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Founding ImClone in 1984
As the situation at Mount Sinai soured for Waksal, he took a leave of absence in 1984 to establish ImClone, an endeavor to which he would devote all his energy after exiting Mount Sinai.
1984: The company is incorporated.
The Wall Street Journal interviewed Alexandra Bona who worked for Waksal: "'One day in 1985, the Waksal lab imploded,' she recalls.
In 1986 ImClone opened its own laboratories, located in Manhattan's SoHo district on the site of a bankrupt shoe factory.
According to Business Week, "Over the next few years, Sam engineered several funding deals to keep ImClone alive until the company went through with its IPO in 1991.
Charles Berner of Yardley, Pa., has owned ImClone stock since its initial public offering in 1991. “If Sam didn’t do the thing that he did way back and it wasn’t tainted by the Martha Stewart thing,” Mr.
To move into clinical trials as soon as possible the Waksals bought a former New Jersey computer-chip factory and retrofitted it to produce the drug, which began to be tested on human patients in 1994, the same year that the biotech stocks suffered another crash.
That emphasis would shift in 1999 when Erbitux was used on a patient named Shannon Kellum, who had colon cancer that spread to her liver and abdomen.
The initial 125-patient study launched in 1999 was another gamble for the company, limited to patients who had already failed irinotecan treatment.
According to a 2002 New York Times profile, "Doctor Waksal has been sued several times for not paying his bills.
When the stock was at its nadir in 2002, Bristol-Myers could have picked up the rest of ImClone for a song.
Despite all the controversy surrounding the company, ImClone's fortunes, as well as the price of its stock, began to rebound in 2003, mostly on the strength of continuing efforts by Merck KgaA to gain approval for Erbitux in Europe.
Icahn took control of ImClone’s board of directors following a proxy fight in October 2006.
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| Company name | Founded date | Revenue | Employee size | Job openings |
|---|---|---|---|---|
| Regeneron | 1988 | $14.2B | 9,123 | 317 |
| Seagen | 1997 | $2.0B | 900 | - |
| United Therapeutics | 1996 | $2.9B | 950 | 216 |
| Sanofi Genzyme | 1981 | $4.6B | 12,000 | - |
| Exelixis | 1994 | $2.2B | 484 | 160 |
| Amgen | 1980 | $33.4B | 22,000 | 679 |
| Merck | 1891 | $64.2B | 74,000 | 2,283 |
| Editas Medicine | 2013 | $32.3M | 133 | 2 |
| MannKind | 1991 | $10.0M | 233 | 47 |
| CIMA Labs | 1986 | $8.5M | 120 | 18 |
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