Flagship Pioneering jobs - 83 jobs

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. Position Summary: Flagship Pioneering is growing our Capital Solutions and Value Realizations team and we are looking for an exceptional Associate to join us in building, shaping and crystallizing value across our ecosystem of breakthrough, first in category platform companies designed to transform human health, sustainability and beyond. This role is ideal for someone who thrives at the intersection of science, finance, strategy, and M&A and who is energized by working inside one of the most innovative environments in life sciences. Key Responsibilities Modelling, valuation and related analyses, and strategic assessments across the Flagship portfolio Scientific, clinical, market, and competitive landscape diligence Develop high-quality presentation materials and strategic communications Supporting initiatives across transaction execution, value realization, and direct private capital financing Partnering closely with senior leaders, company executives, and other teams across the Flagship ecosystem Qualifications Undergraduate degree in natural sciences and/or business Min 3 years of experience as an analyst and/or associate in healthcare investment banking Strong exposure to biotech equities and M&A products Advanced financial modelling and valuation capabilities Ability to distill complex scientific, clinical and market information into clear insights Strong verbal and written communication skills We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-NM1 The salary range for this role is $128,000 - $176,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

ProFound Therapeutics: Senior Director, IP Counsel Boston, MA USA ProFound Therapeutics is discovering proteins hidden within the expanded human proteome to uncover novel drugs and drug targets, producing first‑in‑class medicines for a multitude of diseases. The company's ProFoundry™ Platform uses state‑of‑the‑art protein detection technologies to systematically identify and validate proteins and dissect their therapeutic potential. The result is an ever‑expanding database of tens of thousands of novel proteins, including their connectivity, functionality, and roles in health and disease. ProFound Therapeutics was founded in 2020 by Flagship Pioneering. For more information, please visit ******************* Position Summary: ProFound Therapeutics is seeking a Head of Immunology to oversee and manage all work aimed at creating a pipeline of innovative assets based on proteins or peptides originating from the dark proteome. The head of Immunology will report to the Chief Scientific Officer. The ideal candidate will thrive in a collaborative fast‑paced environment and will provide the hands‑on work necessary to design and create our innovative pipeline of clinical assets. Key Responsibilities: Lead and oversee ProFound's immunology research and early development project portfolio. Develop, implement and apply innovative immunological assays and techniques. Design screening and assay strategies to characterize novel proteins and peptides in the immunology space. Collaborate with cross‑functional teams including biologists, protein engineers, and clinicians, including CROs. Create and present research strategies and portfolio developments to internal and external stakeholders. Stay updated with the latest clinical and pre‑clinical advancements in immunology and related fields. Qualifications: Ph.D. in Immunology/biology or a related field. Minimum of 8‑10 years of experience in immunology research. Ability to work collaboratively in a multidisciplinary environment. Strong statistical analysis and bioinformatics/genetics skills. Strong analytical and problem‑solving skills. Excellent project management and organizational skills. Excellent communication and leadership abilities. Values and Behaviors We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort working in and contributing to a dynamic and cross‑functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidate. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. About Flagship Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Learn more about Flagship at *************************** Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. The salary range for this role is $275,000 - $350,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. ProFound Therapeutics, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on ProFound Therapeutics, Inc.'s good faith estimate as of the date of publication and may be modified in the future. #J-18808-Ljbffr

ABOUT PIONEERING MEDICINES Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. Position Summary: We are seeking a Principal Scientist / Associate Director to serve as the nonclinical pharmacology lead across programs in inflammation, autoimmunity, and immuno-oncology. Reporting to the Head of Pharmacology, you will own the in vivo strategy from H2L through IND and partner seamlessly with Cell Biology, Translational Medicine, DMPK/QSP, Tox, and TechOps to generate robust, decision-quality data. You will work in a matrix environment guiding an internal in vivo team and managing an external network of CROs/consultants to design, execute, and interpret studies that define mechanism, dose/route/schedule, biomarkers, and combinations for Pioneering Medicines programs. Responsibilities: Serve as Pharmacology Lead on cross-functional program teams; define the in vivo plan, milestones, budgets, and success criteria from target validation to IND. Design and execute disease & target-relevant efficacy models and PD/biomarker readouts across inflammation, autoimmunity, and IO (contributing hands on when necessary). Partner with DMPK/QSP to translate exposure-response into dose, route, schedule, and combination recommendations. Introduce and build new models/technologies as fit-for-purpose. Work closely with other FSP companies to develop research strategies and evaluate new programs. Basic Qualifications: PhD, DVM, MS or equivalent in in vivo pharmacology or related discipline with a minimum of 5 years of experience within the Pharmaceutical/Biotechnology sector required. Extensive understanding of PK/PD assessments in models of disease and experience in designing ex vivo studies to assess PD and target engagement endpoints, is a must-have. Hands on experience with in vivo models of inflammation, autoimmunity and/or immunooncology preferred with PD endpoints including flow/IHC/cytokine assessments. Experience managing in vivo personnel and external CRO partners in a dynamic and fast-paced research environment. Additional Qualifications and Skills: Experience working with standard modalities, such as small molecules, antibodies and peptides desired. Experience working in program teams in a matrix environment. Working knowledge of gene-based therapy approaches (gene regulation, RNA medicine, gene therapy, gene editing, and/or gene silencing) desirable but not required. Collaborative mindset and a willingness to work with different teams. Experience with Animal Care and Use protocol writing Excellent communication and writing skills. LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $148,000 - $203,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

About the Role At Apriori Bio, we have built our unique technology platform Octavia™ to help survey viral landscapes and improve vaccine design towards increased efficacy and breadth. This role will serve as a critical part of this effort, sitting on the Platform team that develops and builds the key capabilities supporting Octavia. You will partner with our wet-lab scientists as well as our broader computational team to turn our high-throughput immune landscaping data into actionable insights and features for the design of better vaccine candidates. Additionally, you will develop innovative approaches predicting the ability of antigens to evade existing immunity, thus enabling the design of the next generation of variant-resilient vaccines. In this cross-functional role, you will have the opportunity to utilize our in-house and external databases, generate data-driven insights, and contribute to the expansion and refinement of Octavia™. Position Summary Apriori Bio is seeking a Data Scientist with a track record of developing and successfully applying analytical tools to high-throughput sequencing assays. This role is positioned at the interface between the high-throughput biological readouts that power Octavia and the expanding set of platform capabilities enabling the design of better vaccine candidates against infectious disease. Experience in the analysis and interpretation of high-throughput functional and/or genomic assays (e.g. deep mutational scanning, barcode-based NGS assays, and other library based phenotypic assays) is desired. The role requires strong data visualization and communication skills, as well as a proficency in bioinformatics. Technical expertise in protein engineering or structure, virology, vaccinology, viral phylogenetics and/or viral phylodynamics is preferable. This individual will join a dynamic, rapidly growing and collaborative team, and should also be comfortable in a fast-paced start-up environment. Core Responsibilities: Execute and manage high-throughput sequencing analysis pipelines Analyze and interpret results of high-throughput experiments, assessing relevance for associated programs and communicating evaluated results to program teams. Collaborate with wet-lab scientists to design experiments for assay development, program advancement, & expansion of the Octavia platform. Collaborate with broader Apriori team to develop and optimize new high-throughput assays to expand the capabilities & impact of Octavia Perform longitudinal data analyses to support experimental decision-making & platform development. Integrate various data sources to engineer useful features for predictive modeling & antigen design. Assist with organizing, extracting, and uploading proprietary experimental information programmatically with Benchling ELN's SDK. Create clear, user-friendly visualizations to be developed into dashboards and automated workflows. Regularly present platform progress in research and executive team meetings, creating comprehensive reports and slides for widespread communication. Uphold data management integrity and reproducibility through established software engineering best practices. Monitor cutting-edge technologies and models and identify potential collaboration opportunities across the Flagship Ecosystem. Qualifications and Skills: Ph.D. in life sciences or a quantitative field. Proficiency in writing production-standard Python code, especially with packages in the scientific computing ecosystem (NumPy, SciPy, Matplotlib, pandas, etc.). Experience with analyzing and interpreting high-throughput experimental data Solid bioinformatics background with proficiency handling and analyzing sequence data Strong scientific and quantitative acumen, with a demonstrated ability to integrate this acumen into platform & model building Familiarity with collaborative coding using GitLab best practices and commands. General proficiency with cloud platforms, specifically AWS. Demonstrable extensive experience or study in statistical/quantitative modeling & machine learning. Working knowledge of quantitative data pipelines, including workflow orchestration, ETL processes, quality control management, and reporting. Knowledge in at least one ML framework (PyTorch/TensorFlow/Jax). Effective working in fast-paced, highly collaborative, and matrixed teams. Exceptional communication skills, especially with requirements gathering and data presentation. Preferred Additional Skills: Familiarity with immunology, vaccinology, or infectious disease concepts. Previous experience in a biotech startup. Experience building technology to process high-throughput sequencing (HTS) assays, preferably display-based HTS systems like phage, yeast, and/or mammalian cell surface display. Hands-on experience with Databricks, including cluster management, Unity Catalog-based data workflows, Spark/PySpark, and developing SQL queries/dashboards. Knowledge of anomaly detection methods, structural biology visualizations, and data modeling. Familiarity with cloud native tools such as AWS s3 and ec2. Understanding of DevOps, change management, and technical documentation concepts. Ability to communicate effectively across various platforms, such as Jupyter notebooks, PowerPoint, Teams, and verbal discussions. About Flagship Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $115,000 - $165,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Apriori Bio, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Apriori Bio, Inc.'s good faith estimate as of the date of publication and may be modified in the future.

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Role Summary: The Project Coordinator plays a critical enabling role within BioMedicines, supporting Flagship-style operations that emphasize speed, clarity, and disciplined execution. This role helps keep teams aligned across a highly matrixed, global organization by coordinating projects, meetings, and shared information. The Project Coordinator acts as an operational connective tissue-reducing friction, increasing transparency, and enabling leaders and teams to focus on value creation. This individual needs to take the initiative to drive issues and actions forwardindependently to enable results. Key Responsibilities Program & Portfolio Enablement * Support cross-functional programs by tracking action items, milestones, and key decisions in a lightweight, execution-focused manner. * Ensure clear follow-up and accountability coming out of leadership, program, and governance meetings. * Help maintain rhythm across core operating forums (program reviews, leadership meetings, Flagship touchpoints). Meeting Coordination & Operating Cadence * Schedule and coordinate meetings to support the team being cognizant of global time zones, balancing speed with respect for team capacity. * Manage recurring operating and governance meetings, including agenda preparation, material readiness, and post-meeting action tracking. * Partner with meeting owners to ensure meetings are purposeful, decision-oriented, and well-documented. SharePoint & Knowledge Management * Maintain BioMedicines SharePoint as a single source of truth aligned with Flagship operating norms. * Ensure materials are current, clearly structured, and easy to navigate (programs, governance, decision logs, reference materials). * Support disciplined document hygiene, version control, and archiving. Cross-Functional & Global Team Support * Serve as a trusted operational partner to program teams, functional leaders, and Flagship stakeholders. * Support onboarding by enabling fast access to systems, documents, and ways of working. * Facilitate coordination across R&D, operations, corporate functions, and external partners. Continuous Improvement * Identify opportunities to simplify processes, reduce overhead, and improve information flow. * Help implement practical tools, templates, and working norms consistent with Flagship's lean operating model. Qualifications & Experience * 3-5 years of experience in project coordination, operations, or program support within biotech, life sciences, or similarly fast-moving environments. * Experience supporting highly matrixed teams and senior leaders. * Strong proficiency with SharePoint and Microsoft 365 (Outlook, Teams, PowerPoint, Excel). * Comfort working with ambiguity and evolving priorities. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-NM1 The salary range for this role is $88,000 - $121,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner? ABOUT PIONEERING MEDICINES Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. THE ROLE We are seeking a highly motivated and experienced Senior Director of Program Management to join our team. You will be responsible for developing and managing strategically important partnerships with pharmaceutical companies and with other Flagship companies. You will help establish best practices for Pioneering Medicines' existing and future programs. Since we are an entrepreneurial, high growth unit of Flagship, you will work as the Program Manager for at least one program at any given time. This is a high-profile role in our organization and an opportunity to work side by side with our leadership team. KEY RESPONSIBILITIES Program Management Manage projects of high complexity, including with novel modalities, all of which are enabled by a collaboration with a Flagship platform company. Thinks strategically at the asset and portfolio level. Manage directly at least 1 program and manage/mentor other program managers supporting the portfolio. Actively managing the risks, issues, resources, constraints and stakeholders across a portfolio of projects under their remit. Work with the project team to develop the integrated development plan. Enable transparent and candid communication across the team and to leadership. Relentlessly ensure the execution and tracking of critical activities for project teams. Bring high energy and team spirit that leads to a highly functioning team. Work closely with the project/program managers to ensure teams are operating within the agreement and to ensure the scientific/operations perspectives are brought to the negotiations. Strategic Partnership Development: Understand the partner's business objectives and how the companies align. Build strong relationships with key stakeholders, including Flagship platform companies . Participate in and represent the voice of the PM functions in structuring partnership agreements and in ensuring alignment of goals, expectations, and deliverables. Cross-functional Collaboration: Collaborate closely with internal stakeholders, including program teams, leadership, business development, legal, and finance teams, to ensure alignment of objectives and smooth execution of partnership goals and activities. Facilitate effective knowledge transfer between partner organizations and internal teams, fostering a culture of innovation and shared learning. Coordinate joint projects, meetings, and workshops, promoting active collaboration and synergy among cross-functional teams. Market and Competitive Analysis: With assistance from Portfolio Analytics team, stay up-to-date on the latest industry trends, market dynamics, and competitive landscape in relation to the alliance. Analyze market data and competitor activities to identify potential opportunities and threats. Provide strategic insights and recommendations to senior management regarding potential partnership initiatives and market expansion strategies PROFESSIONAL EXPERIENCE & QUALIFICATIONS Scientific degree plus one advanced degree (MS, MBA or PhD.) 8+ years of direct program management experience. 8+ years' experience in a drug discovery development field or scientific functional experience 6+ years early drug development Program Management experience Scientific/research background, preferably with experience in Metabolic, Cardiovascular, and/or renal disease area(s) Experience in multiple modalities (e.g., RNA-based therapies, biologics/antibodies, small molecule, etc.) Strong understanding of the biopharmaceutical landscape, including key players, emerging trends, and technological advancements. Demonstrated ability to work effectively with cross-functional teams and manage multiple projects simultaneously. Ability to work onsite in Cambridge MA at least 4 days per week experience across the discovery and development lifecycle would also be great. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $204,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

What if… you could pioneer a new approach to designing life's most essential molecules? FL116, backed by Flagship Pioneering, is an early-stage biotechnology company transforming the way biomolecules are synthesized. Our innovative platform has the potential to transform the way these critical research, diagnostic, and therapeutic tools are manufactured. We are seeking passionate problem solvers ready to make a profound impact on biotechnology and therapeutic innovation. Position Summary: We are seeking a motivated and creative Research Associate to join our team focused on protein expression, purification, and innovation. The successful candidate will contribute to the production, purification, and functional characterization of recombinant proteins supporting our research and development efforts. This is an exciting opportunity to join a growing interdisciplinary team and help establish core protein capabilities for a breakthrough synthesis platform. Key Responsibilities: Express recombinant proteins in cell-free, bacterial, and yeast systems, in bulk and at high throughput. Purify proteins using chromatographic techniques such as affinity (Ni-NTA, GST), ion exchange, and size exclusion chromatography Analyze protein samples using SDS-PAGE, Western blotting, BCA assays, and other biochemical methods Develop and optimize activity and characterization assays for purified proteins, both in bulk and at high throughput Maintain accurate and detailed lab records, including batch records and experiment documentation Assist in troubleshooting expression or purification challenges and optimizing protocols Prepare buffers and reagents, maintain reagent stocks, and ensure high laboratory standards Collaborate closely with team members to achieve project goals and timelines Comply with lab safety protocols and best practices in protein handling and biohazard management Qualifications: Bachelor's degree in Biochemistry, Molecular Biology, or related field with 2+ years of relevant laboratory experience Hands-on experience with molecular biology and protein techniques (academic or industry settings) Preferred Qualifications: Experience with cell-free and cell-based protein expression Strong analytical and organizational skills with attention to detail Ability to manage multiple tasks, work independently, and thrive in a collaborative team environment Familiarity with lab information management systems (LIMS), electronic lab notebooks (ELNs), or related data-management tools Enthusiasm for learning and optimizing new techniques in a fast-paced, innovative environment Who You Are Innovative Pioneer: You thrive in breaking new ground scientifically and are passionate about leveraging protein biochemistry to create transformative technologies. Collaborative Contributor: You excel in cross-functional teams, readily share expertise, and value the input of colleagues. Inventive Problem Solver: You proactively identify challenges and rapidly ideate creative solutions. Mission-Driven Individual: You are driven by an ambition to fundamentally change how biomolecules are synthesized and to meaningfully impact human health and biotechnology. More About Flagship Pioneering Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, generating billions in value. Flagship companies are known for addressing humanity's most pressing challenges and advancing innovative solutions with global impact. We are an equal opportunity employer and are dedicated to building diverse and inclusive teams. If you have some of the qualifications listed above but not all, we still encourage you to apply. We value passion, experience in many forms, and unique backgrounds. Come pioneer the future with us. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $65,000 - $93,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL116 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL116's good faith estimate as of the date of publication and may be modified in the future.

Mirai Bio, Inc is a Flagship backed, privately held biotechnology company on a mission to transform the current approach to information molecule therapeutics to unlock their full therapeutic potential. In recent years, we have begun to experience the power of information molecules in treating historically undruggable diseases and in designing therapies with unprecedented turnaround times. Mirai's platform integrates nanoparticle development with world-class informatics technologies and a novel pipeline of experimentation and discovery to drive a new generation of highly effective, therapeutically relevant information molecule therapies. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! Mirai was founded by Flagship Pioneering. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. The current Flagship ecosystem comprises 37 transformative companies, including: Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture, and Sana Biotechnology (NASDAQ: SANA). The Role Mirai Bio is seeking a highly talented individual to design, implement, and deploy novel ML approaches to optimize in vivo therapeutic delivery vehicles. They will work cross-functionally to build the computational tools necessary to identify and test therapeutic candidates to enable Mirai's next generation genomic medicines. The successful candidate will engineer scalable ML platforms and pipelines to overcome limitations of current nucleic acid delivery approaches and will have a strong understanding of targeted information molecule delivery. A successful candidate will have strong familiarity with production-grade ML systems, active learning, and experience working with chemoinformatic libraries. The candidate will also be expected to collaborate extensively with experimental and infrastructure teams. Key Responsibilities Design, build, and deploy production-grade ML models for optimization of lipid nanoparticle (LNP) formulation, synthesis, and in vivo performance. Develop and implement scalable software best practices for uncertainty quantification, ensuring models are reliable for real-time decision-making. Engineer robust data pipelines to integrate multi-fidelity datasets (in silico and in vivo) to accelerate data-driven discovery of novel LNPs Collaborate with computational scientists to translate research models into maintainable, efficient software that identifies design pathways for LNPs that achieve targeted functional properties Work with infrastructure and automation teams to architect and streamline real-time data transfer between predictive models and experimental platforms Partner with experimental teams to drive iterative design-make-test-analyze (DMTA) cycles Communicate findings to stakeholders and leadership through written reports and technical presentations. Professional Experience & Qualifications PhD or Master's in Computer Science, Applied Mathematics, Bioengineering, Chemical Engineering, or a related quantitative field with a strong ML and Software Engineering focus. 4+ years of experience developing and deploying ML models in a production environment within industry and/or academic settings. Strong experience with uncertainty quantification, active learning, and Bayesian Optimization in drug delivery, materials science, or related fields. Proficiency in ML frameworks (PyTorch/TensorFlow/JAX) and the Python data science ecosystem. Demonstrated experience with MLOps principles (version control, CI/CD, monitoring) and hands-on experience with cloud computing infrastructure (e.g., AWS, GCP, Azure) to accelerate model training, deployment, and inference. Strong independent problem-solving ability and attention to detail. Demonstrated achievement in industry or academia (publications, patents, or successful ML system deployments). Excellent communication and presentation skills for both technical and interdisciplinary audiences. Enthusiasm for working with cross-functional teams of experimentalists, engineers, and computational scientists in a fast-paced, entrepreneurial environment. Preferred Qualifications Hands-on experience building and managing ML packages. Experience with ML experiment tracking platforms (e.g. MLflow, Weights & Biases) Familiarity with API development and microservices for integrating ML models into experimental workflows. Background in drug delivery, lipid chemistry, or nanoparticle formulation. ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-LD1 The salary range for this role is $96,000 - $156,750. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Mirai Bio currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Mirai Bio's good faith estimate as of the date of publication and may be modified in the future.

What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner? Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines' approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. Position Summary: The Clinical Development Lead (Medical Director or Senior Medical Director level) is a Physician-Scientist who plays a pivotal role on Pioneering Medicines (PM) project teams by driving the successful transition of programs from research into early clinical development. Reporting to the SVP of Project Leadership and Development (or a senior Clinical Development Leader), this role contributes to shaping clinical strategies that span from candidate discovery to human proof-of-concept (hPOC). As a core member of cross-functional teams, the Clinical Development Lead is responsible for crafting and integrating the target product profile and clinical development plans in alignment with research, translational, nonclinical, regulatory, and strategic priorities. This individual will also support program operations, resource planning, and interactions with internal governance and external partners. The role is ideal for an individual passionate about translating cutting-edge science available from across the Flagship Pioneering ecosystem of companies into innovative medicines through rigorous, thoughtful, and collaborative development planning. This role can be onsite at our Cambridge MA site (4 days onsite per week) or remote for candidates outside a 30-mile radius from Cambridge MA. Responsibilities: Lead the design of early clinical development plans (through hPOC) for PM programs, in alignment with the Target Product Profile (TPP) Collaborate closely with the senior clinical leaders, Project Leaders, Research, Strategy, and external advisors/KOLs to define and refine clinical hypotheses and development strategies. Integrate clinical plans with translational, nonclinical, and regulatory development strategies to enable seamless progression from exploratory studies to FIH trials. Partner with Research teams-including Pharmacology, Translational Sciences, and Nonclinical Development-to align research outputs with clinical objectives. Work with the Strategy Group to ensure clinical plans support the TPP and the overall program value proposition. Incorporate regulatory input, operational feasibility, and real-world data to ensure robust and executable development strategies. Collaborate with Project Management to develop integrated timelines, resource forecasts, and budget assumptions for incorporation into NewCo planning. Support the preparation and delivery of key materials for internal governance forums and Joint Steering Committees (JSCs) with external partners. Identify and address development risks and bottlenecks proactively; drive resolution across functional interfaces. Promote a culture of scientific rigor, accountability, agility, and open collaboration within project teams. Enhance cross-functional integration by facilitating communication, alignment, and shared ownership of development goals. Qualifications: Physician Scientist: MD or MD with PhD with a robust scientific background 3+ years or more of post-graduate/post-residency experience in industry or academic clinical research. Medical residency and/or subspecialty fellowship training highly preferred. Strong understanding of early clinical development and translational medicine, mechanisms of disease, and patient care paradigms in relevant therapeutic areas (oncology, immunology and/or metabolic diseases preferred) Demonstrated excellence in scientific rigor, operational decision making, risk mitigation, and innovation. Proven leadership and effective communication skills, with the ability to collaborate and convey strategic implications to diverse stakeholders. Excellent oral, written, and presentation skills for engaging stakeholders and fostering teamwork. Strong strategic thinking and critical thinking skills for identifying and addressing bottlenecks while optimizing cross-functional processes. Proactive and adaptable in demanding environments, with an operational mindset to improve efficiency and achieve strategic goals. About Flagship Pioneering: Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $205,000 - $335,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

Founded through Flagship Pioneering's venture creation engine, Terrana Biosciences is a cutting-edge agricultural biotechnology company developing innovative RNA-based products to address global agricultural challenges. We are committed to advancing sustainable farming solutions through precision technologies that ensure environmental safety and regulatory compliance. THE ROLE We are seeking a skilled and strategically minded Senior Data Infrastructure Engineer to design, implement, and maintain scalable data systems that support our growing scientific and operational needs. This role will focus on building platform-agnostic, cloud-native infrastructure-primarily in AWS-that underpins key scientific software such as Benchling, ticketing systems, analytics platforms, and high-throughput lab workflows. You will partner closely with bioinformatics, ML/AI & software, and lab operations teams to ensure our data is structured, accessible, and reliable for both routine and high-volume analyses. You'll play a pivotal role in transforming how we manage and leverage scientific data-helping us drive innovation, increase data integrity, and future-proof our data systems. This is a unique opportunity to contribute to meaningful science with cutting-edge infrastructure and a mission-driven team. KEY RESPONSIBILITIES Design, build, and maintain relational and non-relational databases in AWS (RDS, Redshift, DynamoDB, etc.) Lead data model architecture for scientific workflows, ticketing systems, and knowledge platforms Lead technical consulting engagements with LIMS experts at the cutting edge of biotechnology to enable high-throughput workflows and analytics Develop and manage data pipelines for ingesting, cleaning, and transforming lab and operational data Implement and enforce data governance, security, and access control best practices Collaborate cross-functionally with software engineers, ML/AI scientists and domain scientists to ensure performance and alignment with scientific tools (e.g., Benchling) Monitor, troubleshoot, and optimize database performance and resource usage Document and automate standard procedures for system maintenance, updates, and data access Leverage generative AI tools (e.g., Cursor, GitHub Copilot, or custom LLMs) to accelerate scripting, automate documentation, improve query generation, or enhance system monitoring and diagnostics PROFESSIONAL EXPERIENCE & QUALIFICATIONS Bachelor's degree in Computer Science, Information Systems, Bioinformatics, or a related field Master's degree in a technical field or equivalent professional experience in cloud-based data infrastructure or scientific computing highly preferred 4+ years of experience in database administration, data engineering, or infrastructure roles Deep experience with AWS cloud services, including RDS, Athena, S3, and IAM Experience modeling laboratory workflows within a LIMS, including change management and training of users Experience as an information management system administrator or owner, Benchling preferred Proficient in SQL, data modeling, ETL/ELT workflows, and interacting with APIs Familiarity with version control, CI/CD, and infrastructure-as-code tools (e.g., Terraform, CloudFormation) 2+ years of experience with Bioinformatics workflow management tools, Nextflow preferred Strong analytical and problem-solving skills Excellent communication skills and a collaborative mindset Experience in a life sciences or biotech environment preferred Exposure to Smartsheet preferred Familiarity with scientific data standards and FAIR principles preferred Scripting experience (Python, Shell) for automation and data transformation preferred Experience applying generative AI tools to support infrastructure automation, data engineering, or operational tooling preferred Interest in emerging AI-native workflows to enhance data and platform productivity preferred LOCATION: Cambridge, MA or Durham, NC ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TL1 The salary range for this role is $108,000 - $148,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Terrana Biosciences, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Terrana Biosciences, Inc.'s good faith estimate as of the date of publication and may be modified in the future.

ABOUT PROFOUND THERAPUETICS ProFound Therapeutics is pioneering the discovery of the expanded human proteome to unlock a new universe of potential therapeutics. By integrating multi-omics, advanced computation, and translational biology, we aim to reveal and characterize thousands of previously uncharted proteins and systematically explore their role in health and disease. Summary We are seeking a highly skilled Proteomics Bioinformatician with deep expertise in computational data analysis for next-generation mass spectrometry technologies, quantitative proteomics pipelines and proteogenomics. The ideal candidate will develop, optimize, and implement workflows for processing large-scale proteomic datasets, and implement automated MS platforms. Key Responsibilities Develop, implement, and maintain bioinformatics pipelines for MS-based proteomics data (i.e. DDA, DIA, PRM, ion mobility separation) Integrate and analyze large-scale datasets from platforms including Orbitrap instruments, tims TOF, and next-generation DIA. Build pipelines for data QC, normalization, feature alignment, identification, quantification, and downstream statistical analysis. Apply and develop statistical models, machine-learning methods, and visualization tools using Python and R. Automate whole data processing workflows (e.g., Nextflow) and build reproducible analysis modules. Collaborate with experimental teams to refine study design, troubleshoot MS data, and interpret results. Produce comprehensive, well-documented code and reports for internal and external stakeholders. Stay up to date with emerging proteomics tools, algorithms, and quantitative strategies. Required Qualifications Master's w/ 4+ YOE or PhD in Bioinformatics, Computational Biology, Proteomics, Computer Science, or a related discipline. Demonstrated expertise in mass spectrometry proteomics data analysis, with experience using tools such as FragPipe, DIA-NN, Spectronaut/Spectromine, Skyline. Strong programming experience in Python and R for scientific computing, statistics, and visualization (e.g., NumPy, pandas, SciPy, scikit-learn, ggplot2, dplyr, tidyverse). Hands-on experience with statistical analysis, differential expressions, FDR control, PTM analysis, and high-dimensional data processing. Comfortable working with large, complex datasets and high-performance or cloud computing environments. Familiarity with MS data formats, prediction models and conversion tools. Excellent communication skills and ability to collaborate across computational and experimental teams. Proven ability to write clean, reproducible, well-documented code. VALUES & BEHAVIORS We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidate. We recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $115,000 - $165,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. ProFound Therapeutics, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on ProFound Therapeutics, Inc.'s good faith estimate as of the date of publication and may be modified in the future.

Introduction Flagship Pioneering is a company that creates companies, building ground-breaking platforms that change the world. We are a brave and bold organization of creative-thinkers with insurgent mindsets and corporate-builders with incumbent expertise. What if... we could harness the power of data with AI to create breakthroughs and accelerate the creation of new technologies? This is the question that Flagship Pioneering seeks to explore with our latest AI-focused business unit. Our mission is to create, launch, and scale breakthrough ventures that transform how we live, work, and connect. We build companies from zero to one, with cutting-edge AI, exceptional user experience, and a strong vision to pioneer an AI-native future. Position summary As an Operating Principal, you will be the driving force behind a seed to Series A stage software/tech venture, responsible for validating core hypotheses, shaping early product direction, and helping with initial growth. You'll operate as a de facto Head of Operations - combining strategic vision, executional rigor, and entrepreneurial hustle to turn an early concept into a scalable business. This is a hands-on, high-impact role suited for a builder - someone who thrives in ambiguity, loves iterating on products and go-to-market strategies, and has a deep understanding of what it takes to make early-stage companies succeed. Key Responsibilities * Venture building: own the operational and strategic roadmap of an early-stage venture from idea validation through initial launch and traction. * Product-market fit: identify and test hypotheses rapidly through customer discovery, MVP development, and iterative experimentation. * Cross-functional leadership: coordinate with research, engineering, and growth teams to build, optimize and iterate software and tech products. * GTM strategy: define the target market, business model, and acquisition strategy to create scalable, repeatable growth engines. * Talent and culture: recruit early team members and establish the operating culture, processes, and principles. Lead with inspiration and inclusion Qualifications * Experience: 5-10 years in startups, consulting, or venture building - ideally with experience taking software platforms/products from concept to market. * Entrepreneurial mindset: Proven ability to thrive in ambiguity, move fast, and execute with limited resources. * Product fluency: Strong understanding of user research, MVP development, and data-informed decision-making. * Technical literacy: Familiarity with AI technologies (e.g., LLMs, generative AI, or data-driven personalization) and their consumer applications. * Leadership: Exceptional communication and cross-functional leadership, proven track record of building teams. * Bias for action: A pragmatic problem-solver who can balance strategic vision with operational excellence. Why join us * Build from scratch: Be at the forefront of world-shaping innovations and launch entirely new AI-native companies from scratch. * Operate like a founder: Own key decisions, strategy, and execution without the distractions of initial fundraising and administration. * Share the upside: Participate in the equity and long-term success of the ventures you help bring to life. ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $265,000 - $330,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

Who We Are Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Position Summary: We are seeking a hands-on, strategically minded Enterprise Architect / Solutions Architect to design and operationalize Flagship's Enterprise IT Framework-a comprehensive model that connects business processes, systems, data, and governance across the organization. This role will play a central part in aligning enterprise architecture to Flagship's IT strategy, enabling scalable growth, data-driven decision making, and operational efficiency across all business functions. The role combines strategic architecture design with technical execution. The successful candidate will define the enterprise operating model, implement data and application governance practices, and build out a unified architecture that integrates process standardization, systems interoperability, and master data management. Key Responsibilities Enterprise IT Framework Leadership Design, implement, and govern the Enterprise IT Framework-linking business processes, applications, data, and governance mechanisms across the enterprise. Define the Purpose and Objectives of the framework, ensuring all technology investments and operational processes align with Flagship's strategic outcomes. Establish core architectural layers (Business Process, Application & Systems, Data & MDM) and integrate them into the IT operating model. Lead collaboration across IT, Finance, HR, and Operations to align technology with business capabilities and process maturity. Develop an execution roadmap for continuous improvement and scalability. Business Process & Application Architecture Map enterprise business capabilities and identify process standardization and integration opportunities. Build and maintain the application architecture blueprint, defining systems of record, systems of engagement, and integration touchpoints. Support application lifecycle management, including rationalization, consolidation, and modernization initiatives. Partner with business process owners to ensure system design aligns with operational needs and strategic priorities. Data & Master Data Governance Lead the establishment of Master Data Management (MDM) practices and supporting technology. Define data ownership, stewardship, and quality standards across key domains (Employee, Vendor, Customer, Product, etc.). Partner with business and IT teams to enforce consistent data creation, validation, and integration across systems. Support analytics and reporting functions by ensuring data integrity, compliance, and accessibility. Governance & Policy Framework Stand up an IT Governance Committee and associated architecture review processes. Develop and maintain enterprise-wide IT policies, standards, and procedures, covering integration development, security, access, data management, and system lifecycle. Define governance cycles (e.g., Architecture Review Board, annual portfolio reviews) and ensure decisions are documented, auditable, and transparent. Collaborate with cybersecurity and compliance teams to align policies with external standards (SOC, ISO, GDPR, SOX, etc.). Integration & Data Strategy Execution Design and implement system integrations between enterprise platforms and SaaS tools using platforms such as Workato or Power Platform. Ensure integrations are scalable, secure, and aligned with architectural standards. Document data flow and application interdependencies as part of the enterprise data architecture. Strategic Alignment & Continuous Improvement Align enterprise architecture initiatives with Flagship's IT Strategic Goals-operational efficiency, scalability, innovation, and compliance. Define and track metrics and KPIs to measure architectural maturity, integration efficiency, and governance compliance. Continuously assess and optimize architecture components through a structured Assess → Design → Implement → Govern → Optimize cycle. Qualifications Required Experience architecting and implementing enterprise frameworks that integrate processes, applications, and data. Proven ability to translate business strategy into executable technology roadmaps. Strong working knowledge of enterprise systems (ERP, HCM, MDM) and cloud technologies. Hands-on experience with integration platforms (e.g., Workato). Familiarity with governance structures and standards development (e.g., ITSM, SOX, ISO, TOGAF). Excellent communication skills-capable of engaging executives and technical teams alike. Bachelor's or Master's degree in Computer Science, Information Systems, or a related field. Preferred Experience building enterprise frameworks or MDM programs from the ground up. Exposure to life sciences or innovation-driven organizations. Technical certifications (e.g., TOGAF, AWS/Azure Architect, Workato). Demonstrated ability to lead cross-functional governance committees. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto #LI-NM1 The salary range for this role is $76,000 - $104,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

THE COMPANY Extuitive is a Flagship Pioneering-backed startup reimagining product innovation for the AI era. Our mission is to empower entrepreneurs and direct-to-consumer (D2C) brands with AI-driven tools that simplify, accelerate, and scale the launch of new products. Based in Cambridge, MA, we operate like a special ops unit-fast-moving, data-driven, and relentlessly focused on impact. THE ROLE We're seeking a creative, execution-focused Manager of Digital Marketing to build and optimize our full-funnel growth engine from the ground up. You'll own demand generation, paid acquisition, growth experiments, and martech infrastructure. This is an opportunity to shape our digital strategy, influence product-market fit, and drive exponential customer acquisition for AI-powered SaaS tools. KEY RESPONSIBILITIES Digital Marketing Strategy & Execution Develop and oversee multichannel paid campaigns (Meta, TikTok, Google Search/Display, YouTube) Establish and manage awareness, acquisition, and onboarding funnels Build and iterate growth loops (referral programs, virality features) Demand Generation & Lead Funnel Optimization Design, launch, and test B2C campaigns targeting Shopify merchants and e-commerce brands Optimize cost-per-acquisition (CPA), customer lifetime value (LTV), and conversion rates through data-driven experiments Implement automated lead nurturing workflows using email, chat, and retargeting sequences Go-to-Market (GTM) Campaigns Partner with product, content, and sales teams to create and execute launch playbooks for new AI features Define target segments, messaging frameworks, and launch timelines Analyze post-launch performance and iterate rapidly Analytics & Martech Infrastructure Set up and maintain analytics stack (GA4, Mixpanel, HubSpot, GEO or equivalent) Track and report key metrics (CPL, MQL-to-SQL conversion, ROAS, churn) Develop dashboards and playbooks to inform strategic decisions Experimentation & Optimization Lead A/B and multivariate tests on landing pages, ad creatives, and email flows Prioritize test roadmap based on impact vs. effort Document learnings and scale winning experiments Team Leadership & Collaboration Grow and mentor a team of performance marketers and lifecycle specialists Align cross-functional teams (product, design, engineering, sales) on marketing initiatives Present regular updates to executive leadership PROFESSIONAL EXPERIENCE & QUALIFICATIONS 6+ years of marketing experience focused on digital channels and go-to-market strategies for software/SaaS and consumer brands Proven track record developing and executing multi-channel digital campaigns (SEO, SEM, social media, email, content marketing, web analytics) that drive engagement and ROI Expert in paid acquisition & demand generation on e-commerce platforms (e.g., Shopify), including search ads, social ads (Meta, LinkedIn), programmatic DSPs, and retargeting workflows Experience with GEO (generative engine optimization) Proficient with marketing automation & CRM tools (e.g., HubSpot, Marketo, Salesforce Pardot) to architect scalable, personalized customer journeys Strong analytical abilities in Excel and BI platforms (Looker, Tableau) to conduct CAC/LTV calculations, cohort analyses, and funnel optimization Skilled at structuring digital channel partnerships, from platform integrations to affiliate and influencer programs, to expand reach and acquisition Hands-on with go-to-market & product-led growth campaigns, aligning marketing and product for successful launches Startup & early-stage SaaS background preferred, thriving in fast-paced, ambiguous environments Exceptional communicator & leader, with proven presentation, project-management, and cross-functional team coordination skills Advanced PowerPoint proficiency for crafting compelling performance reports and executive decks Creative thinker passionate about innovation, consumer-trend spotting, and applying generative AI to marketing initiatives ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $121,000 - $159,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Extuitive, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Extuitive, Inc.'s good faith estimate as of the date of publication and may be modified in the future. #LI-MB1

Our start-up is building a novel chemical discovery platform to reshape how we develop formulations at the molecular level. By combining artificial intelligence with a cutting-edge laboratory discovery pipeline, our interdisciplinary team will chart an unexplored chemical landscape, enabling breakthroughs in drug delivery, agrichemical formulation, and safe, high-performance industrial chemicals. Our company is backed by Flagship Pioneering, a biotechnology origination company that has founded and developed over 115 scientific ventures over the past 25 years. Flagship Pioneering is dedicated to the development of an ecosystem of first-in-category life sciences companies, resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. THE ROLE We are seeking a motivated ML Scientist to lead the predictive pipeline of a lab-in-the-loop platform for novel chemistry. You will define and implement models that reason through the physical rules that govern chemistry to predict the properties of physiochemical interactions at the molecular level. The ideal candidate is eager to take the lead on building a chemistry discovery platform from scratch and be the team's computational visionary. KEY RESPONSIBILITIES Develop models that predict phase behaviors and physiochemical properties of chemical mixtures across temperature, hydration, and concentration gradients Build a generative “lab-in-the-loop” modeling pipeline, that incorporates human input of the chemical formulation scientist as well as experimental feedback and proposes the next set of experimental samples to be tested in the wet lab Build on top of next-generation chemistry ML methods, such as chemical LLMs, reaction prediction, and electronic structure methods like DFT Own the data flow pipeline, including definition of data standards and processing, data distribution analysis, and visualization to guide the team and inform decision-making processes PROFESSIONAL EXPERIENCE & QUALIFICATIONS PhD (or equivalent experience) in machine learning, computational chemistry, organic chemistry, chemical engineering, materials science, or related field Strong experience in building, training, and validating ML models in chemistry, material science, or related domains Knowledge of fundamentals of chemical properties is essential Proficiency in Python-based deep-learning frameworks (e.g. torch, pytorch lightning), ML logging software (e.g. MLFLow, WandB), relevant scientific libraries for chemistry (e.g. RDKit), and hyper-parameter optimization (e.g. Optuna) Ability to set up and maintain python compute environments Strong code organization and reproducibility work ethics and usage of git-based workflows Familiarity with cloud/HPC frameworks (e.g. aws, azure), containerization (e.g. docker), and batch compute Experience handling large, noisy experimental datasets Strong team player: ability to communicate and work hand-in-hand with chemists, lab scientists, and operational team members Experience with DFT and molecular dynamics tools preferred Experience in Bayesian optimization, active learning, reinforcement learning preferred Prior work on lab-in-the-loop platforms or early-stage teams preferred Knowledgeable in thermodynamics, statistical mechanics, and hydrogen-bonding interactions; familiarity with phase-diagram analysis preferred LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TL1 The salary range for this role is $132,000 - $209,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL118 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL118's good faith estimate as of the date of publication and may be modified in the future.

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Role Summary: The Project Coordinator plays a critical enabling role within BioMedicines, supporting Flagship-style operations that emphasize speed, clarity, and disciplined execution. This role helps keep teams aligned across a highly matrixed, global organization by coordinating projects, meetings, and shared information. The Project Coordinator acts as an operational connective tissue-reducing friction, increasing transparency, and enabling leaders and teams to focus on value creation. This individual needs to take the initiative to drive issues and actions forwardindependently to enable results. Key Responsibilities Program & Portfolio Enablement • Support cross-functional programs by tracking action items, milestones, and key decisions in a lightweight, execution-focused manner. • Ensure clear follow-up and accountability coming out of leadership, program, and governance meetings. • Help maintain rhythm across core operating forums (program reviews, leadership meetings, Flagship touchpoints). Meeting Coordination & Operating Cadence • Schedule and coordinate meetings to support the team being cognizant of global time zones, balancing speed with respect for team capacity. • Manage recurring operating and governance meetings, including agenda preparation, material readiness, and post-meeting action tracking. • Partner with meeting owners to ensure meetings are purposeful, decision-oriented, and well-documented. SharePoint & Knowledge Management • Maintain BioMedicines SharePoint as a single source of truth aligned with Flagship operating norms. • Ensure materials are current, clearly structured, and easy to navigate (programs, governance, decision logs, reference materials). • Support disciplined document hygiene, version control, and archiving. Cross-Functional & Global Team Support • Serve as a trusted operational partner to program teams, functional leaders, and Flagship stakeholders. • Support onboarding by enabling fast access to systems, documents, and ways of working. • Facilitate coordination across R&D, operations, corporate functions, and external partners. Continuous Improvement • Identify opportunities to simplify processes, reduce overhead, and improve information flow. • Help implement practical tools, templates, and working norms consistent with Flagship's lean operating model. Qualifications & Experience • 3-5 years of experience in project coordination, operations, or program support within biotech, life sciences, or similarly fast-moving environments. • Experience supporting highly matrixed teams and senior leaders. • Strong proficiency with SharePoint and Microsoft 365 (Outlook, Teams, PowerPoint, Excel). • Comfort working with ambiguity and evolving priorities. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-NM1 The salary range for this role is $88,000 - $121,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? Montai Therapeutics is a privately held, biotechnology company focused on harnessing AI to decode untapped diverse chemistry to develop breakthrough oral medicines that can address persistent unmet needs in chronic disease. With our CONECTA™ platform, Montai has built the world's leading foundation models for decoding the complex language between nature's bioactive chemistry and human biology - supercharging the drug discovery process with unprecedented optionality and predictability. The company has curated and annotated a collection of over 1B Anthromolecules™ and Anthrologs™, which are derived from molecules humans have chronically consumed in food, supplements and herbal medicines. This has enabled efficient access to chemistry with vast untapped structural diversity and the potential to selectively and precisely modulate complex biology. Montai is rapidly advancing a pipeline of first-in-class oral medicines for validated biological pathways in inflammation and immunology - focused on biologic replacements and historically difficult to drug transcription factors. Position Summary: We are looking for an experienced Head of Clinical Development, reporting to our Chief Executive Officer, to have overall accountability for the development and implementation of small molecule clinical programs in the therapeutic areas of immunology/inflammation at Montai Therapeutics. We are seeking a highly motivated, collaborative, results-oriented individual with the creativity, resourcefulness, and flexibility to excel in our growing organization. Specifically, the Head of Clinical Development will play a pivotal role in driving the successful transition of programs from research to clinical development and will contribute to shaping the clinical strategies that span from candidate discovery to human proof-of-concept. As a leader of our clinical development strategy, this role is responsible for crafting and integrating clinical development plans in alignment with research, translational, nonclinical, regulatory and strategic priorities. This individual will also ultimately oversee those responsible for supporting program operations, resource planning, and interactions with internal governance and external partners. This role is ideal for an experienced individual passionate about translating cutting-edge science into innovative medicines through rigorous, thoughtful and collaborative development planning and execution. Key Responsibilities: Develop programmatic clinical strategy; oversee implementation of clinical programs in line with the clinical strategy and ensure patient safety and data integrity Collaborate closely with Project Leaders, Research, Leadership, and external advisors/KOLs to define and refine clinical hypotheses and development strategies. Integrate clinical plans with translational, nonclinical, and regulatory development strategies to enable seamless progression from exploratory studies to FIH trials. Drive and/or oversee the design, execution, analysis, interpretation, and reporting of clinical studies, both early and more advanced, in collaboration with R&D team members, in a matrixed and highly collaborative team environment Incorporate regulatory input, operational feasibility, and real-world data to ensure robust and executable development strategies. Serve as a Medical Monitor for early (clinical pharmacology, including first in human, DDI, proof of mechanism/concept) and/or more advanced clinical studies; may serve as Project Team Leader for clinical stage programs Assess trade-offs and build alignment with team members to enable informed programmatic decision-making Support development and implementation of program biomarker plans and ensure successful implementation at study site(s) Lead/author clinical portions of regulatory submissions and responses to regulatory agency questions; as appropriate, serve as a company representative for regulatory interactions Identify and address development risks and bottlenecks proactively; drive resolution across functional interfaces. Oversight of growing internal and external clinical operations functions and support, including cross-functional leadership and collaboration with quality, CROs, regulatory, and medical writing teams. Required Experience: M.D. or Ph.D., Ph.D. with 8+ years of relevant experience in biopharmaceutical industry, including significant small molecule drug development experience Educational background in a relevant scientific discipline (e.g., biology, biochemistry, immunology) and advanced degree(s), including as Doctor of Medicine and post-graduate medical or scientific training; specific therapeutic experience in immunology/inflammation Prior experience as a functional leader (e.g., early clinical development, clinical pharmacology, translational/experimental medicine) Broad understanding of biopharmaceutical drug development, including working knowledge of relevant ICH and GCP guidelines and regulations Proficiency in developing and nurturing key partnerships and collaborations with external parties, including investigators, KOLs, CROs, and the broader scientific community (including academia, governmental, or nonprofit organizations), as well as internal discovery and preclinical functions Record of significant and successful contributions to regulatory submissions, including INDs/CTAs, and regulatory agency interactions Experience managing collaborations with consultants, pharmaceutical partners, CROs, and other external organizations is desirable Aptitude in serving as a subject matter expert and mentor across the organization Desired Skills & Competencies: Excellent written and oral communication skills Experience delivering effective presentations to both technical and non-technical audiences Proven leadership skills, with the ability to collaborate and convey strategic implications to diverse stakeholders. Strong strategic thinking and critical thinking skills for identifying and addressing bottlenecks while optimizing cross-functional processes. Proactive and adaptable in demanding environments, with an operational mindset to improve efficiency and achieve strategic goals. Location: Cambridge, MA More About Flagship Pioneering Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $50B in aggregate value. To date, Flagship has deployed over $2.2B in capital toward the founding and growth of its pioneering companies alongside more than $18B of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX). Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $360,000 - $415,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Montai Therapeutics currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Montai Therapeutics's good faith estimate as of the date of publication and may be modified in the future.

Our start-up is building a novel chemical discovery platform to reshape how we develop formulations at the molecular level. By combining artificial intelligence with a cutting-edge laboratory discovery pipeline, our interdisciplinary team will chart an unexplored chemical landscape, enabling breakthroughs in drug delivery, agrichemical formulation, and safe, high-performance industrial chemicals. Our company is backed by Flagship Pioneering, a biotechnology origination company that has founded and developed over 115 scientific ventures over the past 25 years. Flagship Pioneering is dedicated to the development of an ecosystem of first-in-category life sciences companies, resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. THE ROLE We are seeking an experienced formulations chemist to lead the design, strategy, and implementation of a high-throughput chemical formulation and testing pipeline. This position will focus on building a rapid and evolving system for manufacturing chemical mixtures and measuring the physiochemical properties of these mixtures at various temperatures and levels of hydration. This position will also coordinate heavily with a Machine Learning Lead to integrate the bench top pipeline output with the training and output of a predictive model for formulation chemistry. The ideal candidate will have a strong background in organic chemistry, high-throughput chemical screening, spectroscopy, calorimetry, and other advanced techniques for the physical characterization of chemicals. KEY RESPONSIBILITIES * Manufacturing formulations * Design and implement a scalable high-throughput workflow for generating diverse chemical mixtures. * Rigorously catalog known formulations for comparison to newly developed and untested formulations. * Establish automated liquid handling, dosing, and mixing protocols to ensure reproducibility and throughput. * Develop standard operating procedures (SOPs) for safe handling, storage, and disposal of raw materials and formulations. * Collaborate with upstream ML lead on formulation design workflows that maximize our canvassing of chemical property space and support the generation of high-quality, broad-coverage training data. * Characterizing formulation properties * Assess viscosity, solubility, and other physiochemical features under different hydration and temperature conditions. * Apply spectroscopy (UV-Vis, IR, fluorescence) to quantify molecular interactions and stability. * Use calorimetry and thermal gravimetric analysis to measure thermodynamic and thermal stability profiles of formulations. * Develop and validate assays to track long-term stability and degradation of formulations. * Screening formulation-cargo interactions * Design assays to evaluate compatibility of formulations with diverse small molecules, peptides, proteins, and nucleic acids. * Measure cargo protection and stability (e.g., aggregation, precipitation, degradation) under varied conditions. * Integrate biophysical characterization methods (DLS, CD, IR, LCMS) to assess cargo-formulation interactions. PROFESSIONAL EXPERIENCE & QUALIFICATIONS * Ph.D. in Organic Chemistry, Physical Chemistry, Chemical Engineering, Materials Science, or a related field + 5 years of experience (including 2 years of industry at minimum). Education may count towards years of experience. * Extensive hands-on experience with formulation chemistry, high-throughput chemical screening, or analytical method development. * Demonstrated expertise in chemical characterization techniques such as spectroscopy (UV-Vis, IR, NMR, fluorescence), calorimetry (DSC, ITC), and rheology. * Proven ability to characterize physicochemical properties of complex mixtures under varying environmental conditions. * Strong background in designing and executing high-throughput or automated experimental workflows. * Committed team player with the ability to communicate and work collaboratively with ML scientists, lab scientists and operational team members. * Prior leadership or team management experience preferred. * Experience integrating benchtop experimental data into machine learning pipelines or predictive modeling workflows preferred. * Strong understanding of thermodynamics, kinetics, and intermolecular interactions in multicomponent systems preferred. * Familiarity with high-throughput robotics, automation platforms, or liquid handling systems for screening of solvents and liquids preferred. * Knowledge of data analysis pipelines, including scripting skills (e.g., Python, R, MATLAB) for handling large experimental datasets preferred. * Exposure to generative AI models for chemical discovery preferred. * Experience working with biomolecules and protein chemistry preferred. * Familiarity with principles of physical chemistry preferred. * Experience in chemistry screening for personal care, nutrition, or aqueous coatings and adhesives preferred. LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TL1 The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL118 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL118's good faith estimate as of the date of publication and may be modified in the future.

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform health care and sustainability? At Flagship Labs 107 (FL107), a Flagship Pioneering-backed stealth biotechnology company, we're pioneering the mastery of protein control: tuning the stability, degradation, and localization, of any protein. By systematically rewriting the rules of protein homeostasis, we're on a mission to target the “undruggable” and treat the “impossible.” Our innovative approach combines novel biology, medicinal chemistry, and AI/ML-powered molecular design, all driven by our unwavering commitment to dramatically improve patient lives. Position Summary: As we advance our platform and progress toward the clinic, we are seeking an exceptional Director of Medicinal Chemistry to lead small molecule discovery efforts across multiple programs. This is a foundational scientific leadership role, ideal for a medicinal chemist who combines scientific rigor, creative drive, and operational acumen to advance first-in-class therapeutics from concept to IND. Reporting to our SVP, Research, the Director of Medicinal Chemistry will establish medicinal chemistry competencies at FL107, working across discovery programs. You will help lead the design and execution of small molecule discovery campaigns at the core of the platform, leveraging DNA-encoded library (DEL) and covalent fragment screening, AI/ML-driven generative chemistry, and structure-based design. Your goal will be to help identify and create novel protein modulators, including heterobifunctional degraders, molecular glues, and other proximity-inducing molecules. You will collaborate closely with biology, computational, and biochemistry teams to integrate new chemotypes into our drug discovery efforts, while managing external chemistry partnerships. This is a unique opportunity to define FL107's chemistry strategy, build the execution engine, and help shape the platform and portfolio of a high-growth company from the ground up. Key Responsibilities: Lead medicinal chemistry activities and strategy across multiple early discovery programs through conception to DC nomination and IND-enabling activities. Drive and design optimization of compounds identified by DEL screening, covalent fragment discovery, and structure/AI-guided approaches. Define and prioritize medicinal chemistry workflows to enable exploration of proximity-inducing modalities such as molecular glues and heterobifunctional molecules. Serve as chemistry lead across cross-functional teams, providing deep insight into SAR, PK/PD, potency, and drug-like properties. Build and manage a highly productive network of CRO partners, ensuring timely execution of synthesis, hit-to-lead, and scale-up activities. Partner with computational scientists to iterate on predictive models and generative design strategies; evaluate and apply in silico compound generation tools. Contribute to and help shape FL107's intellectual property strategy around novel chemical matter and mechanisms. Design, build, and oversee FL107's compound data infrastructure to ensure high-quality, well-curated datasets that power structure-based drug design (SBDD) and machine learning initiatives. Provide leadership, mentorship, and technical direction to a growing internal chemistry team as FL107 scales. Required Qualifications PhD. in Organic or Medicinal Chemistry experience in small molecule drug discovery. Proven track record advancing multiple programs through hit-to-lead and lead optimization; experience nominating development candidates is essential. Demonstrated success working with emerging modalities (e.g., molecular glues, bifunctional molecules, induced proximity) and complex scaffolds. Deep understanding of structure-based drug design, SAR optimization, and balancing key parameters (potency, ADME/PK, physicochemical properties). Comfortable partnering with AI/ML teams and evaluating computational and generative design inputs-outputs. Experience managing distributed CRO teams, external synthesis workflows, and global chemistry partnerships. Strong cross-functional collaboration skills; fluent in communicating with biology, DMPK, IP, and data science stakeholders. Strategic mindset with strong scientific judgment, organizational leadership, and a drive to move with urgency. Excellent communication and synthesis skills, with the ability to present structured updates on complex scientific concepts to technical, non-technical, and executive audiences. Strong analytical skills with the ability to interpret complex datasets and derive meaningful insights. Proven ability to work effectively in a collaborative team environment and manage multiple projects simultaneously. Resourceful problem solver and self-starter. Preferred Qualifications Experience with DEL screening, covalent chemistries, or reactive fragment libraries. Familiarity with designing bifunctional compounds, linker exploration, and ternary complex modeling. Prior experience in building and growing chemistry teams in a start-up or entrepreneurial environment. Strong IP and patent experience; comfort working with legal teams to develop and protect novel chemical matter. Exposure to platform-based discovery environments with multi-program pipelines. What We Offer: Opportunity to lay the scientific foundation of a transformative platform company as an early employee, and to serve as a key contributor to the development of new technologies in the protein degradation field. Custom-tailored role to maximize impactful contributions, professional growth, and scientific interests. Weekly lunches, monthly social events, and community lunchroom with free snacks, cold brew coffee tap, and a vibrant community with scientists and entrepreneurs. A collaborative and inclusive work environment that values diversity and innovation. Access to state-of-the-art facilities and cutting-edge technologies. Values and Behaviors: Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. The salary range for this role is $179,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL107 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL107's good faith estimate as of the date of publication and may be modified in the future.