Research Fellow jobs at Hospital for Special Surgery

We are excited to invite applications for a non-tenure-track Assistant Professor position in the Laboratory of Immunity and Tissue Regeneration at the Icahn School of Medicine at Mount Sinai (***************** This is a unique opportunity to join a vibrant, interdisciplinary environment at one of the world's leading academic medical centers, located in the heart of New York City. Mount Sinai is a premier hospital system and research hub, offering unparalleled access to diverse patient populations, cutting-edge clinical programs, and world-class scientific resources. We are seeking an exceptional early-career scientist with expertise in molecular biology (cloning, CRISPR, epigenetics) and in vivo models who is eager to push the boundaries of discovery. The position offers the chance to explore the molecular drivers of tissue repair, chronic inflammation, inflammatory memory, and their impact on disease relapse and tissue dysfunction. The successful candidate will have the independence to lead high-impact projects with both fundamental and translational dimensions, while benefiting from extensive collaborations across Mount Sinai and with external partners in academia, biotechnology, and the pharmaceutical industry. This role provides an outstanding platform for scientific creativity, career development, and meaningful contributions to advances in human health. PhD, MD, or equivalent in Molecular Biology, Immunology, Epigenetics, or a related field Minimum of 4 years of postdoctoral research experience with demonstrated expertise in molecular biology (cloning, genome editing, epigenetics) and in vivo biology (murine models, human tissue) Proven ability to design and execute complex experiments, including epigenetic profiling, chromatin/imaging assays, and in vivo functional studies Strong publication record in relevant fields Demonstrated ability (or clear potential) to secure independent funding Excellent communication and organizational skills Commitment to collaboration within a dynamic, multidisciplinary research environment Compensation range from 105K to 150K (not including bonuses / incentive compensation or benefits). Salary Disclosure Information: Mount Sinai Health System provides a salary range to comply with the New York City law on Salary Transparency in Job Advertisements. Actual salaries depend on a variety of factors, including experience, specialties, historical productivity, historical collections, and hospital/community need. As such, an actual salary may fall closer to one or the other end of the range, and in certain circumstances, may wind up being outside of the listed salary range. The salary range listed is for full-time employment and does not include bonuses / incentive compensation or benefits. Please specify Job Title of interest and send CV with Cover Letter to: Physician Recruitment Department Mount Sinai Health System ************************************ Lead cutting-edge research: Design, plan, and execute molecular, in vitro, and in vivo experiments to uncover mechanisms of inflammatory memory, epigenetic regulation, and tissue adaptation in chronic inflammation, with a focus on skin and other barrier tissues. Innovate at the bench: Develop and refine molecular and genomic tools, including cloning strategies, chromatin and epigenetic assays (e.g., chromatin accessibility, histone modifications, enhancer/promoter regulation), single-cell epigenetics, and spatial transcriptomics, to dissect regulatory networks. Drive funding success: Lead or co-lead grant proposals (NIH, foundations, etc.), manage reporting and progress updates, and contribute to long-term resource planning. Manage operations: Oversee day-to-day laboratory activities along-side the laboratory manager, supervise technical staff, coordinate with Icahn core facilities, and ensure compliance with IRB, IACUC, and other institutional guidelines. Mentor and inspire: Train junior scientists, postdocs, and collaborators in molecular and in vivo techniques, data interpretation, and rigorous experimental design. Build collaborations: Coordinate interdisciplinary studies with internal and external partners, including clinical teams, computational/omics cores, and laboratories focused on inflammation and regenerative biology. Advance knowledge: Publish high-impact manuscripts, present at national and international conferences, and help elevate the program's scientific profile.

The Associate Researcher is an entry laboratory research position, responsible for conduct of routine and standardized experiments using techniques specific to the assigned research project under the supervision of the Principal Investigator or a senior researcher. This individual assists in the interpretation of research outcomes and may be responsible for lab and clerical support. S/he analyzes and assists in interpreting research outcomes. Bachelors degree in science or related field preferred, or combination of relevant research experience and education 0-2 years of research/laboratory experience Compensation Statement The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $16.50 - $34.12 Hourly. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits. , 036 - Renal MSH - ISM, Icahn School of Medicine 1. Under direct supervision, conducts routine and standardized experiments using appropriate research techniques specific to subject matter of the research project. 2. Analyzes and assists in interpreting laboratory results. 3. Performs assays to support research studies. 4. Maintains laboratory environment and assists in the upkeep of appropriate inventory; may include ordering of supplies. 5. Logs and tests samples; prepares and submits laboratory materials and specimens for shipment. 6. Assists in the collection, analysis and review of experimental data for publication and presentation. 7. Performs other related duties.

The Research Program Coordinator will be responsible for research projects regarding the STICU, Trauma Service, and General Surgery. It will be the duty of the coordinator to maintain all trauma research efforts, research assistants, and generate grant proposals to fund trauma-related research endeavors. " -Masters degree in Public Health (MPH). -Minimum 2 years of experience in a research role including statistical analysis (STATA), study design, and study coordination. Experience managing staff and demonstrated experience in writing grant proposals preferred. -Board Certification in Public Health preferred. -Microsoft Office suite (Word, Excel, Outlook) proficiency required. Use of STATA or equivalent required. -General Skills: Oral and written communication skills Presentation skills Project management skills Supervisory management skills Non-Bargaining Unit, A49E - Surgery - EHC, Elmhurst Hospital Center Duties and Responsibilities: -Develop IRB and submit proposals within specified deadlines. -Schedule regular meetings to monitor the progress of the research projects. -Review ideas and develop with new research projects and proposals. -Review grants possibilities; and prepare grant proposals. -Generate statistical inputs to assess data and power the identified research projects. -Coordinate participation of residents/students/attending on the research projects. -Provide input as to study design and analysis. -Supervise and manage the Research Assistants and other itinerant staff needed for research projects including but not limited to performance management. -Proficient in Microsoft Office applications (Word, Excel, PowerPoint, etc.) -Other duties as assigned.

The Associate Researcher will be responsible for research projects regarding the STICU, Trauma Service, and General Surgery. It will be the duty of the researcher to maintain all trauma research efforts, research assistants and generate grant proposals to fund trauma-related research endeavors -Microsoft Office suite (Word, Excel, Outlook) proficiency required. Use of STATA or equivalent required. -Master's degree in Public Health (MPH). -Minimum 2 years of experience in a research role including statistical analysis (STATA), study design, and study coordination. Experience managing staff and demonstrated experience in writing grant proposals preferred. -Board Certification in Public Health preferred. -General skills required: Oral and written communication skills, presentation skills, project management skills and supervisory management skills. 1. Develop IRB and submit proposals within specified deadlines. 2. Schedule regular meetings to monitor the progress of the research projects. 3. Review ideas and develop with new research projects and proposals. 4. Review grants possibilities; and prepare grant proposals. 5. Generate statistical inputs to assess data and power the identified research projects. 6. Coordinate participation of residents/students/attending on the research projects. 7. Provide input as to study design and analysis. 8. Supervise and manage the Research Assistants and other itinerant staff needed for research projects including but not limited to performance management. 10. Assist in organizing and writing manuscripts. 11. Maintain databases for ongoing research projects. 12. Present ongoing projects and updates at bi-weekly research meetings. 13. Assist in coordinating and communicating with other programs for multi-institutional studies. 14. Other duties as needed.

We seek a talented and motivated Research Associate I to assist in conducting a new NIH-funded study at the Icahn School of Medicine at Mount Sinai examining a new mechanism and therapy for comorbid health problems, including Alzheimer's disease, metabolic dysregulation, and more, in mouse models of Down Syndrome. The Research Associate is an entry or mid-level researcher, responsible for conducting and assisting in rodent research studies under the supervision of Dr. Ki Goosens and her collaborators in the Center for Translational Medicine and Pharmacology at Mount Sinai. The individual will conduct studies in mice. Primary responsibilities will include running experiments, collecting and processing tissues and blood samples, and running ELISAs and other assays to measure specific biomarkers. The individual will also organize and analyze data, help prepare research articles for publication, order reagents, perform tasks to maintain lab safety, and arrange data to meet archiving requirements. The individual will also present data in lab meetings, department retreats, and, potentially, at scientific conferences. Experience with genotyping of transgenic mice, performing RNAscope on different tissues, and running ELISAs, immunohistochemistry and/or Western blot is preferred. Experience with small animal surgery and rodent handling is required. Familiarity with multiple tissues/organ systems (brain, adipose, bone, etc.) a plus. Candidates must be comfortable interacting with people, work well in a team, and have an interest in translational science spanning the brain and periphery. Candidates should also be organized, able to troubleshoot or problem-solve, capable of meeting deadlines, and interested in actively contributing to a fast-paced, dynamic project. The majority of the individual's time and effort will be allocated to conducting the funded study as described above, but the individual may also assist with other ongoing lab projects as needed. The position provides an excellent opportunity for training, with likely authorship on papers and abstracts, and can serve as a stepping stone to graduate school or medical school, but it could also provide a long-term opportunity to work as a laboratory scientist. Candidates who can make at least two full years of commitment to this project are required. Bachelors or Masters degree in science or related field required 1 - 2 years of research/laboratory experience Conducts routine and standardized experiments using appropriate research techniques specific to subject matter of the research project. Analyzes and assists in interpreting moderately complex results. Analyzes and assists in interpreting laboratory results. Performs assays to support research studies. Maintains laboratory environment and assists in the upkeep of appropriate inventory; may include ordering of supplies. Logs and tests samples; prepares and submits laboratory materials and specimens for shipment. Assists in new and unexpected research experiments and techniques. Assists in the collection, analysis and review of experimental data for publication and presentation. Performs other related duties.

Details of Research Project: We are seeking a motivated individual to work as an associate researcher in our laboratory. The individual will have opportunities to interface with both clinical staff and basic scientists, making the position ideal for someone who is interested in broad exposure to the challenges associated with diagnosing, treating, and studying degenerative brain diseases (e.g., Alzheimer's disease, chronic traumatic encephalopathy, Parkinson's disease, etc.). The individual will be trained to deploy various approaches to study human brain diseases using stem cell models, multiscale analysis of human post-mortem brain tissues and gain exposure to challenges associated with treatment modalities, diagnosis, and research design. This role requires a bachelor?s degree in a science related discipline, such as Neuroscience, Biology, Chemistry, etc. Excellent organizational, interpersonal and communication skills Non-Bargaining Unit, 847 - Pathology, Molecular&Cell Based Medicine - ISM, Icahn School of Medicine, Pathology Technical Duties: (include any protocols) The laboratory uses a variety of techniques, including DNA/RNA sequencing, histology, confocal microscopy, stem cell culture, optogenetics, and biochemistry. Responsibilities include: Microscopy (e.g., immunohistochemistry, immunofluorescence, confocal microscopy) Cell culture (e.g., stem cell lines and fibroblast lines) Molecular biology and biochemistry (e.g., PCR, RT-PCR, DNA/RNA isolation, immunoblotting, etc.) Experience Required: Applicants must have experience working in a basic laboratory environment Applicants must have experience in neuroscience and brain research

We are seeking a medically trained Associate Researcher to support ongoing clinical research initiatives. This part-time position is ideal for a detail-oriented and self-motivated individual with a strong background in medicine or biomedical sciences who excels in academic writing and grant development. The Associate Researcher is an entry laboratory research position, responsible for conduct of routine and standardized experiments using techniques specific to the assigned research project under the supervision of the Principal Investigator or a senior researcher. This individual assists in the interpretation of research outcomes and may be responsible for lab and clerical support. S/he analyzes and assists in interpreting research outcomes. Bachelors degree in science or related field preferred, or combination of relevant research experience and education 0-2 years of research/laboratory experience Preferred Skills Advanced degree in medicine (MD, DO.); Prior experience in academic writing, grant preparation, or clinical research. Strong command of scientific writing and familiarity with citation management tools. Excellent organizational and communication skills. Ability to work independently and manage multiple deadlines. Assist in drafting, editing, and formatting research manuscripts for peer-reviewed journals; support the preparation of grant proposals, including literature reviews, data summaries, and budget justifications; collaborate with principal investigators and clinical teams to organize study materials and maintain documentation. Conduct background research and synthesize findings into clear, concise reports and Ensure compliance with IRB protocols and regulatory standards. Under direct supervision, conducts routine and standardized experiments using appropriate research techniques specific to subject matter of the research project. Analyzes and assists in interpreting laboratory results. Performs assays to support research studies. Maintains laboratory environment and assists in the upkeep of appropriate inventory; may include ordering of supplies. Logs and tests samples; prepares and submits laboratory materials and specimens for shipment. Assists in the collection, analysis and review of experimental data for publication and presentation. Performs other related duties.

The Icahn School of Medicine at Mount Sinai (ISMM) is an international leader in medical and scientific training, biomedical research, and patient care. It is the medical school for the Mount Sinai Health System, which includes seven hospital campuses, and has more than 5,000 faculty and nearly 2,000 students, residents and fellows. The Associate Researcher I is a laboratory research position, responsible for independent conduct of routine and standardized experiments. The individual assists in the interpretation of research outcomes, performs assays to support research studies, and assists in the clerical and supply aspects of the laboratory environment. This position is suitable for candidates who are willing to commit for a minimum period of 2 years. Bachelors or Masters degree in science or related field required No experience required. One year of research experience preferred. Conducts routine and standardized experiments using advanced research techniques specific to subject matter of the research project. Analyzes and assists in interpreting results. Analyzes and assists in interpreting laboratory results. Performs assays to support research studies. Maintains laboratory environment and assists in the upkeep of appropriate inventory; may include ordering of supplies. Logs and tests samples; prepares and submits laboratory materials and specimens for shipment. Assists in new and unexpected research experiments and techniques. Assists in the collection, analysis and review of experimental data for publication and presentation. Performs other related duties.

Under limited supervision, the Associate Researcher II conducts experiments using advanced techniques specific to the research project. Analyzes and assists in interpreting moderately complex results. Bachelors Degree in sciences or related field or equivalent experience 2 years in a research environment or 1 year plus Masters Degree in sciences or related field , 036 - Renal MSH - ISM, Icahn School of Medicine (in order of importance and/or frequency) 1.*Conducts experiments using advanced research techniques specific to subject matter of the research project. 2.*Analyzes and assists in interpreting moderately complex results. 3.*Performs assays to support research studies. 4.*Assists in new and unexpected research experiments and techniques. 5.*Assists in the collection, analysis and review of experimental data for publication and presentation. 6. May train less-experienced research staff and postdoctoral fellows in research techniques and use of equipment. 7. Performs other related duties *-indicates duty is essential as defined by the Americans with Disabilities Act (ADA)

Lab Technician - Peptide Drug Discovery Lab We are seeking a highly motivated Lab Technician to join our dynamic research team focused on peptide drug discovery. The ideal candidate will have a strong foundation in chemistry or biochemistry and a genuine interest in chemical biology work. The Associate Researcher is an entry laboratory research position, responsible for conduct of routine and standardized experiments using techniques specific to the assigned research project under the supervision of the Principal Investigator or a senior researcher. This individual assists in the interpretation of research outcomes and may be responsible for lab and clerical support. S/he analyzes and assists in interpreting research outcomes. Bachelors degree in science or related field preferred, or combination of relevant research experience and education 0-2 years of research/laboratory experience Preferred Skills Familiarity with liquid chromatography (LC) techniques. Basic understanding of organic chemistry and biochemistry. Comfortable handling organic solvents and reagents safely. Strong grasp of stoichiometry and buffer preparation. Demonstrated ability to follow detailed protocols and maintain accurate documentation. Eagerness to learn assay optimization, data interpretation, and troubleshooting. Dependable, detail-oriented, and proactive in maintaining lab operations. Execute and support experiments involving liquid chromatography (LC) and related analytical methods. Follow established assay protocols and assist in assay development and optimization. Prepare buffers, reagents, and samples accurately and safely. Maintain detailed experimental records (ELN or lab notebook). Ensure lab hygiene, organization, and safety compliance. Learn and operate new instruments, software tools, and workflows.

The Milton and Carroll Petrie Department of Urology has long been a leader in clinical practice, education, and research. Faculty in our Department, which is housed within the Icahn School of Medicine at Mount Sinai, perform complex procedures using robotics, laparoscopy, and endoscopy, all as a part of our minimally invasive urologic surgery program. We remain equally committed to engaging in breakthrough research while training the next generation of leaders in the field. The Associate Researcher is an entry laboratory research position, responsible for conduct of routine and standardized experiments using techniques specific to the assigned research project under the supervision of the Principal Investigator or a senior researcher. This individual assists in the interpretation of research outcomes and may be responsible for lab and clerical support. S/he analyzes and assists in interpreting research outcomes. Bachelors degree in science or related field preferred, or combination of relevant research experience and education 0-2 years of research/laboratory experience Under direct supervision, conducts routine and standardized experiments using appropriate research techniques specific to subject matter of the research project. Analyzes and assists in interpreting laboratory results. Performs assays to support research studies. Maintains laboratory environment and assists in the upkeep of appropriate inventory; may include ordering of supplies. Logs and tests samples; prepares and submits laboratory materials and specimens for shipment. Assists in the collection, analysis and review of experimental data for publication and presentation. Performs other related duties.

The Associate Researcher I is a laboratory research position, responsible for independent conduct of routine and standardized experiments. This individual assists in the interpretation of research outcomes, performs assays to support research studies, and assists in the clerical and supply aspects of the laboratory environment. The candidate will join the Institute for Translational Immunology & Pharmacology at the Icahn School of Medicine at Mount Sinai as an Associate Researcher. The Associate Researcher will lead a flagship project entitled “De novo Design of First-in-Class Bifunctional Small Molecules for Precision Control of T-Cell Fate via Site-Specific p53 Modification”. Bachelors or Masters degree in science or related field required No experience required. One year of research experience preferred. Leading structure-based drug design using molecular docking, long-timescale molecular dynamics, free-energy perturbation (FEP), QM/MM, and AI-guided generative models for immunomodulatory compounds. Developing and applying deep-learning / diffusion models (AlphaFold-3, RFdiffusion, geometric DL) for de novo generation and multi-parameter optimization of novel chemical scaffolds. Performing or supervising multi-step organic synthesis of top-priority candidates, followed by full analytical characterization (NMR, LC-MS, HPLC). Driving rapid design-make-test-analyze (DMTA) cycles in collaboration with medicinal chemists and immunologists to validate target engagement, selectivity, and T-cell polarization activity in primary human and murine CD4⁺ T cells. Contributing to preclinical proof-of-concept studies, including dramatic prolongation of allograft survival and suppression of EAE through Treg/effector rebalancing.

The Core Research Associate II in the Transgenic and Genome Editing Core will be responsible for various tasks related to creation, validation and cryopreservation of genetically engineered mouse models (GEMMs). Specific job duties are outlined below, and include preparation of gene editing reagents, embryo production/manipulation, implantation, post-operative care, genotyping and breeding with husbandry support from the Center for Comparative Medicine and Surgery (CCMS) group. Experience with rodent survival surgery and embryo handling is preferred but not required. Bachelors 3 years related experience (OR Masters + 1 year experience in related field) Produces mouse embryos via superovulation or natural breeding. Collects and manipulates preimplantation mouse embryos. Surgically transfers the embryos into pseudopregnant mice followed by post-operative care. Manages mouse colony via routine monitoring of mice, production of pseudopregnant females, breeding, tagging/biopsy, weaning and animal transfer. Genotypes mouse tissues utilizing PCR, sequencing and other molecular biology techniques. Assists in preparation and validation of genome editing reagents. Cryopreserves mouse sperm and/or embryos and manages the cryo-storage database. Coordinates import and export of frozen samples. Produces mouse embryos via in vitro fertilization (IVF) for line recovery/importation or genome editing. Assists in testing/implementation of new technologies. Occasional weekend work will be required. Performs other related duties as needed. Ensures rigorous compliance with safety and regulatory requirements while performing assigned tasks.

We are seeking an experienced bioinformatician for the Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) shared resource facility, to lead transcriptomics and epigenetics data analysis projects in Cancer biology. The mission of BiNGS is to enhance scholarship and facilitate NGS data analysis in the ISMMS community by providing access to state-of-the-art tools and training. The BiNGS staff support a broad range of bioinformatics analyses for multiple applications spanning bulk ATAC-, RNA-, and ChIP-seq, CUT&RUN and HiC, single cell ATAC- and RNA-seq, single cell Multiome and Spatial Transcriptomics, WGS and WES. BiNGS further provides services for data management, bioinformatics tools development, access to biocomputing resources, web-based app development, and advanced computational training in data analysis. We are focused on delivering a comprehensive, rapid and user-friendly service. More specifically, we are working on multiple projects together with PIs in the Tisch Cancer institute and the broader Mount Sinai community to analyze NGS related datasets. For example, we are working to understand the role of RAS mutations in the development of Leukemia utilizing single cell RNA- and ATAC-seq; understand the role of histone variants in cancer development utilizing enhancers analysis, transcriptomic analysis, open chromatin analysis and transcription factor network analysis; in another project, we are utilizing bulk and single cell, and spatial transcriptomics to understand breast cancer metastasis to bone. Finally, we are utilizing FIBER-seq (third generation PacBio long read sequencing), to better understand how chromatin remodelers shape the chromatin landscape. We are seeking a highly motivated senior Bioinformatic Scientist who wants the opportunity to significantly impact the growth and success of our research programs, the bioinformatics core and the services we provide. The candidate will work closely with investigators to facilitate and enhance the processing of their projects. Commitment to accuracy, high attention-to-details, and ability to work independently are critical competencies for the role. The ability to lead projects and a team of bioinformaticians is a must. We feel that BiNGS presents a unique opportunity for senior bioinformaticians who seek to expand their data analysis skills; their understanding of transcriptional and epigenetic programs and their role in driving cancer initiation, progression and metastasis, and other diseases; their ability to communicate science clearly and efficiently; their ability to lead a small team of junior of bioinformaticians, and their involvement in reducing racial bias in science through mentorship of URM in Science. **Qualifications** + M.S. in Bioinformatics, Biomedical Informatics, Computational Biology, or Genomics. Alternately, M.S. in a discipline requiring strong computational and analytical skills supplemented with some biology exposure. Ph.D in a related field preferred. Those with a Bachelors degree and additional post-graduate experience are considered. + 2+ years post-graduate experience in a research environment, including the manipulation of large biological datasets. + Advanced knowledge of genetics and/or statistical analysis software and online resources. Experience in programming environments such as MatLab, R statistical package, BioConductor, Perl and C++. Preferred Skillset + PhD in bioinformatics, computer Sciences or related fields + Proven experience in analyzing bulk RNA-seq, ATAC-seq, sc RNA-seq and Spatial transcriptomics + Proven experience with Python, R and Linux. Additional experience with standard genomics tools for high-throughput sequencing data analysis (e.g. Bowtie2, Cellranger, Samtools, STAR, MACS2 and the UCSC genome browser). Experience with markup languages such as HTML is preferred. + Proven ability to work on the AWS cloud. + Experience in bash HPC cluster environment with a parallel file system. + Proven ability to research, analyze, recommend, communicate, and implement solutions. + Good understanding of chromatin biology, and NGS technologies + Must be able to work as an individual while part of a small team. **Responsibilities** + Execute computational analysis for bulk RNA-seq, ATAC-seq, sc RNA-seq and Spatial transcriptomics using existing standard pipelines. + Tracking and reporting of ongoing projects including presentation of analysis progress in internal meetings and communications with PI to present results, interpret data and come up with new hypotheses. + Integrate data across different datatypes and from publicly available resources (e.g., ENCODE and TCGA), with experimental data generated by PIs. For example; correlation with gene expression signatures, and Histone PTM enrichment analysis. The ideal candidate will be able to navigate the available datasets and extract meaningful data based on the system he/she works on. + Provide analyses and visualization for presentations and publications. + Participate in the implementation of new software tools (e.g., MOFA and SNF) to process, analyze and visualize high-throughput multidimensional sequencing data. The candidate will be required to identify the main requirements based on relevant questions, identify available tools, implement and test. + Manage data and interactive tools on local HPC and commercially available clouds preferably Amazon Web Services. The candidate will execute all data analysis on HPC using bash and manage the storage and archiving of all NGS datasets on the MSSM HPC. Further managing of our HTML reports will be done on Amazon cloud + Provide training to TCI investigators and trainees. **About Us** **Strength through Unity and Inclusion** The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai's unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. **About the Mount Sinai Health System:** Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. **Equal Opportunity Employer** The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization. **Compensation Statement** Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $65885 - $100000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

The Center for Disease Neurogenomics (CDN) at the Icahn School of Medicine at Mount Sinai is seeking a proactive and detail-oriented Bioinformatician II to join a multidisciplinary team supporting the analysis, infrastructure, and data stewardship of large-scale functional genomics datasets. This position is intended for candidates with practical experience managing omics data, maintaining computational infrastructure, and developing efficient solutions to support high-throughput data processing and secure storage. M.S. in Bioinformatics, Biomedical Informatics, Computational Biology, or Genomics. Alternately, M.S. in a discipline requiring strong computational and analytical skills supplemented with some biology exposure. Ph.D in a related field preferred. Those with a Bachelors degree and additional post-graduate experience are considered. 2+ years post-graduate experience in a research environment, including the manipulation of large biological datasets.; with ≥3 years of experience preferred Advanced knowledge of genetics and/or statistical analysis software and online resources. Experience in programming environments such as MatLab, R statistical package, BioConductor, Perl and C++. Proficiency in Python and R; working knowledge of SQL and Linux shell scripting. Experience processing large-scale omics data (RNA-seq, ATAC-seq, or WGS). Experience using or developing Nextflow or Snakemake-based pipelines is a strong plus. Strong problem-solving skills, ability to prioritize, and attention to reproducibility and data integrity. Preferred Qualifications: Demonstrated experience maintaining or developing data tracking systems or LIMS solutions. Familiarity with HPC environments and workload managers (e.g., LSF, SLURM). Experience with cloud-based genomics analysis platforms such as CAVATICA, Verily Workbench, Google Cloud Platform (GCP), Amazon Web Services (AWS), or comparable environments. Experience with data privacy standards and compliance in biomedical datasets. Assist in the preprocessing, demultiplexing, and quality control of single-cell and bulk sequencing data across multiple assays (RNA-seq, ATAC-seq, multiome). Implement and maintain metadata infrastructure for tracking donor/sample provenance and cohort selection across projects using a relational database backend. Monitor and maintain local high-performance computing resources, including scripting of automated usage summaries, quota alerts, and issue tracking. Support data transfers, pipeline execution, and user coordination in hybrid cloud environments (e.g., CAVATICA, GCP). Write and maintain robust, well-documented code (e.g., Snakemake, bash, R, Python) for processing and managing large-scale datasets. Respond to infrastructure incidents (e.g., disk quota overflows, data loss risks) and proactively implement safeguards. Contribute to documentation and training materials to enable team-wide system usage. Other related duties as assigned.

We are seeking an experienced bioinformatician for the Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) shared resource facility, to lead transcriptomics and epigenetics data analysis projects in Cancer biology. The mission of BiNGS is to enhance scholarship and facilitate NGS data analysis in the ISMMS community by providing access to state-of-the-art tools and training. The BiNGS staff support a broad range of bioinformatics analyses for multiple applications spanning bulk ATAC-, RNA-, and ChIP-seq, CUT&RUN and HiC, single cell ATAC- and RNA-seq, single cell Multiome and Spatial Transcriptomics, WGS and WES. BiNGS further provides services for data management, bioinformatics tools development, access to biocomputing resources, web-based app development, and advanced computational training in data analysis. We are focused on delivering a comprehensive, rapid and user-friendly service. More specifically, we are working on multiple projects together with PIs in the Tisch Cancer institute and the broader Mount Sinai community to analyze NGS related datasets. For example, we are working to understand the role of RAS mutations in the development of Leukemia utilizing single cell RNA- and ATAC-seq; understand the role of histone variants in cancer development utilizing enhancers analysis, transcriptomic analysis, open chromatin analysis and transcription factor network analysis; in another project, we are utilizing bulk and single cell, and spatial transcriptomics to understand breast cancer metastasis to bone. Finally, we are utilizing FIBER-seq (third generation PacBio long read sequencing), to better understand how chromatin remodelers shape the chromatin landscape. We are seeking a highly motivated senior Bioinformatic Scientist who wants the opportunity to significantly impact the growth and success of our research programs, the bioinformatics core and the services we provide. The candidate will work closely with investigators to facilitate and enhance the processing of their projects. Commitment to accuracy, high attention-to-details, and ability to work independently are critical competencies for the role. The ability to lead projects and a team of bioinformaticians is a must. We feel that BiNGS presents a unique opportunity for senior bioinformaticians who seek to expand their data analysis skills; their understanding of transcriptional and epigenetic programs and their role in driving cancer initiation, progression and metastasis, and other diseases; their ability to communicate science clearly and efficiently; their ability to lead a small team of junior of bioinformaticians, and their involvement in reducing racial bias in science through mentorship of URM in Science. M.S. in Bioinformatics, Biomedical Informatics, Computational Biology, or Genomics. Alternately, M.S. in a discipline requiring strong computational and analytical skills supplemented with some biology exposure. Ph.D in a related field preferred. Those with a Bachelors degree and additional post-graduate experience are considered. 2+ years post-graduate experience in a research environment, including the manipulation of large biological datasets. Advanced knowledge of genetics and/or statistical analysis software and online resources. Experience in programming environments such as MatLab, R statistical package, BioConductor, Perl and C++. Preferred Skillset PhD in bioinformatics, computer Sciences or related fields Proven experience in analyzing bulk RNA-seq, ATAC-seq, sc RNA-seq and Spatial transcriptomics Proven experience with Python, R and Linux. Additional experience with standard genomics tools for high-throughput sequencing data analysis (e.g. Bowtie2, Cellranger, Samtools, STAR, MACS2 and the UCSC genome browser). Experience with markup languages such as HTML is preferred. Proven ability to work on the AWS cloud. Experience in bash HPC cluster environment with a parallel file system. Proven ability to research, analyze, recommend, communicate, and implement solutions. Good understanding of chromatin biology, and NGS technologies Must be able to work as an individual while part of a small team. Execute computational analysis for bulk RNA-seq, ATAC-seq, sc RNA-seq and Spatial transcriptomics using existing standard pipelines. Tracking and reporting of ongoing projects including presentation of analysis progress in internal meetings and communications with PI to present results, interpret data and come up with new hypotheses. Integrate data across different datatypes and from publicly available resources (e.g., ENCODE and TCGA), with experimental data generated by PIs. For example; correlation with gene expression signatures, and Histone PTM enrichment analysis. The ideal candidate will be able to navigate the available datasets and extract meaningful data based on the system he/she works on. Provide analyses and visualization for presentations and publications. Participate in the implementation of new software tools (e.g., MOFA and SNF) to process, analyze and visualize high-throughput multidimensional sequencing data. The candidate will be required to identify the main requirements based on relevant questions, identify available tools, implement and test. Manage data and interactive tools on local HPC and commercially available clouds preferably Amazon Web Services. The candidate will execute all data analysis on HPC using bash and manage the storage and archiving of all NGS datasets on the MSSM HPC. Further managing of our HTML reports will be done on Amazon cloud Provide training to TCI investigators and trainees.

We are seeking an experienced bioinformatician for the Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) shared resource facility, to lead transcriptomics and epigenetics data analysis projects in Cancer biology. The mission of BiNGS is to enhance scholarship and facilitate NGS data analysis in the ISMMS community by providing access to state-of-the-art tools and training. The BiNGS staff support a broad range of bioinformatics analyses for multiple applications spanning bulk ATAC-, RNA-, and ChIP-seq, CUT&RUN and HiC, single cell ATAC- and RNA-seq, single cell Multiome and Spatial Transcriptomics, WGS and WES. BiNGS further provides services for data management, bioinformatics tools development, access to biocomputing resources, web-based app development, and advanced computational training in data analysis. We are focused on delivering a comprehensive, rapid and user-friendly service. More specifically, we are working on multiple projects together with PIs in the Tisch Cancer institute and the broader Mount Sinai community to analyze NGS related datasets. For example, we are working to understand the role of RAS mutations in the development of Leukemia utilizing single cell RNA- and ATAC-seq; understand the role of histone variants in cancer development utilizing enhancers analysis, transcriptomic analysis, open chromatin analysis and transcription factor network analysis; in another project, we are utilizing bulk and single cell, and spatial transcriptomics to understand breast cancer metastasis to bone. Finally, we are utilizing FIBER-seq (third generation PacBio long read sequencing), to better understand how chromatin remodelers shape the chromatin landscape. We are seeking a highly motivated senior Bioinformatic Scientist who wants the opportunity to significantly impact the growth and success of our research programs, the bioinformatics core and the services we provide. The candidate will work closely with investigators to facilitate and enhance the processing of their projects. Commitment to accuracy, high attention-to-details, and ability to work independently are critical competencies for the role. The ability to lead projects is a must. We feel that BiNGS presents a unique opportunity for bioinformaticians who seek to expand their data analysis skills; their understanding of transcriptional and epigenetic programs and their role in driving cancer initiation, progression and metastasis, and other diseases; their ability to communicate science clearly and efficiently; their ability to lead a small team of junior of bioinformaticians, and their involvement in reducing racial bias in science through mentorship of URM in Science. B.S. in Biological Sciences, Bioinformatics, Computer Sciences, Statistics or related discipline; M.S. preferred 3 years experience required Working experience with genetics or statistics analysis software and online resources. Experience in programming environments such as Matlab, R statistical package, BioConductor, Perl or C++. Preferred Skillset MSc in Bioinformatics or Computational biology with a focus on genomics or related discipline. Experience in analyzing and integrating bulk RNA-seq, ATAC-seq. Knowledge of cancer biology, chromatin biology, and technologies such as next-generation sequencing. Proven experience with Perl, R and Unix. Additional experience with standard genomics tools for high-throughput sequencing data analysis is preferred (e.g. Bowtie2, Cellranger, Samtools, STAR, MACS2 and the UCSC genome browser). Experience in batch HPC cluster environment with a parallel file system. Ability to research, analyze, recommend, communicate and implement data analysis solutions. Must be able to work as an individual while part of a small team. Execute computational analysis for bulk RNA-seq, ATAC-seq, sc RNA-seq, and ChIP-seq and CUT&RUN. Tracking and reporting of ongoing projects including presentation of analysis progress in internal meetings and communications with PI to present results, interpret data and come up with new hypotheses. Integrate data across different datatypes and from publicly available resources (e.g., ENCODE and TCGA), with experimental data generated by PIs. For example; correlation with gene expression signatures, and Histone PTM enrichment analysis. The ideal candidate will be able to navigate the available datasets and extract meaningful data based on the system he/she works on. Provide analyses and visualization for presentations and publications.Participate in the implementation of new software tools (e.g., MOFA and SNF) to process, analyze and visualize high-throughput multidimensional sequencing data. The candidate will be required to identify the main requirements based on relevant questions, identify available tools, implement and test. Manage data and interactive tools on local HPC and commercially available clouds preferably Amazon Web Services. The candidate will execute all data analysis on HPC using bash and manage the storage and archiving of all NGS datasets on the MSSM HPC. Further managing of our HTML reports will be done on Amazon cloud Provide training to TCI investigators and trainees.

The Bioinformatician II partners with researchers/biologists from the Mount Sinai Department of Genetics and Genomic Sciences on innovative genomic analyses of structural variation, epigenetics, and gene expression in an integrated environment combining experimental and bioinformatic approaches to human disease. S/he leads a variety of projects and gains exposure to many productive areas of research, and develops/supports multiple research projects by delivering bioinformatics services for bio-medical data from cutting-edge genomic technologies. This incumbent performs the role of database developer for Varimpact, building a comprehensive impact database of genetic variants through text mining. This database consists of genetic variants with gene, protein, pathway, cellular, drug level functional impact and is a tool to search and highlight genetic variants, drugs and diseases in 30 million abstracts and 3 million full texts. M.S. in Bioinformatics, Biomedical Informatics, Computational Biology, or Genomics. Alternately, M.S. in a discipline requiring strong computational and analytical skills supplemented with some biology exposure. Ph.D in a related field preferred. Those with a Bachelors degree and additional post-graduate experience are considered. 2+ years post-graduate experience in a research environment, including the manipulation of large biological datasets. Advanced knowledge of genetics and/or statistical analysis software and online resources. Experience in programming environments such as MatLab, R statistical package, BioConductor, Perl and C++. Develops and may perform a lead role for a variety of bioinformatics analysis projects, including development of Varimpact, an impact database of generic variants. Writes custom scripts for analysis of genomic data derived from high-throughput techniques. Manages databases, conducts statistical and genomic analysis, and participates in the preparation of manuscripts and presentations. Collaborates with wet-bench biologists and works independently to analyze data derived from several types of projects using microarrays and high-throughput sequencing. Conducts analysis of microarray and high-throughput sequencing data, genome sequence analysis, experimental design and statistical analysis. Performs quality control and analysis. Other related duties as assigned.

How you move is why we're here. Now more than ever. Get back to what you need and love to do. The possibilities are endless... Now more than ever, our guiding principles are helping us in our search for exceptional talent - candidates who align with our unique workplace culture and who want to maximize the abundant opportunities for growth and success. If this describes you then let's talk! HSS is consistently among the top-ranked hospitals for orthopedics and rheumatology by U.S. News & World Report. As a recipient of the Magnet Award for Nursing Excellence, HSS was the first hospital in New York City to receive the distinguished designation. Whether you are early in your career or an expert in your field, you will find HSS an innovative, supportive and inclusive environment. Working with colleagues who love what they do and are deeply committed to our Mission, you too can be part of our transformation across the enterprise. Emp Status Regular Full time Work Shift Day (United States of America) Compensation Range The base pay scale for this position is $23.35 - $35.51. In addition, this position will be eligible for additional benefits consistent with the role. The salary of the finalist selected for this role will be determined based on various factors, including but not limited to: scope of role, level of experience, education, accomplishments, internal equity, budget, and subject to Fair Market Value evaluation. The hiring range listed is a good faith determination of potential compensation at the time of this job advertisement and may be modified in the future. What you will be doing Job Description: Research Technician I Department/Service: Research Institute MicroCT Imaging Core Summary: An operator of the microcomputed tomography (micro-CT) is a highly skilled professional who uses specialized micro-CT equipment. The role will involve coordination and collaboration with researchers to prepare and conduct imaging experiments on a wide range of samples and projects. Duties: * Obtaining or helping users troubleshooting imaging and initial image processing * Managing the maintenance of micro-CT equipment and analyzing computers * DATA management and DATA retrieval * Developing new methods for imaging and image processing * Training new users * Maintaining laboratory compliance with EHS Qualifications: * Prior experience in micro CT is preferred. * Able to operate sophisticated computer equipment * Strong interest in scientific and technical skills and knowledge * Able to interact compassionately and effectively with co-workers * Able to communicate effectively * Able to perform well independently * Able to follow detailed instructions * Highly self-motivated Education: * Bachelor's degree, biological or chemistry Desired Skills: * Expert level lab techniques, and research management work experience * Exceptional organizational skills * Strong written and communication skills * Proficient use of computers and software, including Microsoft Excel and Word * Prior basic science research experience preferred but not necessary Non-Discrimination Policy Hospital for Special Surgery is committed to providing high quality care and skilled, compassionate, reliable service to our community in a safe and healing environment. Consistent with this commitment, Hospital for Special Surgery provides care, admits, and treats patients and provides all services without regard to age, race, color, creed, ethnicity, religion, national origin, culture, language, physical or mental disability, socioeconomic status, veteran or military status, marital status, sex, sexual orientation, gender identity or expression, or any other basis prohibited by federal, state, or local law or by accreditation standards.