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Prior to the land opening the Southern Kansas Railway (later the Atchison, Topeka and Santa Fe Railway, AT&SF) built a north-south line from the Kansas-Oklahoma border to Purcell, Indian Territory, in 1886–87.
Along that line a railroad station known as Deer Creek, at the present location of Guthrie, was established in March 1887.
In 1905 Carry Nation brought her prohibition activities to Guthrie, which then abounded in saloons and gambling halls. It was founded virtually overnight on April 22, 1889, with the opening of Indian lands to settlement.
Like other towns in Oklahoma Territory, the four Guthrie towns were served by provisional governments until the Organic Act was passed on May 2, 1890.
Consolidation of the four towns occurred in the summer 1890.
The short-lived Oklahoma University opened on September 12, 1892, and ambitiously offered kindergarten through high school classes as well as degrees in liberal arts and sciences, business courses, a normal school for teachers, and professional programs in law, pharmacy, dentistry, and medicine.
In 1902 the Denver, Enid and Gulf Railroad (later the AT&SF) built a line connecting Guthrie and Enid to the northwest.
Theodore Roosevelt signed the Oklahoma Enabling Act on June 16, 1906, which provided for creating the State of Oklahoma and writing the state constitution.
Guthrie, city, seat (1907) of Logan county, central Oklahoma, United States, on Cottonwood Creek near its junction with the Cimarron River, north of Oklahoma City.
Guthrie values are founded on the life and work of Donald Guthrie, MD, who came to the booming railroad town of Sayre, Pa. in 1910.
Guthrie, city, seat (1907) of Logan county, central Oklahoma, United States, on Cottonwood Creek near its junction with the Cimarron River, north of Oklahoma City. It served as the capital of the Oklahoma Territory, and the state government was maintained there until 1910, when it was moved to Oklahoma City.
In September 1911 the new Methodist University of Oklahoma was opened.
Lula Klingman Pratt, "History of Guthrie, Oklahoma" (M.A. thesis, University of Oklahoma, 1930).
Olin Edward Butler, "An Economic Survey of Guthrie" (M.A. thesis, Oklahoma A&M College, 1932).
Gerald Forbes, Guthrie: Oklahoma's First Capital (Norman: University of Oklahoma Press, 1938).
The Foundation was established in 1942 with an initial gift of $25,000 from Doctor Guthrie.
Around 1948 the Oklahoma Factory Manufacturing Company moved from Oklahoma City to Guthrie.
A new facility was built in 2013 and offers a wide range of inpatient and outpatient services including sub-acute and ventilator management programs and is a Level IV Trauma Center.
Guthrie Corning Hospital, located in Corning, N.Y., opened a new 65-bed hospital and regional cancer center in 2014.
In 2014, under a broader organizational re-structure the Foundation was re-named the Donald Guthrie Foundation however, still maintained its same mission statement.
Guthrie Cortland Medical Center, an independent, nonprofit, 162-bed acute care facility with an attached 80-bed residential care facility, joined the Guthrie healthcare system in January 2019.
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