Director jobs at Flagship Pioneering - 29 jobs

What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner? ABOUT PIONEERING MEDICINES Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. THE ROLE We are seeking a highly motivated and experienced Senior Director of Program Management to join our team. You will be responsible for developing and managing strategically important partnerships with pharmaceutical companies and with other Flagship companies. You will help establish best practices for Pioneering Medicines' existing and future programs. Since we are an entrepreneurial, high growth unit of Flagship, you will work as the Program Manager for at least one program at any given time. This is a high-profile role in our organization and an opportunity to work side by side with our leadership team. KEY RESPONSIBILITIES Program Management Manage projects of high complexity, including with novel modalities, all of which are enabled by a collaboration with a Flagship platform company. Thinks strategically at the asset and portfolio level. Manage directly at least 1 program and manage/mentor other program managers supporting the portfolio. Actively managing the risks, issues, resources, constraints and stakeholders across a portfolio of projects under their remit. Work with the project team to develop the integrated development plan. Enable transparent and candid communication across the team and to leadership. Relentlessly ensure the execution and tracking of critical activities for project teams. Bring high energy and team spirit that leads to a highly functioning team. Work closely with the project/program managers to ensure teams are operating within the agreement and to ensure the scientific/operations perspectives are brought to the negotiations. Strategic Partnership Development: Understand the partner's business objectives and how the companies align. Build strong relationships with key stakeholders, including Flagship platform companies . Participate in and represent the voice of the PM functions in structuring partnership agreements and in ensuring alignment of goals, expectations, and deliverables. Cross-functional Collaboration: Collaborate closely with internal stakeholders, including program teams, leadership, business development, legal, and finance teams, to ensure alignment of objectives and smooth execution of partnership goals and activities. Facilitate effective knowledge transfer between partner organizations and internal teams, fostering a culture of innovation and shared learning. Coordinate joint projects, meetings, and workshops, promoting active collaboration and synergy among cross-functional teams. Market and Competitive Analysis: With assistance from Portfolio Analytics team, stay up-to-date on the latest industry trends, market dynamics, and competitive landscape in relation to the alliance. Analyze market data and competitor activities to identify potential opportunities and threats. Provide strategic insights and recommendations to senior management regarding potential partnership initiatives and market expansion strategies PROFESSIONAL EXPERIENCE & QUALIFICATIONS Scientific degree plus one advanced degree (MS, MBA or PhD.) 8+ years of direct program management experience. 8+ years' experience in a drug discovery development field or scientific functional experience 6+ years early drug development Program Management experience Scientific/research background, preferably with experience in Metabolic, Cardiovascular, and/or renal disease area(s) Experience in multiple modalities (e.g., RNA-based therapies, biologics/antibodies, small molecule, etc.) Strong understanding of the biopharmaceutical landscape, including key players, emerging trends, and technological advancements. Demonstrated ability to work effectively with cross-functional teams and manage multiple projects simultaneously. Ability to work onsite in Cambridge MA at least 4 days per week experience across the discovery and development lifecycle would also be great. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $204,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence builds on Flagship Pioneering's legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio of AI-first companies. As part of Flagship's integrated model of science, entrepreneurship, and capital, it transforms breakthrough ideas into world-changing companies, elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond. THE ROLE The Pioneering Intelligence team at Flagship Pioneering builds the digital and AI foundation that accelerates the creation and growth our companies. We are seeking a Senior Vice President (SVP) - AI & Digital Platform to enable AI tooling across our enterprise, shepherd our AI-native data platform, maintain and evolve the digital backbone of our early stage companies, and lead a world-class technology team though support, empowerment, and accountability. This is a senior leadership role within the Pioneering Intelligence Initiative, offering the opportunity to shape the strategy, execution, and impact of AI across Flagship's ecosystem. As the SVP - AI & Digital Platform, you will be responsible for defining and executing the vision for how AI and digital technologies enable Flagship and its portfolio companies. You will shepherd and deliver the platforms, tools, and infrastructure that power AI-native operations and empower scientific and business teams. This role combines strategic leadership with deep technical expertise, requiring you to operate in highly ambiguous environments, shape long-term direction, and build organizational capabilities that endure. KEY RESPONSIBILITIES * Enable AI tooling and capabilities across scientific and operational workflows. * Architect and implement an AI-native data platform that empowers Agentic AI and AI Modeling teams. * Maintain and evolve the PI Digital Backbone-Flagship's shared infrastructure "starter kit" for new company launches, including compute, shared code, and AI tools. * Support and develop a high-performing, product-minded technology organization. * Partner with portfolio company founders, venture teams, scientific leaders, and functional teams to align and drive adoption of our shared digital strategy. * Develop and communicate strategy for Flagship's AI initiatives internally and externally. PROFESSIONAL EXPERIENCE & QUALIFICATIONS * 15+ years of progressive leadership experience in AI, data platforms, or digital technology, ideally spanning both technology and life sciences. * Demonstrated success in building and scaling platforms that deliver measurable scientific or business outcomes. * Deep expertise in AI, ML, and data architectures, paired with strong product and business acumen. * Proven ability to thrive in highly ambiguous, rapidly evolving environments. * Track record of building and leading diverse, high-performing teams. * Excellent communication and collaboration skills, with the ability to influence at all levels of an organization. Preferred Qualifications * Experience creating or scaling digital platforms in complex or scientific domains. * Familiarity with life sciences R&D workflows and the opportunities for AI-driven acceleration. * Experience with early-stage B2B software product development. * Strong network within the AI and digital innovation ecosystem. WHY PIONEERING INTELLIGENCE? * Lead a bold initiative at the intersection of AI, digital platforms, and pioneering science. * Help define the future of Flagship's digital and AI strategy, impacting multiple portfolio companies. * Collaborate with visionary founders, scientists, and innovators across Flagship's ecosystem. * Build in a supportive, mission-driven culture with access to world-class technical and operational resources. * Competitive compensation and benefits, including equity, commensurate with experience. ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-NM1 The salary range for this role is $325,000 - $450,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Intelligence currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Intelligence's good faith estimate as of the date of publication and may be modified in the future.

What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner? ABOUT PIONEERING MEDICINES Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. THE ROLE We are seeking a highly motivated and experienced Senior Director of Program Management to join our team. You will be responsible for developing and managing strategically important partnerships with pharmaceutical companies and with other Flagship companies. You will help establish best practices for Pioneering Medicines' existing and future programs. Since we are an entrepreneurial, high growth unit of Flagship, you will work as the Program Manager for at least one program at any given time. This is a high-profile role in our organization and an opportunity to work side by side with our leadership team. KEY RESPONSIBILITIES Program Management * Manage projects of high complexity, including with novel modalities, all of which are enabled by a collaboration with a Flagship platform company. * Thinks strategically at the asset and portfolio level. * Manage directly at least 1 program and manage/mentor other program managers supporting the portfolio. * Actively managing the risks, issues, resources, constraints and stakeholders across a portfolio of projects under their remit. * Work with the project team to develop the integrated development plan. * Enable transparent and candid communication across the team and to leadership. * Relentlessly ensure the execution and tracking of critical activities for project teams. * Bring high energy and team spirit that leads to a highly functioning team. * Work closely with the project/program managers to ensure teams are operating within the agreement and to ensure the scientific/operations perspectives are brought to the negotiations. Strategic Partnership Development: * Understand the partner's business objectives and how the companies align. * Build strong relationships with key stakeholders, including Flagship platform companies . * Participate in and represent the voice of the PM functions in structuring partnership agreements and in ensuring alignment of goals, expectations, and deliverables. Cross-functional Collaboration: * Collaborate closely with internal stakeholders, including program teams, leadership, business development, legal, and finance teams, to ensure alignment of objectives and smooth execution of partnership goals and activities. * Facilitate effective knowledge transfer between partner organizations and internal teams, fostering a culture of innovation and shared learning. * Coordinate joint projects, meetings, and workshops, promoting active collaboration and synergy among cross-functional teams. Market and Competitive Analysis: * With assistance from Portfolio Analytics team, stay up-to-date on the latest industry trends, market dynamics, and competitive landscape in relation to the alliance. * Analyze market data and competitor activities to identify potential opportunities and threats. * Provide strategic insights and recommendations to senior management regarding potential partnership initiatives and market expansion strategies PROFESSIONAL EXPERIENCE & QUALIFICATIONS * Scientific degree plus one advanced degree (MS, MBA or PhD.) * 8+ years of direct program management experience. * 8+ years' experience in a drug discovery development field or scientific functional experience * 6+ years early drug development Program Management experience * Scientific/research background, preferably with experience in Metabolic, Cardiovascular, and/or renal disease area(s) * Experience in multiple modalities (e.g., RNA-based therapies, biologics/antibodies, small molecule, etc.) * Strong understanding of the biopharmaceutical landscape, including key players, emerging trends, and technological advancements. * Demonstrated ability to work effectively with cross-functional teams and manage multiple projects simultaneously. * Ability to work onsite in Cambridge MA at least 4 days per week * experience across the discovery and development lifecycle would also be great. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $204,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? Montai Therapeutics is a privately held, biotechnology company focused on harnessing AI to decode untapped diverse chemistry to develop breakthrough oral medicines that can address persistent unmet needs in chronic disease. With our CONECTA™ platform, Montai has built the world's leading foundation models for decoding the complex language between nature's bioactive chemistry and human biology - supercharging the drug discovery process with unprecedented optionality and predictability. The company has curated and annotated a collection of over 1B Anthromolecules™ and Anthrologs™, which are derived from molecules humans have chronically consumed in food, supplements and herbal medicines. This has enabled efficient access to chemistry with vast untapped structural diversity and the potential to selectively and precisely modulate complex biology. Montai is rapidly advancing a pipeline of first-in-class oral medicines for validated biological pathways in inflammation and immunology - focused on biologic replacements and historically difficult to drug transcription factors. Position Summary We are looking for an experienced Preclinical development Program Manager to provide critical support to preclinical/clinical development cross-functional program teams to drive the delivery of program goals. The position will work collaboratively with the program leads, teams, and functional area leads in a fast-paced and exciting environment at the heart of ensuring planning and achievement of our critical corporate goals. This role is focused on enabling teams to advance therapeutic programs from development candidates to First-in-human studies and beyond. This is an exciting and visible role for a highly qualified and motivated individual. The Program Manager is responsible to plan, execute, manage risk, and manage critical paths according to strict deadlines and within budget. This includes engaging resources and coordinating the efforts of team members, third-party organizations where appropriate, and internal stakeholders to deliver program goals according to plan. Accountable to create program team governance to engage cross functional accountability of costs, schedules, scope, resources and track risks of programs and multiple integrated programs. Key Responsibilities will include, but not limited to the following: Support Program Lead to develop and foster productive cross-company relationships to develop, maintain and execute integrated program plans to identify/communicate interdependencies as well as critical path activities for the programs: Analyze program risks and identify impact while developing mitigation strategies, Identify and manage critical path, ensure appropriate program level definition across all stake holders and manage the program from concept to commercialization Monitor the overall progression of portfolio, including progress reports, milestones, key risks to achieving as well as key throughput and cost metrics Creates and executes program work plans and revises as appropriate to meet changing needs and requirements. Mitigates team conflict and communication problems. Motivates team to work together in the most efficient manner. Leverages program management tools to assist in the development of and adherence to established milestones and report status. Own and create appropriate levels of governance to ensure alignment and clear objectives Leads post-project reviews, identify root causes, distill key learnings, and ensure actionable recommendations are implemented and communicated across the program team. Work with Finance to implement and track program budget and forecasts, assist with operational and team meetings and other activities. Act as the source for information regarding the overall progression of the portfolio, milestone achievements, and risk monitoring Support strategic initiatives that enable teams to improve productivity and maintain focus on being an agile organization. Qualifications Bachelor's degree in life sciences or related field. Advanced degree (MS, PhD or MBA) and/or PMP Certification preferred. A minimum of 3+ years of experience in the biopharmaceutical/pharmaceutical industry. Previous experience in immunological therapeutics and small molecules preferred. A minimum of 2+ years of experience in program management of pharmaceutical products focused on small molecule drug preclinical and clinical development Knowledge of biotechnology/pharmaceutical preclinical and clinical development processes Track record of successful leadership, management, and development of multi-disciplinary project management teams. Skills / Capabilities Expertise in Microsoft suite (Program, PowerPoint, SharePoint, Word, Excel, Visio, Outlook). Experience with SharePoint and PM tools. Excellent oral and written communication skills, including presentation and facilitation skills, to effectively inform key updates & issues across all levels of the organization. Ability to work independently and successfully in a fast-paced, results-driven, highly accountable environment with large potential impact. Prioritize and manage multiple tasks simultaneously, integrate cross-functional issues and balance competing priorities effectively. Strong analytical, problem solving and critical thinking skills, including an ability to combine attention to detail with a big picture perspective. Available to travel if/when needed. Values and Behaviors: Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $179,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Montai Therapeutics currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Montai Therapeutics's good faith estimate as of the date of publication and may be modified in the future.

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? Montai Therapeutics is a privately held, biotechnology company focused on harnessing AI to decode untapped diverse chemistry to develop breakthrough oral medicines that can address persistent unmet needs in chronic disease. With our CONECTA platform, Montai has built the world's leading foundation models for decoding the complex language between nature's bioactive chemistry and human biology - supercharging the drug discovery process with unprecedented optionality and predictability. The company has curated and annotated a collection of over 1B Anthromolecules and Anthrologs, which are derived from molecules humans have chronically consumed in food, supplements and herbal medicines. This has enabled efficient access to chemistry with vast untapped structural diversity and the potential to selectively and precisely modulate complex biology. Montai is rapidly advancing a pipeline of first-in-class oral medicines for validated biological pathways in inflammation and immunology - focused on biologic replacements and historically difficult to drug transcription factors. Position Summary We are looking for an experienced Preclinical development Program Manager to provide critical support to preclinical/clinical development cross-functional program teams to drive the delivery of program goals. The position will work collaboratively with the program leads, teams, and functional area leads in a fast-paced and exciting environment at the heart of ensuring planning and achievement of our critical corporate goals. This role is focused on enabling teams to advance therapeutic programs from development candidates to First-in-human studies and beyond. This is an exciting and visible role for a highly qualified and motivated individual. The Program Manager is responsible to plan, execute, manage risk, and manage critical paths according to strict deadlines and within budget. This includes engaging resources and coordinating the efforts of team members, third-party organizations where appropriate, and internal stakeholders to deliver program goals according to plan. Accountable to create program team governance to engage cross functional accountability of costs, schedules, scope, resources and track risks of programs and multiple integrated programs. Key Responsibilities will include, but not limited to the following: Support Program Lead to develop and foster productive cross-company relationships to develop, maintain and execute integrated program plans to identify/communicate interdependencies as well as critical path activities for the programs: * Analyze program risks and identify impact while developing mitigation strategies, * Identify and manage critical path, ensure appropriate program level definition across all stake holders and manage the program from concept to commercialization * Monitor the overall progression of portfolio, including progress reports, milestones, key risks to achieving as well as key throughput and cost metrics * Creates and executes program work plans and revises as appropriate to meet changing needs and requirements. * Mitigates team conflict and communication problems. Motivates team to work together in the most efficient manner. * Leverages program management tools to assist in the development of and adherence to established milestones and report status. * Own and create appropriate levels of governance to ensure alignment and clear objectives * Leads post-project reviews, identify root causes, distill key learnings, and ensure actionable recommendations are implemented and communicated across the program team. * Work with Finance to implement and track program budget and forecasts, assist with operational and team meetings and other activities. * Act as the source for information regarding the overall progression of the portfolio, milestone achievements, and risk monitoring * Support strategic initiatives that enable teams to improve productivity and maintain focus on being an agile organization. Qualifications * Bachelor's degree in life sciences or related field. Advanced degree (MS, PhD or MBA) and/or PMP Certification preferred. * A minimum of 3+ years of experience in the biopharmaceutical/pharmaceutical industry. Previous experience in immunological therapeutics and small molecules preferred. * A minimum of 2+ years of experience in program management of pharmaceutical products focused on small molecule drug preclinical and clinical development * Knowledge of biotechnology/pharmaceutical preclinical and clinical development processes * Track record of successful leadership, management, and development of multi-disciplinary project management teams. Skills / Capabilities * Expertise in Microsoft suite (Program, PowerPoint, SharePoint, Word, Excel, Visio, Outlook). Experience with SharePoint and PM tools. * Excellent oral and written communication skills, including presentation and facilitation skills, to effectively inform key updates & issues across all levels of the organization. * Ability to work independently and successfully in a fast-paced, results-driven, highly accountable environment with large potential impact. Prioritize and manage multiple tasks simultaneously, integrate cross-functional issues and balance competing priorities effectively. * Strong analytical, problem solving and critical thinking skills, including an ability to combine attention to detail with a big picture perspective. * Available to travel if/when needed. Values and Behaviors: Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $179,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Montai Therapeutics currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Montai Therapeutics's good faith estimate as of the date of publication and may be modified in the future.

Operating Principal - Summit PBU THE ROLE Summit, a Pioneering Business Unit within Flagship, is seeking an Operating Principal to help launch and scale our NewCos. You will work across one or more companies, leading operations and strategy, driving corporate development, and partnering closely with scientific leadership to translate breakthrough ideas into impact. This role is ideal for an entrepreneurial leader who thrives in ambiguity, moves seamlessly between science and business, and is energized by building organizations from inception to growth. KEY RESPONSIBILITIES Lead strategy and operational planning in one or more NewCos. Drive corporate development initiatives, including partnerships, financings, and strategic alliances, as well as engagement with Board of Directors and other important stakeholders Engage directly with scientists and company leaders to align technical progress with operational goals. Recruit, develop, and manage high-performing teams across functions. Partner with Flagship central teams (Finance, Talent, Legal/IP, HR) to bring best-in-class infrastructure to each company. Shape and execute operating and long-range plans, ensuring milestones are achieved on time and on budget. Build strong external relationships with investors, partners, and key opinion leaders. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Who you are: You are a dynamic operator and strategist who combines business leadership with scientific fluency. You thrive in fast-moving, entrepreneurial environments and are motivated by building organizations that harness novel science. Qualifications: 10+ years of experience in biotech, pharma, or life sciences strategy/operations; prior management consulting a plus. Proven success in strategic, operational, or corporate development leadership, ideally in early-stage biotech. Strong scientific acumen; able to quickly grasp novel science and translate it into plans and execution. Track record of building and motivating high-performing teams. Skilled communicator, able to influence and inspire across investors, partners, and internal teams. Expert problem solver; can bring order to chaos and iterate quickly to find solutions Entrepreneurial, resilient, and hands-on; able to adapt and execute with urgency; doesn't mind rolling up sleeves and doing what needs to be done to move the ball forward How You Lead: You set a high bar for yourself and others, balancing precision with agility. You are curious, feedback-driven, and focused on constantly learning how to be the best version of yourself. You face challenges with grit and enthusiasm, while fostering collaboration, shared ownership, and pride in collective achievements. EDUCATION Advanced degree in life sciences or business preferred (PhD, MD, MBA, or equivalent experience). LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-JA2 The salary range for this role is $220,000 - $269,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

Operating Principal - Summit PBU THE ROLE Summit, a Pioneering Business Unit within Flagship, is seeking an Operating Principal to help launch and scale our NewCos. You will work across one or more companies, leading operations and strategy, driving corporate development, and partnering closely with scientific leadership to translate breakthrough ideas into impact. This role is ideal for an entrepreneurial leader who thrives in ambiguity, moves seamlessly between science and business, and is energized by building organizations from inception to growth. KEY RESPONSIBILITIES * Lead strategy and operational planning in one or more NewCos. * Drive corporate development initiatives, including partnerships, financings, and strategic alliances, as well as engagement with Board of Directors and other important stakeholders * Engage directly with scientists and company leaders to align technical progress with operational goals. * Recruit, develop, and manage high-performing teams across functions. * Partner with Flagship central teams (Finance, Talent, Legal/IP, HR) to bring best-in-class infrastructure to each company. * Shape and execute operating and long-range plans, ensuring milestones are achieved on time and on budget. * Build strong external relationships with investors, partners, and key opinion leaders. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Who you are: You are a dynamic operator and strategist who combines business leadership with scientific fluency. You thrive in fast-moving, entrepreneurial environments and are motivated by building organizations that harness novel science. Qualifications: * 10+ years of experience in biotech, pharma, or life sciences strategy/operations; prior management consulting a plus. * Proven success in strategic, operational, or corporate development leadership, ideally in early-stage biotech. * Strong scientific acumen; able to quickly grasp novel science and translate it into plans and execution. * Track record of building and motivating high-performing teams. * Skilled communicator, able to influence and inspire across investors, partners, and internal teams. * Expert problem solver; can bring order to chaos and iterate quickly to find solutions * Entrepreneurial, resilient, and hands-on; able to adapt and execute with urgency; doesn't mind rolling up sleeves and doing what needs to be done to move the ball forward How You Lead: You set a high bar for yourself and others, balancing precision with agility. You are curious, feedback-driven, and focused on constantly learning how to be the best version of yourself. You face challenges with grit and enthusiasm, while fostering collaboration, shared ownership, and pride in collective achievements. EDUCATION Advanced degree in life sciences or business preferred (PhD, MD, MBA, or equivalent experience). LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-JA2 The salary range for this role is $220,000 - $269,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

THE ROLE The Associate Director of Portfolio Business Analytics is a key contributor of Product and Partnering organization, a Flagship Pioneering initiative focused on conceiving and developing transformative treatments for patients. We build a portfolio of novel therapeutics by harnessing Flagship's scientific platforms and applying them to serious diseases beyond their current focus areas. Through this approach, we aim to bring the benefits of Flagship's innovation to more patients, faster. This role sits at the intersection of science, strategy, and finance-supporting portfolio decision-making through rigorous analytics, financial modeling, and market evaluation. The successful candidate will combine deep biopharma industry knowledge with advanced financial modeling skills, particularly in valuation and forecasting of pharmaceutical products across therapeutic areas and development stages. The individual will collaborate across R&D, business development, finance, and commercial strategy teams to generate data-driven insights that inform portfolio and investment decisions. KEY RESPONSIBILITIES Financial Modeling & Valuation Develop robust, detailed financial models for Flagship's therapeutic programs and platforms, including revenue forecasts, valuation analyses (DCF, NPV, rNPV), and scenario planning. Translate scientific, clinical, and operational assumptions into quantitative business models. Support capital allocation analyses and portfolio prioritization through rigorous sensitivity and risk-adjusted analyses. Maintain and improve financial models and forecasting frameworks as portfolio complexity increases. Market and Competitive Analytics Conduct comprehensive market landscape analyses using both secondary sources and primary research (e.g., KOL interviews, surveys) to assess unmet needs, competitive dynamics, and market potential. Monitor key trends in relevant therapeutic areas and biopharma markets to inform portfolio strategy. Understand competitive positioning of ongoing and planned Pioneering Medicines programs. Summarize market and competitor insights into clear, concise reports for leadership review. Portfolio Strategy & Governance Support Build and maintain portfolio analytics tools and frameworks to support resource planning, portfolio valuation, and scenario modeling. Prepare high-quality materials and analyses for internal governance and investment committee reviews, including portfolio summaries, risk assessments, and valuation comparisons. Ensure consistent use of financial and operational metrics across programs and functions. Benchmark portfolio and organizational performance against comparable biotech and pharma peers to identify key measures of success. Cross-Functional Collaboration Partner closely with R&D, Competitive intelligence, Finance, Business Development, and Commercial Strategy teams to align scientific and business perspectives in portfolio analytics. Collaborate with data and insights teams to integrate forecasting models with relevant clinical and operational data systems. Serve as an analytical partner to program leads, helping teams understand value drivers, risks, and key decision points. Collaborate with Finance on annual LRP process and output Leadership & Influence Lead cross-functional analytical initiatives. Proactively identify analytical or process improvements to enhance portfolio visibility and decision-making. Champion data-driven and enterprise-level thinking across Pioneering Medicines teams. Operational Excellence Build scalable systems and dashboards to enable efficient portfolio tracking and forecasting. Drive standardization of assumptions, metrics, and templates across portfolio analyses. Complete ad hoc requests and deliver outputs with minimal oversight in a timely manner. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Education (one of the following combinations): Ph.D. in a life science discipline (e.g., Biology, Biomedicine, Chemistry, Pharmacology) with at least 3 years of relevant industry or consulting experience. MBA with a strong quantitative or finance focus (e.g., healthcare management, finance, strategy) with at least 5 years of relevant experience. Master's degree in life sciences, economics, finance, or a related field with at least 5 years of experience. Bachelor's degree in life sciences, economics, finance, or a related field with at least 8 years of relevant experience. Experience: Demonstrated expertise in financial modeling and valuation of pharmaceutical assets and portfolios, including revenue forecasting and risk-adjusted returns. Experience in biopharma investment banking, Big 4 advisory, life science strategy consulting, or corporate/business development in biotech or pharma. Proven ability to perform competitive analysis and market assessments across therapeutic areas. Familiarity with analytics and forecasting tools, such as advanced Excel modeling. Experience with Tableau, Power BI, or equivalent visualization platforms and portfolio management or valuation software (e.g., Planisware, Palantir) is a plus. Strong analytical, critical thinking, and problem-solving skills with the ability to synthesize complex data into actionable insights. Excellent written communication skills, including experience preparing executive-ready materials and analyses to support senior decision-making. Ability to work effectively in a cross-functional, fast-paced, and entrepreneurial environment, managing multiple priorities under tight deadlines. Collaborative team player with strong interpersonal skills and the ability to influence without authority. LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $148,000 - $203,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future. #LI-TD1

THE ROLE The Associate Director of Portfolio Business Analytics is a key contributor of Product and Partnering organization, a Flagship Pioneering initiative focused on conceiving and developing transformative treatments for patients. We build a portfolio of novel therapeutics by harnessing Flagship's scientific platforms and applying them to serious diseases beyond their current focus areas. Through this approach, we aim to bring the benefits of Flagship's innovation to more patients, faster. This role sits at the intersection of science, strategy, and finance-supporting portfolio decision-making through rigorous analytics, financial modeling, and market evaluation. The successful candidate will combine deep biopharma industry knowledge with advanced financial modeling skills, particularly in valuation and forecasting of pharmaceutical products across therapeutic areas and development stages. The individual will collaborate across R&D, business development, finance, and commercial strategy teams to generate data-driven insights that inform portfolio and investment decisions. KEY RESPONSIBILITIES Financial Modeling & Valuation * Develop robust, detailed financial models for Flagship's therapeutic programs and platforms, including revenue forecasts, valuation analyses (DCF, NPV, rNPV), and scenario planning. * Translate scientific, clinical, and operational assumptions into quantitative business models. * Support capital allocation analyses and portfolio prioritization through rigorous sensitivity and risk-adjusted analyses. * Maintain and improve financial models and forecasting frameworks as portfolio complexity increases. Market and Competitive Analytics * Conduct comprehensive market landscape analyses using both secondary sources and primary research (e.g., KOL interviews, surveys) to assess unmet needs, competitive dynamics, and market potential. * Monitor key trends in relevant therapeutic areas and biopharma markets to inform portfolio strategy. * Understand competitive positioning of ongoing and planned Pioneering Medicines programs. * Summarize market and competitor insights into clear, concise reports for leadership review. Portfolio Strategy & Governance Support * Build and maintain portfolio analytics tools and frameworks to support resource planning, portfolio valuation, and scenario modeling. * Prepare high-quality materials and analyses for internal governance and investment committee reviews, including portfolio summaries, risk assessments, and valuation comparisons. * Ensure consistent use of financial and operational metrics across programs and functions. * Benchmark portfolio and organizational performance against comparable biotech and pharma peers to identify key measures of success. Cross-Functional Collaboration * Partner closely with R&D, Competitive intelligence, Finance, Business Development, and Commercial Strategy teams to align scientific and business perspectives in portfolio analytics. * Collaborate with data and insights teams to integrate forecasting models with relevant clinical and operational data systems. * Serve as an analytical partner to program leads, helping teams understand value drivers, risks, and key decision points. * Collaborate with Finance on annual LRP process and output Leadership & Influence * Lead cross-functional analytical initiatives. * Proactively identify analytical or process improvements to enhance portfolio visibility and decision-making. * Champion data-driven and enterprise-level thinking across Pioneering Medicines teams. Operational Excellence * Build scalable systems and dashboards to enable efficient portfolio tracking and forecasting. * Drive standardization of assumptions, metrics, and templates across portfolio analyses. * Complete ad hoc requests and deliver outputs with minimal oversight in a timely manner. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Education (one of the following combinations): * Ph.D. in a life science discipline (e.g., Biology, Biomedicine, Chemistry, Pharmacology) with at least 3 years of relevant industry or consulting experience. * MBA with a strong quantitative or finance focus (e.g., healthcare management, finance, strategy) with at least 5 years of relevant experience. * Master's degree in life sciences, economics, finance, or a related field with at least 5 years of experience. * Bachelor's degree in life sciences, economics, finance, or a related field with at least 8 years of relevant experience. Experience: * Demonstrated expertise in financial modeling and valuation of pharmaceutical assets and portfolios, including revenue forecasting and risk-adjusted returns. * Experience in biopharma investment banking, Big 4 advisory, life science strategy consulting, or corporate/business development in biotech or pharma. * Proven ability to perform competitive analysis and market assessments across therapeutic areas. * Familiarity with analytics and forecasting tools, such as advanced Excel modeling. Experience with Tableau, Power BI, or equivalent visualization platforms and portfolio management or valuation software (e.g., Planisware, Palantir) is a plus. * Strong analytical, critical thinking, and problem-solving skills with the ability to synthesize complex data into actionable insights. * Excellent written communication skills, including experience preparing executive-ready materials and analyses to support senior decision-making. * Ability to work effectively in a cross-functional, fast-paced, and entrepreneurial environment, managing multiple priorities under tight deadlines. * Collaborative team player with strong interpersonal skills and the ability to influence without authority. LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $148,000 - $203,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future. #LI-TD1

The Executive Director, Business Planning will report to the COO, Product and Partnering and work directly with the President of Pioneering Medicines in a leadership capacity to deliver strategic and tactical execution against many different types of business needs that arise within Pioneering Medicines (PM) and across Flagship with partner functions and the portfolio of companies. Responsibilities Oversee day to day planning & administration of PM Ensure alignment across cross-functional teams on PM's objectives and monitor progress toward key milestones. Manage all Functional Governance including: Leadership Team, Extended Leadership Team, PM Oversight Board in partnership with the President, PM Act as a bridge between the President and other executive team members, facilitating effective communication and alignment. Act as a liaison between PM and support functions including HR, Finance and IT Manage cross functional efforts with these groups including the annual operating plan, PM SharePoint Hub, rollout of new IT systems, performance review process, knowledge management. Prepare executive-level communications, presentations, and reports for internal and external stakeholders. Own communication process and cadence for PBU including Sharepoint hub. Identify opportunities to improve operational efficiency and effectiveness across departments. Manage critical non-pipeline projects and initiatives, ensuring that they are executed on time and within budget, providing regular updates on project status. Foster a collaborative and supportive working environment that encourages cross-functional teamwork. Qualifications: Education: Bachelor's degree in Business Administration, Life Sciences, Biotechnology, or related fields. Advanced degree (MBA or equivalent) is preferred. At least 10 years of progressive experience in leadership roles within the biotech or life sciences industry. A proven ability to think strategically and drive initiatives that align with the company's long-term goals. Strong project management skills with experience in leading complex projects from conception to completion. Excellent written and verbal communication skills, with the ability to convey complex ideas clearly and concisely. Strong analytical and problem-solving skills with a data-driven approach to decision-making. Ability to lead cross-functional teams, inspire others, collaborate and influence stakeholders at all levels. A flexible and adaptive approach to navigate in a dynamic and fast-paced environment. Ability to work in a hybrid environment, being in the office 3 or more days per week and working ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** ABOUT PIONEERING MEDICINES Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $260,000 - $300,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future. #LI-TD1

The Executive Director, Business Planning will report to the COO, Product and Partnering and work directly with the President of Pioneering Medicines in a leadership capacity to deliver strategic and tactical execution against many different types of business needs that arise within Pioneering Medicines (PM) and across Flagship with partner functions and the portfolio of companies. Responsibilities * Oversee day to day planning & administration of PM * Ensure alignment across cross-functional teams on PM's objectives and monitor progress toward key milestones. * Manage all Functional Governance including: Leadership Team, Extended Leadership Team, PM Oversight Board in partnership with the President, PM * Act as a bridge between the President and other executive team members, facilitating effective communication and alignment. * Act as a liaison between PM and support functions including HR, Finance and IT * Manage cross functional efforts with these groups including the annual operating plan, PM SharePoint Hub, rollout of new IT systems, performance review process, knowledge management. * Prepare executive-level communications, presentations, and reports for internal and external stakeholders. * Own communication process and cadence for PBU including Sharepoint hub. * Identify opportunities to improve operational efficiency and effectiveness across departments. * Manage critical non-pipeline projects and initiatives, ensuring that they are executed on time and within budget, providing regular updates on project status. * Foster a collaborative and supportive working environment that encourages cross-functional teamwork. Qualifications: * Education: Bachelor's degree in Business Administration, Life Sciences, Biotechnology, or related fields. Advanced degree (MBA or equivalent) is preferred. * At least 10 years of progressive experience in leadership roles within the biotech or life sciences industry. * A proven ability to think strategically and drive initiatives that align with the company's long-term goals. * Strong project management skills with experience in leading complex projects from conception to completion. * Excellent written and verbal communication skills, with the ability to convey complex ideas clearly and concisely. * Strong analytical and problem-solving skills with a data-driven approach to decision-making. * Ability to lead cross-functional teams, inspire others, collaborate and influence stakeholders at all levels. * A flexible and adaptive approach to navigate in a dynamic and fast-paced environment. * Ability to work in a hybrid environment, being in the office 3 or more days per week and working ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** ABOUT PIONEERING MEDICINES Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production. At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $260,000 - $300,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future. #LI-TD1

What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner? Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines' approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. About Flagship Pioneering: Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. Position Summary: The Development Lead (Director or Senior Director level) plays a pivotal role on Pioneering Medicines (PM) project teams by driving the successful transition of programs from research into early clinical development. Reporting to the SVP of Project Leadership and Development (or a senior Development Project Leader), this role contributes to shaping clinical strategies that span from candidate discovery to human proof-of-concept (hPOC). As a core member of cross-functional teams, the Development Lead is responsible for crafting and integrating clinical development plans in alignment with research, translational, nonclinical, regulatory, and strategic priorities. This individual will also support program operations, resource planning, and interactions with internal governance and external partners. The role is ideal for an individual passionate about translating cutting-edge science into innovative medicines through rigorous, thoughtful, and collaborative development planning. Clinical and Strategic Development Lead the design of early clinical development plans (through hPOC) for PM programs, in alignment with the Target Product Profile (TPP). Collaborate closely with the SVP, Project Leaders, Research, Strategy, and external advisors/KOLs to define and refine clinical hypotheses and development strategies. Integrate clinical plans with translational, nonclinical, and regulatory development strategies to enable seamless progression from exploratory studies to FIH trials. Partner with Research teams-including MOA leads, Pharmacology, Translational Sciences, and Nonclinical Development-to align research outputs with clinical objectives. Work with the Strategy Group to ensure clinical plans support the TPP and the overall program value proposition. Incorporate regulatory input, operational feasibility, and real-world data to ensure robust and executable development strategies. Collaborate with Project Management to develop integrated timelines, resource forecasts, and budget assumptions for incorporation into NewCo planning. Support the preparation and delivery of key materials for internal governance forums and Joint Steering Committees (JSCs) with external partners. Identify and address development risks and bottlenecks proactively; drive resolution across functional interfaces. Promote a culture of scientific rigor, accountability, agility, and open collaboration within project teams. Enhance cross-functional integration by facilitating communication, alignment, and shared ownership of development goals. Qualifications: MD or MD with PhD with a robust scientific background 3-4 years of post-graduate/residency experience in industry or academic clinical research. Medical residency and/or subspecialty fellowship training preferred. Strong understanding of early clinical development and translational medicine, mechanisms of disease, and patient care paradigms in relevant therapeutic areas (immunology and/or metabolic diseases preferred) Demonstrated excellence in scientific rigor, operational decision making, risk mitigation, and innovation. Proven leadership and effective communication skills, with the ability to collaborate and convey strategic implications to diverse stakeholders. Excellent oral, written, and presentation skills for engaging stakeholders and fostering teamwork. Strong strategic thinking and critical thinking skills for identifying and addressing bottlenecks while optimizing cross-functional processes. Proactive and adaptable in demanding environments, with an operational mindset to improve efficiency and achieve strategic goals. About Flagship Pioneering: Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $195,000 - $290,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Position Overview: Flagship Pioneering is seeking a highly skilled and strategic compensation leader to oversee the design, management, and execution of non-executive compensation programs across our ecosystem. This role sits within the Total Rewards team and is responsible for Flagship's internal operations as well as its Series A and B Portfolio Companies globally. The ideal candidate brings deep expertise in broad-based compensation and market practices, combined with strong cross-functional leadership and executive presence. This is a pivotal leadership role with exposure to all facets of Total Rewards, including executive compensation, equity programs, and global compensation design. While the current focus is broad-based compensation, the right candidate will demonstrate the potential to grow into broader leadership within the Total Rewards function over time. Key Responsibilities: Compensation Program Leadership: Design, implement, and continuously refine broad-based compensation programs across a global footprint, including geographic differentials, salary structures, job leveling, and bonus frameworks. Lead annual compensation review cycles (merit, bonus, promotion) in close partnership with HR Business Partners, Finance, and Talent Acquisition. Collaborate with recruiting teams to craft competitive, market-aligned offers while maintaining internal equity. Conduct ongoing market benchmarking and compensation analysis, leveraging tools such as Radford and Pave. Maintain and evolve our pay transparency and pay equity frameworks across the organization. Strategic Collaboration & Stakeholder Management: Partner with executive compensation, equity, and benefits leads to ensure cohesive Total Rewards strategy. Serve as a thought partner to HRBPs and senior business leaders, providing guidance on compensation practices, offer structures, and policy interpretation. Prepare and deliver insights, reports, and recommendations to senior leadership. Global Compensation & Compliance: Maintain deep awareness of compensation regulations across key geographies Develop and maintain localization frameworks to ensure regional competitiveness and compliance. Advise on global mobility compensation matters and cross-border assignments. Team and Operational Excellence Manage compensation tools, systems, and workflows to ensure accurate, efficient program delivery. Support compensation-related aspects of M&A and new company creation initiatives. Qualifications: Bachelor's degree in Human Resources, Finance, Business Administration, or a related field; advanced degree and/or relevant certifications (e.g., CCP) a plus. 10+ years of progressive compensation experience, with specific expertise in broad-based compensation within high-growth or startup environments. Experience supporting global workforces and navigating complex, matrixed environments High executive presence with ability to influence senior stakeholders and deliver recommendations with clarity and confidence. Strong analytical skills with proficiency in Excel, market pricing tools, and HRIS platforms Background in biotech, tech, or high-growth venture-backed companies preferred PREFERRED QUALIFICATIONS Exposure to executive and equity compensation programs, even if not the primary area of responsibility Understanding of Total Rewards integration, including benefits, mobility, and people analytics Why Join Flagship Pioneering? This is a rare opportunity to play a critical role in shaping groundbreaking collaborations that drive scientific innovation. As Senior Counsel, Legal, you will operate at the intersection of business, law, and cutting-edge biotechnology, helping to build and support transformational partnerships that advance human health. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-NM1 The salary range for this role is $172,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

THE ROLE The Director/Senior Director, Digital Business Partnership - PBUs & FLs serves as the strategic digital interface between assigned Pioneering Business Units (PBUs) and Flagship Labs companies (FLs) and the broader Digital & IT organization. This role supports companies from their ProtoCo launch through to NewCo scaling and Operational GrowthCo transitions. Operating within Flagship's Business Partnership model, the Director is responsible for aligning digital strategy to business maturity, overseeing digital intake and prioritization, and coordinating execution readiness across matrixed IT delivery functions. This role ensures that each company's digital foundation is appropriately established and evolved in a way that enables scientific, operational, and partnership success. KEY RESPONSIBILITIES Strategic Engagement & Lifecycle Support Serve as the primary digital partner to assigned PBUs and FLs, providing continuous support from ProtoCo launch through GrowthCo transition. Support business leaders in translating scientific and operational strategies into aligned digital priorities. Sponsor the digital roadmap for each assigned company and represent digital priorities in Flagship governance forums. Ensure platform and infrastructure needs are met to support milestones such as funding events, BD engagement, etc... Support the adoption and application of Digital Launch and Operational Growth Transition (OGT) playbooks in collaboration with IT delivery functions and the Office of the CIO. Intake & Prioritization Lead intake and validation of digital requests across assigned companies; ensure alignment with enterprise platform strategy and standards. Collaborate with PMs, analysts, and delivery leaders to ensure scoping is supported by context, value, and timing. Sponsor business case development and ensure each initiative is prioritized through related governance forums. Track intake and roadmap status across companies using shared tools in collaboration with the Office of the CIO. Guide digital investment discussions with business leaders and coordinate Build budget inputs. Delivery Coordination & Governance Serve as a strategic liaison to IT delivery leads across Research Systems, Enterprise Applications, Infrastructure, and Cybersecurity. Ensure business needs are accurately reflected during project planning; hand off scoped initiatives to delivery teams for execution. Partner with IT delivery functions to support requirement gathering, testing coordination, and system validation readiness. Participate in project milestone and governance reviews as a business-aligned sponsor, but not as a delivery manager. Raise delivery risks, blockers, and coordination challenges to the Office of the CIO as needed to maintain portfolio alignment. PROFESSIONAL EXPERIENCE & QUALIFICATIONS 8-10+ years of experience in digital strategy, IT business partnership, or life sciences systems implementation. Experience supporting early-stage and growth-stage biotech companies, ideally within platform-based or portfolio models. Proven ability to work cross-functionally across science, operations, and IT to define and prioritize digital initiatives. Familiarity with cloud infrastructure, lab IT systems (e.g., Benchling, LIMS), collaboration platforms (e.g., M365), and cyber standards. Strong understanding of the challenges associated with scaling IT capabilities across maturing biotech organizations. Ability to manage multiple concurrent partnerships, prioritize across a portfolio, and influence without direct authority. ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-NM1 The salary range for this role is $172,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

Metaphore Biotechnologies, Inc. is a privately held biotechnology company building the next generation of biological therapeutics. Inspired by nature, our mission is to transform patient lives by unlocking the power of biological therapeutics with a new mimic-discovery platform. Role Summary Metaphore is seeking a Senior Director, CMC Development & External Manufacturing to lead end-to-end CMC strategy and execution for our biologics programs. This individual will have primary accountability for developing fit-for-stage drug substance and drug product processes with external manufacturing CDMOs. This leader will own the integrated CMC plan (strategy, timeline, budget, and risks), partner with key internal stakeholders to enable seamless transition into late stage CMC work and ensure CMC deliverables support regulatory submissions and clinical supply needs. Key Responsibilities Own end-to-end CMC strategy and execution, including governance, integrated plans (timeline/resources/interdependencies), scenario planning, supply forecasting, and risk management to deliver program and company milestones. Lead external CDMO strategy and oversight for drug substance and drug product (scope setting, operating cadence, deliverables/action tracking, issue escalation/resolution), ensuring execution success. Provide technical leadership across upstream/downstream, analytical, formulation, fill/finish, and stability, guiding fit-for-stage development decisions (e.g., scale-up strategy, formulation/container strategy, stability approach) and tech transfer readiness. Ensure phase-appropriate GMP readiness and campaign execution at the CDMO, including deviation/change/CAPA alignment with Quality and ensuring testing and disposition timelines support clinical needs. Drive CMC regulatory deliverables (CMC sections of submissions/amendments) and executive-level communication of status, decisions, risks, and mitigation plans; build/lead high-performing internal and matrixed teams. Required Qualifications Advanced degree (PhD preferred; MS with significant experience considered) in Chemical Engineering, Biochemistry, Pharmaceutical Sciences, or related discipline. 15+ years of biologics CMC experience spanning development through GMP manufacturing and external manufacturing oversight (drug substance and/or drug product). Proven ability to define CMC strategy and translate it into cross-functional deliverables, integrated plans, timelines, and budgets, with strong program leadership and operating rigor. Demonstrated success managing external collaborations/CDMOs to deliver CMC development and manufacturing outcomes in fast-paced, matrixed environments. Strong technical breadth in at least one major CMC area (and ability to lead across all), including upstream/downstream, analytics, and/or fill/finish/drug product with stability/tech transfer exposure. Deep working knowledge of cGMP/GxP and quality systems, with clear, concise communication and stakeholder influence skills. Desired Skills Define and execute strategic vision to advance scientific innovation, translating emerging insights into high-impact initiatives, roadmaps, and measurable outcomes. Act decisively and own end-to-end accountability, making timely, data-informed decisions, taking responsibility for results, and delivering against commitments in dynamic environments. Build change-agile, high-performing teams and networks, growing others through coaching and development, modeling strong self-awareness, and cultivating relationships with external thought leaders to accelerate learning and partnerships. About Flagship Pioneering Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $213,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Metaphore Biotechnologies, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Metaphore Biotechnologies, Inc.'s good faith estimate as of the date of publication and may be modified in the future.

Introduction Flagship Pioneering is a company that creates companies, building ground-breaking platforms that change the world. We are a brave and bold organization of creative-thinkers with insurgent mindsets and corporate-builders with incumbent expertise. What if... we could harness the power of data with AI to create breakthroughs and accelerate the creation of new technologies? This is the question that Flagship Pioneering seeks to explore with our latest AI-focused business unit. Our mission is to create, launch, and scale breakthrough ventures that transform how we live, work, and connect. We build companies from zero to one, with cutting-edge AI, exceptional user experience, and a strong vision to pioneer an AI-native future. Position summary As an Operating Principal, you will be the driving force behind a seed to Series A stage software/tech venture, responsible for validating core hypotheses, shaping early product direction, and helping with initial growth. You'll operate as a de facto Head of Operations - combining strategic vision, executional rigor, and entrepreneurial hustle to turn an early concept into a scalable business. This is a hands-on, high-impact role suited for a builder - someone who thrives in ambiguity, loves iterating on products and go-to-market strategies, and has a deep understanding of what it takes to make early-stage companies succeed. Key Responsibilities * Venture building: own the operational and strategic roadmap of an early-stage venture from idea validation through initial launch and traction. * Product-market fit: identify and test hypotheses rapidly through customer discovery, MVP development, and iterative experimentation. * Cross-functional leadership: coordinate with research, engineering, and growth teams to build, optimize and iterate software and tech products. * GTM strategy: define the target market, business model, and acquisition strategy to create scalable, repeatable growth engines. * Talent and culture: recruit early team members and establish the operating culture, processes, and principles. Lead with inspiration and inclusion Qualifications * Experience: 5-10 years in startups, consulting, or venture building - ideally with experience taking software platforms/products from concept to market. * Entrepreneurial mindset: Proven ability to thrive in ambiguity, move fast, and execute with limited resources. * Product fluency: Strong understanding of user research, MVP development, and data-informed decision-making. * Technical literacy: Familiarity with AI technologies (e.g., LLMs, generative AI, or data-driven personalization) and their consumer applications. * Leadership: Exceptional communication and cross-functional leadership, proven track record of building teams. * Bias for action: A pragmatic problem-solver who can balance strategic vision with operational excellence. Why join us * Build from scratch: Be at the forefront of world-shaping innovations and launch entirely new AI-native companies from scratch. * Operate like a founder: Own key decisions, strategy, and execution without the distractions of initial fundraising and administration. * Share the upside: Participate in the equity and long-term success of the ventures you help bring to life. ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $265,000 - $330,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

Introduction Flagship Pioneering is a company that creates companies, building ground-breaking platforms that change the world. We are a brave and bold organization of creative-thinkers with insurgent mindsets and corporate-builders with incumbent expertise. What if... we could harness the power of data with AI to create breakthroughs and accelerate the creation of new technologies? This is the question that Flagship Pioneering seeks to explore with our latest AI-focused business unit. Our mission is to create, launch, and scale breakthrough ventures that transform how we live, work, and connect. We build companies from zero to one, with cutting-edge AI, exceptional user experience, and a strong vision to pioneer an AI-native future. Position summary As an Operating Principal, you will be the driving force behind a seed to Series A stage software/tech venture, responsible for validating core hypotheses, shaping early product direction, and helping with initial growth. You'll operate as a de facto Head of Operations - combining strategic vision, executional rigor, and entrepreneurial hustle to turn an early concept into a scalable business. This is a hands-on, high-impact role suited for a builder - someone who thrives in ambiguity, loves iterating on products and go-to-market strategies, and has a deep understanding of what it takes to make early-stage companies succeed. Key Responsibilities Venture building: own the operational and strategic roadmap of an early-stage venture from idea validation through initial launch and traction. Product-market fit: identify and test hypotheses rapidly through customer discovery, MVP development, and iterative experimentation. Cross-functional leadership: coordinate with research, engineering, and growth teams to build, optimize and iterate software and tech products. GTM strategy: define the target market, business model, and acquisition strategy to create scalable, repeatable growth engines. Talent and culture: recruit early team members and establish the operating culture, processes, and principles. Lead with inspiration and inclusion Qualifications Experience: 5-10 years in startups, consulting, or venture building - ideally with experience taking software platforms/products from concept to market. Entrepreneurial mindset: Proven ability to thrive in ambiguity, move fast, and execute with limited resources. Product fluency: Strong understanding of user research, MVP development, and data-informed decision-making. Technical literacy: Familiarity with AI technologies (e.g., LLMs, generative AI, or data-driven personalization) and their consumer applications. Leadership: Exceptional communication and cross-functional leadership, proven track record of building teams. Bias for action: A pragmatic problem-solver who can balance strategic vision with operational excellence. Why join us Build from scratch: Be at the forefront of world-shaping innovations and launch entirely new AI-native companies from scratch. Operate like a founder: Own key decisions, strategy, and execution without the distractions of initial fundraising and administration. Share the upside: Participate in the equity and long-term success of the ventures you help bring to life. ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $265,000 - $330,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

ABOUT PROFOUND ProFound Therapeutics is pioneering the discovery of the expanded human proteome to unlock a new universe of potential therapeutics. By integrating multi-omics, advanced computation, and translational biology, we aim to reveal and characterize thousands of previously uncharted proteins and systematically explore their role in health and disease. THE ROLE We are seeking an experienced Associate Director / Director of AI & Machine Learning to join our growing team. This individual will play a key leadership role in shaping and executing our AI/ML strategy while remaining actively involved in hands-on model development and implementation. Reporting directly to our CTO, the successful candidate will lead the design and deployment of advanced machine learning systems - including generative and transformer-based models (LLMs), graph neural networks, and causal inference methods - within a multi-agent causal AI framework. These efforts will directly support the discovery of disease-driving proteins and pathways, advancing ProFound's mission to accelerate therapeutic development. KEY RESPONSIBILITIES Provide technical leadership while remaining hands-on in developing, training, and deploying AI/ML models. Architect and implement scalable ML systems that integrate multi-modal data (genomics, transcriptomics, proteomics, imaging, digital pathology, perturbation data). Lead the development of graph-based, transformer-based, and generative models (including LLMs and multi-modal transformers for biological and imaging data) to capture biological relationships and simulate interventions. Drive the creation of a multi-agent causal AI framework that integrates causal graph learning, interventional simulation, and knowledge graph reasoning. Collaborate with data engineering teams to design robust pipelines that harmonize and prepare large-scale omics datasets for model training. Implement, evaluate, and optimize causal inference approaches (e.g., DAG learning, treatment-effect estimation, counterfactual modeling). Partner closely with experimental scientists to ensure model outputs are biologically interpretable and experimentally testable. Mentor and develop junior AI/ML team members, fostering technical excellence and cross-disciplinary collaboration. Stay current with emerging advances in AI/ML, causal modeling, and computational biology; proactively introduce new approaches that strengthen the platform. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Ph.D. or M.S. in Computer Science, Computational Biology, Biostatistics, Applied Mathematics, or related field, with 7+ years of relevant post-graduate or industry experience (biotech, pharma, or AI/ML research). Demonstrated expertise in transformer architectures, LLMs, graph neural networks, and generative modeling. Strong background in causal inference and probabilistic modeling, with practical experience applying DAG-based or counterfactual methods. Proficiency in Python and ML frameworks such as PyTorch, TensorFlow, JAX, or PyTorch Geometric. Experience working with multi-omics or high-dimensional biological data strongly preferred. Proven ability to balance strategic leadership with hands-on development and deployment of advanced ML models. Familiarity with knowledge graph technologies and graph databases is a plus. Experience with computational imaging or digital pathology data integration is a strong plus. Excellent communication skills, with the ability to convey complex technical insights to experimental biologists and drug discovery teams. VALUES AND BEHAVIORS We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidate. We recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-MB1 The salary range for this role is $212,000 - $319,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. ProFound Therapeutics, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on ProFound Therapeutics, Inc.'s good faith estimate as of the date of publication and may be modified in the future.

ABOUT PROFOUND ProFound Therapeutics is pioneering the discovery of the expanded human proteome to unlock a new universe of potential therapeutics. By integrating multi-omics, advanced computation, and translational biology, we aim to reveal and characterize thousands of previously uncharted proteins and systematically explore their role in health and disease. THE ROLE We are seeking an experienced Associate Director / Director of AI & Machine Learning to join our growing team. This individual will play a key leadership role in shaping and executing our AI/ML strategy while remaining actively involved in hands-on model development and implementation. Reporting directly to our CTO, the successful candidate will lead the design and deployment of advanced machine learning systems - including generative and transformer-based models (LLMs), graph neural networks, and causal inference methods - within a multi-agent causal AI framework. These efforts will directly support the discovery of disease-driving proteins and pathways, advancing ProFound's mission to accelerate therapeutic development. KEY RESPONSIBILITIES * Provide technical leadership while remaining hands-on in developing, training, and deploying AI/ML models. * Architect and implement scalable ML systems that integrate multi-modal data (genomics, transcriptomics, proteomics, imaging, digital pathology, perturbation data). * Lead the development of graph-based, transformer-based, and generative models (including LLMs and multi-modal transformers for biological and imaging data) to capture biological relationships and simulate interventions. * Drive the creation of a multi-agent causal AI framework that integrates causal graph learning, interventional simulation, and knowledge graph reasoning. * Collaborate with data engineering teams to design robust pipelines that harmonize and prepare large-scale omics datasets for model training. * Implement, evaluate, and optimize causal inference approaches (e.g., DAG learning, treatment-effect estimation, counterfactual modeling). * Partner closely with experimental scientists to ensure model outputs are biologically interpretable and experimentally testable. * Mentor and develop junior AI/ML team members, fostering technical excellence and cross-disciplinary collaboration. * Stay current with emerging advances in AI/ML, causal modeling, and computational biology; proactively introduce new approaches that strengthen the platform. PROFESSIONAL EXPERIENCE & QUALIFICATIONS * Ph.D. or M.S. in Computer Science, Computational Biology, Biostatistics, Applied Mathematics, or related field, with 7+ years of relevant post-graduate or industry experience (biotech, pharma, or AI/ML research). * Demonstrated expertise in transformer architectures, LLMs, graph neural networks, and generative modeling. * Strong background in causal inference and probabilistic modeling, with practical experience applying DAG-based or counterfactual methods. * Proficiency in Python and ML frameworks such as PyTorch, TensorFlow, JAX, or PyTorch Geometric. * Experience working with multi-omics or high-dimensional biological data strongly preferred. * Proven ability to balance strategic leadership with hands-on development and deployment of advanced ML models. * Familiarity with knowledge graph technologies and graph databases is a plus. * Experience with computational imaging or digital pathology data integration is a strong plus. * Excellent communication skills, with the ability to convey complex technical insights to experimental biologists and drug discovery teams. VALUES AND BEHAVIORS We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidate. We recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-MB1 The salary range for this role is $212,000 - $319,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. ProFound Therapeutics, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on ProFound Therapeutics, Inc.'s good faith estimate as of the date of publication and may be modified in the future.