples shipped/transferred, and any additional pertinent information. - Extract's shipping instructions for samples from reference documents for each clinical trial and creates a comprehensive Shipping Instruction file for each study. - Accurately prepares sample shipping manifests (and other required documents as needed) for shipping samples to recipients. - Reviews, updates, and electronically files shipping documentation (such as laboratory requisitions, shipping manifests, processing records, etc.) provided by clinical teams with the submission of samples to SPL and/or prepared by SPL. - Monitors sample inventory utilizing documentation and resources in the department (i.e., sample receipt log) to ensure that the proper chain of custody is maintained on all samples through storage, packaging, and shipping. - Corrects any sample storage issues immediately. - Effectively communicates knowledge of any missing samples to the leadership of the SPL. - Communicates in a professional and timely manner with responsible personnel (i.e., CCPO colleagues, sponsor contacts, receiving facilities) for the purposes of: - Securing the necessary shipping supplies/materials. - Sending notifications of shipments to stakeholders. - Requesting any needed clarification for encountered issues. - Assisting with any queries from internal and external stakeholders related to shipping documentation. - Performs temperature monitoring, as needed troubleshooting, and required preventative maintenance of the SPL's Cold Storage Units. - Knowledgeable of the department's Temperature Monitoring of Cold Storage Units standard operating procedure and serves as a resource on the department's critical alert system call tree. - Responds to temperature issues timely and appropriately documenting the steps taken to ensure the integrity of all samples. - Escalates temperature monitoring issues to the leadership of the SPL. Contacts service if necessary, according to departments standard operating procedures. - If required, reports to campus to assist with the transfer of samples from a non-functional freezer to an operating freezer. - Monitors the inventory of the laboratories dry ice supply. - Manages orders from primary and secondary suppliers as needed. - Transfers dry ice from vendor supplied boxes to central dry ice box supplies (requires lifting boxes up to 50 pounds). - Transports packages to the MGH Mail Room for courier service pick up. - Requires walking to and from other areas of the hospital. - Requires lifting packages that are light to moderately heavy. - Assist with or perform any other tasks as directed by senior SPL staff. Qualifications EDUCATION: - Bachelor's degree in a physical or biomedical science is required. EXPERIENCE: - New graduates with some lab experience (via course work, internships, etc.) or those without any prior research experience will be considered for the Research Technician I position outlined above. - Those with a minimum of 1 year of directly related work experience will be considered for a Research Technician II position. SUPERVISORY RESPONSIBILITY (if applicable): not applicable Additional Job Details (if applicable) Additional Job Description Remote Type Onsite Work Location 123 Main Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Rotating (United States of America) Pay Range $23.80 - $34.81/Hourly Grade 6 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Under the direction of the Principal Investigator the Research Technician will provide laboratory and clinical translational research assistance for optical imaging methods in a variety of settings (healthy volunteers, cardiac surgery patients, neurocritical care, cardiovascular care, breast imaging, etc…) led by the MGH Martinos Center Optics Division. The position is based at the Martinos Center at the MGH Charlestown Navy Yard campus, under the supervision of Dr. Stefan Carp. Job Summary The position will offer an opportunity to participate in cutting edge research in optical and multi-modal imaging in collaboration with a multi-disciplinary team of investigators at the Martinos Center and in several clinical departments within the hospital. The RT will work independently under the general direction of the PI to coordinate research studies and assist in data analysis and research reporting.The position will involve: performing laboratory-based measurements for instrument validation and testing, performing measurements on human subjects and occasionally on animal models, performing data analysis, and assisting in the recruitment of subjects and in the preparation and maintenance of human subject research (IRB) protocols and associated documentations. The RT will also have an opportunity to help the PI and other members of the team with developing new data processing and analysis methods. Occasionally the human subject measurements will need to performed after hours and on the weekends (some of the intensive care studies rely on recruiting patients as soon as possible after admission and cannot be planned ahead of time). Qualifications Education Bachelor's Degree Related Field of Study required Experience Prior laboratory experience, either through academic coursework, internships, or employment 1-2 years preferred PRINCIPAL DUTIES AND RESPONSIBILITIES: * Assist in the execution of human subject measurements in both a laboratory and clinical setting * Assist in the building and testing of novel research instruments * Conduct data analysis and processing using a variety of processing tools, generally implemented in the MATLAB environment (Python is also acceptable) * Co-ordinate recruitment and clinical measurements in conjunction with clinical collaborators. This includes communicating with study subjects. * Maintain research data, patient files, regulatory binders and study databases * Prepare reports and presentations * Participate in preparing manuscripts for publication. * Prepare IRB submissions and amendments and help maintaining documentation for the IRB * Collecting and maintain subject information database * Proof-reading and editing of manuscripts and grant applications SKILLS & COMPETENCIES REQUIRED: * Prior programming experience is required, prior experience with MATLAB is a plus; note that a data analysis exercise in Matlab or another language of the candidate's choice will be included as part of the interview process * An engineering or physical science background is strongly preferred * Knowledge of electro optical systems and/or biomedical optics is a plus * Ability to make independent effective decisions * The ability to work as part of an integrated research team * Excellent judgment and ability to interpret information and protocol requirements * Excellent organizational, oral and written communication skills * Detail oriented, creative, able to maintain accurate records * High degree of professionalism, ability to interact with study subject and clinical collaborators * Capable of handling confidential information with discretion * Ability to make independent effective decisions Additional Job Details (if applicable) Remote Type Onsite Work Location 149 Thirteenth Street Building 149 Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $19.76 - $28.44/Hourly Grade 5 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary A full-time Research Technician position is available at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, under the supervision of Dr. Anastasia Yendiki. The technician will join the investigative team of the Large-Scale Imaging of Neural Circuits (LINC) project, and as such contribute to an unprecedented effort by the NIH BRAIN Initiative to produce first-ever maps of brain connections across scales (******************************************************************************************************************************************************************* The LINC project brings together a multi-disciplinary group of experts from 8 institutions (Brigham and Women's Hospital, Columbia University, Harvard University, Massachusetts General Hospital, Massachusetts Institute of Technology, University College London, University of Rochester, Weill Cornell Medicine) to develop novel imaging technologies and combine them with machine learning to produce detailed wiring diagrams of the brain (********************************** The technician will assist with this effort by collecting and analyzing ex vivo MRI and optical microscopy images. The position offers the opportunity to participate in publications and to be part of a fast-paced research environment at the cutting edge of neuroimaging method development. Qualifications Education Bachelor's Degree Related Field of Study required Can this role accept experience in lieu of a degree? Yes PRINCIPAL DUTIES AND RESPONSIBILITIES: * Write, test, and troubleshoot computer code to contribute to the development of custom software tools for image analysis and visualization * Handle and prepare post mortem brain samples for imaging * Perform and troubleshoot MRI and/or optical imaging scans of post mortem brain samples * Assist with quality assurance, pre-processing, and annotation of imaging data * Assist with maintaining lab documentation and software repositories SKILLS & COMPETENCIES REQUIRED: * Strong mathematical skills, as evidenced by relevant coursework. The ideal candidate will have a degree in engineering, applied math, computer science, or related field, and an interest in learning about neuroscience and imaging. * Excellent organizational skills, oral and written communication skills. * High comfort level with computers. * Ability to work independently as well as within an integrated research team. * Ability to prioritize multiple tasks and handle fluctuating priorities and deadlines. * A high degree of professionalism and attention to detail. EXPERIENCE: Required: Some prior research experience, in a computer lab or wet lab setting. Preferred: Prior experience in data acquisition or analysis for MRI or optical imaging is desirable but not required. WORKING CONDITIONS: The position involves working in MRI or optical imaging facilities with fixed post mortem brains, as well as working in a computer lab. Flexibility to perform or monitor data acquisition on evenings or weekends, depending on scheduling constraints of the respective imaging facilities, is required. Additional Job Details (if applicable) Remote Type Onsite Work Location 149 Thirteenth Street Building 149 Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $19.76 - $28.44/Hourly Grade 5 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. We are looking for a full-time research assistant to perform laboratory experiments at Massachusetts General Hospital and Harvard Medical School in the Laboratory of Jonathan Green (********************************** preferably for 1-2 years. The aim of the project is to understand how neuron types in the cerebral cortex contribute to learning. Responsibilities Perform behavioral and brain imaging experiments on mice. Qualifications Experience working with rodents in a research laboratory is strongly preferred. Experience working in a neuroscience lab and on rodent behavior is ideal. Critical skills include attentiveness to detail, excellent organization and notetaking. Job Summary Summary This role is designed for candidates who plan to pursue advanced graduate studies (e.g., a Ph.D. or M.D.) and offers an opportunity to engage in rigorous research projects under the mentorship of leading scholars. The position provides hands-on experience in research methodologies, data analysis, and academic writing, making it an excellent stepping-stone for future educational and research careers. Does this position require Ability to work objectively and collaboratively within a team environment. * Collaborate on research projects, contributing to study design, data collection, and analysis. * Conduct systematic literature reviews to summarize existing research in the field. * Develop and maintain datasets for research purposes. * Perform statistical, quantitative, and/or computational analyses. * Organize, attend and effectively participate in team meetings, workshops, and seminars. * Assist in the preparation of teaching or training materials as needed. * Draft, edit, and contribute to research publications, presentations, and grant proposals. Qualifications Education Bachelor's Degree Related Field of Study required and Master's Degree Related Field of Study preferred Can this role accept experience in lieu of a degree? No Licenses and Credentials Experience Previous Research Lab Experience 0-1 year preferred or Research Related Experience 0-1 year preferred or New grad with some relevant coursework 0-1 year preferred or Experience in a clinical or hospital setting 0-1 year preferred Knowledge, Skills and Abilities - Proficient time-management and organizational skills. - Good interpersonal and communication skills. - Knowledge of clinical research protocols. - Must possess proficient analytical skills. - Proficient in critical thinking and data analysis abilities. - Desire to work both objectively and lead within a team unit. - Commitment to ethical standards in research and patient care. - Proficient in database management and computer skills. - Proven ability to collaborate across disciplines and lead research teams. - Excellent judgment and ability to interpret information and protocol. Additional Job Details (if applicable) Remote Type Onsite Work Location 185 Cambridge Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

This is an opportunity to join Ordovas-Montanes Lab, which specializes in understanding how inflammation drives memory formation in barrier tissues with the goal of developing new therapeutic avenues for human disease. This candidate will contribute to a collaborative project focused on mucosal immunity to respiratory infection and vaccination. The candidate will work under the direct supervision of Dr. Jose Ordovas-Montanes and be closely integrated within a community of senior scientists, graduate students, and postdoctoral fellows. This position requires substantial technical expertise, the ability to troubleshoot specialized assays, and the capacity to support and train junior lab members as needed. This role offers the opportunity to develop a wide range of experimental and computational skills while working in an interdisciplinary environment with access to resources across Boston Children's Hospital and Harvard Medical School. The ideal candidate is motivated to understand the biological principles underlying infection-induced inflammatory diseases and may be interested in pursuing future postgraduate education. Key Responsibilities: * Independently perform complex experimental workflows, help optimize protocols, and generate high-quality data for single-cell genomics and airway epithelial biology studies. * Troubleshoot specialized assays. * Support and train junior lab members as needed. * Performs routine and highly specialized lab experiments using sophisticated and intricate research equipment and techniques. Performs and devises specialized experiments and research procedures, troubleshooting problems with own and other researchers' results. * Assists other lab personnel with the use of specialized equipment and techniques within the lab. Minimum Qualifications Education: * Bachelor's degree in biology, immunology, genomics, chemistry, or a related field is required. Master's degree preferred but not required. Experience: * Bachelor's and 4 years of relevant experience OR a Master's of Science and 2 years of relevant experience. * Demonstrated experience performing mammalian cell culture, ideally primary airway epithelial culture or similar complex systems. * Proficiency in molecular biology techniques. * Proven ability to independently execute and troubleshoot complex laboratory workflows. * Experience with single-cell RNA-sequencing methods and data analysis in R and/or python is preferred but not required. The posted pay range is Boston Children's reasonable and good-faith expectation for this pay at the time of posting. Any base pay offer provided depends on skills, experience, education, certifications, and a variety of other job-related factors. Base pay is one part of a comprehensive benefits package that includes flexible schedules, affordable health, vision and dental insurance, child care and student loan subsidies, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition and certain License and Certification Reimbursement, cell phone plan discounts and discounted rates on T-passes. Experience the benefits of passion and teamwork.

A RESEARCH TECHNICIAN position is available in the laboratory of Dr. Yana Pikman (*********************************** at the Dana-Farber Cancer Institute. Our research focuses on the application of clinical genomics for development of targeted therapy approaches for acute leukemia, drug testing and combination screening with the ultimate goals of 1) improving understanding of leukemia biology and 2) translating bench discovery to clinical care. You will join a team of investigators leading these efforts in the academic environment, working at the bench, collaborating closely with scientists as well as clinical researchers. You will play an essential, and possibly leading, role in project-focused work. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. Responsibilities * Conduct bench level experiments to support the goals of scientific research in leukemia and genomics * Maintain cell lines and isolate primary cells for use in cell based assays * Performing a variety of basic cancer biology assays, including in vitro proliferation or apoptosis assays, drug sensitivity assays, flow cytometry and western blotting, in vivo xenograft experiments * Performing a variety of molecular biology assays- cloning, PCR, DNA/RNA isolation * Lentiviral transduction techniques for ORF-overexpression experiments or CRISPR-Cas9 knockdown/knockout experiments * Operate and maintain laboratory equipment to complete investigations * Prepare, order, and maintain stocks of necessary reagents, solutions and supplies * Document, compile, and analyze experimental data. Troubleshoot and solve scientific problems with supervision * Report data in oral and written formats * Monitors laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory. * Expected to provide intellectual and interactive commitment to position by keeping up with appropriate literature and research publications. * May be responsible for designing and executing advanced experiments and setting strategy. * Participate in team meetings for experimental planning, discussion of projects and general learning * Participate in research meetings at the DFCI and Boston Children's Hospital Qualifications * Bachelor's degree in Biology or related field required, or equivalent combination of education and experience * 1-2 years prior laboratory experience is strongly desired but not absolutely required. More experienced applicants who have worked for multiple years as a professional scientist or research technician are also encouraged to apply and would be considered at an appropriate level of compensation and benefits. * A history of hard work and sound academic achievement is required. * Familiarity with basic laboratory techniques and principles of molecular biology * Experience working in a medical or scientific research setting or comparable technology-oriented business environment * Knowledge of computers and experience with databases * Ability to analyze information and use logical reasoning to address work-related issues and problems. * Ability to work within a team environment. * Must have attention to detail and be thorough in completing work tasks. * Excellent written and oral communication skills * Strong organizational skills, including the ability to handle a variety of tasks in a fast-paced environment required * We are looking for candidates with a minimum of two years of availability. Candidates with laboratory technician experience and those potentially interested in a long term position are encouraged to apply. Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $47,500 - $51,300 APPLY: Please apply on our careers page. You can e-mail a cover letter/letter of interest to: Yana Pikman, MD Principal Investigator Yana_*********************** At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

The Research Technician will assist scientists in performing scientific research, development and/or clinical tasks of varying complexity. In general, they will assist in the set up, operation and maintenance of laboratory instruments and equipment, monitoring experiments, making observations and calculating and recording results. The D'Andrea Lab investigates the mechanisms underlying chromosome instability and cancer susceptibility. Our research focuses on the molecular signaling pathways that regulate the DNA damage response in mammalian cells. Disruption of these pathways-whether through germline or somatic mutations-can lead to genomic instability, sensitivity to ionizing radiation, and defects in cell cycle checkpoints and DNA repair. Such alterations are frequently observed in cancer and contribute to increased mutation rates and tumor progression. The lab employs a wide range of innovative technologies to measure DNA damage responses in cancer cell lines, including cytotoxicity assays and proteomic biomarker analyses. The Research Technician will support postdoctoral fellows and scientists in conducting experiments of varying complexity. Responsibilities include assisting with the setup, operation, and maintenance of laboratory equipment; monitoring experiments; collecting and analyzing data; and maintaining accurate records. Technicians will develop strong critical-thinking skills and gain experience in designing rigorous, well-controlled experiments. There will also be opportunities to contribute to scientific publications as a co-author. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. Responsibilities * Clean, maintain, and prepare laboratory work areas and supplies * Assist with inventory management and ordering reagents. * Ensure compliance with laboratory safety protocols and institutional Environmental Health and Safety (EHS) guidelines. * Maintain a detailed and organized laboratory notebook documenting all experimental procedures, observations, and results. * Culture, expand, and cryopreserve a variety of cancer cell lines under sterile conditions. * Design, optimize, and perform cell-based assays to investigate target biology and evaluate experimental hypotheses. * Participate in lab meetings, group discussions, and institute-wide seminars with invited speakers. * Ensure adherence to Environmental Health and Safety guidelines and laboratory-specific standard operating procedures; monitor compliance and promote safe laboratory practices. Qualifications * Minimum Bachelor's / Master's degree required with a major in biology or chemistry. * Knowledge of information and techniques related to either biology, chemistry, or medicine is preferred. * Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff. * Ability to analyze information and use logic to address work-related issues and problems. * Must have attention to detail and be thorough in completing work tasks. * Ability to work within a team environment. * Some computational biology experience is a plus. Pay Transparency Statement The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $47,500 - $51,300 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. EEOC Poster

The Computational Neuroscience Laboratory, led by Dr. Caterina Stamoulis, is seeking a highly motivated, full-time Research Assistant I/II. The Research Assistant will work on projects at the intersection of Computational Neuroscience and Data Science, which aim to analyze large functional and diffusion MRI (fMRI and dMRI) datasets with the goal of understanding the development of brain circuits in adolescence and the impact of physiological and environmental factors on their maturation trajectories. This is an excellent opportunity to work at a teaching hospital of Harvard Medical School, become involved in Computational Neuroscience research, and learn cutting-edge computational techniques. Key Responsibilities: * Independently develop large-scale computer codes, almost exclusively using the software MATLAB, and implement novel algorithms for characterizing brain networks and their developmental trajectories. * Analyze large volumes of fMRI, structural MRI and diffusion MRI data. * Develop statistical models for longitudinal analyses. * Maintain and expand the capabilities of a novel computational platform for large-scale analysis of very large brain datasets. * Participate as co-author in manuscripts and conference abstracts. Minimum Qualifications Education: * Bachelor of Science in degree in Neuroscience, Biological/Biomedical Engineering, Electrical Engineering (with a focus on Signal Processing) or Physics. * Coursework in computational Neuroscience (if pursuing a degree in Neuroscience). * If not a Neuroscience graduate, basic coursework in Neuroscience. Experience: * Experience in MATLAB programming and ability to independently write codes is required. * At least 1 year of research experience. * Experience in analysis of human brain data is heavily preferred. * Experience in fMRI data processing is preferred. The posted pay range is Boston Children's reasonable and good-faith expectation for this pay at the time of posting. Any base pay offer provided depends on skills, experience, education, certifications, and a variety of other job-related factors. Base pay is one part of a comprehensive benefits package that includes flexible schedules, affordable health, vision and dental insurance, child care and student loan subsidies, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition and certain License and Certification Reimbursement, cell phone plan discounts and discounted rates on T-passes. Experience the benefits of passion and teamwork.

This Research Assistant will assist in the design, performance and analysis of experiments to investigate the molecular biology, pathogenesis and immunology of Streptococcus pneumoniae, focusing on regulation of gene expression, immune responses and protection against disease. The position involves the use of microbiological, molecular biological and biochemical techniques and requires a basic knowledge in these fields. The position will also have the responsibility to maintain and order reagents, stocks and supplies. This person will meet regularly with the principal investigator to discuss research plans and results. Key Responsibilities: * According to prescribed protocols and assigned schedules, performs a variety of routine laboratory experiments and procedures, utilizing standard laboratory equipment, recording and checking results for completeness and accuracy. * Assists in troubleshooting procedures if experimental results are unexpected or quality of specimens is poor. * Performs the following techniques typically required for the laboratory/study: * Maintains records of results and methodologies in a log of work performed. * Maintains equipment, lab area, and supplies in a neat professional manner. * Sterilize and clean glassware, and prepare media and other materials using appropriate procedures. * Inventories supplies, alerts supervisor to needed supplies, or mixes standard reagents. * Processes order for supplies and/or animals. Attends courses in safety procedures for handling, storage, and disposal of biohazardous, flammable, corrosive, and toxic materials. * Carries out all laboratory activities in compliance with applicable regulations and protocols. * Conducts literature searches and reviews, compiling information for journals and suggesting uses for new techniques to the P.I. Minimum Qualifications Education: * A Bachelor's degree in Biology or a related field is required. The posted pay range is Boston Children's reasonable and good-faith expectation for this pay at the time of posting. Any base pay offer provided depends on skills, experience, education, certifications, and a variety of other job-related factors. Base pay is one part of a comprehensive benefits package that includes flexible schedules, affordable health, vision and dental insurance, child care and student loan subsidies, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition and certain License and Certification Reimbursement, cell phone plan discounts and discounted rates on T-passes. Experience the benefits of passion and teamwork.

The research technician role will assist scientists in performing scientific research, development and/or clinical tasks of varying complexity. In general, they will assist in the set up, operation and maintenance of laboratory instruments and equipment, monitoring experiments, making observations and calculating and recording results. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. + Set up, adjust, calibrate, clean, maintain and troubleshoot equipment. + Conduct standardized biological, microbiological or biochemical tests and laboratory analyses, including the collection of information and samples from organic substances. + Isolate, identify and prepare specimens for examination. + Analyze experimental data and interpret results to write reports and summaries of findings, including grant preparation and presentations, and look for opportunities to co-author publications. May be expected to participate in formal and information presentations of results to staff. + Maintains detailed notebook of all work-related activities. + Monitors laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory. + Expected to provide intellectual and interactive commitment to position by keeping up with appropriate literature and research publications. + May be responsible for the development, modification and improvement of standard operating procedures. + Performs standard experimental procedures as assigned (i.e. - pipetting, cell and tissue culture, PCR, etc.) + Executes and troubleshoots genomic and proteomic assays as well as gene editing protocols, including, long-read sequencing, CRISPR-Cas9 editing and other specialized protocols. + Maintains lab reagents, chemicals and sample database. + Sets up and prepares routine experiments as directed. + Conducts analysis and interpretation of observed results. + Bachelor's Degree required with a major in biology or chemistry preferred. + Knowledge of information and techniques related to either biology, chemistry, or medicine is preferred. + Ability to analyze information and use logic to address work-related issues and problems. + Must have attention to detail and be thorough in completing work tasks. + Strong communication and interpersonal skills with ability to work within a team environment. + Highly organized in record-keeping + Prior research experience in related area (beyond a classroom setting) + Prior experience programming in R or Python or interest in learning basic programming is a plus **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $47,500 - $51,300 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**

The Targeted Protein Degradation (TPD) Proteomics Core within the Fischer Lab at Dana-Farber Cancer Institute serves as a resource for the Cancer Biology Department, aiding investigators in answering key research questions using mass spectrometry-based proteomics. We employ quantitative chemoproteomic and interactomic approaches to identify drug targets and are continuing to expand our repertoire to meet the needs of our core users. Our core is equipped with extensive mass spectrometry equipment including tims TOF HT, tims TOF Ultra2 and Orbitrap Eclipse tribrid mass spectrometers. The TPD Proteomics Core seeks a highly motivated individual to join the team as a at Dana-Farber Cancer Institute is seeking an experienced RESEARCH TECHNICIAN, who will employ mass spectrometry-based technologies to assess the cellular proteome in response to external stimuli. This individual will be an important member of our core team and will work with technicians, scientists, postdocs and students on a variety of different research projects focused on targeted protein degradation as a novel therapeutic modality. + Mammalian cell line management and ability to perform drug treatments and prepare samples from tissues and cells + Prepares lab reagents and media + Performs mass spectrometry sample preparation + Operation and maintenance of standard lab equipment including HPLC's, mass spectrometers + Analyzes experimental data and interpret results to write reports, presentations, grant and publication preparation + Maintains detailed notebook of all work-related activities + Maintains and orders laboratory supplies + Communicates with purchasing and may be responsible for negotiating with vendors + Collaborates with other lab members for the development, modification and improvement of standard operating procedures Bachelor's Degree required with a major in biology or chemistry preferred + A knowledge of information and techniques related to biology, chemistry or medicine is preferred + Understanding of statistical and computational methods is desirable + Must have close attention to detail and consistent work habits + Must have good time management + Ability to work in a collaborative and team environment + Excellent oral and written capabilities + Experience with R, MATLAB, or python and general computational abilities is preferred **Pay Transparency Statement** The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate's relevant experience, skills and qualifications. For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA) $47,500 - $51,300 At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law. **EEOC Poster**