Formulation scientist job description

The incumbent will perform & coordinate developmental/experimental activities to support R&D activities in the research, preclinical within the research department supporting new formulation and process development. Will be a member of the extended project team and contribute in the lab as well as in technical documentation of activities, both in a notebook and online technical reports.
Major Job Functions

Designs and executes formulation, compatibility, and process studies to support phase appropriate development of NBPI’ s drug product portfolio. Duties will include, but not limited to design of programs, evaluation of data, recommendations on strategy, and authoring reports. Prepares technical reports and makes recommendations to senior management based on research outcomes. Manages and authors appropriate development reports and other documents for internal use and support of regulatory filings. Supports project activities and collaborates with colleagues in performing formulation, compatibility, and analytical studies as needed. Supports the organization in maintaining a safe working environment focused on quality and that fosters learning, respect, open communication, collaboration, integration, and teamwork. Sustains expertise and proficiency in parenteral drug product development. Sustains knowledge of formulation, process development. Sustains written and verbal communication skills to effectively interface across functional teams and present technical concepts and results. Sustains ability to identify and resolves critical issues, implement technical and operational plans. Sustains problem-solving skills and demonstrate good judgment and decision-making experience.


Education, Licensure and/or Experience

Academic qualifications (Ph.D. 3-5 years) in chemistry, bioengineering, chemical engineering or a closely related discipline. Formulation and product development experience (5 years) with drug delivery systems, biophysical, and molecular biology techniques. Hands-on experience with liposome or nanoparticle drug delivery systems. Basic knowledge of GMP and regulatory CMC. You will plan and perform laboratory formulation development and scale up experiments. Detail oriented and a highly meticulous laboratory approach.


Preferred Qualifications

Liposomal si RNA/mRNA/mi RNA/drug delivery experience. Familiarity with stages of the product development and cGMP concept. Knowledge of analytical methods for testing lipid nanoparticles. Understanding of the in-vitro and in-vivo experiments used for screening for candidate formulation. Knowledge of delivery systems incorporating polymers, conjugates and small molecules.


Physical Job Requirements:

Office/Lab environment. Lifting up to 20 pounds may be required. While performing the duties of this job, the employee is regularly required to use their hands and fingers to operate a computer keyboard, mouse, and telephone keypad or to write, as well as talk and hear. They are required to stand, walk or sit, reach with hands and arms, stoop, kneel, crouch or crawl. Specific vision abilities required by this job include close vision, distance vision, peripheral vision, depth perception and ability to focus
P-OCE-03

• PhD degree in Bio/Chemical Engineering, Pharmaceutical Sciences, Bio/Chemistry, or related scientific field or MSc with >5 years of relevant industry experience
• In-depth knowledge and hands on experience with proteins/small molecules/nucleic acids and/or liposome/lipid nanoparticle formulations development.
• Experience with process development, lyophilization, high-throughput screening and/or analytical characterization techniques (UV-Vis, fluorescence, particle characterization, DSC, chromatography, CryoEM, SAXS, rheological methods).
• Experience with GxP practices and basic laboratory management.
• Ability to connect team visions and complex goals with problem-solving and independent task management approaches.
• Ability to independently lead, design, conduct, and analyze experiments.
• Good organizational skills and the ability to manage multiple priorities in a fast-moving start-up environment.
• Excellent written and verbal communication skills.

Location: Cambridge, MA

More About Flagship Pioneering

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $50B in aggregate value. To date, Flagship has deployed over $2.2B in capital toward the founding and growth of its pioneering companies alongside more than $18B of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX).

Flagship Pioneering and our ecosystem companies are
committed to equal employment opportunity
regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies : Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Role purpose

Through a combination of world-class science and global expertise matched with investment in new and emerging technologies, Syngenta Professions Solutions (SPS) delivers innovative solutions to protect the places where you live, work and play. SPS encompasses three key business units, Professional Pest Management, Turf & Landscape, and Ornamentals, and we are seeking a Formulation Scientist for SPS product development to design and optimize formulation compositions to deliver active ingredients for effective pest control. More specifically the ideal candidate will have experience in bait formulation design, with a working knowledge of food science and entomology, along with knowledge of and experience in developing relevant agrochemical formulation types more generally, including granules, gels, suspension concentrates, emulsions, capsule suspensions, oil dispersions, etc.

The work will entail materials selection with an emphasis on physical and chemical characterization and formulation robustness testing to ensure ease of manufacture and final use by the customer. Additionally, the Formulation Scientist will work with interdisciplinary teams to characterize various aspects of performance, such as application, bioefficacy, safety, toxicity, and scale-up of the design. The Formulation Scientist's high-level responsibilities are development and stewardship of formulations from product conception and design to production and customer use.

Accountabilities

Plan, organize, and conduct experiments to design and optimize active ingredient formulations, meeting biology, marketing, regulatory, production, and supply chain criteria.

Validate formulation robustness through rigorous physico-chemical characterization.

Collaborate with engineering teams at pilot and production scale for introduction of newly developed products.

Mentor and coach other scientists within the SPS technical team and across the product development department.

Participate and communicate timely and effectively to technical and non-technical stakeholders on interdisciplinary project teams.

Coordinate and carry out laboratory work to develop new or improved manufacturing processes in support of global supply chains.

Steward local and global product portfolios and ensure product quality by designing and implementing new testing methods, in addition to supporting manufacturing and regulatory teams to ensure registrability and customer satisfaction of Syngenta products.

Define and implement innovative and creative solutions during product life-cycle development, and actively pursue opportunities for innovation and intellectual property independently and collaboratively.

Lead and prioritize multiple projects concurrently, and define challenging and ambiguous projects

Communicates effectively with technical and non-technical stakeholders.

Shows an aptitude to learn and apply new scientific disciplines, strategies, or technologies.

Employs organizational skills for proper time-management and clear communication of results.