Sr Director/ Sr Principal Scientist, Protein Engineering
Senior staff scientist job at Illumina
What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.
Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.
Position Summary:
Illumina is a global leader in genomics, dedicated to advancing healthcare through continuous innovation. We are seeking a visionary leader to join our Advanced Sciences department in the area of protein engineering. Depending on experience, career aspirations, and business needs, candidates may be considered for either the Sr Director or Sr Principal Scientist role.
This role offers the opportunity to shape the future of genomics and multiomics applications, lead cutting-edge research, and collaborate across disciplines. The successful candidate will provide strategic and technical leadership for the Protein Engineering function, influencing technology roadmaps and driving the development of innovative products. The Sr Director will additionally manage the Protein Engineering function in the US.
We encourage candidates of all backgrounds and experiences to apply, including those who may not meet every requirement but are excited about the opportunity to contribute to our mission and can provide a competitive advantage in other aspects of the role.
Responsibilities:
* Shape and communicate the strategic vision for the protein engineering group, leading teams to execute on that vision.
* Evaluate product needs in the marketplace and provide strategic research direction for protein/enzyme improvements to enhance existing and novel products.
* Analyze internal and external assay capabilities to help create a market-leading product portfolio.
* Develop strategies to ensure effective and efficient achievement of company objectives for genomics and multiomics markets as they pertain to protein engineering.
* Translate strategy into executable operating plans, collaborating with peers across the organization to align and execute on strategic roadmaps.
* Establish cross-department and cross-functional collaborations to ensure project and program needs are met by the protein engineering team.
* Lead technology research and development teams in a highly matrixed organization.
* Manage and/or influence program and project leaders to ensure progress on multiple projects and programs remains on track.
* Develop and manage budgets for large capital expenditures and labor costs.
* Maintain a comprehensive understanding of NGS workflows, from sample acquisition to data analysis.
* Understand molecular details of NGS systems, including library preparation and sequencing chemistry.
* Write and review publications (e.g., marketing collateral, scientific papers) and present to the Illumina executive team, board of directors, and at scientific conferences.
Listed responsibilities are not an exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs
Requirements:
* Expertise in the latest protein engineering techniques and methods; familiarity with DNA polymerases, transposases, reverse transcriptases, nanopores and other nucleic acid binding or modifying enzymes.
* Demonstrated leadership skills with a track record of developing and mentoring senior leaders and individual contributors in diverse contexts.
* Deep knowledge of Next Generation Sequencing (NGS) and hands-on experience with library preparation for Illumina sequencing systems or other sequencing technologies.
* Experience in taking conceptual research through development to a viable product for commercialization.
* Strong program and project management skills, including scope, scheduling, budget, and resource management.
* Excellent presentation skills for diverse audiences.
All listed requirements are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional task and responsibilities.
Experience/Education:
* PhD in Biological Sciences, Chemical Biology or equivalent experience.
* Typically requires a Bachelor's degree and a minimum of 20 years of related experience, with 12+ years of Management experience.
* Experience managing and mentoring senior-level PhD scientists across various disciplines while overseeing product development projects.
* Broad knowledge of all areas within protein engineering.
* Deep technical knowledge in a variety of functions, gained from experience in both non-management and management roles.
If you are passionate about advancing science and technology, and excited to contribute to Illumina's mission, we encourage you to apply, even if your experience doesn't precisely match every requirement. We look forward to learning how your unique background and perspective can help us unlock the power of the genome.
The estimated base salary range for the Sr Director/ Sr Principal Scientist, Protein Engineering role based in the United States of America is: $220,500 - $330,700. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. Compensation decisions are dependent on several factors including, but not limited to, an individual's qualifications, location where the role is to be performed, internal equity, and alignment with market data. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.
We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact accommodations@illumina.com. To learn more, visit: ****************************************************************** The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants.
Auto-ApplySr Principal Scientist-Pathologist / Head of TS Digital Pathology Analytics
South San Francisco, CA jobs
** ** A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech, a member of the Roche Group.
**The Opportunity**
The Head of Translational Safety (TS) Digital Pathology Analytics provides the strategic vision, scientific and technical direction, and operational leadership for the Translational Safety Digital Pathology group. The successful Sr Principal Sci-Pathologist candidate will lead efforts focused on driving applications for digital pathology in the field of toxicologic pathology and predictive nonclinical safety evaluation, thereby contributing to the efficient, comprehensive, and integrated safety profiling of Genentech drug candidates from the Research stage through marketed products. This includes managing a team of AI/ML scientists to create and implement novel, state-of-the-art analytical and computational approaches aimed at improving the efficiency of pathology workflows and enhancing the acquisition and interpretation of high-quality quantitative morphologic data obtained from in vivo studies and in vitro methodologies. This position is also responsible for engaging and directing cross-functional digital pathology collaborations throughout the Genentech/Roche organization.
**In this role, you will:**
+ Manage strategy and team to advance digital pathology efforts to achieve TS, gRED, and Roche-wide cross-functional goals
+ Collaborate with project pathologists and toxicologists to align digital pathology goals with the evolving therapeutic portfolio
+ Represent TS as a primary gRED digital pathology contact for fostering collaboration and coordination on decisions with global organization-wide impact and significance
+ Influence the informatics and computational strategies across the global Roche organization and drive highly impactful initiatives internally and externally
+ Budget and resource planning responsibility (horizon of ~1 year), including the evaluation and application of emerging technologies (hardware and software)
+ Manage 5-10 FTEs or contractors
**Who you are**
+ D.V.M. and Ph.D. or equivalent curriculum. Diplomate in either the American or European College of Veterinary Pathology
+ Expertise in the application of digital pathology, image analysis, machine learning, and/or computer vision to pathology and biology
+ 10+ years of relevant drug development experience and at least 4 years of management experience
+ Demonstrated outstanding leadership and effective management in scientific, technical, and/or operational areas, with the ability to lead toward organizational goals across functions
+ Strong reputation as a manager and mentor
+ Sustained record of impactful performance, strategic insight in advancing drug development
This role will be based in South San Francisco, and relocation benefits are available
The expected salary range for this position, based on the primary location of California, is $198,900 - $369,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits (****************************************************
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .
Principal Scientist, Group Leader, Antibody Engineering
South San Francisco, CA jobs
** **The Opportunity** We are seeking an exceptional Principal Scientist (Group Leader) to join our world-class Antibody Engineering Department, where we discover and engineer life-changing antibody drugs through pioneering science and technology. The successful candidate will lead a scientific team to enhance existing platforms and develop novel technologies to expand our pipeline of antibody-based drugs across therapeutic areas.
You will focus on these areas
+ Contribute to research at the interface between technology and biology
+ Define important therapeutic problems in collaboration with Genentech's therapeutic areas
+ Drive innovation to solve them through antibody engineering
Our new Scientist/Group Lead will help shape the future of our antibody drug capabilities and will be expected to present their research externally and publish in peer-reviewed journals. The hire will work collaboratively in a multi-disciplinary team environment to design, validate, and advance next generation biologics that address major unmet medical needs into clinical development. We are seeking highly motivated and self-driven candidates with a passion for innovation, creativity, and commitment to translational science and drug development.
**Who You Are**
+ PhD in a biological science, complemented by postdoctoral training or 4+ years recent equivalent antibody engineering in academia, biotechnology and/or pharma.
+ We encourage applications from candidates with extensive prior experience as well as those coming directly from exemplary postdoc careers.
+ The successful candidate will have demonstrated a sustained record of productivity and substantive scientific contributions as determined by consistent high-impact publications, patent inventorship, and/or external presentations.
+ Candidates need to be team-oriented, collegial, and have strong interpersonal and communication skills.
**Preferred**
+ Ideal applicants will excel in protein engineering methodologies and be well-versed in biology.
+ Experience with engineering bi- or multi-specific antibody/protein formats is preferred.
+ Experience with structure-based protein analysis is a plus.
+ Research experience with antibodies is preferred but is not essential.
Relocation benefits are available for this job posting.
The expected salary range for this position based on the primary location of California is $143,200 to $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
**Benefits (******************************************************
\#LI-KC2
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .
Lab Head, Principal Scientist, Discovery Oncology
South San Francisco, CA jobs
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech.
The Opportunity
The Department of Discovery Oncology at Genentech is thrilled to announce a unique opportunity for a highly skilled, highly motivated Principal Scientist to lead a lab-based research group. We seek an exceptional candidate with expertise in the biology of hormone-dependent cancers, specifically of the breast and prostate, who will be dedicated to discovering and developing new therapies.
The successful candidate will work closely with our Drug Development, Translational Medicine, Computational and Clinical Science colleagues to formulate new therapeutic hypotheses and to advance transformative medicines. This is a particularly exciting time to join the team, as we build considerable momentum with a rich portfolio of breast and prostate cancer programs.
Key responsibilities include:
Research Leadership: Lead and manage a high-performing team that discovers novel targets and/or progresses cutting-edge therapies in hormone-dependent cancers.
Interdisciplinary Collaboration: Work closely with internal experts across departments and disciplines to drive innovative therapeutic strategies.
Innovative Drug Discovery: Leverage advanced tools and approaches to identify new targets and/or advance the targeting of biological axes known to be critical for tumors.
Translational Impact: Generate high-quality, original research that advances our understanding of hormone-dependent cancer biology and therapeutics.
Communication and Collaboration: Foster a collaborative environment and ensure that data-driven insights are effectively translated into actionable drug discovery and clinical strategies.
Who You Are
Educational Background: Ph.D. in Biochemistry, Cell Biology, or a closely related field.
Experience: Minimum 4 years post-Ph.D. of productive postdoctoral training and/or industry experience. Your record should reflect high-impact publications, patents, and/or successful project transitions.
Technical Expertise: Demonstrated expertise in breast or prostate cancer research, encompassing biochemical, molecular and/or cell biology approaches.
Leadership and Collaboration: Exceptional leadership potential and a track record of working with multidisciplinary teams, excellent written and verbal communication skills, and a collaborative spirit.
Preferreds
Familiarity with leading-edge drug discovery approaches (e.g. molecular glues, induced proximity) would be advantageous.
Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $143,200 to $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
#LI-KC2
#gRED
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Auto-ApplyPrincipal Scientist, Group Leader, Antibody Engineering
South San Francisco, CA jobs
The Opportunity We are seeking an exceptional Principal Scientist (Group Leader) to join our world-class Antibody Engineering Department, where we discover and engineer life-changing antibody drugs through pioneering science and technology. The successful candidate will lead a scientific team to enhance existing platforms and develop novel technologies to expand our pipeline of antibody-based drugs across therapeutic areas.
You will focus on these areas
* Contribute to research at the interface between technology and biology
* Define important therapeutic problems in collaboration with Genentech's therapeutic areas
* Drive innovation to solve them through antibody engineering
Our new Scientist/Group Lead will help shape the future of our antibody drug capabilities and will be expected to present their research externally and publish in peer-reviewed journals. The hire will work collaboratively in a multi-disciplinary team environment to design, validate, and advance next generation biologics that address major unmet medical needs into clinical development. We are seeking highly motivated and self-driven candidates with a passion for innovation, creativity, and commitment to translational science and drug development.
Who You Are
* PhD in a biological science, complemented by postdoctoral training or 4+ years recent equivalent antibody engineering in academia, biotechnology and/or pharma.
* We encourage applications from candidates with extensive prior experience as well as those coming directly from exemplary postdoc careers.
* The successful candidate will have demonstrated a sustained record of productivity and substantive scientific contributions as determined by consistent high-impact publications, patent inventorship, and/or external presentations.
* Candidates need to be team-oriented, collegial, and have strong interpersonal and communication skills.
Preferred
* Ideal applicants will excel in protein engineering methodologies and be well-versed in biology.
* Experience with engineering bi- or multi-specific antibody/protein formats is preferred.
* Experience with structure-based protein analysis is a plus.
* Research experience with antibodies is preferred but is not essential.
Relocation benefits are available for this job posting.
The expected salary range for this position based on the primary location of California is $143,200 to $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
#LI-KC2
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Senior Principal Scientist, Peptide Therapeutics
South San Francisco, CA jobs
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech.
The Opportunity
We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team. This is a technical leadership position within our Peptide Therapeutics department, focused on advancing Peptide Therapeutics.
The ideal candidate will be a significant contributor and a proven leader, responsible for optimizing and advancing novel peptide therapeutics into clinical development. You will lead the Medicinal Chemistry efforts for a highly integrated and collaborative team, applying your deep scientific expertise to solve complex drug discovery challenges and drive projects forward.
Key Responsibilities
Drive the discovery of novel peptide therapeutics. Govern the design and synthesis of innovative peptides and peptidomimetics with enhanced potency, stability, and pharmacokinetic properties.
Lead scientific and project teams from concept to clinic. Initiate and lead new research projects, guiding them from early hit identification through lead optimization, with the ultimate goal of advancing promising compounds to clinical development.
Implement rational drug design strategies. Apply a broad repertoire of skills, including peptide synthesis, conformational analysis, and computational methods to implement strategic structure-activity relationship plans that optimize the pharmaceutical properties of peptide leads.
Champion cross-functional collaboration. Lead or co-lead multidisciplinary teams, serving as a key scientific partner to colleagues in Research Biology and Drug Discovery to overcome complex challenges associated with the development of peptide therapeutics.
Provide scientific leadership and mentorship. Supervise and mentor junior scientists, contribute to the prioritization of team objectives, and propose future strategies to meet broader portfolio goals.
Ensure data integrity and project success. Oversee the analysis and interpretation of complex analytical data, including mass spectrometry, HPLC, and NMR, to confirm compound identity and purity. You will be responsible for managing multiple projects simultaneously, delivering high-quality results on time.
Who You Are
Education: Ph.D. or postdoctoral degree in Organic Chemistry, Medicinal Chemistry, or a related field.
Experience: A minimum of 7 years of experience in the biotechnology or pharmaceutical industry, with a proven track record of advancing drug candidates from the conceptual stage into clinical testing.
Technical Expertise:
Demonstrated mastery in complex molecule organic synthesis, including proficiency in both automated solid-phase peptide synthesis, and solution-phase small molecule synthesis, utilizing state-of-the-art protecting group and purification strategies.
Must possess expertise in high-throughput and parallel synthesis for library generation, coupled with the expert ability to analyze and interpret all relevant analytical data (HPLC, Mass Spectrometry, NMR) to confirm the identity and purity of all synthesized drug candidates.
Required experience in designing, developing, and implementing novel synthetic routes to overcome challenging chemical and physicochemical issues associated with optimizing both peptide and small molecule scaffolds.
Must possess deep experience in the design and multi-step synthesis of novel, non-commercial building blocks and scaffolds to enable SAR exploration and overcome property liabilities.
Deep knowledge of macrocyclic peptides, including the properties required for different routes of administration (i.e. IV vs SC vs PO, etc), and related library-based screening technologies (e.g., OBOC, mRNA display, AS/MS).
Computational Methods:
Experience with computational modeling and simulation for peptide design and optimization, including conformational sampling and molecular dynamics (MD) simulations.
Proficiency in structure-based drug design and ligand-based drug design to guide peptide modifications.
Familiarity with machine learning and AI-driven platforms for predicting peptide properties, optimizing sequences, and generating novel scaffolds.
Experience using common computational chemistry software (e.g., Schrödinger, MOE, Maestro, or similar).
Leadership & Collaboration:
Demonstrated success in a leadership role, guiding multidisciplinary teams to deliver drug candidates.
Exceptional communication and presentation skills, with the ability to inspire and lead within a globally matrixed organization.
A highly collaborative and transparent style, with a proven ability to mentor junior scientists and build strong relationships across all levels of the organization.
Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $168,600 to $313,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
#LI-KC2
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Auto-ApplySenior Principal Scientist, Peptide Therapeutics
South San Francisco, CA jobs
** A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech.
**The Opportunity**
We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team. This is a technical leadership position within our Peptide Therapeutics department, focused on advancing Peptide Therapeutics.
The ideal candidate will be a significant contributor and a proven leader, responsible for optimizing and advancing novel peptide therapeutics into clinical development. You will lead the Medicinal Chemistry efforts for a highly integrated and collaborative team, applying your deep scientific expertise to solve complex drug discovery challenges and drive projects forward.
Key Responsibilities
+ Drive the discovery of novel peptide therapeutics. Govern the design and synthesis of innovative peptides and peptidomimetics with enhanced potency, stability, and pharmacokinetic properties.
+ Lead scientific and project teams from concept to clinic. Initiate and lead new research projects, guiding them from early hit identification through lead optimization, with the ultimate goal of advancing promising compounds to clinical development.
+ Implement rational drug design strategies. Apply a broad repertoire of skills, including peptide synthesis, conformational analysis, and computational methods to implement strategic structure-activity relationship plans that optimize the pharmaceutical properties of peptide leads.
+ Champion cross-functional collaboration. Lead or co-lead multidisciplinary teams, serving as a key scientific partner to colleagues in Research Biology and Drug Discovery to overcome complex challenges associated with the development of peptide therapeutics.
+ Provide scientific leadership and mentorship. Supervise and mentor junior scientists, contribute to the prioritization of team objectives, and propose future strategies to meet broader portfolio goals.
+ Ensure data integrity and project success. Oversee the analysis and interpretation of complex analytical data, including mass spectrometry, HPLC, and NMR, to confirm compound identity and purity. You will be responsible for managing multiple projects simultaneously, delivering high-quality results on time.
**Who You Are**
+ Education: Ph.D. or postdoctoral degree in Organic Chemistry, Medicinal Chemistry, or a related field.
+ Experience: A minimum of 7 years of experience in the biotechnology or pharmaceutical industry, with a proven track record of advancing drug candidates from the conceptual stage into clinical testing.
Technical Expertise:
+ Demonstrated mastery in complex molecule organic synthesis, including proficiency in both automated solid-phase peptide synthesis, and solution-phase small molecule synthesis, utilizing state-of-the-art protecting group and purification strategies.
+ Must possess expertise in high-throughput and parallel synthesis for library generation, coupled with the expert ability to analyze and interpret all relevant analytical data (HPLC, Mass Spectrometry, NMR) to confirm the identity and purity of all synthesized drug candidates.
+ Required experience in designing, developing, and implementing novel synthetic routes to overcome challenging chemical and physicochemical issues associated with optimizing both peptide and small molecule scaffolds.
+ Must possess deep experience in the design and multi-step synthesis of novel, non-commercial building blocks and scaffolds to enable SAR exploration and overcome property liabilities.
+ Deep knowledge of macrocyclic peptides, including the properties required for different routes of administration (i.e. IV vs SC vs PO, etc), and related library-based screening technologies (e.g., OBOC, mRNA display, AS/MS).
Computational Methods:
+ Experience with computational modeling and simulation for peptide design and optimization, including conformational sampling and molecular dynamics (MD) simulations.
+ Proficiency in structure-based drug design and ligand-based drug design to guide peptide modifications.
+ Familiarity with machine learning and AI-driven platforms for predicting peptide properties, optimizing sequences, and generating novel scaffolds.
+ Experience using common computational chemistry software (e.g., Schrödinger, MOE, Maestro, or similar).
Leadership & Collaboration:
+ Demonstrated success in a leadership role, guiding multidisciplinary teams to deliver drug candidates.
+ Exceptional communication and presentation skills, with the ability to inspire and lead within a globally matrixed organization.
+ A highly collaborative and transparent style, with a proven ability to mentor junior scientists and build strong relationships across all levels of the organization.
Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $168,600 to $313,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
**Benefits (******************************************************
\#LI-KC2
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .
Senior Principal Scientist, Peptide Therapeutics
South San Francisco, CA jobs
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Genentech.
The Opportunity
We are seeking a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team. This is a technical leadership position within our Peptide Therapeutics department, focused on advancing Peptide Therapeutics.
The ideal candidate will be a significant contributor and a proven leader, responsible for optimizing and advancing novel peptide therapeutics into clinical development. You will lead the Medicinal Chemistry efforts for a highly integrated and collaborative team, applying your deep scientific expertise to solve complex drug discovery challenges and drive projects forward.
Key Responsibilities
* Drive the discovery of novel peptide therapeutics. Govern the design and synthesis of innovative peptides and peptidomimetics with enhanced potency, stability, and pharmacokinetic properties.
* Lead scientific and project teams from concept to clinic. Initiate and lead new research projects, guiding them from early hit identification through lead optimization, with the ultimate goal of advancing promising compounds to clinical development.
* Implement rational drug design strategies. Apply a broad repertoire of skills, including peptide synthesis, conformational analysis, and computational methods to implement strategic structure-activity relationship plans that optimize the pharmaceutical properties of peptide leads.
* Champion cross-functional collaboration. Lead or co-lead multidisciplinary teams, serving as a key scientific partner to colleagues in Research Biology and Drug Discovery to overcome complex challenges associated with the development of peptide therapeutics.
* Provide scientific leadership and mentorship. Supervise and mentor junior scientists, contribute to the prioritization of team objectives, and propose future strategies to meet broader portfolio goals.
* Ensure data integrity and project success. Oversee the analysis and interpretation of complex analytical data, including mass spectrometry, HPLC, and NMR, to confirm compound identity and purity. You will be responsible for managing multiple projects simultaneously, delivering high-quality results on time.
Who You Are
* Education: Ph.D. or postdoctoral degree in Organic Chemistry, Medicinal Chemistry, or a related field.
* Experience: A minimum of 7 years of experience in the biotechnology or pharmaceutical industry, with a proven track record of advancing drug candidates from the conceptual stage into clinical testing.
Technical Expertise:
* Demonstrated mastery in complex molecule organic synthesis, including proficiency in both automated solid-phase peptide synthesis, and solution-phase small molecule synthesis, utilizing state-of-the-art protecting group and purification strategies.
* Must possess expertise in high-throughput and parallel synthesis for library generation, coupled with the expert ability to analyze and interpret all relevant analytical data (HPLC, Mass Spectrometry, NMR) to confirm the identity and purity of all synthesized drug candidates.
* Required experience in designing, developing, and implementing novel synthetic routes to overcome challenging chemical and physicochemical issues associated with optimizing both peptide and small molecule scaffolds.
* Must possess deep experience in the design and multi-step synthesis of novel, non-commercial building blocks and scaffolds to enable SAR exploration and overcome property liabilities.
* Deep knowledge of macrocyclic peptides, including the properties required for different routes of administration (i.e. IV vs SC vs PO, etc), and related library-based screening technologies (e.g., OBOC, mRNA display, AS/MS).
Computational Methods:
* Experience with computational modeling and simulation for peptide design and optimization, including conformational sampling and molecular dynamics (MD) simulations.
* Proficiency in structure-based drug design and ligand-based drug design to guide peptide modifications.
* Familiarity with machine learning and AI-driven platforms for predicting peptide properties, optimizing sequences, and generating novel scaffolds.
* Experience using common computational chemistry software (e.g., Schrödinger, MOE, Maestro, or similar).
Leadership & Collaboration:
* Demonstrated success in a leadership role, guiding multidisciplinary teams to deliver drug candidates.
* Exceptional communication and presentation skills, with the ability to inspire and lead within a globally matrixed organization.
* A highly collaborative and transparent style, with a proven ability to mentor junior scientists and build strong relationships across all levels of the organization.
Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $168,600 to $313,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
#LI-KC2
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Scientist II, Bioinformatics
Menlo Park, CA jobs
PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.
We are seeking a computational scientist to develop and apply long-read sequencing methods in cancer research and human genomics. In this role, you will build software that enables streamlined analysis of PacBio HiFi data, including secondary analysis tools and production pipelines; run large-scale genomic workflows; and interpret results from diverse datasets. You will collaborate closely with internal teams and a broad range of external partners, contribute to our scientific mission, and help drive new insights through HiFi data. We are looking for someone who is thoughtful, motivated to tackle challenging problems, and adaptable enough to work on projects spanning product development and applied research.
Responsibilities:
Build reliable, well-tested bioinformatic software and end-to-end analysis pipelines
Apply bioinformatic tools to answer biological questions related to human health, including cancer and rare disease
Collaborate with external partners in both academia and industry, supporting and leading projects
Benchmark and evaluate bioinformatic methods
Communicate scientific findings through oral and written formats, including papers, posters, and
talks at national and international scientific conferences
Required Qualifications:
Ph.D. in a computational or biological field (e.g., bioinformatics, genetics, genomics, computer science)
Strong programming skills in Rust, Python, or C++
Proficiency in analyzing large-scale sequencing datasets (e.g., genomics, transcriptomics, epigenomics, genome assemblies)
Foundational understanding of cancer genetics, human genomics, or RNA biology, with interest in developing deep expertise in these areas
Basic statistical skills for analyzing large datasets, including visualization, modeling, and quality control
Track record of scientific publishing, including first-author manuscripts
Excellent interpersonal, written, and verbal communication skills
Preferred Experience:
Experience working within large scientific consortia and collaborating closely with both wet-lab and computational teams
Demonstrated ability to develop and maintain analysis pipelines using WDL or Snakemake
Experience building and deploying containerized software (e.g., Docker or Singularity)
Familiarity with modern software development practices
Candidates must have current authorization to work in the United States without the need for present or future sponsorship.
Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home). Depending on the role, some employees may be required to be 100% onsite.
You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.
All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
#LI-Onsite
Salary Range:
$128,800.00 - $193,200.00
To all Staffing and Recruiting Agencies: Our Careers Site is only for individuals seeking a job at PacBio. Staffing and recruiting agencies and individuals being represented by an agency are not authorized to use this site or to submit profiles, applications or resumes, and any such submissions will be considered unsolicited. PacBio does not accept unsolicited resumes or applications from agencies. Please do not forward resumes to our jobs alias, PacBio employees or any other company location. PacBio is not responsible for any fees related to unsolicited resumes/applications.
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at ************, or ****************************** for assistance.
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Auto-ApplyTechnical Development Principal Scientist - Bioconjugation
South San Francisco, CA jobs
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche!
As part of Pharma Technical Development (PTD) our organization is committed to deliver the Pharma ambitions by bringing game-changing therapies from clinical phase I into the market to serve every patient, every day. Our core business is to develop safe, innovative and effective drugs using cutting edge technologies for manufacturing process (Drug Substance and Drug Product), clinical supply, formulation, device, packaging, and analytical development.
Together with our partners, Global Biologics Bioprocess Development develops robust, efficient, and sustainable bioprocesses including Cell Line & Media Development, Cell Culture & Fermentation, and Purification Development.
The Opportunity
We are seeking a highly motivated and accomplished bio-conjugation scientist to join our team within Purification Development. This is an exceptional opportunity to contribute to the development and scale-up of conjugation processes for Antibody Drug Conjugates (ADCs) and other innovative bioconjugates platforms.
As a subject matter expert in multiple conjugation chemistries, you will play a pivotal role, working collaboratively with cross-functional CMC (Chemistry, Manufacturing, and Controls) teams, research and manufacturing partners. Your expertise will be instrumental in the development, validation, and manufacturing of clinical and commercial bioconjugate pharmaceuticals that can transform patient lives.
Responsibilities
* Lead Bioconjugation Process Development: Define strategy and lead the design, execution, analysis, and documentation of experiments to develop scalable, manufacturable bioconjugation processes and subsequent purification workflows.
* Drive Innovation: Apply innovative thinking and deep understanding of conjugation and chemistry/biochemistry expertise to establish novel methodologies for the manufacturing and characterization of bioconjugate pharmaceuticals.
* Lead as a Subject Matter Expert: Serve as a departmental expert in conjugation chemistry and other related organic and biochemistry topics to provide technical expertise to guide decision making during drug development
* Communicate Scientific Advancements: Effectively present data at internal scientific and governance forums and external conferences
* Author Critical Documentation: Author technical reports, experimental protocols, validation reports, and key sections in regulatory filings
* Collaboration: Work closely with Technical Development Teams to develop and manufacture bioconjugates. Represent the organization in cross-functional meetings with internal Research and Manufacturing groups and with external partners and CMOs.
Who you are
Required Experience
* Education: B.S./M.S. with 10+ years of relevant experience, or a Ph.D with 5+ years of relevant experience. in Chemistry, Biochemistry, Chemical Engineering, Bioengineering, or a closely related field.
* Industry Experience: Relevant experience within large or small molecule CMC organizations (analytical, purification, or related) in the healthcare, biotech, or pharmaceutical industry
* Conjugation Expertise:Extensive hands-on experience with chemical and enzymatic conjugation chemistries, including small-molecule linker-payload systems and other conjugatable payloads. Skilled in diverse linker-drug conjugation and cleavage mechanisms, with a track record of translating small-scale bioconjugation techniques into scalable, manufacturing-ready processes.
* Bioconjugate Characterization: Strong technical proficiency in bioconjugate characterization using LC-MS, along with experience in key analytical techniques such as SEC, HIC, and RP-LC.
* Regulatory Filings: Experience with authoring regulatory-facing documents
Preferred Experience
* Experience and understanding of protein purification and characterization methods
* Experience with process validation
Candidate Skills
* Strong work ethic, must be self-motivated, flexible, able to multitask, and meet timelines efficiently and productively
* Excellent written and verbal communication and interpersonal skills, with a demonstrated ability to collaborate effectively with multidisciplinary teams.
* Strong use of critical thinking to design, analyze, and troubleshoot experiments
* Ability to translate scientific literature in practical solutions
* Ability to lead teams to achieve goals and represent the department in cross-functional project teams. Expected to provide significant data and technical insights to project teams.
Relocation benefits are not available for this job posting.
The expected salary range for this position based on the primary location of South San Francisco, CA is $120,800 to $224,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Technical Development Staff Scientist
South San Francisco, CA jobs
As part of Pharma Technical Development (PTD) our organization is committed to deliver the Pharma ambitions by bringing game-changing therapies from clinical phase I into the market to serve every patient, every day. Our core business is to develop safe, innovative and effective drugs using cutting edge technologies for manufacturing process (Drug Substance and Drug Product), clinical supply, formulation, device, packaging, and analytical development.
Together with our partners, Global Biologics Bioprocess Development develops robust, efficient, and sustainable bioprocesses including Cell Line & Media Development, Cell Culture & Fermentation, and Purification Development.
The Cell Culture Development US organization provides innovative technologies and strategic support for development and commercialization of Genentech and Roche's biologic portfolio, including standard monoclonal antibodies as well as complex and modified proteins such as antibody drug conjugates and bispecific antibodies. The Roche/Genentech biological portfolio spans late stage research (LSR), preclinical, clinical, and initial marketing authorization.
The department of Cell Culture and Bioprocess Operations (CCBO) within Genentech's Pharma Technical Development (PTD) organization is seeking a highly experienced and self-motivated senior-level scientist to lead cell culture media development efforts for a diverse range of biological products.
The ideal candidate for this role will have extensive cell culture media development experience and demonstrated strengths in fostering teamwork and collaboration with an inclusive mindset.
The Opportunity
The successful candidate will lead media development for mammalian cell lines expressing therapeutic antibodies, bispecific antibodies, complex biologics and other new modalities including gene and cell therapies. The successful candidate will provide scientific and strategic guidance to establish highly-productive next-generation platform processes in collaboration with multiple stakeholders within and outside CCBO/PTD. This position requires a passion for scientific rigor and excellent skills in leadership, communication, strategic thinking, decision making, influencing, and problem solving. The location for this role is our US Headquarters in South San Francisco, CA.
Responsibilities
Develop chemically-defined cell culture media to meet different needs, including high-density cultures for biologics manufacturing, and cell-based therapies.
Innovate, define strategies, and apply advanced technologies to improve cell culture performance and establish next-generation platform processes.
Serve as primary in-house expert for state-of-the-art practice in media development.
Provide technical leadership and strategic guidance to support technical/product teams, media preparation operations, raw material assessments, and supply chain updates.
Guide, motivate, and develop staff in the Media and Process Group (MPG) within CCBO, with emphasis on defining their technical priorities and focus.
Cultivate a lean mindset with focus on simplification and continuous improvement.
Interface effectively within CCBO department and PTD, as well as with other internal Genentech/Roche organizations and external collaborators.
Anticipate, identify, and resolve issues, with escalation and stakeholder communication where appropriate.
Exert influence inside and outside the company through presentations, publications, and participation in meetings.
Who you are
The successful candidate will have an established track record for strong technical leadership in cell culture media development. Other requirements for this role include:
PhD (biological sciences, chemical engineering or related discipline) with 10+ years of relevant work experience OR BS/MS (biological sciences, chemical engineering or related discipline) with 14+ years of relevant work experience.
Solid understanding of cell metabolism and tools for metabolic pathway analyses.
Expertise in using computational methods, metabolic models, statistical design of experiments, -omics, and other current technologies to improve cell culture processes.
Prior experience in media development for mammalian cell cultures.
Prior experience in technology transfer and development of cell-based therapies is a plus.
Demonstrated ability to lead and drive technical projects to completion through scientific rigor and strong organization skills.
Proven track record of managing and developing highly productive technical teams with an inclusive mindset.
Proven track record of building and maintaining strong relationships with partners, customers, and collaborators.
Proven track record of excellent verbal and written communication through conference presentations and publications.
This is an onsite position based out of South San Francisco, California, USA.
Relocation benefits are available for this position.
The expected salary range for this position based on the primary location of South San Francisco, CA is $180,700 to $335,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Auto-ApplyTechnical Development Staff Scientist
South San Francisco, CA jobs
As part of Pharma Technical Development (PTD) our organization is committed to deliver the Pharma ambitions by bringing game-changing therapies from clinical phase I into the market to serve every patient, every day. Our core business is to develop safe, innovative and effective drugs using cutting edge technologies for manufacturing process (Drug Substance and Drug Product), clinical supply, formulation, device, packaging, and analytical development.
Together with our partners, Global Biologics Bioprocess Development develops robust, efficient, and sustainable bioprocesses including Cell Line & Media Development, Cell Culture & Fermentation, and Purification Development.
The Cell Culture Development US organization provides innovative technologies and strategic support for development and commercialization of Genentech and Roche's biologic portfolio, including standard monoclonal antibodies as well as complex and modified proteins such as antibody drug conjugates and bispecific antibodies. The Roche/Genentech biological portfolio spans late stage research (LSR), preclinical, clinical, and initial marketing authorization.
The department of Cell Culture and Bioprocess Operations (CCBO) within Genentech's Pharma Technical Development (PTD) organization is seeking a highly experienced and self-motivated senior-level scientist to lead cell culture media development efforts for a diverse range of biological products.
The ideal candidate for this role will have extensive cell culture media development experience and demonstrated strengths in fostering teamwork and collaboration with an inclusive mindset.
The Opportunity
The successful candidate will lead media development for mammalian cell lines expressing therapeutic antibodies, bispecific antibodies, complex biologics and other new modalities including gene and cell therapies. The successful candidate will provide scientific and strategic guidance to establish highly-productive next-generation platform processes in collaboration with multiple stakeholders within and outside CCBO/PTD. This position requires a passion for scientific rigor and excellent skills in leadership, communication, strategic thinking, decision making, influencing, and problem solving. The location for this role is our US Headquarters in South San Francisco, CA.
Responsibilities
* Develop chemically-defined cell culture media to meet different needs, including high-density cultures for biologics manufacturing, and cell-based therapies.
* Innovate, define strategies, and apply advanced technologies to improve cell culture performance and establish next-generation platform processes.
* Serve as primary in-house expert for state-of-the-art practice in media development.
* Provide technical leadership and strategic guidance to support technical/product teams, media preparation operations, raw material assessments, and supply chain updates.
* Guide, motivate, and develop staff in the Media and Process Group (MPG) within CCBO, with emphasis on defining their technical priorities and focus.
* Cultivate a lean mindset with focus on simplification and continuous improvement.
* Interface effectively within CCBO department and PTD, as well as with other internal Genentech/Roche organizations and external collaborators.
* Anticipate, identify, and resolve issues, with escalation and stakeholder communication where appropriate.
* Exert influence inside and outside the company through presentations, publications, and participation in meetings.
Who you are
The successful candidate will have an established track record for strong technical leadership in cell culture media development. Other requirements for this role include:
* PhD (biological sciences, chemical engineering or related discipline) with 10+ years of relevant work experience OR BS/MS (biological sciences, chemical engineering or related discipline) with 14+ years of relevant work experience.
* Solid understanding of cell metabolism and tools for metabolic pathway analyses.
* Expertise in using computational methods, metabolic models, statistical design of experiments, -omics, and other current technologies to improve cell culture processes.
* Prior experience in media development for mammalian cell cultures.
* Prior experience in technology transfer and development of cell-based therapies is a plus.
* Demonstrated ability to lead and drive technical projects to completion through scientific rigor and strong organization skills.
* Proven track record of managing and developing highly productive technical teams with an inclusive mindset.
* Proven track record of building and maintaining strong relationships with partners, customers, and collaborators.
* Proven track record of excellent verbal and written communication through conference presentations and publications.
This is an onsite position based out of South San Francisco, California, USA.
Relocation benefits are available for this position.
The expected salary range for this position based on the primary location of South San Francisco, CA is $180,700 to $335,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Senior Machine Learning Scientist, BRAID (Clinical Sciences ML)
South San Francisco, CA jobs
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche.
Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche's Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide.
The Opportunity
Genentech is seeking an exceptional Senior Machine Learning Scientist to join the BRAID (Biology Research | AI Development) team within our Computational Sciences organization. This role will focus on developing novel machine learning methods to transform clinical trial design and translational medicine, with a strong emphasis on foundation models for clinical genomics and real-world data. You will work at the intersection of machine learning, omics (DNA, RNA), and EHR data, advancing algorithms that integrate biological and clinical modalities to improve patient stratification, target selection, and treatment outcomes. The ideal candidate will possess in-depth expertise in modern machine learning approaches (e.g., transformer-based models, generative modeling, representation learning) and a track record of impactful research in clinical genomics or multimodal biomedical data analysis. A passion for interdisciplinary collaboration and a commitment to open scientific communication are essential.
In this role, you will:
Design and implement novel machine learning algorithms tailored to the complexities of clinical trial data (e.g., sequence models for patient omics data).
Collaborate with cross-functional teams including biologists, clinicians, data scientists, and other stakeholders to integrate machine learning solutions into clinical decision-making.
Work closely with biologists, clinicians, and translational scientists to develop clinically meaningful AI tools that integrate molecular signatures, patient trajectories, and trial outcomes.
Analyze large-scale datasets including whole transcriptome, whole exome, and real-world clinical data to derive insights into disease progression, treatment response, and patient stratification.
Maintain awareness of current research trends in machine learning for biomedicine and contribute to scientific leadership in this space.
Publish research in top-tier ML and computational biology conferences and journals.
Who you are
Educational Background: Ph.D. in Computer Science, Machine Learning, Statistics, Mathematics, Physics, or a related field.
Experience: Proven track record of developing and applying advanced ML models in a research or industry setting.
Technical Skills:
Proficiency in scientific programming languages such as Python as well as MLOps workflows (e.g., familiar with code version control, high-performance compute infrastructures, and machine learning experiment monitoring workflows)
Strong experience with ML frameworks such as PyTorch, JAX, or TensorFlow.
Solid foundation in probabilistic modeling, deep learning, and representation learning.
Soft Skills: Excellent communication, collaboration, and problem-solving skills.
Publications: Strong publication record in ML, bioinformatics, or computational biology venues (e.g., NeurIPS, ICML, ICLR, RECOMB, Bioinformatics).
Preferred
Prior experience developing foundation models for omics or EHR data, including pretraining or fine-tuning strategies.
Deep knowledge of representation learning, generative modeling (e.g., VAEs, diffusion models, masked transformers), and multi-modal learning.
Experience integrating biological priors (e.g., pathways, ontologies, knowledge graphs) into model design.
Passion for advancing healthcare through innovation in ML and computational biology.
This opportunity needs to be based at Genentech in South San Francisco, and relocation benefits are available.
The expected salary range for this position, based on the primary location of California, is $167,400 - 310,800. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
#ComputationCoE
#tech4lifeComputationalScience
#tech4lifeAI
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Auto-ApplyApplied/Senior Applied AI Scientist, Translational AI Lab (TRAIL)
South San Francisco, CA jobs
** A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche.
Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche's Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide.
**The Opportunity**
The Translational AI Lab (TRAIL) is a team within AI Biology & Translation (AIBT) focused on applying and adapting state-of-the-art AI methods to solve key challenges in disease biology, target discovery, and translational research. TRAIL works in close collaboration with BRAID (Biology Research AI Development) and therapeutic area partners to integrate models into real-world scientific workflows. We are seeking a Scientist/Senior Scientist with a strong foundation in computational, statistical, and data science, and a passion for translating technical advances into biological and clinical impact. You'll work across large, multimodal datasets and help evaluate, adapt, and deploy AI models to advance scientific questions in early discovery and translational contexts.
+ Apply and fine-tune foundation models-such as large language models (LLMs), generative models, and multimodal encoders-for biological annotation, knowledge extraction, and biomarker hypothesis generation.
+ Design workflows and pipelines that integrate model outputs with real-world biological data (e.g., gene expression, perturbation screens, clinical biomarkers).
+ Evaluate model performance, robustness, and interpretability in collaboration with BRAID and therapeutic scientists.
+ Build tools and interfaces (e.g., notebooks, dashboards, chat-based validation flows) that connect AI capabilities with experimental and translational use cases.
+ Contribute to internal benchmarking, testing, and validation frameworks that enable scientific and strategic decision-making.
+ Collaborate across diverse teams of biologists, modelers, and software engineers to translate AI capabilities into program-level insights.
**Who You Are for the Scientist level**
+ Ph.D. or M.S. (with relevant experience) in Machine Learning, Computer Science, Data Science, Computational Biology, or a related quantitative field.
+ 0-3 years of relevant experience in AI, machine learning, or computational biology.
+ Strong technical foundation in deep learning and probabilistic modeling, with demonstrated project or publication experience.
+ Experience building and deploying ML/AI pipelines using Python, PyTorch, HuggingFace, and/or JAX; familiarity with tools like LangChain, Streamlit, or MLFlow is a plus.
+ Able to adapt and apply existing AI models (e.g., LLMs, encoders, transformers) in a rigorous, reproducible way to new biological domains.
+ Comfort working with biological or clinical data types-or strong interest in learning and collaborating closely with domain experts.
+ Excellent communicator who can collaborate in multi-disciplinary settings and explain technical results to scientific partners.
**Who You Are for the Senior Scientist level**
+ Ph.D. or M.S. (with relevant experience) in Machine Learning, Computer Science, Data Science, Computational Biology, or a related quantitative field.
+ 3-6 years of relevant experience in AI, machine learning, or computational biology.
+ Strong technical foundation in deep learning and probabilistic modeling, with demonstrated project or publication experience.
+ Experience building and deploying ML/AI pipelines using Python, PyTorch, HuggingFace, and/or JAX; familiarity with tools like LangChain, Streamlit, or MLFlow is a plus.
+ Able to adapt and apply existing AI models (e.g., LLMs, encoders, transformers) in a rigorous, reproducible way to new biological domains.
+ Comfort working with biological or clinical data types-or strong interest in learning and collaborating closely with domain experts.
+ Excellent communicator who can collaborate in multi-disciplinary settings and explain technical results to scientific partners.
**Preferred Experience for both**
+ Exposure to biomedical or multiomic data (e.g., single-cell, bulk RNA-seq, CRISPR screens, protein interaction networks).
+ Hands-on experience with LLM-based workflows, prompt engineering, fine-tuning, or real-time retrieval and evaluation systems (e.g., RAG, AutoGen).
+ Experience with benchmarking, evaluation frameworks, or model interpretability in applied settings.
+ Prior involvement in translational research, target discovery, or biomarker identification is a plus but not required.
**About AIBT and TRAIL**
AI Biology & Translation (AIBT) is a department within the Computational Sciences Center of Excellence (CS-CoE). AIBT connects foundational AI development (via BRAID) with translation and application (via TRAIL) to accelerate scientific impact across Genentech's R&D. TRAIL focuses on adapting and applying AI models to answer real biological questions, enable scientific decision-making, and shape how foundational models are built and deployed in context. It's where innovation meets application-through collaboration, iteration, and impact
Relocation benefits are available for this job posting.
The expected salary range for the Applied Scientist position based on the primary location of California is $127,500 - 236,700, and the expected salary for the Senior Applied Scientist based on the primary location of California is $147,800 - 274,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits (****************************************************
\#ComputationCoE
\#tech4lifeComputationalScience
\#tech4lifeAI
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .
Applied/Senior Applied AI Scientist, Translational AI Lab (TRAIL)
South San Francisco, CA jobs
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche.
Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche's Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The new Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness the transformative power of data and Artificial Intelligence (AI) to assist our scientists in both pRED and gRED to deliver more innovative and transformative medicines for patients worldwide.
The Opportunity
The Translational AI Lab (TRAIL) is a team within AI Biology & Translation (AIBT) focused on applying and adapting state-of-the-art AI methods to solve key challenges in disease biology, target discovery, and translational research. TRAIL works in close collaboration with BRAID (Biology Research AI Development) and therapeutic area partners to integrate models into real-world scientific workflows. We are seeking a Scientist/Senior Scientist with a strong foundation in computational, statistical, and data science, and a passion for translating technical advances into biological and clinical impact. You'll work across large, multimodal datasets and help evaluate, adapt, and deploy AI models to advance scientific questions in early discovery and translational contexts.
* Apply and fine-tune foundation models-such as large language models (LLMs), generative models, and multimodal encoders-for biological annotation, knowledge extraction, and biomarker hypothesis generation.
* Design workflows and pipelines that integrate model outputs with real-world biological data (e.g., gene expression, perturbation screens, clinical biomarkers).
* Evaluate model performance, robustness, and interpretability in collaboration with BRAID and therapeutic scientists.
* Build tools and interfaces (e.g., notebooks, dashboards, chat-based validation flows) that connect AI capabilities with experimental and translational use cases.
* Contribute to internal benchmarking, testing, and validation frameworks that enable scientific and strategic decision-making.
* Collaborate across diverse teams of biologists, modelers, and software engineers to translate AI capabilities into program-level insights.
Who You Are for the Scientist level
* Ph.D. or M.S. (with relevant experience) in Machine Learning, Computer Science, Data Science, Computational Biology, or a related quantitative field.
* 0-3 years of relevant experience in AI, machine learning, or computational biology.
* Strong technical foundation in deep learning and probabilistic modeling, with demonstrated project or publication experience.
* Experience building and deploying ML/AI pipelines using Python, PyTorch, HuggingFace, and/or JAX; familiarity with tools like LangChain, Streamlit, or MLFlow is a plus.
* Able to adapt and apply existing AI models (e.g., LLMs, encoders, transformers) in a rigorous, reproducible way to new biological domains.
* Comfort working with biological or clinical data types-or strong interest in learning and collaborating closely with domain experts.
* Excellent communicator who can collaborate in multi-disciplinary settings and explain technical results to scientific partners.
Who You Are for the Senior Scientist level
* Ph.D. or M.S. (with relevant experience) in Machine Learning, Computer Science, Data Science, Computational Biology, or a related quantitative field.
* 3-6 years of relevant experience in AI, machine learning, or computational biology.
* Strong technical foundation in deep learning and probabilistic modeling, with demonstrated project or publication experience.
* Experience building and deploying ML/AI pipelines using Python, PyTorch, HuggingFace, and/or JAX; familiarity with tools like LangChain, Streamlit, or MLFlow is a plus.
* Able to adapt and apply existing AI models (e.g., LLMs, encoders, transformers) in a rigorous, reproducible way to new biological domains.
* Comfort working with biological or clinical data types-or strong interest in learning and collaborating closely with domain experts.
* Excellent communicator who can collaborate in multi-disciplinary settings and explain technical results to scientific partners.
Preferred Experience for both
* Exposure to biomedical or multiomic data (e.g., single-cell, bulk RNA-seq, CRISPR screens, protein interaction networks).
* Hands-on experience with LLM-based workflows, prompt engineering, fine-tuning, or real-time retrieval and evaluation systems (e.g., RAG, AutoGen).
* Experience with benchmarking, evaluation frameworks, or model interpretability in applied settings.
* Prior involvement in translational research, target discovery, or biomarker identification is a plus but not required.
About AIBT and TRAIL
AI Biology & Translation (AIBT) is a department within the Computational Sciences Center of Excellence (CS-CoE). AIBT connects foundational AI development (via BRAID) with translation and application (via TRAIL) to accelerate scientific impact across Genentech's R&D. TRAIL focuses on adapting and applying AI models to answer real biological questions, enable scientific decision-making, and shape how foundational models are built and deployed in context. It's where innovation meets application-through collaboration, iteration, and impact
Relocation benefits are available for this job posting.
The expected salary range for the Applied Scientist position based on the primary location of California is $127,500 - 236,700, and the expected salary for the Senior Applied Scientist based on the primary location of California is $147,800 - 274,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
#ComputationCoE
#tech4lifeComputationalScience
#tech4lifeAI
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Principal Scientist I
Pleasanton, CA jobs
A healthier future. It's what drives us to innovate. At Roche, we are passionate about transforming patients' lives and are bold in both decision and action. We believe that good business means a better world. That is why we come to work each day, committed to scientific rigor, unassailable ethics, and ensuring access to medical innovations for all. We do this today to build a better tomorrow.
The Opportunity
We are seeking a highly motivated and innovative Principal Scientist to join our Molecular Diagnostics R&D team in Pleasanton, CA. This is a hands-on, lab-based role where you will serve as a subject matter expert in PCR technology, driving the development of next-generation molecular diagnostic assays.
Your mission will be to lead the design, optimization, and validation of novel PCR-based assays for our diagnostic platforms. You will translate complex scientific concepts into robust and reliable products that have a direct impact on patient care. This is an opportunity for a visionary scientist to not only pioneer new workflows but to help shape the future of molecular diagnostics at Roche.
Your Role and Responsibilities
As a Principal Scientist, you will lead from the bench and be a key technical leader and contributor within a dynamic, cross-functional team. Your responsibilities will include:
* Assay Development: Lead the design and development of PCR and/or digital PCR (dPCR) assays for molecular diagnostic applications. This includes primer/probe design, reaction buffer optimization, and protocol establishment.
* Optimization & Troubleshooting: Independently design and execute rigorous experiments (including DOE, or Design of Experiments) to optimize assay performance, robustness, and cost-effectiveness. Act as the primary technical expert for troubleshooting complex assay and instrument-related issues.
* Product Development: Drive R&D activities within a regulated product development framework (e.g., Design Control). Contribute to all phases of product development, from feasibility and proof-of-concept to verification, validation, and transfer to manufacturing.
* Data Analysis: Perform in-depth statistical analysis and interpretation of complex experimental data. You will be responsible for drawing sound scientific conclusions and making data-driven recommendations.
* Communication & Collaboration: Clearly and effectively communicate findings, progress, and strategic recommendations to project teams, R&D leadership, and non-technical stakeholders. Author technical reports, validation documents, and SOPs.
* Mentorship: Provide technical guidance and mentorship to junior scientists, fostering a culture of scientific rigor, innovation, and collaboration.
Who You Are
You are a self-motivated, hands-on scientist who thrives in a fast-paced, collaborative environment. You approach complex problems with a sense of urgency, optimism, and deep scientific curiosity.
Required Qualifications:
* A degree in Molecular Biology, Biochemistry, Genetics, or a related scientific field with the following experience:
* Bachelor's with at least 10 years of relevant industry experience.
* Master's with at least 7 years of relevant industry experience.
* PhD with at least 3-5 years of relevant industry experience.
* Profound understanding of PCR technology (qPCR, RT-qPCR) and its application in molecular diagnostics.
* Demonstrated hands-on experience in PCR assay design, optimization, and validation.
* Proven experience working within a molecular diagnostic product development environment.
* Strong data analysis skills using statistical software (e.g., JMP, R) and proficiency in data interpretation.
* Excellent interpersonal, presentation, and communication skills, with a proven ability to collaborate effectively across multidisciplinary teams.
Preferred Qualifications:
* Hands-on experience with digital PCR (dPCR) platforms and a strong understanding of dPCR applications in molecular diagnostics (e.g., oncology, infectious disease).
* Experience working under a regulated environment (e.g., IVD, FDA, CE-IVD) and familiarity with Design Control principles.
* Experience of working as a technical project lead and interfacing with a multifunction team.
* A track record of innovation as demonstrated by publications, patents, or successful product launches.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Senior Scientist 1, Biophysical Characterization
San Rafael, CA jobs
Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities.
Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options.
About Worldwide Research and Development
From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.
We are seeking a Senior Scientist 1 - Biophysical Characterization & Bioconjugation to lead analytical strategy and experimental design for therapeutic proteins and their bioconjugates-particularly enzyme- and antibody-based platforms. You will join the Biologics Therapeutic Modality Team, developing advanced biophysical workflows, designing custom assays to define structure-function relationships, and guiding conjugation strategies for next-generation molecules. Your contributions will directly influence lead candidate selection, manufacturability, and regulatory readiness, helping advance promising therapies from bench to clinic.
Key Responsibilities
* Strategic Leadership in Biophysical Characterization
* Lead biophysical characterization strategies for protein-based therapeutics (enzymes, antibodies, fusion proteins) and, as appropriate, other modalities such as nanoparticles and/or small molecules.
* Apply bioconjugation chemistry expertise to optimize critical product attributes such as half-life, specificity, and developability.
* Assay Development & Innovation
* Develop, optimize, and validate fit-for-purpose and high-throughput assays to assess higher-order structure, aggregation, stability, and binding interactions.
* For bioconjugates, evaluate conjugation efficiency, site occupancy, DAR/DPR, linker/payload stability, degradation profiles, and serum/matrix stability.
* Deliver well-documented, phase-appropriate analytical packages suitable for internal or CRO execution (development → qualification → transfer).
* Cross-Functional Collaboration
* Partner with Discovery, Therapeutic Development, Analytical Sciences, Protein Engineering, Formulation, and Regulatory teams to integrate biophysical insights and support decision-making at key development milestones.
* Technology Transfer & External Partnerships
* Lead technology transfer of assays and workflows to Analytical Sciences or external partners (CROs/CDMOs), ensuring SOP completeness, acceptance criteria, comparability plans, and data integrity standards.
* Scientific Innovation & External Engagement
* Stay current on bioconjugation and analytical biophysics innovations (e.g., mass photometry, HDX-MS, native/denaturing MS for DAR and site occupancy, FcRn assays).
* Evaluate and implement emerging platforms to strengthen data quality and reduce program risk.
* Regulatory Support
* Prepare analytical reports and datasets supporting IND/CTA submissions.
* Contribute to comparability assessments and respond to health authority queries in collaboration with CMC and Quality.
* Mentorship & Culture Building
* Act as a player-coach, mentoring junior scientists, maintaining high data integrity standards, and promoting a culture of excellence, innovation, and accountability.
Qualifications
* Education:
* Ph.D. in Biophysics, Biochemistry, Pharmaceutical Sciences, or Chemical/Biomedical Engineering preferred.
* M.S. or B.S. with significant industry experience will be considered.
* Experience:
* Ph.D. with 6+ years, M.S. with 10+ years, or B.S. with 12+ years of relevant experience in biophysical and analytical characterization of biologics.
* Proven success with therapeutic protein conjugates (enzymes, antibodies, fusion proteins). Experience with small-molecule or nanoparticle conjugates is an advantage.
* Technical Expertise:
* Working knowledge or hands-on experience in at least one or two methods per category:
* Size/Assembly: SEC-MALS, FFF-MALS, AUC, DLS, Mass Photometry
* Structure/Stability: DSC, DSF, CD, FTIR, HDX-MS (preferred)
* Binding/Mechanism: SPR, BLI, ITC, MST
* Chromatography/Charge/Identity: HIC, IEX, RP-HPLC, CE-SDS, cIEF, LC-MS (intact mass, peptide mapping; native/denaturing for DAR/site occupancy)
* Conjugation Analytics: DAR/DPR analysis, linker/payload stability, forced degradation, serum/matrix stability
* Regulatory & CMC:
* Experience contributing to IND/CTA filings and supporting method lifecycle management for complex biologics and conjugates.
Core Competencies
* Strong experimental design, quantitative analysis, and problem-solving skills
* Clear written and verbal communication
* Ability to lead and collaborate within cross-functional, matrixed teams
* Experience managing CRO/CDMO deliverables
Preferred Qualifications
* Experience establishing release and stability testing panels for biologics or conjugates
* Demonstrated success transferring analytical methods to/from CROs/CDMOs, including full documentation and comparability packages
* Familiarity with regulatory submissions and agency interactions for bioconjugates or ADCs
* Evidence of scientific innovation, such as peer-reviewed publications, patents, or conference presentations
Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned.
Equal Opportunity Employer/Veterans/Disabled
An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
The salary range for this position is: $128,000 to $176,000. BioMarin considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans.
For additional benefits information, visit:
Scientist 3, Single Cell Genomics and Epigenetics
South San Francisco, CA jobs
** A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.
The Department of Cell and Tissue Genomics is seeking a creative, rigorous, and motivated Scientist 3 to develop and apply cutting-edge single cell genomic and epigenetic techniques to study cancer biology. The successful candidate will deploy these technologies to interrogate molecular mechanisms underlying disease states and identify candidate targets for therapeutic interventions. They will work in collaboration with colleagues in the departments of Research Oncology, Translational Medicine, and/or Computational Sciences. This is a hands-on position with both experimental and computational analysis components.
**The Opportunity**
+ Develop and apply multimodal single-cell and epigenetic technologies in cell lines, disease models, and primary tissue samples
+ Analyze and interpret single-cell genomics and epigenetic sequencing data
+ Effectively collaborate with teams within the department and across Genentech
+ Communicate results through scientific publications and presentations
+ Contribute to identifying new research opportunities
**Who You Are**
+ Doctorate degree in a relevant field, including molecular biology, cancer biology, genetics, immunology, systems biology, developmental biology, biochemistry, and/or biomedical engineering. Minimum of 4 years total academic and/or industry experience
+ Strong background in NGS assays, including epigenetic assays.
+ Experience with genomic/epigenomic data analyses and interpretation (R and/or Python)
+ Excellent oral and written presentation skills
+ Ability to manage multiple projects in parallel, collaborate with multidisciplinary teams, and lead research projects
+ Sustained record of productivity in the form of publications and patents.
**Preferred**
+ Single cell genomic assay experience preferred.
+ Genomic technology development or optimization experience preferred
+ Experience with CRISPR genome editing and high throughput screens is a plus
+ Cancer biology or immunology expertise is a plus
Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
**Benefits (******************************************************
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (***************************************************************************************************** .
Scientist 3, Single Cell Genomics and Epigenetics
South San Francisco, CA jobs
A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.
The Department of Cell and Tissue Genomics is seeking a creative, rigorous, and motivated Scientist 3 to develop and apply cutting-edge single cell genomic and epigenetic techniques to study cancer biology. The successful candidate will deploy these technologies to interrogate molecular mechanisms underlying disease states and identify candidate targets for therapeutic interventions. They will work in collaboration with colleagues in the departments of Research Oncology, Translational Medicine, and/or Computational Sciences. This is a hands-on position with both experimental and computational analysis components.
The Opportunity
* Develop and apply multimodal single-cell and epigenetic technologies in cell lines, disease models, and primary tissue samples
* Analyze and interpret single-cell genomics and epigenetic sequencing data
* Effectively collaborate with teams within the department and across Genentech
* Communicate results through scientific publications and presentations
* Contribute to identifying new research opportunities
Who You Are
* Doctorate degree in a relevant field, including molecular biology, cancer biology, genetics, immunology, systems biology, developmental biology, biochemistry, and/or biomedical engineering. Minimum of 4 years total academic and/or industry experience
* Strong background in NGS assays, including epigenetic assays.
* Experience with genomic/epigenomic data analyses and interpretation (R and/or Python)
* Excellent oral and written presentation skills
* Ability to manage multiple projects in parallel, collaborate with multidisciplinary teams, and lead research projects
* Sustained record of productivity in the form of publications and patents.
Preferred
* Single cell genomic assay experience preferred.
* Genomic technology development or optimization experience preferred
* Experience with CRISPR genome editing and high throughput screens is a plus
* Cancer biology or immunology expertise is a plus
Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $101,400 - $188,200. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Senior Scientist 1, Biophysical Characterization
San Rafael, CA jobs
Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities.
Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best - people with the right technical expertise and a relentless drive to solve real problems - and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we've produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options.
About Worldwide Research and Development
From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.
We are seeking a Senior Scientist 1 - Biophysical Characterization & Bioconjugation to lead analytical strategy and experimental design for therapeutic proteins and their bioconjugates-particularly enzyme- and antibody-based platforms. You will join the Biologics Therapeutic Modality Team, developing advanced biophysical workflows, designing custom assays to define structure-function relationships, and guiding conjugation strategies for next-generation molecules. Your contributions will directly influence lead candidate selection, manufacturability, and regulatory readiness, helping advance promising therapies from bench to clinic.
Key Responsibilities
Strategic Leadership in Biophysical Characterization
Lead biophysical characterization strategies for protein-based therapeutics (enzymes, antibodies, fusion proteins) and, as appropriate, other modalities such as nanoparticles and/or small molecules.
Apply bioconjugation chemistry expertise to optimize critical product attributes such as half-life, specificity, and developability.
Assay Development & Innovation
Develop, optimize, and validate fit-for-purpose and high-throughput assays to assess higher-order structure, aggregation, stability, and binding interactions.
For bioconjugates, evaluate conjugation efficiency, site occupancy, DAR/DPR, linker/payload stability, degradation profiles, and serum/matrix stability.
Deliver well-documented, phase-appropriate analytical packages suitable for internal or CRO execution (development → qualification → transfer).
Cross-Functional Collaboration
Partner with Discovery, Therapeutic Development, Analytical Sciences, Protein Engineering, Formulation, and Regulatory teams to integrate biophysical insights and support decision-making at key development milestones.
Technology Transfer & External Partnerships
Lead technology transfer of assays and workflows to Analytical Sciences or external partners (CROs/CDMOs), ensuring SOP completeness, acceptance criteria, comparability plans, and data integrity standards.
Scientific Innovation & External Engagement
Stay current on bioconjugation and analytical biophysics innovations (e.g., mass photometry, HDX-MS, native/denaturing MS for DAR and site occupancy, FcRn assays).
Evaluate and implement emerging platforms to strengthen data quality and reduce program risk.
Regulatory Support
Prepare analytical reports and datasets supporting IND/CTA submissions.
Contribute to comparability assessments and respond to health authority queries in collaboration with CMC and Quality.
Mentorship & Culture Building
Act as a player-coach, mentoring junior scientists, maintaining high data integrity standards, and promoting a culture of excellence, innovation, and accountability.
Qualifications
Education:
Ph.D. in Biophysics, Biochemistry, Pharmaceutical Sciences, or Chemical/Biomedical Engineering preferred.
M.S. or B.S. with significant industry experience will be considered.
Experience:
Ph.D. with 6+ years, M.S. with 10+ years, or B.S. with 12+ years of relevant experience in biophysical and analytical characterization of biologics.
Proven success with therapeutic protein conjugates (enzymes, antibodies, fusion proteins). Experience with small-molecule or nanoparticle conjugates is an advantage.
Technical Expertise:
Working knowledge or hands-on experience in at least one or two methods per category:
Size/Assembly: SEC-MALS, FFF-MALS, AUC, DLS, Mass Photometry
Structure/Stability: DSC, DSF, CD, FTIR, HDX-MS (preferred)
Binding/Mechanism: SPR, BLI, ITC, MST
Chromatography/Charge/Identity: HIC, IEX, RP-HPLC, CE-SDS, cIEF, LC-MS (intact mass, peptide mapping; native/denaturing for DAR/site occupancy)
Conjugation Analytics: DAR/DPR analysis, linker/payload stability, forced degradation, serum/matrix stability
Regulatory & CMC:
Experience contributing to IND/CTA filings and supporting method lifecycle management for complex biologics and conjugates.
Core Competencies
Strong experimental design, quantitative analysis, and problem-solving skills
Clear written and verbal communication
Ability to lead and collaborate within cross-functional, matrixed teams
Experience managing CRO/CDMO deliverables
Preferred Qualifications
Experience establishing release and stability testing panels for biologics or conjugates
Demonstrated success transferring analytical methods to/from CROs/CDMOs, including full documentation and comparability packages
Familiarity with regulatory submissions and agency interactions for bioconjugates or ADCs
Evidence of scientific innovation, such as peer-reviewed publications, patents, or conference presentations
Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned.
Equal Opportunity Employer/Veterans/Disabled
An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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