Karyopharm jobs - 247 jobs

Role Overview & Key Functions: If you want to do something that matters, this work matters. Patients drive our passion to pioneer novel cancer therapies. That's why we've built an environment centered around support, flexibility, and a shared mission. Creating and delivering medicine for cancer can only be done through focus, dedication, and heart. We hire exceptional people and trust each other to work in whatever way lets us, be us - whether that's onsite, from home, or anywhere in between. Our summer intern program, which will run from May 25th - Aug 7th, allows students to gain real world work experience in a high energy, collaborative work culture. A summer internship in Clinical Pharmacology at Karyopharm is an exciting opportunity to apply the knowledge you have gained in the field, think strategically, learn and evaluate new tools to advance decision-making. Karyopharm is seeking applications for a Clinical Pharmacology Summer internship. Responsibilities * Learn from scientific mentors to navigate the field of drug development, pharmacometrics and clinical pharmacology * Develop pharmacometrics models that characterize drug exposure and response (efficacy and safety) relationship * Develop approaches to assess and improve model identifiability and evaluate new tools for pharmacometrics analysis * Build code repository for data visualizations, projections and simulations * Collaborate with data scientists, clinical scientists to provide solutions Qualifications * MS or PhD in Clinical Pharmacology, Pharmacokinetics, Pharmacometrics, Engineering or other suitable post-graduate qualification * Candidate demonstrates a breadth of experience in the field of clinical pharmacology/pharmacometrics * Strong quantitative skills and expertise in population modeling, exposure response analysis * Exposure to tools such as Phoenix WinNonlin, R, Pumas, NONMEM etc. * Motivation to learn Candidate Profile & Requirements: * Must be able to complete the Karyopharm Internship Program 27 May - 08 Aug 2025 * Must have a minimum GPA of 3.0 * Must be highly organized and have the ability to work in independently and collaboratively as a team * Clear, concise verbal & written communication Pay for internships ranges from $22 to $30 per hour, depending on the student's academic level (e.g., Bachelor's, Master's) and year in school. Our Value Proposition: At Karyopharm, we live and demonstrate our ICARE values every day! Check out our Culture Video!

A global biotech company is seeking an Associate Director for Strategy and Operations in Boston. This role supports the US Market Access Leadership Team, driving strategic initiatives and operational execution. The ideal candidate will have over 8 years of experience, strong communication and collaboration skills, and a Bachelor's degree. The position offers a hybrid or on-site work model and competitive compensation ranging from $155,700 to $233,600 annually, with additional benefits such as educational support and paid time off. #J-18808-Ljbffr

A leading biotechnology company is seeking an experienced Computational Biologist to lead their Boston-based computational genomics team. This role requires advanced understanding in genomics and computational biology, with responsibilities including project leadership and design of genomic studies. Candidates should have a PhD, substantial industry experience, and strong communication skills. The position is hybrid-eligible, offering flexibility between onsite and remote work, with a competitive salary range of $172,000 to $258,000. #J-18808-Ljbffr

Senior Medical Science Liaison - Nephrology (Missouri/Iowa/Nebraska/ Illinois: South/Central) page is loaded## Senior Medical Science Liaison - Nephrology (Missouri/Iowa/Nebraska/ Illinois: South/Central)locations: Boston, MAtime type: Full timeposted on: Posted Todayjob requisition id: REQ-26673**Job Description****General Summary:**The Senior Medical Science Liaison (Sr MSL) (Nephrology) for Povetacicept programs. Povetacicept (pove) is an enhanced, dual BAFF/APRIL inhibitor in pivotal development for the treatment of IgA Nephropathy (IgAN).The Sr MSL will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights and contribute to the designing and execution of the Medical Affairs strategy and plan. The Sr MSL will engage HCPs in response to scientific educational and research needs with available Vertex resources and provide the latest emerging data in response to specific inquiries, as appropriate.**Key Duties and Responsibilities:*** Develops and fosters effective and trusting relationships with Thought Leaders (TL) and identifies and engages other appropriate HCPs resulting in scientific engagement with a large network of T1D and transplant-team care providers and opinion leaders. Additionally, understands the inter-relationships both within and between academic centers and utilizes this expertise to enhance Thought Leader and HCP engagements* Consistently incorporates all aspects of the SEM (Scientific Engagement Model) into all interactions, enhancing the quality of interactions and overall relationships as assessed by field coaching observations* Independently incorporates the medical plan into interactions and territory planning (i.e. listening priorities) and captures valuable feedback in the CRM system to inform internal stakeholders and assist in shaping the medical strategy* Possesses an in-depth understanding of the utility and functionality of the CRM system/data analytics tools, allowing for the time sensitive capture of interaction details. Uses CRM/Analytics to enhance future TL engagements and manage workload* Discusses scientific information effectively and compliantly with external stakeholders at an advanced level of communication for both disease state and product to external stakeholders as assessed by management coaching and field observations* In-depth conceptual and practical knowledge of payers in the region and possesses an in-depth understanding of the impact of payers on patient care delivery* Assists clinical development/clinical operations by fully understanding IB content and presenting IB material, providing nominations for trial sites as requested, providing end of study data reviews with investigators (as needed)* Represents Vertex at medical congresses by providing scientific session/abstract coverage, booth staffing coverage, routine TL interactions, contributing to the daily and end of congress summaries and may provide logistical guidance through organizing and scheduling abstract/session coverage and preparing and delivering the conference debrief (as needed)* May serve as a mentor or trainer for colleagues with less experience; for example, assisting with new hire MSL onboarding* Conducts all activities in compliance with Vertex policy and procedures and performs all administrative tasks in a timely manner such as CRM entry, vehicle mileage reporting, expense reporting, calendar entries, training assignments, etc.**Knowledge and Skills:*** Ability to complete goals within allotted timeframes, and deliver high quality results* Ability to help plan and complete projects in a constantly changing field-based environment* Ability to appraise and comprehend medical and scientific literature* Ability to effectively present clinical/scientific information in a credible manner in varied settings* Good knowledge of assigned geographic territory* In-depth understanding of healthcare regulatory environment* Apply proficient knowledge of relevant T1D and T1D management protocols, healthcare environment and landscape to articulate the medical and scientific value of our products* Demonstrated working understanding around the compliance and regulatory frameworks that govern the pharmaceutical industry and conducts compliant interactions with internal and external stakeholders.* In-depth knowledge of payers and unique medical information needs to support access and appropriate use of Vertex medicines* Good knowledge of Health Economics and Outcomes Research* Fluent in English (oral and written)**Education and Experience:*** Minimum requirement for advanced biomedical or life sciences degree (ex. Masters, NP, PA)* Requires minimum of 3-4 years of experience as an MSL supporting Nephrology programs or in other medical affairs roles in the pharma/biotech industry or the equivalent combination of education and experience.* Previous training or experience in designated therapeutic area is helpful Pay Range:$171,300 - $245,000Disclosure Statement:The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.**Company Information**Vertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com. #J-18808-Ljbffr

A leading biotechnology company is seeking an Associate Director for Brand Analytics & Reporting in Boston. This role involves collaborating with various teams to develop and execute comprehensive analytics plans, focused on the Kidney Business Unit. Candidates should have extensive experience in analytics within the pharmaceutical sector and a strong understanding of promotional strategies. The position offers a hybrid or on-site work model and includes a competitive salary range of $157,800 - $236,600. #J-18808-Ljbffr

A leading biotechnology company in Boston is seeking a NA Omnichannel Analytics Director for the Kidney business unit. This role involves developing analytics strategies and leading insights for marketing effectiveness. The ideal candidate has over 10 years of experience in marketing analytics, particularly in the pharmaceutical industry. Strong communication and leadership skills are essential, along with a firm grasp of data analysis tools. Offering a hybrid work environment, this position includes a competitive salary and comprehensive benefits. #J-18808-Ljbffr

Privacy Ops & Assurance Associate Director page is loaded## Privacy Ops & Assurance Associate Directorlocations: Boston, MAtime type: Full timeposted on: Posted Todayjob requisition id: REQ-27365**Job Description****General Summary:**The individual in this position will provide strategic and solutions-oriented advice to a broad spectrum of internal clients on worldwide regulatory issues related to the processing of personal data, including but not limited to the US State Privacy Laws, Section 5 of the FTC Act, CAN-SPAM, EU General Data Protection Regulation (GDPR), and Canadian privacy laws. The role will also support the maturation of privacy-related policies, notices, and SOPs, supporting the strategic direction for the global privacy program and related processes and training.**Key Duties and Responsibilities:*** Performing regular privacy assessments of new and existing business processes (including through data inventories and data protection impact assessments), providing practical and timely advice to internal clients to design business processes in compliance with applicable data protection requirements, including those relating to data transfers, while addressing risks and protecting the company's integrity and reputation.* Acting as subject matter expert and internal escalation point for data protection issues in contracting, including data processing agreements, research collaborations, and transactional agreements; continue to develop template materials for contracting and advise/train members of the legal department on handling privacy-related language in contracts.* Working closely with our contracting teams to improve and streamline contracting processes and procedures related to data protection and security.* Drafting privacy notices and consents for business processes across the organization, and maintaining the organization's privacy and cookie notices on company websites* Developing and reviewing content for privacy training materials and other communications to increase employee understanding of company privacy policies, data handling practices and procedures and legal obligations, as well as to ensure awareness of “best practices” on privacy and data security issues.* Evaluating and responding to data subject requests (e.g., request for information, clarifications, rectification, or deletion of personal data) and reports of potential data incidents. Supporting the monitoring* Supporting the monitoring/auditing plan for compliance with internal data protection policies and processes and working with Internal Audit function, Office of Business Integrity and Ethics or external auditors in carrying out audit plans.* Keeping abreast of privacy developments affecting the company (e.g., evolving guidance out of the European Union, California Privacy Act, discussions of US privacy laws, CAN-SPAM, e-privacy and developments in Artificial Intelligence) and anticipating potential changes needed to global privacy program to meet new regulatory requirements.* Participating in various Legal & Compliance Department projects and initiatives (e.g., Culture, Diversity, & Inclusion Committee, Pro Bono & Community Engagement Committee, Talent & Development Committee, offsite planning, strategic planning).**Knowledge and Skills:*** Consummate team player with excellent judgment and interpersonal skills.* Demonstrable program management skills, including strong organizational and multi-tasking abilities.* Demonstrated teamwork and collaboration skills, in particular in leading or contributing to global and multi-functional teams.* Highly motivated to contribute and grow within a complex area of emerging importance.* Demonstrable experience taking ownership of issues and providing timely, actionable advice.* Exceptional written, oral and presentation skills.**Education and Experience:*** JD from an ABA accredited law school and member of a state bar or Master's degree highly preferred* Minimum of 5 years' experience providing privacy advice, preferably to pharmaceutical, biotechnology, or medical device companies, whether in-house or at a law firm OR experience in management of a corporate privacy program.* Specific expertise required in statutes, regulations and guidance concerning data protection throughout the US and Europe, which could include GDPR and the ePrivacy Directive, CCPA, CPRA, as well as other US privacy requirements (Section 5 of the FTC Act, CAN SPAM, state breach notification laws). Familiarity with data protection statutes and regulations in other areas of the world a bonus.* CIPM, CIPP/US or CIPP/EU certification(s) preferred but not required#LI-DB1#HYBRID**Pay Range:**$168,800 - $253,200**Disclosure Statement:**The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.**Flex Designation:**Hybrid-Eligible Or On-Site Eligible**Flex Eligibility Status:**In this Hybrid-Eligible role, you can choose to be designated as: 1. **Hybrid**: work remotely up to two days per week; **or select** 2. **On-Site**: work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.#LI-Hybrid**Company Information**Vertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com #J-18808-Ljbffr

A leading biopharmaceutical company is seeking an Associate Director of External Manufacturing to oversee Contract Manufacturing Organizations (CMOs) for cell and gene therapy solutions. This role will require a focus on operational oversight, regulatory compliance, and effective project management. The ideal candidate will have over 10 years of experience in the biotech sector, particularly in cGMP environments, and will demonstrate strong leadership and communication skills. This position offers flexible work options, including remote and hybrid arrangements. #J-18808-Ljbffr

A global biotechnology company is seeking a Senior Manager for their Order to Cash function to drive cash flow optimization and manage credit control. This role requires excellent stakeholder management and financial analysis skills. The successful candidate will work closely with various teams, present updates to senior leadership, and have opportunities for personal development in a hybrid-eligible environment. Experience in pharmaceutical or large organizations is preferred. #J-18808-Ljbffr

A leading global biotechnology firm in Boston seeks a Principal Engineer to lead the automation of pre-clinical data pipelines and regulatory reporting solutions. This role focuses on driving modernization and standardization initiatives, leveraging AI technologies, and enhancing data consumption practices. Candidates should possess strong programming skills and a degree in a relevant field, with a minimum of five years in technical leadership within the biotechnology industry. The position offers a hybrid work model and a comprehensive benefits package. #J-18808-Ljbffr

A leading biotechnology company in Boston is seeking an experienced Senior Director, Finance Technology to drive innovation across Financial Systems, focusing on Tax, Treasury, and Accounting. The ideal candidate will have over 12 years of experience in financial systems leadership, strong stakeholder engagement skills, and a passion for technology. This role offers competitive compensation and hybrid work options. #J-18808-Ljbffr

A leading biotech company seeks a qualified professional with extensive experience in compliance investigations and risk management within the pharmaceutical industry. This role involves supporting global initiatives, developing auditing processes, and effective communication across teams. Candidates should have a minimum of 8-10 years of relevant experience, strong analytical skills, and the ability to work with complex data. The position offers a hybrid work model and competitive compensation including bonuses and extensive employee benefits. #J-18808-Ljbffr

A leading biotechnology company in Boston is seeking an Associate Director, GMP Operational Quality to ensure compliance and quality oversight for commercial drug manufacturing. The role includes managing relationships with vendors, mentoring team members, and leading quality improvement initiatives. Candidates should possess strong knowledge of cGMPs, a scientific degree, and extensive experience in quality assurance and project management. This position offers a hybrid work model and competitive compensation package. #J-18808-Ljbffr

A global biotechnology company is seeking a Director of Downstream Process Development in Boston. This role requires advanced leadership skills and expertise in biologics, overseeing the development and optimization of therapeutic biologics with responsibilities in both technical and regulatory aspects. Candidates should have extensive experience with chromatography systems and drug substance development, ensuring compliance with quality standards. Competitive salary range is $195,500 - $293,200, and this is an on-site position. #J-18808-Ljbffr

The External Innovation (EI) Executive Director leads end‑to‑end identification, evaluation, and advancement of external opportunities that materially strengthen Vertex's R&D pipeline across modalities (e.g., small molecules, biologics, CGT, RNA, delivery platforms) and enabling technologies (e.g., discovery, translational, and manufacturing tools). The role orchestrates integrated, cross‑functional analyses and converts opportunity signals into clear, decision‑ready recommendations for EI governance (EI Science, BDSC) and the Executive Committee. Culture & talent: Foster an environment consistent with EI competencies (business‑minded leader, insight generator, influential communicator, trusted partner, change enabler, technical expert).**Required Education:** PhD (or equivalent advanced degree) and 15+ years of biotech/pharma experience spanning discovery and/or early development; or an equivalent combination of education and experience.**Required Experience**Proven ability to build and manage high‑performing analyst teams and to operate an integrated analysis model. **Required Knowledge & Skills**Business acumen: Valuation literacy; option‑value framing; scenario and risk modeling; ability to articulate value drivers and deal concepts (from partnerships to company creation/M&A). Influential communication: Executive‑quality narratives and visuals; clear storyline from problem framing to recommendation; ability to lead with facts and secure alignment. The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.In this Hybrid-Eligible role, you can choose to be designated as: 1. **Hybrid**: work remotely up to two days per week; **or select** 2. **On-Site**: work five days per week on-site with ad hoc flexibility. #J-18808-Ljbffr

A leading biotechnology company is seeking a Director, Global Process Excellence to enhance finance systems and processes integral to scaling operations. This role requires extensive finance experience, capability in project management, and leading cross-functional improvements. The position offers a hybrid work model and competitive salary range of $180,800 - $271,100, along with generous benefits and annual bonus eligibility. #J-18808-Ljbffr

A leading biotechnology company is seeking an Associate Director, Global Pain Market Research to join its Boston team. In this role, you will oversee commercial insights supporting the Global Commercial Strategy for pain management. Key responsibilities include designing primary market research and developing the annual situation analysis. Candidates should have a Bachelor's degree and 8+ years of relevant experience in market research and bio-pharma marketing. Flexible work options are available. #J-18808-Ljbffr

Role Overview & Key Functions: As a Karyopharm, reporting to the Executive Director US Medical Affairs Strategy, you will positively impact patients' lives by: supporting GMSA- US Medical Affairs Strategy projects. Examples include assisting in creating training and operational content for team platforms and dashboards. Helping to build PowerPoint and PDF decks for team presentations. Assisting in strategy projects related to training, performance, analysis and other strategy related projects Responsibilities * Undertake specialized training focused on understanding the disease states relevant to Endometrial Carcinoma. * Collaborate with management to regularly update and maintain various platforms and dashboards. Responsibilities include managing KOL (Key Opinion Leader) trackers, enhancing engagement with clinical trial sites, and updating medical information and insights. * Develop and prepare PowerPoint presentations and Excel spreadsheets to facilitate team presentations and assist in project execution. * Enhance and expand the existing KOL mapping list for endometrial cancer, focusing on improving its functionality and applicability. * Actively participate in diverse projects, collaborating with members of strategy and program teams on assignments that are yet to be finalized. * Assist medical leads in the creation of external educational materials. Contribute to the organization and execution of advisory boards and industry-sponsored symposia. Qualifications * Area of study should be in a business, marketing or healthcare or biomedical sciences related focus with an interest in a career in the medical or biotech field. * A solid foundation of general experience with both PowerPoint and Excel is required and examples of this in the interview process would be beneficial. * Ability to support all time zones in which leadership team resides (US Only) * Virtually meeting skill sets and the ability to complete projects with minimal supervision. Candidate Profile & Requirements: * Must be able to complete the Karyopharm Internship Program 27 May - 08 Aug 2025 * Currently enrolled high school or college (bachelor's program) student * Student must be returning to school in the Fall Term. * Must have a minimum GPA of 3.0 * Must be highly organized and have the ability to work in independently and collaboratively as a team * Clear, concise verbal & written communication Pay for internships ranges from $22 to $30 per hour, depending on the student's academic level (e.g., Bachelor's, Master's) and year in school. Our Value Proposition: At Karyopharm, we live and demonstrate our ICARE values every day! Check out our Culture Video!

A leading biotechnology company in Boston seeks a Senior Director of Global Development FP&A to spearhead financial planning and analysis for clinical trials. The ideal candidate has deep expertise in clinical trial finance, project management, and cross-functional collaboration. Responsibilities include managing complex budgets and providing strategic insights to senior leadership. This hybrid-eligible role offers a competitive salary and benefits package. #J-18808-Ljbffr