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Senior Research Fellow jobs at Genentech - 66 jobs

  • 2026 Summer Intern - Research Oncology

    Genentech 4.5company rating

    Senior research fellow job at Genentech

    ** **2026 Summer Intern - Research Oncology** The Research Oncology department serves as the engine of innovation within gRED (Genentech Research and Early Development). Our mission is simple yet audacious: to pursue groundbreaking science that transforms the standard of care for patients with the most complex cancers. This internship position is located in **South San Francisco, on-site.** **The Opportunity** + Literature search: Your goal is to identify "knowledge gaps" that our project can address, turning academic theory into actionable research hypotheses. + Mastery of Scientific Principles: You will work closely with your mentor to deeply understand the biological principles of our project. + Experimental Design & Optimization: You will actively design your own experiments. This includes calculating necessary concentrations, selecting appropriate controls and determining the most effective assays to answer specific biological questions. + Hands-on Bench Execution: You will lead the execution of your designed experiments in our state-of-the-art labs. + Data analysis & Presentation: You will analyze your findings, create professional-grade figures, and present your data during our group meetings. **Program Highlights** + **Intensive 12-weeks, full-time (40 hours per week) paid internship.** + **Program start dates are in May/June 2026.** + **A stipend, based on location, will be provided to help alleviate costs associated with the internship.** + Ownership of challenging and impactful business-critical projects. + Work with some of the most talented people in the biotechnology industry. **Who You Are** **Required Education: You meet one of the following criteria:** + Must be pursuing a Bachelor's Degree (enrolled student). + Must have attained a Bachelor's Degree (not currently enrolled in a graduate program). **Required Majors:** Biology, Molecular Biology, Immunology, Cell Biology. **Required Skills:** + Cell Culture: Maintaining and propagating various cell lines, including primary immune. + Mammalian Cell Culture. + Laboratory Rigor: pipetting, solution preparation, and documentation in electronic lab notebooks (ELN). + Ability to perform basic scientific calculations (molarity, dilutions) and statistical analyses to biological data. + Software Proficiency: Familiarity with data analysis tools such as Microsoft Excel, GraphPad Prism, or FlowJo. + Protein Analysis: (e.g., Western Blot, ELISA, or basic Flow Cytometry). **Preferred Knowledge, Skills, and Qualifications** + Excellent communication, collaboration, and interpersonal skills. + Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion. + Performing Peripheral Blood Mononuclear Cell (PBMC) isolation from blood samples and T cell isolation from PBMC. + Flow Cytometry: Preparing samples, running experiments on the flow cytometer, and performing basic data analysis for immunophenotyping and functional assays. **Relocation benefits are not available for this job posting.** The expected salary range for this position based on the primary location of California is $45.00 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .
    $45 hourly 9d ago
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  • 2026 Summer Intern - Discovery Chemistry - Analytical Research

    Genentech 4.5company rating

    Senior research fellow job at Genentech

    2026 Summer Intern - Discovery Chemistry - Analytical Research The Analytical Research group is part of the Discovery Chemistry department in the Drug Discovery organization. Our team focuses on developing structure elucidation, high-throughput purification, and physicochemical screening techniques to support the discovery and development of novel molecules. Our mission is to deliver high-quality analytical data that guide molecular design, process development, and quality control. We apply state-of-the-art techniques-including chromatography, mass spectrometry, and NMR spectroscopy-to elucidate chemical structures, reaction mechanisms, and stability profiles. We are passionate about scientific rigor, innovation, and cross-functional collaboration to bring transformative medicines to patients. This internship position is located in South San Francisco, on-site. The Opportunity * Contribute to the development of real-time analytical strategies for macrocyclic peptides. * The project focuses on applying machine learning to analytical chromatography to help enable preparative separation. * Develop and optimize analytical methods (HPLC, LC-MS, UV-Vis) for peptides. * Develop a machine learning model to predict optimal separation conditions. * Summarize and present experimental findings to multidisciplinary teams. * This internship offers hands-on experience with advanced analytical instrumentation and exposure to a cross-functional research environment focused on next-generation therapeutic modalities. Program Highlights * Intensive 12-weeks, full-time (40 hours per week) paid internship. * Program start dates are in May/June 2026. * A stipend, based on location, will be provided to help alleviate costs associated with the internship. * Ownership of challenging and impactful business-critical projects. * Work with some of the most talented people in the biotechnology industry. Who You Are Required Education: Must be pursuing a Bachelor's Degree (enrolled student). Required Majors: Chemistry, Biochemistry, Pharmaceutical Chemistry, or a related field. Required Skills: * Foundational knowledge and experience of organic chemistry. * Basic understanding and hands-on experience in chromatography (HPLC/LC-MS) and spectroscopy (UV-Vis). * Mass Spectrometry. * Proficiency in Python. * Strong experimental and data interpretation skills. * Enthusiasm for problem solving and innovation in analytical chemistry. Preferred Knowledge, Skills, and Qualifications * Experience with deep learning frameworks (e.g. PyTorch). * Experience operating or interpreting data from HPLC or LC-MS. * Prior laboratory experience. * Proficiency with literature search. * Excellent communication, collaboration, and interpersonal skills. * Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion. Relocation benefits are not available for this job posting. The expected salary range for this position based on the primary location of California is $45.00 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
    $45 hourly 7d ago
  • Postdoctoral Scientist (HIV CURE)

    Gilead Sciences, Inc. 4.5company rating

    Foster City, CA jobs

    At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. **Job Description** The Virology group is seeking a highly motivated Postdoc to join our team at Gilead Sciences in Foster City, CA. This Post-Doctoral position offers a unique opportunity to investigate a central challenge in HIV cure research: understanding why only a subset of intact HIV proviruses are transcriptionally active or inducible, while others remain persistently silent. The fellow will lead a mechanistic study at single-provirus resolution, leveraging advanced molecular and cellular assays to dissect the viral, host, and epigenetic factors that shape proviral expression and reservoir behavior. By systematically characterizing how different stimuli modulate the transcriptional landscape of the reservoir, this research will generate foundational insights into the determinants of proviral activity and persistence, informing future therapeutic strategies aimed at durable HIV remission. The candidate will work closely with scientists in the Virology group and collaborators from our sequencing core and bioinformatics teams. They are expected to develop independence in experimental design, execution, and interpretation. The fellow will actively participate in group meetings and present experimental approaches and results at relevant internal & external forums. The fellow will be encouraged to publish their work in top tier journals and present at international scientific conferences. Organizational skills in data management and molecular assay development are essential. A PhD is required in a relevant scientific discipline, such as molecular virology, immunology, or cell biology. A strong record of scientific excellence, as evidenced by publications in peer-reviewed journals, is highly desirable. Excellent verbal and written communication skills and interpersonal skills are required. The candidate must demonstrate high scientific curiosity and motivation, as well as the ability to work effectively in a collaborative research environment. Technical excellence, familiarity with HIV molecular biology, and independent thought in evaluating experimental design and strategy are key attributes. **Job Responsibilities** + Conducts scientific research to advance understanding of HIV latency and reservoir dynamics. + Applies principles and techniques of molecular virology and immunology to investigate latency reversal mechanisms. + Works under supervision of senior scientists to develop and optimize assays for proviral quantification, transcriptional profiling, and integration site mapping. + Designs and implements experiments using primary CD4+ T cells from ART-suppressed individuals to evaluate transcriptional responses to relevant stimuli + Collaborates with internal and external teams to integrate sequencing, flow cytometry, and single-cell transcriptomics. + May advise research associates or project team members in the initiation and execution of laboratory experiments. **Basic Qualifications** + PhD in molecular virology, immunology, cell biology, or a related scientific discipline is required. + Ability to develop methods, techniques, and evaluation criteria for obtaining results. + Technical proficiency, scientific creativity, collaboration with others, and independent thought in suggesting experimental design and research strategy. + Strong verbal communication and interpersonal skills. + Must be able to participate in highly effective teams. **Preferred Qualifications** + Experience with HIV molecular assays (e.g., IPDA, CA-RNA, near full-length sequencing) and primary cell culture preferred. The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may be eligible for paid time off and a benefits package. Benefits MAY include company-sponsored medical, dental, vision, and life insurance plans*. This position is not eligible for a discretionary annual bonus or discretionary stock-based long-term incentives. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. **For jobs in the United States:** Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' (********************************************** poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT (********************************************************* YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. **For Current Gilead Employees and Contractors:** Please apply via the Internal Career Opportunities portal in Workday. Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.
    $126.8k-164.1k yearly 60d+ ago
  • Postdoctoral Scientist - Human Cell Cycle

    Gilead Sciences 4.5company rating

    Foster City, CA jobs

    At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description The Research Oncology group is seeking a highly motivated Post-Doctoral Scientist to elucidate fundamental cell cycle mechanisms that underlie tumor cell dependencies. Responsibilities: The successful candidate will initiate and lead an independent research project to discover novel mechanisms that control the cell cycle under steady-state conditions and following pharmacological perturbations, elucidating how key cell cycle proteins interact to direct the cell cycle in cancer. This fundamental research will dovetail with drug development programs, and the new pharmacological interventions that emerge, to enable unprecedented views into critical workings of early cell cycle transitions. Work with co-mentors to identify key questions in cancer cell cycle biology and independently draft research plans to answer these questions. Independently execute experiments, analyze data, and review results with co-mentors and the larger research community. Publish impactful findings in top-tier journals and present at scientific conferences. The selected candidate will work in a highly collaborative environment at Gilead through a 3-year fixed term, with access to world-class research facilities and the opportunity to leverage expertise and resources across multiple functional areas. Basic Qualifications: Ph.D. (awarded or to be awarded within the next 6 months) in molecular biology, biochemistry, cancer biology or related field. First-author publication(s) in peer-reviewed journals. Think critically and creatively to independently design, execute, analyze, and communicate rigorous experimentation. Experience with cancer cell biology, biochemical methods and molecular biology desired. Preferred Qualifications: Familiarity and hands on experience with the human cell cycle Expertise in molecular biology, microscopy, CRISPR/Cas9, and omics-based approaches The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may be eligible for paid time off and a benefits package. Benefits MAY include company-sponsored medical, dental, vision, and life insurance plans*. This position is not eligible for a discretionary annual bonus or discretionary stock-based long-term incentives. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. For jobs in the United States: Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. For Current Gilead Employees and Contractors: Please apply via the Internal Career Opportunities portal in Workday.
    $126.8k-164.1k yearly Auto-Apply 11d ago
  • Postdoctoral Scientist (Computational & Structural Bioinformatics)

    Gilead Sciences 4.5company rating

    Foster City, CA jobs

    At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description Location: Foster City, CA Term: 3-Year Fixed Term About the Role Join a pioneering team at the forefront of computational and structural biology, driving innovation to transform therapeutic discovery. We are seeking an exceptional Postdoctoral Scientist to lead research focused on predicting and optimizing protein-protein interactions using cutting-edge approaches that combine physics-based modeling, machine learning, and experimental validation, advancing the design of next-generation proteins and antibodies. This position is a joint appointment between Research Data Sciences and Protein Therapeutics, providing a unique opportunity for cross-functional collaboration and exposure to diverse expertise. As a Postdoctoral Scientist, you will have the freedom to design and lead an independent research project, publish in high-impact journals, and work alongside world-class scientists across computational and experimental disciplines. Your contributions will directly shape the future of biologics and antibody therapeutics. What You'll Do Develop advanced computational workflows for protein modeling, structural analysis, and molecular simulations. Apply machine learning and physics-based approaches to predict and optimize protein-protein interactions. Analyze large-scale biological datasets to uncover insights that guide experimental design. Validate computational predictions and generate critical training datasets in the lab. Optimize automated cloud-based pipelines for large-scale predictions and data processing. Publish and present your findings at top-tier conferences and journals. Basic Qualifications Ph.D. in Computational Biology, Bioinformatics, Structural Biology, Biophysics, or related fields. At least one first-author publication in a peer-reviewed journal. Strong Python programming skills with extensive experience using scientific libraries (e.g., NumPy, SciPy, pandas) and deep learning frameworks including PyTorch and TensorFlow. Expertise in protein modeling tools (AlphaFold, RFDiffusion, Rosetta, PyMOL, etc) Hands-on experience with molecular dynamics packages (AMBER, GROMACS, etc) is a plus. Familiarity with antibody structure and protein engineering principles. Proficiency in Linux environments and deploying workflows on HPC clusters. Excellent problem-solving and communication skills. Preferred Qualifications (one or more of the following) Experience with graph neural networks, diffusion models, or generative frameworks for antibody design and optimization. Knowledge of enhanced sampling techniques (Metadynamics, Umbrella sampling). Understanding binding thermodynamics and free energy calculations. Experience and/or familiarity with approaches for affinity validation and screening in the lab (e.g. high throughput recombinant protein production, ELISA, SPR/BLI, flow cytometry, display technologies, NGS) - training provided as needed. The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may be eligible for paid time off and a benefits package. Benefits MAY include company-sponsored medical, dental, vision, and life insurance plans*. This position is not eligible for a discretionary annual bonus or discretionary stock-based long-term incentives. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. For jobs in the United States: Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. For Current Gilead Employees and Contractors: Please apply via the Internal Career Opportunities portal in Workday.
    $126.8k-164.1k yearly Auto-Apply 60d+ ago
  • Postdoctoral Scientist - Fibrosis, Liver Disease

    Gilead Sciences 4.5company rating

    Foster City, CA jobs

    At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description The Inflammation Biology group is seeking a passionate and driven Postdoctoral Scientist to pursue innovative research at the forefront of chronic fibrotic liver disease. This role offers a unique opportunity to explore the complex biology of conditions such as metabolic dysfunction-associated steatohepatitis (MASH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). The successful candidate will spearhead an independent research project focused on uncovering novel pathogenic mechanisms and identifying therapeutic targets in chronic fibrotic diseases. This work is expected to yield impactful insights into the pathogenesis of human disease and high-impact publications in leading scientific journals. This is a three-year postdoctoral training position at Gilead. The role is embedded in a highly collaborative and resource-rich environment, offering access to world-class facilities and cross-functional expertise across Gilead's research ecosystem. Responsibilities: The successful candidate will initiate and lead independent research projects to investigate pathogenic mechanisms in chronic fibrotic liver disease They will utilize Gilead's rich single cell and spatial transcriptomic datasets as well as clinical datasets to uncover novel mechanisms driving fibrotic niche expansion The candidate will use a combination of mouse genetic and pharmacology approaches to investigate key disease drivers and establish novel ex vivo models allowing for target identification and screening With the support of a mentor, the postdoctoral scientist will design, conduct, and analyze in vitro and in vivo experiments to drive research towards publication in a top-tier journal. The postdoctoral scientist will be expected to publish their work in top-tier journals and present at scientific conferences. The selected candidate will work in a highly collaborative environment at Gilead through a three-year fixed term, with access to world-class research facilities and the opportunity to leverage expertise and resources across multiple functional areas. Basic Qualifications: Ph.D. in biochemistry, molecular biology, immunology or related discipline. At least one first author paper published or accepted in a peer-reviewed journal. Proficiency in mammalian cell biology and biochemistry techniques. Excellent written, verbal, and interpersonal communication skills and strong organizational skills are required. Preferred Qualifications: Preference will be given to candidates with broad hands-on expertise in cell biology, molecular biology, biochemistry and imaging techniques including in vitro cell-based functional assays, primary cell cultures, transfection/transduction techniques, CRISPR/Cas9, microscopy, flow cytometry, and other immunoassays. Hands-on experience with mouse models of disease, mouse handling, in-life procedures and tissue harvesting are preferred. Familiarity with the analysis of large-scale multiomic datasets, such as single-cell and spatial transcriptomics, is preferred. Experience developing complex primary cell co-culture systems is an advantage. The individual should have demonstrable skills and experience in leading focused hypothesis-driven biological research, as exemplified by quality publications. The successful candidate must have demonstrated success in working in a cross-functional and highly collaborative team environment, and must be able to communicate clearly and effectively, both verbally and in writing, to a variety of audiences. The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may be eligible for paid time off and a benefits package. Benefits MAY include company-sponsored medical, dental, vision, and life insurance plans*. This position is not eligible for a discretionary annual bonus or discretionary stock-based long-term incentives. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. For jobs in the United States: Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. For Current Gilead Employees and Contractors: Please apply via the Internal Career Opportunities portal in Workday.
    $126.8k-164.1k yearly Auto-Apply 11d ago
  • Postdoctoral Scientist (HIV CURE)

    Gilead Sciences 4.5company rating

    Foster City, CA jobs

    At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description The Virology group is seeking a highly motivated Postdoc to join our team at Gilead Sciences in Foster City, CA. This Post-Doctoral position offers a unique opportunity to investigate a central challenge in HIV cure research: understanding why only a subset of intact HIV proviruses are transcriptionally active or inducible, while others remain persistently silent. The fellow will lead a mechanistic study at single-provirus resolution, leveraging advanced molecular and cellular assays to dissect the viral, host, and epigenetic factors that shape proviral expression and reservoir behavior. By systematically characterizing how different stimuli modulate the transcriptional landscape of the reservoir, this research will generate foundational insights into the determinants of proviral activity and persistence, informing future therapeutic strategies aimed at durable HIV remission. The candidate will work closely with scientists in the Virology group and collaborators from our sequencing core and bioinformatics teams. They are expected to develop independence in experimental design, execution, and interpretation. The fellow will actively participate in group meetings and present experimental approaches and results at relevant internal & external forums. The fellow will be encouraged to publish their work in top tier journals and present at international scientific conferences. Organizational skills in data management and molecular assay development are essential. A PhD is required in a relevant scientific discipline, such as molecular virology, immunology, or cell biology. A strong record of scientific excellence, as evidenced by publications in peer-reviewed journals, is highly desirable. Excellent verbal and written communication skills and interpersonal skills are required. The candidate must demonstrate high scientific curiosity and motivation, as well as the ability to work effectively in a collaborative research environment. Technical excellence, familiarity with HIV molecular biology, and independent thought in evaluating experimental design and strategy are key attributes. Job Responsibilities Conducts scientific research to advance understanding of HIV latency and reservoir dynamics. Applies principles and techniques of molecular virology and immunology to investigate latency reversal mechanisms. Works under supervision of senior scientists to develop and optimize assays for proviral quantification, transcriptional profiling, and integration site mapping. Designs and implements experiments using primary CD4+ T cells from ART-suppressed individuals to evaluate transcriptional responses to relevant stimuli Collaborates with internal and external teams to integrate sequencing, flow cytometry, and single-cell transcriptomics. May advise research associates or project team members in the initiation and execution of laboratory experiments. Basic Qualifications PhD in molecular virology, immunology, cell biology, or a related scientific discipline is required. Ability to develop methods, techniques, and evaluation criteria for obtaining results. Technical proficiency, scientific creativity, collaboration with others, and independent thought in suggesting experimental design and research strategy. Strong verbal communication and interpersonal skills. Must be able to participate in highly effective teams. Preferred Qualifications Experience with HIV molecular assays (e.g., IPDA, CA-RNA, near full-length sequencing) and primary cell culture preferred. The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may be eligible for paid time off and a benefits package. Benefits MAY include company-sponsored medical, dental, vision, and life insurance plans*. This position is not eligible for a discretionary annual bonus or discretionary stock-based long-term incentives. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. For jobs in the United States: Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. For Current Gilead Employees and Contractors: Please apply via the Internal Career Opportunities portal in Workday.
    $126.8k-164.1k yearly Auto-Apply 11d ago
  • Postdoctoral Scientist (Computational & Structural Bioinformatics)

    Gilead Sciences, Inc. 4.5company rating

    Foster City, CA jobs

    At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description Location: Foster City, CA Term: 3-Year Fixed Term About the Role Join a pioneering team at the forefront of computational and structural biology, driving innovation to transform therapeutic discovery. We are seeking an exceptional Postdoctoral Scientist to lead research focused on predicting and optimizing protein-protein interactions using cutting-edge approaches that combine physics-based modeling, machine learning, and experimental validation, advancing the design of next-generation proteins and antibodies. This position is a joint appointment between Research Data Sciences and Protein Therapeutics, providing a unique opportunity for cross-functional collaboration and exposure to diverse expertise. As a Postdoctoral Scientist, you will have the freedom to design and lead an independent research project, publish in high-impact journals, and work alongside world-class scientists across computational and experimental disciplines. Your contributions will directly shape the future of biologics and antibody therapeutics. What You'll Do * Develop advanced computational workflows for protein modeling, structural analysis, and molecular simulations. * Apply machine learning and physics-based approaches to predict and optimize protein-protein interactions. * Analyze large-scale biological datasets to uncover insights that guide experimental design. * Validate computational predictions and generate critical training datasets in the lab. * Optimize automated cloud-based pipelines for large-scale predictions and data processing. * Publish and present your findings at top-tier conferences and journals. Basic Qualifications * Ph.D. in Computational Biology, Bioinformatics, Structural Biology, Biophysics, or related fields. * At least one first-author publication in a peer-reviewed journal. * Strong Python programming skills with extensive experience using scientific libraries (e.g., NumPy, SciPy, pandas) and deep learning frameworks including PyTorch and TensorFlow. * Expertise in protein modeling tools (AlphaFold, RFDiffusion, Rosetta, PyMOL, etc) * Hands-on experience with molecular dynamics packages (AMBER, GROMACS, etc) is a plus. * Familiarity with antibody structure and protein engineering principles. * Proficiency in Linux environments and deploying workflows on HPC clusters. * Excellent problem-solving and communication skills. Preferred Qualifications (one or more of the following) * Experience with graph neural networks, diffusion models, or generative frameworks for antibody design and optimization. * Knowledge of enhanced sampling techniques (Metadynamics, Umbrella sampling). * Understanding binding thermodynamics and free energy calculations. * Experience and/or familiarity with approaches for affinity validation and screening in the lab (e.g. high throughput recombinant protein production, ELISA, SPR/BLI, flow cytometry, display technologies, NGS) - training provided as needed. The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may be eligible for paid time off and a benefits package. Benefits MAY include company-sponsored medical, dental, vision, and life insurance plans*. This position is not eligible for a discretionary annual bonus or discretionary stock-based long-term incentives. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. For jobs in the United States: Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. For Current Gilead Employees and Contractors: Please apply via the Internal Career Opportunities portal in Workday.
    $126.8k-164.1k yearly Auto-Apply 60d+ ago
  • Postdoctoral Scientist - Fibrosis, Liver Disease

    Gilead Sciences, Inc. 4.5company rating

    Foster City, CA jobs

    At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description The Inflammation Biology group is seeking a passionate and driven Postdoctoral Scientist to pursue innovative research at the forefront of chronic fibrotic liver disease. This role offers a unique opportunity to explore the complex biology of conditions such as metabolic dysfunction-associated steatohepatitis (MASH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). The successful candidate will spearhead an independent research project focused on uncovering novel pathogenic mechanisms and identifying therapeutic targets in chronic fibrotic diseases. This work is expected to yield impactful insights into the pathogenesis of human disease and high-impact publications in leading scientific journals. This is a three-year postdoctoral training position at Gilead. The role is embedded in a highly collaborative and resource-rich environment, offering access to world-class facilities and cross-functional expertise across Gilead's research ecosystem. Responsibilities: * The successful candidate will initiate and lead independent research projects to investigate pathogenic mechanisms in chronic fibrotic liver disease * They will utilize Gilead's rich single cell and spatial transcriptomic datasets as well as clinical datasets to uncover novel mechanisms driving fibrotic niche expansion * The candidate will use a combination of mouse genetic and pharmacology approaches to investigate key disease drivers and establish novel ex vivo models allowing for target identification and screening * With the support of a mentor, the postdoctoral scientist will design, conduct, and analyze in vitro and in vivo experiments to drive research towards publication in a top-tier journal. The postdoctoral scientist will be expected to publish their work in top-tier journals and present at scientific conferences. The selected candidate will work in a highly collaborative environment at Gilead through a three-year fixed term, with access to world-class research facilities and the opportunity to leverage expertise and resources across multiple functional areas. Basic Qualifications: * Ph.D. in biochemistry, molecular biology, immunology or related discipline. * At least one first author paper published or accepted in a peer-reviewed journal. * Proficiency in mammalian cell biology and biochemistry techniques. * Excellent written, verbal, and interpersonal communication skills and strong organizational skills are required. Preferred Qualifications: * Preference will be given to candidates with broad hands-on expertise in cell biology, molecular biology, biochemistry and imaging techniques including in vitro cell-based functional assays, primary cell cultures, transfection/transduction techniques, CRISPR/Cas9, microscopy, flow cytometry, and other immunoassays. * Hands-on experience with mouse models of disease, mouse handling, in-life procedures and tissue harvesting are preferred. * Familiarity with the analysis of large-scale multiomic datasets, such as single-cell and spatial transcriptomics, is preferred. * Experience developing complex primary cell co-culture systems is an advantage. * The individual should have demonstrable skills and experience in leading focused hypothesis-driven biological research, as exemplified by quality publications. * The successful candidate must have demonstrated success in working in a cross-functional and highly collaborative team environment, and must be able to communicate clearly and effectively, both verbally and in writing, to a variety of audiences. The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may be eligible for paid time off and a benefits package. Benefits MAY include company-sponsored medical, dental, vision, and life insurance plans*. This position is not eligible for a discretionary annual bonus or discretionary stock-based long-term incentives. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. For jobs in the United States: Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. For Current Gilead Employees and Contractors: Please apply via the Internal Career Opportunities portal in Workday.
    $126.8k-164.1k yearly Auto-Apply 49d ago
  • Postdoctoral Scientist (Computational & Structural Bioinformatics)

    Gilead Sciences, Inc. 4.5company rating

    Foster City, CA jobs

    At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. **Job Description** **Location:** Foster City, CA **Term:** 3-Year Fixed Term **About the Role** Join a pioneering team at the forefront of computational and structural biology, driving innovation to transform therapeutic discovery. We are seeking an exceptional **Postdoctoral Scientist** to lead research focused on predicting and optimizing protein-protein interactions using cutting-edge approaches that combine physics-based modeling, machine learning, and experimental validation, advancing the design of next-generation proteins and antibodies. This position is a joint appointment between Research Data Sciences and Protein Therapeutics, providing a unique opportunity for cross-functional collaboration and exposure to diverse expertise. As a Postdoctoral Scientist, you will have the freedom to design and lead an independent research project, publish in high-impact journals, and work alongside world-class scientists across computational and experimental disciplines. Your contributions will directly shape the future of biologics and antibody therapeutics. **What** **You'll** **Do** + Develop advanced computational workflows for protein modeling, structural analysis, and molecular simulations. + Apply machine learning and physics-based approaches to predict and optimize protein-protein interactions. + Analyze large-scale biological datasets to uncover insights that guide experimental design. + Validate computational predictions and generate critical training datasets in the lab. + Optimizeautomated cloud-based pipelines for large-scale predictions and data processing. + Publish and present your findings at top-tier conferences and journals. **Basic Qualifications** + Ph.D. in Computational Biology, Bioinformatics, Structural Biology, Biophysics, or related fields. + At least one first-author publication in a peer-reviewed journal. + Strong Python programming skills with extensive experience using scientific libraries (e.g., NumPy, SciPy, pandas) and deep learning frameworks including PyTorch and TensorFlow. + Expertise in protein modeling tools (AlphaFold, RFDiffusion, Rosetta, PyMOL, etc) + Hands-on experience with molecular dynamics packages (AMBER, GROMACS, etc) is a plus. + Familiarity with antibody structure and protein engineering principles. + Proficiency in Linux environments and deploying workflows on HPC clusters. + Excellent problem-solving and communication skills. **Preferred Qualifications** **(one** **or more** **of the following)** + Experience with graph neural networks, diffusion models, or generative frameworks for antibody design and optimization. + Knowledge of enhanced sampling techniques (Metadynamics, Umbrella sampling). + Understanding binding thermodynamics and free energy calculations. + Experience and/or familiaritywithapproaches for affinity validation and screening in the lab (e.g. high throughput recombinant protein production, ELISA, SPR/BLI, flow cytometry, display technologies, NGS) - training provided as needed. The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may be eligible for paid time off and a benefits package. Benefits MAY include company-sponsored medical, dental, vision, and life insurance plans*. This position is not eligible for a discretionary annual bonus or discretionary stock-based long-term incentives. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. **For jobs in the United States:** Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' (********************************************** poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT (********************************************************* YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. **For Current Gilead Employees and Contractors:** Please apply via the Internal Career Opportunities portal in Workday. Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.
    $126.8k-164.1k yearly 60d+ ago
  • Postdoctoral Scientist - Fibrosis, Liver Disease

    Gilead Sciences, Inc. 4.5company rating

    Foster City, CA jobs

    At Gilead, we're creating a healthier world for all people. For more than 35 years, we've tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer - working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world's biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead's team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we're looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. **Job Description** The Inflammation Biology group is seeking a passionate and driven **Postdoctoral Scientist** to pursue innovative research at the forefront of chronic fibrotic liver disease. This role offers a unique opportunity to explore the complex biology of conditions such as metabolic dysfunction-associated steatohepatitis (MASH), primary biliary **cholangitis** (PBC), and **primary sclerosing cholangitis** (PSC). The successful candidate will spearhead an independent research project focused on uncovering novel pathogenic mechanisms and identifying therapeutic targets in chronic fibrotic diseases. This work is expected to yield impactful insights into the pathogenesis of human disease and high-impact publications in leading scientific journals. This is a three-year postdoctoral training position at Gilead. The role is embedded in a highly collaborative and resource-rich environment, offering access to world-class facilities and cross-functional expertise across Gilead's research ecosystem. **Responsibilities:** + The successful candidate will initiate and lead independent research projects to investigate pathogenic mechanisms in chronic fibrotic liver disease + They will utilize Gilead's rich single cell and spatial transcriptomic datasets as well as clinical datasets to uncover novel mechanisms driving fibrotic niche expansion + The candidate will use a combination of mouse genetic and pharmacology approaches to investigate key disease drivers and establish novel ex vivo models allowing for target identification and screening + With the support of a mentor, the postdoctoral scientist will design, conduct, and analyze in vitro and in vivo experiments to drive research towards publication in a top-tier journal. The postdoctoral scientist will be expected to publish their work in top-tier journals and present at scientific conferences. The selected candidate will work in a highly collaborative environment at Gilead through a three-year fixed term, with access to world-class research facilities and the opportunity to leverage expertise and resources across multiple functional areas. Basic Qualifications: + Ph.D. in biochemistry, molecular biology, immunology or related discipline. + At least one first author paper published or accepted in a peer-reviewed journal. + Proficiency in mammalian cell biology and biochemistry techniques. + Excellent written, verbal, and interpersonal communication skills and strong organizational skills are required. Preferred Qualifications: + Preference will be given to candidates with broad hands-on expertise in cell biology, molecular biology, biochemistry and imaging techniques including in vitro cell-based functional assays, primary cell cultures, transfection/transduction techniques, CRISPR/Cas9, microscopy, flow cytometry, and other immunoassays. + Hands-on experience with mouse models of disease, mouse handling, in-life procedures and tissue harvesting are preferred. + Familiarity with the analysis of large-scale multiomic datasets, such as single-cell and spatial transcriptomics, is preferred. + Experience developing complex primary cell co-culture systems is an advantage. + The individual should have demonstrable skills and experience in leading focused hypothesis-driven biological research, as exemplified by quality publications. + The successful candidate must have demonstrated success in working in a cross-functional and highly collaborative team environment, and must be able to communicate clearly and effectively, both verbally and in writing, to a variety of audiences. The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may be eligible for paid time off and a benefits package. Benefits MAY include company-sponsored medical, dental, vision, and life insurance plans*. This position is not eligible for a discretionary annual bonus or discretionary stock-based long-term incentives. For additional benefits information, visit: ****************************************************************** * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. **For jobs in the United States:** Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' (********************************************** poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT (********************************************************* YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. **For Current Gilead Employees and Contractors:** Please apply via the Internal Career Opportunities portal in Workday. Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.
    $126.8k-164.1k yearly 60d+ ago
  • Intern, Skeletal Analytical Research

    Biomarin Pharmaceutical Inc. 4.6company rating

    San Rafael, CA jobs

    Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. SUMMARY: The BioMarin Summer Internship Program will enable students to gain valuable experience and knowledge of the processes and systems within BioMarin, while gaining an insight into the pharmaceutical/biotech industry. Over the course of 10 - 12 weeks our interns gain industry experience while working alongside our talented team on meaningful projects. BioMarin's Research & Development (R&D) group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients' lives. Within R&D, we have an opening for a motivated Summer Intern to join our Skeletal and CNP Therapeutic Area Analytical Group. This internship offers a unique opportunity to gain hands-on experience by working on a laboratory-based project that supports and contributes to drug development. JOB DESCRIPTION/PROJECT: * Work closely with a scientist on a dedicated research project * Gain practical experience in molecular biology, analytical and biochemical assays * Apply laboratory techniques, which may include immunoassays, microscopy, imaging, PCR/qPCR, immunohistochemistry (IHC), immunofluorescence (IF), and other staining techniques * Design, conduct, and interpret experiments * Present project updates at group meetings and project summary to the broader department at the end of the summer. Responsibilities * Conduct bench experiments under the guidance of a scientist mentor * Apply techniques such as immunoassays, microscopy and imaging, PCR/qPCR, IHC, IF, and other analytical techniques * Maintain detailed records of experimental design, procedures, and results in electronic laboratory notebooks. * Participate in group discussions and present project updates, including a final project summary to the broader department at the end of summer. Theoretical knowledge: * Microscopy and imaging techniques * Immunohistochemistry (IHC), immunofluorescence (IF), and other analytical techniques * Mammalian cell culture * PCR/qPCR * Immunoassays * Other molecular and biochemical assays Qualifications/Eligibility: * Student pursuing a bachelor's degree in scientific discipline * Must be returning to school in the Fall Term OR has graduated within the 1 year of the start of the program. * Must be available to work full time, 40 hours a week. * Must be currently enrolled as a full-time student at an accredited U.S. based university or college and enrolled in the fall term after the completion of the internship OR have graduated within 1 year of the start of the program. * Must be able to relocate if necessary and work at the designated site for the duration of the internship for on-site, hybrid roles. Benefits of a BioMarin Internship: * Paid hourly wage, paid company holidays, and sick time * Apply skills and knowledge learned in the classroom to on-the-job experiences * Comprehensive, value-added project(s) * Develop skills specific to your major. * Opportunities for professional development by building relationships and learning about other parts of the business. * Participate in company all hands meetings, monthly community lunches * Corporate office amenities such as: 24/7 on-site gym, coffee truck, snacks * Access to Employee Resource Groups Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. In the U.S., the salary range for this position is
    $70k-97k yearly est. 49d ago
  • Intern, Skeletal Cell Biology Research

    Biomarin Pharmaceutical 4.6company rating

    San Rafael, CA jobs

    Description Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. SUMMARY:The BioMarin Summer Internship Program will enable students to gain valuable experience and knowledge of the processes and systems within BioMarin, while gaining an insight into the pharmaceutical/biotech industry. Over the course of 10 - 12 weeks our interns gain industry experience while working alongside our talented team on meaningful projects. BioMarin's Research and Early Development (RED) team focuses on discovering and advancing innovative therapies for rare genetic conditions. We work across multiple scientific disciplines to translate early research into potential treatments that can make a meaningful impact for patients. The Skeletal Therapeutic Area is dedicated to developing therapies aimed at improving outcomes for individuals with skeletal conditions. Interns will gain exposure to research techniques, contribute meaningful work to support active research programs, and learn how early-stage drug development happens in a collaborative environment. JOB DESCRIPTION/PROJECT:Develop reporter cell lines to monitor gene regulation in response to treatments that alter signaling pathways. Incorporate clinically relevant genetic variants into these models to study their impact on RNA processing and stability, including evaluation of cellular RNA quality-control mechanisms. Required Skills: Hands-on experience working in a mammalian cell culture lab, including aseptic techniques Basic understanding of RNA biology Ability to follow protocols and standard operating procedures with precision Strong organizational skills and commitment to accurate record-keeping A proactive, collaborative attitude with a willingness to learn new scientific techniques Desired Skills: Experience with qPCR or dd PCR for gene expression analysis Familiarity with Western blot or ELISA for protein-level studies Ability to analyze and visualize data using graphing or statistical software Qualifications/Eligibility: Undergraduate student in their 3 rd or 4 th year pursuing a degree in a scientific discipline. Must be returning to school in the Fall Term OR has graduated within the 1 year of the start of the program. Must be available to work full time, 40 hours a week. Must be currently enrolled as a full-time student at an accredited U.S. based university or college and enrolled in the fall term after the completion of the internship OR have graduated within 1 year of the start of the program. Must be able to relocate if necessary and work at the designated site for the duration of the internship for on-site, hybrid roles. Benefits of a BioMarin Internship: Paid hourly wage, paid company holidays, and sick time Apply skills and knowledge learned in the classroom to on-the-job experiences Comprehensive, value-added project(s) Develop skills specific to your major. Opportunities for professional development by building relationships and learning about other parts of the business. Participate in company all hands meetings, monthly community lunches Corporate office amenities such as: 24/7 on-site gym, coffee truck, snacks Access to Employee Resource Groups Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. In the U.S., the salary range for this position is $24 to $27 per hour, which factors in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.
    $24-27 hourly Auto-Apply 57d ago
  • Intern, Skeletal Analytical Research

    Biomarin Pharmaceutical 4.6company rating

    San Rafael, CA jobs

    Description Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. SUMMARY:The BioMarin Summer Internship Program will enable students to gain valuable experience and knowledge of the processes and systems within BioMarin, while gaining an insight into the pharmaceutical/biotech industry. Over the course of 10 - 12 weeks our interns gain industry experience while working alongside our talented team on meaningful projects. BioMarin's Research & Development (R&D) group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients' lives. Within R&D, we have an opening for a motivated Summer Intern to join our Skeletal and CNP Therapeutic Area Analytical Group. This internship offers a unique opportunity to gain hands-on experience by working on a laboratory-based project that supports and contributes to drug development. JOB DESCRIPTION/PROJECT: Work closely with a scientist on a dedicated research project Gain practical experience in molecular biology, analytical and biochemical assays Apply laboratory techniques, which may include immunoassays, microscopy, imaging, PCR/qPCR, immunohistochemistry (IHC), immunofluorescence (IF), and other staining techniques Design, conduct, and interpret experiments Present project updates at group meetings and project summary to the broader department at the end of the summer. Responsibilities Conduct bench experiments under the guidance of a scientist mentor Apply techniques such as immunoassays, microscopy and imaging, PCR/qPCR, IHC, IF, and other analytical techniques Maintain detailed records of experimental design, procedures, and results in electronic laboratory notebooks. Participate in group discussions and present project updates, including a final project summary to the broader department at the end of summer. Theoretical knowledge: Microscopy and imaging techniques Immunohistochemistry (IHC), immunofluorescence (IF), and other analytical techniques Mammalian cell culture PCR/qPCR Immunoassays Other molecular and biochemical assays Qualifications/Eligibility: Student pursuing a bachelor's degree in scientific discipline Must be returning to school in the Fall Term OR has graduated within the 1 year of the start of the program. Must be available to work full time, 40 hours a week. Must be currently enrolled as a full-time student at an accredited U.S. based university or college and enrolled in the fall term after the completion of the internship OR have graduated within 1 year of the start of the program. Must be able to relocate if necessary and work at the designated site for the duration of the internship for on-site, hybrid roles. Benefits of a BioMarin Internship: Paid hourly wage, paid company holidays, and sick time Apply skills and knowledge learned in the classroom to on-the-job experiences Comprehensive, value-added project(s) Develop skills specific to your major. Opportunities for professional development by building relationships and learning about other parts of the business. Participate in company all hands meetings, monthly community lunches Corporate office amenities such as: 24/7 on-site gym, coffee truck, snacks Access to Employee Resource Groups Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. In the U.S., the salary range for this position is $24 to $27 per hour, which factors in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.
    $24-27 hourly Auto-Apply 47d ago
  • 2026 Summer Intern - Research Oncology

    Genentech 4.5company rating

    Senior research fellow job at Genentech

    2026 Summer Intern - Research Oncology The Research Oncology department serves as the engine of innovation within gRED (Genentech Research and Early Development). Our mission is simple yet audacious: to pursue groundbreaking science that transforms the standard of care for patients with the most complex cancers. This internship position is located in South San Francisco, on-site. The Opportunity * Literature search: Your goal is to identify "knowledge gaps" that our project can address, turning academic theory into actionable research hypotheses. * Mastery of Scientific Principles: You will work closely with your mentor to deeply understand the biological principles of our project. * Experimental Design & Optimization: You will actively design your own experiments. This includes calculating necessary concentrations, selecting appropriate controls and determining the most effective assays to answer specific biological questions. * Hands-on Bench Execution: You will lead the execution of your designed experiments in our state-of-the-art labs. * Data analysis & Presentation: You will analyze your findings, create professional-grade figures, and present your data during our group meetings. Program Highlights * Intensive 12-weeks, full-time (40 hours per week) paid internship. * Program start dates are in May/June 2026. * A stipend, based on location, will be provided to help alleviate costs associated with the internship. * Ownership of challenging and impactful business-critical projects. * Work with some of the most talented people in the biotechnology industry. Who You Are Required Education: You meet one of the following criteria: * Must be pursuing a Bachelor's Degree (enrolled student). * Must have attained a Bachelor's Degree (not currently enrolled in a graduate program). Required Majors: Biology, Molecular Biology, Immunology, Cell Biology. Required Skills: * Cell Culture: Maintaining and propagating various cell lines, including primary immune. * Mammalian Cell Culture. * Laboratory Rigor: pipetting, solution preparation, and documentation in electronic lab notebooks (ELN). * Ability to perform basic scientific calculations (molarity, dilutions) and statistical analyses to biological data. * Software Proficiency: Familiarity with data analysis tools such as Microsoft Excel, GraphPad Prism, or FlowJo. * Protein Analysis: (e.g., Western Blot, ELISA, or basic Flow Cytometry). Preferred Knowledge, Skills, and Qualifications * Excellent communication, collaboration, and interpersonal skills. * Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion. * Performing Peripheral Blood Mononuclear Cell (PBMC) isolation from blood samples and T cell isolation from PBMC. * Flow Cytometry: Preparing samples, running experiments on the flow cytometer, and performing basic data analysis for immunophenotyping and functional assays. Relocation benefits are not available for this job posting. The expected salary range for this position based on the primary location of California is $45.00 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
    $45 hourly 10d ago
  • 2026 Summer Intern - Discovery Chemistry - Analytical Research

    Genentech 4.5company rating

    Senior research fellow job at Genentech

    ** **2026 Summer Intern - Discovery Chemistry - Analytical Research** The Analytical Research group is part of the Discovery Chemistry department in the Drug Discovery organization. Our team focuses on developing structure elucidation, high-throughput purification, and physicochemical screening techniques to support the discovery and development of novel molecules. Our mission is to deliver high-quality analytical data that guide molecular design, process development, and quality control. We apply state-of-the-art techniques-including chromatography, mass spectrometry, and NMR spectroscopy-to elucidate chemical structures, reaction mechanisms, and stability profiles. We are passionate about scientific rigor, innovation, and cross-functional collaboration to bring transformative medicines to patients. This internship position is located in **South San Francisco, on-site.** **The Opportunity** + Contribute to the development of real-time analytical strategies for macrocyclic peptides. + The project focuses on applying machine learning to analytical chromatography to help enable preparative separation. + Develop and optimize analytical methods (HPLC, LC-MS, UV-Vis) for peptides. + Develop a machine learning model to predict optimal separation conditions. + Summarize and present experimental findings to multidisciplinary teams. + This internship offers hands-on experience with advanced analytical instrumentation and exposure to a cross-functional research environment focused on next-generation therapeutic modalities. **Program Highlights** + **Intensive 12-weeks, full-time (40 hours per week) paid internship.** + **Program start dates are in May/June 2026.** + **A stipend, based on location, will be provided to help alleviate costs associated with the internship.** + Ownership of challenging and impactful business-critical projects. + Work with some of the most talented people in the biotechnology industry. **Who You Are** **Required Education:** Must be pursuing a Bachelor's Degree (enrolled student). **Required Majors:** Chemistry, Biochemistry, Pharmaceutical Chemistry, or a related field. **Required Skills:** + Foundational knowledge and experience of organic chemistry. + Basic understanding and hands-on experience in chromatography (HPLC/LC-MS) and spectroscopy (UV-Vis). + Mass Spectrometry. + Proficiency in Python. + Strong experimental and data interpretation skills. + Enthusiasm for problem solving and innovation in analytical chemistry. **Preferred Knowledge, Skills, and Qualifications** + Experience with deep learning frameworks (e.g. PyTorch). + Experience operating or interpreting data from HPLC or LC-MS. + Prior laboratory experience. + Proficiency with literature search. + Excellent communication, collaboration, and interpersonal skills. + Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion. **Relocation benefits are not available for this job posting.** The expected salary range for this position based on the primary location of California is $45.00 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .
    $45 hourly 7d ago
  • 2026 Summer Intern - Discovery Chemistry - Analytical Research

    Genentech 4.5company rating

    Senior research fellow job at Genentech

    The Analytical Research group is part of the Discovery Chemistry department in the Drug Discovery organization. Our team focuses on developing structure elucidation, high-throughput purification, and physicochemical screening techniques to support the discovery and development of novel molecules. Our mission is to deliver high-quality analytical data that guide molecular design, process development, and quality control. We apply state-of-the-art techniques-including chromatography, mass spectrometry, and NMR spectroscopy-to elucidate chemical structures, reaction mechanisms, and stability profiles. We are passionate about scientific rigor, innovation, and cross-functional collaboration to bring transformative medicines to patients. This internship position is located in South San Francisco, on-site. The Opportunity Contribute to the development of real-time analytical strategies for macrocyclic peptides. The project focuses on applying machine learning to analytical chromatography to help enable preparative separation. Develop and optimize analytical methods (HPLC, LC-MS, UV-Vis) for peptides. Develop a machine learning model to predict optimal separation conditions. Summarize and present experimental findings to multidisciplinary teams. This internship offers hands-on experience with advanced analytical instrumentation and exposure to a cross-functional research environment focused on next-generation therapeutic modalities. Program Highlights Intensive 12-weeks, full-time (40 hours per week) paid internship. Program start dates are in May/June 2026. A stipend, based on location, will be provided to help alleviate costs associated with the internship. Ownership of challenging and impactful business-critical projects. Work with some of the most talented people in the biotechnology industry. Who You Are Required Education: Must be pursuing a Bachelor's Degree (enrolled student). Required Majors: Chemistry, Biochemistry, Pharmaceutical Chemistry, or a related field. Required Skills: Foundational knowledge and experience of organic chemistry. Basic understanding and hands-on experience in chromatography (HPLC/LC-MS) and spectroscopy (UV-Vis). Mass Spectrometry. Proficiency in Python. Strong experimental and data interpretation skills. Enthusiasm for problem solving and innovation in analytical chemistry. Preferred Knowledge, Skills, and Qualifications Experience with deep learning frameworks (e.g. PyTorch). Experience operating or interpreting data from HPLC or LC-MS. Prior laboratory experience. Proficiency with literature search. Excellent communication, collaboration, and interpersonal skills. Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion. Relocation benefits are not available for this job posting. The expected salary range for this position based on the primary location of California is $45.00 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
    $45 hourly Auto-Apply 8d ago
  • 2026 Summer Intern - Research Oncology

    Genentech 4.5company rating

    Senior research fellow job at Genentech

    The Research Oncology department serves as the engine of innovation within gRED (Genentech Research and Early Development). Our mission is simple yet audacious: to pursue groundbreaking science that transforms the standard of care for patients with the most complex cancers. This internship position is located in South San Francisco, on-site. The Opportunity Literature search: Your goal is to identify "knowledge gaps" that our project can address, turning academic theory into actionable research hypotheses. Mastery of Scientific Principles: You will work closely with your mentor to deeply understand the biological principles of our project. Experimental Design & Optimization: You will actively design your own experiments. This includes calculating necessary concentrations, selecting appropriate controls and determining the most effective assays to answer specific biological questions. Hands-on Bench Execution: You will lead the execution of your designed experiments in our state-of-the-art labs. Data analysis & Presentation: You will analyze your findings, create professional-grade figures, and present your data during our group meetings. Program Highlights Intensive 12-weeks, full-time (40 hours per week) paid internship. Program start dates are in May/June 2026. A stipend, based on location, will be provided to help alleviate costs associated with the internship. Ownership of challenging and impactful business-critical projects. Work with some of the most talented people in the biotechnology industry. Who You Are Required Education: You meet one of the following criteria: Must be pursuing a Bachelor's Degree (enrolled student). Must have attained a Bachelor's Degree (not currently enrolled in a graduate program). Required Majors: Biology, Molecular Biology, Immunology, Cell Biology. Required Skills: Cell Culture: Maintaining and propagating various cell lines, including primary immune. Mammalian Cell Culture. Laboratory Rigor: pipetting, solution preparation, and documentation in electronic lab notebooks (ELN). Ability to perform basic scientific calculations (molarity, dilutions) and statistical analyses to biological data. Software Proficiency: Familiarity with data analysis tools such as Microsoft Excel, GraphPad Prism, or FlowJo. Protein Analysis: (e.g., Western Blot, ELISA, or basic Flow Cytometry). Preferred Knowledge, Skills, and Qualifications Excellent communication, collaboration, and interpersonal skills. Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion. Performing Peripheral Blood Mononuclear Cell (PBMC) isolation from blood samples and T cell isolation from PBMC. Flow Cytometry: Preparing samples, running experiments on the flow cytometer, and performing basic data analysis for immunophenotyping and functional assays. Relocation benefits are not available for this job posting. The expected salary range for this position based on the primary location of California is $45.00 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
    $45 hourly Auto-Apply 11d ago
  • Postdoctoral Fellow- Biological Chemistry, Kirchhofer lab

    Genentech 4.5company rating

    Senior research fellow job at Genentech

    A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech. The Opportunity We are seeking a highly motivated postdoctoral fellow to join the laboratory of Dr. Daniel Kirchhofer in the Department of Biological Chemistry at Genentech. This position offers an exciting opportunity to use state-of-the-art peptide display technologies - including phage and mRNA display of macrocyclic and cystine-knot peptide libraries - to discover peptides that modulate the function of therapeutically relevant protein targets. A major focus will be on members of the type II transmembrane serine protease family, cell-surface enzymes implicated in disease processes such as viral entry. In parallel, you will engineer disulfide-constrained peptide libraries designed to engage challenging, flat protein-protein interfaces, using a newly developed scaffold with a unique surface topology, and will leverage machine-learning-assisted methods for peptide sequence optimization. To elucidate mechanisms of peptide activity, the successful candidate will apply a broad range of biochemical, biophysical, structural, and cellular methods. The ideal applicant is an independent, creative scientist who thrives in a collaborative, team-oriented environment. The position offers extensive opportunities to interact with the vibrant Genentech postdoctoral community as well as scientists across multiple departments. Who You Are: A Ph.D. in biochemistry, biophysics, structural biology or related discipline and a proven record of productivity in their graduate career as demonstrated by first-author publications. Preferred Qualifications: * Strong experience in molecular biology * Expertise in engineering, expressing and purifying proteins * Experience with directed evolution (yeast, phage, mRNA display, etc.) is preferred * Experience in peptide chemistry is a plus * Proficiency in surface plasmon resonance or biolayer interferometry * Proficient in structural biology (crystallography and or cryo-EM) is a plus * Experience with tissue culture, cell-based assays * Strong analytical, collaborative, communication and organizational skills For information about the Kirchhofer Lab at Genentech, please go to: **************************************************************** Postdoc Program Elevate your research career to new heights with Genentech's Postdoctoral Program! Join a prestigious community of early career scientists and kick-start your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Genentech strategic ambitions. The postdoc program is designed to empower recent Ph.D. graduates to conduct world-class research, publish in top-tier journals, and build a robust scientific network. By joining us, you will receive the mentorship and support necessary to develop into an independent scientist and leader. The Genentech Postdoc Program provides access to world-class seminars, professional development workshops, and networking opportunities. Apply now to Genentech Postdoctoral Program and unlock your full potential! The expected salary range for this position based on the primary location of California is $100,000 to $106,500 . Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below. Benefits Relocation benefits are available for this job posting. #LI-PL1 #postdoc Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
    $100k-106.5k yearly 13d ago
  • Senior Scientist, Omics - R&D Data Science & Digital Health - Neuroscience

    Johnson & Johnson 4.7company rating

    San Diego, CA jobs

    At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at ******************* Job Function: Data Analytics & Computational Sciences Job Sub Function: Data Science Job Category: Scientific/Technology All Job Posting Locations: Cambridge, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America Job Description: Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at *******************/innovative-medicine Johnson & Johnson Innovative Medicine is recruiting for a Senior Scientist, Omics - R&D Data Science & Digital Health to focus on Neurodegeneration and/or Neuropsychiatry. This position can be located in either Cambridge, MA; Spring House, PA, or San Diego, CA, United States of America; or Beerse, Antwerp, Belgium, and may require approximately 10% domestic and international travel. Please note that this role is available across multiple countries and may be posted under different requisition numbers to align with local requirements. While you are welcome to apply to any or all of the postings, we recommend focusing on the specific country(s) that align with your preferred location(s): USA - Requisition Number: R-052115 Belgium - Requisition Number: R-053691 Role Summary Our Neuroscience Data Science & Digital Health (NS DSDH) team integrates the power of multi-omics, digital health technologies and clinical/real-world evidence (RWE) data to accelerate the delivery of transformational therapies for Neurodegeneration, Neuropsychiatry and Ophthalmology. We drive decision-making and breakthroughs from molecular discovery to clinical trials by partnering along the pipeline to ensure that data science & digital health strategies are embedded in every program. We are seeking a Senior Scientist, Omics to join our NS DSDH team focused on Neuropsychiatry and/or Neurodegeneration. In this role, you will contribute to our precision neuroscience strategy by contributing to projects that bring to bear bioinformatics, artificial intelligence and machine learning as needed to link molecular signatures (genetics, gene expression, proteomics) to disease stage and progression, mechanisms of action, and disease endophenotypes. You will be part of a cross-functional team of data science leaders and partner closely with the Neuroscience Therapeutic Area, Quantitative Sciences, and Discovery Product Development and Supply (DPDS). This position offers the opportunity to transform how we understand disease biology, identify novel targets, stratify patients, and deliver better outcomes for people living with neuropsychiatric and neurodegenerative disorders. Key Responsibilities * Implement innovative data science projects to uncover novel therapeutic targets, optimize patient stratification, and identify precision biomarkers by deriving insights from multi-omics data linked to brain biology and neuropsychiatric/neurodegenerative disease mechanisms * Work in multi-disciplinary teams, composed of discovery scientists, clinicians, computational biologists and biomarker experts to support the precision neuroscience strategy for programs in the Neuropsychiatry/Neurodegeneration portfolio * Remain current on the constantly evolving landscape of neuroscience, neurodegeneration, and neuropsychiatry, omics, bioinformatics and AI/ML research in search of better approaches for accelerating and prioritizing our portfolio based on biological insights. * Build strong relationships with internal partners and key academic collaborators, and consortia to position the company at the forefront of data-driven neuroscience. Qualifications * PhD in neuroscience, computational biology, bioengineering, biostatistics, or a related field is required. * Experience working hands-on deriving insights from high-dimensional molecular data - particularly genetic (GWAS, WGS), RNAseq, proteomics and/or single-cell data is required. * Proficiency in R, Python, or similar programming languages is required. * Experience translating data into executable action plans is required. * Ability to clearly communicate technical work to a diverse audience is required. * Proven track record of scientific contributions in this field with first author publications in high-impact journals is strongly preferred. * Background and experience working in Neuropsychiatry/Neurodegeneration is preferred. * Experience in applying data-driven methods in the context of target discovery and validation, translational science and/or patient stratification is preferred. * Familiarity with machine learning and innovative AI methodologies is preferred. * Up to approximately 10% yearly travel is required (International, Domestic) This position currently has the option to follow a hybrid schedule of 3 days per week working on-site and 2 days per week working remotely (no fully remote option available) and can be located in one of our office locations in either Cambridge, MA, Spring House, PA, or San Diego, United States of America, or Beerse, Belgium, and may require approximately 10% travel domestic and international. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please contact us via *******************/contact-us/careers or internal employees contact AskGS to be directed to your accommodation resource. The anticipated base pay range for this position in the US is $109,000 to $174,800. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation's performance over a calendar/performance year. Bonuses are awarded at the Company's discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company's consolidated retirement plan (pension) and savings plan (401(k)). Employees are eligible for the following time off benefits: Vacation - up to 120 hours per calendar year Sick time - up to 40 hours per calendar year Holiday pay, including Floating Holidays - up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year Additional information can be found through the link below. ********************************************* The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market. #LI-SL #JNJDataScience #JNJIMRND-DS #JRDDS #LI-Hybrid Required Skills: Preferred Skills: Advanced Analytics, Business Intelligence (BI), Coaching, Collaborating, Critical Thinking, Data Analysis, Database Management, Data Privacy Standards, Data Reporting, Data Savvy, Data Science, Data Visualization, Econometric Models, Process Improvements, Technical Credibility, Technologically Savvy, Workflow Analysis
    $109k-174.8k yearly Auto-Apply 3d ago

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