Senior Scientist jobs at Flagship Pioneering - 27 jobs

ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence builds on Flagship Pioneering's legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio of AI-first companies. As part of Flagship's integrated model of science, entrepreneurship, and capital, it transforms breakthrough ideas into world-changing companies, elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond. THE ROLE Pioneering Intelligence is a strategic initiative of Flagship Pioneering committed to positioning Flagship at the forefront of global prosperity through the synthesis of human, machine, and nature's intelligence -- which we call Polyintelligence. Pioneering Intelligence is seeking a Principal Scientist - Computational Protein Design to serve as the technical lead on computational antibody design efforts pushing the forefront of AI-based antibody design approaches on high value targets. This position will be in collaboration with Pioneering Medicines, Flagship Pioneering's initiative building a world-class biopharmaceutical R&D capability harnessing the power of Flagship's scientific platforms. As Principal Scientist - Computational Protein Design, you will lead technical development in computational antibody design and developability optimization, playing a pivotal role in advancing our AI-based design methods to build new foundational workflows for end-to-end antibody design, and apply those workflows to advance new medicines in collaboration with Pioneering Medicines. The ideal candidate will combine strong scientific and computational know-how with proficiency in working within highly matrixed, cross-functional team environments. Join us to shape the future of cutting-edge antibody therapeutics across Flagship's portfolio of technology platforms. KEY RESPONSIBILITIES Design and optimize antibodies using AI-based and structure-based approaches for binding and functionality. Create and apply computational methods for assessing and optimizing developability (stability, solubility, manufacturability, immunogenicity, polyreactivity, polyspecificity). Improve AI models with experimentally generated data. Stay at the forefront of AI and computational tools in antibody engineering. Provide scientific leadership and mentor team members. PROFESSIONAL EXPERIENCE & QUALIFICATIONS PhD in Biochemistry, Structural Biology, Biophysics, Protein Engineering, Computational Biology, Computer Science, or related field with 5+ years of relevant industry experience. Proven experience in the end-to-end design and optimization of antibodies for binding, functionality, and developability. Strong track record in utilizing AI and computational methods for antibody engineering, including but not limited to AI-based co-folding models and design models, and related structure-based design tools. Experience analyzing and interpreting antibody developability data. Experience leading projects in antibody discovery or biologics development. Preferred Qualifications Expertise in a breadth of antibody modalities, including mAbs, bispecifics or multispecifics, antibody-drug conjugates (ADCs), and antibody fragments. Experience developing and training novel AI and machine learning models for protein engineering utilizing deep learning architectures. ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $179,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Intelligence currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Intelligence's good faith estimate as of the date of publication and may be modified in the future. #LI-MB1

Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of Synteins™, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional scientists who are passionate about driving therapeutic modality innovation in biotechnology. Abiologics was founded in Flagship Pioneering's venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines were conceived and created. Since Flagship's founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents. THE ROLE We are seeking an experienced and motivated Senior Scientist in Medicinal Chemistry specializing in miniprotein and peptide drugs. The successful candidate will lead projects in designing, synthesizing, and optimizing novel miniprotein therapeutics called Synteins™. This role offers a unique opportunity to bring a new drug modality from early-stage research through to clinical development. KEY RESPONSIBILITIES Independently plan, execute, interpret, and optimize Syntein structure-activity campaigns through direct, hands-on laboratory work. Implement modern peptide chemistry and conjugation methodologies to accelerate optimization of miniprotein drug development. Collaborate with cross-functional teams including computational chemistry, biology, and pharmacology to drive project success. Drive bench-side innovation, ensuring that ideas transition seamlessly from concept to reality Mentor and guide junior scientists, fostering a collaborative and dynamic laboratory environment. Contribute to patent applications and scientific publications, showcasing lab innovation. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Ph.D. in Medicinal Chemistry, Synthetic Organic Chemistry, Chemical Biology, or related field, with a minimum of 5 years of industry experience. Strong track record of laboratory-based innovation and problem-solving in drug discovery including optimization of affinity, selectivity, drug properties, and PK profile. Proven expertise in the hands-on peptide synthesis. Ability to lead and inspire a team of scientists in a dynamic research setting. Excellent communication skills for both technical and non-technical audiences. Able to work on-site and attend in-person meetings. ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-MB1 The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Abiologics, Inc currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Abiologics, Inc's good faith estimate as of the date of publication and may be modified in the future.

Mirai Bio, Inc is a Flagship backed, privately held biotechnology company on a mission to transform the current approach to information molecule therapeutics to unlock their full therapeutic potential. In recent years, we have begun to experience the power of information molecules in treating historically undruggable diseases and in designing therapies with unprecedented turnaround times. Mirai's platform integrates nanoparticle development with world-class informatics technologies and a novel pipeline of experimentation and discovery to drive a new generation of highly effective, therapeutically relevant information molecule therapies. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! Mirai was founded by Flagship Pioneering. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. The current Flagship ecosystem comprises 37 transformative companies, including: Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture, and Sana Biotechnology (NASDAQ: SANA). Position Summary: We are seeking a highly experienced and innovative Principal Scientist to lead analytical development activities focused on novel lipid nanoparticles (LNPs) and nucleic acid cargos (RNA/DNA) for therapeutics and vaccines. The successful candidate will play a critical role in method development, characterization, and control strategies for novel LNP compositions at different stages of development from platform research to IND+. The role requires deep expertise in analytical chemistry and physicochemical / biophysical analyses for nanoparticle and nucleic acid characterization. Key Responsibilities: Lead analytical method development and testing for characterization of LNP-based drug products and nucleic acid drug substances (incl. RNA, DNA). Oversee analytical team to provide broad testing support across R&D functions using platform methods including lipid and nucleic acid composition, integrity, purity, particle size, encapsulation, and more. On-site presence and active hands-on involvement in experimental work is expected Design and execute complex experiments for in-depth characterization using DLS, HPLC, LC-MS, SEC, FFF/SEC-MALS, CE, UV-Vis, NMR, Cryo-EM and other advanced techniques for nanoparticle characterization. Collaborate with Formulation, Process Development, and Translational teams to support batch testing, stability characterization, optimization, and troubleshooting. Contribute to establishing acceptable ranges for critical quality attributes (CQAs) and parameters (CPPs). Manage/establish methods at external labs / CROs to complement internal capability. Ensure lab instruments are in working condition, manage instrument vendors, and organize demonstrations of new equipment. Prepare and review documentation including certificates of analysis, method protocols, laboratory notebooks, and reports. Stay current with emerging analytical technologies and industry trends in LNP-based delivery systems, including targeted LNPs. Supervise and mentor junior scientists and foster a culture of scientific and operational excellence. Qualifications: Ph.D. in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or a related discipline with 8+ years of relevant industry experience; or M.S. with 10+ years. Demonstrated expertise with analytical methods for lipid nanoparticle characterization, including biochemical / biophysical methods. Experience with characterization of nucleic acid-based therapeutics (mRNA, si RNA, DNA). Experience with characterization of proteins, mAbs, antibody fragments, and peptides Hands-on experience with techniques including HPLC, DLS, NTA, CE, LC-MS/MS, UV-Vis spectroscopy, and single-particle characterization methods. Excellent problem-solving, communication, and leadership skills. Prior experience in a supervisory role Preferred Skills: Experience working with external labs and/or CDMOs in a matrixed development environment. Prior involvement in early stage development and IND filings, preferably for genetic medicines. Familiarity with stability studies, forced degradation, and comparability assessments. Familiarity with molecular biology and bioconjugation techniques Awareness of ICH guidelines, GMP, and regulatory expectations for analytical method validation and CMC submissions. ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $163,000 - $214,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Mirai Bio currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Mirai Bio's good faith estimate as of the date of publication and may be modified in the future.

What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner? Pioneering Medicines, a division of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines' approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. About Flagship Pioneering: Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. Position Summary: We are seeking a highly capable bioinformatics expert to join the Pioneering Medicines Translational Sciences Team. This person will lead the computational efforts on drug discovery programs, integrate, analyze and interpret omics data and effectively communicate results to impact target discovery, translational and patient stratification efforts across disease areas. This individual will collaborate with the translational research, biology, ADME/Tox and early development teams, in order to help execute on research program strategy. This role is well-suited for individuals who combine scientific depth with strong computational acumen and thrive in dynamic, cross-functional environments. Key Responsibilities: Lead Translational Bioinformatics projects in various areas, including but not limited to oncology/I&I, cardiovascular, renal, metabolic and pulmonary diseases. Coach other team members on strategic thinking and next level synthesis and communication skills. Propose, evaluate and champion state-of-the-art computational omics approaches to answer key biological questions. Mine genomics datasets to identify novel targets for small molecule and biological therapies. Apply machine learning and AI approaches to uncover novel insights, including dimensionality reduction, clustering, classification, predictive modeling, and network-based inference. Drive analyses or internalize expertise if needed, for a rich suite of data modalities: bulk and single cell RNAseq/genomics, spatial genomics, proteomics, and state-of-the-art modeling techniques, tailored to specific programs and disease areas. Work closely with the in-vivo, in-vitro and translational research teams to translate biological questions into analytical solutions, including influencing experimental design, analyzing data and visualizing results. Required Qualifications: Ph.D in Bioinformatics, Computational Biology, Biological Sciences, or related discipline and 4+ years of industry experience as a bioinformatics representative on drug discovery programs. Understanding of biology and/or translational research and ability to address biological questions using computational approaches; in-depth knowledge of cancer genomics, tumor immunology, immunology or other related areas. Succesful track record collaborating with cross-functional scientific teams. Experience with state-of-the-art methods for next generation sequencing data. Experience integrating genetic, genomic and pathway/network datasets with novel experimental data to derive biological understanding. Fluency in R, Python or any other broadly used programming languages and environments like Code Ocean, AWS, git. Demonstrated application of AI/ML to biological datasets, including algorithm development or use of libraries like scikit-learn, XGBoost, Pinnacle. Excellent problem-solving, teamwork and communication skills, with an ability to effectively interact with people in a dynamic matrix environment, both internally and externally. Preferred: Exposure to translational science, patient stratification, or biomarker discovery in preclinical or clinical contexts. Experience integrating heterogeneous omics data. Knowledge of experimental design and data QC best practices. Prior experience in biotech or pharma. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TD1 The salary range for this role is $148,000 - $203,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

FL108 Inc., is a privately held, early-stage biotechnology company focused on developing novel protein-based delivery modalities. FL108 is backed by Flagship Pioneering, bringing the vision and resources to guide FL108 from platform validation to real-world solutions that meaningfully improve patient care. Position Summary: We are seeking a passionate, creative, and self-driven (senior) scientist with expertise in computational protein design and state of the art AI/ML tooling for antibody and protein design to join our team. This candidate will pioneer the design of novel protein-based delivery modalities and collaborate with the experimental teams to test and iterate on computational designs. S/he will thrive in an entrepreneurial, fast-paced, and highly collaborative start-up environment, with the opportunity to work closely with Flagship Pioneering founders and become a leader in advancing FL108's scientific platform and patient-focused mission. Responsibilities: Drive the AI/ML computational protein design Engage with Pioneering Intelligence at Flagship to explore and implement novel ML models that benefit FL108 design principles Advance both antibody engineering and de novo antibody design pipelines Collaborate closely with the Fl108 experimental scientists to test and iterate on constructs Engineer novel functionalities into protein scaffolds, leveraging structural modeling, rational design, and/or directed evolution Be abreast of the computational protein design field to advise design and strategic directions for protein engineering, implementing the latest technologies where necessary Contribute to strategic direction of the computational team at FL108, helping shape our design platform at the forefront of scientific innovation Identify and lead external research relationships with academic and commercial partners Report results to scientific team and Flagship Pioneering management Key Qualifications: Ph.D. (with 2+ yrs of industry research experience ) in computational protein design, protein biochemistry, computational biophysics, computational biology, physics, or related field Expertise in computational protein modeling and design, structural biology, and biophysics is required Deep expertise with ML tools for computational protein design such as AlphaFold, RosettaFold, ESMFold, ProteinMPNN, RFDiffusion, Chroma, IgFold, DeepAb, Parapredis is required Experience with antibody and/or nanobody modeling and design is strongly preferred. Knowledge of critical wet-lab techniques used in protein engineering such as phage display, SPR, ITC, CD-spectroscopy is preferred Strategic thinker, able to shift seamlessly between rigorous scientific details and high-level context and implications Instinctive team player with excellent communication skills and great attention to detail About Flagship Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $115,000 - $258,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL108 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL108's good faith estimate as of the date of publication and may be modified in the future.

FL108 Inc., is a privately held, early-stage biotechnology company focused on developing novel protein-based delivery modalities. FL108 is backed by Flagship Pioneering, bringing the vision and resources to guide FL108 from platform validation to real-world solutions that meaningfully improve patient care. Position Summary: We are seeking a passionate, creative, and self-driven (senior) scientist with expertise in computational protein design and state of the art AI/ML tooling for antibody and protein design to join our team. This candidate will pioneer the design of novel protein-based delivery modalities and collaborate with the experimental teams to test and iterate on computational designs. S/he will thrive in an entrepreneurial, fast-paced, and highly collaborative start-up environment, with the opportunity to work closely with Flagship Pioneering founders and become a leader in advancing FL108's scientific platform and patient-focused mission. Responsibilities: * Drive the AI/ML computational protein design * Engage with Pioneering Intelligence at Flagship to explore and implement novel ML models that benefit FL108 design principles * Advance both antibody engineering and de novo antibody design pipelines * Collaborate closely with the Fl108 experimental scientists to test and iterate on constructs * Engineer novel functionalities into protein scaffolds, leveraging structural modeling, rational design, and/or directed evolution * Be abreast of the computational protein design field to advise design and strategic directions for protein engineering, implementing the latest technologies where necessary * Contribute to strategic direction of the computational team at FL108, helping shape our design platform at the forefront of scientific innovation * Identify and lead external research relationships with academic and commercial partners * Report results to scientific team and Flagship Pioneering management Key Qualifications: * Ph.D. (with 2+ yrs of industry research experience) in computational protein design, protein biochemistry, computational biophysics, computational biology, physics, or related field * Expertise in computational protein modeling and design, structural biology, and biophysics is required * Deep expertise with ML tools for computational protein design such as AlphaFold, RosettaFold, ESMFold, ProteinMPNN, RFDiffusion, Chroma, IgFold, DeepAb, Parapredis is required * Experience with antibody and/or nanobody modeling and design is strongly preferred. * Knowledge of critical wet-lab techniques used in protein engineering such as phage display, SPR, ITC, CD-spectroscopy is preferred * Strategic thinker, able to shift seamlessly between rigorous scientific details and high-level context and implications * Instinctive team player with excellent communication skills and great attention to detail About Flagship Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $115,000 - $258,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL108 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL108's good faith estimate as of the date of publication and may be modified in the future.

FL105 is a privately held, early-stage company pioneering the use of artificial intelligence to build a new AI-driven platform utilizing digital twins and simulation, with applications that span psychological modeling, behavior prediction and beyond. Our goal is to move past chatbot-era tools and toward multi-modal systems that can reason, simulate and adapt in open-ended ways. FL105 is backed by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and builds companies that invent breakthrough technologies to transform health care, agriculture, and sustainability. Flagship has created over 100 groundbreaking companies since 2000, including Moderna. THE ROLE FL105 seeking a talented Machine Learning Scientist. The successful candidate will develop and apply machine learning (ML) methods to create foundational psychological tools. This position is ideal for someone with broad expertise in machine learning, deep learning, and computational sciences who is looking to join a very dynamic and innovative environment and pioneer the next frontier of innovation, application, and human-computer interactions enabled by generative models. You will build technologies that enable others to maximize their potential. Working at FL105, you will be able to openly collaborate with Pioneering Intelligence, the AI/ML research arm of Flagship Pioneering. You will have the opportunity to work with world-class machine learning scientists and engineers who work on cutting-edge AI research in generative modeling and large language models. KEY RESPONSIBILITIES Design and implement research programs to understand and emulate human behavior, personality, and emotional patterns using the state-of-the-art ML techniques Collaborate with psychological experts and translate interdisciplinary insights into computational frameworks. Build scalable pipelines for data collection, labeling, training, and deployment of LLM-based systems. Contribute to the development of novel methods for controlling large language models. Support the integration of ML systems into real-world applications with measurable outcomes. Stay current with advances in AI/ML and bring forward ideas that drive scientific and product innovation. Communicate findings to a multi-disciplinary audience. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Advanced degree (PhD or MS) in Computer Science, Machine Learning, Applied Mathematics, or a related field. Strong foundation in machine learning, deep learning, and natural language processing (NLP). Experience working with open-source large language models (e.g., LLaMA, Gemma, Qwen) and modern ML frameworks (e.g., PyTorch, JAX, TensorFlow). Experience with multimodal deep learning systems is a bonus. Demonstrated ability to design, run, and interpret ML experiments in research or applied settings. Proficiency in Python and tools for ML development, data processing, and evaluation. Comfort working in ambiguous, fast-moving environments with evolving goals and limited structure. Excellent communication and presentation skills Must be able to think independently and work collaboratively Motivated and team oriented, with an ability to thrive in a multidisciplinary environment ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-MB1 The salary range for this role is $136,000 - $313,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL105 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL105's good faith estimate as of the date of publication and may be modified in the future.

ProFound Therapeutics is seeking a pioneering Senior Scientist/Principal Scientist, Biostatistics & Computational Biology to advance the ProFoundry™ Platform through rigorous statistical modeling, inference, and translational analytics. This role is ideal for a candidate with deep expertise in biostatistics, theoretical statistics, and quantitative data analysis, who is passionate about applying statistical principles to complex biological data relevant to cardiometabolic or neurodegenerative disorders to drive therapeutic discovery. The ProFoundry Atlas-a proprietary resource of genetic, transcriptomic, proteomic, and imaging data-offers a unique opportunity to uncover novel biological insights and prioritize targets for drug development. The successful candidate will play a central role in developing statistical frameworks and analytical pipelines that support preclinical research, target validation, and portfolio decision-making. Company Summary ProFound Therapeutics is a privately held, early-stage biotechnology company founded by Flagship Pioneering, the creators of over 75 transformative companies including Moderna Therapeutics (NASDAQ: MRNA), Seres Therapeutics (MCRB), and Indigo Agriculture. ProFound is built on a foundation of scientific innovation and entrepreneurial spirit, with a mission to redefine the boundaries of human therapeutics. Key Responsibilities Design and implement statistical models for analyzing high-dimensional biological data, including genomics, transcriptomics, proteomics, and imaging relevant to cardiometabolic or neurodegenerative disorders Apply principles of theoretical and applied statistics to develop novel inference methods tailored to biological questions Lead the development of robust, reproducible pipelines for hypothesis testing, causal inference, and predictive modeling across multi-omics datasets Collaborate with interdisciplinary teams to translate statistical findings into biological insights and therapeutic hypotheses Develop simulation frameworks and statistical benchmarking tools to evaluate model performance and data quality Apply advanced statistical modeling to support target discovery, prioritization, and validation, integrating multi-omics and functional data Design and analyze preclinical experiments, including dose-response studies, biomarker discovery, and mechanistic investigations Use Bayesian and frequentist frameworks to quantify uncertainty and support decision-making in early-stage drug development Build simulation models to assess study designs, optimize resource allocation, and forecast outcomes in preclinical pipelines Contribute to portfolio-level analytics, helping prioritize targets based on statistical evidence, biological plausibility, and translational potential Support statistical planning for in vitro and in vivo studies, including power calculations, randomization schemes, and reproducibility assessments Develop scoring systems and prioritization frameworks for ranking therapeutic targets using multi-dimensional data inputs Ensure statistical rigor in the interpretation of experimental results, guiding go/no-go decisions and milestone reviews Minimum Qualifications PhD in Biostatistics, Statistics, Applied Mathematics, or a related quantitative field with 3+ years of postdoctoral or industry experience; or MS with 7+ years of relevant experience Strong foundation in statistical theory, including probability, inference, regression, and multivariate analysis Experience applying statistical methods to biological or biomedical datasets, including genomics, transcriptomics, or clinical data relevant to cardiometabolic/neurodegenerative disorders Proficiency in statistical programming languages (e.g., R, Python) and familiarity with statistical computing environments Demonstrated ability to develop and validate statistical models and algorithms for complex, high-dimensional data Commitment to reproducible research and collaborative problem-solving Excellent communication skills, with the ability to explain statistical concepts to non-statistical audiences Preferred Qualifications Expertise in Bayesian statistics, hierarchical modeling, and probabilistic graphical models Experience with longitudinal data analysis, survival analysis, and time-to-event modeling in clinical or biomedical contexts relevant to cardiometabolic/neurodegenerative disorders Familiarity with causal inference frameworks, such as propensity score methods, instrumental variables, or structural equation modeling Knowledge of experimental design, including randomized trials, adaptive designs, and observational study methodologies Experience with dimension reduction techniques (e.g., factor analysis, t-SNE, UMAP) and high-dimensional inference Exposure to functional data analysis, spatial statistics, or statistical methods for imaging data Familiarity with meta-analysis, statistical harmonization, and federated data analysis across cohorts Experience with statistical consulting or collaboration in multidisciplinary teams, especially in biomedical or pharmaceutical settings Knowledge of regulatory standards and statistical considerations in drug development (e.g., FDA guidelines, ICH E9/E10) Experience with statistical software development, package creation in R/Python, or contributions to open-source statistical tools Familiarity with cloud-based statistical workflows and scalable computing (e.g., parallel processing, distributed computing frameworks) Experience in preclinical biostatistics, including statistical design and analysis of in vitro and in vivo studies Familiarity with dose-response modeling, pharmacokinetic/pharmacodynamic (PK/PD) modeling, and biomarker evaluation Knowledge of target validation pipelines, including CRISPR screens, RNAi, and functional genomics Exposure to portfolio analytics and decision-support tools used in early drug discovery Understanding of statistical considerations in translational research, including bridging preclinical and clinical data Experience with model-based prioritization frameworks, such as multi-criteria decision analysis (MCDA) or machine learning-based scoring systems Ability to communicate statistical findings in the context of biological relevance and therapeutic strategy ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-MB1 The salary range for this role is $146,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. ProFound Therapeutics, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on ProFound Therapeutics, Inc.'s good faith estimate as of the date of publication and may be modified in the future.

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? Expedition Medicines is a privately held, early-stage biotechnology company pioneering the emerging field of Protein Editing. At Expedition Medicines we create small molecules that edit protein structure and function to unlock presently undruggable targets and a broad array of therapeutic modalities. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to enable generative design. Expedition Medicines is backed by Flagship Pioneering, bringing their courage, vision, and resources to guide Expedition Medicines from platform validation to patient impact. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! About the role: We are seeking a Senior / Principal Scientist level medicinal chemist to join our chemistry team at Expedition Medicines. This position will be responsible for the medicinal chemistry strategy and delivery on one or more projects. A candidate with experience collaborating with a machine learning team to deliver against project goals is a plus. Candidate responsibilities: Design and deliver medicinal chemistry strategy on project(s). Optimize small molecules through analysis of biochemical, biological, and ADME assay data. Manage chemistry CROs for timely delivery of synthetic efforts. Collaborate with cross-functional teams for project needs in high-paced data-driven environment. Collaborate with machine learning team for delivery against medicinal chemistry strategy. Contribute to patent applications and scientific publications. Qualifications: PhD in synthetic organic or medicinal chemistry with at least 5 years' drug discovery experience in pharmaceutical industry or BS/BA in chemistry with at least 10 years' experience in pharmaceutical industry. Strong modern synthetic background preferred with knowledge of state-of-the-art organic chemistry methodologies. Experience managing external chemistry CROs. Experience collaborating with machine learning teams preferred. Experience with both traditional small molecules and beyond-rule-of-5 therapeutic modalities is a plus. Strong communication and interpersonal skills. LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-MB1 The salary range for this role is $126,000 - $214,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Expedition Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Expedition Medicines's good faith estimate as of the date of publication and may be modified in the future.

ABOUT PIONEERING INTELLIGENCE Pioneering Intelligence builds on Flagship Pioneering's legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio of AI-first companies. As part of Flagship's integrated model of science, entrepreneurship, and capital, it transforms breakthrough ideas into world-changing companies, elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond. THE ROLE We are seeking a Principal Scientist (Embedded ML/Computational) to lead multiple AI/ML or computational projects across early stage ventures, as a part of Flagship's company origination process. You will define and deliver pragmatic AI strategies, oversee method and platform development (e.g., systems design, drug design, molecular modeling, systems biology, protein design, LLM/agentic workflows), and ensure rigor in model development, benchmarking, scaling, and reporting. You will manage cross functional contributors as applicable, influence company direction, and represent PI to venture teams and external partners. The ideal candidate is a self-directed serial deep diver - someone who can move from protein design one week to mass spec or docking pipelines the next and then spin up LLM based agents that automate scientific workflows. KEY RESPONSIBILITIES Program Leadership: Lead development, implementation, control, and reporting of several AI/ML or computational projects within assigned ventures in line with broader strategic plans of PI and Flagship, budgets, and timelines. Technical Ownership: Take a specialized technical role on project teams to oversee method development, pipeline development, and LLM based agent/workflow design; drive benchmarking, scaling, and implementation into production grade systems. Best Practices: promote operational excellence in AI projects by educating cross-functional collaborators. Team Leadership: Manage and/or coordinate internal and external scientists/engineers and crossfunctional project teams as applicable; mentor early hires; support recruiting and interview. Planning & Resourcing: Contribute to project planning, including budgets, resources, and timelines; surface risks and tradeoffs early with clear options. Landscape & Strategy: Independently scout emerging literature and the AI/ML landscape; synthesize concepts to propose new development strategies and identify opportunities for PI and venture portfolios. Representation & Community: Represent PI to portfolio companies and external partners; act as a recognized subject matter expert; actively participate in scientific conferences and meetings. Communication & Influence: Influence the course of projects and technical approaches; adapt and present complex findings to diverse audiences to support meaningful interpretation and action. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Master's, or PhD in a relevant field (e.g., machine learning, mathematics, statistics, computational sciences) with 5+ years' experience scientific/engineering/computational in academic, pharmaceutical, or biotechnology settings; industry AI/ML experience preferred. Experience driving results directly or indirectly through teams of engineers/scientists in dynamic, fastpaced, entrepreneurial, and technical environments. Clear evidence of sustained independent thought and creativity driving high impact, cross disciplinary AI/ML projects. Successful track record of leadership and contribution to decision making on progression of AI/ML models within projects or programs. Depth across multiple core tools and concepts, including Python; modern ML frameworks (PyTorch or JAX/TensorFlow); version control; databases; deep learning architectures; and relevant informatics software. Consistent record of outstanding performance reflected in publications, patents, or high impact internal reports where applicable Preferred Qualifications Breadth across domains such as protein modeling/design, proteomics/mass spec, cheminformatics/docking/ADMET, biophysics/MD, and LLM/agentic automation. MLOps expertise: data contracts and lineage (e.g., DVC/LakeFS), experiment tracking (MLflow/W&B), secure AWS infrastructure (S3, Batch/ECS/EKS, SageMaker), Docker, IaC (Terraform/CDK), and CI/CD (GitHub Actions). Generative modeling (diffusion/flow/VAEs) for sequences, graphs, or 3D structures; docking rescoring (e.g., gnina, DiffDock) and pose quality metrics. Workflow orchestration (Airflow/Prefect/Argo), data warehouses (Redshift/Snowflake), vector search (FAISS/pgvector), and lightweight internal tools (FastAPI, Streamlit/Gradio). Experience mentoring early hires, acting as interim Head of ML, and contributing to hiring plans and interview processes at startups. WHY PIONEERING INTELLIGENCE Operate at the frontier: Build and deploy AI/ML that directly powers discovery and decision making across multiple new ventures. Own the full stack: From scoping and data contracts to models, MLOps, and internal UIs-ship endtoend systems that scientists rely on daily. Compound impact: Convert one off wins into shared libraries and templates adopted across the PI portfolio. Work with founders: Partner closely with venture leadership and PI platform engineers; influence strategy through hands on delivery. Grow fast: Stretch across domains, take on situational leadership, present at conferences, and help shape first ML teams. ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-MB1 The salary range for this role is $208,000 - $286,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Intelligence currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Intelligence's good faith estimate as of the date of publication and may be modified in the future.

Our start-up is building a novel chemical discovery platform to reshape how we develop formulations at the molecular level. By combining artificial intelligence with a cutting-edge laboratory discovery pipeline, our interdisciplinary team will chart an unexplored chemical landscape, enabling breakthroughs in drug delivery, agrichemical formulation, and safe, high-performance industrial chemicals. Our company is backed by Flagship Pioneering, a biotechnology origination company that has founded and developed over 115 scientific ventures over the past 25 years. Flagship Pioneering is dedicated to the development of an ecosystem of first-in-category life sciences companies, resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. THE ROLE We are seeking an experienced formulations chemist to lead the design, strategy, and implementation of a high-throughput chemical formulation and testing pipeline. This position will focus on building a rapid and evolving system for manufacturing chemical mixtures and measuring the physiochemical properties of these mixtures at various temperatures and levels of hydration. This position will also coordinate heavily with a Machine Learning Lead to integrate the bench top pipeline output with the training and output of a predictive model for formulation chemistry. The ideal candidate will have a strong background in organic chemistry, high-throughput chemical screening, spectroscopy, calorimetry, and other advanced techniques for the physical characterization of chemicals. KEY RESPONSIBILITIES * Manufacturing formulations * Design and implement a scalable high-throughput workflow for generating diverse chemical mixtures. * Rigorously catalog known formulations for comparison to newly developed and untested formulations. * Establish automated liquid handling, dosing, and mixing protocols to ensure reproducibility and throughput. * Develop standard operating procedures (SOPs) for safe handling, storage, and disposal of raw materials and formulations. * Collaborate with upstream ML lead on formulation design workflows that maximize our canvassing of chemical property space and support the generation of high-quality, broad-coverage training data. * Characterizing formulation properties * Assess viscosity, solubility, and other physiochemical features under different hydration and temperature conditions. * Apply spectroscopy (UV-Vis, IR, fluorescence) to quantify molecular interactions and stability. * Use calorimetry and thermal gravimetric analysis to measure thermodynamic and thermal stability profiles of formulations. * Develop and validate assays to track long-term stability and degradation of formulations. * Screening formulation-cargo interactions * Design assays to evaluate compatibility of formulations with diverse small molecules, peptides, proteins, and nucleic acids. * Measure cargo protection and stability (e.g., aggregation, precipitation, degradation) under varied conditions. * Integrate biophysical characterization methods (DLS, CD, IR, LCMS) to assess cargo-formulation interactions. PROFESSIONAL EXPERIENCE & QUALIFICATIONS * Ph.D. in Organic Chemistry, Physical Chemistry, Chemical Engineering, Materials Science, or a related field + 5 years of experience (including 2 years of industry at minimum). Education may count towards years of experience. * Extensive hands-on experience with formulation chemistry, high-throughput chemical screening, or analytical method development. * Demonstrated expertise in chemical characterization techniques such as spectroscopy (UV-Vis, IR, NMR, fluorescence), calorimetry (DSC, ITC), and rheology. * Proven ability to characterize physicochemical properties of complex mixtures under varying environmental conditions. * Strong background in designing and executing high-throughput or automated experimental workflows. * Committed team player with the ability to communicate and work collaboratively with ML scientists, lab scientists and operational team members. * Prior leadership or team management experience preferred. * Experience integrating benchtop experimental data into machine learning pipelines or predictive modeling workflows preferred. * Strong understanding of thermodynamics, kinetics, and intermolecular interactions in multicomponent systems preferred. * Familiarity with high-throughput robotics, automation platforms, or liquid handling systems for screening of solvents and liquids preferred. * Knowledge of data analysis pipelines, including scripting skills (e.g., Python, R, MATLAB) for handling large experimental datasets preferred. * Exposure to generative AI models for chemical discovery preferred. * Experience working with biomolecules and protein chemistry preferred. * Familiarity with principles of physical chemistry preferred. * Experience in chemistry screening for personal care, nutrition, or aqueous coatings and adhesives preferred. LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TL1 The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL118 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL118's good faith estimate as of the date of publication and may be modified in the future.

Our start-up is building a novel chemical discovery platform to reshape how we develop formulations at the molecular level. By combining artificial intelligence with a cutting-edge laboratory discovery pipeline, our interdisciplinary team will chart an unexplored chemical landscape, enabling breakthroughs in drug delivery, agrichemical formulation, and safe, high-performance industrial chemicals. Our company is backed by Flagship Pioneering, a biotechnology origination company that has founded and developed over 115 scientific ventures over the past 25 years. Flagship Pioneering is dedicated to the development of an ecosystem of first-in-category life sciences companies, resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. THE ROLE We are seeking an experienced formulations chemist to lead the design, strategy, and implementation of a high-throughput chemical formulation and testing pipeline. This position will focus on building a rapid and evolving system for manufacturing chemical mixtures and measuring the physiochemical properties of these mixtures at various temperatures and levels of hydration. This position will also coordinate heavily with a Machine Learning Lead to integrate the bench top pipeline output with the training and output of a predictive model for formulation chemistry. The ideal candidate will have a strong background in organic chemistry, high-throughput chemical screening, spectroscopy, calorimetry, and other advanced techniques for the physical characterization of chemicals. KEY RESPONSIBILITIES Manufacturing formulations Design and implement a scalable high-throughput workflow for generating diverse chemical mixtures. Rigorously catalog known formulations for comparison to newly developed and untested formulations. Establish automated liquid handling, dosing, and mixing protocols to ensure reproducibility and throughput. Develop standard operating procedures (SOPs) for safe handling, storage, and disposal of raw materials and formulations. Collaborate with upstream ML lead on formulation design workflows that maximize our canvassing of chemical property space and support the generation of high-quality, broad-coverage training data. Characterizing formulation properties Assess viscosity, solubility, and other physiochemical features under different hydration and temperature conditions. Apply spectroscopy (UV-Vis, IR, fluorescence) to quantify molecular interactions and stability. Use calorimetry and thermal gravimetric analysis to measure thermodynamic and thermal stability profiles of formulations. Develop and validate assays to track long-term stability and degradation of formulations. Screening formulation-cargo interactions Design assays to evaluate compatibility of formulations with diverse small molecules, peptides, proteins, and nucleic acids. Measure cargo protection and stability (e.g., aggregation, precipitation, degradation) under varied conditions. Integrate biophysical characterization methods (DLS, CD, IR, LCMS) to assess cargo-formulation interactions. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Ph.D. in Organic Chemistry, Physical Chemistry, Chemical Engineering, Materials Science, or a related field + 5 years of experience (including 2 years of industry at minimum). Education may count towards years of experience. Extensive hands-on experience with formulation chemistry, high-throughput chemical screening, or analytical method development. Demonstrated expertise in chemical characterization techniques such as spectroscopy (UV-Vis, IR, NMR, fluorescence), calorimetry (DSC, ITC), and rheology. Proven ability to characterize physicochemical properties of complex mixtures under varying environmental conditions. Strong background in designing and executing high-throughput or automated experimental workflows. Committed team player with the ability to communicate and work collaboratively with ML scientists, lab scientists and operational team members. Prior leadership or team management experience preferred. Experience integrating benchtop experimental data into machine learning pipelines or predictive modeling workflows preferred. Strong understanding of thermodynamics, kinetics, and intermolecular interactions in multicomponent systems preferred. Familiarity with high-throughput robotics, automation platforms, or liquid handling systems for screening of solvents and liquids preferred. Knowledge of data analysis pipelines, including scripting skills (e.g., Python, R, MATLAB) for handling large experimental datasets preferred. Exposure to generative AI models for chemical discovery preferred. Experience working with biomolecules and protein chemistry preferred. Familiarity with principles of physical chemistry preferred. Experience in chemistry screening for personal care, nutrition, or aqueous coatings and adhesives preferred. LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TL1 The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL118 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL118's good faith estimate as of the date of publication and may be modified in the future.

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? Expedition Medicines Inc., is a privately held, early-stage biotechnology company pioneering the emerging field of Protein Editing. At Expedition Medicines we create small molecules that edit protein structure and function to unlock presently undruggable targets and a broad array of therapeutic modalities. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to enable generative design. Expedition Medicines is backed by Flagship Pioneering, bringing their courage, vision, and resources to guide Expedition Medicines from platform validation to patient impact. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! THE ROLE The Formulation team is seeking a highly motivated, attentive and self-driven candidate to join our team and contribute to the development of discovery compounds as an Senior Research Associate/Associate Scientist. This successful candidate will join an energizing and collaborative research environment working as part of cross function drug discovery teams in providing a develop-ability assessment of innovative molecules. KEY RESPONSIBILITIES Execute stage appropriate, fit-for-purpose preclinical formulations preparation (Solutions, suspensions, emulsions, nanoparticles, SEDDS etc.) for oral, and parenteral formulations on a small scale for small molecules Author protocols describing preparation of formulations for use at internal and external formulation labs Basic drug substance characterization by using techniques such as HPLC/UPLC, XRPD, DSC and PLM. Assessment of the chemical and physical properties of small molecules, such as solubility, dissolution, particle size and chemical stability Routine lab support such as buffer and mobile phase preparation, pH meter calibration, basic troubleshooting of lab equipment, and coordinating with external instrument and service vendors. Shipping and receiving samples between internal and external sites Summarize experimental results and presents at team meetings and department presentations Author templated memos and reports with limited guidance Maintain detailed lab notebooks and reports in compliance with GLP/GMP guidelines (as applicable) Evaluate novel drug delivery systems (e.g., lipid-based, amorphous solid dispersions, spray dry etc.) for poorly soluble compounds Support transition of formulations from discovery to clinical development (e.g., bridging studies) Independently design and perform focused experiments that drive progress in cross-functional formulation initiatives PROFESSIONAL EXPERIENCE & QUALIFICATIONS B.S. or M.S. in Chemistry, Biochemistry, Chemical Engineering, or a related discipline is required Three years minimum of industry, government or equivalent experience in small molecules formulation or a related field Hands-on experience with one or more of the following techniques: HPLC, UV-visible, DSC etc Experience with data analysis using standard software platforms (Excel, Prism etc.) Practical experience in developing and preparing preclinical formulations (small molecules) Basic knowledge of physicochemical properties and their relationship to formulation development Basic knowledge of pharmacokinetics (PK) and biopharmaceutics principles The ability to manage multiple parallel activities and deliver results to agreed timelines Ability to do bench work independently Strong collaboration, problem-solving, and adaptability in fast-paced research environments Excellent written, oral, and visual communication skills Excellent time management skills LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-MB1 The salary range for this role is $81,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Expedition Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Expedition Medicine's good faith estimate as of the date of publication and may be modified in the future.

Company Each day, the lives of more than 2 billion people across the globe are impacted by chronic diseases. Moreover, the economic burden on society of treating chronic disease is spinning out of control. Today, this dire situation appears unlikely to change as >95% of global healthcare costs are spent on treating rather than preventing chronic diseases. Etiome is a privately held early-stage company that is applying advanced biological and computational platforms to discover breakthroughs in detection of and intervention against the etiologies that drive progression from health to disease. Our goal is to leverage our proprietary platforms to disrupt the current approach of treating chronic disease after symptoms onset. We endeavor to provide true health care rather than sick care to individuals that are at risk of progressing to disease. Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** Position Summary: Etiome is seeking a highly motivated and experienced scientist focusing on neurobiology. Responsibilities: Planning, executing, and analyzing hands-on, wet-bench experiments involving primary and iPSC-derived neural cell types including but not limited to MEA studies, sc/sn RNAseq studies, immunohistological studies, etc. Culturing and maintaining primary and iPSC-derived cell cultures, including co-cultures and organoids Planning, executing, and analyzing in vivo studies focused on neurobiology Analyzing and interpreting single cell/single nuclei RNAseq studies Interpreting, organizing, and presenting biological data Maintaining good documentation Requirements: Expertise in neuroscience and neurodegenerative disorders, preferably Alzheimer's Disease Ph.D. in Neurobiology, biology, molecular biology, cellular biology or similar with 0-4 Years of experience post Ph.D. Hands on experience with in vitro assays using iPSC-derived neurons and relevant co-cultures, microelectrode array technology, beta amyloid and/or tau seeding assays, etc. Hands on experience with Alzheimer's Disease relevant in vivo mouse models Experience with bulk and single cell/single nuclei RNAseq data generation and data analysis workflows Strong organization and time management skills Strong oral and written communication skills Attention to detail and good documentation practices About Flagship Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $100,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Etiome, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Etiome, Inc.'s good faith estimate as of the date of publication and may be modified in the future.

FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. FL87, Inc was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture. Position Summary: We are seeking a highly motivated Associate Scientist of Immunology to join our therapeutic discovery team. The candidate will focus on hands-on benchwork using in vitro and ex vivo experimental approaches. The candidate must be independent, goal oriented, technically competent and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in immunology, cancer immunotherapy, and/or autoimmune diseases, who are comfortable working in a fast-paced entrepreneurial environment. Key Responsibilities: Independently design and execute in vitro assays to evaluate immune cell function, including multi-color flow cytometry, cytotoxicity assays and other functional readouts under the guidance of scientists Conduct ex vivo analysis of immune cells through tissue processing and downstream assays and analyses Develop, execute, and troubleshoot experimental protocols under the guidance of senior members on the team, and maintain accurate and timely electronic laboratory notebook records Analyze and communicate experimental data at team meetings Qualifications: BS or MS degree in biology, immunology, bioengineering or related discipline with 8+ years of relevant industry experience in immunology and/or immunotherapy. Strong experimental skills, including tissue culture, primary immune cell culture, flow cytometry, immunoassay development, and ex vivo mouse model sample processing Experience with non-viral delivery technologies and nucleic acid modalities is preferred Experience with primary human and/or NHP T cells is preferred Detail oriented, self-motivated, and comfortable working with highly technical projects and personnel Highly adaptable and responsive to delivering challenging commitments Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $96,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL87 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL87's good faith estimate as of the date of publication and may be modified in the future.

FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. FL87, Inc was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture. Position Summary: We are seeking a highly motivated Associate Scientist of Immunology to join our therapeutic discovery team. The candidate will focus on hands-on benchwork using in vitro and ex vivo experimental approaches. The candidate must be independent, goal oriented, technically competent and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in immunology, cancer immunotherapy, and/or autoimmune diseases, who are comfortable working in a fast-paced entrepreneurial environment. Key Responsibilities: * Independently design and execute in vitro assays to evaluate immune cell function, including multi-color flow cytometry, cytotoxicity assays and other functional readouts under the guidance of scientists * Conduct ex vivo analysis of immune cells through tissue processing and downstream assays and analyses * Develop, execute, and troubleshoot experimental protocols under the guidance of senior members on the team, and maintain accurate and timely electronic laboratory notebook records * Analyze and communicate experimental data at team meetings Qualifications: * BS or MS degree in biology, immunology, bioengineering or related discipline with 8+ years of relevant industry experience in immunology and/or immunotherapy. * Strong experimental skills, including tissue culture, primary immune cell culture, flow cytometry, immunoassay development, and ex vivo mouse model sample processing * Experience with non-viral delivery technologies and nucleic acid modalities is preferred * Experience with primary human and/or NHP T cells is preferred * Detail oriented, self-motivated, and comfortable working with highly technical projects and personnel * Highly adaptable and responsive to delivering challenging commitments Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $96,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL87 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL87's good faith estimate as of the date of publication and may be modified in the future.

Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. We are pioneering the development of Synteins™, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional scientists who are passionate about driving therapeutic modality innovation in biotechnology. Abiologics was founded in Flagship Pioneering's venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines were conceived and created. Since Flagship's founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents. THE ROLE We are seeking a biochemist to design, develop, and execute biochemical and biophysical strategies that enable the discovery and optimization of Synteins. The ideal candidate brings hands-on expertise in assay development, primary and secondary biochemical screening, and orthogonal biophysical characterization to establish target engagement, binding kinetics/thermodynamics, and mechanism of action. This role is highly collaborative, partnering closely with medicinal chemistry, computational sciences, and pharmacology. KEY RESPONSIBILITIES Design, develop, and validate robust biochemical and biophysical assays for hit identification, hit triage, and lead optimization across diverse target classes (enzymes, PPIs, receptors, and challenging targets). Execute and analyze small- to medium-scale screens including development of counterscreens and artifact mitigation strategies. Perform quantitative biophysical characterization of ligand-target interactions, including affinity, kinetics, stoichiometry, and thermodynamics. Apply a range of techniques such as SPR/BLI, fluorescence-based assays, and mass-spectrometry based assays; leverage orthogonal methods to confirm binding and establish MOA. Ensure data quality and rigor through appropriate controls, reference standards, Z' factor assessments, and comprehensive data QC and troubleshooting. Miniaturize and automate assays as appropriate; partner with automation/HTS teams and operate plate readers and liquid handling platforms. Analyze, visualize, and interpret complex datasets; summarize findings and recommend next steps to project teams. Proactively evaluate new technologies and methods to improve throughput, sensitivity, or mechanistic insight. Maintain accurate electronic lab notebooks, author SOPs, and present results to cross-functional stakeholders. PROFESSIONAL EXPERIENCE & QUALIFICATIONS PhD in Biochemistry, Biophysics, Chemical Biology, or related field with 0-1+ year of relevant experience; or MS with 6+ years; or BS with 8+ years in industry or equivalent. Demonstrated, hands-on experience developing and running biochemical and/or biophysical assays to quantify ligand binding and target engagement. Proficiency with core biophysical platforms (preferably BLI/SPR) and biochemical readouts (e.g., FP, TR-FRET/HTRF, AlphaLISA, enzymatic kinetics). Track record of troubleshooting complex assay and protein reagent issues and delivering decision-enabling data on tight timelines. Excellent communication and collaboration skills; ability to work effectively in cross-functional, fast-paced environments. LOCATION: Boston, MA ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-MB1 The salary range for this role is $96,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Abiologics, Inc currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Abiologics, Inc's good faith estimate as of the date of publication and may be modified in the future.

FL87, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. It was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture. The role We are seeking an experienced Lipid Nanoparticle (LNP) Formulation Scientist to drive the design, execution, and analysis of Design of Experiments (DOE) aimed at innovating next-generation LNP formulations. This role will play a critical part in developing, optimizing, and characterizing LNP systems for nucleic acid delivery in a fast-paced, collaborative research environment. Key responsibilities Design, execute, and analyze DOE-based formulation experiments to develop and optimize novel LNP formulations Lead formulation innovation efforts, including lipid selection, composition optimization, and process parameter evaluation Perform LNP screening and characterization, including size, PDI, encapsulation efficiency, stability, and performance metrics Apply strong analytical and statistical approaches to interpret complex datasets and guide formulation decisions Collaborate closely with cross-functional teams (biology, analytics, process development, and project management) to advance programs Maintain thorough experimental documentation and clearly communicate results and recommendations to stakeholders Contribute to troubleshooting formulation challenges and continuously improve experimental workflows Support scale-up considerations and technology transfer as needed Professional experience and qualifications PhD or MS in Chemistry, Pharmaceutical Sciences, Chemical Engineering, Materials Science, or a related field Strong hands-on experience with LNP formulations, including formulation development and optimization Demonstrated expertise in DOE methodologies and statistical experimental design Extensive experience with LNP screening and analytical techniques (e.g., DLS, encapsulation assays, stability studies, physicochemical characterization) Deep understanding of lipid-based delivery systems and formulation science principles Proven ability to work effectively in a team-oriented, fast-paced environment Strong problem-solving skills and ability to manage multiple priorities simultaneously Strong communication skills for presenting data and influencing technical decisions What We Offer Opportunity to work at the forefront of LNP formulation innovation Collaborative, science-driven culture with high impact research Competitive compensation and benefits package ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE Change the World list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company annual list of the World Most Innovative Companies. Learn more about Flagship *********************************************************************************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. The salary range for this role is $100,000 - $143,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL87 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL87's good faith estimate as of the date of publication and may be modified in the future.

Our start-up is building a novel chemical discovery platform to reshape how we develop formulations at the molecular level. By combining artificial intelligence with a cutting-edge laboratory discovery pipeline, our interdisciplinary team will chart an unexplored chemical landscape, enabling breakthroughs in drug delivery, agrichemical formulation, and safe, high-performance industrial chemicals. Our company is backed by Flagship Pioneering, a biotechnology origination company that has founded and developed over 115 scientific ventures over the past 25 years. Flagship Pioneering is dedicated to the development of an ecosystem of first-in-category life sciences companies, resulting in $20+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. THE ROLE We are seeking a motivated ML Scientist to lead the predictive pipeline of a lab-in-the-loop platform for novel chemistry. You will define and implement models that reason through the physical rules that govern chemistry to predict the properties of physiochemical interactions at the molecular level. The ideal candidate is eager to take the lead on building a chemistry discovery platform from scratch and be the team's computational visionary. KEY RESPONSIBILITIES Develop models that predict phase behaviors and physiochemical properties of chemical mixtures across temperature, hydration, and concentration gradients Build a generative “lab-in-the-loop” modeling pipeline, that incorporates human input of the chemical formulation scientist as well as experimental feedback and proposes the next set of experimental samples to be tested in the wet lab Build on top of next-generation chemistry ML methods, such as chemical LLMs, reaction prediction, and electronic structure methods like DFT Own the data flow pipeline, including definition of data standards and processing, data distribution analysis, and visualization to guide the team and inform decision-making processes PROFESSIONAL EXPERIENCE & QUALIFICATIONS PhD (or equivalent experience) in machine learning, computational chemistry, organic chemistry, chemical engineering, materials science, or related field Strong experience in building, training, and validating ML models in chemistry, material science, or related domains Knowledge of fundamentals of chemical properties is essential Proficiency in Python-based deep-learning frameworks (e.g. torch, pytorch lightning), ML logging software (e.g. MLFLow, WandB), relevant scientific libraries for chemistry (e.g. RDKit), and hyper-parameter optimization (e.g. Optuna) Ability to set up and maintain python compute environments Strong code organization and reproducibility work ethics and usage of git-based workflows Familiarity with cloud/HPC frameworks (e.g. aws, azure), containerization (e.g. docker), and batch compute Experience handling large, noisy experimental datasets Strong team player: ability to communicate and work hand-in-hand with chemists, lab scientists, and operational team members Experience with DFT and molecular dynamics tools preferred Experience in Bayesian optimization, active learning, reinforcement learning preferred Prior work on lab-in-the-loop platforms or early-stage teams preferred Knowledgeable in thermodynamics, statistical mechanics, and hydrogen-bonding interactions; familiarity with phase-diagram analysis preferred LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE's “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company's annual list of the World's Most Innovative Companies. Learn more about Flagship at *************************** At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact. We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. #LI-TL1 The salary range for this role is $132,000 - $209,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. FL118 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL118's good faith estimate as of the date of publication and may be modified in the future.