Editas Medicine jobs

At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. Why Choose Editas? At Editas Medicine, we're a team of passionate problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what's possible in medicine, come join us and become an Editor! Decoding The Role: Editas Medicine is seeking a highly accomplished and experienced toxicologist, and a seasoned leader to join our DMPK, Nonclinical Safety and Translational Sciences (DSTS) team. In this leadership role, you will serve as the Head of Toxicology within Editas and be responsible for overseeing all nonclinical safety assessment related activities in rodent and non-rodent models. The successful candidate will apply their knowledge, expertise and drug development experience to advance our gene editing pipeline. The responsibilities include developing and implementing comprehensive strategies to fully integrate with the programs team objectives at all stages of development. The ideal candidate will have strong technical skills, a broad understanding of drug discovery and development, strong foundational knowledge and ability to work collaboratively with key partners in a matrix team structure. The individual in this role should be an independent thinker, collaborative, possess team-player mindset, and ability to thrive in a fast-paced environment. Prior experience with lipid nanoparticle based (LNP) delivery systems and/or gene editing products is a plus. The individual in this critical role will be an integral part of the nonclinical leadership team and will have the opportunity to help build the department to meet the business needs and to bring life changing therapies to patients with genetic disorders. Characterizing Your Impact: As the Director, Toxicology you will: * Develop phase-appropriate nonclinical safety strategies and execution to support Editas' pipeline. * Lead the design and oversee execution of GLP and non-GLP toxicology studies to support regulatory submissions and interactions with health authorities, including the authoring of nonclinical safety sections of US and international regulatory applications * Manage CRO relationships and collaborate with the internal team to drive CRO selection, study monitoring and reporting to ensure scientific rigor, meeting timelines, budgets, and regulatory compliance * Deliver high-quality safety reports to support clinical plans and regulatory filing submissions in multiple markets * Serve as the toxicology and/or nonclinical representative (provide subject matter expertise) in cross-functional meetings both internally and externally The Ideal Transcript: To thrive in this role, you'll need: * PhD in toxicology, pharmacology or related field (preference for DABT certified) with 10+ years of industry experience * Core expertise in toxicology with emphasis on general toxicology, genotoxicity, developmental and reproductive toxicology * Track record of advancing programs through nonclinical development including managing GLP and non-GLP studies, and regulatory submissions * Familiarity with FDA/EMA/ICH guidelines and proven track record of successful health authority interactions * Experience with gene editing or gene delivery technologies and lipid nanoparticle delivery is highly desired * Preference will be given to candidates who demonstrate deep interest in translational toxicology * Outstanding communication skills, both written and oral, and an ability to constantly adapt in a fast-paced dynamic biotech environment * Desirable personal attributes include strong organization skills, positive attitude, highly collaborative mindset and attention to detail. Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy. Salary Range: $220,000 - $240,000 Pay Transparency Editas Medicine is committed to transparency and accuracy in our hiring practices. The anticipated salary range for each position is posted within the role. The final salary offer will be determined based on a comprehensive assessment of the candidate's qualifications, including education, training, and relevant experience. Additional factors such as external market conditions, the role's criticality, and internal equity will also be considered. Editas Medicine's compensation philosophy ensures fair and equitable pay practices. Aspire to be an Editor? We invite you to apply and join us at the forefront of innovation and be a key contributor to realizing Editas Medicine's mission of developing transformative medicines for people living with serious diseases.

The Senior Meetings & Events Planner will be responsible for delivering strategic meeting planning for a variety of meetings independently and with the support of preferred logistics vendors. This role will be skilled in ensuring seamless execution of highly complex events while fostering strong relationships with global teams and suppliers. The ideal candidate will demonstrate problem-solving and interpersonal skills with a global point of view, and partner with cross-functional planning teams to ensure meeting logistics and planned activities are aligned and support the overall meeting goals and objectives. The ideal candidate must possess strong HCP/Compliance knowledge and experience and the ability to act as a solid meetings management resource both internally and externally. Key Duties & Responsibilities * Provides strategic guidance support and management to preferred logistics agencies on an event-by-event basis. * Strong project management skills managing multiple projects, vendors, and processes. * Consult and navigate cross-functional planning teams, vendors, and Business Owners through complex logistical planning by setting roles & responsibilities, adherence to HCP compliance and transfer of value, meeting best practices and strategy, and expectation of deliverables. * Demonstrated ability to build and manage complex budgets and guide vendors to manage multiple budgets with different timelines and deliverables. * Identify and resolve day-to-day matters related to project requirements, cross-functional processes, and vendor management operations. * Build and maintain strong partnerships with Business Owners and consult on meeting goals & objectives to provide strategic support solutions. * Ability to strategically engage and advise Business Owners across diverse meeting formats and therapeutic areas * Must possess ability to manage, communicate and interact with various of levels of internal business owners in professional and knowledgeable manner at all times * Strong adherence to internal & HCP compliance, transparency rules and reporting, knowledge and understanding of GDPR requirements. * Ability to travel domestically and globally at least 30% of the time. Required Education Level * Bachelor's Degree Required Experience * 5+ years of global meeting & event planning experience * Previous Pharmaceutical Experience a plus * Supplier/Vendor management experience a plus Required Knowledge/Skills * Proficient and professional meeting planning experience in a corporate setting. * Strong organization and time management skills, ability to simultaneously keep multiple projects prioritized and moving with multiple stakeholders. * Experienced contract negotiations skills with in-depth understanding of hotel and venue legal and business terms. Ability to guide negotiations of venue and vendors contracts, securing the best possible terms to provide Vertex with the most flexibility, financial security and cost saving opportunities. * Strong verbal and written communication skills, comfortable in group and individual presentations across all levels of the organization. * Strong knowledge of HCP Compliance regulations and ability to apply critical thinking to identify and escalate compliance risks to the Office of Business Integrity & Ethics while adhering to and implementing guidelines and monitoring team adherence. * Committed to delivering the highest level of customer service. * Flexibility and ability to successfully navigate ambiguity and succeed in a rapidly changing, fast-paced, deadline-driven environment with multiple priorities. * A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society. Other Requirements * Proficient in Microsoft Office suite. * Prior working knowledge of Cvent Event Management software program preferred. * CMP and or CMM Certification (a plus but not required) #LI-hybrid #LI-TC1 Pay Range: $91,200 - $136,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Commercial Data Management Associate Director serves as the Lead for the Global Healthcare Entity Master (GHEM), Data Management and Quality, Ad Hoc and Recurrent Analytics, and Field Performance Measurement and Reporting across our disease areas. Key Duties and Responsibilities: * Acts as an advisor and coach for and collaborates with the governance team(s) * Maintains data governance standards, policies, and procedures * Monitors data quality scorecards * Manages data services vendors * Trains internal teams on processes and procedures, including the CRM application * Collaborates with Global Information Systems (GIS) team regarding implementation of fixes and enhancements * Partners with Sales and Marketing teams to manage and administer content update requests * Manages HCP-to-Center affiliations and master data attributes * Create reports and dashboards * Manages the mobile analytics application * Manages the commercial data warehouse (CDW) - vendor communication, business rules and data sources * Manages data aggregation vendor - communication, business rules, and data sources * Manages patient transaction master data file * Monitors data supplier quality - accuracy, timeliness and completeness * Reviews data quality scorecards in collaboration with Trade team partners * Coordinates sourcing of commercial data - enforces "single version of truth" * Partners with Forecasting & Analytics team to deliver weekly performance content to commercial leadership team * Responds to ad hoc data inquiries from internal stakeholders * Manages mobile iPad sales performance application * Coordinates delivery of reports to Sales and Marketing teams * Responds to field inquiries and investigations * Trains field force teams on reports and business acumen regarding analytics * Creates HCP and treatment center segmentation * Ensures data accuracy and completeness * Owns data library and data governance standards, policies, and procedures * Data library and governance ownership Knowledge and Skills: * Experience with data vendors, external customers, and field teams * Extensive knowledge of master data management (MDM) processes * Strong familiarity with CRM, especially Salesforce and Veeva * Significant experience with query tools (MicroStrategy, Tableau, Excel) against a database to analyze data quality and content * Knowledge of data warehouse architecture, data modeling, and data integration techniques on platforms such as Oracle, Snowflake, Databricks * Experience with data vendors, external customers, and field teams * Proficiency in Microsoft Office (Word, Excel, Access, PowerPoint * Strong analytical, problem solving, and communication skills including ability to communicate effectively across all levels of the organization Education and Experience: * Bachelor's Degree required * Typically requires 6-8 years of direct experience with pharmaceutical data; sourcing, integration, analysis, and reporting Pay Range: $151,300 - $227,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Executive Medical Director, Patient Safety/Head Medical Safety and Risk Management will oversee all safety and benefit-risk related activities of the GPS Physician (Disease-area Safety Heads, DST Chairs) and the Aggregate Report Risk Management (ARRM) Groups within the Vertex Global Patient Safety (GPS) Department. As a member of the GPS Senior Leadership Team, the role will contribute to ensuring consistency and compliance in the safety assessment, analysis and reporting for all designated product(s) throughout Vertex's world markets. Overseeing the GPS DASH/DST teams across therapeutic areas, the role will ensure consistent conduct and timely execution of Benefit-Risk activities by GPS DASH/DST teams, including pre-marketing risk assessment, planning for First-In-Human (FIH) studies, safety content of key Modules (SCS, CLO, Labelling) in regulatory authority submissions for approval, including planning, content and execution of Risk Management Plans (RMPs) and/or Risk Evaluation and Mitigation Strategies (REMS) for and post-marketing requirements. The role will work closely with leaders from cross-functional teams on the successful achievement of key strategic activities, initiatives and deliverables. Key Duties and Responsibilities: * Provides leadership and oversight of DASH/Disease-area Safety Team(s) (DST) conduct, for all products across the Vertex Portfolio, including pre-FIH activities, key benefit-risk assessment, and providing strategy for DSTs to meet goals and objectives. * Coordinates and oversees the consistent and timely review of safety data for identification of new safety signals, in accordance with Vertex signal detection practices. * Collaborates with Clinical Leaders to develop and implement appropriate Risk Management procedures/plans for each product, both pre-approval and post-approval, as needed. * Collaborates with NDA teams assessment, strategy and execution of key Regulatory Authority documents in support of submissions, specifically leading safety content of key Modules (SCS, CLO, Labelling) and development of any Risk Evaluation and Mitigation Strategy (REMS), Risk Management Plan (RMP) or equivalent documents. * Collaborates with GPS Epidemiology with regards to development, implementation and reporting of pharmacoepidemiology studies, as needed. * Reviews and/or assists in preparation of Developmental and/or Post-Marketing Periodic Safety Updates (DSURs, PSURs/PBRERs), IND packages, as well as NDA and INDs. * Provides review and safety-specific input for labeling documents, including IB, CCDS, USPI, SmPC and other local labels, as applicable. * Collaborates with Regulatory Affairs to develop responses to any safety related regulatory agency inquiries. * Provides and oversees medical review of aggregate and/or individual post-marketing and clinical trial adverse event reports, in accordance with GPS review practices. * Oversees medical evaluation of other relevant non-AE/SAE related safety information, such as from Toxicology, Non-Clinical studies and Product Quality sources. * Reviews and provides oversight for medical content for key study-related documents, e.g., Protocols, Statistical Analysis Plan, IB, ICF and IDMC Charter. * Reviews and provides oversight in the analysis of safety data from on-going and completed clinical trials and representation in Clinical Study Reports. * Reviews and provides oversight of safety sections of clinical study reports. * Provides a contributory role in Partner /Affiliate agreements and interactions, as needed. * Serves as Subject Matter Expert in departmental development activities including SOP and Work Instructions development. * Leads Medical staff and liaise with Operations leads regarding optimal practice regarding collection, evaluation and processing of adverse experience reports, from a medical perspective. * Leads and guides direct reports, regarding the scope of DASH/DST Chair Physician responsibilities, and the provision of sound medical input for all pre-marketing and post-marketing activities. * Facilitates the growth and development of staff and direct reports. Knowledge and Skills: * Extensive knowledge of GCP, ICH and Global regulations. * In-depth and comprehensive knowledge of General Medicine. * Strong leadership skills with the ability to communicate effectively in a matrix environment. * Experience in the critical evaluation and interpretation of data, with ability to synthesize into clear, coherent messaging. * Extensive knowledge of Benefit-Risk strategies and decision-making. * Ability to multi-task, adeptly handling multiple demands. Education and Experience: * MD, DO or equivalent ex-US medical degree * 12+ years of work experience with experience in Pharmacovigilance and 7 years of supervisory/management experience, or the equivalent combination of education and experience #LI-AR1 Pay Range: $312,000 - $468,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group based in Boston's Seaport District. The Health Economics & Outcomes Research Associate Director will participate in the shaping and execution of HEOR strategies that optimize the value proposition for Vertex's Cystic Fibrosis and early pipeline assets through each stage of development, including launch and post-launch phases. This position reports to the Senior Director HEOR, CF and Early Pipeline. Key Duties and Responsibilities: * Leads execution of complex HEOR evidence generation studies, including: prospective and retrospective observational studies, systematic literature reviews, cost-effective analyses and budget impact models, Indirect Treatment Comparisons, COA strategy, PRO measure development and validation, as needed, to support the asset value * Effectively leads external research partners to ensure robust scientific methods are applied to study design and execution and in compliance with all local regulations; is accountable for study design, data analysis and the quality of the evidence produced. Excellent project management is a pre-requisite to ensure studies delivered on time and within budget. * Collaborates with the medical communications teams on publication strategy and ensure that dissemination of HEOR evidence is timely and has maximum impact * Partners and works closely with Global Pricing and Market Access to support development of product value proposition/value messaging and co-lead development of robust Global launch deliverables (e.g., global value dossier) Knowledge and Skills: * Strong track record of publication in peer-reviewed journals * Strong background in clinical outcome assessment (COA) measurement strategy; experience in PRO development/validation and qualitative research methodology * Technical expertise in HEOR; able to formulate and lead creative research projects and ensure conduct is technically and scientifically rigorous and reflects best HEOR practices * Strong verbal and written communications skills, including presentation skills to communicate difficult concepts and persuade others; comfortable communicating complex concepts and adapting presentation style to a variety of audiences * Ability to apply knowledge of US healthcare system, global health technology appraisal requirements, and clinical development, to identify evidence gaps and formulate evidence generation strategies * Understanding of the legal and regulatory environment of the pharmaceutical industry, with spotless history of compliance and ethical workplace conduct Education and Experience: * Advanced degree (PhD, MD, Master's degree, MPH, or PharmD) in a relevant discipline. * Typically requires 8 years of experience, with substantial background in HEOR, or the equivalent combination of education and experience Pay Range: $172,000 - $258,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you'll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We're passionate about innovation, inclusion, and supporting your growth-inside and outside the lab. Why Vertex? Real Projects: You'll work on assignments that make a real impact, not just busy work. Mentorship & Networking: Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career. Flexible & Supportive: We offer flexible work options with Flex @ Vertex and prioritize your wellbeing. Inclusive Culture: Collaboration and inclusion are embedded in everything we do. Career Launchpad: Build skills, explore career paths, and get guidance for your future career. Ready to apply? Submit your application and let's turn possibilities into reality! Your Impact The Vertex Single Cell Genomics Co-Op program is a 6-month experiential training program for students currently working towards an advanced degree in Systems Biology, Developmental Biology, Stem Cell Biology, Biochemistry, Biological Engineering, Chemical Engineering, or other related fields. If you are passionate, collaborative, and growth-minded, a co-op at Vertex will help you gain meaningful experience in our analytical sciences functional areas and serve as a launchpad for your career. Please note that Vertex reviews applications on a rolling basis and reserves the right to close this job posting prior to the listed deadline. Important Notice Regarding Internship and Co-op Inquiries At Vertex Pharmaceuticals, we are committed to providing a fair and structured recruitment process for all students interested in internship and co-op opportunities. To ensure consistency and equity, all student applications must go through our Early Talent Acquisition Team. Due to the high volume of interest, we are unable to respond to individual solicitation. Direct solicitation to Vertex employees- including senior leaders via email will result in removal from the recruiting process.' We appreciate your enthusiasm and interest in Vertex. To be considered for internship or co-op roles, please apply directly through our official application channels. (********************************************************************* Thank you for respecting our process and helping us maintain a fair experience for all candidates. What you will be doing: The co-op student's primary role is applying bioinformatics skills to interpretate bulk and single cell RNA sequencing data to deepen our understanding of the stem cell differentiation process, and monitor the differentiation progress. Specifically, they will use bioinformatics tools, such as Seurat or Scanpy, to map time course differentiation trajectory and identify potential correct and wrong trajectories of our process. Using the knowledge gained in this activity, the candidate will then nominate lists of genes to enable development of other RNA-based assays to closely monitor stem cell differentiation process. The co-op student will also assist in wet lab construction of single cell RNA sequencing libraries, and operation of Illumina sequencers. Key Deliverables at Project Completion: Daily mapping of our differentiation process using available single cell RNA sequencing data. A collection of wrong differentiation trajectories and a collection of potential failure modes identified by single cell RNA sequencing. Lists of RNA targets to monitor correct and wrong differentiation trajectories. Key Learnings Expected: Skills on single cell RNA sequencing library construction, data analysis and data visualization. Deeper understanding of developmental biology, stem cell biology, and stem cell engineering. Presentation of large and complex data. What you will need to succeed: Enrolled in a graduate program in Systems Biology, Computational Biology, Developmental Biology, Stem Cell Biology, Biochemistry, Biological Engineering, Chemical Engineering, or another related field Analysis, visualization, and interpretation of next-generation sequencing (NGS) data. Experience with Seurat, Scanpy, DESeq2 and other bioinformatics tools used for single cell RNA sequencing and bulk RNA sequencing data analysis is preferred. Proficiency with R, Python, Linux systems, high-performance computing systems Fundamental knowledge in developmental biology, stem cells and differentiation are preferred Fundamental knowledge in sequencing library preparation and sequencer operation are preferred A team-oriented growth mindset that welcomes feedback from others and supports other team members; strong collaboration skills to work across teams and functions A positive attitude that enthusiastically tackles and overcomes challenges Strong organizational and time-management skills to prioritize needs Excellent presentation and communication skills, including the ability to tailor scientific content to audiences with different backgrounds Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization. You must be enrolled in an advanced degree program if graduating before June 2026 You must be available to work full-time, 40 hours per week from January - June 2026 Program Details: Full-time, paid co-op $26.00 - 50.00 USD/hour Program Dates: January - June 2026 At Vertex, we believe that when you feel your best, you can perform at your best. That's why our US benefits and global well-being resources are designed to support you. • Free 24/7 onsite gym access and free access to group exercise classes • Subsidized commuter benefits- transit and parking • Provided meals-free breakfast daily! • Career development opportunities and events, including C Suite engagement • Social events-both intern-only and company-wide • Location-specific perks and extras! • Recognition of National Intern Day Our Ways of Working Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Equal Opportunities Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Vertex is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. Accessibility & Accommodations We're focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Vertex is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Export Control Notice This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant's ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role, Vertex is unable to sponsor non-U.S. persons to apply for an export control license. This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking a highly skilled technical leader to join our Process Development / Engineering team to lead and manage activities related to cell line development (CLD) for the production of monoclonal antibodies and other therapeutic biologics, with a strong focus on overseeing programs conducted at external CDMOs. This role is critical in advancing our pipeline of innovative biologics from early development through to commercial readiness. The Vertex Process Development team offers a dynamic, fast-paced, and highly collaborative environment with a tremendous impact on our programs and for our patients. Our team focuses on bringing together the best process design, scale-up and cutting-edge manufacturing technologies to enable the successful implementation of Biologics, Cell and Genetic therapeutics. The successful candidate will bring deep technical knowledge in cell line development and act as the technical lead for CLD work. This is a highly cross-functional role that will work closely with drug substance development, analytical development, external manufacturing and supply chain management in CMC teams to drive technical and strategic decision-making. Key Duties and Responsibilities: * Lead phase-appropriate strategies to develop, select, and characterize stable, high-producing cell lines for monoclonal antibodies, ADCs and other biologics modalities. * Evaluate, select and manage external capabilities for cell line development. * Oversee and review all aspects of the CLD process, including vector design, transfection, clone screening, characterization and cell line stability studies. * Ensure regulatory-compliant cell line development workflows, including clonality documentation and cell bank generation. * Develop and manage project timelines and budget for CLD activites. * Ensure project deliverables, quality standards, and timelines are met in alignment with internal program goals. * Collaborate with internal cross-functional teams including Process Development, Analytical Development, Quality Assurance, and Regulatory Affairs to ensure alignment and knowledge transfer. * Review and approve technical protocols, development reports, and data packages provided by CDMOs. * Provide scientific and strategic input into cell line platform development, technology evaluation, and implementation of innovation from external partners. * Support regulatory submissions (IND/IMPD/BLA) by contributing to or authoring relevant sections and responding to agency queries related to CLD. * Serve as a subject matter expert in regulatory agency interactions, audits, and inspections. * Expected travel: 10-20% (domestic and international) Required Education: * PhD in Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences or related discipline with commensurate years of education and experience. * Minimum of 8 years of experience in drug substance development and manufacturing. MS with 12+ years of relevant experience may be considered. Required Experience and Skills: * Demonstrated expertise in cell line development for therapeutic proteins including antibodies, ADCs, and fusion proteins. * Strong understanding of molecular biology techniques, vector construction, clone selection strategies, and cell line characterization methods. Familiarity with industry-leading expression platforms (e.g., GS, CHOZN, CHEF1, etc.) is strongly preferred. * Knowledge of upstream process development and analytical methods related to CLD. * Hands-on experience managing external CDMOs and navigating cross-functional and cross-organizational workflows. * Experience in authoring and reviewing relevant CMC sections of regulatory filings (IND, BLA, etc.). * Proven track record of delivering on complex biologics development programs. * Excellent interpersonal, communication, and organizational skills. * Ability to work independently, manage multiple projects simultaneously, and operate in a fast-paced environment. #LI-LE1 Pay Range: $166,800 - $250,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Director of Financial Planning and Analysis, Biopharmaceutical Sciences and Manufacturing Operations (BSMO) is a key member of Vertex's Financial Planning & Analysis team. This role will partner closely with Commercial Manufacturing and Tech Ops (CMTO), Commercial Finance and Disease Strategy Team (DST) Finance in support of our Cell and Gene Therapies portfolio, with a specific focus on CASGEVY, the first-ever approved CRISPR-based gene-editing therapy used to treat Sickle Cell Disease and Transfusion-Dependent Thalassemia. This role will have the opportunity to work across the organization by providing analysis and insights that will drive key decisions around manufacturing strategy and resource allocation in order to optimize the profitability of CASGEVY. In addition, this position will be an integral part of the BSMO Finance team and play a key role in support of P&L, Capital and Inventory budgeting, forecasting, long range planning, and month-end close processes. This position is based in our Boston, MA location (Seaport area) and requires a hybrid work schedule with 3 days in office /2 days remote on a weekly basis. Key Duties & Responsibilities: * Partners with the External Manufacturing, Supply Chain, and Commercial functions to influence CASGEVY business operations and optimize decisions as part of the Sales and Operations Planning (S&OP) process. * Identifies ROI/trade-off opportunities to drive profitability and support key decisions around CASGEVY manufacturing and supply chain strategy. * Oversees the monthly/quarterly accounting close for expenses and accruals related to CASGEVY Operating Expense and COGS, including flux analysis and compliance with SOX control requirements. * Supports analytics and transparent reporting to drive forecast accuracy and inform on key drivers of any variances to plan, with full transparency on any judgments about risks and opportunities for both operating expenses, capital expenses and COGS. * Supports the financial planning process (annual budget, forecasts, long range plan, etc.) by providing forward-looking observations and developing key scenarios. * Develops and coaches team members to encourage growth and new opportunities and contributes to an atmosphere of inclusivity across the team * Works closely with other members of the CFO organization including Commercial Finance, DST Finance, Strategic Sourcing and Accounting to maintain a continuous improvement mindset and promote strong communication, sharing of best practices and efficient processes. Basic Requirements * Bachelor's degree in Finance or Accounting required. MBA and/or other advanced degree preferred. * 10+ years of relevant experience in finance managerial role, demonstrating strong technical and analytical skills and a track record of success working in a team-based environment or the equivalent combination of education and experience. * Experience in business partnering with Manufacturing/Supply Chain executive teams * Proven ability to proactively manage efficient processes across Operating Expenses, Inventory and COGS, driving high-quality inputs from the business in support of creating and managing complex budgets, forecasts, and analyses in a dynamic, fast-paced environment. * Deep understanding of Biotech/Pharma manufacturing finance to address a broad range of challenges and business issues across all functions with the ability to make and facilitate quick decisions * Expert analytical and financial modeling skills to evaluate a broad range of financial questions. * Excellent communication and presentation skills, with a proven ability to present complex financial insights to senior stakeholders. Knowledge and Skills: * Strategic thinking and problem-solving. * Critically, this role requires an expert ability to influence without authority at the highest level and collaborate effectively in support of shared goals. * Strong business acumen and judgment, and knowledge of the company's markets/products and industry trends. * Expertise with Excel and PowerPoint; Working knowledge of Hyperion or similar enterprise planning tools. * Exceptional interpersonal, written, and verbal communication skills * Ability to lead and drive change in an evolving business environment, coordinating processes involving large numbers of people, complex systems, and tight deadlines to deliver innovative solutions. * Demonstrated ability to lead and collaborate cross-functionally, sharing insights and translating learnings into actionable business initiatives whilst partnering to ensure timely execution of project plans * Proactive, organized, and comfortable managing shifting priorities in a rapidly changing environment. * Leads with a continuous improvement mindset, with flexibility and ability to adapt to change. Pay Range: $182,400 - $273,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Through internal audits the Internal Audit Manager will identify risk areas, evaluate business process controls and complete test plans on operational audits. Additionally, this role will provide recommendations to improve the effectiveness and efficiency of operations and business systems. This role will also participate in ensuring that the yearly internal control review is brought to fruition by interacting with SOX testers, other stakeholders, and subject matter experts on special projects and the development and execution of departmental goals. Key Duties and Responsibilities: * Plans and performs financial, operational and, as applicable, IT audits; reviews related records for compliance with established and relevant reporting policies and procedures and is responsible for the end-to-end execution projects. * Applies financial and quantitative analyses and risk assessment procedures, documents findings/work papers in support of departmental goals and objectives * Maintains and applies an understanding of generally accepted accounting principles/standards and/or general IT frameworks * Identifies and effectively communicates (both verbally and/or in writing) audit results, control weaknesses, accounting/reporting/application deficiencies, process or company risk, business productivity and efficiency opportunities, departmental vision, and any other relevant matters to management or other applicable parties * Reviews, appraises and tests the internal controls surrounding business processes to assess compliance with the Sarbanes-Oxley Act * Collaborates constructively and respectfully with fellow audit team members and business stakeholders including with multicultural teams and in global locations * Maintains communication with the Engagement Director, responds to feedback and adjusts approach as the situation warrants * Contributes in management meetings, presents findings, conclusions and recommended actions to business management Knowledge and Skills: * Experience within Life Sciences or related sector * Excellent organizational and project management skills * Excellent written and verbal communication skills * Detail oriented, able to multitask and meet deadlines * Able to work under general supervision and work collaboratively with diverse teams * Expanded knowledge of audit methodology, risk assessment and internal control concepts * Ability to analyze process workflows and identify gaps and bottleneck * Ability to perform data analytics, SOC1 reviews and understand ITGCs * Obtain and provide training to the audit staff to support all aspects of Internal Audit activities to ensure that approved audit objectives are met * Ability to operate effectively independently and in a team-oriented, multiple location environment * CPA, CIA or CISA certifications or equivalent Education and Experience: * Bachelor's degree in accounting/finance/information systems or related field * Typically requires 5+ years of auditing experience (Big 4 strongly preferred) or the equivalent combination of education and experience. #LI-DB1 #HYBRID Pay Range: $111,700 - $167,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Associate Director, GMP Operational Quality is an advanced technical resource in the principles and application of quality assurance and compliance. This role is responsible for primary QA oversight of commercial drug substance manufacturing performed at Vertex's external vendors as well as secondary quality support of commercial drug product manufacturing vendors. This position ensures robust sterile manufacturing controls, commercial supply continuity, support for global jurisdictional expansion, and high‑level combination product quality alignment. The incumbent will mentor team members to provide individual development in addition to efficient and valuable service to project teams. Key Duties and Responsibilities: * Collaborate with internal and external business partners to resolve complex quality issues to ensure compliant solutions * Oversee CMO/Vendor performance, establishment of Quality Agreements and adherence of Quality Agreement terms * Enable team to achieve team goals/objectives and enable their individual career development * Develop and maintain compliant quality processes to support GMP activities * Oversee the QA support of Change Controls, GMP investigations and associated CAPAs. * Performs review and approval of master and executed batch records to support drug substance (DS), drug product (DP), device (Autoinjector) and finished goods (FG) disposition activities * Track performance metrics and report to Sr Management; develops tactics to improve performance outcomes * Participate in inspection readiness activities and lead Quality development discussions as necessary during regulatory site inspections. * Support review of regulatory submissions, as applicable * Lead continuous improvements of department processes, realizing efficiency gains, and ensuring team continues to meet expanding business needs with lean resources. * Lead and follow up on any QLT action items assigned. * Identify and communicate risks and assist with risk mitigation plans as necessary * Supports internal audit or external audit programs; assists in preparation of audit responses * Provide comprehensive knowledge support for partner and regulatory agency audits * Assist management team in budgeting and scheduling * Responsible for the following activities related to people management responsibilities: * Talent Acquisition/ Recruiting/Interviewing/ Selection/Onboarding * Accountable to provide oversight of day to day team operations Knowledge and Skills: * In-depth and specialized knowledge of both the conceptual and practical application of cGMPs in a pharmaceutical setting; in-depth knowledge of global GMP requirements and managing quality in support GMP manufacturing * Demonstrated success in building high-performing teams and skilled at managing team and individual development * Strong management skills with the ability to lead and motivate a team in a fast-paced environment while maintaining a high degree of quality, accuracy and timeliness * Substantial background in managing complex projects/teams within stated objectives and timelines and with a strong understanding of the underlying business drivers; skilled at applying project management processes / tools to lead meetings, assist with project planning, and facilitate attainment of project objectives * Ability to independently lead cross-functional teams and represent the interests, strategies and objectives of Quality unit * Strong skills in mentoring staff and transferring technical knowledge to enable their capabilities and development * Ability to communicate cross-functionally to a wide variety of audiences; exchanges complex concepts with the ability to influence leaders, customers, or vendors to adopt of a new point of view and/or to take action * Demonstrated ability to evaluate complex quality matters and make decisions utilizing risk-based approach; identifies and leverages the appropriate expertise to implement solutions * Substantial experience successfully leading event investigations, Root Cause Analysis (RCA), and CAPA * Extensive exposure with multiple regulatory agencies across applicable GxPs during inspections * Supstantial experience with electronic document management systems (e.g., Veeva) Education and Experience: * Bachelor's degree in a scientific or allied health field (or equivalent degree) * Typically requires 8+ years of work experience and 2 years of management experience, or the equivalent combination of education and experience #LI-hybrid Pay Range: $154,100 - $231,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Associate Director, Biostatistics will perform sophisticated scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with minimal guidance and mentoring on new and complex issues. The incumbent will completed work in a resourceful, self-sufficient manner and create alternative approaches to achieve desired results. The incumbent is capable of independent strategic and technical contributions. The incumbent should possess a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset. Key Duties and Responsibilities: * Conducts all scientific and operational statistical work for multiple clinical trials, observational studies, or real world data (RWD) investigations. * Leads biostatistics projects or major components of a project including work allocation and review. * May include presentation to the Peer Protocol Review Committee (PPRC) or other internal senior review boards. * Possesses an advanced and in-depth understanding of modern drug discovery and development processes. * Represents Biostatistics as a member of cross functional teams, providing input and specialized technical guidance to elicit meaningful and/or productive outcomes. * Authors study Statistical Analysis Plans (SAPs), including table, figure, and listing (TFL) shells. Develops Cross-functional Data Review (xFDR) plan, Key Reports Memo (KRM), and Data Dissemination Plan (DDP) in order to facilitate the review, summary, and dissemination of key study data/results. Knowledge and Skills: * In-depth competence with SAS and R statistical software * In-depth understanding of advanced statistical methods used in drug development * Ability to show critical thinking with logical problem-solving * Excellent written and verbal communication skills * Excels in a team environment * Collaborates well with non-statisticians * NDA/MAA experience and direct dealings with USA/European regulators Education and Experience: * Ph. D. or master's degree in Statistics or Biostatistics. * Typically requires 7 years of experience with a Ph.D. #LI-AR1 #LI-Hybrid Pay Range: $164,800 - $247,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Associate Director, Medical Writing Science manages the overall operations of a team or major project and implements this through effective leadership. This role provides guidance and leadership for document development for regulatory filings and coordinates the clinical sections of more complex regulatory submissions, including organization, content, and resource requirements. This role applies advanced technical expertise and develops solutions to complex problems, fosters interdisciplinary understanding, and integrates Medical Writing Science department activities with those of other departments. This is a hybrid role which allows for 2 days per week remote work and 3 days per week in the Boston Fan Pier office. We offer a full relocation package. Key Duties and Responsibilities: * Independently authors routine and complex clinical and regulatory documents * Provides strategic input into program-level plans * Deep insight into how different functions contribute to the successes of the team * Aligns, coordinates, and builds consistent information and messages across clinical program(s) * Provides leadership related to the activities of Medical Writing Science and manages a team * Participates in developing and implementing goals and initiatives for Medical Writing Science * Facilitates implementation of new technologies and initiatives related to the preparation of clinical documents * Proactively anticipates risks, solves complex problems, and seeks out and implements process improvements Knowledge and Skills: * Demonstrated aptitude for planning, managing, and optimizing department resources (e.g., staff, technology) to maximize and streamline the advancement of company goals and objectives * Record of leadership, independence, and ability to solve non-routine, complex problems involving a broad range of issues * Proven track record of anticipating potential problems and preparing contingency plans as needed * Understanding of scientific disciplines beyond own specialty area * Experience managing direct reports and guiding staff development * Experience with marketing authorization application regulatory submissions Education and Experience: * Bachelor's degree in relevant discipline * Ph.D. (or equivalent degree) * Typically requires 8 years of work experience and 2 years of supervisory/management experience, or the equivalent combination of education and experience #LI-AR1 #LI-Hybrid Pay Range: $157,600 - $236,400 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Remote-Eligible Flex Eligibility Status: In this Remote-Eligible role, you can choose to be designated as: 1. Remote: work remotely five days per week and come into the office on occasion - you're always welcome on-site; or select 2. Hybrid: work remotely up to two days per week; or select 3. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Remote Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex Pharmaceuticals has an exciting opportunity for a Research Scientist in the field of medicinal chemistry. Job responsibilities include the preparation of both single and focused sets of small organic molecules, developing and optimizing synthetic methods, creating and interpreting project-relevant Structure-Activity Relationship (SAR) and problem solving. Candidates must demonstrate an expert understanding of organic reaction mechanisms, formulation of executable synthetic routes, up to date understanding of contemporary synthetic methods as well as an ability to balance rational concepts with creativity which includes the development of new synthetic methodology as needed. The successful candidate will have the ability to work independently and be able to multi-task collaboratively in teams while adapting to rapidly changing needs. A strong desire to grow as a medicinal chemist while maintaining a passion for organic chemistry and the courage to challenge conventional wisdom are essential in this role. Key Responsibilities * Maintain a high level of productivity in the laboratory setting * Develops and executes clear synthetic routes using state-of-the-art synthetic methodologies * Primarily responsible for executing organic syntheses in a timely, efficient, and independent manner * Create and interpret SAR with a clear understanding of the biological data * Organize and triage efforts to stay consistent with project priorities * Clearly and effectively communicate ideas and results (both verbally and in writing) to a broad range of audiences Knowledge And Skills * Designs and executes complex, challenging chemistry experiments * Demonstrates astute understanding of his/her own discipline and the relevant literature * Maintains a high level of knowledge related to current developments in the scientific project field * Displays proven productivity and experimental creativity, and effective dissemination of ideas * Demonstrates effective, self-sufficient communication skills, especially in peer-directed presentations * Demonstrates awareness of other project-related disciplines and an understanding of general concepts and some experimental detail within those areas Education And Experience * Ph.D. (or equivalent degree) in chemistry or related science 0-3 years of relevant post-doctoral employment experience, or * Master's degree (or equivalent degree) in chemistry or related science and 3+ years of relevant employment experience, or * Bachelor's degree (or equivalent degree) in chemistry or related science and 6+ years of relevant employment experience * Demonstrated effective communication skills, both verbal and written * Ability to navigate and be successful in a fast-paced, highly matrixed work environment * A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society Pay Range: $100,000 - $150,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

As a key Team Manager and leader in the Strategic Sourcing function, the Director, Strategic Sourcing Enterprise Third-party Risk Process & Governance leader is responsible for leading the operational execution of the end-to-end third party risk process as a key member of the Central Risk Management team. This role is responsible for shaping, driving and managing central third-party risk management processes, supporting cross-functional teams, and ensuring consistent application of risk policies and procedures across the third-party/supplier life cycle. The Director will collaborate closely with business owners, risk SMEs, sourcing teams and the rest of the Central Risk Management team to assess, monitor, and mitigate third-party risks, while driving process efficiency and compliance. The leader will play a key role in expanding the current risk processes and implementing the new processes, including driving change management, for more holistic third-party risk management practices across the company. The leader will work collaboratively with internal Stakeholders, develop sound third party risk approaches, utilize knowledge and expertise of processes, leverage best practices and drive risk visibility and ultimately risk management actions and a transparent enterprise governance process for managing and underwriting risks. The ideal candidate is a forward-thinking leader with a deep understanding of pragmatic third party risk processes, tools and technology, change management, and user-centric design principles. This role reports to the Senior Director of Strategic Sourcing Enterprise Third-Party Risk Management and will serve as a key contributor to the enterprise third-party risk management strategy, with a focus on execution, governance and reporting, and continuous improvement. Duties & Responsibilities: Operational Leadership * Lead initiatives to implement the expanded third-party risk management processes, including change management * Manage day-to-day operations of the holistic centralized third-party risk management process. * Oversee supplier criticality assessments and ensure consistent application of risk evaluation tools. * Maintain and update the supplier risk repository, including tracking mitigation actions and ownership. * Support and coordinate risk assessments for critical suppliers in partnership with business leads and risk SMEs. * Support the development and automation of risk metrics and dashboards for visibility and reporting. * Assist in maintaining enterprise third-party risk management tools such as the risk appetite matrix and risk mitigation playbooks and ensure alignment with business inputs. Governance & Compliance * Support governance forums and escalation processes for individual third-party risks as well as risk themes by coordinating inputs and developing fit for purpose material including reporting, key metrics, and executive summaries * Ensure compliance with and continue to evolve internal processes, policies, and understanding of regulatory requirements, and industry standards. * Pro-actively engage risk SMEs and external risk and industry forums and sources to understand potential changes in regulations and laws that could implicate our third-party/supply base and/or risk processes. * Partner with internal audit, compliance, legal teams and other risk owners across the company to align and continue to evolve risk practices. Cross-Functional Collaboration & Continuous Improvement * Work with strategic sourcing and business owners to integrate third-party/supplier landscape insights into risk strategy. * Collaborate with HR, Communications and business teams to support training and awareness initiatives. * Serve as a liaison between risk SMEs and business units to ensure effective execution of risk practices. * Identify opportunities for process optimization and automation. * Benchmark practices against industry standards and contribute to ongoing enhancements of the TPRM framework. Leadership & Change Management * Partner with senior executives, business leaders, DTE, and suppliers to realize the tools and technology evolution to effectively expand and support risk processes * Align risk processes with overall business objectives and collaborate with key stakeholders to understand evolving risks; own, develop and embed tools and processes to enable consistency, simplification, and sustainability of pragmatic third-party risk management across the business. * Foster strong partnerships and a culture of continuous and balanced third-party risk mindset and decision-making across the company. Success Measures * Increased adoption and satisfaction with third-party risk programs * Demonstrated value of enhanced third-party risk management practices * Reduction of process cycle times, and elevated focus on critical third-parties and risks * High stakeholder engagement and positive business feedback on value and effectiveness of third-party risk programs. Required Qualifications: * Bachelor's degree in Business, Finance, Risk Management, or related field. * Professional certifications (e.g., CRMA, CTPRP, CISM) preferred. * 8-12 years of experience in risk management, sourcing, or compliance, preferably in a biopharma or regulated industry. * Experience managing third-party risk programs or supplier risk assessments Pay Range: $174,400 - $261,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex Pharmaceuticals is looking for a Senior Accountant I to join its team and support the accounting operations within its Global Accounting Function based in Boston, United States. As a key member of the end-to-end Record-To-Report ("RTR") function for 20+ countries, the successful candidate will play a vital role in maintaining accurate financial records, ensuring compliance with the company's accounting policies, and supporting Vertex's financial objectives. Your expertise will contribute to the efficiency and effectiveness of Vertex's financial operations on a global scale. The position will partner with other members of the accounting team and provide exposure to teams across other departments, including Treasury, Accounts Payables, Revenue, Finance and offers development opportunities that can lead to advanced roles within Vertex. Leveraging analytical skills and accounting expertise the successful candidate will have the opportunity to make suggestions and implement improvements to ensure continuous enhancement of the international organisation. Key Duties and Responsibilities: MONTHLY RESPONSIBILITIES: * Independent preparation and/or review of monthly and quarterly journal entries and account analyses and reconciliations for a number of general ledger accounts across Vertex's various entities. * Provide support to treasury accounting and accounts payable function by resolving discrepancies to provide a clear and accurate financial picture. * Provide support to the general ledger function by business partnering with the Accounts Payable function to maintain and reconcile Accounts Payable Clearing and Concur Clearing accounts. * Support with new and on-going accounting projects. Proactively provides observations/recommendations to all levels of management on gaining efficiencies in the monthly GL Close process. Experience with robotics and project management tools a plus. * Coordinate SOX documentation and testing with the internal and external auditors and ensure internal policies and SOX procedures and controls are adhered to. OTHER RESPONSIBILITIES: * Identify opportunities for process optimisation and automation to enhance efficiency, accuracy, and scalability within the IFSSC. * Assist the team handling of any non-routine reporting transactions and ad-hoc accounting projects as required. * Build a partnership of trust and open communication with Vertex's other accounting and finance functions and key stakeholders. * Assist with internal audit and SOX queries, including any audit questions as required. Knowledge and Skills: * Previous experience in a similar accounting role. * Strong understanding of international accounting standards (e.g., IFRS, U.S. GAAP) and regulatory requirements. * Excellent communication and interpersonal skills to collaborate across all levels of the business. * Proven communication, negotiation and influencing skills in working with multiple stakeholders across multiple departments. * Excellent Microsoft Office skills including advanced Excel expertise able of manipulating large data sets and modelling skills. * Oracle R12, OBIEE, HFM / SMART View (Essbase data sources) and / or Blackline experience is an advantage. * Experience working in a Global Accounting Functions and within a SOX compliant environment would be an advantage. * Knowledge / experience working in a corporate accounting environment, preferably at a Financial Shared Service Centre. * Biotechnology or pharmaceutical industry experience is an advantage. Education and Experience: * Typically requires Bachelor's degree or equivalent in accounting, finance or related field * Typically requires 3 years experience or the equivalent combination of education and experience * Experience in a corporate accounting environment Pay Range: $84,000 - $126,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

As the Senior Manager of Sales Planning and Incentive Compensation you will be supporting the administration, execution, and delivery of our Sales Planning & Incentive Compensation (IC) services for the Pain BU. This includes the sales team alignments, targeting, and incentive compensation deliverables. You will be a strong collaborator with the Associate Director of Sales Planning & IC and Pain business unit team to proactively recommend sales planning and IC strategy to ensure alignment with brand objectives, as well work with internal team members, vendors, and provide individual work contribution in the delivery of these services to meet business expectations and on-time, quality deliverables. In addition, you will be responsible for Veeva Align maintenance. This includes managing & maintaining sales roster, alignments, business rule creation & enhancements, territory design and ZTT changes. This is a hands-on role and will require both tactical experience and expertise in pharmaceutical sales planning, IC, and data management to ensure the "end-to-end" planning and delivery of all sales planning and IC services. Key Duties and Responsibilities: Sales Planning: * Support field alignment projects and territory mapping as needed for the BU and data source optimization. * Align on Targeting and Call Planning structure for field force prioritization based on business unit strategy, data insights/modeling, sales leadership reviews, and ongoing refinements based on field or brand insights, strategic objectives, and field size and role evolution. * Work with Data Management, IT, and other internal stakeholder to ensure proper loading of customer data, targeting refreshes, alignment management, and supplier data delivery receipt. * Optimize and recommend data sources to be used in Sales Planning activities across all field role types including IDN, Institution, and HCP field teams, leveraging data sources such as Retail, Institution, Specialty Pharmacy, and other available data tools and suppliers. * Veeva Align responsibilities which include managing & maintaining sales roster, alignments, business rule creation & enhancements, territory design and ZTT changes Incentive Compensation: * Assist in developing IC Design for business unit based on brand and field leadership business objectives for annual IC Plans, as well as opportunities for Contests & Awards to ensure all incentive plans are motivational, compliant, and equitable. * Plan and deliver IC Calendar to ensure all stakeholders are aligned and accountable in the quarterly processes in delivery of IC Goals, Data Delivery/Processing, Scorecards, Field leadership reviews, and Payout file deliverables. * Development of IC SOPs and KPIs to ensure accuracy, on-time delivery, and compliance adherence to all IC components. * Answer questions for Business Unit and field education of IC Plans, data sources and business rules, and scorecards/payout delivery, to ensure high understanding of the IC plans/contests/awards, minimal discrepancies and inquiries, and optimal accuracy. * Previous experience with retail data a plus Knowledge and Skills: * Proficient in pharmaceutical sales planning and incentive compensation design and delivery * High expertise in pharmaceutical sales data sources and data suppliers across retail, institution, and specialty pharmacy prescription and customer data sets * Expertise in brand/sales leadership collaboration and consultation for plan design and engagement, field communications and support, and operational delivery of sales planning and incentive compensation components * Familiar with Sales Planning and Incentive Compensation tools and vendors to optimize delivery accuracy and efficiency. * Ability to lead and partner well with internal operational delivery stakeholders including IT, Data Management, Data Suppliers, Compliance, Legal, and Vendor support companies to align and agree to deliverables, quality levels, and ongoing inquiry/operational support service levels * Excellent communication, presentation, and external stakeholder engagement abilities Education and Experience: * Bachelor's degree and 5-7 years of experience in pharmaceutical data/sales operations; including roles such as data management, sales operations, analytics, incentive compensation or sales planning roles. * Strong understanding of the life sciences industry * Proven leadership skills, strong communication and vendor management Pay Range: $126,000 - $188,900 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Director, Global Process Excellence, Finance Systems and Reporting is a key member of the Vertex Global Finance organization and will be leading continuous improvement workstreams including projects aimed at improvement of Global Finance processes, implementation and enhancement of finance systems and support of enterprise reporting capabilities. Reporting to the VP, Global Process Excellence, Finance Systems and Reporting, this role is a key leader in ensuring that Vertex's global R&D/BSMO finance teams can scale efficiently to meet the needs of an increasingly large and complex pipeline by optimizing global processes, implementing and enhancing finance systems and building new scalable global capabilities to enable efficient and effective enterprise planning and reporting. An important aspect of this role is the ability to have influence without authority, and to be able to maintain an enterprise-wide view where global processes and solutions are most effective and efficient for Vertex. Success in this role requires a deep understanding of Vertex's business and strategy including a strong understanding of R&D, BSMO and PPM processes, experience in designing and implementing global processes and finance systems, an ability to lead and manage change and to collaborate effectively within Finance and with other key stakeholders (Accounting, Internal Audit, DTE, PPM, HR etc.) to ensure strategic and operational alignment. Collaboration and strong partnership with R&D Finance, BSMO Finance (including cost accounting) and the PPM organization is paramount to success in this role. In addition, success will include an ability to lead and support process improvement projects. This includes partnering with project owners to plan and execute workshops, as well as help to create documentation where needed, and project manage follow ups and implementation when needed. Finally, this role will help develop continuous improvement skills within our global finance team, providing coaching, sharing tools and promulgating best practices. Key Duties & Responsibilities * Strategizes with finance and business leaders to identify and prioritize global R&D Finance process optimization opportunities to enable Vertex's efficient growth through industry-leading cross-functional innovation and business partnering. * Partners with Finance leadership to develop a strategy for that organization's efficient scaling on short term processes as well as the LRP. * Leads process and systems enhancement workstreams to help optimize the use of data driven insights to drive integrated enterprise decision making. * Enables VRTX growth by using data and technology platforms to enable operating efficiencies, growth and ability to scale with sustainable, compliant and risk balanced processes. * Drives implementation of VRTX global financial data structures to ensure that we are organizing and governing data to enable effective performance management and decision support as Vertex grows in scale and complexity. * Partners closely with Finance, PPM, HR, Accounting and DTE to ensure that Vertex is building integrated enterprise planning capabilities to enable short- and long-term decision making and resource allocation. * Collaborates and communicates effectively with others, identifies opportunities where change management is needed and helps to develop plans of action to address the gaps. * Helps to develop and coach more junior team members to encourage growth and new opportunities and maintaining an atmosphere of inclusivity across the team. * Utilizes data analytics and metrics to identify trends, make recommendations and mitigate resourcing and financial risks. Basic Requirements: * Bachelor's degree in business, Finance or Accounting. * MBA and CPA a plus. * Typically requires 12+ years of relevant experience in a finance managerial role demonstrating strong technical and analytical skills, and a track record of success working in a team-based environment or the equivalent combination of education and experience. Preferred Knowledge/Skills: * Possesses a continuous improvement mindset, constantly interrogating the way we operate with flexibility and ability to drive change. * Significant experience leveraging Lean and Six Sigma concepts to identify opportunities for improvement and to develop and implement action plans. * Experience partnering with cross-functional teams and processes; able to manage through ambiguity and influence with and without authority. * Must have vision for the future, an ability to think strategically on getting alignment across various groups, and an ability to partner effectively with R&D and BSMO Finance leadership. * Ability to find innovative solutions to complex problems, leveraging industry best practices and finding solutions that are fit-for-purpose for Vertex but also contemplate future business needs. * Ability to effectively work with and influence senior leaders including the DTE LT, FLT, HR LT and PPM LT individually and in gaining alignment amongst these groups when needed. * Strong interpersonal, written, and verbal communication skills. * Significant knowledge of drug development process with strong business acumen and judgment; knowledge of the company's markets/products a plus. * Strong project management ability and ability to manage multiple projects and areas of ownership. * Proactive, organized, and comfortable managing shifting priorities in a rapidly changing environment. #LI-DB1 #HYBRID Pay Range: $180,800 - $271,100 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Employer: Vertex Pharmaceuticals Incorporated JOB TITLE: Analytical Development Principal Research Associate OPENINGS: 1 * Design, develop, execute and analyze characterization and release assays for identity, purity, strength and potency of cell- based products. Multiple analytical platforms will be employed including RT-qPCR, SDS-PAGE, ELISA, Western blots, Flow cytometry, Flow-cam, dd PCR, Alphalisa and cell- based functional/ potency assays. * Execute test methods in support of pluripotent stem cell Process Development activities. * Troubleshoot, optimize, and trend assay performance. * Report on project progress, write analytical development protocols and reports, provide recommendations to management. * Identify, qualify, and manage analytical reagents as per regulatory standards. * Establish assay design criteria using Design of Experiments (DOE) and other contemporary development tools. * Perform statistical analysis to establish specificity, sensitivity, linear range, precision, and accuracy of test methods. * Establish reference standard materials as required to support assay validation. * Transfer assays to QC and provide SME support for assay qualification, author transfer/qualification protocols and reports. * Maintain excellent written documentation (e.g. lab notebook and test forms). REQUIREMENTS: Employer will accept a Master's degree in Biochemistry, Cell & Molecular Biology, Pharmacology and Toxicology or a related field and 2 years of experience in the job offered or in an Analytical Development Principal Research Associate-related occupation. Alternatively, employer will accept a Bachelor's degree in Biochemistry, Cell & Molecular Biology, Pharmacology and Toxicology or a related field and 6 years of experience in the job offered or in an Analytical Development Principal Research Associate-related occupation. Position requires demonstrable experience in the following: Developing analytical methods in compliance with ICH guidelines. Assisting with the following assay platforms: RT-qPCR, ELISA, Western blots, Flow cytometry or cell- based functional/ potency assays. Assisting with the culture of multiple mammalian cell types and combination drug product (Cells + device) Using literature to design proof of concept studies. Writing technical documents including development reports, qualification protocols and qualification reports. Rate of Pay: $88300.00 - $132400.00 CONTACT: Send Resume to *********************. Reference 12140.579. EOE. #LI-DNI Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

At Editas Medicine, we are pioneering the possible. Our mission is to translate the power and potential of CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. Why Choose Editas? At Editas Medicine, we're a team of passionate problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected and where you can operate at the forefront of gene editing, become an Editor! This role is to help advance our lead in vivo development candidate, EDIT-401, a potential best-in-class, one-time therapy designed to significantly reduce LDL cholesterol levels. The company is very excited by the potential of this experimental treatment which has demonstrated the ability to reduce mean LDL cholesterol levels by over 90 percent in non-human primates. If you are a candidate excited to help push the boundaries of what's possible in medicine, apply now. Decoding The Role: The Director, Project Management will lead the planning and execution of the cross-functional workstreams from pre-IND through to commercial launch. This role is responsible for leading cross functional partners in the development of a detailed program timeline in Smartsheet, clear functional budgets, and an aligned view of the program critical path. The Director, PM role will manage the weekly Program team meeting to ensure seamless cross-functional coordination of workstreams, to identify and mitigate program risks, and to successfully deliver to key program milestones (Pre-IND, IND, Phase I, II, and transition to registrational study). The ideal candidate will bring deep experience in clinical trial operations and project management within biotech or pharmaceutical settings, particularly in gene therapy programs. This position will operate in a highly matrixed, fast-paced biotech environment from Editas's Cambridge, MA headquarters. An ideal candidate demonstrates: Strong communication skills: this candidate is able to effectively partner with internal and external stakeholders across the team. This candidate balances inquiry with advocacy when engaging with teammates to ensure he/she fully understands a situation before engaging in problem solving. Organizational skills: this candidate is a detailed oriented planner, diligently confirming and aligning the functional plans of her / his peers. This candidate has a track record of establishing program structure; he / she enables a logical, process-driven approach to enhance collaboration across teams. Teamwork and leadership: This candidate possesses a highly collaborative mindset and is skilled at productive debate that builds team commitment to a recommended path forward. This candidate tests functional thinking and respectfully challenges his/her teammates to get to reasonable program assumptions. Adaptability: This candidate has demonstrated the ability to balance multiple priorities and adapt their approach to be successful in a fast paced, dynamic biotech environment. Characterizing Your Impact: As the Director, Program Management , you will: Lead the operational planning and execution of the cross-functional program plan; establish and reinforce a Program structure that enables cross-functional collaboration Develop detailed project plans including timelines, milestones, interdependencies, budgets, and the Program Team critical path Coordinate activities and deliverables across functional teams including Clinical, Non-clinical, Regulatory, CMC, and Data Management. Track progress against plans, identify risks, and implement mitigation strategies. Provide regular updates to leadership and governance committees. Requirements The Ideal Transcript: To thrive in this role, you'll need: A minimum of a bachelor's degree in life sciences or related subjects; advanced degrees (MBA) are desirable. 8-10 years of experience in biotech/pharma, with 3-5 years in program management supporting early-stage clinical development. Experience managing multiple programs at the same time is desirable. Proven track record of leading cross-functional teams in a matrixed environment. Strong understanding of preclinical development, IND-enabling studies, and early clinical trial operations. Experience across functional roles is desirable. Experience with gene therapy or gene therapy programs is highly desirable. Mastery of project management tools and methodologies, including Smartsheet, Microsoft Project, and OnePager Benefits Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy. Salary Range: $210,000 - $230,000 Pay Transparency Editas Medicine is committed to transparency and accuracy in our hiring practices. The anticipated salary range for each position is posted within the role. The final salary offer will be determined based on a comprehensive assessment of the candidate's qualifications, including education, training, and relevant experience. Additional factors such as external market conditions, the role's criticality, and internal equity will also be considered. Editas Medicine's compensation philosophy ensures fair and equitable pay practices. Aspire to be an Editor? We invite you to apply and join us at the forefront of innovation and be a key contributor to realizing Editas Medicine's mission of developing transformative medicines for people living with serious diseases.