Research Fellow jobs at Massachusetts Eye and Ear - 87 jobs

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The candidate will work within the Talkowski Laboratory in the Center for Genomic Medicine at Massachusetts General Hospital (MGH) and the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard. As a highly motivated, enthusiastic contributor, will work with our research group to detect, annotate, and characterize genetic variants in large cohorts of patients with autism and other neuropsychiatric conditions. The Talkowski Lab is a large, diverse, and interdisciplinary group of scientists dedicated to the characterization of genomic variation contributing to human disease. The group is leading and contributing to multiple international consortia that collect, process, aggregate, and analyze genomic sequencing data on a large scale. Will process incoming sequencing datasets through established pipelines and will contribute to the development of new analysis workflows. Effectively communicate with other subteams to ensure that new analysis workflows are distributed across teams. Perform high-quality, genome-scale computational analyses under the supervision of the group leader in a timely manner. Quickly learn new analytical approaches and be capable of applying and developing novel computational methods for solving complex problems. Must apply extensive practical programming experience, as well as experience with cloud computation and workflow management systems. Must also contribute experience with implementing large-scale computational analyses, algorithm development, or statistical analysis. Knowledge of existing analysis tools, methods, and databases in the field of genomics is a significant plus. This position is hybrid, with the option of flexible remote working hours. Essential Functions: * Serve as member of the team analyzing the sequencing data for the Autism Sequencing Consortium. Assist with the development of analysis aiming at (1) calling and annotating variants in short read sequencing data and (2) developing association frameworks to link detected variants to phenotypes. * Perform complex data acquisition, storage, cleaning, and pre-processing * Performs advanced quantitative statistical analysis methods * Dissemination of results via presentation and publications. * Process incoming blended genome exome (BGE) datasets (i.e., a cost-effective method that combines low-pass whole genome sequencing with deep exome sequencing from a single DNA sample) from various neuropsychiatric cohorts and calling copy-number variants in these samples. * Perform QC of results and generate reports to share with collaborators. * Interact with other subteams, most notably the methods development team, to develop, improve, standardize, optimize, and distribute new and existing methods for genomics analyses to bridge the progress made by different subteams. * Provide collaborative bioinformatics analysis in support of other research projects. * Track and communicate progress to internal and external stakeholders at meetings and over Slack. * Perform other responsibilities as needed. * Independently design and execute bioinformatics analyses and research projects on * small-mid scale projects. * Develop and optimize data analysis pipelines and workflows. * Collaborate with scientists and researchers to define analysis goals and interpret results. * Analyze data quality and integrity of data output from existing algorithms as part of the complex, multi-step specimen tracking and reporting process, across multiple systems and web-based interfaces. * Develop new and innovative tools to enhance quality assurance review and to improve assay and system performance. * Design and apply novel computational methods/bioinformatics algorithm, machine learning models for building data models and tools using various software and statistical tools to aid in the analysis and interpretation of genetic data, clinical data, images (NGS Algorithm development, Machine Learning). * Analyze large molecular datasets of tumor sequencing data to help critically review and analyze the results of specimen testing, working closely with faculty and staff to troubleshoot problems, recommend technology-based solutions, or determine computational strategies. Qualifications Education Master's Degree Computational Biology preferred or Bachelor's Degree Computational Biology required Experience Computational Sciences Experience 3-5 years required Knowledge, Skills and Abilities * Advanced skillset in computational biology, bioinformatics, statistics, or genomics. * Advanced knowledge of statistical association analyses and approaches in genomics studies * Experience in cloud-based computing preferred * Ability to adapt to shifting priorities in response to changing deadlines and the needs of the lab * Experience with cloud computing and workflow management systems. Experience with Terra, WDL, and Google Cloud is a plus. * Proficient in Python, R, and Unix/Linux, and/or other scripting languages. * Proven ability to learn new computational tools and packages. * Good foundations in statistics. * Ability to work independently and in a team setting in an organized fashion. * Good interpersonal and oral/written communication skills in English. * Strong ability and experience in interpreting computational results and translating these results into biologically relevant conclusions and hypotheses. * Experience in genomics and handling large-scale datasets is a plus. * Project management skills and/or experience is also a plus. Additional Job Details (if applicable) Remote Type Hybrid Work Location 185 Cambridge Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $92,102.40 - $134,056.00/Annual Grade 7 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: 1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary HOW TO APPLY: Interested applicants should email a cover letter and CV to Dr. Gary Brenner at *************************. The Mass General Brigham Department of Anesthesiology at Massachusetts General Hospital is seeking a Postdoctoral Research Fellow to conduct translational neuroscience related to development of a novel gene therapy for peripheral nerve tumors. The ideal person for this position should possess good organizational skills, pay close attention to details, and communicate well. The person must be able to work independently, as well as with a team. Qualifications HOW TO APPLY: Interested applicants should email a cover letter and CV to Dr. Gary Brenner at *************************. With supervision and guidance, responsibilities of the Postdoctoral Research Fellow will include: * Performs independent and highly specialized experimental procedures * Designs and implements modifications of research protocols * Troubleshooting problems and instructing colleagues in highly specialized techniques * Synthesizes and interprets results * Performs advanced data recording and analysis using various software programs and statistical techniques * Maintains organized and detailed records of laboratory experiments in electronic laboratory notebooks * Presents results at lab meetings and, as applicable, at national conferences * Preparation and submission of research manuscripts to peer-reviewed journals * Assistance with preparation of grant applications * Other duties as assigned SKILLS/ABILITIES/COMPETENCIES REQUIRED: A successful candidate will: * Work independently under general direction of the Principal Investigator * Be motivated, meticulous, organized, and detail-oriented * Demonstrate initiative and enthusiasm for learning new techniques * Have strong analytical and problem-solving skills * Possess strong technical abilities and computer science skills * Possess excellent written and oral communication skills as demonstrated by publications and presentations * Possess the ability to make independent and effective decisions in a timely fashion * Possess competence in research techniques and methodologies * Have excellent interpersonal skills * Be a team player who works well with other lab members * Possess and exhibit both scientific curiosity and integrity Additional Job Details (if applicable) LICENSES, CERTIFICATIONS, and/or REGISTRATIONS (if applicable): N/A EDUCATION: PhD and/or MD required in neuroscience, cancer biology, immunology, molecular biology, biochemistry, cell biology, or a related field. EXPERIENCE: Prior lab experience required. Must have evidence of strong scientific productivity, including peer-reviewed publications. Open to highly motivated candidates with a relevant background. Secondary appointment will be at Harvard Medical School. SUPERVISORY RESPONSIBILITY (if applicable): Assistance guiding research technicians and trainees in the lab is expected. FISCAL RESPONSIBILITY (if applicable): N/A WORKING CONDITIONS: Work will be performed in a fast-paced research laboratory environment, requiring teamwork, collaboration, and flexibility. Candidate must be able to work independently. Remote Type Onsite Work Location 15 Parkman Street EEO Statement: 1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts Eye and Ear Infirmary Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Summary Will conduct independent and collaborative research, contributing to the advancement of knowledge and the development of innovative solutions. The fellow will work under the supervision of the Principal Investigator and collaborate with a team of researchers. Does this position require Patient Care? No Essential Functions * Design, plan, and execute research experiments or projects in alignment with departmental goals. * Gather, analyze, and interpret data using appropriate statistical methods and tools. * Conduct comprehensive literature reviews to inform research direction and methodologies. * Prepare and publish research findings in peer-reviewed journals and present at conferences and seminars. * Work collaboratively with faculty, students, and other researchers, contributing to a positive research environment. * Mentor graduate and undergraduate students, providing guidance on research methodologies and techniques. * Assist in the preparation of grant proposals and funding applications to support ongoing research. * Prepare periodic reports and documents summarizing research progress and outcomes. Qualifications Education Doctorate Related Field of Study required Can this role accept experience in lieu of a degree? No Licenses and Credentials Experience Previous Research experience 3-5 years preferred Knowledge, Skills and Abilities * Demonstrated experience in research techniques, methods, or research areas relevant to the project. * Proficient analytical skills, proficiency in statistical software, and excellent written and verbal communication skills. * Ability to work independently as well as collaboratively within a team. * Good interpersonal and communication skills. Additional Job Details (if applicable) The Shalhout Lab is recruiting a highly motivated postdoctoral fellow with expertise in small molecule drug discovery, molecular biology, biochemistry, and/or chemistry. Our group is developing innovative approaches to treat cancers by combining cutting-edge experimental biology with computational biology. We are seeking candidates with strong wet-lab skills who are excited to design, execute, and interpret experiments that drive therapeutic discovery. ESSENTIAL FUNCTIONS: * Design and perform biophysical and biochemical assays, including protein purification, binding/interaction studies, cell reporter assays, and enzymatic assays. Purify and characterize proteins for structural and functional studies. * Design and perform protein-protein and protein-ligand interactions (e.g., SPR, ITC, pull-downs, FRET). * Conduct cell-based functional assays such as reporter assays, qPCR, and molecular characterization of signaling pathways. * Carry out molecular biology techniques, including cloning, mutagenesis, and protein expression. Perform mutagenesis and structure-function studies to map binding sites and mechanisms of action. * Support hit validation and lead optimization through iterative testing of small molecules. * Collaborate with medicinal chemistry and computational teams to prioritize candidates and refine drug design. * Basic understanding of biostatistics * Analyze and interpret experimental data, present findings in lab meetings, publications, and conferences. * Collaborate with team members on projects linking experimental data to translational cancer research EDUCATION AND EXPERIENCE: PhD in a relevant field (Molecular Biology, Biochemistry, Biophysics, Cancer Biology, or related discipline) with a strong track record of peer-reviewed publications in areas such as drug discovery, small-molecule therapeutics, or translational oncology research. WORKING CONDITIONS: Dry and potentially wet lab setting. Remote Type Onsite Work Location 20 Staniford Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: 5110 Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. LW, 100% research funded research fellow Job Summary The Division of General Internal Medicine and Primary Care, Department of Medicine at Brigham and Women's Hospital (BWH) and Harvard Medical School (HMS), invites applications for a postdoctoral fellowship in medical informatics. The Division is nationally recognized for providing compassionate, high-quality care, pioneering innovative medical education, and conducting cutting-edge clinical and health services research. We are seeking one highly motivated, diligent, and independent Research Fellow to join a dynamic research team supported by grants from the National Institutes of Health (NIH). This position focuses on advancing biomedical informatics research by applying artificial intelligence (AI) techniques and longitudinal electronic health records (EHRs) for disease phenotyping, risk factor identification, patient stratification, and predictive modeling. The successful candidate will design, develop, and evaluate innovative methods for data mining and analytics, leveraging comprehensive clinical knowledge bases, advanced natural language processing (NLP)/large language models (LLMs), and machine learning techniques. The ultimate goals are to drive knowledge discovery, improve clinical decision-making, enhance patient safety, and elevate the quality of care. The fellowship is based at Brigham and Women's Hospital, Harvard Medical School, and Mass General Brigham, offering a collaborative, multidisciplinary environment at the forefront of health information technology research. Fellows will have the opportunity to engage in groundbreaking research, contribute to ongoing projects, and propose novel research initiatives with the potential to secure external funding. During the appointment period, Fellows will be strongly encouraged to publish their research findings in high-impact journals and present their work at national and international conferences. This opportunity is ideal for individuals who are both independently driven and collaborative, thriving in a vibrant research environment alongside a large team of experienced faculty and staff. Fellows must be comfortable giving and receiving constructive feedback, incorporating insights to improve their work, and transparently sharing their ideas and decision-making processes. Recognizing and valuing the contributions of colleagues is essential, as is the ability to communicate effectively within a diverse, multidisciplinary team. Qualifications General Summary/Overview Statement Summarize the nature and level of work performed The Division of General Internal Medicine and Primary Care, Department of Medicine at Brigham and Women's Hospital (BWH) and Harvard Medical School (HMS), invites applications for a postdoctoral fellowship in medical informatics. The Division is nationally recognized for providing compassionate, high-quality care, pioneering innovative medical education, and conducting cutting-edge clinical and health services research. We are seeking one highly motivated, diligent, and independent Research Fellow to join a dynamic research team supported by grants from the National Institutes of Health (NIH). This position focuses on advancing biomedical informatics research by applying artificial intelligence (AI) techniques and longitudinal electronic health records (EHRs) for disease phenotyping, risk factor identification, patient stratification, and predictive modeling. The successful candidate will design, develop, and evaluate innovative methods for data mining and analytics, leveraging comprehensive clinical knowledge bases, advanced natural language processing (NLP)/large language models (LLMs), and machine learning techniques. The ultimate goals are to drive knowledge discovery, improve clinical decision-making, enhance patient safety, and elevate the quality of care. The fellowship is based at Brigham and Women's Hospital, Harvard Medical School, and Mass General Brigham, offering a collaborative, multidisciplinary environment at the forefront of health information technology research. Fellows will have the opportunity to engage in groundbreaking research, contribute to ongoing projects, and propose novel research initiatives with the potential to secure external funding. During the appointment period, Fellows will be strongly encouraged to publish their research findings in high-impact journals and present their work at national and international conferences. This opportunity is ideal for individuals who are both independently driven and collaborative, thriving in a vibrant research environment alongside a large team of experienced faculty and staff. Fellows must be comfortable giving and receiving constructive feedback, incorporating insights to improve their work, and transparently sharing their ideas and decision-making processes. Recognizing and valuing the contributions of colleagues is essential, as is the ability to communicate effectively within a diverse, multidisciplinary team. Principal Duties and Responsibilities Indicate key areas of responsibility, major job duties, special projects and key objectives for this position. These items should be evaluated throughout the year and included in the written annual evaluation. For all positions that include direct patient care, indicate with an "X" the age(s) of all patient populations served No Direct Patient Care X All age groups Adolescence (13 to 17 years) Neonates (birth to 1 month) Young Adult (18 to 25 years) Infant (1 month to 1year) Adult (26 to 54 years) Early Childhood (12 months to 5 years) Senior Adult (55 to 64 years) Late Childhood (6 to 12 years) Geriatric (65 years and up) The duties and responsibilities will vary depending on the specific topic area in which the fellow works, but will generally include: * Collaborating with a multidisciplinary team of researchers, clinicians, and data scientists to achieve project goals. * Participating in the design, development, implementation, and evaluation of proposed system and methods. * Leading or contributing to the design and development of novel AI/informatics methods and applications. * Conducting data analysis and system evaluation. * Leading or contributing to manuscript preparation, writing, and submission to peer-reviewed journals. * Presenting research findings at national and international conferences, seminars, and workshops. Qualifications (MUST be realistic, neither overstated nor understated, and related of the essential function of the job). * A PhD in biomedical informatics, computer science, information science, computational linguistics, statistics, data science, or a closely related field; or an MD/PharmD with demonstrated strength in biomedical informatics research. * Experience in biomedical informatics research; ability to plan and carry out research experiments and projects. * Candidates with experience in the areas of medical terminologies/ontologies, natural language processing/large language models, and machine/deep learning are strongly encouraged to apply. * Programming experience in computer programming languages (e.g., Python, Java, C#, SQL, R, etc). * Familiar with machine learning and statistical informatics methods. * Experience of analyzing healthcare data (e.g., EHR, claims) are desirable, but not required. Application materials: * Cover letter * CV * Three Letters of reference preferred, or contact info of references * Sample publication with clearly stated individual contributions Skills/Abilities/Competencies Required (MUST be realistic, neither overstated nor understated, and related of the essential function of the job). * Programming skills in computer programming languages (e.g., Python, Java, or C) and experience in artificial intelligence model development. * Experience in machine learning and statistical methods. * Excellent oral and written communication skills. * Ability to accept and adjust to feedback from supervisors. * Professionalism, respect, and regard for patient privacy. * Outstanding team player with the ability to thrive in a dynamic environment and adapt to shifting priorities, demands, and timelines. * Strong organizational skills and time management abilities. * Ability to prioritize tasks and meet deadlines. * Strong work ethic and industrious nature. Additional Job Details (if applicable) Remote Type Hybrid Work Location 1620 Tremont Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: 2200 The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts Eye and Ear Infirmary Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary POSITION SUMMARY: Proposes and undertakes a mentored, innovative project or challenge to develop novel therapy for neurotrophic keratopathy. Designs and performs in vitro and animal experiments, analyzes and presents the outcome. Candidates with a background in Bioengineering that have specialized in microfluidics and have experience with stem cell research and microparticle analysis are strongly preferred. ESSENTIAL FUNCTIONS: Read, analyze and summarize published literature Design and execute in vitro and in vivo Undertake relevant coursework if required by mentor. Attend relevant meetings Meet regularly with mentor to review project progress and milestones Plan and deliver a seminar on the project Take administrative (inventory, purchasing, etc. ) responsibilities in the lab when necessary Write a final report or submit a manuscript to a peer-reviewed journal describing the project and results Qualifications EDUCATION AND EXPERIENCE: Doctoral degree (MD or PhD) with more than 1 year of lab experience. WORKING CONDITIONS: Lab setting. PHYSICAL REQUIREMENTS: Possible lifting of 10 to 20 lbs., depending on nature of chosen project(s). Additional Job Details (if applicable) Remote Type Onsite Work Location 20 Staniford Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Courtesy posting Job Summary A postdoc position is open in the laboratory of Silke Nuber in the Ann Romney Center for Neurologic Diseases in the Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, to study alpha-synuclein biology in mice and cell culture models of Parkinson's disease (PD). The research focuses on determining whether gender or lipid-dependent changes that affect the alpha-synuclein tetramer:monomer ratio early in Parkinson's pathology confer neuroprotection to specific neurons and brain regions. The PI's previous work demonstrated that upstream abrogation of normal -synuclein tetramers, the key protein in Lewy body pathology, induces a progressive, L-DOPA-responsive motor syndrome and cortical and dopaminergic fiber loss in familial PD E46K ("1K") and "3K" mutant mice. The new project uses these unique mouse models to study early-onset synucleinopathy. In addition, new models will be generated to analyze tetramer abrogation by other familial PD -synuclein mutations. Effects include behavioral testing as well as molecular, biochemical and neuropathological analyses. Candidates must have extensive experience working with mice, including neonatal injections. Prior work with primary neurons and/or induced human neurons required. Only candidates with demonstrated expertise and publications in molecular biology, biochemistry, cell biology and animal husbandry should apply. Qualifications Requirements * A Ph.D. in neuroscience, biochemistry or a related biological field. * Excellent track record of publications, including in neurodegenerative disease. * Extensive experience with mouse studies, including behavior, listed in detail in the CV. * Experience in molecular biology, pathology and biochemistry, listed in detail in the CV. * Cell culture (primary neurons and/or induced human neurons) experience preferred, listed in detail in the CV. * Self-motivated and driven individual able to work both independently and in a team environment. * Excellent oral and written communication skills in English. * Minimum three-year commitment. Compensation will follow NIH postdoctoral stipend levels. Applicants should submit a cover letter detailing their research experience, a CV, a potential start date, and full contact information for three reference to; Dr. Silke Nuber (**********************) Karen Tobin (************************) Additional Job Details (if applicable) Remote Type Onsite Work Location 60 Fenwood Road EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The laboratory of Dr. Shiaulou Yuan at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) is seeking highly motivated candidates for a full-time postdoctoral research fellow position. We are a multidisciplinary group of biologists, biophysicists, and microscopists who aim to understand how fluid flows and biophysical forces shape the developing heart and how these mechanisms underlie cardiac disease pathogenesis when gone awry. Specifically, we seek to illuminate how the cilium, a hair-like structure found on most cells in the human body, acts as an "antenna" to sense and translate extracellular signals into molecular processes that sculpt the early heart (Djenoune, Mahamdeh et al., Science, 2023). The penultimate goal of our research is to advance our understanding of cardiac development and diseases by combining state-of-the-art approaches from developmental biology, cell biology, genetics, biophysics, and advanced microscopy in zebrafish animal models and human stem cells. This position offers excellent opportunities to work in a highly collaborative and multi-disciplinary biomedical atmosphere, interact with distinguished scientists, physicians and physician-scientists at MGH-Harvard, and become a valued member of a collegial and growing research team. As a member of Harvard University, Massachusetts General Hospital, Mass General Brigham, and the Boston scientific community, the candidate will be immersed in a rich environment for zebrafish genetics, cardiovascular biology, cilia signaling, molecular biology, and imaging technologies. Qualifications REQUIRED SKILLS AND EXPERIENCE The ideal candidate will have: * a strong background working with zebrafish * a PhD, MD, MD/PhD or equivalent doctoral degree in a relevant field * prior training in zebrafish husbandry and colony management, embryo micro-injection, embryo micro-dissection, confocal or light sheet microscopy, live cell imaging, quantitative image analysis, immunofluorescence, in situ hybridization, molecular cloning, CRISPR-Cas9 gene editing, recombinant protein, and/or human stem cell culture techniques * a passion for developmental biology, cell biology, cardiovascular biology, and microscopy * the ability to work independently and also as part of a team * excellent written and verbal communication skills * a strong work ethic and superb attention to details * exceptional technical and experimental skills. * experience training and supervising junior scientists, technicians and/or students Interested candidates should send a CV, a cover letter, and contact information for three references to Dr. Shiaulou Yuan (*****************************). Find out more about our lab's research: **************************** Review of applications will begin immediately and continue until the position is filled. Additional Job Details (if applicable) EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged. Remote Type Hybrid Work Location 185 Cambridge Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary "The George A. "Doc" Lopez, MD, Laboratory for Regenerative Cell Therapy" (Lopez Lab) in the Department of Neurosurgery at Massachusetts General Hospital (MGH), a teaching affiliate of Harvard Medical School in Boston, Massachusetts, USA seeks motivated candidates to join our team at the postdoctoral research level. In 2018, the Department of Neurosurgery, MGH and the Laboratory of Molecular Neurobiology at McLean Hospital, both affiliated with Harvard Medical School, jointly completed the world's first FDA-approved autologous hi PSC-differentiated dopamine precursor cell implantation for the treatment of Parkinson's disease (N Engl J Med. 2020; 382:20 1926-1932). In 2023, the George A. "Doc" Lopez Laboratory for Regenerative Cell Therapy was established in the Department of Neurosurgery at MGH in honor of this achievement, to support ongoing and future clinical trials of cell therapy for Parkinson's disease (NCT06687837), and to develop and implement next generation cell production methods and novel cell therapies. The laboratory also focuses on disease mechanisms as a basis for developing new therapies, with an emphasis on transformative translational applications to Parkinson's disease and related neurodegenerative diseases. The laboratory includes both a GMP facility to produce clinical-grade cells for human clinical trials, and a neurobiology laboratory for preclinical research. The Laboratory is jointly directed by Scientific Director Bin Song, MD, PhD and Clinical Director Jeffrey Schweitzer, MD, PhD, both Assistant Professors of Neurosurgery of Harvard Medical School, in the Departments of Neurosurgery at Mass General Brigham. The Laboratory website is: ************************************************************************************** Qualifications The Laboratory is now recruiting for 1 postdoctoral fellow. Candidate qualifications should include a PhD or MD degree in a relevant field such as neuroscience, stem cell biology, gene editing, immunology, cellular neurophysiology etc., with evidence of scholarly achievement including relevant publications. Familiarity with clinical neuroscience or other biological or medical backgrounds is preferred. Highly valued qualifications include: 1. Experience in stem cell culture and neuron differentiation 2. Experience in neurodegenerative disease animal models, neural circuit analysis, optogenetics, chemical genetics, or electrophysiology 3. Experience in gene editing, molecular biology 4. Experience in immunology 5. Teamwork spirit and communication skills Additional Job Details (if applicable) Application Process: Please send CV to Dr. Bin Song: ********************* or Dr. Jeffrey Schweitzer **************************** Massachusetts General Hospital is an affirmative action/equal opportunity employer and encourages applications from women and underrepresented minorities. Remote Type Onsite Work Location 55 Fruit Street EEO Statement: Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary We are seeking a highly motivated Postdoctoral Fellow to lead computational efforts focused on AI-accelerated drug discovery and delivery for neurological diseases. The ideal candidate will develop and apply cutting-edge machine learning methods to integrate multimodal and multiomics datasets, identify therapeutic targets/drugs, and design novel compounds, and leverage our unique in vitro models and in vivo nanotechnology tools. This role will involve driving high-impact, interdisciplinary research at the intersection of AI, single-cell omics, and translational neuroscience, with access to state-of-the-art resources and close collaboration with experimental teams generating novel datasets. Join our dynamic, multidisciplinary team as we develop new strategies to tackle neurodegeneration, together with the incredible collaborators and resources of the MGB/HMS/Broad/MIT ecosystem and partner biopharmaceutical companies. Responsibilities: * Integrate multimodal data and develop and train AI foundation models on large-scale biological datasets for predictive modeling of cellular responses, target identification, and drug candidate identification. * Apply generative and sequence-based ML models to design, model, and optimize binding peptides. * Analyze high throughput screens and biological datasets to inform in silico predictions. Qualifications Required Qualifications: * PhD in Computational Biology, Bioinformatics, Machine Learning, Computer Science, Statistics, or a related field (recently completed or near completion). * Strong publication record demonstrating expertise in ML applied to biology. * Expertise in Python; experience with deep learning frameworks (PyTorch/TensorFlow); single-cell genomics analysis (Seurat, Scanpy, sc VI, etc.); and perturbation modeling (e.g., GEARS, sc Gen). * Excellent organizational, communication, and teamwork abilities in a fast-paced research environment. * Interest in translational impact. Preferred Qualifications: * Experience with biological foundation models (e.g., sc GPT, Geneformer, sc BERT); generative AI for sequences/proteins/peptides (e.g., RFdiffusion variants); cheminformatics tools (e.g., RDKit, PubChem querying); active learning/uncertainty quantification; pipeline automation (e.g., custom scripts or Airflow); integration of public resources (e.g., OpenTargets, ChEMBL); or basic computational ADMET/pharmacokinetics assessment. * Background in neurodegenerative disease. * Wet lab skills in molecular and cellular biology, nanotechnology, and pharmacology. How to Apply: Please submit your CV, a cover letter detailing your relevant experience and interest in the project and contact information for three references to Alice Stanton at *************************. We look forward to having you join us in advancing the fight against neurological diseases! Additional Job Details (if applicable) Remote Type Onsite Work Location 185 Cambridge Street EEO Statement: Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Courtesy posting Job Summary This job involves working independently and under general supervision from the Principal Investigator on NIH-sponsored research. The primary goals of the Post Doctoral Fellow will be to lead the network data analysis in relation to cutting-edge research in neurology and network science. The Post-Doctoral Fellow will supervise and assist with this federally funded clinical studies which aim to investigate the relationships between patient's social networks and their clinical outcomes. Qualifications Primary responsibilities will include data analysis, academic writing, contributing to the overall research effort at the Dhand Lab, grant writing, attending conferences, participating in meetings with collaborators , and any other related duties assigned to the fellow by the PI . This position will provide the Post-Doctoral Fellow the opportunity to gain leadership skills and data analysis skills that could lead to academic presentations or publication opportunities. This job is well-suited for individuals interested in social networks, neurology, population health, and a career in academic research or data analysis. A background in either population health, epidemiology, biostatistics, computer science, or social science are beneficial. Interested applicants can learn more about the research team and its work by visiting ***************** PRINCIPAL DUTIES AND RESPONSIBILITIES: 1. Lead writing of academic articles. 2. Conduct data analysis for clinical research studies as per study guidelines and protocols. 3. Responsible for maintaining database for study. May be required to monitor data quality, maintain data analysis records, and create data reports. 4. Code and completes analyses related to project in the R environment and other software platforms. 5. Strong interest in contributing to the overall scientific literature especially in interdisciplinary research with journals in neurology, neuroscience, social network sciences, network science, and population health. 6. Attend required meetings with PI and collaborators. 7. All other duties, as assigned. QUALIFICATIONS: Doctoral Degree in either epidemiology, biostatistics, population health, social sciences, physics, or related fields. Sound independent judgment, knowledge and experience in data analysis and competence in research methodologies. SKILLS/ ABILITIES/ COMPETENCIES REQUIRED: 1. Ability to work independently. 2. Good oral and written communication skills. 3. Analytical skills and the ability to resolve technical or research problems and issues and to interpret the acceptability of data results. 4. Knowledge of clinical research protocols. 5. High degree of data analysis. 6. Excellent organizational skills and ability to prioritize a variety of tasks. 7. Careful attention to detail. 8. Ability to demonstrate professionalism and respect for subjects' rights and individual needs. 9. Knowledge of data management programs. 10. Experience in scientific writing. If interested in applying, please submit CV and Cover Letter to CVs: Vrushali Dhongade (*************************) and Dr. Amar Dhand (**********************). Additional Job Details (if applicable) Default Add'l Job Description Remote Type Hybrid Work Location 75 Francis Street EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts Eye and Ear Infirmary Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary We have an open position for a computer science/machine-learning postdoctoral fellow to work on machine-learning algorithms for automatic diagnosis of dystonia, prediction of the risk for dystonia development, and the efficacy of treatment outcomes. This work will be directly related to the extension of our recently developed DystoniaNet platform and will include brain MRI datasets from patients with dystonia, other movement disorders, and healthy individuals. The postdoctoral fellow will be part of a multidisciplinary team of neuroscientists, neurologists, laryngologists, and geneticists at Mass Eye and Ear and Mass General Hospital and work at the intersection on the development, testing and implement of DystoniaNet in the clinical setting. This position is best suited for an individual with a broad computer science background interested in understanding and examining critical clinical problems and developing research solutions for their translation to healthcare. The fellow will be highly competitive to pursue future opportunities in either academia or industry (pharma and biotech). Qualifications Postdoctoral Fellow in Deep Learning We have an open position for a computer science/machine-learning postdoctoral fellow to work on machine-learning algorithms for automatic diagnosis of dystonia, prediction of the risk for dystonia development, and the efficacy of treatment outcomes. This work will be directly related to the extension of our recently developed DystoniaNet platform and will include brain MRI datasets from patients with dystonia, other movement disorders, and healthy individuals. The postdoctoral fellow will be part of a multidisciplinary team of neuroscientists, neurologists, laryngologists, and geneticists at Mass Eye and Ear and Mass General Hospital and work at the intersection on the development, testing and implement of DystoniaNet in the clinical setting. This position is best suited for an individual with a broad computer science background interested in understanding and examining critical clinical problems and developing research solutions for their translation to healthcare. The fellow will be highly competitive to pursue future opportunities in either academia or industry (pharma and biotech). Responsibilities include but may not be limited to * Experimental data collection and processing * Development and refinement of deep learning and other benchmark algorithms for predictive classification of dystonia and other related disorders * Clinical translation and implementation of the developed algorithms and interactions with clinicians for their testing * Establishment of new and fostering of existing collaborations * Participation in the regulatory aspects of clinical translation and patenting * Presentation of the results at the scientific meetings and publication of journal articles * Mentoring junior staff Qualifications and Skills * PhD or an equivalent degree in computer science, neuroscience, biomedical engineering, or related fields * Broad proficiency and experience with supervised and unsupervised machine-learning methods, expertise in building neural network architectures * Experience with neuroimaging data processing * Advanced programming skills (Python and/or Matlab), including deep learning packages (e.g., TensorFlow or Keras) * Knowledge and experience with cloud-based computational platforms (e.g., AWS) * Excellent verbal and written communication skills * Strong publication record and academic credentials * Ability to work effectively both independently and in collaboration with multiple investigators Additional Job Details (if applicable) Remote Type Onsite Work Location 243-245 Charles Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts Eye and Ear Infirmary Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Postdoctoral Fellow in ECoG/LFP of Speech Control An NIH-funded postdoctoral fellow position is available to study speech control in patients with dystonia and tremor using a combination of electrocorticography/local field potential (ECoG/LFP), electroencephalography (EEG), structural (MRI, DWI) and functional (fMRI, EEG) neuroimaging, and clinical-behavioral neurotesting. The postdoctoral fellows will function as part of a multi-disciplinary team of neuroscientists and clinicians. Responsibilities include participating in all aspects of data acquisition and management; developing, modifying, and executing analytical protocols; preparing publications and scientific presentations; disseminating results in peer-reviewed scientific journals and at major national and international meetings, and mentoring junior staff. Opportunities exist for excellent scientific interactions and collaborations with an extensive program of seminars, symposia, and other meetings focused on a large array of topics in neuroscience, neurosurgery, clinical research, and neurotechnology. Qualifications Education Can this role accept experience in lieu of a degree? Licenses and Credentials Experience Knowledge, Skills and Abilities Additional Job Details (if applicable) Postdoctoral Fellow in ECoG/LFP of Speech Control An NIH-funded postdoctoral fellow position is available to study speech control in patients with dystonia and tremor using a combination of electrocorticography/local field potential (ECoG/LFP), electroencephalography (EEG), structural (MRI, DWI) and functional (fMRI, EEG) neuroimaging, and clinical-behavioral neurotesting. The postdoctoral fellows will function as part of a multi-disciplinary team of neuroscientists and clinicians. Responsibilities include participating in all aspects of data acquisition and management; developing, modifying, and executing analytical protocols; preparing publications and scientific presentations; disseminating results in peer-reviewed scientific journals and at major national and international meetings, and mentoring junior staff. Opportunities exist for excellent scientific interactions and collaborations with an extensive program of seminars, symposia, and other meetings focused on a large array of topics in neuroscience, neurosurgery, clinical research, and neurotechnology. Qualifications and Skills * A PhD or MD/PhD degree in Neuroscience, Biomedical Engineering, Mathematics, or related fields of biomedical sciences * Expertise in ECoG/LFP data processing and other methods of human brain imaging, including but not limited to fMRI, EEG, and DWI * Solid experience with scientific computing, including but not limited to computational (Python, MATLAB) and statistical (AFNI, FSL, SPM) methods * Strong experience in algorithmic design, mathematical models (primarily stochastic differential equation systems), and analysis and integration of dynamical systems * Independence and professional self-motivation with a proven track record of productive research * Ability to work effectively independently and collaborate on projects with multiple investigators * Strong written and verbal communication skills * Excellent academic credentials, including a strong publication record Remote Type Onsite Work Location 243-245 Charles Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. The Research Fellow will play a crucial role in the MGH Cardiovascular Research Center's Wyant Lab. The scientific mission of the Wyant Lab is to understand the mechanism by which key physiological inputs, such as oxygen, nutrients, mechanical stretch, and electrical signals regulate heart, muscle, and brain function. The goal is to ultimately identify novel therapeutic strategies for heart failure, neurodegeneration, or muscle atrophy. We are particularly interested in candidates with prior experience in Crispr-Cas9 genetic screening technologies, protein purification and structural biology, and mouse physiology. Qualified candidates with a PhD should send their CV and a cover letter to Dr. Gregory Wyant at **********************. Job Summary Summary Does this position require Patient Care? No Essential Functions Qualifications Education: PHD Can this role accept experience in lieu of a degree? No Licenses and Credentials Experience Knowledge, Skills and Abilities Additional Job Details (if applicable) Physical Requirements * Standing N/A = (0%) * Walking N/A = (0%) * Sitting N/A = (0%) * Lifting N/A = (0%) * Carrying N/A = (0%) * Pushing N/A = (0%) * Pulling N/A = (0%) * Climbing N/A = (0%) * Balancing N/A = (0%) * Stooping N/A = (0%) * Kneeling N/A = (0%) * Crouching N/A = (0%) * Crawling N/A = (0%) * Reaching N/A = (0%) * Gross Manipulation (Handling) N/A = (0%) * Fine Manipulation (Fingering) N/A = (0%) * Feeling N/A = (0%) * Foot Use N/A = (0%) * Vision - Far N/A = (0%) * Vision - Near N/A = (0%) * Talking N/A = (0%) * Hearing N/A = (0%) Remote Type Onsite Work Location 149 Thirteenth Street Building 149 Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The Psychiatry Neuroimaging Laboratory at Brigham and Women's Hospital is seeking a full-time Postdoctoral Research Fellow to join our growing team. The fellow will work under the primary mentorship of Dr. Johanna Seitz-Holland, with additional guidance from Dr. Marek Kubicki. The fellow will be working on several funded projects examining psychosis across the lifespan using neuroimaging, clinical, and blood protein data. This is an exciting opportunity to contribute to impactful research while developing a strong foundation in translational psychiatry. We are a dynamic team committed to fostering a collaborative, supportive, and intellectually curious environment. Dr. Seitz-Holland takes mentoring seriously and is dedicated to creating a positive work atmosphere where team members can grow professionally and personally. We welcome applicants who are motivated, eager to learn, and excited to be part of a team working toward meaningful change in mental health research.The fellow will also have the opportunity to participate in the Stuart T. Hauser Research Training Program in Biological and Social Psychiatry (T32 position), which provides further structured training and career development support. Responsibilities include, but are not limited to: Assisting with quality control and curation of data collected as part of the psychosis projects. Processing imaging and blood data. Analyzing and modeling complex datasets, including neuroimaging, behavioral, and clinical data. Presenting at national and international meetings and building an active research/publication record. Assisting with grant writing. Supervising research assistants and undergraduate research trainees. Actively participating in the T32 training program. Qualifications Requirements: Ph.D. in Neuroscience, Clinical Neuroscience, Cognitive Science, Psychology, Engineering, Computer Science, or a related field. Background in data processing, statistics, biostatistics, or data modeling. Experience in processing and analysis of neuroimaging data is desired but not required. Strong verbal and written communication skills. Ability to work independently and collaboratively within a team. Demonstrated first-author publication record or pre-print experience. Most importantly, a genuine interest in psychiatry, motivation to work in a team, and excitement for research. Prior work authorization required (no visa sponsorship available). We're excited to learn more about you! To apply for this position, please email your resume directly to Johanna Seitz at **********************. Please do not apply through this link. Additional Job Details (if applicable) Remote Type Hybrid Work Location 399 Revolution Drive EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The Massachusetts General Hospital Department of Emergency Medicine is seeking a highly quantitative, motivated, research-oriented postdoctoral scientist with strong data science and statistical modeling expertise. The ideal candidate will have advanced coding skills and a strong interest in translating quantitative methods to important problems in healthcare delivery and population health. This individual will contribute to quantitative modeling to address issues of access in emergency care delivery, with a focus on stroke care access and the prehospital setting. This individual will work under the general supervision of the Principal Investigator (PI) Dr. Zachrison and work collaboratively with Co-Investigators in the Columbia Healthcare Innovations Research and Evaluation Unit. This individual will be responsible for all aspects of data management and statistical analytic work for assigned projects. He/she will be a highly integrated team member interfacing with Investigators, Fellows, and other research staff on a regular basis. Qualifications Principle Duties and Responsibilities: Specific responsibilities include: Creating and maintaining a mathematical decision model. Using existing registry data to derive parameter estimates for incorporation into decision model. Working with Investigators on the development of the decision model and its use in related research questions. Drafting of Methods and Results sections for related manuscripts (with inclusion as co-author). Assist with grant applications (e.g., approach section) related to the decision model. Maintain IRB files and communication with IRB for the study. Responsible for overseeing all data-related amendments to the IRB. Collaborates with Principal Investigator (PI) and Co-Investigators in performance of above duties. Skills Required: Must have experience with: Data science or health services research and electronic data management systems. MS Office products. A specific statistical package (e.g., Python, R or equivalent) Must have: Doctoral degree (PhD) in quantitative field (data science, statistics, bioinformatics, applied math, or related discipline) Proficiency in programming and data science tools (Python, R, or equivalent) Strong statistical and machine learning background, with ability to develop and evaluate prediction models Excellent critical thinking and written and verbal communication skills. Excellent written and verbal communication skills. The ability to work well with a diverse group of individuals. Preferred: Prior experience with scientific publication (e.g., drafting manuscripts, conducting analyses, describing methods and results, etc.). Education: Field of Study/Additional Specialized Training: Doctoral degree in statistics, data science, mathematics, or a healthcare-related discipline. Must have a strong background in statistics programs (such as Python, R, STATA) and database management (such as MS Access and Excel). Experience: Preferred: Minimum of one year of data analysis experience is strongly preferred. Working Conditions: Normal indoor office environment. Additional Job Details (if applicable) Remote Type Hybrid Work Location 55 Fruit Street EEO Statement: 1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: Mass General Brigham Incorporated Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary The Research Compliance Associate is responsible for contributing to the overall success of the research compliance program at Mass General Brigham (MGB) as demonstrated by assisting with the development, oversight, and monitoring of research compliance functions through interpretation of MGB policy and local, state, and federal laws and regulations. The Research Compliance Associate should have a background in multiple research areas including, but not limited to, bench and laboratory research, animal research, human subjects research, international research activities, responsible conduct of research (RCR), research misconduct, research privacy, grants management, and controlled substances. The Research Compliance Associate will work under the direction of the Chief Research Compliance Officer and in collaboration with other departments within the research infrastructure. Qualifications Under the guidance of the Chief Research Compliance Officer, the Research Compliance Associate will have the following responsibilities: * Assist with the development of an annual work plan based on risk assessment. * Utilize metrics to measure program effectiveness. * Assist with internal investigations and operational audits to assess risk of research related issues, identify potential research compliance vulnerabilities, and make recommendations to improve internal controls. * Assist with education of the research community on research related topics to achieve compliance utilizing communication styles such as PowerPoint presentations, articles, website development, in-person training sessions, handouts, and infographics. * Stay abreast of requirements and changes in the regulatory environment and assist with interpretation and distribution of emerging MGB policies as well as local, state, and federal laws and regulations as it relates to research compliance. * Assist with evaluation of issues of non-compliance to include investigation, oversight, follow up, and resolution. * Assist in the development and revision of written research policies, procedures, and guidelines. * Assist in maintaining the research compliance webpage with relevant and up-to-date information in collaboration with the web development staff. * Utilize tact and diplomacy to communicate, build rapport and foster strategic alliances within the research community. * May represent Research Compliance at committee meetings. * Contribute to MGB and the Office of Compliance initiatives to promote a positive work environment. * Perform other related duties and responsibility as required. Education * Bachelor's Degree required. * Graduate degree in a healthcare field or law is preferred; related healthcare or legal experience considered in substitution Licenses and Credentials * CHRC preferred Experience * 3 years experience in project management in a complex organization required. * 1-3 years experience in a research-related position, preferably in a research compliance role. Familiarity with current applicable local, state, and federal laws and regulations related to research activities. Knowledge, Skills and Abilities * Proficient in using computer software applications such as Microsoft Excel, Word, PowerPoint, and Adobe. People Soft experience strongly preferred. * Strong interpersonal and communication skills (oral and written), including public speaking to facilitate training sessions, and lead discussion groups. * Ability to understand complex organizations; demonstrated political savvy. * Strong project management skills * Ability to work independently, with all levels, and within a strong team environment. * Ability to manage multiple responsibilities, often under time pressures. * Ability to function independently and effectively. Working Schedule * Hybrid, depending on business needs. On average, onsite required 2 days per week. Additional Job Details (if applicable) Remote Type Hybrid Work Location 399 Revolution Drive Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range * / Grade 6 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: Mass General Brigham Incorporated is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Courtesy posting Job Summary Summary Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. Does this position require Patient Care? No Essential Functions * Establishes and conducts active, complex scientific research as an independent researcher. * Makes strong intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter expert in field. * Contributes to the design and execution of experiments and/or research projects. * Exercises judgment in selecting methods and technologies to obtain results. * May collaborate with external researchers and/or receive external project funding support. * Presents results and prepares publications. * May assist PI in the training and supervision of other staff. Qualifications Education Doctorate Science required or Doctor of Medicine required Can this role accept experience in lieu of a degree? No Licenses and Credentials Experience High level of research experience in related field or area of expertise 5-7 years required Knowledge, Skills and Abilities * Excellent research skills. * Demonstrated broad knowledge of field. * Demonstrated evidence of specific scientific competence in field. * Evidence of potential for scientific creativity and original thought. * Able to exercise independent judgment and leadership. * Ability to contribute to publications. * Applicants should have recent, direct, hands-on experience in molecular biology and/or protein chemistry. Applicants must be proficient in using core biochemical techniques (Western Blot, ELISA, protein purification, immunohistochemistry, etc.). Experience in antibody development and characterization is advantageous but not required. Please direct resumes to Dr. Jasmeer Chhatwal at ********************************. Additional Job Details (if applicable) Remote Type Onsite Work Location 60 Fenwood Road EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary A research laboratory within the Brigham and Women's Hospital Division of Cardiovascular Medicine is seeking a highly motivated Research Scientist to join a growing, interdisciplinary team. The lab uses both in vitro (human ESC/iPSC) and in vivo (zebrafish) systems to model cardiovascular disorders and integrates transcriptional, (epi)genetic, metabolic, and phenotypic profiling at whole-organism, tissue, and single-cell levels. Our goal is to define the earliest molecular events driving disease onset, characterize their dynamic changes over time, and identify novel biomarkers and therapeutic targets. The Research Scientist will lead and directly perform automated, high-throughput microscopy screens to identify small-molecule compounds with improved efficacy over current clinical therapies. The role will involve hands-on execution of complex imaging workflows and the application of machine-learning approaches to large-scale imaging and phenotyping datasets. In addition, the Research Scientist will serve as the primary scientific point person for multiple industry collaborations, coordinating experimental design, execution, data generation, and communication between external partners and the lab. The Research Scientist will independently drive scientific projects, determine research direction in collaboration with the PI, and serve as an internal expert in automated imaging and computational analysis. The successful candidate will generate high-quality data, contribute substantially to scientific publications, mentor junior staff, engage with collaborators, and may participate in the development of external funding applications. Qualifications GENERAL SUMMARY/ OVERVIEW STATEMENT: A research laboratory within the Brigham and Women's Hospital Division of Cardiovascular Medicine is seeking a highly motivated Research Scientist to join a growing, interdisciplinary team. The lab uses both in vitro (human ESC/iPSC) and in vivo (zebrafish) systems to model cardiovascular disorders and integrates transcriptional, (epi)genetic, metabolic, and phenotypic profiling at whole-organism, tissue, and single-cell levels. Our goal is to define the earliest molecular events driving disease onset, characterize their dynamic changes over time, and identify novel biomarkers and therapeutic targets. The Research Scientist will lead and directly perform automated, high-throughput microscopy screens to identify small-molecule compounds with improved efficacy over current clinical therapies. The role will involve hands-on execution of complex imaging workflows and the application of machine-learning approaches to large-scale imaging and phenotyping datasets. In addition, the Research Scientist will serve as the primary scientific point person for multiple industry collaborations, coordinating experimental design, execution, data generation, and communication between external partners and the lab. The Research Scientist will independently drive scientific projects, determine research direction in collaboration with the PI, and serve as an internal expert in automated imaging and computational analysis. The successful candidate will generate high-quality data, contribute substantially to scientific publications, mentor junior staff, engage with collaborators, and may participate in the development of external funding applications. PRINCIPAL DUTIES AND RESPONSIBILITIES: * Provide overall scientific leadership and project management for assigned research initiatives, including direct execution of experimental work. * Design, optimize, and perform high-throughput automated imaging and screening assays, including day-to-day hands-on operation of imaging platforms and related instruments. * Conduct complex and innovative experiments using in vitro (human ESC/iPSC) and in vivo (zebrafish) models; troubleshoot technical challenges and refine protocols as needed. * Serve as a subject-matter expert while actively generating data, maintaining experimental quality, and ensuring reproducibility. * Exercise professional judgment in selecting experimental strategies, technologies, and analytical methods to obtain high-quality results. * Make project-level decisions to address and resolve critical scientific or technical challenges. * Regularly present results to the PI and contribute to preparation of manuscripts, reports, and presentations. * Collaborate with external partners as the scientific point person for industry-funded projects, ensuring high-quality and timely experimental deliverables. * Maintain an active publication record as senior author or substantial contributor, demonstrating scientific independence. * Participate in relevant scientific societies, committees, and professional activities. * Train and mentor junior research staff in laboratory techniques, data analysis approaches, and best practices in research execution. * Contribute to long-term strategic planning for the laboratory's research direction, technologies, and collaborative projects. QUALIFICATIONS: * PhD in molecular biology, molecular genetics, or a closely related field strongly preferred; an MS with substantial additional experience may be considered. * Prior experience with zebrafish research is required. * Minimum of 5 years of relevant research experience, including demonstrated independence. SKILLS/ ABILITIES/ COMPETENCIES REQUIRED: * Strong expertise and technical proficiency in molecular biology, cell biology, and genetics. * Demonstrated experience using model organisms (preferably zebrafish) for high-throughput drug or modifier screens. * Proven ability to design, execute, and troubleshoot complex research projects. * Ability to define project objectives, develop experimental approaches, and interpret results. * Strong scientific writing skills with a record of impactful contributions to peer-reviewed publications. * Excellent organizational, communication, and leadership skills. * Ability to work both independently and collaboratively within a multidisciplinary research team. WORKING CONDITIONS: Wet-lab/office setting. SUPERVISORY RESPONSIBILITY: May be responsible for managing junior staff or research assistants. Additional Job Details (if applicable) Remote Type Onsite Work Location 221 Longwood Avenue Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Site: The McLean Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary In consultation with their Principal Investigator (PI), undertake and execute a program of scientific study culminating in publication. Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. They assist their PI in the training and supervision of other laboratory personnel and in a wide variety of administrative tasks, as necessary. Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field. Contributes to the design and execution of experiments and/or research projects. Exercises judgment in selecting methods and technologies to obtain results. May collaborate with external researchers and/or receive external project funding support. Presents results and prepares publications. May assist PI in the training and supervision of other staff. Performs other duties as assigned Complies with all policies and standards Qualifications Education Degree Field of Study Required/Preferred And/Or Doctorate Related Field of Study required Can this role accept experience in lieu of Education requirements? No Work Experience Experience Details/Years of Experience Required/Preferred And/Or Previous Research experience (inclusive of graduate and postdoctoral experience) 5-7 years required Knowledge, Skills and Abilities Excellent research skills. Demonstrated evidence of specific scientific competence in field. Demonstrated broad knowledge of field. Evidence of potential for scientific creativity and original though. Able to exercise independent judgment and leadership. Ability to contribute to publications. Physical Requirements Category: Healthcare & Safety Physical Requirements The physical requirements described here generally represent those that must be met by an employee to successfully perform the essential functions of this job. These duties may not be representative of all positions within this job description and may vary from time to time based on the role and/or operational needs. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions. Additional Job Details (if applicable) Physical Requirements Standing Frequently (34-66%) Walking Frequently (34-66%) Sitting Occasionally (3-33%) Lifting Frequently (34-66%) 35lbs+ (w/assisted device) Carrying Frequently (34-66%) 20lbs - 35lbs Pushing Occasionally (3-33%) Pulling Occasionally (3-33%) Climbing Rarely (Less than 2%) Balancing Frequently (34-66%) Stooping Occasionally (3-33%) Kneeling Occasionally (3-33%) Crouching Occasionally (3-33%) Crawling Rarely (Less than 2%) Reaching Frequently (34-66%) Gross Manipulation (Handling) Frequently (34-66%) Fine Manipulation (Fingering) Frequently (34-66%) Feeling Constantly (67-100%) Foot Use Rarely (Less than 2%) Vision - Far Constantly (67-100%) Vision - Near Constantly (67-100%) Talking Constantly (67-100%) Hearing Constantly (67-100%) Remote Type Onsite Work Location 115 Mill Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: 1600 The McLean Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at **************. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.