Ironwood Pharmaceuticals jobs in Boston, MA - 77 jobs

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you'll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We're passionate about innovation, inclusion, and supporting your growth-inside and outside the lab. Why Vertex? Real Projects: You'll work on assignments that make a real impact, not just busy work. Mentorship & Networking: Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career. Flexible & Supportive: We offer flexible work options with Flex @ Vertex and prioritize your wellbeing. Inclusive Culture: Collaboration and inclusion are embedded in everything we do. Career Launchpad: Build skills, explore career paths, and get guidance for your future career. Ready to apply? Submit your application and let's turn possibilities into reality! Your Impact The Vertex Supply Chain & Manufacturing co-op program is a 6-month experiential training program for students currently working towards an undergraduate or advanced degree in Supply Chain Management, Industrial Engineering, Finance, Business, or a related field of study. If you are passionate, collaborative, and growth-minded, a co-op at Vertex will help you gain meaningful experience in our Supply Chain functional areas and serve as a launchpad for your career. The application deadline for this co-op is October 31st. Please note that Vertex reviews applications on a rolling basis and reserves the right to close this job posting prior to the listed deadline. Applicants can expect to receive an update about their application before or shortly after the application deadline. Important Notice Regarding Internship and Co-op Inquiries At Vertex Pharmaceuticals, we are committed to providing a fair and structured recruitment process for all students interested in internship and co-op opportunities. To ensure consistency and equity, all student applications must go through our Early Talent Acquisition Team. Due to the high volume of interest, we are unable to respond to individual solicitation. Direct solicitation to Vertex employees- including senior leaders via email will result in removal from the recruiting process. We appreciate your enthusiasm and interest in Vertex. To be considered for internship or co-op roles, please apply directly through our official application channels. ( ********************************************************************* Thank you for respecting our process and helping us maintain a fair experience for all candidates. What you will be doing: A Supply Chain & Manufacturing Co-op at Vertex is responsible for a wide variety of administrative activities within Commercial Supply Chain. Activities typically consist of well-defined support tasks that are performed independently as well as projects of increased complexity completed under close supervision. We will have various positions within our Supply Chain & Manufacturing functional areas, including but not limited to: Commercial Supply Chain: This role will work closely with Finished Goods, Drug Product and Upstream Material teams to assess inventory levels, Open Purchase Orders and Material Movements. This role will create a reporting tool to track current and projected on-hand inventory levels with expiry and inventory value data. External Manufacturing: External Manufacturing Operations (ExM) is responsible for managing the operations of Vertex's commercial external manufacturing network. Logistics: Logistics & Distribution team is responsible for planning and execution of shipments in support of Vertex's Cell and Gene therapy programs Manufacturing Science and Technology: The Manufacturing Sciences and Technology Small Molecule Drug Product department is tasked with launch and lifecycle management of Vertex commercial medicines. Operational Excellence: The mission of the Operational Excellence team is to help establish manufacturing and supply chain as strategic enablers for Vertex's growth. The Co-op will manage operational excellence initiatives supporting manufacturing and/or supply chain. Project Management: This position will be complimentary to a project coordinator and will take on a project to support process optimization efforts. Duties will include defining a problem, gathering customer requirements, measuring and analyzing processes, and implementing improvement projects. Risk Management: The Risk Management team works closely with multiple stakeholders within CMSC, Quality Assurance, Third Party Risk Management Office, and Corporate Risk Management to ensure we have adequate mitigation plans in place for all known risks, and tracks adherence to mitigation action due dates. What you will need to succeed: Enrolled in an undergraduate or graduate program in Supply Chain Management, Industrial Engineering, Finance, Business, or a related field of study Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization. You must be enrolled in an advanced degree program if graduating before June 2026 You must be available to work full-time, 40 hours per week from January - June 2026 Program Details: Full-time, paid co-op $20.00 - 35.00 USD/hour Program Dates: January - June 2026 Application Deadline: October 31st, 2025 At Vertex, we believe that when you feel your best, you can perform at your best. That's why our US benefits and global well-being resources are designed to support you. • Free 24/7 onsite gym access and free access to group exercise classes • Subsidized commuter benefits- transit and parking • Provided meals-free breakfast daily! • Career development opportunities and events, including C Suite engagement • Social events-both intern-only and company-wide • Location-specific perks and extras! • Recognition of National Intern Day Equal Opportunities Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Vertex is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. Accessibility & Accommodations We're focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Vertex is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Export Control Notice This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant's ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role, Vertex is unable to sponsor non-U.S. persons to apply for an export control license. This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer. For any questions or concerns, please contact early_***************. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Director, Safety Scientist plays a leadership role within Global Patient Safety organizing and mentoring safety scientists to actively evaluate, manage and strategize risk in collaboration with the GDS Medical Directors and cross-functional team members within the global regulatory framework. You will be responsible for: Leading risk management evaluation and resolution for assigned products and projects. Accountability for the following: Proven skill set for strategic leadership in a cross functional matrix Organize, train and/or support junior safety scientists and fellows across multiple product portfolios and/or indications Co-lead activities related to new drug applications and other regulatory filings Represent global patient safety at regulatory inspections i.e. MHRA, FDA, EMA, etc. Lead analysis to identify and address changes in global regulations including updates to SOP and process documentation Leading activities to identify and address process gaps Responsible for vendor management and training including budgets Responsible for overall project distribution across therapeutic area As needed represent GPS in global program teams and associated cross functional teams and/or projects Proactively provide guidance and educational training to GPS therapeutic teams Participate in ongoing safety data review and analysis for products in designated therapeutic areas. Responsible for Signal Review Meeting and Signal Management Team activities in collaboration with GPS Medical Directors Responsible for project managing and authoring of safety documents including PSUR, PBER, PADER, RMP, REMS, CSRs, and ad hoc requests in collaboration safety physicians. Responsible for authoring safety section in collaboration with team members on regulatory responses, IBs/CCDS, protocol, ICF review, Data Monitoring Committees reports and requests, and other documents, and provide the necessary quality control to ensure alignment with core safety position. Manage portfolio of products/projects related to risk management; assists Safety Physicians in the development of risk management strategy and activities for assigned products You will have: Advanced degree in a biologic/medical/clinical/nursing field: Pharmacist/PharmD, Nurse Practitioner or PhD with at least 7 years' experience in drug safety and risk management within the pharmaceutical, biotech or CRO industry Knowledge and understanding of US and EU safety regulations pre- and post- marketing Experience with Risk Management and Minimization programs Experience preparing post marketing safety regulatory documents including PSURs, PBRERs and Risk Management Plans Experience with clinical development including risk/benefit analysis and safety assessment Strong clinical, analytical, problem solving and scientific writing and communication skills We would prefer you have: Expertise with clinical and safety databases Experience in MedDRA coding and search strategies Excellent, independent judgment based on knowledge and expertise Strong personal time-management and project-management skills Mastery of Microsoft Word, PowerPoint and Excel The annual base pay for this position ranges from $175,000 to $263,000. Our positions offer eligibility for various incentives-an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Date Posted 18-Dec-2025 Closing Date 04-Jan-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

At AstraZeneca, we turn ideas into life-changing medicines. Working here means thinking big and working together to make the impossible a reality. We're focused on the potential of science to address the unmet needs of patients around the world. We commit to those areas where we think we can really change the course of medicine and bring big new ideas to life. At AstraZeneca, we are taking bold action on climate because we recognize the connection between healthy people and a healthy planet. As part of our flagship Ambition Zero Carbon program, we have committed to a fully electric vehicle (EV) fleet by the end of 2025, which means that all our drivers will be assigned an EV. As a Senior Pharmaceutical Sales Specialist for the Advanced Specialty Team, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. Accountabilities • Develop and demonstrate knowledge of clinical disease states and treatment guidelines. • Effectively communicate product information to healthcare professionals. • Analyze trends and develop strategic business plans, leveraging understanding of the market landscape, dynamics, and patient access challenges. • Provide solutions to customers by creating a tailored customer experience based on account and HCP needs. • Identify opportunities for process improvement, demonstrate openness to new ideas, and seek innovative approaches to sales and customer engagement. Essential Skills/Experience • Bachelor's Degree • 3+ yrs of demonstrated Sales or Commercial experience or a combination of: pharmaceutical, healthcare, scientific, clinical, institutional, or related industry / settings within the healthcare ecosystem • Experience in account planning and/or complex reimbursement model OR internal AZ certification • A valid driver's license and safe driving record Essential Skills and Capabilities • Advanced Therapeutic Area Expertise: Experience and expertise in highly specialized therapeutic areas • Customer Engagement: Proven ability to engage with senior-level healthcare professionals, including specialists and hospital administrators. • Innovative Sales Strategies: Experience in developing and implementing innovative sales strategies in a highly specialized market. • Clinical Acumen: Exceptional ability to understand and communicate cutting-edge scientific research and clinical data. • Strategic Partnerships: Experience in establishing and nurturing strategic partnerships with healthcare institutions and research organizations. • Business Acumen: Proficiency in advanced data analysis and the use of analytics to drive sales performance. At AstraZeneca, we are on a journey to bring life-saving medicines to patients. Our role in contributing to decreasing mortality rates globally is clear. We shape the future by spotting scientifically-led commercial opportunities and acting now to operationalize and scale them. Driven by the solutions we bring to the healthcare ecosystem, we make an impact at every step of the patient journey, improving their experience and outcomes. Our agile and entrepreneurial team of visionaries is trusted to innovate and experiment, supported to learn fast from failures and move on. Join us in making a difference - apply today! No relocation assistance provided The annual base pay for this position ranges from $76,935.20-$204,973.20, Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Date Posted 04-Dec-2025 Closing Date 30-Jan-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

The Quality Specialist will provide QA support for manufacturing operations, analytical laboratory operations, and materials management for the internal programs at Vertex Manufacturing Center (VMC), Boston, MA. The position will be a part of the QA operation floor support team. This role will review & support activities related to product disposition, including batch data, batch records, deviations, in-process data, EM data, QC release testing, and other quality systems documentation. The Quality Specialist supports or executes daily activities related to equipment or instrumentation supporting Facilities, Utilities, Manufacturing, and Labs. The position will support multiple production functions (from Quality operations to Quality Engineering) to achieve site goals while providing Quality oversight and ensuring compliance. Supporting resolution of potential nonconformance events by applying the deviation and CAPA management procedure, in conjunction with other procedures as applicable, to facilitate decision-making with a cross-functional team, as needed. Perform other duties as assigned by the management. This role will require a local presence at the VMC, Boston, MA site. Key Knowledge/ Skills and Competencies: Strong oral and written communication skills required Good Interpersonal skills required Attention to detail Knowledge in the following areas: Understanding of global GMP requirements governing oral drug products and knowledge of oral drug product manufacturing practices Oversight of Internal Operations - QA Operation and Compliance Act as a first point of contact in case of QA support for shipping and material transfer. Ensure regular presence in GMP operations areas as needed. Performs Line and area clearance. Responsible for raw material release. Review and approve batch production records and other GMP documentation in support of daily operations. Generate performance metrics, trends; including site metrics for investigation/CAPA, Equipment and Facility Change Controls, etc Participate in self-led inspections and provide support during internal/external regulatory inspections. Responsible for identifying risks and communicating gaps for GMP process/systems Support Lean Transformation and Operational Excellence initiatives Adhering to safety rules and maintaining a safe work environment for both you and others by supporting EHSS corporate and site goals Oversight of Internal Operations - Quality Engineering Provide Quality oversight and review of calibrations, PMs, eCRs, work orders and laboratory operations via instrument qualifications Support EM and UM programs and control programs Provide support for facilities and engineering projects, including capital projects, annual plant shutdowns, and various improvement projects as assigned Audit / Inspection Support Participate in inspection readiness activities and provide support during regulatory site inspections. Provide post-inspection support to address any regulatory observations. Deployment of QMS and Establishment of Compliance Expectations Participate in process improvement initiatives (as necessary), performing gap analysis and risk communication. Act as a trusted advisor to the site by providing compliance guidance through collaborative review and working with the business owners to gain a better understanding of their needs and facilitate the resolution of quality issues in a timely manner. Individual Development and Training Responsible for timely completion of trainings (100% on-time), goal development, self-evaluation and IDP Minimum Qualifications: M.S in life sciences (or equivalent degree), or B.S in life sciences (or equivalent degree) and 1-3 years of relevant work experience Ability to thrive in a high throughput environment. Preferred Qualifications: Affinity with digital innovation, data sciences, and Quality engineering Experience with raw material receipt and release, inspection & sampling Highly effective verbal and written communication skills, strong interpersonal skills Great attention to detail and high degree of accuracy in task execution and GMP documentation Ability to providing updates to senior management, and identifying potential issues Strong organizational skills, including ability to follow assignments through to completion Knowledge of ASTM E2500, CSV/GAMP, and other associated standards is a plus In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Pay Range: $35 - $53 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Medical Science Liaison (MSL), with support and guidance from peers and management, will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex's compounds in a timely, ethical and stakeholder-focused manner. The MSL will contribute to shaping the medical plan by providing external stakeholders' insights and contribute to the design and execution of the Medical Affairs strategy and plan. The MSL will engage HCPs in response to scientific educational and research needs with available Vertex resources and provide the latest emerging data in response to specific inquiries, as appropriate. • Through scientific exchange, develops trusting relationships with a predefined list of medical and scientific Thought Leaders and other HCPs • Applies principles of the Scientific Engagement Model (SEM) to enhance the quality of interactions as assessed by field coaching observations • Incorporates the medical plan (i.e. listening priorities) into interactions and captures feedback in the CRM system with appropriate oversight by management, to inform internal stakeholders and assist in shaping the medical strategy • With guidance from management, utilizes the CRM system and analytics reports to capture interaction details in a time sensitive manner and to enhance future TL engagements and manage workload • Exchanges scientific information effectively and compliantly with external stakeholders at a proficient level of communication for both disease state and product to external stakeholders as assessed by management coaching and field observations • Conceptual and practical knowledge of local and regional payers within the geography and understands the relationships between those plans and patient care delivery in the region • Assists clinical development/clinical operations by understanding IB content and presenting IB content and presenting IB material at SIV meetings, providing nominations for trial sites as requested, providing end of study data reviews with investigators as needed • With guidance from management, represents Vertex at medical congresses by providing scientific session/abstract coverage, booth staffing coverage, routine TL interactions, contributing to the daily and end of congress summaries • After initial guidance, independently performs and completes, in a timely manner, administrative tasks such as CRM entry, vehicle mileage reporting, expense reporting, calendar entries, trainings assignments, etc. and conducts all activities in compliance with Vertex Policy and Procedures Requirements: • Minimum requirement for advanced biomedical or life sciences degree (Masters, NP, PA) • Preference for terminal degree in the biomedical or life sciences (DO, MD, PharmD, PhD) • Requires a minimum of 3 years of experience as a MSL, or in other medical affairs roles in the pharma/biotech industry • Previous training or experience in designated therapeutic area is preferred Required Knowledge/Skills: • Ability to complete goals within allotted timeframes, and deliver high quality results • Ability to initiate, plan and complete projects in a constantly changing field-based environment • Ability to identify issues and create solutions • Ability to critically appraise and comprehend medical and scientific literature • Ability to effectively present clinical/scientific information in a credible manner in varied settings • Good knowledge and understanding of assigned geographic territory and healthcare regulatory environment • Ability to use Microsoft Office programs and to work in a matrix environment • Ability to apply knowledge of relevant disease and disease management protocols, healthcare environment and competitors to articulate the medical and scientific value of Vertex products • Demonstrated good understanding around the compliance and regulatory frameworks that govern the pharmaceutical industry and conducts compliant interactions with internal and external stakeholders. • Possess general working knowledge of payers and unique medical information needs to support access and appropriate use of Vertex medicines • Working knowledge of Health Economics and Outcomes Research • Has working knowledge of local/regional payers within geography and the relationships between those plans and patient care delivery in the region • Fluent in English & Local Language (oral and written) Pay Range: $150,400 - $225,500 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you'll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We're passionate about innovation, inclusion, and supporting your growth-inside and outside the lab. Why Vertex? Real Projects: You'll work on assignments that make a real impact, not just busy work. Mentorship & Networking: Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career. Flexible & Supportive: We offer flexible work options with Flex @ Vertex and prioritize your wellbeing. Inclusive Culture: Collaboration and inclusion are embedded in everything we do. Career Launchpad: Build skills, explore career paths, and get guidance for your future career. Ready to apply? Submit your application and let's turn possibilities into reality! Your Impact The Vertex Research internship program is a multi-week experiential training program for students currently working towards an advanced degree in Applied Mathematics, Computational Biology, Pharmaceutical Sciences, Chemical Engineering, or a related field of study. If you are passionate, collaborative, and growth-minded, an internship at Vertex will help you gain meaningful experience in our Drug Metabolism Pharmacokinetics functional areas and serve as a launchpad for your career. Important Notice Regarding Internship and Co-op Inquiries At Vertex Pharmaceuticals, we are committed to providing a fair and structured recruitment process for all students interested in internship and co-op opportunities. To ensure consistency and equity, all student applications must go through our Early Talent Acquisition Team. Due to the high volume of interest, we are unable to respond to individual solicitation. Direct solicitation to Vertex employees- including senior leaders via email will result in removal from the recruiting process. We appreciate your enthusiasm and interest in Vertex. To be considered for internship or co-op roles, please apply directly through our official application channels. (************************************************************************** Thank you for respecting our process and helping us maintain a fair experience for all candidates. What you will be doing: The Preclinical Modeling and Simulation (pM&S) team within the DMPK department uses mathematical models and computational tools to predict, optimize, and quantify the absorption, distribution, metabolism, and excretion of drug candidates. This intern position will work with the pM&S team to develop mechanistic and systems-based models of diseases for translational research purposes. Develop and implement quantitative systems pharmacology (QSP) models of relevant diseases in collaboration with the pM&S team Source modeling techniques and approaches from literature sources or design novel models as necessary to address questions and inform decision making across programs Collect relevant data from published sources as necessary for model calibration Present and discuss research progress with the pM&S team, DMPK, and other stakeholders as appropriate What you will need to succeed: Enrolled in a graduate program, majoring in Applied Mathematics, Computational Biology, Pharmaceutical Sciences, Chemical Engineering, or a related field of study. Significant experience (2-4 years minimum) using a programming language such as Matlab, Python, R, or Julia to numerically solve systems of ordinary differential equations is required for this position Experience designing and implementing ordinary differential equation-based models of biological systems, including parameter optimization using time-series data Experience importing, processing, and visualizing data using one of the programming languages listed above History of publication and/or conference presentations in mathematical biology, quantitative pharmacology, or QSP Knowledge of pharmacokinetics (PK), pharmacokinetic-pharmacodynamic (PKPD) modeling, QSP, population pharmacokinetics (pop PK), or graduate coursework in applied mathematics is desirable but not required Knowledge of modeling softwares commonly used in the pharmaceutical industry such as Phoenix WinNonlin, SimBiology, SimCyp, or MonolixSuite is desirable but not required Expertise in at least one specific disease area is desirable but not required Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization. You must be enrolled in an advanced degree program if graduating before August 2026 You must be available to work full-time, 40 hours per week from May - August 2026 Program Details: Full-time, paid internship $26.00 - 35.00 USD/hour Program Dates: May - August 2026 At Vertex, we believe that when you feel your best, you can perform at your best. That's why our US benefits and global well-being resources are designed to support you. • Free 24/7 onsite gym access and free access to group exercise classes • Subsidized commuter benefits- transit and parking • Provided meals-free breakfast daily! • Career development opportunities and events, including C Suite engagement • Social events-both intern-only and company-wide • Location-specific perks and extras! • Recognition of National Intern Day Equal Opportunities Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Vertex is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. Accessibility & Accommodations We're focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Vertex is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com. Export Control Notice This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant's ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role, Vertex is unable to sponsor non-U.S. persons to apply for an export control license. This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer. For any questions or concerns, please contact early_***************. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Are you a strategically focussed Regulatory professional and would like to play an integral part in bringing life changing Oncology medicines to patients? If you are please read on! At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person. Oncology Regulatory Science and Strategy Within Oncology Regulatory Science and Strategy (ORSS) we bring hope and solutions to patients with unmet needs across the globe. As Regulatory professionals working on Oncology products, we work in areas of unmet need and take innovative regulatory approaches to bring life-changing treatments to patients. We work across our pipeline and the business to get medicines to patients as efficiently and effectively as possible. The Senior Regulatory Affairs Director (SRAD) serves as the Franchise Global Regulatory Lead (GRL) developing and implementing the global strategy on complex oncology programs with multiple indications. In addition, the SRAD has the ability to function in dual capacity by serving as the regional lead based on location. The SRAD establishes external relationships with key stakeholders, leveraging these to maintain competitive advantage. You will be viewed as a senior leader within the Regulatory community. What you'll do Lead a Global Regulatory Strategy Team (GRST) of GRLs within the franchise, contributing members from the regions, emerging markets, RA CMC, Labelling and members of the submission and execution team. Ensure that the strategy is crafted to deliver approval with competitive labelling in keeping with the properties of the product(s) and the needs identified by the business, markets and patients. Lead the assessment of emerging data against aspirations and update Leadership on project risks/mitigation activities. Represent Regulatory Affairs on Global Product Teams (GPTs) providing strategic advice and accountable for all regulatory activities. Own the delivery of all milestones on your team including assessment of the probability of regulatory success based on a detailed assessment of risks and mitigations. Demonstrate strategic leadership skills thereby contributing to effective product development. Promote novel regulatory initiatives internally and engage externally on the corresponding topics. Lead the development of novel tools and technology. Partner and influence developing views/guidance on a global scale. Education, Qualifications, Skills and Experience Essential for the role: An advanced degree in a science related field and/or other appropriate knowledge/experience. Previous demonstrated experience of regulatory drug development including product approval/launch. Successful leadership to at least one major regulatory approval at a global level including leading response team and labeling negotiations is desired. Previous experience in leading major health authority interactions. Solid knowledge of regulatory affairs within several therapeutic areas in early and late development. Broad background of experience working in pharmaceutical business and prior experience in several areas within regulatory affairs. Experience in relevant therapy area (small molecules & biologics) is preferred. Proven leadership experience. Ability to think strategically and critically and evaluate risks to regulatory activities. Deep understanding of global regulatory science and will integrate with project strategy. You have a long standing experience of overall drug/biologic development processes and strategies for high profile, complex or novel development programs. Desirable for the role: Experience in the development or application of radio-conjugates would be highly advantageous. Previous experience with FDA advisory committee and EMA oral explanation hearings would be a plus Previous experience working on due diligence activities and in a business alliance environment. Ability to work strategically within a complex, business critical and high-profile development program. Why AstraZeneca? At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare. So, what's next? Are you already imagining yourself joining our team? Good, because we can't wait to hear from you! Competitive salary and benefits package on offer: Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. The annual base salary for this position ranges from $211,581.60 - 317,372.40. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) or to receive a retirement contribution (hourly roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Date Posted 26-Nov-2025 Closing Date 30-Dec-2025 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you'll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We're passionate about innovation, inclusion, and supporting your growth-inside and outside the lab. Why Vertex? * Real Projects: You'll work on assignments that make a real impact, not just busy work. * Mentorship & Networking: Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career. * Flexible & Supportive: We offer flexible work options with Flex @ Vertex and prioritize your wellbeing. * Inclusive Culture: Collaboration and inclusion are embedded in everything we do. * Career Launchpad: Build skills, explore career paths, and get guidance for your future career. Ready to apply? Submit your application and let's turn possibilities into reality! Your Impact The Vertex Clinical and Quantitative Pharmacology internship program is a multi-week experiential training program for students currently working towards a Doctoral degree in pharmacology or PharmD, or a related field of study. If you are passionate, collaborative, and growth-minded, an internship at Vertex will help you gain meaningful experience in our research functional areas and serve as a launchpad for your career. Important Notice Regarding Internship and Co-op Inquiries At Vertex Pharmaceuticals, we are committed to providing a fair and structured recruitment process for all students interested in internship and co-op opportunities. To ensure consistency and equity, all student applications must go through our Early Talent Acquisition Team. Due to the high volume of interest, we are unable to respond to individual solicitation. Direct solicitation to Vertex employees- including senior leaders via email will result in removal from the recruiting process. We appreciate your enthusiasm and interest in Vertex. To be considered for internship or co-op roles, please apply directly through our official application channels. (************************************************************************** Thank you for respecting our process and helping us maintain a fair experience for all candidates. What you will be doing: The Clinical and Quantitative Pharmacology (CQP) department at Vertex leads clinical pharmacology and clinical modeling & simulation efforts across all disease areas and clinical phases of drug development. There will be two CQP summer internship positions available with the opportunity to work with experienced mentors within CQP. A Vertex CQP summer internship will provide a 12-week hands-on opportunity to experience some of the elements of CQP within drug development. Based on the project, an intern may participate in numerous activities, such as design and conduct of clinical pharmacology studies (e.g., first-in-human, drug interaction, food effect, special populations, ADME), or exploration of drug pharmacokinetic (PK) and pharmacokinetic/pharmacodynamic (PK/PD) relationships and related analyses (e.g. population PK or other advanced modeling). Activities the successful candidate may be involved in include literature research, drafting and reviewing clinical study protocols, reviewing clinical study report sections, creating analysis plans, learning to manipulate and create clinical analysis-ready datasets, build and evaluate models, execute analyses, and prepare informative outputs, graphics, and results representations. During the 12-week appointment, the summer intern will also be exposed to various aspects of the drug development process and thereby gain a view into how the CQP functions fit within broader cross-functional drug development teams that often include preclinical disciplines, clinical development, clinical operations, bioanalysis, biostatistics, and more. Not only will interns learn about their day-to-day responsibilities, but they will interact with scientists from various levels, and with organizational leaders and their teams through a series of Professional Development Workshops that are provided during the summer. Clinical and Quantitative pharmacology activities may include the following (project dependent): * Research literature, published studies, and regulatory guidance * Learn to work with and manipulate clinical data and data constructs * Analyses of data collected from literature or clinical trial PK and/or PK/PD data in NONMEM, R and/or related software * Summarize the main findings * Prepare presentation(s) for various internal forums What you will need to succeed: * Enrolled in a PhD or PharmD program in pharmacology, or a related field of study by Fall 2025. * Communicate clearly through verbal and written communication * Understanding of drug metabolism, PK, and PK/PD principles * Knowledge of protein therapeutics preferred * Quantitative and hands-on skills preferred: * PK and/or PK/PD analyses * Experience with data analysis tools such as R, Phoenix WinNonlin, NONMEM or other programming/software applications * Prior industry experience preferred but not required * Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization. * You must be available to work full-time, 40 hours per week from May - August 2026 Program Details: * Full-time, paid internship $33.00 - 50.00 USD/hour * Program Dates: May - August 2026 At Vertex, we believe that when you feel your best, you can perform at your best. That's why our US benefits and global well-being resources are designed to support you. * Free 24/7 onsite gym access and free access to group exercise classes * Subsidized commuter benefits- transit and parking * Provided meals-free breakfast daily! * Career development opportunities and events, including C Suite engagement * Social events-both intern-only and company-wide * Location-specific perks and extras! * Recognition of National Intern Day Equal Opportunities Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Vertex is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. Accessibility & Accommodations We're focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Vertex is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com. Export Control Notice This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant's ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role, Vertex is unable to sponsor non-U.S. persons to apply for an export control license. This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer. For any questions or concerns, please contact early_***************. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Employer: Vertex Pharmaceuticals Incorporated JOB TITLE: Principal Research Associate, Bioanalytical OPENINGS: 1 Conduct bioanalytical assays to support preclinical study sample analysis. Carry out method development and optimization to quantify target proteins. Maintain proper documentation of experiments and support QC data review. Collaborate with cross-functional teams to review study design and interpret results. Prepare technical reports and presentations to document and communicate results. REQUIREMENTS: Employer will accept a Master's degree or equivalent, in applied science, biotechnology or a related field and 3 years of experience in the job offered or in a Principal Research Associate, Bioanalytical-related occupation. Position requires demonstrable experience in the following: Perform biochemical and ligand binding assays to support sample analysis from preclinical studies including protein extraction and quantification, automated capillary western blot, ELISA, MSD and ELISPOT. Drive splenocyte isolation and cell culture. Coordinate sample storage, data analysis and interpretation using GraphPad PRISM. Perform assay development, optimization, and qualification according to FDA guidelines for bioanalytical method validation. Execute and document assays ELN with good laboratory practices and good documentation practices. Coordinate biodistribution, toxicology and pharmacology studies for investigational new drug application. Conduct biochemistry and molecular biology on CRISPR strategies for gene and cell therapies. Perform statistical analysis including 4PL, regression analysis, standard deviation and coefficients of variation calculations. Rate of Pay: $86500.00 - $129800.00 CONTACT: Send Resume to *********************. Reference 12140.705. EOE. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

The Director, Order Management Operations- Heme develops and provides strategic direction and leads daily operations of the US care management team supporting the US, Heme Business Unit. This individual will represent the US on the global cross-functional manufacturing team, developing slot allocation policies, managing exceptions processes, and managing system/manufacturing capacity. This individual will also play a key role in ensuring exceptional support is provided to our customers by our care manger team. This critical role will be highly cross functional within Vertex with the goal of providing industry-leading patient support through patient facing interactions and logistical coordination. Exceptional leadership and collaboration skills, as well as a strategic mindset are essential to the role. Strong partnerships will be required with internal functions such as finance, supply chain, manufacturing, IT, and other commercial colleagues. This individual will report to the Head of US Heme Patient Support. Key Responsibilities: Lead daily operations and overall performance of the Care Manager team in supporting the successful navigation of the Casgevy treatment journey: * Provision of real-time, high-quality, and individualized support to care managers * Clear and consistent communication of roles, responsibilities, and performance expectations * Daily monitoring to ensure consistent execution of all program requirements * First level of escalation for team members to gain resolution of issues or questions that arise relating to a Casgevy order and Vertex Connects programing * Consistent refinement and development of the CM role to ensure provision of impactful support in the logistical coordination of support activities and customer relationship development * Build/enhance and manage reporting to provide insights, trends and issues and drive CM performance * Collaborate with Heme leadership, the PECO Order Management Operations Director, the Patient Support Operations Associate Director, and the training team to identify performance trends and training opportunities * Ensure professional development of the CM team and the upskilling and refinement of the department's daily operations. * Support the roll out of new PSP/OM initiatives and processes to the CM team and provide daily monitoring and reinforcement and coaching to support adoption * Manage team insight generation and dissemination to ensure high quality and compliant daily team activities * Cultivate and maintain a positive and psychologically safe team culture Support Heme US Order Management daily operations including: * Responsible for the implementation of all new global and US OM initiatives (e.g. manufacturing, systems); ensuring new policies are aligned with US business objective * Support US OM strategy and process optimization to ensure the processes support global OM goals and the best possible customer experience including but not limited to: * System requirements (VCP and BEACON) * Ways of working with internal teams * OM communications * SOP/WI Documentation * Oversight and optimization of CM OM roles and responsibilities * EHR and portal system requirements (VCP and BEACON) * Cross functional ways of working with internal teams to support a complaint and cross functional approach to ATC support * Ensure timely and consistent program execution of OM Escalation, Quality Event, & Rapid Response support, lead any efforts around authoring external communications regarding specific batches and the integration of learnings into program operations * Provide oversight and serve as a point of escalation to remove barriers in the provision of support for all active US Casgevy orders * Maintain all SOP/WI documentation to ensure it accurately reflects the work being asked of the team * Serve as the OM cross functional partner with Vertex commercial supply chain & manufacturing team [CMSC], logistics, AIS, GTAM, and all additional supporting functions such as finance and IT for order management. * Collaborate with Heme leadership, the training team to identify performance trends and training opportunities. * Actively support the development of a positive team culture through behavior and initiatives. Qualifications: * Bachelor's Degree * Strong customer service focus and the ability to act with urgency to respond to customer needs * CGT experience preferred * Strategic mindset * 5+ years' experience as impactful people-leader preferably in the biotech/pharma environment * Excellent communication, interpersonal, and leadership skills * Ability to act with urgency to ensure time-critical activities are completed while ensuring all stakeholders are on-board and have clarity around the goals and objectives * Business savviness and ability to streamline processes and find opportunities for improvement * Must be able to effectively work in a fast-paced environment, with strong time-management skills * Some travel may be required to interact with customers and industry events and conferences * 10+ year's work experience in the biotech/pharma environment * Excellent communication, interpersonal, and leadership skills * Ability to act with urgency to ensure time-critical activities are completed while ensuring all stakeholders are on-board and have clarity around the goals and objectives * Ability to take complex situations and break them down into simple parts to enable stakeholders to make decisions / take actions * Business savviness and ability to streamline processes and find opportunities for improvement * Must be able to effectively work in a fast-paced environment, with strong time-management skills * Some travel may be required to interact with Authorized Treatment Center representatives Pay Range: $187,200 - $280,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you'll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We're passionate about innovation, inclusion, and supporting your growth-inside and outside the lab. Why Vertex? Real Projects: You'll work on assignments that make a real impact, not just busy work. Mentorship & Networking: Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career. Flexible & Supportive: We offer flexible work options with Flex @ Vertex and prioritize your wellbeing. Inclusive Culture: Collaboration and inclusion are embedded in everything we do. Career Launchpad: Build skills, explore career paths, and get guidance for your future career. Ready to apply? Submit your application and let's turn possibilities into reality! Your Impact The Vertex Formulation Development Small Molecule internship program is a multi-week experiential training program for students currently working towards a Doctorate degree in an Engineering or Science field (Pharmaceutical Science, Chemical Engineering, Chemistry), or a related field of study. If you are passionate, collaborative, and growth-minded, an internship at Vertex will help you gain meaningful experience in our formulation functional areas and serve as a launchpad for your career. Important Notice Regarding Internship and Co-op Inquiries At Vertex Pharmaceuticals, we are committed to providing a fair and structured recruitment process for all students interested in internship and co-op opportunities. To ensure consistency and equity, all student applications must go through our Early Talent Acquisition Team. Due to the high volume of interest, we are unable to respond to individual solicitation. Direct solicitation to Vertex employees- including senior leaders via email will result in removal from the recruiting process. We appreciate your enthusiasm and interest in Vertex. To be considered for internship or co-op roles, please apply directly through our official application channels. (************************************************************************** Thank you for respecting our process and helping us maintain a fair experience for all candidates. What you will be doing: We are seeking a motivated summer intern to join our Formulation Development Department at Vertex in Boston, MA. The Formulation Development group focuses on developing small-molecule formulation and processes to bring transformative medicines to patients. The intern will work closely with formulation scientists to develop an in-process control container closure integrity method to determine the oxygen level in lyophilized drug products. The intern will develop a workflow to determine the oxygen ingress rate into vials, using laser headspace analysis. The intern will plan and execute experiments, analyze data, and present results to the team. This internship will also provide an opportunity to learn about parenteral drug development process. Review literature of Lyophilization theory / process, and equipment familiarization Review literature and understand the importance of container closure integrity for parenteral drug products Understand theory of FMS-Oxygen Headspace Analyzer and equipment familiarization Sample preparation by lyophilization of drug product filled at different N2 pressure, including positive controls Establish a model and workflow to determine the time required for oxygen ingress into the vials and establish a predictable detection limit Develop an in-process control container closure integrity method based on oxygen headspace for parenteral lyophilized drug product vials Participate in group discussion and present project updates, including a final project summary to the broader department at the end of the internship What you will need to succeed: Must be currently enrolled in a PhD program in engineering/science field (Pharmaceutical Science, Chemical engineering, Chemistry or similar). Minimum GPA of 3.2 Excellent written and oral communication skills with the ability to think critically. Strong math skills particularly as applied to material/energy balances, and intermediate applied statistical analysis Ability to work effectively and comfortably in a multi-disciplinary team under defined timelines Hands-on experience in parenteral formulation development techniques Hands on experience in lyophilization is a plus Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization. You must be enrolled in an advanced degree program if graduating before August 2026 You must be available to work full-time, 40 hours per week from May - August 2026 Program Details: Full-time, paid internship $20.00 - 32.00 USD/hour Program Dates: May - August 2026 At Vertex, we believe that when you feel your best, you can perform at your best. That's why our US benefits and global well-being resources are designed to support you. • Free 24/7 onsite gym access and free access to group exercise classes • Subsidized commuter benefits- transit and parking • Provided meals-free breakfast daily! • Career development opportunities and events, including C Suite engagement • Social events-both intern-only and company-wide • Location-specific perks and extras! • Recognition of National Intern Day Equal Opportunities Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Vertex is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. Accessibility & Accommodations We're focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Vertex is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com. Export Control Notice This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant's ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role, Vertex is unable to sponsor non-U.S. persons to apply for an export control license. This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer. For any questions or concerns, please contact early_***************. Pay Range: $0 - $0 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Job Posting: Vertex Fellows ProgramLocation: Boston, MAFlex Designation: On-Site DesignatedStart Date: August/September 2026Application Deadline: January 9, 2026, by 5:00 PM ETPlease submit a CV/resume and cover letter with your application. Letters of Recommendation will be requested if invited to interview. About the ProgramThe Vertex Fellowship is a unique, one-year training program for outstanding scientists and physicians passionate about solving unmet medical needs and advancing transformative science. Fellows join Vertex for a customized post-doctoral experience, gaining hands-on experience with real-world R&D challenges and benefiting from mentorship by Vertex leaders.This program is designed to provide participants with a broad understanding of the science and business of drug discovery.Program Highlights Project-based Fellowship: Embed for one year within a Vertex project team Work on a project of relevance, based on your skills and our pipeline needs Training & Mentorship Intensive didactic training on the science and business of drug development Scientific mentorship from research leaders Career mentorship from Vertex leaders Exploring Career Fit Upon completion, participants will be able to effectively decide if a career in industry is the right fit, and if so, how they might develop their career Why be a Vertex Fellow? Contribute to transformative medicines: Help patients by advancing scientific ideas in a team-based environment Accelerate your career: Learn about drug discovery and build your professional network Mentorship: Receive guidance from scientific, medical, and business leaders at Vertex Vertex Fellows Network: Develop connections internally and externally Program Timeline Applications Accepted: November 24, 2025 - January 9, 2026, by 5:00 PM ET Interview Invitations: February 2026 (Letters of Recommendation requested at this time) Interviews: Early March 2026 Formal Offers: Mid-late March 2026 Program Start: September 2026 Program End: August 2027 Eligibility Requirements PhD, MD, or joint degree attained within 0-5 years Demonstrated scientific impact (e.g., peer-reviewed publications, presentations, awards) Evidence of creative thinking, scientific problem solving, and innovation Interest in learning how scientific research leads to the development of therapies Application InstructionsPlease submit your CV/resume and cover letter by January 9, 2026, 5:00 PM ET.In your cover letter, consider addressing: Your most significant scientific or research achievement and how you accomplished it An example of how you applied creative thinking to solve a problem What you hope to gain from the Vertex Fellows Program Letters of Recommendation will be requested if invited to interview. Pay Range: $110,000 - $165,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking an experienced commercial leader to implement field sales and non-personal promotion tactics in support of the North America Commercial (NAC) business. The Customer Strategy & Execution Lead (CSEL) will partner with North America commercial organization to implement the go-to-market (GTM) strategy and deliver customer solutions that meet the business needs. This role will lead a team of Associate Directors, Customer Strategy & Execution Leads and will work directly with the BU stakeholders, Field Operations Leads, Digital Operations Leads, Customer Data Management, and technical stakeholders to optimize HCP customer experience. This role reports to the Executive Director, North America Commercial Operations & Insight Analytics. Key Duties and Responsibilities: Lead a team of 3-4 Associate Directors, Customer Strategy & Execution Leads, each with specific business unit (BU) alignments In addition to leading the team, this role will have responsibility for the Cystic Fibrosis BU. In that capacity, partner with key business leaders to understand business strategy and translate to prioritized commercial operations needs to enable all customer-facing engagements Build and strengthen relationships with key leaders (heads of BU, Marketing, Field) - become a trusted partner and have an ongoing, significant impact towards meeting / exceeding strategic business goals Define and lead portfolio of projects of field enablement and marketing campaigns, ensuring quality and timeliness of delivery while remaining within allocated budget limits Co-develop HCP and patient customer journey maps across Field Operations and Digital Operations Conduct periodic after-action reviews to identify gaps and forward-looking opportunities in evolving technologies and potential business process improvements in pursuit of driving efficiencies and exceeding business goals Budget management / accountability- plan and manage financial resources for field enablement, field customer-facing activities, non-personal promotion Create and manage an integrated brand engagement playbook that enables cross-functional teams to have a singular source for key strategic and executional insights and plans (targeting, approved messages, engagement planning) Lead quarterly business planning sessions and document outcomes to ensure alignment across BU leaders on key upcoming priorities to prioritize work for key cross-functional enablement teams (e.g., DTE, DSS) Active participation in recurring BU Leadership Team Meetings to provide strategic recommendations to drive brand growth and proactively identify any risks or dependencies related to field and marketing engagement Qualifications 10-12 years' experience working in delivering customer-facing programs with at least 8-10 years of industry experience Experience in commercial launch readiness, supporting launch planning across multiple systems including CRM, Digital Customer Engagement, Reporting & Analytics, and Digital Marketing, etc. Able to translate broad business strategies and functional priorities into effective operational goals and objectives; able to actively participate in strategic planning for the function Results oriented leader with a proven track record of on-time project delivery for large, cross-functional, and complex projects with stakeholders Exceptional written and verbal communication skills and ability to present in a clear and concise manner to all audiences Exceptional analytical, quantitative, problem-solving, and prioritization skills, including the development of business cases/ value propositions Substantial program/ project management, demand management, resource management and system life cycle expertise Education and Experience Bachelor's degree required Advanced degree preferred Pay Range: $188,000 - $282,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Director State Government Affairs will be responsible for developing and implementing the company's state/regional government affairs and public policy strategy. This position will work closely with several functional areas, including patient advocacy, communications, policy, patient advocacy, medical affairs, and commercial, to lead the company's public policy efforts and advance our company's goals. Field-based position. Incumbent resides in the region (CA, AZ, NV, HI, AK) Key Responsibilities: • Developing, coordinating, and leading the company's state/regional public policy efforts; • Working collaboratively with communications, patient advocacy, policy, medical affairs, and marketing departments to ensure that state public policy goals are aligned to meet company objectives and most effectively serve the needs of patients; • Analyzing and monitoring legislation, regulations, and political activity relating to issues that may impact Vertex; Drives strategy and creates plans of actions to impact policy change; • Developing and maintaining high-level relationships with government officials, community leaders, advocacy groups, external organizations, and stakeholders to achieve Vertex goals; • Collaborating with and facilitating advocacy coalitions for specific public policy goals, including rare disease awareness and Vertex's commercial and pipeline disease area policy issues; • Leads complex cross-functional initiatives that have impact across the team • Developing as necessary written analyses, testimony and background materials in support of Vertex objectives; • Leveraging pre-existing relationships as well as facilitating partnerships with additional community-based organizations and coalitions to reach public policy and company goals; • In partnership with cross-functional partners, integrating Vertex's public relations objectives with the state/regional public policy strategy and identifying additional opportunities to increase rare disease awareness and disease burden awareness, especially around Vertex's commercial and pipeline disease areas; • Managing contract lobbyists and overseeing compliance with state laws for lobbyist registration, reporting and political contributions; • Identifying and pursuing additional opportunities to advance our company's business objectives; • Fulfilling other duties/projects as assigned; • Exemplifying Vertex's core values in fulfilling these job duties. • Field Travel required 40-50% (Incumbent resides in the region California preferred) Minimum Qualifications • Minimum of seven to ten years current and relevant experience in state government affairs, state government or at a major trade association with significant direct lobbying experience; • Demonstrated ability to build and sustain relationships with members of the legislature, administration and other government and community leaders; • Significant knowledge of state legislative and regulatory systems; • Demonstrated outstanding strategic planning, communication and presentation skills; • Bachelor's degree required (advanced degree preferred) in science, law, government or public policy; • Pharmaceutical or healthcare sector experience strongly preferred; • A high level of energy and passion toward patients, science and public health; • Proven teamwork and collaboration skills, with a demonstrated ability to interact and influence all levels of business; • Detail-oriented, self-initiating, well-organized and capable of managing multiple projects simultaneously and independently; • Demonstrated ability to think outside the box and develop innovative solutions; • Strong understanding of the legal and regulatory environment along with demonstrated integrity on the job; • A desire to work in the corporate culture of a highly innovative company aimed at redefining health and transforming lives with new medicines. #LI-NP1 Pay Range: $199,500 - $299,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

We are seeking a talented, self-motivated and collaborative in-vivo pharmacologist to join the integrated pharmacology team supporting late-stage drug discovery. The ideal candidate will have a strong foundation in pharmacology, work with a high degree of independence and be adept at conceptually designing, executing and interpreting in vivo/ex vivo experiments to establish therapeutic proof-of-concept across diverse disease areas. Key Duties and Responsibilities: Designs and conducts elaborate, conceptually connected, multi-component in vivo/ex vivo experiments to demonstrate proof-of-concept in preclinical disease models including pharmacokinetic, pharmacodynamic and efficacy relationships. Perform advanced and/or complex experimental assay development and troubleshooting. Collates and interprets complex data systematically and synthesizes results into a cohesive body of conclusions or recommendations to guide Project decisions and new research activities. Exercises solid judgment to prioritize studies, considering feasibility and Project impact. Scours relevant scientific literature and routinely incorporates new insights into research activities. Identifies, prioritizes and introduces relevant emerging technologies in their field of expertise to advance the existing technology platforms and create/maintain a competitive advantage. Explores the feasibility of applying new scientific principles/concepts or implements and validates novel experimental approaches and technologies to achieve project goals. Contributes significantly to patent and/or publication preparation. Independently prepares study presentations and presents experimental conclusions at internal Group/Department or Project Team research meetings. Performs other duties as assigned. Knowledge and Skills: Designs and executes complex, well controlled, challenging experiments that measure the action of compounds on in vivo/ex vivo disease biology assays. Maintains a broad working knowledge of fundamental pharmacology principles. Demonstrates astute understanding of his/her own discipline and the relevant literature. Maintains a high level of knowledge related to current developments in the scientific Project field. Displays proven productivity and experimental creativity, and effective dissemination of ideas. Demonstrates effective, self-sufficient communication skills, especially in peer-directed presentations. Demonstrates awareness of other Project-related disciplines and an understanding of general concepts and some experimental detail within those areas. Must be proficient in rodent handling, dosing (IV, PO, IP, SC), blood collection (tail nick, submandibular, cardiac puncture) and tissue harvesting. Demonstrate experience developing, executing and troubleshooting assays across a wide array of in vivo and molecular techniques (i.e. ELISA, qPCR, Western and flow cytometry). Ability to rapidly learn and master new techniques and technologies. Essential qualities include: integrity, flexibility, adaptability, organization and multi-tasking skills, excellent record keeping and the ability to function both independently and effectively as part of an interactive and cross-functional team. Education and Experience: Bachelor's degree in pharmacology or related biological sciences Typically requires a PhD and 0-3 years of experience or, Typically requires a Masters degree and 3 years of experience or, Typically requires a Bachelors degree and 6 years of experience #LI-KM4 #LI-Onsite Pay Range: $105,600 - $158,400 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is a global biotechnology company that invests in scientific innovation. The Digital, Technology and Engineering (DTE) Research, Pre-Clinical, Manufacturing & Supply (RPMS) Group's mission is to improve the lives of patients through data, and technology innovation - with AI at the core of our transformation strategy. Vertex is in a transformational period where we are accelerating our capabilities, technology and data to augment our mission and enable Vertex to grow in scale; ensuring we remain on the forefront of science, medicine and technology. The Senior Director, Supply Chain Data & Technology will define, lead and execute the vision for how Vertex will revolutionize our global Supply Chain through AI, data science and technology solutions. You will champion the adoption of AI-driven approaches to optimize supply chain operations, drive predictive analytics, enable intelligent automation across clinical and commercial supply based upon a foundation of robust transactional systems to plan, track and action supply chain activities. Working with multiple Vertex business units, the Senior Director is accountable for the end-to-end Supply Chain experience worldwide, across a broad range of internal and external teams, partner companies and operating models, powering both clinical and commercial supply. The role is a critical part of the Data Technology & Engineering leadership community. The Senior Director will bring their multi-disciplinary expertise to orchestrate innovation with leaders across Supply Chain, finance, legal, data science and technology, including core disciplines in infrastructure, data and software engineering, data science, architecture, portfolio and security, to ensure coordinated transformation through smart, scalable solutions. Reporting directly to the VP RPMS, the dynamic and experienced Senior Director, Supply Chain Data & Technology will play a key role on the RPMS Leadership Team to drive our digital transformation initiatives across Research, Pre-clinical, Manufacturing and Supply Chain. Key Duties and Responsibilities Vision and Strategy Develops, articulates, and executes a clear vision for delivering AI-powered technology solutions for Supply Chain worldwide, internally and externally, across multiple business units, in alignment with Vertex's strategic goals. Influences a broad internal and external landscape to cultivate a roadmap of opportunities to transform supply chain activities through cutting-edge AI technologies including generative and agentic AI, machine learning and data driven automation. Leads with agility to think strategically about planning, logistics, trade, business, product, and technical challenges simultaneously. Collaborates as a trusted partner to Supply Chain leadership to ensure technology strategies robustly accelerate portfolio and commercial goals and as key enablers of operational excellence. Operational Execution Specializes in driving transformative strategies that foster innovation, elevate organizational performance and drive growth. Leads in the identification of opportunities for innovation in delivery, evaluation of state-of-the-art AI (including generative AI and agentic AI), data product, data science, external and internal integrations, software, hardware and protocols, applicability and risks. Combines creativity, practicality and integrity to ensure technology solutions that are strategic, flexible, scalable, reusable and are achieved through the application of Vertex's architectural principles, standards and governance. Leads with rigor and discipline maximizing fiscal, resource and operational effectiveness. Manages an effective and efficient technology operation that enhances Supply Chain at Vertex, ensuring stakeholders can depend on technology as a robust enabler of drug research and production whilst maximizing ROI. Partners effectively with suppliers ensuring effective delivery aligned to Vertex's high expectations in compliance, quality and security. Leadership Leads and develops a high-performing, diverse team of professionals, fostering a culture of innovation, collaboration, and accountability. Creates a culture of inclusion, diversity, and equity where everyone can do their best work and feels valued. Aligns the Supply Chain technology team with enterprise priorities, ensuring data strategies drive business outcomes and regulatory compliance. Represent the Supply Chain technology organization in internal and external forums, advocating for its ability to achieve strategic goals and for innovation leadership. Required Education and Experience Bachelor's degree in science, engineering, computer science or a related field 10+ years of experience in life sciences technology or related fields. Relevant experience in creating and applying technologies to solve computationally intensive and data intensive problems in Supply Chain, inclusive of 5+ years in a leadership role. Required Knowledge and Skills Extensive knowledge of global Supply Chain environments to effectively understand user needs. Extensive technical knowledge and experience across broad range of complex Supply Chain technology. Extensive experience in applying AI and machine learning to solve complex, data intensive problems in global Supply Chain environments. Experience with varied compute environments including distributed, cloud and high performance computing. Experience of successfully developing and implementing technology strategy; preferably within a complex pharmaceutical Supply Chain organization. Expertise in successful development and delivery of multiple complex technology development initiatives. Strong leadership and team-building skills, with demonstrated success in managing diverse teams and fostering high engagement. Excellent communication skills including the ability to produce strategic documents, present ideas and solutions to technical and non-technical audiences and all levels of the organization. A strong commitment to compliance and integrity in systems, processes, and actions, with a deep understanding of the biotech regulatory environment. Exceptional problem-solving and strategic thinking abilities, with a focus on driving innovation and operational excellence. Other Requirements Experience with enabling advanced technologies, such as AI and machine learning, through data engineering strategies is highly desirable. Advanced certifications in product, agile, software engineering, cloud technologies, or leadership. #LI-hybrid Pay Range: $236,000 - $354,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

At AstraZeneca, we turn ideas into life-changing medicines. Working here means thinking big and working together to make the impossible a reality. We're focused on the potential of science to address the unmet needs of patients around the world. We commit to those areas where we think we can really change the course of medicine and bring big new ideas to life. At AstraZeneca, we are taking bold action on climate because we recognize the connection between healthy people and a healthy planet. As part of our flagship Ambition Zero Carbon program, we have committed to a fully electric vehicle (EV) fleet by the end of 2025, which means that all our drivers will be assigned an EV. As a Senior Pharmaceutical Sales Specialist for the Specialty Care Team, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. Accountabilities - Develop and demonstrate strong knowledge of clinical disease states and treatment guidelines. - Effectively communicate product information to healthcare professionals to influence prescribing behavior. - Execute call plans and Brand Strategy by translating data to actionable insights. - Build and maintain working relationships with healthcare professionals. - Drive portfolio demand performance through meaningful customer interactions leveraging multiple channels, such as digital platforms and face-to-face engagements to reach the customers. - Demonstrate openness to new ideas and seek innovative approaches to sales and customer engagement. Essential Skills/Experience - Bachelor's Degree - 2+ yrs of demonstrated Sales or Commercial experience or a combination of: pharmaceutical, healthcare, scientific, clinical, institutional or related industry experience - A valid driver's license and safe driving record Essential Skills and Capabilities - Customer Engagement: Demonstrated commitment to improving patient outcomes through effective engagement with healthcare professionals. - Advanced Sales Techniques: Experience with advanced sales techniques and strategies tailored to specialty care markets. - Clinical Acumen: Strong understanding of clinical trial data and the ability to communicate complex scientific information clearly. - Business Acumen: Ability to conduct detailed market analysis and leverage insights for strategic planning. Desirable Skills/Experience - Therapeutic area experience, specialization in clinical setting, and sales experience At AstraZeneca, we are on a journey to bring life-saving medicines to patients. Our role in contributing to decreasing mortality rates globally is clear. We shape the future by spotting scientifically led commercial opportunities and acting now to operationalize and scale them. Driven by the solutions we bring to the healthcare ecosystem, we make an impact at every step of the patient journey, improving their experience and outcomes. Our inclusive team draws on diverse backgrounds, skills, and experiences to create innovative solutions that make a difference. Join us in making a meaningful impact on patients' lives by applying today! The annual base salary (or hourly rate of compensation) for this position ranges from $107,172 -$160,758. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) or to receive a retirement contribution (hourly roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Date Posted 12-Dec-2025 Closing Date Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

The Director, Global Process Excellence, Finance Systems and Reporting is a key member of the Vertex Global Finance organization and will be leading continuous improvement workstreams including projects aimed at improvement of Global Finance processes, implementation and enhancement of finance systems and support of enterprise reporting capabilities. Reporting to the VP, Global Process Excellence, Finance Systems and Reporting, this role is a key leader in ensuring that Vertex's global R&D/BSMO finance teams can scale efficiently to meet the needs of an increasingly large and complex pipeline by optimizing global processes, implementing and enhancing finance systems and building new scalable global capabilities to enable efficient and effective enterprise planning and reporting. An important aspect of this role is the ability to have influence without authority, and to be able to maintain an enterprise-wide view where global processes and solutions are most effective and efficient for Vertex. Success in this role requires a deep understanding of Vertex's business and strategy including a strong understanding of R&D, BSMO and PPM processes, experience in designing and implementing global processes and finance systems, an ability to lead and manage change and to collaborate effectively within Finance and with other key stakeholders (Accounting, Internal Audit, DTE, PPM, HR etc.) to ensure strategic and operational alignment. Collaboration and strong partnership with R&D Finance, BSMO Finance (including cost accounting) and the PPM organization is paramount to success in this role. In addition, success will include an ability to lead and support process improvement projects. This includes partnering with project owners to plan and execute workshops, as well as help to create documentation where needed, and project manage follow ups and implementation when needed. Finally, this role will help develop continuous improvement skills within our global finance team, providing coaching, sharing tools and promulgating best practices. Key Duties & Responsibilities Strategizes with finance and business leaders to identify and prioritize global R&D Finance process optimization opportunities to enable Vertex's efficient growth through industry-leading cross-functional innovation and business partnering. Partners with Finance leadership to develop a strategy for that organization's efficient scaling on short term processes as well as the LRP. Leads process and systems enhancement workstreams to help optimize the use of data driven insights to drive integrated enterprise decision making. Enables VRTX growth by using data and technology platforms to enable operating efficiencies, growth and ability to scale with sustainable, compliant and risk balanced processes. Drives implementation of VRTX global financial data structures to ensure that we are organizing and governing data to enable effective performance management and decision support as Vertex grows in scale and complexity. Partners closely with Finance, PPM, HR, Accounting and DTE to ensure that Vertex is building integrated enterprise planning capabilities to enable short- and long-term decision making and resource allocation. Collaborates and communicates effectively with others, identifies opportunities where change management is needed and helps to develop plans of action to address the gaps. Helps to develop and coach more junior team members to encourage growth and new opportunities and maintaining an atmosphere of inclusivity across the team. Utilizes data analytics and metrics to identify trends, make recommendations and mitigate resourcing and financial risks. Basic Requirements: Bachelor's degree in business, Finance or Accounting. MBA and CPA a plus. Typically requires 12+ years of relevant experience in a finance managerial role demonstrating strong technical and analytical skills, and a track record of success working in a team-based environment or the equivalent combination of education and experience. Preferred Knowledge/Skills: Possesses a continuous improvement mindset, constantly interrogating the way we operate with flexibility and ability to drive change. Significant experience leveraging Lean and Six Sigma concepts to identify opportunities for improvement and to develop and implement action plans. Experience partnering with cross-functional teams and processes; able to manage through ambiguity and influence with and without authority. Must have vision for the future, an ability to think strategically on getting alignment across various groups, and an ability to partner effectively with R&D and BSMO Finance leadership. Ability to find innovative solutions to complex problems, leveraging industry best practices and finding solutions that are fit-for-purpose for Vertex but also contemplate future business needs. Ability to effectively work with and influence senior leaders including the DTE LT, FLT, HR LT and PPM LT individually and in gaining alignment amongst these groups when needed. Strong interpersonal, written, and verbal communication skills. Significant knowledge of drug development process with strong business acumen and judgment; knowledge of the company's markets/products a plus. Strong project management ability and ability to manage multiple projects and areas of ownership. Proactive, organized, and comfortable managing shifting priorities in a rapidly changing environment. #LI-DB1 #HYBRID Pay Range: $180,800 - $271,100 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Vertex is seeking a talented and experienced leader to join our Analytical Development Team to lead Biologic project CMC analytical development activities. The experienced leader will play a central role in advancing our biologics projects by executing development activities through a combined internal and external network. The individual is expected to closely work with external partners in developing and executing the development activities of biologics from the discovery interface to first license approval and beyond. The individual is expected to lead the execution of analytical activities according to phase appropriate development strategies. The successful candidate must work well in a fast-paced, integrated team environment. Strong experience in managing external CRO/CTO is a must. The individual is expected to drive effectively with external partners in the execution of analytical development activities for multiple programs. The candidate must demonstrate strong communication skills, technical expertise in state-of art analytical methodologies and problem-solving skills. Strong technical background is desired in the area of analytical techniques commonly used in the analysis of biologics products, along with data analysis and statistics used in product specification setting. The candidate is expected to collaborate closely with the Research, Process Development, Manufacturing, Quality, Regulatory functions to develop and deliver products to the clinical. The ability to work in a matrix team environment is essential. As a member of dynamic and diverse Analytical Development and CMC teams focused on science and innovation, this position will provide opportunities for continued learning and cross-functional collaboration enabling the individual to grow broadly beyond one's own discipline as a scientific and technical leader. Key Duties and Responsibilities: Leads an analytical matrix team in execution of biologics analytical development Partnering with internal and external labs in executing analytical development activities, including designing, planning, and executing all analytical activities that lead to successful IND/IMPD and/or BLA/MAA applications. Authors CMC sections of regulatory submissions. Ensures that all regulated work and documents conform to GMP standards Proactive resource planning to align with established development strategy Maintain a strong internal and external network for the execution of analytical activities Knowledge and Skills: Excellent communication skills and interpersonal skills with the ability to build strong cross-functional relationships and communicate complex issues and concepts Track-record in leading cross-functional matrix team Excellent problem-solving skills in biologics development Deep technical understanding of analytical methodologies, such as LC, iCE, CE-SDS, ELISA, PCR, particulates etc. Deep technical expertise to lead analytical method validation and analytical transfer, establish analytical control strategy, design stability programs and comparability studies. Experience authoring CMC sections of regulatory documents. Experience of Regulatory guidelines relevant to biologics development Knowledge of cGMP requirements A strategic thinker with a strong result orientation and a sense of urgency to deliver quality results on time and in a highly ethical and professional manner The ability to work in a dynamic, fast pace, matrix environment, manage priorities and maintain timelines for multiple projects. Education and Experience: 6-8+ years (PhD) or 9+ years (MS) in relevant discipline (analytical, biochemistry, molecular biology, biotechnology or related field) with progressive experience in technical leadership roles in the biotech industry, and specifically in the development of analytical control strategies. Experience with Biological products CMC development is critical. Pay Range: $158,800 - $238,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com