Senior Principal Scientist jobs at Genentech

** A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech. **The Opportunity** We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team. This is a technical leadership position within our Peptide Therapeutics department, focused on advancing Peptide Therapeutics. The ideal candidate will be a significant contributor and a proven leader, responsible for optimizing and advancing novel peptide therapeutics into clinical development. You will lead the Medicinal Chemistry efforts for a highly integrated and collaborative team, applying your deep scientific expertise to solve complex drug discovery challenges and drive projects forward. Key Responsibilities + Drive the discovery of novel peptide therapeutics. Govern the design and synthesis of innovative peptides and peptidomimetics with enhanced potency, stability, and pharmacokinetic properties. + Lead scientific and project teams from concept to clinic. Initiate and lead new research projects, guiding them from early hit identification through lead optimization, with the ultimate goal of advancing promising compounds to clinical development. + Implement rational drug design strategies. Apply a broad repertoire of skills, including peptide synthesis, conformational analysis, and computational methods to implement strategic structure-activity relationship plans that optimize the pharmaceutical properties of peptide leads. + Champion cross-functional collaboration. Lead or co-lead multidisciplinary teams, serving as a key scientific partner to colleagues in Research Biology and Drug Discovery to overcome complex challenges associated with the development of peptide therapeutics. + Provide scientific leadership and mentorship. Supervise and mentor junior scientists, contribute to the prioritization of team objectives, and propose future strategies to meet broader portfolio goals. + Ensure data integrity and project success. Oversee the analysis and interpretation of complex analytical data, including mass spectrometry, HPLC, and NMR, to confirm compound identity and purity. You will be responsible for managing multiple projects simultaneously, delivering high-quality results on time. **Who You Are** + Education: Ph.D. or postdoctoral degree in Organic Chemistry, Medicinal Chemistry, or a related field. + Experience: A minimum of 7 years of experience in the biotechnology or pharmaceutical industry, with a proven track record of advancing drug candidates from the conceptual stage into clinical testing. Technical Expertise: + Demonstrated mastery in complex molecule organic synthesis, including proficiency in both automated solid-phase peptide synthesis, and solution-phase small molecule synthesis, utilizing state-of-the-art protecting group and purification strategies. + Must possess expertise in high-throughput and parallel synthesis for library generation, coupled with the expert ability to analyze and interpret all relevant analytical data (HPLC, Mass Spectrometry, NMR) to confirm the identity and purity of all synthesized drug candidates. + Required experience in designing, developing, and implementing novel synthetic routes to overcome challenging chemical and physicochemical issues associated with optimizing both peptide and small molecule scaffolds. + Must possess deep experience in the design and multi-step synthesis of novel, non-commercial building blocks and scaffolds to enable SAR exploration and overcome property liabilities. + Deep knowledge of macrocyclic peptides, including the properties required for different routes of administration (i.e. IV vs SC vs PO, etc), and related library-based screening technologies (e.g., OBOC, mRNA display, AS/MS). Computational Methods: + Experience with computational modeling and simulation for peptide design and optimization, including conformational sampling and molecular dynamics (MD) simulations. + Proficiency in structure-based drug design and ligand-based drug design to guide peptide modifications. + Familiarity with machine learning and AI-driven platforms for predicting peptide properties, optimizing sequences, and generating novel scaffolds. + Experience using common computational chemistry software (e.g., Schrödinger, MOE, Maestro, or similar). Leadership & Collaboration: + Demonstrated success in a leadership role, guiding multidisciplinary teams to deliver drug candidates. + Exceptional communication and presentation skills, with the ability to inspire and lead within a globally matrixed organization. + A highly collaborative and transparent style, with a proven ability to mentor junior scientists and build strong relationships across all levels of the organization. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $168,600 to $313,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. **Benefits (****************************************************** \#LI-KC2 Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech. The Opportunity We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team. This is a technical leadership position within our Peptide Therapeutics department, focused on advancing Peptide Therapeutics. The ideal candidate will be a significant contributor and a proven leader, responsible for optimizing and advancing novel peptide therapeutics into clinical development. You will lead the Medicinal Chemistry efforts for a highly integrated and collaborative team, applying your deep scientific expertise to solve complex drug discovery challenges and drive projects forward. Key Responsibilities Drive the discovery of novel peptide therapeutics. Govern the design and synthesis of innovative peptides and peptidomimetics with enhanced potency, stability, and pharmacokinetic properties. Lead scientific and project teams from concept to clinic. Initiate and lead new research projects, guiding them from early hit identification through lead optimization, with the ultimate goal of advancing promising compounds to clinical development. Implement rational drug design strategies. Apply a broad repertoire of skills, including peptide synthesis, conformational analysis, and computational methods to implement strategic structure-activity relationship plans that optimize the pharmaceutical properties of peptide leads. Champion cross-functional collaboration. Lead or co-lead multidisciplinary teams, serving as a key scientific partner to colleagues in Research Biology and Drug Discovery to overcome complex challenges associated with the development of peptide therapeutics. Provide scientific leadership and mentorship. Supervise and mentor junior scientists, contribute to the prioritization of team objectives, and propose future strategies to meet broader portfolio goals. Ensure data integrity and project success. Oversee the analysis and interpretation of complex analytical data, including mass spectrometry, HPLC, and NMR, to confirm compound identity and purity. You will be responsible for managing multiple projects simultaneously, delivering high-quality results on time. Who You Are Education: Ph.D. or postdoctoral degree in Organic Chemistry, Medicinal Chemistry, or a related field. Experience: A minimum of 7 years of experience in the biotechnology or pharmaceutical industry, with a proven track record of advancing drug candidates from the conceptual stage into clinical testing. Technical Expertise: Demonstrated mastery in complex molecule organic synthesis, including proficiency in both automated solid-phase peptide synthesis, and solution-phase small molecule synthesis, utilizing state-of-the-art protecting group and purification strategies. Must possess expertise in high-throughput and parallel synthesis for library generation, coupled with the expert ability to analyze and interpret all relevant analytical data (HPLC, Mass Spectrometry, NMR) to confirm the identity and purity of all synthesized drug candidates. Required experience in designing, developing, and implementing novel synthetic routes to overcome challenging chemical and physicochemical issues associated with optimizing both peptide and small molecule scaffolds. Must possess deep experience in the design and multi-step synthesis of novel, non-commercial building blocks and scaffolds to enable SAR exploration and overcome property liabilities. Deep knowledge of macrocyclic peptides, including the properties required for different routes of administration (i.e. IV vs SC vs PO, etc), and related library-based screening technologies (e.g., OBOC, mRNA display, AS/MS). Computational Methods: Experience with computational modeling and simulation for peptide design and optimization, including conformational sampling and molecular dynamics (MD) simulations. Proficiency in structure-based drug design and ligand-based drug design to guide peptide modifications. Familiarity with machine learning and AI-driven platforms for predicting peptide properties, optimizing sequences, and generating novel scaffolds. Experience using common computational chemistry software (e.g., Schrödinger, MOE, Maestro, or similar). Leadership & Collaboration: Demonstrated success in a leadership role, guiding multidisciplinary teams to deliver drug candidates. Exceptional communication and presentation skills, with the ability to inspire and lead within a globally matrixed organization. A highly collaborative and transparent style, with a proven ability to mentor junior scientists and build strong relationships across all levels of the organization. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $168,600 to $313,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits #LI-KC2 Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech. The Opportunity We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team. This is a technical leadership position within our Peptide Therapeutics department, focused on advancing Peptide Therapeutics. The ideal candidate will be a significant contributor and a proven leader, responsible for optimizing and advancing novel peptide therapeutics into clinical development. You will lead the Medicinal Chemistry efforts for a highly integrated and collaborative team, applying your deep scientific expertise to solve complex drug discovery challenges and drive projects forward. Key Responsibilities * Drive the discovery of novel peptide therapeutics. Govern the design and synthesis of innovative peptides and peptidomimetics with enhanced potency, stability, and pharmacokinetic properties. * Lead scientific and project teams from concept to clinic. Initiate and lead new research projects, guiding them from early hit identification through lead optimization, with the ultimate goal of advancing promising compounds to clinical development. * Implement rational drug design strategies. Apply a broad repertoire of skills, including peptide synthesis, conformational analysis, and computational methods to implement strategic structure-activity relationship plans that optimize the pharmaceutical properties of peptide leads. * Champion cross-functional collaboration. Lead or co-lead multidisciplinary teams, serving as a key scientific partner to colleagues in Research Biology and Drug Discovery to overcome complex challenges associated with the development of peptide therapeutics. * Provide scientific leadership and mentorship. Supervise and mentor junior scientists, contribute to the prioritization of team objectives, and propose future strategies to meet broader portfolio goals. * Ensure data integrity and project success. Oversee the analysis and interpretation of complex analytical data, including mass spectrometry, HPLC, and NMR, to confirm compound identity and purity. You will be responsible for managing multiple projects simultaneously, delivering high-quality results on time. Who You Are * Education: Ph.D. or postdoctoral degree in Organic Chemistry, Medicinal Chemistry, or a related field. * Experience: A minimum of 7 years of experience in the biotechnology or pharmaceutical industry, with a proven track record of advancing drug candidates from the conceptual stage into clinical testing. Technical Expertise: * Demonstrated mastery in complex molecule organic synthesis, including proficiency in both automated solid-phase peptide synthesis, and solution-phase small molecule synthesis, utilizing state-of-the-art protecting group and purification strategies. * Must possess expertise in high-throughput and parallel synthesis for library generation, coupled with the expert ability to analyze and interpret all relevant analytical data (HPLC, Mass Spectrometry, NMR) to confirm the identity and purity of all synthesized drug candidates. * Required experience in designing, developing, and implementing novel synthetic routes to overcome challenging chemical and physicochemical issues associated with optimizing both peptide and small molecule scaffolds. * Must possess deep experience in the design and multi-step synthesis of novel, non-commercial building blocks and scaffolds to enable SAR exploration and overcome property liabilities. * Deep knowledge of macrocyclic peptides, including the properties required for different routes of administration (i.e. IV vs SC vs PO, etc), and related library-based screening technologies (e.g., OBOC, mRNA display, AS/MS). Computational Methods: * Experience with computational modeling and simulation for peptide design and optimization, including conformational sampling and molecular dynamics (MD) simulations. * Proficiency in structure-based drug design and ligand-based drug design to guide peptide modifications. * Familiarity with machine learning and AI-driven platforms for predicting peptide properties, optimizing sequences, and generating novel scaffolds. * Experience using common computational chemistry software (e.g., Schrödinger, MOE, Maestro, or similar). Leadership & Collaboration: * Demonstrated success in a leadership role, guiding multidisciplinary teams to deliver drug candidates. * Exceptional communication and presentation skills, with the ability to inspire and lead within a globally matrixed organization. * A highly collaborative and transparent style, with a proven ability to mentor junior scientists and build strong relationships across all levels of the organization. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $168,600 to $313,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits #LI-KC2 Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at ******************* Job Function: Data Analytics & Computational Sciences Job Sub Function: Data Science Job Category: Scientific/Technology All Job Posting Locations: Cambridge, Massachusetts, United States of America, La Jolla, California, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America Job Description: Johnson & Johnson Innovative Medicine is recruiting a Senior Principal Scientist for R&D Data Science and Digital Health, Real-World Evidence Prefered Location: Raritan / Titusville, NJ; Cambridge, MA; or Spring House, PA. May consider remote work. Johnson & Johnson Innovative Medicine develops treatments that improve the health of people worldwide. Research and development areas encompass oncology, cardiovascular and metabolic disorders, immunology, pulmonary hypertension, retinal disorders, and neuroscience. Our goal is to help people live longer, healthier lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market - from patients to practitioners and from clinics to hospitals. To learn more about Janssen, one of the Pharmaceutical Companies of Johnson & Johnson, visit ************************************************************ The Data Science Real-World Evidence Analytics & Insights team within Johnson and Johnson Innovative Medicines develops innovative insights and solutions bringing to bear a variety of different data sources across multiple disease areas. We are looking for outstanding scientist and leader whose responsibilities include: * Be a hands-on technical leader, leading a portfolio of RWE projects while instituting best practices, and developing common technical tools, crafting a data-driven culture, of accelerating, scaling and productionalizing deliverables while mentoring and educating peers in the adoption of technical best practices and common tools. * End-to-end expertise in RWE studies including conceptualizing the research questions, data feasibility, study design, analysis, programming, and interpretation. * Provide thought leadership and hand-on programming expertise for developing, adapting and delivering Real-World Data ("RWD") methodologies to mitigate observed and unobserved bias and confounding in the execution of comparative effectiveness analyses, time-to-event analyses, external control arm studies, hybrid control arm studies, retrospective and prospective study designs. * Provide thought leadership and hand-on programming expertise to generating RWE or secondary evidence from post-hoc RCT analyses, observational databases, and literature reviews to support regulatory agency interactions. * Independently create study protocols, statistical analysis plans, and statistical programming deliverables including analysis-ready data, tables, and figures using appropriate statistical analysis software while instituting best practices for execution across the broader team. * Experience creating pipelines, functions, packages to perform frequently used actions and/or deliverables across broad group of stakeholders. * Partner with the Data Science Therapeutic Area scientists to conceptualize, lead, shape and deliver Real World Evidence, and advanced analytics solutions and insights for prioritized use cases taking ownership of one or more disease area evidence generation teams. * Partner closely with R&D DSDH Real-World Evidence LT team to drive strategic and business planning, to take a leading role in facilitating cross-functional operational initiatives, ensuring effective coordination and seamless execution to drive the overall success of Real-World Evidence projects. * Contribute to the development and implementation of best practices, process improvements, and innovative approaches that will further enhance the impact of the Real-World Evidence team. * Contribute to the development and implementation of RW data strategy by identifying and exploring new opportunities for data-driven innovation to support business objectives. * Partner with the Data Science stakeholders to lead and coordinate policy efforts to influence the regulatory acceptability of RWE in decision making. Required qualifications: * A Ph.D. degree, or master's degree in a quantitative field (e.g., epidemiology, statistics, biostatistics, or similar) * At least 5 years of relevant experience within start-up, technology, biopharma or healthcare industries, or highly relevant academic experience, on a case-by-case basis * Extensive hands-on experience with data engineering and exploratory data analysis, statistical modeling, time-to-event analyses, comparative effectiveness analyses, causal inference methods to mitigate observed and residual confounding (e.g., propensity score matching/weighting, instrumental variables, state transition models) * Demonstrated expertise with multiple real-world data sources (EHR, insurance claims, registry data). Familiarity with data structure and programming of clinical trial data * Excellent interpersonal, communication and presentation skills * Extensive experience with database programming and use of statistical programming languages including expert proficiency in either, R or Python working proficiency in SAS and SQL * Demonstrated experience as a technical lead in developing, testing and maintaining technical frameworks for RWE analyses * Extensive knowledge of RWE Common Data Models (OMOP, FHIR, i2b2) & Analysis frameworks (OHDSI, pharmaverse) * Demonstrated experience in managing operations, with strong stakeholder management capabilities. * Demonstrated experience in business planning, resource allocation and prioritization Preferred qualifications: * Familiarity with drug discovery and the clinical development process * Expertise in Oncology, Immunology or Neuroscience drug development * Experience in regulatory-grade evidence, communicating and responding to agency reviews and comments. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (********************************) or contact AskGS to be directed to your accommodation resource. #LI-GR #LI-Hybrid #JRDDS #JNJDataScience #JRD Required Skills: Preferred Skills: The anticipated base pay range for this position is : $137,000 - $235,750 Additional Description for Pay Transparency: Additional Description for Pay Transparency Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. § Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). § Employees are eligible for the following time off benefits: - Vacation - up to 120 hours per calendar year - Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year - Holiday pay, including Floating Holidays - up to 13 days per calendar year - Work, Personal and Family Time - up to 40 hours per calendar year Additional information can be found through the link below.

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible. Position Summary: Illumina is a global leader in genomics, dedicated to advancing healthcare through continuous innovation. We are seeking a visionary leader to join our Advanced Sciences department in the area of protein engineering. Depending on experience, career aspirations, and business needs, candidates may be considered for either the Sr Director or Sr Principal Scientist role. This role offers the opportunity to shape the future of genomics and multiomics applications, lead cutting-edge research, and collaborate across disciplines. The successful candidate will provide strategic and technical leadership for the Protein Engineering function, influencing technology roadmaps and driving the development of innovative products. The Sr Director will additionally manage the Protein Engineering function in the US. We encourage candidates of all backgrounds and experiences to apply, including those who may not meet every requirement but are excited about the opportunity to contribute to our mission and can provide a competitive advantage in other aspects of the role. Responsibilities: * Shape and communicate the strategic vision for the protein engineering group, leading teams to execute on that vision. * Evaluate product needs in the marketplace and provide strategic research direction for protein/enzyme improvements to enhance existing and novel products. * Analyze internal and external assay capabilities to help create a market-leading product portfolio. * Develop strategies to ensure effective and efficient achievement of company objectives for genomics and multiomics markets as they pertain to protein engineering. * Translate strategy into executable operating plans, collaborating with peers across the organization to align and execute on strategic roadmaps. * Establish cross-department and cross-functional collaborations to ensure project and program needs are met by the protein engineering team. * Lead technology research and development teams in a highly matrixed organization. * Manage and/or influence program and project leaders to ensure progress on multiple projects and programs remains on track. * Develop and manage budgets for large capital expenditures and labor costs. * Maintain a comprehensive understanding of NGS workflows, from sample acquisition to data analysis. * Understand molecular details of NGS systems, including library preparation and sequencing chemistry. * Write and review publications (e.g., marketing collateral, scientific papers) and present to the Illumina executive team, board of directors, and at scientific conferences. Listed responsibilities are not an exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs Requirements: * Expertise in the latest protein engineering techniques and methods; familiarity with DNA polymerases, transposases, reverse transcriptases, nanopores and other nucleic acid binding or modifying enzymes. * Demonstrated leadership skills with a track record of developing and mentoring senior leaders and individual contributors in diverse contexts. * Deep knowledge of Next Generation Sequencing (NGS) and hands-on experience with library preparation for Illumina sequencing systems or other sequencing technologies. * Experience in taking conceptual research through development to a viable product for commercialization. * Strong program and project management skills, including scope, scheduling, budget, and resource management. * Excellent presentation skills for diverse audiences. All listed requirements are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional task and responsibilities. Experience/Education: * PhD in Biological Sciences, Chemical Biology or equivalent experience. * Typically requires a Bachelor's degree and a minimum of 20 years of related experience, with 12+ years of Management experience. * Experience managing and mentoring senior-level PhD scientists across various disciplines while overseeing product development projects. * Broad knowledge of all areas within protein engineering. * Deep technical knowledge in a variety of functions, gained from experience in both non-management and management roles. If you are passionate about advancing science and technology, and excited to contribute to Illumina's mission, we encourage you to apply, even if your experience doesn't precisely match every requirement. We look forward to learning how your unique background and perspective can help us unlock the power of the genome. The estimated base salary range for the Sr Director/ Sr Principal Scientist, Protein Engineering role based in the United States of America is: $220,500 - $330,700. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. Compensation decisions are dependent on several factors including, but not limited to, an individual's qualifications, location where the role is to be performed, internal equity, and alignment with market data. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off. We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact accommodations@illumina.com. To learn more, visit: ****************************************************************** The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at ******************* Job Function: Data Analytics & Computational Sciences Job Sub Function: Data Science Job Category: Scientific/Technology All Job Posting Locations: Cambridge, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America Job Description: Johnson & Johnson Innovative Medicine R&D Data Science and Digital Health is recruiting for a Senior Principal Data Scientist, Real World Evidence (RWE). The primary location for this position is flexible - Titusville, NJ; Raritan, NJ; Spring House, PA; Cambridge, MA; or San Diego, CA. May consider remote on a case by case basis J&J Innovative Medicine develops treatments that improve the health of people worldwide. Research and development areas encompass oncology, immunology, neuroscience, cardiopulmonary and specialty ophthalmology. Our goal is to help people live longer, healthier lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market - from patients to practitioners and from clinics to hospitals. To learn more about Johnson & Johnson Innovative Medicine visit *********************************** The R&D Data Science & Digital Health, Real-World Evidence (RWE) team at J&J Innovative Medicine is dedicated to developing innovative evidence solutions and critical insights through diverse data sources, including RWD, trial data and emerging innovative data sources, to support clinical programs and regulatory decision-making. The Senior Principal Data Scientist will collaborate closely with strategic partners in R&D Data Science and Digital Health, as well as multidisciplinary teams within J&J Innovative Medicine, to develop and implement evidence and insights to improve patient outcomes and accelerate clinical development in Oncology, Immunology, or Neuroscience. Key Responsibilities: * Be a hands-on technical leader, leading a portfolio of RWE projects while developing best practices and common technical tools * Support the development of the R&D RWE strategy for the generation and utilization of RWE for our key pipeline assets * End-to-end expertise in RWE studies (external control arm, novel endpoints, trial design optimization) including conceptualizing research questions, data feasibility, study design, analysis, programming, and interpretation * Assess treatment patterns and unmet needs using RWE to inform asset positioning * Ensure RWE generation aligned with regulatory requirements and scientific standards * Identify evidence opportunities and develop innovative evidence programs to support early development, registration, and post-marketing phases * Shape the selection of real-world data sources, establish data quality standards, and ensure data robustness and relevance for clinical research * Lead and develop junior researchers and programmers in executing strategies to develop RWE from concept through publication * Support regulatory interactions and meetings with scientific data packages and expertise Required Qualifications: * A Ph.D. degree, or master's degree in a quantitative field (e.g., epidemiology, biostatistics, statistics, or similar) * Relevant experience (4+ years for Ph.D., 6+ years for a master's) within biopharma companies, RWE consulting firms, or other relevant healthcare industries * Extensive hands-on experience with data engineering and exploratory data analysis, statistical modeling, time-to-event analyses, comparative effectiveness analyses, causal inference methods * Demonstrated expertise with multiple real-world data sources * Expert proficiency in R and SQL * Familiarity with data structure and programming of clinical trial data * Strong communication and influencing skills, capable of inspiring teams and driving cross-functional alignment * Highly motivated and intellectually curious, with strong executional rigor and a passion for solving complex challenges Preferred Qualifications: * Familiarity with drug discovery and the clinical development process * Expertise in oncology, Immunology or Neuroscience drug development * Experience in regulatory-grade evidence, communicating and responding to agency reviews and comments Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (********************************) or contact AskGS to be directed to your accommodation resource. #LI-GR #LI-Hybrid #JRDDS #JNJDataScience #JRD Required Skills: Preferred Skills: The anticipated base pay range for this position is : $137,000 - $235,750 Additional Description for Pay Transparency: Additional Description for Pay Transparency Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. § Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). § Employees are eligible for the following time off benefits: - Vacation - up to 120 hours per calendar year - Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year - Holiday pay, including Floating Holidays - up to 13 days per calendar year - Work, Personal and Family Time - up to 40 hours per calendar year Additional information can be found through the link below.

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at ******************* Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Nonclinical Safety Job Category: Scientific/Technology All Job Posting Locations: San Diego, California, United States of America, Spring House, Pennsylvania, United States of America Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at *******************/innovative-medicine Johnson & Johnson Innovative Medicine R&D is recruiting for a Senior Principal Scientist, Nonclinical Submissions Writer. This position is a hybrid role and can be located in Spring House, PA or San Diego, CA. The Senior Principal Scientist, Nonclinical Submissions Writer, within the Preclinical Sciences and Translational Safety (PSTS) organization, will prepare and review regulatory submission documents that summarize toxicology, safety pharmacology, drug metabolism, and pharmacokinetics studies. This role will collaborate closely with nonclinical safety, pharmacokinetic (PK) and discovery biology project leads, medical writers, global regulatory dossier leaders, and other subject matter experts (SMEs) to drive the integrated assessment of all nonclinical data in dossiers for submission to international health authorities. This individual will represent PSTS as the main point of contact on cross-functional global dossier teams and ensure delivery of state-of-the-art submissions aligned with global requirements Principal Responsibilities: * Generate nonclinical submission documents to meet pipeline goals with timely, high-quality deliverables (e.g., Investigator's Brochures, IND/CTA/NDA nonclinical modules, briefing books, health authority responses) across all programs and development phases. * Partner with Nonclinical Safety, Drug Metabolism and Pharmacokinetics, Bioanalytical, and Pharmacology Leads and other SMEs to develop clear storytelling in submissions by positioning key messages, providing robust context, and clearly explained risk assessments. * Plan, write, review, edit, and finalize nonclinical sections of regulatory documents for development compounds and marketed products; represent nonclinical on cross-functional teams; coordinate writing activities and timelines. * Support the implementation of best practices and continuous improvement; maintain adherence to Standard Operating Procedures (SOPs) and regulatory requirements in partnership with nonclinical, statistical, clinical, regulatory, and quality colleagues. * Engage in development, evaluation, and implementation of generative Artificial Intelligence (AI) writing and Quality Control (QC) tools for regulatory document generation. * Collaborate with Global Document Specialists and Global SEND (Standardization for Exchange of Nonclinical Data) managers to prepare submission-ready components and ensure the technical and scientific correctness of SEND data. * Work effectively in a global, matrix environment across different time zones. * Adhere to timelines; proactively identify and communicate submission-related issues and develop contingency plans. Qualifications: * A minimum of a Master's degree in Biomedical Sciences, Toxicology, Pharmacology, or a related discipline is required. Advanced degree (PharmD, Ph.D. or equivalent) in Biomedical Sciences, Toxicology, Pharmacology, or a related discipline is preferred. * A minimum of 8 years of relevant experience in nonclinical drug development is required. * Extensive experience with summary document writing supporting diverse modalities and therapeutic areas is required. * Strong writing skills coupled with a good understanding of electronic submission requirements required. * Knowledge of Good Laboratory Practice (GLP) standards is required. * Knowledge of regulatory requirements specific to nonclinical modules is required. * Knowledge of ICH (International Council for Harmonization of Technical Requirements of Pharmaceuticals for Human Use) guidelines, FDA and EMA/CHMP regulations and guidelines, and other international regulatory requirements, is required. * Experience handling multiple, dynamic programs with competing and aggressive timelines in a matrix environment is required. * Must have excellent communication and interpersonal skills. * Must have strong negotiating, troubleshooting and organizational skills. * Must have strong attention to detail. * The ability to integrate data, highlight key messages, and infuse storytelling into nonclinical submission documents is required. * The ability to collaborate effectively in a cross-functional team environment is required. * This position will require up to 10% domestic and international travel. The anticipated base pay range for this position in all other U.S. locations is $137,000 to $235,750. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/ performance year. Bonuses are awarded at the Company's discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). Employees are eligible for the following time off benefits: * Vacation - up to 120 hours per calendar year * Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year * Holiday pay, including Floating Holidays - up to 13 days per calendar year * Work, Personal and Family Time - up to 40 hours per calendar year For additional general information on company benefits, please go to: ********************************************* The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market. This job posting is anticipated to close on November 21, 2025. The Company may however extend this time-period, in which case the posting will remain available on *************************** to accept additional applications. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (********************************) or contact AskGS to be directed to your accommodation resource. #LI-Hybrid Required Skills: Preferred Skills: Clinical Data Management, Drug Discovery Development, EHS Compliance, Emergency Planning, Performance Measurement, Presentation Design, Process Hazard Analysis (PHA), Process Optimization, Program Management, Regulatory Affairs Management, Research and Development, Risk Management, Safety Audits, Safety Investigations, Safety-Oriented, Scientific Research, Strategic Thinking, Tactical Planning, Technical Credibility The anticipated base pay range for this position is : The anticipated base pay range for this position in all other U.S. locations is $137,000 to $235,750. Additional Description for Pay Transparency: Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Subject to the terms of their respective plans, employees are eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Company's long-term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation -120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Washington -56 hours per calendar year Holiday pay, including Floating Holidays -13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year Parental Leave - 480 hours within one year of the birth/adoption/foster care of a child Condolence Leave - 30 days for an immediate family member: 5 days for an extended family member Caregiver Leave - 10 days Volunteer Leave - 4 days Military Spouse Time-Off - 80 hours Additional information can be found through the link below. *********************************************

Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. We are seeking a Senior Scientist 1 - Biophysical Characterization & Bioconjugation to lead analytical strategy and experimental design for therapeutic proteins and their bioconjugates-particularly enzyme- and antibody-based platforms. You will join the Biologics Therapeutic Modality Team, developing advanced biophysical workflows, designing custom assays to define structure-function relationships, and guiding conjugation strategies for next-generation molecules. Your contributions will directly influence lead candidate selection, manufacturability, and regulatory readiness, helping advance promising therapies from bench to clinic. Key Responsibilities * Strategic Leadership in Biophysical Characterization * Lead biophysical characterization strategies for protein-based therapeutics (enzymes, antibodies, fusion proteins) and, as appropriate, other modalities such as nanoparticles and/or small molecules. * Apply bioconjugation chemistry expertise to optimize critical product attributes such as half-life, specificity, and developability. * Assay Development & Innovation * Develop, optimize, and validate fit-for-purpose and high-throughput assays to assess higher-order structure, aggregation, stability, and binding interactions. * For bioconjugates, evaluate conjugation efficiency, site occupancy, DAR/DPR, linker/payload stability, degradation profiles, and serum/matrix stability. * Deliver well-documented, phase-appropriate analytical packages suitable for internal or CRO execution (development → qualification → transfer). * Cross-Functional Collaboration * Partner with Discovery, Therapeutic Development, Analytical Sciences, Protein Engineering, Formulation, and Regulatory teams to integrate biophysical insights and support decision-making at key development milestones. * Technology Transfer & External Partnerships * Lead technology transfer of assays and workflows to Analytical Sciences or external partners (CROs/CDMOs), ensuring SOP completeness, acceptance criteria, comparability plans, and data integrity standards. * Scientific Innovation & External Engagement * Stay current on bioconjugation and analytical biophysics innovations (e.g., mass photometry, HDX-MS, native/denaturing MS for DAR and site occupancy, FcRn assays). * Evaluate and implement emerging platforms to strengthen data quality and reduce program risk. * Regulatory Support * Prepare analytical reports and datasets supporting IND/CTA submissions. * Contribute to comparability assessments and respond to health authority queries in collaboration with CMC and Quality. * Mentorship & Culture Building * Act as a player-coach, mentoring junior scientists, maintaining high data integrity standards, and promoting a culture of excellence, innovation, and accountability. Qualifications * Education: * Ph.D. in Biophysics, Biochemistry, Pharmaceutical Sciences, or Chemical/Biomedical Engineering preferred. * M.S. or B.S. with significant industry experience will be considered. * Experience: * Ph.D. with 6+ years, M.S. with 10+ years, or B.S. with 12+ years of relevant experience in biophysical and analytical characterization of biologics. * Proven success with therapeutic protein conjugates (enzymes, antibodies, fusion proteins). Experience with small-molecule or nanoparticle conjugates is an advantage. * Technical Expertise: * Working knowledge or hands-on experience in at least one or two methods per category: * Size/Assembly: SEC-MALS, FFF-MALS, AUC, DLS, Mass Photometry * Structure/Stability: DSC, DSF, CD, FTIR, HDX-MS (preferred) * Binding/Mechanism: SPR, BLI, ITC, MST * Chromatography/Charge/Identity: HIC, IEX, RP-HPLC, CE-SDS, cIEF, LC-MS (intact mass, peptide mapping; native/denaturing for DAR/site occupancy) * Conjugation Analytics: DAR/DPR analysis, linker/payload stability, forced degradation, serum/matrix stability * Regulatory & CMC: * Experience contributing to IND/CTA filings and supporting method lifecycle management for complex biologics and conjugates. Core Competencies * Strong experimental design, quantitative analysis, and problem-solving skills * Clear written and verbal communication * Ability to lead and collaborate within cross-functional, matrixed teams * Experience managing CRO/CDMO deliverables Preferred Qualifications * Experience establishing release and stability testing panels for biologics or conjugates * Demonstrated success transferring analytical methods to/from CROs/CDMOs, including full documentation and comparability packages * Familiarity with regulatory submissions and agency interactions for bioconjugates or ADCs * Evidence of scientific innovation, such as peer-reviewed publications, patents, or conference presentations Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. The salary range for this position is: $128,000 to $176,000. BioMarin considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans. For additional benefits information, visit:

As part of Pharma Technical Development (PTD) our organization is committed to deliver the Pharma ambitions by bringing game-changing therapies from clinical phase I into the market to serve every patient, every day. Our core business is to develop safe, innovative and effective drugs using cutting edge technologies for manufacturing process (Drug Substance and Drug Product), clinical supply, formulation, device, packaging, and analytical development. Together with our partners, Global Biologics Bioprocess Development develops robust, efficient, and sustainable bioprocesses including Cell Line & Media Development, Cell Culture & Fermentation, and Purification Development. The Cell Culture Development US organization provides innovative technologies and strategic support for development and commercialization of Genentech and Roche's biologic portfolio, including standard monoclonal antibodies as well as complex and modified proteins such as antibody drug conjugates and bispecific antibodies. The Roche/Genentech biological portfolio spans late stage research (LSR), preclinical, clinical, and initial marketing authorization. The department of Cell Culture and Bioprocess Operations (CCBO) within Genentech's Pharma Technical Development (PTD) organization is seeking a highly experienced and self-motivated senior-level scientist to lead cell culture media development efforts for a diverse range of biological products. The ideal candidate for this role will have extensive cell culture media development experience and demonstrated strengths in fostering teamwork and collaboration with an inclusive mindset. The Opportunity The successful candidate will lead media development for mammalian cell lines expressing therapeutic antibodies, bispecific antibodies, complex biologics and other new modalities including gene and cell therapies. The successful candidate will provide scientific and strategic guidance to establish highly-productive next-generation platform processes in collaboration with multiple stakeholders within and outside CCBO/PTD. This position requires a passion for scientific rigor and excellent skills in leadership, communication, strategic thinking, decision making, influencing, and problem solving. The location for this role is our US Headquarters in South San Francisco, CA. Responsibilities Develop chemically-defined cell culture media to meet different needs, including high-density cultures for biologics manufacturing, and cell-based therapies. Innovate, define strategies, and apply advanced technologies to improve cell culture performance and establish next-generation platform processes. Serve as primary in-house expert for state-of-the-art practice in media development. Provide technical leadership and strategic guidance to support technical/product teams, media preparation operations, raw material assessments, and supply chain updates. Guide, motivate, and develop staff in the Media and Process Group (MPG) within CCBO, with emphasis on defining their technical priorities and focus. Cultivate a lean mindset with focus on simplification and continuous improvement. Interface effectively within CCBO department and PTD, as well as with other internal Genentech/Roche organizations and external collaborators. Anticipate, identify, and resolve issues, with escalation and stakeholder communication where appropriate. Exert influence inside and outside the company through presentations, publications, and participation in meetings. Who you are The successful candidate will have an established track record for strong technical leadership in cell culture media development. Other requirements for this role include: PhD (biological sciences, chemical engineering or related discipline) with 10+ years of relevant work experience OR BS/MS (biological sciences, chemical engineering or related discipline) with 14+ years of relevant work experience. Solid understanding of cell metabolism and tools for metabolic pathway analyses. Expertise in using computational methods, metabolic models, statistical design of experiments, -omics, and other current technologies to improve cell culture processes. Prior experience in media development for mammalian cell cultures. Prior experience in technology transfer and development of cell-based therapies is a plus. Demonstrated ability to lead and drive technical projects to completion through scientific rigor and strong organization skills. Proven track record of managing and developing highly productive technical teams with an inclusive mindset. Proven track record of building and maintaining strong relationships with partners, customers, and collaborators. Proven track record of excellent verbal and written communication through conference presentations and publications. This is an onsite position based out of South San Francisco, California, USA. Relocation benefits are available for this position. The expected salary range for this position based on the primary location of South San Francisco, CA is $180,700 to $335,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. We are seeking a motivated Scientist with experience in genetic metabolic diseases to join our team. The Scientist will join the Enzymatic and Metabolic In Vivo team to design and execute key in vivo studies focused on developing therapeutics to transform the lives of people with genetic metabolic disorders. This role reports into the In Vivo Lead. The primary role of the Scientist will be in design and execution of in vivo studies as part of the Enzymatic and Metabolic In Vivo Team. They will work collaboratively across the Research and Early Development Department to identify, develop and execute project strategies for in vivo testing of novel therapeutics. Areas of focus will span from animal model development to testing novel therapeutic approaches for genetic metabolic disorders. The successful candidate will have a strong background in metabolic and enzymatic biology, with demonstrated experience in the use of model systems in research. Experience with in vivo models of disease and a collaborative mindset is critical. While some industry experience is a plus, it is not required. The successful candidate will contribute in vivo model evaluation and support to project teams that support the project goals. Including in vivo study design, hands on in vivo study performance, selection and characterization of animal models, as well as application of in vivo methods and techniques. Strong written communication skills are critical for FDA filings, writing IACUC protocols, communicating scientific strategy, monitoring in vivo studies and collaborating with CRO's, tissue collection, and sample management. The successful candidate will also have experience with in vivo technical tasks including but not limited to dosing techniques (SC, IP, IV, RO, PO), blood collection (tail nick, saphenous vein puncture), and IVIS imaging. The ideal candidate will have Postdoctoral Academic or Biotech/Pharma industry in vivo experience in the metabolic disease field. The ideal candidate will have hands-on experience with animal models of metabolic/enzymatic disease, a proven track record of high-quality science. Proficiency with in vivo methods such as administration of test articles, perfusion and tissue collection, blood collection, as well as rodent surgical models is required. Candidate level at hire will depend on education and experience. Responsibilities: Research Support * Conduct research on genetic metabolic diseases * Contribute to novel therapeutic programs based on innovative, ground-breaking discoveries that could lead to new, high-impact opportunities for patients * Perform research and publish findings in high-impact journals and present research at major conferences * Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan * Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums * Write, review and contribute to study synopses, protocols, study reports and regulatory documents * Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects * Participate in multi-disciplinary drug development teams and may lead sub-teams * Excellent written and verbal communication * Ability to build/foster productive cross-functional collaborations both within and external to BioMarin * Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice or rats, including health checks and documentation, willalso be required. * Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status including adverse study events. Meticulous electronic lab notebook documentation. * Communicate experimental plans and results to the project team. Support product development and regulatory filings for pivotal clinical studies. * Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines. * Share your knowledge and understanding with other team members * Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs. * Other duties as assigned. * Willingness to work on site full time including off hours and weekends based on study needs. * Other duties as assigned. General requirements for the position: * Demonstrated experience in metabolic biology/disease research in academia or industry (preferred) including publication record * Strong analytical, problem-solving, and decision-making skills * Strong understanding of genetically engineered models, breeding, and management and Gene therapy modalities * Excellent oral and written communication skills * Passion for contributing your scientific skills to develop therapies for patients in need * Must be able to utilize computer databases for analysis, data entry, and point of care observations * Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams * Must be able to work with external regulatory agencies and accreditation groups * Some "off-core business hours" work required * Complete all company training requirement * Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks * This position is an on-site critical required position * Other duties as assigned Education and Experience Requirements: * PhD in a related subject area with demonstrated in vivo research experience in metabolic disease * Postdoctoral or industry (2-5 years preferred) experience in genetic metabolic diseases * Extensive hands-on experience with rodent in vivo work in the metabolic field This position is full-time on-site and based in Petaluma, CA with occasional work on site in San Rafael, CA Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. The salary range for this position is: $116,000 to $159,500. BioMarin considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans. For additional benefits information, visit:

Description Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. We are seeking a motivated Scientist with experience in genetic metabolic diseases to join our team. The Scientist will join the Enzymatic and Metabolic In Vivo team to design and execute key in vivo studies focused on developing therapeutics to transform the lives of people with genetic metabolic disorders. This role reports into the In Vivo Lead. The primary role of the Scientist will be in design and execution of in vivo studies as part of the Enzymatic and Metabolic In Vivo Team. They will work collaboratively across the Research and Early Development Department to identify, develop and execute project strategies for in vivo testing of novel therapeutics. Areas of focus will span from animal model development to testing novel therapeutic approaches for genetic metabolic disorders. The successful candidate will have a strong background in metabolic and enzymatic biology, with demonstrated experience in the use of model systems in research. Experience with in vivo models of disease and a collaborative mindset is critical. While some industry experience is a plus, it is not required. The successful candidate will contribute in vivo model evaluation and support to project teams that support the project goals. Including in vivo study design, hands on in vivo study performance, selection and characterization of animal models, as well as application of in vivo methods and techniques. Strong written communication skills are critical for FDA filings, writing IACUC protocols, communicating scientific strategy, monitoring in vivo studies and collaborating with CRO's, tissue collection, and sample management. The successful candidate will also have experience with in vivo technical tasks including but not limited to dosing techniques (SC, IP, IV, RO, PO), blood collection (tail nick, saphenous vein puncture), and IVIS imaging. The ideal candidate will have Postdoctoral Academic or Biotech/Pharma industry in vivo experience in the metabolic disease field. The ideal candidate will have hands-on experience with animal models of metabolic/enzymatic disease, a proven track record of high-quality science. Proficiency with in vivo methods such as administration of test articles, perfusion and tissue collection, blood collection, as well as rodent surgical models is required. Candidate level at hire will depend on education and experience.Responsibilities: Research Support Conduct research on genetic metabolic diseases Contribute to novel therapeutic programs based on innovative, ground-breaking discoveries that could lead to new, high-impact opportunities for patients Perform research and publish findings in high-impact journals and present research at major conferences Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums Write, review and contribute to study synopses, protocols, study reports and regulatory documents Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects Participate in multi-disciplinary drug development teams and may lead sub-teams Excellent written and verbal communication Ability to build/foster productive cross-functional collaborations both within and external to BioMarin Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice or rats, including health checks and documentation, will also be required. Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status including adverse study events. Meticulous electronic lab notebook documentation. Communicate experimental plans and results to the project team. Support product development and regulatory filings for pivotal clinical studies. Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines. Share your knowledge and understanding with other team members Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs. Other duties as assigned. Willingness to work on site full time including off hours and weekends based on study needs. Other duties as assigned. General requirements for the position: Demonstrated experience in metabolic biology/disease research in academia or industry (preferred) including publication record Strong analytical, problem-solving, and decision-making skills Strong understanding of genetically engineered models, breeding, and management and Gene therapy modalities Excellent oral and written communication skills Passion for contributing your scientific skills to develop therapies for patients in need Must be able to utilize computer databases for analysis, data entry, and point of care observations Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams Must be able to work with external regulatory agencies and accreditation groups Some "off-core business hours" work required Complete all company training requirement Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks This position is an on-site critical required position Other duties as assigned Education and Experience Requirements: PhD in a related subject area with demonstrated in vivo research experience in metabolic disease Postdoctoral or industry (2-5 years preferred) experience in genetic metabolic diseases Extensive hands-on experience with rodent in vivo work in the metabolic field This position is full-time on-site and based in Petaluma, CA with occasional work on site in San Rafael, CA Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description We are seeking a highly talented and motivated Senior Oncology Bioinformatics Scientist to take a lead role in statistical analysis of multi-omics and next generation sequencing data to support research projects from target evaluation to biomarker discovery with a focus in immune oncology and cancer biology. The successful candidate will have the chance to work in a fast-paced and highly collaborative environment and impact high-level decision-making on internal pipeline and external collaboration. The scientist will be responsible for developing and employing rigorous statistical modeling and cutting-edge bioinformatics methods to perform integrative large scale omics dataset analysis to enable research objectives. The successful candidate will be able to formulate scientific questions into coherent analytical efforts and communicate analysis results and scientific findings to project teams and across different research functions. Essential Functions: Develop and apply statistical and computational tools to analyze large scale omics and high dimensional data from internal, publicly available, commercial, and real-world datasets to enable novel target identification, target assessment, MoA elucidation, drug combination rationale, and patient stratification, etc. Design and apply statistical techniques and machine learning algorithms to enable the discovery and evaluation of preclinical predictive and prognostic biomarkers for oncology projects. Collaborate with cross-functional teams to analyze and interpret complex large datasets and efficiently communicate findings to non-computational scientists and senior leaders. Minimum Knowledge, Experience, and Skills: Extensive hands-on experience in analyzing and interpreting RNA-Seq (bulk and single cell), WES, WGS, ATAC-Seq, CITE-Seq, and TCR-Seq data is required. The experience in analyzing other omics data (e.g., spatial transcriptome, Chip-Seq, MeRIP-seq, NanoString, multiplex qPCR, HT screening data sets) is a plus. Strong statistics knowledge, such as probability theory, univariate and multi-variable analysis, unsupervised and supervised analysis, regression analysis, survival analysis, feature selection, and power analysis. Excellent oral and written communication skills. Demonstrated capability to synthesize scientific questions into a coherent research effort and efficiently communicate scientific findings across different functional teams and present analysis results to project review teams and senior leader committees. A proactive and self-motivated scientist with a strong work ethic and scientific rigor; ability to work in a dynamic environment and manage multiple projects in parallel and adapt to changing priorities. Demonstrated track record of producing high-quality scientific results as an individual contributor and a team member. Basic Qualifications: Bachelor's Degree and Eight Years' Experience OR Masters' Degree and Six Years' Experience OR Ph.D. Preferred Qualifications: A PhD in bioinformatics, computational biology, biostatics, cancer genomics, or a related field with at least 3 years of relevant work experience. Industry experience is preferred. Excellent interpersonal and communication skills that foster collaboration and teamwork. Basic understanding of cancer biology, immunology, molecular and cell biology. Proficiency in R, Python, Perl, JAVA, or C/C++ programming languages. Proficiency in high performance computing and cloud computing environments. Outstanding track record of scientific and technical proficiency, evidenced by high quality publications in peer-reviewed journals. Able to work on-site at our Foster City Headquarters at least 3 days per week. People Leader Accountabilities Create Inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams. Develop Talent - understand the skills, experience, aspirations, and potential of their employees and coach them on current performance and future potential. They ensure employees are receiving the feedback and insight needed to grow, develop, and realize their purpose. Empower Teams - connect the team to the organization by aligning goals, purpose, and organizational objectives and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem. The salary range for this position is: $169,320.00 - $219,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. For jobs in the United States: Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. For Current Gilead Employees and Contractors: Please apply via the Internal Career Opportunities portal in Workday.

Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. We are seeking a Senior Scientist 1 - Biophysical Characterization & Bioconjugation to lead analytical strategy and experimental design for therapeutic proteins and their bioconjugates-particularly enzyme- and antibody-based platforms. You will join the Biologics Therapeutic Modality Team, developing advanced biophysical workflows, designing custom assays to define structure-function relationships, and guiding conjugation strategies for next-generation molecules. Your contributions will directly influence lead candidate selection, manufacturability, and regulatory readiness, helping advance promising therapies from bench to clinic. Key Responsibilities Strategic Leadership in Biophysical Characterization Lead biophysical characterization strategies for protein-based therapeutics (enzymes, antibodies, fusion proteins) and, as appropriate, other modalities such as nanoparticles and/or small molecules. Apply bioconjugation chemistry expertise to optimize critical product attributes such as half-life, specificity, and developability. Assay Development & Innovation Develop, optimize, and validate fit-for-purpose and high-throughput assays to assess higher-order structure, aggregation, stability, and binding interactions. For bioconjugates, evaluate conjugation efficiency, site occupancy, DAR/DPR, linker/payload stability, degradation profiles, and serum/matrix stability. Deliver well-documented, phase-appropriate analytical packages suitable for internal or CRO execution (development → qualification → transfer). Cross-Functional Collaboration Partner with Discovery, Therapeutic Development, Analytical Sciences, Protein Engineering, Formulation, and Regulatory teams to integrate biophysical insights and support decision-making at key development milestones. Technology Transfer & External Partnerships Lead technology transfer of assays and workflows to Analytical Sciences or external partners (CROs/CDMOs), ensuring SOP completeness, acceptance criteria, comparability plans, and data integrity standards. Scientific Innovation & External Engagement Stay current on bioconjugation and analytical biophysics innovations (e.g., mass photometry, HDX-MS, native/denaturing MS for DAR and site occupancy, FcRn assays). Evaluate and implement emerging platforms to strengthen data quality and reduce program risk. Regulatory Support Prepare analytical reports and datasets supporting IND/CTA submissions. Contribute to comparability assessments and respond to health authority queries in collaboration with CMC and Quality. Mentorship & Culture Building Act as a player-coach, mentoring junior scientists, maintaining high data integrity standards, and promoting a culture of excellence, innovation, and accountability. Qualifications Education: Ph.D. in Biophysics, Biochemistry, Pharmaceutical Sciences, or Chemical/Biomedical Engineering preferred. M.S. or B.S. with significant industry experience will be considered. Experience: Ph.D. with 6+ years, M.S. with 10+ years, or B.S. with 12+ years of relevant experience in biophysical and analytical characterization of biologics. Proven success with therapeutic protein conjugates (enzymes, antibodies, fusion proteins). Experience with small-molecule or nanoparticle conjugates is an advantage. Technical Expertise: Working knowledge or hands-on experience in at least one or two methods per category: Size/Assembly: SEC-MALS, FFF-MALS, AUC, DLS, Mass Photometry Structure/Stability: DSC, DSF, CD, FTIR, HDX-MS (preferred) Binding/Mechanism: SPR, BLI, ITC, MST Chromatography/Charge/Identity: HIC, IEX, RP-HPLC, CE-SDS, cIEF, LC-MS (intact mass, peptide mapping; native/denaturing for DAR/site occupancy) Conjugation Analytics: DAR/DPR analysis, linker/payload stability, forced degradation, serum/matrix stability Regulatory & CMC: Experience contributing to IND/CTA filings and supporting method lifecycle management for complex biologics and conjugates. Core Competencies Strong experimental design, quantitative analysis, and problem-solving skills Clear written and verbal communication Ability to lead and collaborate within cross-functional, matrixed teams Experience managing CRO/CDMO deliverables Preferred Qualifications Experience establishing release and stability testing panels for biologics or conjugates Demonstrated success transferring analytical methods to/from CROs/CDMOs, including full documentation and comparability packages Familiarity with regulatory submissions and agency interactions for bioconjugates or ADCs Evidence of scientific innovation, such as peer-reviewed publications, patents, or conference presentations Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

** **The Opportunity** The Department of Discovery Oncology at Genentech is excited to announce an opportunity for a Scientist, with a strong interdisciplinary background. In addition to deep expertise in oncology, cell biology and signaling, the ideal candidate will also have experience leveraging computational biology and novel machine-learning methods to enhance target identification and drug discovery. This position will be focused on new target discovery for oncology. The successful candidate will integrate efforts spanning the interface of functional genomics, molecular biology, and disease model engineering with computational methodologies. Working closely with our AI/ML group, drug development, translational medicine, and clinicians, you will help identify new therapeutic hypotheses and advance transformative medicines. **Key responsibilities include:** + Interdisciplinary Collaboration: Work closely with internal experts across computational and experimental disciplines to perform in silico, in vitro, in vivo, and ex vivo model systems that drive innovative therapeutic strategies. This will primarily be a wet-lab based position. + Innovative Drug Discovery: Leverage novel machine-learning methods and advanced computational tools to utilize multi-omics datasets, identify new targets, and refine drug discovery pipelines. + Translational Impact: Generate high-quality, original research that advances our understanding of cancer biology as well contributing to the development of new therapies for oncologic indications. **Who You Are** + Educational Background: Ph.D. in Biochemistry, Cell Biology, Computational Biology, or a closely related field. + Experience: 3 or more years relevant research experience. Your record should reflect high-impact publications and/or patents, and successful project transitions. + Technical Expertise: Demonstrated expertise in cell biology, cancer research, computational biology with exposure to/ leveraging AI/ ML, large data analysis for target discovery. + Experience in integrating functional genomics, molecular biology, and disease model engineering to drive drug discovery in oncology is essential. **Preferred** + Postdoctoral work is preferred but not required for exceptionally qualified graduate students If you are passionate about harnessing the power of advanced computational methodologies to uncover novel therapeutic targets for cancer and drive transformative medicines, we encourage you to apply. This role offers a unique opportunity to make a significant impact at the forefront of research and drug discovery at Genentech. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits (**************************************************** \#LI-KC2 \#gRED Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .

The Opportunity The Department of Discovery Oncology at Genentech is excited to announce an opportunity for a Scientist, with a strong interdisciplinary background. In addition to deep expertise in oncology, cell biology and signaling, the ideal candidate will also have experience leveraging computational biology and novel machine-learning methods to enhance target identification and drug discovery. This position will be focused on new target discovery for oncology. The successful candidate will integrate efforts spanning the interface of functional genomics, molecular biology, and disease model engineering with computational methodologies. Working closely with our AI/ML group, drug development, translational medicine, and clinicians, you will help identify new therapeutic hypotheses and advance transformative medicines. Key responsibilities include: * Interdisciplinary Collaboration: Work closely with internal experts across computational and experimental disciplines to perform in silico, in vitro, in vivo, and ex vivo model systems that drive innovative therapeutic strategies. This will primarily be a wet-lab based position. * Innovative Drug Discovery: Leverage novel machine-learning methods and advanced computational tools to utilize multi-omics datasets, identify new targets, and refine drug discovery pipelines. * Translational Impact: Generate high-quality, original research that advances our understanding of cancer biology as well contributing to the development of new therapies for oncologic indications. Who You Are * Educational Background: Ph.D. in Biochemistry, Cell Biology, Computational Biology, or a closely related field. * Experience: 3 or more years relevant research experience. Your record should reflect high-impact publications and/or patents, and successful project transitions. * Technical Expertise: Demonstrated expertise in cell biology, cancer research, computational biology with exposure to/ leveraging AI/ ML, large data analysis for target discovery. * Experience in integrating functional genomics, molecular biology, and disease model engineering to drive drug discovery in oncology is essential. Preferred * Postdoctoral work is preferred but not required for exceptionally qualified graduate students If you are passionate about harnessing the power of advanced computational methodologies to uncover novel therapeutic targets for cancer and drive transformative medicines, we encourage you to apply. This role offers a unique opportunity to make a significant impact at the forefront of research and drug discovery at Genentech. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits #LI-KC2 #gRED Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

The Opportunity The Department of Discovery Oncology at Genentech is excited to announce an opportunity for a Scientist, with a strong interdisciplinary background. In addition to deep expertise in oncology, cell biology and signaling, the ideal candidate will also have experience leveraging computational biology and novel machine-learning methods to enhance target identification and drug discovery. This position will be focused on new target discovery for oncology. The successful candidate will integrate efforts spanning the interface of functional genomics, molecular biology, and disease model engineering with computational methodologies. Working closely with our AI/ML group, drug development, translational medicine, and clinicians, you will help identify new therapeutic hypotheses and advance transformative medicines. Key responsibilities include: Interdisciplinary Collaboration: Work closely with internal experts across computational and experimental disciplines to perform in silico, in vitro, in vivo, and ex vivo model systems that drive innovative therapeutic strategies. This will primarily be a wet-lab based position. Innovative Drug Discovery: Leverage novel machine-learning methods and advanced computational tools to utilize multi-omics datasets, identify new targets, and refine drug discovery pipelines. Translational Impact: Generate high-quality, original research that advances our understanding of cancer biology as well contributing to the development of new therapies for oncologic indications. Who You Are Educational Background: Ph.D. in Biochemistry, Cell Biology, Computational Biology, or a closely related field. Experience: 3 or more years relevant research experience. Your record should reflect high-impact publications and/or patents, and successful project transitions. Technical Expertise: Demonstrated expertise in cell biology, cancer research, computational biology with exposure to/ leveraging AI/ ML, large data analysis for target discovery. Experience in integrating functional genomics, molecular biology, and disease model engineering to drive drug discovery in oncology is essential. Preferred Postdoctoral work is preferred but not required for exceptionally qualified graduate students If you are passionate about harnessing the power of advanced computational methodologies to uncover novel therapeutic targets for cancer and drive transformative medicines, we encourage you to apply. This role offers a unique opportunity to make a significant impact at the forefront of research and drug discovery at Genentech. Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits #LI-KC2 #gRED Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech, a member of the Roche Group. The Opportunity We have an exciting opportunity for an experienced scientific leader and medicinal chemist to join our Small Molecule Drug Discovery Chemistry Department at Genentech in South San Francisco, CA. The successful candidate will be responsible for leading drug discovery project teams through various stages of therapeutic target identification, druggability, preferred mode-of-action assessment, hit-finding enablement, hit-to-lead, and lead optimization in a multi-disciplinary, team-based culture. They will have particularly deep expertise in the early stages of drug discovery projects and would be working closely with therapeutic area leaders to evaluate potential targets. The position will entail responsibilities for influencing drug discovery practices and interacting directly with various functions such as Biochemical and Cellular Pharmacology, Drug Metabolism and Pharmacokinetics, Pharmaceutical Sciences, Safety Sciences, and Structural Biology. Who You Are * You will have a Ph.D. with 15+ years of medicinal chemistry experience in industry in the design and synthesis of analogs for molecular targets by applying state-of-the-art structure-driven and property-based design principles with deep experience in establishing and implementing successful partnerships with contract research organizations (CROs). * You will demonstrate a strong record of accomplishments as noted by significant and creative contributions to the success of small-molecule projects. * Lead, mentor, and provide career development for department staff and influence medicinal chemistry teams. * You will convey strong verbal and written communication skills and an ability to work collaboratively in teams. Preferred * Particular enthusiasm for mentoring colleagues across a wide range of experiences and disciplines is desired. The expected salary range for the Distinguished Scientist position based on the primary location of South San Francisco, CA is $196,100 - $364,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Relocation benefits are approved for this posting. #LI-KC2 Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

** A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. The Department of Cell and Tissue Genomics is seeking a creative, rigorous, and motivated Scientist 3 to develop and apply cutting-edge single cell genomic and epigenetic techniques to study cancer biology. The successful candidate will deploy these technologies to interrogate molecular mechanisms underlying disease states and identify candidate targets for therapeutic interventions. They will work in collaboration with colleagues in the departments of Research Oncology, Translational Medicine, and/or Computational Sciences. This is a hands-on position with both experimental and computational analysis components. **The Opportunity** + Develop and apply multimodal single-cell and epigenetic technologies in cell lines, disease models, and primary tissue samples + Analyze and interpret single-cell genomics and epigenetic sequencing data + Effectively collaborate with teams within the department and across Genentech + Communicate results through scientific publications and presentations + Contribute to identifying new research opportunities **Who You Are** + Doctorate degree in a relevant field, including molecular biology, cancer biology, genetics, immunology, systems biology, developmental biology, biochemistry, and/or biomedical engineering. Minimum of 4 years total academic and/or industry experience + Strong background in NGS assays, including epigenetic assays. + Experience with genomic/epigenomic data analyses and interpretation (R and/or Python) + Excellent oral and written presentation skills + Ability to manage multiple projects in parallel, collaborate with multidisciplinary teams, and lead research projects + Sustained record of productivity in the form of publications and patents. **Preferred** + Single cell genomic assay experience preferred. + Genomic technology development or optimization experience preferred + Experience with CRISPR genome editing and high throughput screens is a plus + Cancer biology or immunology expertise is a plus Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. **Benefits (****************************************************** Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. The Department of Cell and Tissue Genomics is seeking a creative, rigorous, and motivated Scientist 3 to develop and apply cutting-edge single cell genomic and epigenetic techniques to study cancer biology. The successful candidate will deploy these technologies to interrogate molecular mechanisms underlying disease states and identify candidate targets for therapeutic interventions. They will work in collaboration with colleagues in the departments of Research Oncology, Translational Medicine, and/or Computational Sciences. This is a hands-on position with both experimental and computational analysis components. The Opportunity * Develop and apply multimodal single-cell and epigenetic technologies in cell lines, disease models, and primary tissue samples * Analyze and interpret single-cell genomics and epigenetic sequencing data * Effectively collaborate with teams within the department and across Genentech * Communicate results through scientific publications and presentations * Contribute to identifying new research opportunities Who You Are * Doctorate degree in a relevant field, including molecular biology, cancer biology, genetics, immunology, systems biology, developmental biology, biochemistry, and/or biomedical engineering. Minimum of 4 years total academic and/or industry experience * Strong background in NGS assays, including epigenetic assays. * Experience with genomic/epigenomic data analyses and interpretation (R and/or Python) * Excellent oral and written presentation skills * Ability to manage multiple projects in parallel, collaborate with multidisciplinary teams, and lead research projects * Sustained record of productivity in the form of publications and patents. Preferred * Single cell genomic assay experience preferred. * Genomic technology development or optimization experience preferred * Experience with CRISPR genome editing and high throughput screens is a plus * Cancer biology or immunology expertise is a plus Relocation benefits are available for this posting. The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.