Ionis Pharmaceuticals Jobs

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! MEDICAL DIRECTOR - DRUG SAFETY PHYSICIAN SUMMARY: The Medical Director, Drug Safety Physician, collaborates with the Product Lead or Head of Drug Safety and is responsible for the clinical safety strategy for assigned drug projects and products. They provide drug safety expertise and guidance to Clinical Development, the Safety Oversight Committee (SOC), and the Clinical Project Teams, while also leading the proactive implementation of risk management initiatives in accordance with global regulatory requirements. Major areas of responsibility include continuous efficient evaluation of safety data to perform signal detection and evaluation and predict and manage the safety profile of compounds in clinical development, consistent communication of safety topics across all regulatory safety documents, and strategic collaboration with cross-functional teams in support of the products and Ionis business partners. This position reports to the Safety Team Lead of assigned products. RESPONSIBILITIES: Performs individual case report assessment and determines regulatory reporting responsibilities as required Provides medical review of case narratives for medical content, accuracy, and signal detection Interpret aggregate safety data for periodic reports and evaluating for potential new signals Provides support and is capable of leading signal detection, signal evaluation, data analysis, and benefit-risk evaluation for assigned compounds, including ability to author signal report in response to Health Authority inquiries Provides support and can lead risk management and risk mitigation activities, including medical and safety leadership for RMPs Writes individual case assessments and evaluates aggregate safety data for periodic reports as required Provides medical input into identification and utilization of appropriate sources of information and database searches to retrieve relevant data for evaluation of signals Proactively evaluates the clinical implications of safety data from pre-clinical studies, clinical studies, literature, and other information sources in order to predict/establish the safety profile of compounds in clinical development Offers medical judgment on complex safety issues Works cross functionally with clinical to determine the most appropriate monitoring and stopping rules for clinical trial protocols in partnership with the project's medical monitor Supports and can present safety data to DSMBs for assigned products Collaborates with partner company's drug safety team and clinicians, and provisions regular safety summaries Contributes to/reviews the Safety Data Exchange Agreements and other documents shared with partners; provides vendor oversight for assigned products Participates in cross-functional project teams; communicates across organizational levels and functions Participates in SOP updates, audits, and inspection readiness Writes/updates core safety information for assigned projects Writes/reviews and provides technical input for the safety sections of regulatory documents for assigned projects (i.e., protocols, IBs, ICFs, CSRs, IND/MAA submissions, RMP, annual reports, etc.) Prepares and/or reviews safety documents (DSURs, PBRERs, 6MLL, etc) and provides strategic input into responses to regulatory inquiries Participates in external regulatory and non-regulatory meetings, including those with consultants and other companies, such as licensing partners May assist in due diligence activities May provide support to Legal for product liability litigation, as appropriate Supports the medical coding group on an ad hoc basis Participates in reconciliation procedures Guides and/or trains external personnel/parties involved in Ionis' clinical studies Collaborates effectively in cross-functional and cross-cultural project teams and environments, and work with external providers Maintain clinical and technical expertise in the therapeutic areas in which Ionis operates (i.e., through review of scientific journals, attendance at scientific and key technical meetings, etc.) May support and/or contribute to writing of white papers and other internal scientific publications Assist in accomplishing department and corporate objectives May participate/present safety material to Investigator's meetings and other medical meetings Participates in selection and bidding activities for vendors and contractors Managerial responsibilities as required Other duties and ad hoc activities as assigned REQUIREMENTS: Medical degree (e.g., MD, MBBS) At least 5 years of clinical experience post-registration High level of medical competence, with an ability to balance this with industry standards to achieve business goals At least 5 years of Drug Development/Patient Safety experience (the majority of which should be in industry in Patient Safety) with clear evidence of delivery A thorough knowledge of the pharmaceutical/biopharmaceutical industry, especially clinical research and global regulatory requirements, and practices governing expedited and periodic safety reporting, signal generation, safety evaluation, and risk management activities. Able to work across therapeutic areas and functions Works collaboratively (establishes shared purpose across boundaries) Develops people and the organization (invests in long-term development of others) Please visit our website, ******************** for more information about Ionis and to apply for this position; reference requisition # IONIS003777 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************ The pay scale for this position is $235,553 to $314,252 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Are you ready for a new beginning? We need your talent, knowledge and dedication to better our world with biology. Our purpose points the way In Novonesis, we know that solutions rooted in biology can help solve humanity's biggest challenges. Since we began more than a century ago, this has been our guide. It's how we've gotten so far. And it's how we'll impact the future. Now, more than ever, the world needs change. And with biosolutions, the possibilities for transformation are endless. We're here to better our world with biology. Join us as our new Research Assistant or Research Associate We are seeking a Research Assistant or Research Associate scientist to join our Strain Engineering Department within our R&D site located in Davis, California. The site of 60+ employees in Davis works together to unlock the potential of bacteria, yeast and filamentous fungi as biological solutions to address the needs in our world. We foster a collaborative environment with a shared vision for pursuing science that has an impact, by working smart and enjoying the scientific journey. In this role you'll make an impact by: * Working in cross-functional teams of researchers to design, build and test engineered microbes to support local and global projects * Developing and applying tools of strain design and engineering to a diverse collection of microorganisms, including bacteria, yeast, and filamentous fungi * Working in teams to unlock applications and biological insights you'd never achieve on your own To succeed you must hold: * B.S. in Molecular Biology, Biotechnology, Microbiology, Biochemistry or related field * Conceptual and practical knowledge molecular biology * Strong written and oral communication skills * A strong desire to work as a member of an empowered, cross-disciplinary problem-solving team * A mindset that embraces challenging science, recognizes change as an opportunity and finds satisfaction in team success Prior experience with one or more of the following is especially beneficial in this position: * Contributed to strain improvement programs focused on protein expression, metabolic engineering or other applied objectives * Experience developing and/or applying CRISPR tools for engineering of bacteria, yeast or filamentous fungi * Familiarity with Benchling or other similar electronic laboratory notebook system * Operating and programming liquid handling robots (Biomek, Hamilton, or Opentrons) * Python coding experience for scientific data analysis The salary range for this position is $55,000-$70,000/year. The position will be hired at a level commensurate with relevant experience. This role is an on-site position at our Davis, California facility. Application Deadline: 6/13/25 Could our purpose be yours? Then apply today! At Novonesis we commit to an inclusive recruitment process and equality of opportunity for all our job applicants. We recommend you not to attach a cover letter to your application. Instead, please include a few sentences in your resume/CV about why you are applying. To ensure a fair recruitment process, please refrain from adding a photo in your resume/CV. Novonesis is committed to creating a diverse environment and is proud to be an equal opportunity and affirmative action employer. All employment decisions are based on business needs without regard to race, color, ethnicity, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, disability, or veteran status. Want to learn more? Learn more about Novonesis, our purpose, and your career opportunities at novonesis.com Not the right fit for you? Even if this job isn't the right fit for you, perhaps you know someone who might find it interesting. If so, please feel free to share the job link and encourage them to apply. Thank you for your referral! Please check out our other open positions. The right fit for you could just be a few clicks away.

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! PAYROLL ANALYST II SUMMARY: We are seeking an individual with the knowledge and expertise to effectively support payroll activities for 1,000+ multi-state and global employees. This position requires working effectively and efficiently in an environment that demands high productivity while meeting multiple deadlines within very tight schedules. RESPONSIBILITIES: * Bi-weekly payroll processing for 1,000+ employees using UKG Pro and UKG Time Management * Review and process timesheets to ensure accurate payment of work hours and paid time off (vacation, holiday, sick and volunteer time) * Calculate manual checks, leave of absence pay and terminations * Process payroll related employee changes (FTE/FLSA change, name/address change, work authorization change, direct deposit change, garnishments, etc.) * Ensure payroll reports are reviewed and balanced timely * Reconcile and prepare 401(k) and HSA funding * Maintain bi-weekly 401(k) contribution spreadsheet * Monthly payroll processing for global employees using ADP/Celergo * Process stock transaction payrolls for nonqualified stock exercises and RSU releases * Conduct weekly New Hire Orientation * Maintain strict confidentiality with compensation related information * Create, research, and resolve UKG Pro support cases and service requests * Maintain related files and records in compliance with company and Sarbanes Oxley (SOX) requirements * Ensure compliance with federal, state, and other regulatory requirements * Generate reports, conduct specialized research projects, and respond to inquiries as required (benefit audits, workers' comp audits, etc.) * Other duties as assigned REQUIREMENTS: * Bachelor's degree in related field or equivalent experience * 3+ years in a payroll support position * Experience with UKG Pro and UKG Time Management preferred * Experience with Morgan Stanley (E*Trade) Equity Edge Online preferred * Experience with SAP Success Factors Payroll a plus * Intermediate/Advanced Microsoft Excel skills (vLookup and Pivot Table functions at a minimum) * Demonstrated knowledge of Federal and State Labor laws, pay practices and policies * Exceptional attention to detail * Strong people skills and a positive attitude * Outstanding organizational skills with the ability to multi-task and prioritize * Strong work ethic and an ability to be productive and successful in an intense work environment * Required to be onsite in Carlsbad, CA a minimum of three days per week Please visit our website, ******************** for more information about Ionis and to apply for this position; reference requisition # IONIS003615 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************ The pay scale for this position is $57,645 to $82,851 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Are you ready for a new beginning? We need your talent, knowledge and dedication to better our world with biology. Our purpose points the way In Novonesis, we know that solutions rooted in biology can help solve humanity's biggest challenges. Since we began more than a century ago, this has been our guide. It's how we've gotten so far. And it's how we'll impact the future. Now, more than ever, the world needs change. And with biosolutions, the possibilities for transformation are endless. We're here to better our world with biology. Global Strategic Account Manager The global strategic account manager has a sales responsibility for a specific strategic account (SA) for Human Health (HH) probiotic and synbiotic activities - Responsible for all projects and relationships linked to a specific SA - Creation and execution of Global Strategic Account Plans - Secure SA's and market input from Territory RSM and HH HQ - Responsible for sales budget, sales estimate, forecast and project management in Salesforce. In this role you'll make an impact by: * Meet and or exceed pre-defined sales targets and execute Global or Regional pricing strategies * Position company in the marketplace as a trustworthy, flexible, and knowledgeable probiotic partner * Manage and develop existing SA relationships and projects * Drive commercial agreement discussion with the support of RSD and Legal * Develop relationship network inside SA organization * Be the voice of the customer and the one responsible for managing the customers' expectations and goals in cross-functional development activities initiated by the customer * Responsible for organizing and handling customer meetings in a professional manner * Manage and continuously update complex SA sales plans and understand quality strategy * Execute the HH Regional and Global product line strategies * Manage SA projects through Salesforce or SA's request process * Provide procurement with timely forecasting * Update BI estimate system on a timely basis, provide timely monthly reports, etc. * Secure feedback from the market and customers on global product line, marketing activities, pricing, and value chain issues * Secure that market, industry and competitor information is captured, organized, and communicated to RSM and HH HQ * Participate in trade shows, global and regional sales meetings To succeed you must have: * 5+ years of sales experience preferably in dietary supplement/probiotic knowledge, and/or OTC market * Strategic Sales Account with large customers or Key Account experience * Project management experience * Territory language requirement (English) with preferred Spanish and/or Mandarin * Travel up to 30% based on client need Salary expected: $155,000-$175,000 base + bonus based on revenue. Salary based on location and years of industry experience * Location: Fully remote * Application deadline: June 20, 2025 * Benefits you will enjoy: * 401(k) with up to a 9% company contribution! * Minimum of 3 weeks' vacation plus 12 holidays and 2 weeks of Wellness Time * Health, Dental, Vision & Life insurance * Healthcare savings account option with generous employer contribution * Employee assistance program * Parental leave * Tuition reimbursement * All benefits begin on your first day! #LI-Remote Could our purpose be yours? Then apply today! At Novonesis we commit to an inclusive recruitment process and equality of opportunity for all our job applicants. We recommend you not to attach a cover letter to your application. Instead, please include a few sentences in your resume/CV about why you are applying. To ensure a fair recruitment process, please refrain from adding a photo in your resume/CV. Novonesis is committed to creating a diverse environment and is proud to be an equal opportunity and affirmative action employer. All employment decisions are based on business needs without regard to race, color, ethnicity, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, disability, or veteran status. Want to learn more? Learn more about Novonesis, our purpose, and your career opportunities at novonesis.com Not the right fit for you? Even if this job isn't the right fit for you, perhaps you know someone who might find it interesting. If so, please feel free to share the job link and encourage them to apply. Thank you for your referral! Please check out our other open positions. The right fit for you could just be a few clicks away.

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! IT Operations Analyst III Position Overview: Ionis Pharmaceuticals is seeking a highly skilled and experienced IT Operations Analyst III to join our dynamic IT team. The successful candidate will play a pivotal role in optimizing and managing IT operations to ensure maximum efficiency, reliability, and security across the organization. This position involves providing advanced Level 2 and Level 3 support for line-of-business applications, including Office 365 administration, Okta, Entra, SharePoint, Veeva, and Cayosoft account creation. Responsibilities also include diagnosing and resolving complex technical issues, monitoring system performance, supporting high-profile meetings such as inspections, audits, and data readouts, and implementing strategic improvements to enhance our IT infrastructure and end-user support. The IT Operations Analyst III will collaborate closely with cross-functional teams to evaluate IT requirements and deliver tailored technical support to meet business needs. Key responsibilities include developing knowledge base articles, creating and maintaining L0 self-help video documentation for our user base, and conducting regular analysis of problem trends to identify solutions or process improvements. Staying abreast of emerging industry trends and technologies, such as security behavior and culture programs and generative AI to automate and optimize IT operations, is crucial for driving innovation and maintaining a competitive edge while maximizing resource output. The ideal candidate will possess a proven track record in IT operations, particularly within the biotech and life sciences sector, demonstrating a deep understanding of industry-specific IT challenges and regulatory requirements. They should have a history of successfully managing IT infrastructure, optimizing service delivery, and implementing strategic process improvements that enhance overall efficiency. The candidate must excel in diagnosing and resolving technical issues, proactively identifying areas for improvement, and driving technological innovation within a complex and fast-paced environment. Strong leadership, collaboration, and communication skills are essential, as well as the ability to adapt to evolving business needs while ensuring consistent, high-quality IT support and service. The IT Operations Analyst III is responsible for delivering advanced Level 2 and Level 3 support to internal customers, addressing complex issues related to computer hardware, software, and networked systems. This role involves proactively identifying, managing, and resolving events, incidents, and problems to minimize business disruptions and ensure the rapid restoration of normal service operations. Key responsibilities include managing technical service activities and coordinating with both internal teams and outsourced service providers to deliver high-quality technical solutions and support. The Analyst will deliver technical support for a range of platforms and applications, including Windows 10, Windows 11, mac OS, iOS, Office 365, Okta Administration, Zoom Administration, SharePoint, SAP, Veeva, Adobe Sign, Adobe Acrobat, Azure AD, Copilot, Intune, and scientific tools such as GraphPad Prism, ChemStation, ChemDraw, JMP, Mimecast Administration, and Microsoft Teams. This is an on-site position, Monday through Friday, with some after-hours support required, maintaining a physical presence in the office in which candidate is hired (Carlsbad, Boston, Dublin). Onsite support includes hardware and software support, white glove C-suite support, and conference room technical support. Additionally, the IT Operations Analyst III will use remote tools such as TeamViewer Quick Support to assist and support the remote user base across the United States and Europe. The Analyst will utilize ticketing systems such as SolarWinds Service Desk to manage and resolve issues, demonstrate proficiency with Microsoft Teams, manage IT inventory and assets effectively, conduct end-user training including new hire orientation, maintain the service desk knowledge base, and be proficient in process documentation. Experience with Cayosoft Administrator Console, on-prem Active Directory, Exchange Online administration, and mobile phone support (e.g., Verizon admin console, Apple Business Manager) is also required. Vendor and MSP Management: • Serve as the primary point of contact for Managed Service Providers (MSPs) and third-party vendors supporting IT operations. • Establish and maintain strong relationships with vendors to ensure high-quality service delivery and adherence to SLAs. • Evaluate vendor performance, review contracts, and recommend renewals or replacements as necessary. • Collaborate with procurement teams to manage IT-related vendor contracts, budget forecasting, and service agreements. • Work with external partners to optimize support processes, implement improvements, and ensure seamless integration with internal IT functions. Team Collaboration: The IT Operations Analyst III will work closely with various teams across the organization to ensure seamless IT operations. * Cross-Functional Collaboration: Partnering with departments such as R&D, HR, and Finance to understand their IT needs and provide tailored support. * Project Teams: Participating in IT projects, contributing technical expertise, and ensuring project goals are met on time. * Vendor Coordination: Managing relationships with external service providers to ensure high-quality service delivery and support. * Knowledge Sharing: Collaborating with team members to share knowledge, best practices, and provide mentorship to junior staff. * Regular Meetings: Attending and contributing to regular team meetings to discuss ongoing issues, upcoming projects, and continuous improvement initiatives. Experience: * A bachelor's degree in information technology, computer science or equivalent field preferred * A minimum of 5 years of experience in the IT industry required, 3+ years of experience with master's degree * Proven experience in IT operations, particularly in service desk support, incident management, and vendor management. Requirements: * Exceptional customer service skills to facilitate effective communication with internal stakeholders. * Strong problem-solving capabilities to efficiently prioritize and resolve technical issues. * Proficiency in Office 365 administration, including expertise in user and license management. * Hands-on experience with identity and access management tools, such as Okta and Microsoft Entra. * In-depth knowledge of SharePoint administration, including maintenance and troubleshooting. * Familiarity with tools like Veeva and Cayosoft for account creation and management. * Comprehensive understanding of network connectivity principles and troubleshooting techniques. * Proven ability to diagnose and resolve application errors and performance-related issues. * Demonstrated project management skills, considered highly advantageous. * Experience in administering ticketing and incident management tools, such as SolarWinds Service Desk. * Demonstrated adaptability, with a strong drive to explore and implement technology-based solutions. * Exceptional verbal and written communication skills, enabling effective interaction with stakeholders at all levels of the organization. * Proven ability to work collaboratively as a strong team player, fostering a positive and productive team environment where ideas and concepts are constructively challenged to achieve the best outcomes. Please visit our website, ******************** for more information about Ionis and to apply for this position; reference requisition #IONIS003549 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************ The pay scale for this position is $84,012 - $112,976 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. #LI-Onsite - Carlsbad, CA or Boston, MA, or Dublin, Ireland

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! POSTDOCTORAL RESEARCHER - CARDIOVASCULAR GENE EDITING/ DELIVERY SUMMARY: We are seeking an enthusiastic postdoctoral scientist interested in using CRISPR gene editing to address root causes of heart failure and arrhythmia to join the Cardiovascular Drug Discovery group, a multi-disciplinary team of energetic researchers. The successful candidate will work in a matrix group environment to explore in vivo gene editing for cardiovascular diseases. He/She will work independently to conceptualize, design and execute experiments using rodent and human cell models. Background in RNA, molecular biology, and CRISPR/Cas systems are essential for the position. Experience in cardiovascular biology and drug delivery is a plus. RESPONSIBILITIES: * Design, execute and troubleshoot experiments relevant to the postdoctoral project * Formulate solutions for delivery of therapeutics in vitro and in vivo and contribute to optimization. * Measure and analyze pharmacodynamic and functional effects of treatments in rodent and cell models of disease. * Present results at internal and external scientific meetings. * Prepare manuscript for publication. REQUIREMENTS: * Ph.D. in molecular biology, biochemistry, or related fields with 0-3 years of postgraduate training. * Strong laboratory skills in molecular biology and biochemical assays, e.g. RNA and protein isolation, RT-qPCR, ELISA, Western Blotting. * Proficiency in rodent handling, dosing (IV, SC, IM) and necropsy. * Hands-on experience with CRISPR/Cas systems. * Excellent written and verbal communication skills. * Required to be full-time onsite at Carlsbad, CA. PREFERRED SKILLS: * Experience with in vivo imaging systems (IVIS) is desirable. * Exposure to non-viral vector in vivo delivery desirable. * Experience with lipid formulation for in vivo and in vitro delivery. * Experience with cardiomyocyte culture (primary and/or iPSC-CMs). * Exposure to cardiac functional assessments, including echocardiography. * Experience with confocal microscopy. Please visit our website, ********************* for more information about Ionis and to apply for this position; reference requisition #IONIS003471 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************* The pay scale for this position is $78,000 to $87,000 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. #LI-Onsite

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! TOXICOLOGY STUDY COORDINATOR SUMMARY: We are seeking a highly organized and detail-oriented professional to join our Toxicology team as a Study Coordinator. In this cross-functional role, you will serve as the primary liaison between Ionis, our contract research organizations (CROs), and various internal teams. At Ionis, we are committed to fostering a diverse and inclusive workplace where all individuals are valued, respected, and empowered to contribute their unique perspectives. RESPONSIBILITIES: The Study Coordinator role is a fast-paced, cross-functional, vital role in the smooth execution of Ionis nonclinical study conduct. Study Coordination and Operational Responsibilities include: * Facilitation of study contracts (SOWs) * Test article and formulation requests, review of study protocols, reports, amendments, etc. * Track and maintain study specific milestones using in-house database in support of quarterly finance updates * Coordinate sample shipments, receipt and transfer of sensitive study samples; maintain Chain of Custody * Prepare, review and distribute shipping/data templates (strong excel proficiency required) * Maintain and update study outlines templates * General assistance to Ionis Scientists will be an essential part of the role and additional non study specific support may be required across departments * QC various reports, data, data tables, presentations, documents for regulatory submissions (eg IND, IB) using advanced functions of MS Word, Excel and e-sub compliance software, as appropriate. * Plan, prioritize, and manage a diverse workload with associated responsibilities * Schedule and participate in department and study-related meetings, as required. Also, prepare meeting minutes. * General operational support including document processing (e.g., ELN, study tracker management, etc.), maintaining file systems for accuracy and completeness, invoice review and approval REQUIREMENTS: * A Bachelor's degree in biology or a related science field is required along with a minimum of 5 years relevant experience. Experience in animal sciences is strongly encouraged. * Strong candidates must be highly proficient with Microsoft Office applications * Possess excellent organizational, multitasking, and communication skills * The ability to work both independently and collaboratively is essential * The ideal candidate will also demonstrate flexibility and adaptability in a dynamic, team-oriented environment * This position is 100% on-site Please visit our website, ******************** for more information about Ionis and to apply for this position; reference requisition # IONIS003716 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************ The pay scale for this position is $89,397 to $106,264 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! SENIOR MANAGER - HEALTH, SAFETY & ENVIRONMENT (HS&E) SUMMARY: We have an exciting opportunity in the Health, Safety & Environment group (HS&E) department. You will be working with a highly motivated and cross functional team to build a proactive safety culture and execute exciting initiatives. We are looking for a self-starter with superior analysis and problem-solving skills ranging from simple to complex situations. This individual is expected to explain information and influence others to secure successful implementation of HS&E programs and directives as assigned. RESPONSIBILITIES: The HS&E senior manager will work to ensure a strong safety culture, compliance and implement best practices as appropriate. Basic essential duties for Department staff include: Exercises judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions Works on problems of diverse scope in which analysis of data requires evaluation of identifiable factors Demonstrating competent negotiation skills when dealing with challenging situations Providing responsive customer service when needed in the form of technical support, training, program development and HS&E program implementation Uses company's policies and procedures to solve moderate range of difficult problems in imaginative and practical ways Demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought Solves difficult technical issues and works to build alignment around a complex situation Specific duties for this role are to work independently with minimal supervision to lead designated programs to ensure compliance, efficiency, and world class customer service. These designated program duties include: Serving as a primary point of contact for the Facilities group Participation in the site Emergency Response team including the ability to wear a respirator Ability to provide 24h HS&E support for emergency response as needed Oversee the development and maintenance of all physical safety programs on site including Lockout/Tagout, Confined Space, Powered Industrial Trucks, working at heights, Hot Work and Warehouse safety. Oversight of the sites Fire Prevention plan Hazard identification and mitigation through risk assessments, job hazard assessments, personal protective equipment assessments and workplace evaluations Provide HS&E guidance on small projects, and tenant improvement projects. Plan and deliver safety training for employees, focusing on key areas of responsibility Conducting HS&E Inspections and program audits ensuring the company's adherence to regulatory and safety standards. Working proactively and collaboratively with all team members in a matrix project format to ensure that HS&E Program and project goals are met Lead incident investigation process, including root cause analysis and identification of corrective action plans REQUIREMENTS: B.S. in Physical and/or Life science, engineering, environmental or public health 5+ years of experience in biotech/pharmaceutical, construction or a related industry Familiar with Cal/OSHA and related regulatory requirements for Physical Safety Programs including LOTO, Confined Space, Powered Industrial Trucks, Electrical Safety, Working at Heights etc. Please visit our website, ******************** Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************* The pay scale for this position is $72,834 to $128,826 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Are you ready for a new beginning? We need your talent, knowledge and dedication to better our world with biology. Our purpose points the way In Novonesis, we know that solutions rooted in biology can help solve humanity's biggest challenges. Since we began more than a century ago, this has been our guide. It's how we've gotten so far. And it's how we'll impact the future. Now, more than ever, the world needs change. And with biosolutions, the possibilities for transformation are endless. We're here to better our world with biology. Join us as our new Account Manager This position works under limited direction and is primarily responsible for the sale of culture and enzyme products into strategic food manufacturing customers (cheese, cottage cheese, sour cream, yogurt etc) with an assigned territory (Central Valley, CA). Other responsibilities include providing customer service on related products and accounts as well as in field technical assistance. This role will report directly to the Director of Sales - Dairy East. The Account Manager will work in close collaboration with Strategic Account Managers that create strategy and aid in setting the direction for the set of strategic customers in this region. Whenever possible the Account Manager will promote and sell other business unit products, or work closely with the Account or Technical Services Manager from another business unit. In this role you'll make an impact by: * Meeting or exceeding sales budget targets on a year-to-year basis. * Securing existing business from regular customers and finding new business from prospective customers. * Negotiating contracts and other legal documents involving in-depth product, industry, pricing and competitive information. * Formulating and recommending an in-depth account strategy for assigned territory based on customer needs and requirements and carrying out as approved. * Maintaining and protecting current business with customers utilizing business retention model * Providing technical know-how and assistance during trials, product launches, troubleshooting product performance and process changes * Maintaining multi-level contacts with key customers; keeping them informed of price trends, new products and new uses in the development of sales. * Developing a margin improvement strategy at each of the defined accounts in conjunction with sales management. * Troubleshooting customer concerns and solves routine industry problems on-site (i.e. new products and uses, marketing efforts, new facilities, price trends). * Informing management of any significant developments immediately. * Providing timely reports and information as required by management. * Utilizing key selling strategies and creates corporate selling strategy plans as needed To succeed you must hold: * Possess an in-depth understanding and experience in cheese making (Pasta filata, Hard Italian, Cottage Cheese preferred), dairy manufacture or fermented milk production * Possess good negotiation and follow-up skills. * Ability to develop, plan, and implement short and long range goals. Must have technical skills to know the right questions to ask of customers. * Must be a self-starter with drive and initiative and work with little supervision. * Must have a passion for the food industry. * Possess a working knowledge in Microsoft Office programs. * Ability to travel up to 60% of working time. * These characteristics are normally acquired through a Bachelor's degree in a scientific field, food technology or chemistry preferred, and a minimum of five years of sales experience. Application Deadline: 6/13/25 Could our purpose be yours? Then apply today! At Novonesis we commit to an inclusive recruitment process and equality of opportunity for all our job applicants. We recommend you not to attach a cover letter to your application. Instead, please include a few sentences in your resume/CV about why you are applying. To ensure a fair recruitment process, please refrain from adding a photo in your resume/CV. Novonesis is committed to creating a diverse environment and is proud to be an equal opportunity and affirmative action employer. All employment decisions are based on business needs without regard to race, color, ethnicity, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, disability, or veteran status. Want to learn more? Learn more about Novonesis, our purpose, and your career opportunities at novonesis.com Not the right fit for you? Even if this job isn't the right fit for you, perhaps you know someone who might find it interesting. If so, please feel free to share the job link and encourage them to apply. Thank you for your referral! Please check out our other open positions. The right fit for you could just be a few clicks away.

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! SR. SCIENTIST /ASSISTANT DIRECTOR, ANALYTICAL DEVELOPMENT & QUALITY CONTROL Seeking an experienced analytical chemist to join our AD/QC group at the Sr. Scientist or Assistant Director level. The ideal candidate will be a self-starter, familiar with a broad range of analytical techniques, possess a strong work ethic, have good communication skills, and have experience working in a GMP environment. The successful candidate will be able to perform the following responsibilities with a high degree of independence and attention to detail. RESPONSIBILITIES: * Coordinate and execute testing of drug substance intermediate, drug substance, and drug product samples * Develop drug substance specifications ensuring efficient integration across Chemistry, Manufacturing, and Controls (CMC) and other relevant disciplines such as Clinical and Toxicology * Author scientific reports and portions of the CMC section of regulatory filings * Manage the analytical activities for oligonucleotide therapeutic development projects * May develop and optimize analytical methods * Design and execute method validation and method transfer protocols * Manage outsourced analytical activities at external contract labs * Conduct analytical investigations * Present at internal and cross-functional scientific meetings REQUIREMENTS: * BS or MS with at least 5 years (Sr. Research Associate) or 10 years (Assistant Director) of industry experience in Analytical Chemistry or related discipline * Ph.D. with at least 2 years (Sr. Scientist) or 7 years (Assistant Director) of industry experience in Analytical Chemistry or a related discipline * Skilled in operating LC-MS, HPLC, and GC for the analysis of drug substance and drug product samples * Good understanding of the drug development process * Practical knowledge of GMP requirements, with hands-on GMP experience preferred * Good understanding of ICH and FDA method validation guidelines, including phase-appropriate strategies * Ability to problem solve, manage priorities and maintain aggressive timelines for multiple projects * Ability to work productively and independently within a team or matrix environment * Good written and verbal communication skills Please visit our website, ******************** for more information about Ionis and to apply for this position; reference requisition #IONIS003553 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************ The pay scale for the Sr. Scientist level is $111,231 to $146,000 The pay scale for the Assistant Director level is $114,441 to $162,000 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! RESEARCH ASSOCIATE, NEUROLOGY SUMMARY: We are seeking a motivated and skilled individual to join our Neurology Research group and participate in drug discovery for rare and severe disorders with high unmet medical need. Key responsibilities include administration of antisense oligonucleotides (ASOs), tissue sample processing, data collection, and analysis. The successful candidate will have demonstrated aptitude for laboratory work with a strong commitment to the scientific process and will be capable of working independently in a fast-paced environment. RESPONSIBILITIES: * Contribute to in vivo studies in wild-type and transgenic rodents to screen drug compounds for efficacy and tolerability, including preparing dosing solutions, dosing compounds, and performing necropsies * Generate biochemical analyses in the wet lab using techniques such as RT-qPCR and western blotting * Laboratory-based experimental research, including but not limited to RNA extraction, qPCR, and small rodent surgeries * Prepare data presentations and help interpret findings in order to identify the best drug candidates for use in human clinical trials * Manual and computerized data entry REQUIREMENTS: * B.S./M.S. degree in Biology or related field * Experience with standard molecular biology techniques strongly preferred * Experience with rodent surgery/handling preferred * Strong organizational skills, good record-keeping and meticulous attention to detail * Ability to work both independently and as part of a laboratory team * Excellent written and oral communication skills Please visit our website, ******************** for more information about Ionis and to apply for this position; reference requisition # IONIS003782 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************ NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

pspan /span/p pHeadquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals./p pspan /span/p pAt Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. /p pspan /span/p pWith an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. /p pspan /span/p pWe're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!/p pspan /span/p p style="text-align: center;"spanstrong PAYROLL ANALYST II/strong/span/p pspan /span/p pspanstrong SUMMARY:/strong/span/p pWe are seeking an individual with the knowledge and expertise to effectively support payroll activities for 1,000+ multi-state and global employees. This position requires working effectively and efficiently in an environment that demands high productivity while meeting multiple deadlines within very tight schedules./p pspanstrong RESPONSIBILITIES:/strong/spanspan /span/p ul li Bi-weekly payroll processing for 1,000+ employees using UKG Pro and UKG Time Management ul li Review and process timesheets to ensure accurate payment of work hours and paid time off (vacation, holiday, sick and volunteer time)/li li Calculate manual checks, leave of absence pay and terminations/li li Process payroll related employee changes (FTE/FLSA change, name/address change, work authorization change, direct deposit change, garnishments, etc.)/li li Ensure payroll reports are reviewed and balanced timely/li li Reconcile and prepare 401(k) and HSA funding/li li Maintain bi-weekly 401(k) contribution spreadsheet/li /ul /li li Monthly payroll processing for global employees using ADP/Celergo/li li Process stock transaction payrolls for nonqualified stock exercises and RSU releases/li li Conduct weekly New Hire Orientation/li li Maintain strict confidentiality with compensation related information/li li Create, research, and resolve UKG Pro support cases and service requests/li li Maintain related files and records in compliance with company and Sarbanes Oxley (SOX) requirements/li li Ensure compliance with federal, state, and other regulatory requirements/li li Generate reports, conduct specialized research projects, and respond to inquiries as required (benefit audits, workers' comp audits, etc.)/li lispan Other duties as assigned/span/li /ul pspanstrong REQUIREMENTS:/strong/span/p ul li Bachelor's degree in related field or equivalent experience/li li3+ years in a payroll support position/li li Experience with UKG Pro and UKG Time Management preferred/li li Experience with Morgan Stanley (E*Trade) Equity Edge Online preferred/li li Experience with SAP Success Factors Payroll a plus/li li Intermediate/Advanced Microsoft Excel skills (vLookup and Pivot Table functions at a minimum)/li li Demonstrated knowledge of Federal and State Labor laws, pay practices and policies/li li Exceptional attention to detail/li li Strong people skills and a positive attitude/li li Outstanding organizational skills with the ability to multi-task and prioritize/li li Strong work ethic and an ability to be productive and successful in an intense work environment/li li Required to be onsite in Carlsbad, CA a minimum of three days per week/li /ul p /p p style="text-align: center;"Please visit our website, a href="********************* rel="noopener" target="_blank"********************** for more information about Ionis and to apply for this position; reference requisition # span IONIS003615/span/p p style="text-align: center;"Ionis offers an excellent benefits package! Follow this link for more details: a href="************************************************************************************************************************* rel="noopener" target="_blank"strong Ionis Benefits/strong/a/p p style="text-align: center;"spanstrong Full Benefits Link:/strong/spanspan a href="************************************************************************************************************************* rel="noopener" target="_blank"********************************************************************************************************************************* p style="text-align: center;"span The pay scale for this position is $57,645 to $82,851/span/p p style="text-align: center;"NO PHONE CALLS PLEASE. PRINCIPALS ONLY./p p style="text-align: center;"em Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers./em/p

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! IT Operations Analyst III Position Overview: Ionis Pharmaceuticals is seeking a highly skilled and experienced IT Operations Analyst III to join our dynamic IT team. The successful candidate will play a pivotal role in optimizing and managing IT operations to ensure maximum efficiency, reliability, and security across the organization. This position involves providing advanced Level 2 and Level 3 support for line-of-business applications, including Office 365 administration, Okta, Entra, SharePoint, Veeva, and Cayosoft account creation. Responsibilities also include diagnosing and resolving complex technical issues, monitoring system performance, supporting high-profile meetings such as inspections, audits, and data readouts, and implementing strategic improvements to enhance our IT infrastructure and end-user support. The IT Operations Analyst III will collaborate closely with cross-functional teams to evaluate IT requirements and deliver tailored technical support to meet business needs. Key responsibilities include developing knowledge base articles, creating and maintaining L0 self-help video documentation for our user base, and conducting regular analysis of problem trends to identify solutions or process improvements. Staying abreast of emerging industry trends and technologies, such as security behavior and culture programs and generative AI to automate and optimize IT operations, is crucial for driving innovation and maintaining a competitive edge while maximizing resource output. The ideal candidate will possess a proven track record in IT operations, particularly within the biotech and life sciences sector, demonstrating a deep understanding of industry-specific IT challenges and regulatory requirements. They should have a history of successfully managing IT infrastructure, optimizing service delivery, and implementing strategic process improvements that enhance overall efficiency. The candidate must excel in diagnosing and resolving technical issues, proactively identifying areas for improvement, and driving technological innovation within a complex and fast-paced environment. Strong leadership, collaboration, and communication skills are essential, as well as the ability to adapt to evolving business needs while ensuring consistent, high-quality IT support and service. The IT Operations Analyst III is responsible for delivering advanced Level 2 and Level 3 support to internal customers, addressing complex issues related to computer hardware, software, and networked systems. This role involves proactively identifying, managing, and resolving events, incidents, and problems to minimize business disruptions and ensure the rapid restoration of normal service operations. Key responsibilities include managing technical service activities and coordinating with both internal teams and outsourced service providers to deliver high-quality technical solutions and support. The Analyst will deliver technical support for a range of platforms and applications, including Windows 10, Windows 11, mac OS, iOS, Office 365, Okta Administration, Zoom Administration, SharePoint, SAP, Veeva, Adobe Sign, Adobe Acrobat, Azure AD, Copilot, Intune, and scientific tools such as GraphPad Prism, ChemStation, ChemDraw, JMP, Mimecast Administration, and Microsoft Teams. This is an on-site position, Monday through Friday, with some after-hours support required, maintaining a physical presence in the office in which candidate is hired (Carlsbad, Boston, Dublin). Onsite support includes hardware and software support, white glove C-suite support, and conference room technical support. Additionally, the IT Operations Analyst III will use remote tools such as TeamViewer Quick Support to assist and support the remote user base across the United States and Europe. The Analyst will utilize ticketing systems such as SolarWinds Service Desk to manage and resolve issues, demonstrate proficiency with Microsoft Teams, manage IT inventory and assets effectively, conduct end-user training including new hire orientation, maintain the service desk knowledge base, and be proficient in process documentation. Experience with Cayosoft Administrator Console, on-prem Active Directory, Exchange Online administration, and mobile phone support (e.g., Verizon admin console, Apple Business Manager) is also required. Vendor and MSP Management: • Serve as the primary point of contact for Managed Service Providers (MSPs) and third-party vendors supporting IT operations. • Establish and maintain strong relationships with vendors to ensure high-quality service delivery and adherence to SLAs. • Evaluate vendor performance, review contracts, and recommend renewals or replacements as necessary. • Collaborate with procurement teams to manage IT-related vendor contracts, budget forecasting, and service agreements. • Work with external partners to optimize support processes, implement improvements, and ensure seamless integration with internal IT functions. Team Collaboration: The IT Operations Analyst III will work closely with various teams across the organization to ensure seamless IT operations. Cross-Functional Collaboration: Partnering with departments such as R&D, HR, and Finance to understand their IT needs and provide tailored support. Project Teams: Participating in IT projects, contributing technical expertise, and ensuring project goals are met on time. Vendor Coordination: Managing relationships with external service providers to ensure high-quality service delivery and support. Knowledge Sharing: Collaborating with team members to share knowledge, best practices, and provide mentorship to junior staff. Regular Meetings: Attending and contributing to regular team meetings to discuss ongoing issues, upcoming projects, and continuous improvement initiatives. Experience: A bachelor's degree in information technology, computer science or equivalent field preferred A minimum of 5 years of experience in the IT industry required, 3+ years of experience with master's degree Proven experience in IT operations, particularly in service desk support, incident management, and vendor management. Requirements: Exceptional customer service skills to facilitate effective communication with internal stakeholders. Strong problem-solving capabilities to efficiently prioritize and resolve technical issues. Proficiency in Office 365 administration, including expertise in user and license management. Hands-on experience with identity and access management tools, such as Okta and Microsoft Entra. In-depth knowledge of SharePoint administration, including maintenance and troubleshooting. Familiarity with tools like Veeva and Cayosoft for account creation and management. Comprehensive understanding of network connectivity principles and troubleshooting techniques. Proven ability to diagnose and resolve application errors and performance-related issues. Demonstrated project management skills, considered highly advantageous. Experience in administering ticketing and incident management tools, such as SolarWinds Service Desk. Demonstrated adaptability, with a strong drive to explore and implement technology-based solutions. Exceptional verbal and written communication skills, enabling effective interaction with stakeholders at all levels of the organization. Proven ability to work collaboratively as a strong team player, fostering a positive and productive team environment where ideas and concepts are constructively challenged to achieve the best outcomes. Please visit our website, ******************** for more information about Ionis and to apply for this position; reference requisition #IONIS003549 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************ The pay scale for this position is $84,012 - $112,976 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. #LI-Onsite - Carlsbad, CA or Boston, MA, or Dublin, Ireland

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! ASSOCIATE DIRECTOR, DATA MANAGEMENT & GOVERNANCE SUMMARY: We are seeking an Associate Director, Data Management & Governance to serve as a domain-driven, techno-functional lead within the Global Product Strategy and Operations (GPSO) IT team. This critical role involves managing customer data and overseeing data governance and analytics for Commercial and Medical business units. This cross-functional role is ideal for someone who combines deep domain knowledge with operational excellence across all aspects of commercial and medical affairs and thrives on identifying how data can support business outcomes. The candidate will drive the adoption of data governance tools and practices to improve data discoverability, accessibility, and auditability across the commercial landscape. A strong understanding of customer domains including HCP, HCO, Payer, Provider, Provider, Product etc. is critical to support use cases across all field-facing functions. RESPONSIBILITIES: MDM Ownership Product ownership of the end-to-end MDM strategy and operations across HCP, HCO, payer, provider, and patient domains using Veeva Network for both Commercial and Medical business units. Manage and own the support and evolution of alignment and roster modules Lead Data stewardship, data quality monitoring, and standards enforcement in alignment with enterprise and field analytics needs. Integrate and master third-party data sources (e.g., IQVIA, Komodo, Compile, Symphony, HCP lists, RWE providers) and orchestrate enrichment flows for real-world applicability. Data Governance Design, implement and lead a scalable data governance framework for GPSO, including policies, data ownership models, stewardship processes, and metadata management Serve as the IT owner for data domain councils and data stewardship communities, facilitating collaboration across business and technical teams Contribute to the broader data strategy by aligning MDM/governance capabilities with enterprise architecture, security, and analytics infrastructure Collaborate with data privacy, security, and compliance teams to ensure adherence to regulations (e.g., HIPAA, GDPR, CCPA). Cross-Functional Collaboration Partner with Commercial (business units such as Sales, Marketing, Market Access, Patient Services, HEOR) and Medical (Medical Affairs and Field medical) business stakeholders to define use cases and ensure high-quality, fit-for-purpose data delivery. Collaborate with IT teams supporting data warehouse, omnichannel, and reporting platforms to maintain integrated, high-quality data flows. Participate in enterprise data governance councils and represent GPSO IT in cross-functional data working groups as needed. Operational Execution Lead vendor management for MDM services in support of adhering to quality SLAs and timely issue resolution. Lead and support both intra- and inter- application integrations for GPSO applications like MDM, CRM, Omnichannel and analytics systems Document processes, standards, issue logs, and metrics related to MDM operations and governance. REQUIREMENTS: Bachelor's degree in information technology, Computer Science, or related field. At least 12 years with a bachelor's degree; 8+ years with a master's; or 5 years with a PhD with experience in data management and at least 7+ years in life sciences Proven hands-on expertise with Veeva Network, including mastering logic, affiliations, change requests, and hierarchy management. Deep subject matter expertise in core data domains, including: HCP/HCO: Credential validation, specialty, practice affiliation, address management, and territory mapping. Payer: Plan hierarchies, formulary status, reimbursement structures, and payer-plan influence models. Provider: Institutional relationships, referral networks, site capabilities, and group practice linkages. Patient (is a plus but not required): Relevant to data flows from specialty pharmacy, hubs, or external data partners. Understanding and experience with how these domains power field analytics, segmentation, targeting, omnichannel strategy, and insight generation Understanding Veeva CRM, Salesforce, Omnichannel or other commercial/medical CRM platforms. Experience leading data governance, stewardship, and quality programs Experience implementing cloud-native MDM pipelines using Databricks, SQL, Python, Delta Live Tables, and APIs. Knowledge of HIPAA, Sunshine Act, and regulatory data handling requirements for pharmaceutical companies. Strong stakeholder communication skills and the ability to translate business needs into technical design. Excellent communication skills to translate data topics to business stakeholders and vice versa. Comfortable working in Agile and product-driven development environments PREFERRED QUALIFICATIONS: Familiarity with Power BI/Tableau, or other reporting tools. Experience working with or supporting field teams in rare disease or specialty pharma environments. Familiarity with third-party data vendors (e.g., MMIT, SHS, LexisNexis, Definitive Healthcare) for payer/provider enrichment. Relevant certifications (e.g., ITIL, PMP) Please visit our website, ******************** for more information about Ionis and to apply for this position; reference requisition # IONIS003735 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************ The pay scale for this position is $138,744 to $200,000 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. #LI-Remote

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! POSTDOCTORAL RESEARCHER - CARDIOVASCULAR GENE EDITING/ DELIVERY SUMMARY: We are seeking an enthusiastic postdoctoral scientist interested in using CRISPR gene editing to address root causes of heart failure and arrhythmia to join the Cardiovascular Drug Discovery group, a multi-disciplinary team of energetic researchers. The successful candidate will work in a matrix group environment to explore in vivo gene editing for cardiovascular diseases. He/She will work independently to conceptualize, design and execute experiments using rodent and human cell models. Background in RNA, molecular biology, and CRISPR/Cas systems are essential for the position. Experience in cardiovascular biology and drug delivery is a plus. RESPONSIBILITIES: Design, execute and troubleshoot experiments relevant to the postdoctoral project Formulate solutions for delivery of therapeutics in vitro and in vivo and contribute to optimization. Measure and analyze pharmacodynamic and functional effects of treatments in rodent and cell models of disease. Present results at internal and external scientific meetings. Prepare manuscript for publication. REQUIREMENTS: Ph.D. in molecular biology, biochemistry, or related fields with 0-3 years of postgraduate training. Strong laboratory skills in molecular biology and biochemical assays, e.g. RNA and protein isolation, RT-qPCR, ELISA, Western Blotting. Proficiency in rodent handling, dosing (IV, SC, IM) and necropsy. Hands-on experience with CRISPR/Cas systems. Excellent written and verbal communication skills. Required to be full-time onsite at Carlsbad, CA. PREFERRED SKILLS: Experience with in vivo imaging systems (IVIS) is desirable. Exposure to non-viral vector in vivo delivery desirable. Experience with lipid formulation for in vivo and in vitro delivery. Experience with cardiomyocyte culture (primary and/or iPSC-CMs). Exposure to cardiac functional assessments, including echocardiography. Experience with confocal microscopy. Please visit our website, ********************* Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************* The pay scale for this position is $78,000 to $87,000 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. #LI-Onsite

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! DIRECTOR, MEDICAL EVIDENCE GENERATION, CARDIOMETABOLIC THERAPEUTIC AREA SUMMARY: The Director of Medical Evidence Generation will be responsible for executing Ionis' medical evidence generation strategy within the cardiometabolic therapeutic area. This role will involve working closely with cross-functional teams including Medical Affairs, Clinical Development, HEOR, and Commercial teams to design and conduct epidemiology studies/analyses, observational research studies, develop disease and product registries, and design and implement Phase 4 studies. This role will report to the Executive Director of Medical Evidence Generation. RESPONSIBILITIES: Design and execute evidence generation activities that will fill priority evidence gaps identified in asset-specific Integrated Evidence Generation Plans (IEGPs). Design and lead observational research studies to evaluate real-world effectiveness and other outcomes. Develop and maintain disease and product registries, including collaborative registries with academic institutions, patient advocacy groups, or other external organizations. Design and implement Phase 4 study designs, including observational studies, to generate additional medical evidence for marketed products. Apply causal inference expertise to ensure robust analysis of observational data to support evidence-based decision-making. Collaborate with cross-functional teams including Medical Affairs, Clinical Development, HEOR, and Commercial teams to ensure that medical evidence generation activities are aligned with the overall business objectives. Present medical evidence to internal and external stakeholders, including at scientific conferences, and other relevant forums. Stay up-to-date with the latest developments in epidemiology, observational research, registry methodologies, Phase 4 study designs, and advanced analytical methods, and incorporate them in Ionis' medical evidence generation activities. REQUIREMENTS: A PhD or Master's degree in epidemiology, public health, HEOR, or related field with at least 8 years of experience (PhD level) or 12 years of experience (Master's level) in the pharmaceutical industry. Extensive experience designing and leading observational research studies, including the use of real-world data. Demonstrated expertise in developing and maintaining disease and product registries. Strong knowledge of Phase 4 study design and implementation. Strong knowledge of causal inference methods, including propensity scores and instrumental variables. Strong analytical and problem-solving skills. Strong publication record. Excellent verbal and written communication and presentation skills. Ability to work collaboratively with cross-functional teams. Ability to work independently and manage multiple projects simultaneously. If you are passionate about using medical evidence to improve health outcomes for patients and have appropriate qualifications, we encourage you to apply for this exciting opportunity. Please visit our website, ******************** for more information about Ionis and to apply for this position; reference requisition # IONIS003730 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************ The pay scale for this position is $233,662 to $260,000 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. #LI-remote

pHeadquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals./p pAt Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. /p pWith an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our work environment a place where solid and lasting relationships are built and where our culture and employees can thrive. /p pWe're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!/p p style="text-align: center;" /p p style="text-align: center;"strong MANAGER / SENIOR MANAGER - GXP QUALITY SYSTEMS (QA VENDOR MANAGEMENT)/strong/p pspan /span/p pspanstrong SUMMARY:/strong/span/p pWe are seeking an experienced Manager / Sr. Manager with strong knowledge and expertise in Vendor Management and Internal Audits Programs. The ideal candidate will be highly motivated, detail-oriented, inquisitive, and can drive activities, assignments, and tasks to completion in accordance with established expectations and timelines. This role is for an individual contributor reporting to the Assistant Director, GxP Quality Systems (QA Vendor Management)./p pPrimary responsibilities will focus on operational execution of vendor management activities (e.g., vendor on- and off-boarding, service provider / vendor qualification, auditing, performance monitoring, and measurement / metrics), working with multi-disciplinary and cross-functional teams regarding change and quality event management (including CAPA), internal audits, material qualification, quality agreement preparation and management, and risk management./p pPreference will be given to candidates possessing strong compliance and Quality System experience (including QA applications), and knowledge of domestic and international cGMP regulatory requirements (e.g., FDA, Eudralex, Health Canada, ICH, MHRA, MHLW, etc.). Experience with small molecules, biologics, medical devices and / or combination products is desired. Candidates must also have excellent verbal and written communication skills, and strong analytical and problem-solving abilities to address issues of moderate complexity. Furthermore, the candidate must be able to work in a dynamic and fast-paced environment, be a team player, maintain professionalism, and be able to work with multi-disciplinary, cross-functional teams on high impact projects delivering quality results in accordance with agreed upon timelines. This onsite / hybrid role will be based in our headquarters office located in Carlsbad, CA.span /spanspan /span/p pspanstrong RESPONSIBILITIES:/strong/span/p ul li Lead and execute Vendor Management Program processes in accordance with the established risk-based model ensuring there is no interruption to business activities./li li Manage and track new Vendor Requests including working with our customers / stakeholders regarding risk assessment and scoring and delivering results in accordance with agreed upon business timelines./li li Strong knowledge and experience with planning, preparing, conducting, and documenting cGMP Vendor and Internal Audits (including onsite, remote and questionnaire audits) in accordance with applicable domestic or international regulatory requirements and industry best practices./li li Manage Vendor Change Notifications collaborating with customers / stakeholder regarding impact and quality assessments and ensuring adherence to vendor change timelines and internal / regulatory requirements, as applicable./li li Perform quality event investigations including CAPA development and Effectiveness Checks, as required./li li Lead and manage Quality Agreement Program. Initiate, negotiate, establish, and periodically update new and existing agreements with our cGMP vendors, as applicable./li li Adheres to standard process lead times and ensures alignment with key performance indicators and relevant measures / metrics./li li Strong intra- / inter-company communication skills, ability to think critically and influence others, and problem solve, and possesses solid technical writing skills./li li Ability to work independently, is organized, can multi-task and adjust priorities in a fast-paced, dynamic work environment./li lispan Collaborate or lead projects that drive continuous quality improvements, implement best practices and /or enhance compliance to domestic and international regulatory requirements./span/li /ul pspanstrong REQUIREMENTS:/strong/spanspan /span/p ul liB.S. in Chemistry, Chemical Engineering, or related discipline; advanced degree preferred./li li Manager: Requires a minimum of 3 years in the Life Sciences or Pharmaceutical industry with relevant Quality Assurance experience and 2+ years of GMP Vendor Management experience strongly preferred; or an advanced degree without experience; or equivalent work experience/li li Senior Manager: Requires a minimum of 5 years in the Life Sciences or Pharmaceutical industry with relevant Quality Assurance experience and 4+ years of GMP Vendor Management experience strongly preferred; or 3 years and a master's degree; or equivalent work experience/li li Knowledge of domestic and international cGMPs/li li Experience regarding quality event investigations, problem solving, and process improvement (with emphasis on cGMP compliance)/li li Focused on what matters and committed to delivering high quality results and resolving challenges and issues in a timely manner/li li Travel up to 15% may be required/li /ul pspan /span/p pspan /span/p p style="text-align: center;"Please visit our website, a href="********************* rel="noopener" target="_blank"********************** for more information about Ionis and to apply for this position; reference requisition #span IONIS003729/span/p p style="text-align: center;"Ionis offers an excellent benefits package! Follow this link for more details: a href="************************************************************************************************************************* rel="noopener" target="_blank"strong Ionis Benefits/strong/a/p p style="text-align: center;"spanstrong Full Benefits Link:/strong/spanspan a href="************************************************************************************************************************* rel="noopener" target="_blank"********************************************************************************************************************************* p style="text-align: center;"span The pay scale for this position is $73,618 to $120,971/span/p p style="text-align: center;"NO PHONE CALLS PLEASE. PRINCIPALS ONLY./p p style="text-align: center;"em Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers./em/p

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! ASSOCIATE DIRECTOR, OLEZARSEN HCP MARKETING SUMMARY: This pivotal marketing position represents an exciting opportunity to join a high-performing launch team. Olezarsen is a cornerstone asset in the Ionis portfolio and represents a realization of Ionis' long-term vision to become a fully integrated biotech company, serving patients from rare- to broad-prevalence indications. It is estimated there are more than three million people living with Severe Hypertriglyceridemia (sHTG) in the US. SHTG is a disease categorized by triglyceride levels of 500 mg/dL and above. Healthy triglyceride levels for adults are typically below 150 mg/dL. Levels of 150 mg/dL or higher are associated with an increased risk of heart disease, and as triglyceride levels continue to rise above 500 mg/dL there is an increased risk of pancreatitis, which can be dangerous. The current treatments are ineffective at adequately lowering TGs to safe levels. The Associate Director of Olezarsen HCP Marketing will specifically be responsible for HCP marketing strategy and tactical execution, and will play an integral role in the launch of olezarsen. Reporting to the Director of Olezarsen HCP Marketing, the ideal candidate will bring: biotech/pharma commercial launch experience, a curiosity to uncover and experiment with innovation, a commitment to collaboration, and a drive to deliver a successful launch. This is a highly visible, high-growth role that requires demonstrated strategic and tactical execution, superior cross- functional collaboration, and the ability to operate at all levels of the organization. This is a unique opportunity to participate at the start of the build-out of a commercial inline business that is positioned to have multiple launches in the coming years. Ionis is at the forefront of innovative science, defining and executing innovative and patient-centric solutions to deliver a transformational RNA Technology to patients with serious and fatal diseases. RESPONSIBILITIES: Guide important HCP initiatives aimed to shape the sHTG market, support a successful product launch, and drive brand growth. Lead key components of the planning and execution of launch and sales meetings. Create and deliver core disease state and branded elements, ensuring alignment with strategy and complimentary to other key audience engagement plans. Develop field sales materials and programs with consistent pull-through of aligned messages. Partner closely with other functions to prioritize, focus, and gain alignment on the most impactful campaigns and associated messaging to deliver brand objectives. Lead opportunities for external influence with HCPs, including speaker bureau, congress execution, and external speaking engagements. Develop, evolve, and optimize non-personal promotion in close collaboration with Omnichannel function, including websites, media drivers, emails, etc. Manage materials, projects, and resources through the internal review committee process (Promotional Review Committee). Oversee relationships with external creative and strategic agencies. Support the integrated strategic planning process (ISPP), including brand planning, tactical planning, and budget management. REQUIREMENTS: B.A. or B.S. required; MBA preferred. 8+ years of experience in pharma/biotech marketing with Bachelor's degree OR 6+ years of experience in pharma/biotech marketing with a Master's/advanced degree 4+ years of HCP-focused marketing preferred. Work experience in lipidology, and/or product launches is strongly preferred. Ability to deliver results in a fast-paced environment - through consistent effort, determination, teamwork, and ability to influence colleagues. Strategic thinking, including being creative in addressing key challenges, applying innovative ideas, and taking measured risks. Ability to successful project manage marketing initiatives. Strong organizational skills with excellent attention to detail. Ability to thrive independently and in ambiguity, with an entrepreneurial mind-set and with a track record of exploring new ways of working, driving new opportunities and catalyzing others to build creative solutions. Field sales/thought leader outreach experience. Ability to work effectively in a team-based organization, collaborate cross-functionally and exercise influence at all levels. Ability to build consensus and achieve agreement on key priorities, by conducting effective meetings, seeking broad input and feedback, and employing frequent and effective follow- up. Skilled at developing and delivering concise, relevant, and well-supported presentations or briefings. Strong analytical skills, demonstrated by the ability to identify and interpret complex issues and provide appropriate recommendations to senior management and across functional areas. Ability to travel (10-25%). Please visit our website, ******************** for more information about Ionis and to apply for this position; reference requisition # IONIS003720 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************ The pay scale for this position is $132,235 to $175,000 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. #LI-Remote

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We're pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We're building on our rich history, and we believe our greatest achievements are ahead of us. If you're passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! IT Operations Analyst III Position Overview: Ionis Pharmaceuticals is seeking a highly skilled and experienced IT Operations Analyst III to join our dynamic IT team. The successful candidate will play a pivotal role in optimizing and managing IT operations to ensure maximum efficiency, reliability, and security across the organization. This position involves providing advanced Level 2 and Level 3 support for line-of-business applications, including Office 365 administration, Okta, Entra, SharePoint, Veeva, and Cayosoft account creation. Responsibilities also include diagnosing and resolving complex technical issues, monitoring system performance, supporting high-profile meetings such as inspections, audits, and data readouts, and implementing strategic improvements to enhance our IT infrastructure and end-user support. The IT Operations Analyst III will collaborate closely with cross-functional teams to evaluate IT requirements and deliver tailored technical support to meet business needs. Key responsibilities include developing knowledge base articles, creating and maintaining L0 self-help video documentation for our user base, and conducting regular analysis of problem trends to identify solutions or process improvements. Staying abreast of emerging industry trends and technologies, such as security behavior and culture programs and generative AI to automate and optimize IT operations, is crucial for driving innovation and maintaining a competitive edge while maximizing resource output. The ideal candidate will possess a proven track record in IT operations, particularly within the biotech and life sciences sector, demonstrating a deep understanding of industry-specific IT challenges and regulatory requirements. They should have a history of successfully managing IT infrastructure, optimizing service delivery, and implementing strategic process improvements that enhance overall efficiency. The candidate must excel in diagnosing and resolving technical issues, proactively identifying areas for improvement, and driving technological innovation within a complex and fast-paced environment. Strong leadership, collaboration, and communication skills are essential, as well as the ability to adapt to evolving business needs while ensuring consistent, high-quality IT support and service. The IT Operations Analyst III is responsible for delivering advanced Level 2 and Level 3 support to internal customers, addressing complex issues related to computer hardware, software, and networked systems. This role involves proactively identifying, managing, and resolving events, incidents, and problems to minimize business disruptions and ensure the rapid restoration of normal service operations. Key responsibilities include managing technical service activities and coordinating with both internal teams and outsourced service providers to deliver high-quality technical solutions and support. The Analyst will deliver technical support for a range of platforms and applications, including Windows 10, Windows 11, mac OS, iOS, Office 365, Okta Administration, Zoom Administration, SharePoint, SAP, Veeva, Adobe Sign, Adobe Acrobat, Azure AD, Copilot, Intune, and scientific tools such as GraphPad Prism, ChemStation, ChemDraw, JMP, Mimecast Administration, and Microsoft Teams. This is an on-site position, Monday through Friday, with some after-hours support required, maintaining a physical presence in the office in which candidate is hired (Carlsbad, Boston, Dublin). Onsite support includes hardware and software support, white glove C-suite support, and conference room technical support. Additionally, the IT Operations Analyst III will use remote tools such as TeamViewer Quick Support to assist and support the remote user base across the United States and Europe. The Analyst will utilize ticketing systems such as SolarWinds Service Desk to manage and resolve issues, demonstrate proficiency with Microsoft Teams, manage IT inventory and assets effectively, conduct end-user training including new hire orientation, maintain the service desk knowledge base, and be proficient in process documentation. Experience with Cayosoft Administrator Console, on-prem Active Directory, Exchange Online administration, and mobile phone support (e.g., Verizon admin console, Apple Business Manager) is also required. Vendor and MSP Management: • Serve as the primary point of contact for Managed Service Providers (MSPs) and third-party vendors supporting IT operations. • Establish and maintain strong relationships with vendors to ensure high-quality service delivery and adherence to SLAs. • Evaluate vendor performance, review contracts, and recommend renewals or replacements as necessary. • Collaborate with procurement teams to manage IT-related vendor contracts, budget forecasting, and service agreements. • Work with external partners to optimize support processes, implement improvements, and ensure seamless integration with internal IT functions. Team Collaboration: The IT Operations Analyst III will work closely with various teams across the organization to ensure seamless IT operations. * Cross-Functional Collaboration: Partnering with departments such as R&D, HR, and Finance to understand their IT needs and provide tailored support. * Project Teams: Participating in IT projects, contributing technical expertise, and ensuring project goals are met on time. * Vendor Coordination: Managing relationships with external service providers to ensure high-quality service delivery and support. * Knowledge Sharing: Collaborating with team members to share knowledge, best practices, and provide mentorship to junior staff. * Regular Meetings: Attending and contributing to regular team meetings to discuss ongoing issues, upcoming projects, and continuous improvement initiatives. Experience: * A bachelor's degree in information technology, computer science or equivalent field preferred * A minimum of 5 years of experience in the IT industry required, 3+ years of experience with master's degree * Proven experience in IT operations, particularly in service desk support, incident management, and vendor management. Requirements: * Exceptional customer service skills to facilitate effective communication with internal stakeholders. * Strong problem-solving capabilities to efficiently prioritize and resolve technical issues. * Proficiency in Office 365 administration, including expertise in user and license management. * Hands-on experience with identity and access management tools, such as Okta and Microsoft Entra. * In-depth knowledge of SharePoint administration, including maintenance and troubleshooting. * Familiarity with tools like Veeva and Cayosoft for account creation and management. * Comprehensive understanding of network connectivity principles and troubleshooting techniques. * Proven ability to diagnose and resolve application errors and performance-related issues. * Demonstrated project management skills, considered highly advantageous. * Experience in administering ticketing and incident management tools, such as SolarWinds Service Desk. * Demonstrated adaptability, with a strong drive to explore and implement technology-based solutions. * Exceptional verbal and written communication skills, enabling effective interaction with stakeholders at all levels of the organization. * Proven ability to work collaboratively as a strong team player, fostering a positive and productive team environment where ideas and concepts are constructively challenged to achieve the best outcomes. Please visit our website, ******************** for more information about Ionis and to apply for this position; reference requisition #IONIS003549 Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Full Benefits Link: ************************************************************************************************************************ The pay scale for this position is $84,012 - $112,976 NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. #LI-Onsite - Carlsbad, CA or Boston, MA, or Dublin, Ireland