Genomics scientist job description

Data Driven Bioscience (DDB) has developed a revolutionary approach to cancer diagnosis by connecting a novel genomic assay with intelligent software. DDB is well-funded by some of the top venture capital firms and paying customers. We are looking to expand our wet lab team to develop the next generation of library prep kits.

We are seeking a highly motivated Associate Scientist/Development Associate to assist in the expansion of our assay development team and our product line. The ideal candidate would have a strong work ethic with a background in molecular biology and with proven hands.
Primary Responsibilities:

· Assist in the development of novel next generation sequencing (NGS) library preparation kits

· Perform NGS on patient samples

· Develop experiments to test kit parameters, and data interpretation

· Train new customers to perform the assay

· Assist in upstream manufacturing processes

· Maintain lab equipment and inventory

Required Qualifications and Experience:

· B.S. or M.S. in Molecular Biology or related field with at least 1-2 years of laboratory experience

\* Experience with NGS strongly preferred.

· Hands on experience with basic molecular biology methods, such as nucleic acid purification, primer design, PCR. Experience in NGS library preparation is preferred

· Proven ability to independently plan and execute experiments and troubleshoot

· Strong communication skills, including written and verbal communication

This position will culminate in the implementation of the a novel NGS-based approach to cancer diagnostics. The candidate will be at the forefront of cancer research and will play a critical role in the direction and growth of the company.

The position requires ~15% travel to interact with customers and to attend biomedical conferences.

Data Driven Bioscience offers a highly competitive salary, as well as employee stock options.

If you would like to be part of the future of cancer diagnostics, please apply with your resume and we will contact you promptly.

Job Type: Full-time

Pay: $45,000.00 - $80,000.00 per year

Benefits:
* Dental insurance
* Health insurance
* Paid time off
* Vision insurance
Schedule:
* Monday to Friday

Ability to commute/relocate:
* Durham, NC 27707: Reliably commute or planning to relocate before starting work (Required)

Education:
* Bachelor's (Preferred)

Experience:
* Laboratory experience: 1 year (Preferred)

Work Location: One location

**Why Patients Need You**

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

**What You Will Achieve**

Pfizer is using human genetics and functional genomics to inform the discovery and validation of new drug targets and the mechanistic understanding of disease pathology. Pfizer's Functional Genomics group, with labs in both Cambridge and New York City, is launching the Functional Genomics Technology Center at our Cambridge site. Working closely with disease biologists across therapeutic areas, the Functional Genomics Tech Center applies the latest experimental gene editing tools and novel screening approaches to bring the best new targets into the portfolio and deepen our knowledge of targets under development.

We are seeking a highly motivated and accomplished molecular biologist, with experience in gene editing or functional genomics screening, to contribute their technical expertise to the success of the new Functional Genomics Tech Center in Cambridge. This is an exciting opportunity to apply cutting-edge methods and contribute to the target portfolio of one of the world's leading developers of novel therapeutics.

**How You Will Achieve It**

+ Apply a versatile repertoire of gene editing, molecular biology, and cell culture techniques to rapidly test the functional consequences of genes and variants in appropriate cell-based model systems

+ Perform functional genomics screens in pooled and arrayed formats, including with FACS and imaging-based readouts

+ Use next generation sequencing to assess gene editing and to readout pooled screen results

+ Evaluate new gene editing and screening approaches and help develop improved methods

+ Support general lab operations, including lab safety

+ Collaborate closely and maintain productive relationships with disease area biologists and colleagues in the other Tech Center (NGS, FACS, Imaging, and Mass Spec)

**Qualifications**

**Must-Have**

+ MS with 3+ years or BS with 5+ years of laboratory experience in molecular biology or related field.

+ Track record of successful contribution to research projects, preferably utilizing gene editing methodologies, in an industry setting or comparable context in academia.

+ Expertise in molecular and cell biology, including significant experience with mammalian cell tissue culture

+ Experience with gene editing and functional genomics screening

+ Previous experience in disease-focused research, particularly in immune/inflammatory diseases, metabolic diseases, or cancer

+ Ability to balance multiple projects simultaneously, prioritize work, and establish strong relationships with multiple stakeholders

+ Excellent interpersonal and communication skills to effectively collaborate with other scientists

**Nice-to-Have**

+ Experience with next generation sequencing workflows

+ Experience evaluating and implementing new techniques, particularly in the field of gene editing

+ Familiarity with data analysis tools, particularly for pooled screening, FACS, or image analysis

**Other Job Details**

+ Work Location Assignment:On Premise. On Premise colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.

\#LI-PFE

Relocation assistance may be available based on business needs and/or eligibility.

**Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.**

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

\#LI-PFE

The Knott laboratory at Cedars-Sinai Medical Center is searching for a Postdoctoral Scientist with a strong background in tumor biology and the immune microenvironment to lead single cell-based omics studies of immunotherapy clinical trials being carried out at the medical center. The scientist will manage a team of laboratory technicians through the processing of clinical trial biopsies for profiling with single cell RNA and ATAC sequencing as well as other emerging technologies. Additionally, our laboratory analyzes the clinical samples with spatial profiling methods such as Co-Detection by Indexing, which allows us to directly study interactions between neighboring cells within the tumor that may govern the response to therapy. We are currently analyzing trials to study the effects of combination immunotherapies in patients with triple negative and estrogen receptor positive breast cancers. We are also beginning trials in patients with early as well as late stage Her2 positive disease. We expect all analyses of these cutting-edge clinical trials will result in high-profile publications in top-tier scientific journals. To learn more, please visit: Knott Research Lab | Cedars-Sinai.

Are you ready to be a part of breakthrough research?

Working independently but in close cooperation and in consultation with Dr. Knott and other Research Scientists, the Postdoc will perform routine and complex laboratory procedures throughout training period. May develop, adapt, and implement new research techniques and protocols, analyze and interpret data.

#Jobs-Indeed

Primary Job Duties and Responsibilities:

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• May assist in preparation of grant proposals, but is not responsible for generating grant funds.
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• May participate in publications and presentations as author or co-author.
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• Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
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• Analyzes, interprets, summarizes and compiles data.
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• Operates and maintains equipment and instruments.
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Education:

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  Doctorate Degree in Cancer Biology, Immunology or a related field, required.

  
  
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Experience and Skillset:

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• Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.
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• Experience analyzing murine or human tumor microenvironments with single cell resolution methods.
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• Molecular biology skills are also required, as this scientist will be responsible for guiding laboratory technicians through specific analytical techniques mentioned.
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• Ability to interpret high-dimensional data and a willingness to work in a collaborative setting with clinicians, immunologists and computational scientists is essential.
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• Works independently on research projects designed by a mentor (typically the PI) within area of specialization.
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• Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis, and operation and maintenance of specialized equipment.
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• Knowledge of safety standards and maintenance of specialized equipment.
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Working Title: Postdoctoral Scientist - Knott Lab - Bioinformatics & Functional Genomics
Department: BMS - Bioinfo & Func Genomics
Business Entity: Academic / Research
Job Category: ,Academic/Research,Academic/Research
Job Specialty: Postdoctoral
Position Type: Full-time
Shift Length: 8 hour shift
Shift Type: Day