Principal Research Scientist jobs at Genentech - 224 jobs

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech. The Opportunity We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team. This is a technical leadership position within our Peptide Therapeutics department, focused on advancing Peptide Therapeutics. The ideal candidate will be a significant contributor and a proven leader, responsible for optimizing and advancing novel peptide therapeutics into clinical development. You will lead the Medicinal Chemistry efforts for a highly integrated and collaborative team, applying your deep scientific expertise to solve complex drug discovery challenges and drive projects forward. Key Responsibilities * Drive the discovery of novel peptide therapeutics. Govern the design and synthesis of innovative peptides and peptidomimetics with enhanced potency, stability, and pharmacokinetic properties. * Lead scientific and project teams from concept to clinic. Initiate and lead new research projects, guiding them from early hit identification through lead optimization, with the ultimate goal of advancing promising compounds to clinical development. * Implement rational drug design strategies. Apply a broad repertoire of skills, including peptide synthesis, conformational analysis, and computational methods to implement strategic structure-activity relationship plans that optimize the pharmaceutical properties of peptide leads. * Champion cross-functional collaboration. Lead or co-lead multidisciplinary teams, serving as a key scientific partner to colleagues in Research Biology and Drug Discovery to overcome complex challenges associated with the development of peptide therapeutics. * Provide scientific leadership and mentorship. Supervise and mentor junior scientists, contribute to the prioritization of team objectives, and propose future strategies to meet broader portfolio goals. * Ensure data integrity and project success. Oversee the analysis and interpretation of complex analytical data, including mass spectrometry, HPLC, and NMR, to confirm compound identity and purity. You will be responsible for managing multiple projects simultaneously, delivering high-quality results on time. Who You Are * Education: Ph.D. or postdoctoral degree in Organic Chemistry, Medicinal Chemistry, or a related field. * Experience: A minimum of 7 years of experience in the biotechnology or pharmaceutical industry, with a proven track record of advancing drug candidates from the conceptual stage into clinical testing. Technical Expertise: * Demonstrated mastery in complex molecule organic synthesis, including proficiency in both automated solid-phase peptide synthesis, and solution-phase small molecule synthesis, utilizing state-of-the-art protecting group and purification strategies. * Must possess expertise in high-throughput and parallel synthesis for library generation, coupled with the expert ability to analyze and interpret all relevant analytical data (HPLC, Mass Spectrometry, NMR) to confirm the identity and purity of all synthesized drug candidates. * Required experience in designing, developing, and implementing novel synthetic routes to overcome challenging chemical and physicochemical issues associated with optimizing both peptide and small molecule scaffolds. * Must possess deep experience in the design and multi-step synthesis of novel, non-commercial building blocks and scaffolds to enable SAR exploration and overcome property liabilities. * Deep knowledge of macrocyclic peptides, including the properties required for different routes of administration (i.e. IV vs SC vs PO, etc), and related library-based screening technologies (e.g., OBOC, mRNA display, AS/MS). Computational Methods: * Experience with computational modeling and simulation for peptide design and optimization, including conformational sampling and molecular dynamics (MD) simulations. * Proficiency in structure-based drug design and ligand-based drug design to guide peptide modifications. * Familiarity with machine learning and AI-driven platforms for predicting peptide properties, optimizing sequences, and generating novel scaffolds. * Experience using common computational chemistry software (e.g., Schrödinger, MOE, Maestro, or similar). Leadership & Collaboration: * Demonstrated success in a leadership role, guiding multidisciplinary teams to deliver drug candidates. * Exceptional communication and presentation skills, with the ability to inspire and lead within a globally matrixed organization. * A highly collaborative and transparent style, with a proven ability to mentor junior scientists and build strong relationships across all levels of the organization. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $168,600 to $313,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits #LI-KC2 Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

As a Product Marketing Applications Scientist you will contribute to the development of Bioconsumable workflows designed to enhance HPLC and LC/MS biopharmaceutical sample preparation, method development and data analysis to enable analysis of glycans and other CQAs within peptide, oligonucleotide and protein (mAb) therapeutics. You will also ensure the success of new products by generating product proof-points, competitive comparison data, and workflow method. The Product Marketing Applications Scientist is a member of the Biopharma product marketing team that develops new products and workflow methodologies, brings them to market, and publishes application notes using these workflows. You'll design and execute experiments required to create reproducible and robust workflows, application notes, whitepapers and posters required for customers to rapidly adopt these workflows in therapeutic development and QA/QC manufacturing release. You will also serve as a technical expert. These duties will include but are not limited to customer presentations, troubleshooting assistance, and field support. We foster a collaborative and informal team culture built on trust, respect, and clear accountability. Our work pace is fast, driven by a shared passion for delivering outstanding biopharma solutions. Together, we strive for excellence when serving our customers and make sure we develop professionally while delivering business success. Key Responsibilities: She/he will be a member of the Biopharma product marketing team that develops new products and workflow methodologies, brings them to market, and publishes application notes using these workflows. Design and execute experiments required to create reproducible and robust workflows, application notes, whitepapers and posters required for customers to rapidly adopt these workflows in therapeutic development and QA/QC manufacturing release. Serve as a technical expert. These duties will include but are not limited to customer presentations, troubleshooting assistance, and field support. You'll Work Closely With Product Management across the Biopharma Marketing team and more broadly across Agilent. R&D in the development and testing of new products and technologies. Manufacturing as a resource for testing process improvements and consulting on technical issues. The Commercial team in their support of customer technical questions. Qualifications 4+ years of experience with Biopharmaceutical CQA or purification analysis. Ph. D degree in the field of chemistry, analytical chemistry, biochemistry or related fields. Prior biopharmaceutical industry experience a plus. Strong background in assay development including knowledge of glycans and proteins as well as peptide, oligonucleotide and protein therapeutic CQA and purification analysis. Experience with HPLC, LC/MS instrumentation, Fluorescence detection, software and sample preparation. Knowledge of biopharmaceutical therapeutics development and characterization trends. Experience with Glycan Analysis and Protein conjugation. Ability to work independently and be self-motivated but also collaborative, contributes to the success of multidiscipline teams. Experience and comfort with technical writing and presentations. Possess strong communication skills and be willing to travel to present at conferences and at customer sites. Additional Details This job has a full time weekly schedule. Applications for this job will be accepted until at least December 24, 2025 or until the job is no longer posted.The full-time equivalent pay range for this position is $107,440.00 - $179,626.00/yr plus eligibility for bonus, stock and benefits. Our pay ranges are determined by role, level, and location. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, a recruiter can share more about the specific pay range for a preferred location. Pay and benefit information by country are available at: ************************************* Agilent Technologies, Inc. is an Equal Employment Opportunity and merit-based employer that values individuals of all backgrounds at all levels. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to sex, pregnancy, race, religion or religious creed, color, gender, gender identity, gender expression, national origin, ancestry, physical or mental disability, medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military or veteran status, protected veteran status, or any other basis protected by federal, state, local law, ordinance, or regulation and will not be discriminated against on these bases. Agilent Technologies, Inc., is committed to creating and maintaining an inclusive in the workplace where everyone is welcome, and strives to support candidates with disabilities. If you have a disability and need assistance with any part of the application or interview process or have questions about workplace accessibility, please email job_******************* or contact ***************. For more information about equal employment opportunity protections, please visit *************************************** Required: 10% of the TimeShift: DayDuration: No End DateJob Function: Marketing

As a Product Marketing Applications Scientist you will contribute to the development of Bioconsumable workflows designed to enhance HPLC and LC/MS biopharmaceutical sample preparation, method development and data analysis to enable analysis of glycans and other CQAs within peptide, oligonucleotide and protein (mAb) therapeutics. You will also ensure the success of new products by generating product proof-points, competitive comparison data, and workflow method. The Product Marketing Applications Scientist is a member of the Biopharma product marketing team that develops new products and workflow methodologies, brings them to market, and publishes application notes using these workflows. You'll design and execute experiments required to create reproducible and robust workflows, application notes, whitepapers and posters required for customers to rapidly adopt these workflows in therapeutic development and QA/QC manufacturing release. You will also serve as a technical expert. These duties will include but are not limited to customer presentations, troubleshooting assistance, and field support. We foster a collaborative and informal team culture built on trust, respect, and clear accountability. Our work pace is fast, driven by a shared passion for delivering outstanding biopharma solutions. Together, we strive for excellence when serving our customers and make sure we develop professionally while delivering business success. Key Responsibilities: * She/he will be a member of the Biopharma product marketing team that develops new products and workflow methodologies, brings them to market, and publishes application notes using these workflows. * Design and execute experiments required to create reproducible and robust workflows, application notes, whitepapers and posters required for customers to rapidly adopt these workflows in therapeutic development and QA/QC manufacturing release. * Serve as a technical expert. These duties will include but are not limited to customer presentations, troubleshooting assistance, and field support. You'll Work Closely With * Product Management across the Biopharma Marketing team and more broadly across Agilent. * R&D in the development and testing of new products and technologies. * Manufacturing as a resource for testing process improvements and consulting on technical issues. * The Commercial team in their support of customer technical questions. Qualifications * 4+ years of experience with Biopharmaceutical CQA or purification analysis. * Ph. D degree in the field of chemistry, analytical chemistry, biochemistry or related fields. * Prior biopharmaceutical industry experience a plus. * Strong background in assay development including knowledge of glycans and proteins as well as peptide, oligonucleotide and protein therapeutic CQA and purification analysis. * Experience with HPLC, LC/MS instrumentation, Fluorescence detection, software and sample preparation. * Knowledge of biopharmaceutical therapeutics development and characterization trends. * Experience with Glycan Analysis and Protein conjugation. * Ability to work independently and be self-motivated but also collaborative, contributes to the success of multidiscipline teams. * Experience and comfort with technical writing and presentations. * Possess strong communication skills and be willing to travel to present at conferences and at customer sites. Additional Details This job has a full time weekly schedule. Applications for this job will be accepted until at least December 24, 2025 or until the job is no longer posted. The full-time equivalent pay range for this position is $107,440.00 - $179,626.00/yr plus eligibility for bonus, stock and benefits. Our pay ranges are determined by role, level, and location. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, a recruiter can share more about the specific pay range for a preferred location. Pay and benefit information by country are available at: ************************************* Agilent Technologies, Inc. is an Equal Employment Opportunity and merit-based employer that values individuals of all backgrounds at all levels. All individuals, regardless of personal characteristics, are encouraged to apply. All qualified applicants will receive consideration for employment without regard to sex, pregnancy, race, religion or religious creed, color, gender, gender identity, gender expression, national origin, ancestry, physical or mental disability, medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military or veteran status, protected veteran status, or any other basis protected by federal, state, local law, ordinance, or regulation and will not be discriminated against on these bases. Agilent Technologies, Inc., is committed to creating and maintaining an inclusive in the workplace where everyone is welcome, and strives to support candidates with disabilities. If you have a disability and need assistance with any part of the application or interview process or have questions about workplace accessibility, please email job_******************* or contact ***************. For more information about equal employment opportunity protections, please visit ********************************* Travel Required: 10% of the Time Shift: Day Duration: No End Date Job Function: Marketing

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech, a member of the Roche Group. The Opportunity The Head of Translational Safety (TS) Digital Pathology Analytics provides the strategic vision, scientific and technical direction, and operational leadership for the Translational Safety Digital Pathology group. The successful Sr Principal Sci-Pathologist candidate will lead efforts focused on driving applications for digital pathology in the field of toxicologic pathology and predictive nonclinical safety evaluation, thereby contributing to the efficient, comprehensive, and integrated safety profiling of Genentech drug candidates from the Research stage through marketed products. This includes managing a team of AI/ML scientists to create and implement novel, state-of-the-art analytical and computational approaches aimed at improving the efficiency of pathology workflows and enhancing the acquisition and interpretation of high-quality quantitative morphologic data obtained from in vivo studies and in vitro methodologies. This position is also responsible for engaging and directing cross-functional digital pathology collaborations throughout the Genentech/Roche organization. In this role, you will: Manage strategy and team to advance digital pathology efforts to achieve TS, gRED, and Roche-wide cross-functional goals Collaborate with project pathologists and toxicologists to align digital pathology goals with the evolving therapeutic portfolio Represent TS as a primary gRED digital pathology contact for fostering collaboration and coordination on decisions with global organization-wide impact and significance Influence the informatics and computational strategies across the global Roche organization and drive highly impactful initiatives internally and externally Budget and resource planning responsibility (horizon of ~1 year), including the evaluation and application of emerging technologies (hardware and software) Manage 5-10 FTEs or contractors Who you are D.V.M. and Ph.D. or equivalent curriculum. Diplomate in either the American or European College of Veterinary Pathology Expertise in the application of digital pathology, image analysis, machine learning, and/or computer vision to pathology and biology 10+ years of relevant drug development experience and at least 4 years of management experience Demonstrated outstanding leadership and effective management in scientific, technical, and/or operational areas, with the ability to lead toward organizational goals across functions Strong reputation as a manager and mentor Sustained record of impactful performance, strategic insight in advancing drug development This role will be based in South San Francisco, and relocation benefits are available The expected salary range for this position, based on the primary location of California, is $198,900 - $369,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech. The Opportunity We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team. This is a technical leadership position within our Peptide Therapeutics department, focused on advancing Peptide Therapeutics. The ideal candidate will be a significant contributor and a proven leader, responsible for optimizing and advancing novel peptide therapeutics into clinical development. You will lead the Medicinal Chemistry efforts for a highly integrated and collaborative team, applying your deep scientific expertise to solve complex drug discovery challenges and drive projects forward. Key Responsibilities Drive the discovery of novel peptide therapeutics. Govern the design and synthesis of innovative peptides and peptidomimetics with enhanced potency, stability, and pharmacokinetic properties. Lead scientific and project teams from concept to clinic. Initiate and lead new research projects, guiding them from early hit identification through lead optimization, with the ultimate goal of advancing promising compounds to clinical development. Implement rational drug design strategies. Apply a broad repertoire of skills, including peptide synthesis, conformational analysis, and computational methods to implement strategic structure-activity relationship plans that optimize the pharmaceutical properties of peptide leads. Champion cross-functional collaboration. Lead or co-lead multidisciplinary teams, serving as a key scientific partner to colleagues in Research Biology and Drug Discovery to overcome complex challenges associated with the development of peptide therapeutics. Provide scientific leadership and mentorship. Supervise and mentor junior scientists, contribute to the prioritization of team objectives, and propose future strategies to meet broader portfolio goals. Ensure data integrity and project success. Oversee the analysis and interpretation of complex analytical data, including mass spectrometry, HPLC, and NMR, to confirm compound identity and purity. You will be responsible for managing multiple projects simultaneously, delivering high-quality results on time. Who You Are Education: Ph.D. or postdoctoral degree in Organic Chemistry, Medicinal Chemistry, or a related field. Experience: A minimum of 7 years of experience in the biotechnology or pharmaceutical industry, with a proven track record of advancing drug candidates from the conceptual stage into clinical testing. Technical Expertise: Demonstrated mastery in complex molecule organic synthesis, including proficiency in both automated solid-phase peptide synthesis, and solution-phase small molecule synthesis, utilizing state-of-the-art protecting group and purification strategies. Must possess expertise in high-throughput and parallel synthesis for library generation, coupled with the expert ability to analyze and interpret all relevant analytical data (HPLC, Mass Spectrometry, NMR) to confirm the identity and purity of all synthesized drug candidates. Required experience in designing, developing, and implementing novel synthetic routes to overcome challenging chemical and physicochemical issues associated with optimizing both peptide and small molecule scaffolds. Must possess deep experience in the design and multi-step synthesis of novel, non-commercial building blocks and scaffolds to enable SAR exploration and overcome property liabilities. Deep knowledge of macrocyclic peptides, including the properties required for different routes of administration (i.e. IV vs SC vs PO, etc), and related library-based screening technologies (e.g., OBOC, mRNA display, AS/MS). Computational Methods: Experience with computational modeling and simulation for peptide design and optimization, including conformational sampling and molecular dynamics (MD) simulations. Proficiency in structure-based drug design and ligand-based drug design to guide peptide modifications. Familiarity with machine learning and AI-driven platforms for predicting peptide properties, optimizing sequences, and generating novel scaffolds. Experience using common computational chemistry software (e.g., Schrödinger, MOE, Maestro, or similar). Leadership & Collaboration: Demonstrated success in a leadership role, guiding multidisciplinary teams to deliver drug candidates. Exceptional communication and presentation skills, with the ability to inspire and lead within a globally matrixed organization. A highly collaborative and transparent style, with a proven ability to mentor junior scientists and build strong relationships across all levels of the organization. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $168,600 to $313,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits #LI-KC2 Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers. We set and achieve bold ambitions in our fight against the world's most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come. As a Senior Associate Scientist you will design, execute, analyze, and communicate rigorous experiments to identify, understand and target tumor cell dependencies. Partnering with our interdisciplinary colleagues throughout the Research Division will be essential, in the service of advancing novel medicines that impact patients' lives. Scientific and Technical Skills Think critically and creatively to design, execute, analyze, and communicate rigorous experimentation, performed with minimal input from senior colleagues. Understand the relevant scientific and technical concepts to accelerate discovery activities and develop novel targeting modalities. Demonstrate top-quality technical capabilities to deliver well-controlled experimental results that inform decisions on project teams. Ability and curiosity to learn, develop and execute new and more complex technologies, concepts, and experiments from other colleagues and literature with minimal guidance. Complete large volumes of experimental work in a timely manner, proactively communicating and revising priorities with senior colleagues and team members. Coach less experienced colleagues in new concepts and technologies. Knowledge, Experience and Skills Masters with 3+ years of experience or Bachelor's with 5+ years of experience. Hands-on experience with tumor biology, drug discovery, target identification and technology development. Experience with bioinformatic tools and analyses a plus. Track record of collaboratively driving research to productive, creative, data-driven decisions, demonstrating a team-centric mindset, communication acumen, and excellent interpersonal skills. The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. For jobs in the United States: Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. For Current Gilead Employees and Contractors: Please apply via the Internal Career Opportunities portal in Workday.

At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers. We set and achieve bold ambitions in our fight against the world's most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come. As a Senior Associate Scientist you will design, execute, analyze, and communicate rigorous experiments to identify, understand and target tumor cell dependencies. Partnering with our interdisciplinary colleagues throughout the Research Division will be essential, in the service of advancing novel medicines that impact patients' lives. Scientific and Technical Skills * Think critically and creatively to design, execute, analyze, and communicate rigorous experimentation, performed with minimal input from senior colleagues. * Understand the relevant scientific and technical concepts to accelerate discovery activities and develop novel targeting modalities. * Demonstrate top-quality technical capabilities to deliver well-controlled experimental results that inform decisions on project teams. * Ability and curiosity to learn, develop and execute new and more complex technologies, concepts, and experiments from other colleagues and literature with minimal guidance. * Complete large volumes of experimental work in a timely manner, proactively communicating and revising priorities with senior colleagues and team members. * Coach less experienced colleagues in new concepts and technologies. Knowledge, Experience and Skills * Masters with 3+ years of experience or Bachelor's with 5+ years of experience. * Hands-on experience with tumor biology, drug discovery, target identification and technology development. * Experience with bioinformatic tools and analyses a plus. * Track record of collaboratively driving research to productive, creative, data-driven decisions, demonstrating a team-centric mindset, communication acumen, and excellent interpersonal skills. The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. For jobs in the United States: Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. For Current Gilead Employees and Contractors: Please apply via the Internal Career Opportunities portal in Workday.

At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. **Job Description** At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers. We set and achieve bold ambitions in our fight against the world's most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come. As a Senior Associate Scientist you will design, execute, analyze, and communicate rigorous experiments to identify, understand and target tumor cell dependencies. Partnering with our interdisciplinary colleagues throughout the Research Division will be essential, in the service of advancing novel medicines that impact patients' lives. **Scientific and Technical Skills** + Think critically and creatively to design, execute, analyze, and communicate rigorous experimentation, performed with minimal input from senior colleagues. + Understand the relevant scientific and technical concepts to accelerate discovery activities and develop novel targeting modalities. + Demonstrate top-quality technical capabilities to deliver well-controlled experimental results that inform decisions on project teams. + Ability and curiosity to learn, develop and execute new and more complex technologies, concepts, and experiments from other colleagues and literature with minimal guidance. + Complete large volumes of experimental work in a timely manner, proactively communicating and revising priorities with senior colleagues and team members. + Coach less experienced colleagues in new concepts and technologies. **Knowledge, Experience and Skills** + Masters with 3+ years of experience or Bachelor's with 5+ years of experience. + Hands-on experience with tumor biology, drug discovery, target identification and technology development. + Experience with bioinformatic tools and analyses a plus. + Track record of collaboratively driving research to productive, creative, data-driven decisions, demonstrating a team-centric mindset, communication acumen, and excellent interpersonal skills. The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. **For jobs in the United States:** Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' (********************************************** poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT (********************************************************* YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. **For Current Gilead Employees and Contractors:** Please apply via the Internal Career Opportunities portal in Workday. Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.

Additional Information All your information will be kept confidential according to EEO guidelines.

As part of Pharma Technical Development (PTD) our organization is committed to deliver the Pharma ambitions by bringing game-changing therapies from clinical phase I into the market to serve every patient, every day. Our core business is to develop safe, innovative and effective drugs using cutting edge technologies for manufacturing process (Drug Substance and Drug Product), clinical supply, formulation, device, packaging, and analytical development. Together with our partners, Global Biologics Bioprocess Development develops robust, efficient, and sustainable bioprocesses including Cell Line & Media Development, Cell Culture & Fermentation, and Purification Development. The Cell Culture Development US organization provides innovative technologies and strategic support for development and commercialization of Genentech and Roche's biologic portfolio, including standard monoclonal antibodies as well as complex and modified proteins such as antibody drug conjugates and bispecific antibodies. The Roche/Genentech biological portfolio spans late stage research (LSR), preclinical, clinical, and initial marketing authorization. The department of Cell Culture and Bioprocess Operations (CCBO) within Genentech's Pharma Technical Development (PTD) organization is seeking a highly experienced and self-motivated senior-level scientist to lead cell culture media development efforts for a diverse range of biological products. The ideal candidate for this role will have extensive cell culture media development experience and demonstrated strengths in fostering teamwork and collaboration with an inclusive mindset. The Opportunity The successful candidate will lead media development for mammalian cell lines expressing therapeutic antibodies, bispecific antibodies, complex biologics and other new modalities including gene and cell therapies. The successful candidate will provide scientific and strategic guidance to establish highly-productive next-generation platform processes in collaboration with multiple stakeholders within and outside CCBO/PTD. This position requires a passion for scientific rigor and excellent skills in leadership, communication, strategic thinking, decision making, influencing, and problem solving. The location for this role is our US Headquarters in South San Francisco, CA. Responsibilities * Develop chemically-defined cell culture media to meet different needs, including high-density cultures for biologics manufacturing, and cell-based therapies. * Innovate, define strategies, and apply advanced technologies to improve cell culture performance and establish next-generation platform processes. * Serve as primary in-house expert for state-of-the-art practice in media development. * Provide technical leadership and strategic guidance to support technical/product teams, media preparation operations, raw material assessments, and supply chain updates. * Guide, motivate, and develop staff in the Media and Process Group (MPG) within CCBO, with emphasis on defining their technical priorities and focus. * Cultivate a lean mindset with focus on simplification and continuous improvement. * Interface effectively within CCBO department and PTD, as well as with other internal Genentech/Roche organizations and external collaborators. * Anticipate, identify, and resolve issues, with escalation and stakeholder communication where appropriate. * Exert influence inside and outside the company through presentations, publications, and participation in meetings. Who you are The successful candidate will have an established track record for strong technical leadership in cell culture media development. Other requirements for this role include: * PhD (biological sciences, chemical engineering or related discipline) with 10+ years of relevant work experience OR BS/MS (biological sciences, chemical engineering or related discipline) with 14+ years of relevant work experience. * Solid understanding of cell metabolism and tools for metabolic pathway analyses. * Expertise in using computational methods, metabolic models, statistical design of experiments, -omics, and other current technologies to improve cell culture processes. * Prior experience in media development for mammalian cell cultures. * Prior experience in technology transfer and development of cell-based therapies is a plus. * Demonstrated ability to lead and drive technical projects to completion through scientific rigor and strong organization skills. * Proven track record of managing and developing highly productive technical teams with an inclusive mindset. * Proven track record of building and maintaining strong relationships with partners, customers, and collaborators. * Proven track record of excellent verbal and written communication through conference presentations and publications. This is an onsite position based out of South San Francisco, California, USA. Relocation benefits are available for this position. The expected salary range for this position based on the primary location of South San Francisco, CA is $180,700 to $335,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

As part of Pharma Technical Development (PTD) our organization is committed to deliver the Pharma ambitions by bringing game-changing therapies from clinical phase I into the market to serve every patient, every day. Our core business is to develop safe, innovative and effective drugs using cutting edge technologies for manufacturing process (Drug Substance and Drug Product), clinical supply, formulation, device, packaging, and analytical development. Together with our partners, Global Biologics Bioprocess Development develops robust, efficient, and sustainable bioprocesses including Cell Line & Media Development, Cell Culture & Fermentation, and Purification Development. The Cell Culture Development US organization provides innovative technologies and strategic support for development and commercialization of Genentech and Roche's biologic portfolio, including standard monoclonal antibodies as well as complex and modified proteins such as antibody drug conjugates and bispecific antibodies. The Roche/Genentech biological portfolio spans late stage research (LSR), preclinical, clinical, and initial marketing authorization. The department of Cell Culture and Bioprocess Operations (CCBO) within Genentech's Pharma Technical Development (PTD) organization is seeking a highly experienced and self-motivated senior-level scientist to lead cell culture media development efforts for a diverse range of biological products. The ideal candidate for this role will have extensive cell culture media development experience and demonstrated strengths in fostering teamwork and collaboration with an inclusive mindset. The Opportunity The successful candidate will lead media development for mammalian cell lines expressing therapeutic antibodies, bispecific antibodies, complex biologics and other new modalities including gene and cell therapies. The successful candidate will provide scientific and strategic guidance to establish highly-productive next-generation platform processes in collaboration with multiple stakeholders within and outside CCBO/PTD. This position requires a passion for scientific rigor and excellent skills in leadership, communication, strategic thinking, decision making, influencing, and problem solving. The location for this role is our US Headquarters in South San Francisco, CA. Responsibilities Develop chemically-defined cell culture media to meet different needs, including high-density cultures for biologics manufacturing, and cell-based therapies. Innovate, define strategies, and apply advanced technologies to improve cell culture performance and establish next-generation platform processes. Serve as primary in-house expert for state-of-the-art practice in media development. Provide technical leadership and strategic guidance to support technical/product teams, media preparation operations, raw material assessments, and supply chain updates. Guide, motivate, and develop staff in the Media and Process Group (MPG) within CCBO, with emphasis on defining their technical priorities and focus. Cultivate a lean mindset with focus on simplification and continuous improvement. Interface effectively within CCBO department and PTD, as well as with other internal Genentech/Roche organizations and external collaborators. Anticipate, identify, and resolve issues, with escalation and stakeholder communication where appropriate. Exert influence inside and outside the company through presentations, publications, and participation in meetings. Who you are The successful candidate will have an established track record for strong technical leadership in cell culture media development. Other requirements for this role include: PhD (biological sciences, chemical engineering or related discipline) with 10+ years of relevant work experience OR BS/MS (biological sciences, chemical engineering or related discipline) with 14+ years of relevant work experience. Solid understanding of cell metabolism and tools for metabolic pathway analyses. Expertise in using computational methods, metabolic models, statistical design of experiments, -omics, and other current technologies to improve cell culture processes. Prior experience in media development for mammalian cell cultures. Prior experience in technology transfer and development of cell-based therapies is a plus. Demonstrated ability to lead and drive technical projects to completion through scientific rigor and strong organization skills. Proven track record of managing and developing highly productive technical teams with an inclusive mindset. Proven track record of building and maintaining strong relationships with partners, customers, and collaborators. Proven track record of excellent verbal and written communication through conference presentations and publications. This is an onsite position based out of South San Francisco, California, USA. Relocation benefits are available for this position. The expected salary range for this position based on the primary location of South San Francisco, CA is $180,700 to $335,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

** As part of Pharma Technical Development (PTD) our organization is committed to deliver the Pharma ambitions by bringing game-changing therapies from clinical phase I into the market to serve every patient, every day. Our core business is to develop safe, innovative and effective drugs using cutting edge technologies for manufacturing process (Drug Substance and Drug Product), clinical supply, formulation, device, packaging, and analytical development. Together with our partners, Global Biologics Bioprocess Development develops robust, efficient, and sustainable bioprocesses including Cell Line & Media Development, Cell Culture & Fermentation, and Purification Development. The Cell Culture Development US organization provides innovative technologies and strategic support for development and commercialization of Genentech and Roche's biologic portfolio, including standard monoclonal antibodies as well as complex and modified proteins such as antibody drug conjugates and bispecific antibodies. The Roche/Genentech biological portfolio spans late stage research (LSR), preclinical, clinical, and initial marketing authorization. The department of Cell Culture and Bioprocess Operations (CCBO) within Genentech's Pharma Technical Development (PTD) organization is seeking a highly experienced and self-motivated senior-level scientist to lead cell culture media development efforts for a diverse range of biological products. **The ideal candidate for this role will have extensive cell culture media development experience** and demonstrated strengths in fostering teamwork and collaboration with an inclusive mindset. **The Opportunity** The successful candidate will lead media development for mammalian cell lines expressing therapeutic antibodies, bispecific antibodies, complex biologics and other new modalities including gene and cell therapies. The successful candidate will provide scientific and strategic guidance to establish highly-productive next-generation platform processes in collaboration with multiple stakeholders within and outside CCBO/PTD. This position requires a passion for scientific rigor and excellent skills in leadership, communication, strategic thinking, decision making, influencing, and problem solving. The location for this role is our US Headquarters in South San Francisco, CA. Responsibilities + Develop chemically-defined cell culture media to meet different needs, including high-density cultures for biologics manufacturing, and cell-based therapies. + Innovate, define strategies, and apply advanced technologies to improve cell culture performance and establish next-generation platform processes. + Serve as primary in-house expert for state-of-the-art practice in media development. + Provide technical leadership and strategic guidance to support technical/product teams, media preparation operations, raw material assessments, and supply chain updates. + Guide, motivate, and develop staff in the Media and Process Group (MPG) within CCBO, with emphasis on defining their technical priorities and focus. + Cultivate a lean mindset with focus on simplification and continuous improvement. + Interface effectively within CCBO department and PTD, as well as with other internal Genentech/Roche organizations and external collaborators. + Anticipate, identify, and resolve issues, with escalation and stakeholder communication where appropriate. + Exert influence inside and outside the company through presentations, publications, and participation in meetings. **Who you are** **The successful candidate will have an established track record for strong technical leadership in cell culture media development.** Other requirements for this role include: + PhD (biological sciences, chemical engineering or related discipline) with 10+ years of relevant work experience OR BS/MS (biological sciences, chemical engineering or related discipline) with 14+ years of relevant work experience. + Solid understanding of cell metabolism and tools for metabolic pathway analyses. + Expertise in using computational methods, metabolic models, statistical design of experiments, -omics, and other current technologies to improve cell culture processes. + Prior experience in media development for mammalian cell cultures. + Prior experience in technology transfer and development of cell-based therapies is a plus. + Demonstrated ability to lead and drive technical projects to completion through scientific rigor and strong organization skills. + Proven track record of managing and developing highly productive technical teams with an inclusive mindset. + Proven track record of building and maintaining strong relationships with partners, customers, and collaborators. + Proven track record of excellent verbal and written communication through conference presentations and publications. This is an onsite position based out of South San Francisco, California, USA. Relocation benefits are available for this position. The expected salary range for this position based on the primary location of South San Francisco, CA is $180,700 to $335,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits (**************************************************** Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .

Description Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. We are seeking a motivated Scientist with experience in genetic metabolic diseases to join our team. The Scientist will join the Enzymatic and Metabolic In Vivo team to design and execute key in vivo studies focused on developing therapeutics to transform the lives of people with genetic metabolic disorders. This role reports into the In Vivo Lead. The primary role of the Scientist will be in design and execution of in vivo studies as part of the Enzymatic and Metabolic In Vivo Team. They will work collaboratively across the Research and Early Development Department to identify, develop and execute project strategies for in vivo testing of novel therapeutics. Areas of focus will span from animal model development to testing novel therapeutic approaches for genetic metabolic disorders. The successful candidate will have a strong background in metabolic and enzymatic biology, with demonstrated experience in the use of model systems in research. Experience with in vivo models of disease and a collaborative mindset is critical. While some industry experience is a plus, it is not required. The successful candidate will contribute in vivo model evaluation and support to project teams that support the project goals. Including in vivo study design, hands on in vivo study performance, selection and characterization of animal models, as well as application of in vivo methods and techniques. Strong written communication skills are critical for FDA filings, writing IACUC protocols, communicating scientific strategy, monitoring in vivo studies and collaborating with CRO's, tissue collection, and sample management. The successful candidate will also have experience with in vivo technical tasks including but not limited to dosing techniques (SC, IP, IV, RO, PO), blood collection (tail nick, saphenous vein puncture), and IVIS imaging. The ideal candidate will have Postdoctoral Academic or Biotech/Pharma industry in vivo experience in the metabolic disease field. The ideal candidate will have hands-on experience with animal models of metabolic/enzymatic disease, a proven track record of high-quality science. Proficiency with in vivo methods such as administration of test articles, perfusion and tissue collection, blood collection, as well as rodent surgical models is required. Candidate level at hire will depend on education and experience.Responsibilities: Research Support Conduct research on genetic metabolic diseases Contribute to novel therapeutic programs based on innovative, ground-breaking discoveries that could lead to new, high-impact opportunities for patients Perform research and publish findings in high-impact journals and present research at major conferences Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums Write, review and contribute to study synopses, protocols, study reports and regulatory documents Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects Participate in multi-disciplinary drug development teams and may lead sub-teams Excellent written and verbal communication Ability to build/foster productive cross-functional collaborations both within and external to BioMarin Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice or rats, including health checks and documentation, will also be required. Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status including adverse study events. Meticulous electronic lab notebook documentation. Communicate experimental plans and results to the project team. Support product development and regulatory filings for pivotal clinical studies. Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines. Share your knowledge and understanding with other team members Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs. Other duties as assigned. Willingness to work on site full time including off hours and weekends based on study needs. Other duties as assigned. General requirements for the position: Demonstrated experience in metabolic biology/disease research in academia or industry (preferred) including publication record Strong analytical, problem-solving, and decision-making skills Strong understanding of genetically engineered models, breeding, and management and Gene therapy modalities Excellent oral and written communication skills Passion for contributing your scientific skills to develop therapies for patients in need Must be able to utilize computer databases for analysis, data entry, and point of care observations Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams Must be able to work with external regulatory agencies and accreditation groups Some "off-core business hours" work required Complete all company training requirement Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks This position is an on-site critical required position Other duties as assigned Education and Experience Requirements: PhD in a related subject area with demonstrated in vivo research experience in metabolic disease Postdoctoral or industry (2-5 years preferred) experience in genetic metabolic diseases Extensive hands-on experience with rodent in vivo work in the metabolic field This position is full-time on-site and based in Petaluma, CA with occasional work on site in San Rafael, CA Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

The Opportunity The Department of Discovery Oncology at Genentech is excited to announce an opportunity for a lab-based Scientist with a strong interdisciplinary background. This position will be part of the RAS-MAPK Signaling and Intervention Strategies Laboratory, which focuses on understanding oncogenic signaling mechanisms and developing novel therapeutic strategies targeting the Ras/MAPK pathway. The ideal candidate will have deep expertise in cell biology and oncogenic signaling pathways. This position will focus on discovering new targets and mechanisms of action in oncogenic signaling. The successful candidate will integrate molecular biology, cell biology, and protein biochemistry to investigate differences in signaling mechanisms in normal and cancer cells. Working closely with drug discovery project teams, translational medicine, and clinical development teams, you will help identify new therapeutic hypotheses and advance discovery and development of transformative medicines. Key responsibilities include: Interdisciplinary Collaboration: Work closely with internal experts across computational, research biology, and drug discovery disciplines to develop hypotheses and model systems that drive innovative therapeutic strategies. This will primarily be a wet-lab-based position. Supporting drug discovery projects: Perform cell biology and biochemistry experiments to characterize drug-like molecules and investigate their mechanisms of action. Translational Impact: Generate high-quality, original research that advances our understanding of cancer biology as well as contributing to the development of new therapies for oncologic indications. Who You Are Educational Background: Ph.D. in Biochemistry, Cell Biology, or a closely related field. Postdoctoral experience is preferred, but not essential. Experience: Your record should reflect sustained high-impact publications and/or patents, and substantial progress on projects that have deepened our understanding of cancer biology. Technical Expertise: Demonstrated expertise in cell biology techniques including transfection and stable cell line generation, organoid culture, CRISPR/Cas9 gene editing and screening; Demonstrated expertise in molecular biology techniques including IP, qPCR, western blots, FACS, IHC, RNAseq, ChIP-seq and analysis; cancer research, and biochemistry. Preferred Experience in the RAS-MAPK signaling pathway and induced proximity is a plus. Experience with or interest in leveraging AI/ML to accelerate research is a plus. A fearless scientist who tackles difficult problems, continuously develops new skills, and applies any technique or method necessary to advance our understanding of human cancers and discover new intervention strategies. If you are excited about working in a fast-paced, science-focused, and multi-disciplinary environment to uncover novel therapeutic targets for cancer and drive transformative medicines, we encourage you to apply. This role offers a unique opportunity to make a significant impact at the forefront of research and drug discovery at Genentech. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $103,400 - $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

The Opportunity The Department of Discovery Oncology at Genentech is excited to announce an opportunity for a lab-based Scientist with a strong interdisciplinary background. This position will be part of the RAS-MAPK Signaling and Intervention Strategies Laboratory, which focuses on understanding oncogenic signaling mechanisms and developing novel therapeutic strategies targeting the Ras/MAPK pathway. The ideal candidate will have deep expertise in cell biology and oncogenic signaling pathways. This position will focus on discovering new targets and mechanisms of action in oncogenic signaling. The successful candidate will integrate molecular biology, cell biology, and protein biochemistry to investigate differences in signaling mechanisms in normal and cancer cells. Working closely with drug discovery project teams, translational medicine, and clinical development teams, you will help identify new therapeutic hypotheses and advance discovery and development of transformative medicines. Key responsibilities include: * Interdisciplinary Collaboration: Work closely with internal experts across computational, research biology, and drug discovery disciplines to develop hypotheses and model systems that drive innovative therapeutic strategies. This will primarily be a wet-lab-based position. * Supporting drug discovery projects: Perform cell biology and biochemistry experiments to characterize drug-like molecules and investigate their mechanisms of action. * Translational Impact: Generate high-quality, original research that advances our understanding of cancer biology as well as contributing to the development of new therapies for oncologic indications. Who You Are * Educational Background: Ph.D. in Biochemistry, Cell Biology, or a closely related field. Postdoctoral experience is preferred, but not essential. * Experience: Your record should reflect sustained high-impact publications and/or patents, and substantial progress on projects that have deepened our understanding of cancer biology. * Technical Expertise: Demonstrated expertise in cell biology techniques including transfection and stable cell line generation, organoid culture, CRISPR/Cas9 gene editing and screening; Demonstrated expertise in molecular biology techniques including IP, qPCR, western blots, FACS, IHC, RNAseq, ChIP-seq and analysis; cancer research, and biochemistry. Preferred * Experience in the RAS-MAPK signaling pathway and induced proximity is a plus. * Experience with or interest in leveraging AI/ML to accelerate research is a plus. A fearless scientist who tackles difficult problems, continuously develops new skills, and applies any technique or method necessary to advance our understanding of human cancers and discover new intervention strategies. If you are excited about working in a fast-paced, science-focused, and multi-disciplinary environment to uncover novel therapeutic targets for cancer and drive transformative medicines, we encourage you to apply. This role offers a unique opportunity to make a significant impact at the forefront of research and drug discovery at Genentech. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $103,400 - $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

** **The Opportunity** The Department of Discovery Oncology at Genentech is excited to announce an opportunity for a lab-based Scientist with a strong interdisciplinary background. This position will be part of the RAS-MAPK Signaling and Intervention Strategies Laboratory, which focuses on understanding oncogenic signaling mechanisms and developing novel therapeutic strategies targeting the Ras/MAPK pathway. The ideal candidate will have deep expertise in cell biology and oncogenic signaling pathways. This position will focus on discovering new targets and mechanisms of action in oncogenic signaling. The successful candidate will integrate molecular biology, cell biology, and protein biochemistry to investigate differences in signaling mechanisms in normal and cancer cells. Working closely with drug discovery project teams, translational medicine, and clinical development teams, you will help identify new therapeutic hypotheses and advance discovery and development of transformative medicines. Key responsibilities include: + Interdisciplinary Collaboration: Work closely with internal experts across computational, research biology, and drug discovery disciplines to develop hypotheses and model systems that drive innovative therapeutic strategies. This will primarily be a wet-lab-based position. + Supporting drug discovery projects: Perform cell biology and biochemistry experiments to characterize drug-like molecules and investigate their mechanisms of action. + Translational Impact: Generate high-quality, original research that advances our understanding of cancer biology as well as contributing to the development of new therapies for oncologic indications. **Who You Are** + Educational Background: Ph.D. in Biochemistry, Cell Biology, or a closely related field. Postdoctoral experience is preferred, but not essential. + Experience: Your record should reflect sustained high-impact publications and/or patents, and substantial progress on projects that have deepened our understanding of cancer biology. + Technical Expertise: Demonstrated expertise in cell biology techniques including transfection and stable cell line generation, organoid culture, CRISPR/Cas9 gene editing and screening; Demonstrated expertise in molecular biology techniques including IP, qPCR, western blots, FACS, IHC, RNAseq, ChIP-seq and analysis; cancer research, and biochemistry. **Preferred** + Experience in the RAS-MAPK signaling pathway and induced proximity is a plus. + Experience with or interest in leveraging AI/ML to accelerate research is a plus. A fearless scientist who tackles difficult problems, continuously develops new skills, and applies any technique or method necessary to advance our understanding of human cancers and discover new intervention strategies. If you are excited about working in a fast-paced, science-focused, and multi-disciplinary environment to uncover novel therapeutic targets for cancer and drive transformative medicines, we encourage you to apply. This role offers a unique opportunity to make a significant impact at the forefront of research and drug discovery at Genentech. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $103,400 - $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. **Benefits (****************************************************** Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech, a member of the Roche Group. The Opportunity We have an exciting opportunity for an experienced scientific leader and medicinal chemist to join our Small Molecule Drug Discovery Chemistry Department at Genentech in South San Francisco, CA. The successful candidate will be responsible for leading drug discovery project teams through various stages of therapeutic target identification, druggability, preferred mode-of-action assessment, hit-finding enablement, hit-to-lead, and lead optimization in a multi-disciplinary, team-based culture. They will have particularly deep expertise in the early stages of drug discovery projects and would be working closely with therapeutic area leaders to evaluate potential targets. The position will entail responsibilities for influencing drug discovery practices and interacting directly with various functions such as Biochemical and Cellular Pharmacology, Drug Metabolism and Pharmacokinetics, Pharmaceutical Sciences, Safety Sciences, and Structural Biology. Who You Are * You will have a Ph.D. with 15+ years of medicinal chemistry experience in industry in the design and synthesis of analogs for molecular targets by applying state-of-the-art structure-driven and property-based design principles with deep experience in establishing and implementing successful partnerships with contract research organizations (CROs). * You will demonstrate a strong record of accomplishments as noted by significant and creative contributions to the success of small-molecule projects. * Lead, mentor, and provide career development for department staff and influence medicinal chemistry teams. * You will convey strong verbal and written communication skills and an ability to work collaboratively in teams. Preferred * Particular enthusiasm for mentoring colleagues across a wide range of experiences and disciplines is desired. The expected salary range for the Distinguished Scientist position based on the primary location of South San Francisco, CA is $196,100 - $364,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Relocation benefits are approved for this posting. #LI-KC2 Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech, a member of the Roche Group. The Opportunity We have an exciting opportunity for an experienced scientific leader and medicinal chemist to join our Small Molecule Drug Discovery Chemistry Department at Genentech in South San Francisco, CA. The successful candidate will be responsible for leading drug discovery project teams through various stages of therapeutic target identification, druggability, preferred mode-of-action assessment, hit-finding enablement, hit-to-lead, and lead optimization in a multi-disciplinary, team-based culture. They will have particularly deep expertise in the early stages of drug discovery projects and would be working closely with therapeutic area leaders to evaluate potential targets. The position will entail responsibilities for influencing drug discovery practices and interacting directly with various functions such as Biochemical and Cellular Pharmacology, Drug Metabolism and Pharmacokinetics, Pharmaceutical Sciences, Safety Sciences, and Structural Biology. Who You Are You will have a Ph.D. with 15+ years of medicinal chemistry experience in industry in the design and synthesis of analogs for molecular targets by applying state-of-the-art structure-driven and property-based design principles with deep experience in establishing and implementing successful partnerships with contract research organizations (CROs). You will demonstrate a strong record of accomplishments as noted by significant and creative contributions to the success of small-molecule projects. Lead, mentor, and provide career development for department staff and influence medicinal chemistry teams. You will convey strong verbal and written communication skills and an ability to work collaboratively in teams. Preferred Particular enthusiasm for mentoring colleagues across a wide range of experiences and disciplines is desired. The expected salary range for the Distinguished Scientist position based on the primary location of South San Francisco, CA is $196,100 - $364,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Relocation benefits are approved for this posting. #LI-KC2 Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

** A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech, a member of the Roche Group. **The Opportunity** We have an exciting opportunity for an experienced scientific leader and medicinal chemist to join our Small Molecule Drug Discovery Chemistry Department at Genentech in South San Francisco, CA. The successful candidate will be responsible for leading drug discovery project teams through various stages of therapeutic target identification, druggability, preferred mode-of-action assessment, hit-finding enablement, hit-to-lead, and lead optimization in a multi-disciplinary, team-based culture. They will have particularly deep expertise in the early stages of drug discovery projects and would be working closely with therapeutic area leaders to evaluate potential targets. The position will entail responsibilities for influencing drug discovery practices and interacting directly with various functions such as Biochemical and Cellular Pharmacology, Drug Metabolism and Pharmacokinetics, Pharmaceutical Sciences, Safety Sciences, and Structural Biology. **Who You Are** + You will have a Ph.D. with 15+ years of medicinal chemistry experience in industry in the design and synthesis of analogs for molecular targets by applying state-of-the-art structure-driven and property-based design principles with deep experience in establishing and implementing successful partnerships with contract research organizations (CROs). + You will demonstrate a strong record of accomplishments as noted by significant and creative contributions to the success of small-molecule projects. + Lead, mentor, and provide career development for department staff and influence medicinal chemistry teams. + You will convey strong verbal and written communication skills and an ability to work collaboratively in teams. **Preferred** + Particular enthusiasm for mentoring colleagues across a wide range of experiences and disciplines is desired. The expected salary range for the Distinguished Scientist position based on the primary location of South San Francisco, CA is $196,100 - $364,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits (**************************************************** Relocation benefits are approved for this posting. \#LI-KC2 Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .