Karyopharm Leadership

My passion is in the discovery and development of new drugs. I believe this is one of the most difficult, yet rewarding challenges. Senior executive with extensive experience in drug discovery and development. In last few years had the opportunity to participate in founding a small biotech (Epix/Predix) and co-leading it from early stage discovery to a publicly traded multi-product company, with three drugs in phase II clinical trials and two large pharmaceutical company partnerships. I managed preclinical teams and developed a discovery platform resulting in eight oral, small molecule clinical candidates. I've gain a lot of experienced in the preclinical and clinical development of CNS, cardiovascular and inflammation drugs.

Dr. Kauffman co-founded Karyopharm with Dr. Sharon Shacham in 2008 and served as our Chief Executive Officer from January 2011 to April 2021, as Chief Medical Officer from December 2012 to April 2021, and as a director since 2008. He is currently a Senior Clinical Advisor to the Company helping to guide additional clinical development for Karyopharm’s robust pipeline of programs, with an increasing focus on solid tumor indications.

Prior to joining Karyopharm, Dr. Kauffman served as Chief Medical Officer at Onyx Pharmaceuticals Inc., which acquired Proteolix Inc. in November 2009 where he was Chief Medical Officer and where he led the development of Kyprolis® (carfilzomib), a novel proteasome inhibitor which was approved by the FDA for the treatment of refractory myeloma in 2012.

Prior to joining Onyx, Dr. Kauffman was an operating partner at Bessemer Venture Partners where he led investments in biotechnology companies. Prior to that, he served as President and Chief Executive Officer at Epix Pharmaceuticals, Inc. and President and Chief Executive Officer of Predix Pharmaceuticals, Inc. Dr. Kauffman led the merger of Predix Pharmaceuticals and Epix Pharmaceuticals in 2006, oversaw the discovery and development of four new clinical candidates, and led collaboration transactions with Amgen and GlaxoSmithKline.

From 2000 to 2002, Dr. Kauffman was Vice President, Clinical at Millennium Pharmaceuticals, Inc., where he led the Velcade® (bortezomib) development program. From 1997 to 2000, Dr. Kauffman served in senior leadership roles at Millennium Predictive Medicine, Inc., a subsidiary of Millennium Pharmaceuticals, where he led the discovery and development of novel molecular diagnostics for major cancers and led transactions with Becton-Dickenson and Bristol Myers Squibb. From 1995 to 1997, he held a number of senior positions at Biogen Idec, Inc., where he led the clinical development of anti-D40L antibodies in autoimmune and inflammatory diseases, and acted as the main medical advisor to the Biogen business development group. Dr. Kauffman currently serves on the board of directors of Infinity Pharmaceuticals, Inc., Kezar Life Sciences, Inc. and Verastem Inc., which are all public biopharmaceutical companies.

Dr. Kauffman received his Bachelor of Arts in Biochemistry from Amherst College, his Doctor of Medicine and Doctor of Philosophy from Johns Hopkins Medical School, and trained in internal medicine and rheumatology at Beth Israel (now Beth Israel Deaconness Medical Center) and Massachusetts General Hospitals. He is board certified in internal medicine.

Mr. Paulson was appointed President and Chief Executive Officer of Karyopharm in May 2021 and has served as a member of Karyopharm’s Board of Directors since February 2020. He was previously an Executive Vice President of Ipsen Pharmaceuticals, Inc. and Chief Executive Officer of Ipsen North America, a global biopharmaceutical company focused on innovation and specialty care in areas of oncology, neuroscience and rare diseases, from February 2018 to May 2021. Mr. Paulson previously worked at Amgen for 10 years holding varying leadership positions across Europe and North America, including Vice President and General Manager of Amgen’s U.S. Oncology Business Unit, and prior to that served as the Vice President of Marketing for Amgen’s U.S. Oncology Business, General Manager of Amgen Germany, and General Manager of Amgen Central & Eastern Europe. Prior to Amgen, Mr. Paulson held a number of global leadership positions at Pfizer Inc., including serving as General Manager of Pfizer South Africa and Pfizer Czech Republic. Mr. Paulson also previously held a variety of sales, marketing, and market access roles with increasing seniority at GlaxoWellcome in Canada.

Mr. Paulson has an MBA from the University of Toronto, Canada and an undergraduate degree in commerce from the University of Saskatchewan, Canada.

Mike joined Karyopharm in February 2019 and is responsible for leading and directing the financial activities of the Company. He has over 18 years of diversified financial experience in executing financial strategies and leading growth initiatives for life sciences companies. He has deep expertise in global financial operations and controls, financing transactions, business planning and supporting pharmaceutical product launches.

Prior to joining Karyopharm, Mike spent over 13 years at Alnylam Pharmaceuticals, Inc. in a progression of finance roles. Most recently, he served as Vice President of Finance and Treasurer at Alnylam. Earlier in his career, Mike served as the Corporate Controller at Praecis Pharmaceuticals and previously worked in the audit practice at KPMG LLP, a national audit, tax and advisory services firm.

Mike received a Bachelor of Business Administration from Stetson University and an MBA from Babson College. He is also a Certified Public Accountant.

Influential senior leader dedicated to aligning people enablement and corporate social responsibility with professional and personal success, growth, and development

Ran joined Karyopharm in October 2014. He manages Karyopharm Europe GmbH, a subsidiary of Karyopharm, which provides the necessary corporate structure to support Karyopharm’s expanded clinical and regulatory activities in Europe. As Chief Development Operations Officer, Ran is also responsible for the corporate global development operations across the entire portfolio. In this capacity, he also manages the clinical departments including Clinical Operations, Medical Writing, Data Management, and Data Analysis.

Ran has more than 20 years of experience in the international biopharmaceutical industry encompassing clinical, regulatory, business development and commercial operations activities. Prior to joining Karyopharm Europe GmbH, he held a number of senior management roles in Europe, Israel and the United States, most recently as Managing Director EMEA for Clinipace Worldwide, an international clinical research organization, where he was responsible for the overall management of the organization in Europe, the Middle East and Africa. Prior to joining Clinipace Worldwide, Ran established and managed the Israeli office of PFC Pharma Focus AG, which was acquired by Clinipace in 2011, and where he held the position of Managing Director at Actelion Pharmaceuticals with responsibility for all science and business affairs of the company in Israel.

A registered pharmacist, Ran serves on the advisory board of Musli Thyropeutics and holds a Bachelor of Science in Pharmacy from the Hebrew University of Jerusalem.

Dr. Mitchener built a 15-year career at Novartis Pharmaceuticals Corporation, most recently as Head of U.S. Oncology Strategy, Partnering and Operations. In this executive team role, he led all business development and collaborations for Novartis U.S. Oncology across academic, big data, pipeline, product and technology partnering initiatives. In addition, he had responsibility for Loss of Exclusivity (LoE), Companion Diagnostic (CDx) and Enterprise Operations for a $5 billion P&L. Dr. Mitchener has also led both commercial evaluations for successful global product acquisitions and BD&L activities for multiple products. In his commercial roles, Dr. Mitchener helped lead and transition assets in immunology, infectious diseases, oncology and rare diseases from research through commercialization. Previously, Dr. Mitchener was the Business Franchise Head at Novartis Oncology for Australia & New Zealand, managing 13 products, including 5 new launches. Dr. Mitchener was a Board Observer for COTA Healthcare, where he provided guidance on operations, strategy, and Series C financing on behalf of Novartis Oncology. Dr. Mitchener received his Doctor of Pharmacy degree from the University of North Carolina at Chapel Hill and conducted his Postdoctoral work at Rutgers University and Novartis Oncology.

My passion is in the discovery and development of new drugs. I believe this is one of the most difficult, yet rewarding challenges. Senior executive with extensive experience in drug discovery and development. In last few years had the opportunity to participate in founding a small biotech (Epix/Predix) and co-leading it from early stage discovery to a publicly traded multi-product company, with three drugs in phase II clinical trials and two large pharmaceutical company partnerships. I managed preclinical teams and developed a discovery platform resulting in eight oral, small molecule clinical candidates. I've gain a lot of experienced in the preclinical and clinical development of CNS, cardiovascular and inflammation drugs.

Dr. Kauffman co-founded Karyopharm with Dr. Sharon Shacham in 2008 and served as our Chief Executive Officer from January 2011 to April 2021, as Chief Medical Officer from December 2012 to April 2021, and as a director since 2008. He is currently a Senior Clinical Advisor to the Company helping to guide additional clinical development for Karyopharm’s robust pipeline of programs, with an increasing focus on solid tumor indications.

Prior to joining Karyopharm, Dr. Kauffman served as Chief Medical Officer at Onyx Pharmaceuticals Inc., which acquired Proteolix Inc. in November 2009 where he was Chief Medical Officer and where he led the development of Kyprolis® (carfilzomib), a novel proteasome inhibitor which was approved by the FDA for the treatment of refractory myeloma in 2012.

Prior to joining Onyx, Dr. Kauffman was an operating partner at Bessemer Venture Partners where he led investments in biotechnology companies. Prior to that, he served as President and Chief Executive Officer at Epix Pharmaceuticals, Inc. and President and Chief Executive Officer of Predix Pharmaceuticals, Inc. Dr. Kauffman led the merger of Predix Pharmaceuticals and Epix Pharmaceuticals in 2006, oversaw the discovery and development of four new clinical candidates, and led collaboration transactions with Amgen and GlaxoSmithKline.

From 2000 to 2002, Dr. Kauffman was Vice President, Clinical at Millennium Pharmaceuticals, Inc., where he led the Velcade® (bortezomib) development program. From 1997 to 2000, Dr. Kauffman served in senior leadership roles at Millennium Predictive Medicine, Inc., a subsidiary of Millennium Pharmaceuticals, where he led the discovery and development of novel molecular diagnostics for major cancers and led transactions with Becton-Dickenson and Bristol Myers Squibb. From 1995 to 1997, he held a number of senior positions at Biogen Idec, Inc., where he led the clinical development of anti-D40L antibodies in autoimmune and inflammatory diseases, and acted as the main medical advisor to the Biogen business development group. Dr. Kauffman currently serves on the board of directors of Infinity Pharmaceuticals, Inc., Kezar Life Sciences, Inc. and Verastem Inc., which are all public biopharmaceutical companies.

Dr. Kauffman received his Bachelor of Arts in Biochemistry from Amherst College, his Doctor of Medicine and Doctor of Philosophy from Johns Hopkins Medical School, and trained in internal medicine and rheumatology at Beth Israel (now Beth Israel Deaconness Medical Center) and Massachusetts General Hospitals. He is board certified in internal medicine.

My passion is in the discovery and development of new drugs. I believe this is one of the most difficult, yet rewarding challenges. Senior executive with extensive experience in drug discovery and development. In last few years had the opportunity to participate in founding a small biotech (Epix/Predix) and co-leading it from early stage discovery to a publicly traded multi-product company, with three drugs in phase II clinical trials and two large pharmaceutical company partnerships. I managed preclinical teams and developed a discovery platform resulting in eight oral, small molecule clinical candidates. I've gain a lot of experienced in the preclinical and clinical development of CNS, cardiovascular and inflammation drugs.

Dr. Kauffman co-founded Karyopharm with Dr. Sharon Shacham in 2008 and served as our Chief Executive Officer from January 2011 to April 2021, as Chief Medical Officer from December 2012 to April 2021, and as a director since 2008. He is currently a Senior Clinical Advisor to the Company helping to guide additional clinical development for Karyopharm’s robust pipeline of programs, with an increasing focus on solid tumor indications.

Prior to joining Karyopharm, Dr. Kauffman served as Chief Medical Officer at Onyx Pharmaceuticals Inc., which acquired Proteolix Inc. in November 2009 where he was Chief Medical Officer and where he led the development of Kyprolis® (carfilzomib), a novel proteasome inhibitor which was approved by the FDA for the treatment of refractory myeloma in 2012.

Prior to joining Onyx, Dr. Kauffman was an operating partner at Bessemer Venture Partners where he led investments in biotechnology companies. Prior to that, he served as President and Chief Executive Officer at Epix Pharmaceuticals, Inc. and President and Chief Executive Officer of Predix Pharmaceuticals, Inc. Dr. Kauffman led the merger of Predix Pharmaceuticals and Epix Pharmaceuticals in 2006, oversaw the discovery and development of four new clinical candidates, and led collaboration transactions with Amgen and GlaxoSmithKline.

From 2000 to 2002, Dr. Kauffman was Vice President, Clinical at Millennium Pharmaceuticals, Inc., where he led the Velcade® (bortezomib) development program. From 1997 to 2000, Dr. Kauffman served in senior leadership roles at Millennium Predictive Medicine, Inc., a subsidiary of Millennium Pharmaceuticals, where he led the discovery and development of novel molecular diagnostics for major cancers and led transactions with Becton-Dickenson and Bristol Myers Squibb. From 1995 to 1997, he held a number of senior positions at Biogen Idec, Inc., where he led the clinical development of anti-D40L antibodies in autoimmune and inflammatory diseases, and acted as the main medical advisor to the Biogen business development group. Dr. Kauffman currently serves on the board of directors of Infinity Pharmaceuticals, Inc., Kezar Life Sciences, Inc. and Verastem Inc., which are all public biopharmaceutical companies.

Dr. Kauffman received his Bachelor of Arts in Biochemistry from Amherst College, his Doctor of Medicine and Doctor of Philosophy from Johns Hopkins Medical School, and trained in internal medicine and rheumatology at Beth Israel (now Beth Israel Deaconness Medical Center) and Massachusetts General Hospitals. He is board certified in internal medicine.

Mr. Paulson was appointed President and Chief Executive Officer of Karyopharm in May 2021 and has served as a member of Karyopharm’s Board of Directors since February 2020. He was previously an Executive Vice President of Ipsen Pharmaceuticals, Inc. and Chief Executive Officer of Ipsen North America, a global biopharmaceutical company focused on innovation and specialty care in areas of oncology, neuroscience and rare diseases, from February 2018 to May 2021. Mr. Paulson previously worked at Amgen for 10 years holding varying leadership positions across Europe and North America, including Vice President and General Manager of Amgen’s U.S. Oncology Business Unit, and prior to that served as the Vice President of Marketing for Amgen’s U.S. Oncology Business, General Manager of Amgen Germany, and General Manager of Amgen Central & Eastern Europe. Prior to Amgen, Mr. Paulson held a number of global leadership positions at Pfizer Inc., including serving as General Manager of Pfizer South Africa and Pfizer Czech Republic. Mr. Paulson also previously held a variety of sales, marketing, and market access roles with increasing seniority at GlaxoWellcome in Canada.

Mr. Paulson has an MBA from the University of Toronto, Canada and an undergraduate degree in commerce from the University of Saskatchewan, Canada.