Discovery Lead - Women's Health & Musculoskeletal Biology
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
At Lilly, we unite caring with discovery to make life better for people worldwide. As a global healthcare leader headquartered in Indianapolis, Indiana, we are committed to advancing innovation in areas of high unmet medical need. With a proven track record in obesity research and a growing focus on women's health, we seek an experienced discovery leader to help build a portfolio of transformative therapies to improve outcomes for women everywhere and arrest age-related functional decline across genders. This role offers the opportunity to shape strategy, drive impactful drug discovery and development programs, and contribute to Lilly's mission of scientific excellence and patient-centered care.
**Position Summary:**
The Discovery Lead, Women's Health & Musculoskeletal Biology, serves as a pivotal leader responsible for establishing and advancing Lilly's portfolio in Women's Health and Age-related Functional Decline. Indications of interest include PCOS, endometriosis, preeclampsia, menopause-related disorders, osteoporosis and age-related decline in muscle function. We are looking for a dynamic and strategic leader with deep understanding of drug discovery, a passion for developing innovative medicines for areas of high unmet medical need, and a background in metabolic diseases, women's health and/or musculoskeletal biology. This leader will have a track record of identifying novel therapeutic approaches, progressing molecules to the clinic, and leading projects in drug discovery and development. Leading a team of 5-15 preclinical biologists, this role will direct research from target identification through preclinical development and collaborate across disciplines to progress projects through the preclinical and clinical portfolio. An important part of this role is the evaluation and progression of external opportunities: the Discovery Leader will work closely with Lilly's Catalyze 360 and business development organizations to enable the early-stage biotech ecosystem and bring external opportunities into Lilly.
_Portfolio Strategy and Discovery Leadership_
+ Shape Lilly's strategy in Women's Health and Age-related Functional Decline by combining a deep understanding of biology, current therapeutic landscape and competitive environment with evaluation of internal and external opportunities to build an industry-leading portfolio.
+ Collaborate with clinical colleagues, new product planning and senior leadership to set overall program strategy and develop and maintain draft launch labels and value propositions that address key customer needs
+ Lead evaluation of external partnership opportunities, make strategic recommendations to leadership, and ensure scientific leadership through execution and management
_Scientific and Portfolio Leadership_
+ Build, maintain and advance a portfolio of projects that have the potential to transform Women's Health and address key unmet needs in age-related functional decline.
+ Partner closely with bioinformatics to bring computational approaches to bear on target selection and drug discovery
+ Ensure state-of-the art biology capabilities in prioritized areas of Women's Health and Musculoskeletal Biology using internal and external resources.
+ Ensure delivery of quality lead and candidate molecules.
+ Establish and lead partnerships with academic institutions and biotechs to complement internal research efforts.
+ Effectively represent Lilly in interactions with outside partners, key opinion leaders and collaborators. Engage in and lead advisory boards, target and portfolio reviews.
+ Maintain a high scientific profile through publications and presentations
_Team Leadership & Management_
+ Supervise and mentor PhD and non-PhD scientists engaged in target identification, validation and preclinical drug discovery
+ Supervise laboratories. Ensure adherence to all safety, quality and documentation requirements
+ Lead cross-functional teams responsible for novel small and large molecule target discovery and validation
+ Coach team members to think deeply and work creatively while delivering excellent scientific results
**Basic Qualifications:**
+ PhD or MD/PhD with a minimum of 10 years of experience in drug discovery in the pharmaceutical industry.
+ Thorough understanding of drug discovery and development, including regulatory and IP considerations. Proven track record in moving projects forward with contributions to INDs and/or NDAs
+ Significant scientific accomplishments as evidenced by high impact publications, patents or regulatory filings.
+ Track record of successfully managing a diverse set of team-members in an industry setting. Able to deliver effective coaching and feedback.
+ Qualified candidates must be legally authorized to be employed in the United States.
**Additional Skills/Preferences:**
+ Demonstrated ability to drive for results in a fast-paced environment
+ Team-player who excels at working collaboratively while shaping project direction.
+ Strong business sense and strategic planning and execution skills.
+ Strong analytical and problem-solving abilities with excellent self-management and organizational skills.
+ Passionate learner who embraces entrepreneurial thinking
+ Excellent written and verbal communication skills
**Travel:**
Up to 25% US/Global travel
**Location:**
Boston or Indianapolis
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$163,500 - $345,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Scientific Advisor - ADME Project Leadership for Biologics
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Our diverse ADME team is seeking a dedicated and enthusiastic scientist interested in the discovery and clinical development of medicines across multiple modalities, with a particular emphasis on biologics and drug conjugates. If you have a talent for finding creative solutions to complex problems, apply today! We want you on our team.
Our scientifically agile team works collaboratively with biologists, chemists, engineers and various other R&D functions to deliver novel therapies to patients. We support one another through shared-learning and mutual-responsibility for the enterprise of making medicines. Ours is a flexible environment where each team member can optimize their productivity while being mindful of wellness. This enables each of us to grow our careers as well as the scientific field in our search for safe and effective medicines. Please connect with us if you are a motivated and collaborative scientist looking for an opportunity to innovate at the forefront of novel therapies to improve the lives of patients.
**A high-quality candidate will demonstrate the following:**
+ High learning agility and a keen ability to derive and efficiently test ADME and DMPK hypotheses for novel molecules with particular emphasis on antibodies
+ Strong working knowledge in fundamental pharmaceutics, pharmacokinetics and ADME principles especially as they relate to biologics such as antibodies and conjugated molecules
+ Understanding of contemporary pharmaceutical regulatory guidance and expectations
+ Skills to integrate internal and external laboratory and other experimental resources through high quality scientific associations
+ Agile interrogation of diverse data (e.g., in silico, in vitro, in vivo) to derive mechanistic understanding of drug action and performance characteristics
**Lilly-ADME seeks a skilled ADME / DMPK scientist who will:**
+ Lead and innovate in a multidisciplinary collaborative environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly portfolio
+ Design and implement hypothesis driven studies to answer ADME, PK/PD and clinical pharmacology questions
+ Integrate ADME, PK and PK/PD endpoints with discovery biology data to define structure activity- and structure-property-relationships to guide drug delivery and optimization strategies
+ Engage, innovate, and collaborate with colleagues and interdisciplinary teams
+ Lead the preparation of regulatory communication and documents to support clinical development, new drug applications (NDA and BLA) and line extensions and interact with regulatory agencies worldwide
+ Build and foster relationships through coaching and mentorship with fellow scientists
+ Possess excellent written and verbal technical communication skills and the ability to lead, guide and influence teams in decision making
**Location:**
Onsite presence (minimum of 3 days/week) at either our headquarters in Indianapolis, Indiana, or our Harborside location in Boston, Massachusetts
**Basic Requirements:**
Ph.D. in Biology, Cellular or Molecular Biology, Biochemistry, Pharmaceutical Sciences, Pharmacokinetics or a related scientific field; experience in the discovery and development of biological-therapeutics highly preferred
**Additional Skills/Preferences:**
+ Industry (Pharma/Biotech) experience (1- 7 years) in the preclinical evaluation of biologics and or hybrid modalities, as well as relevant ADME project leadership experience
+ Understanding of and experience with immunoassays, and/or LC/MS bioanalytical methodology
+ Detailed understanding of pharmacokinetics, ADME and proficiency to communicate theory and concepts clearly
+ Experience in drug discovery and development
+ Experience with PK/PD modeling and/or bio-distribution
+ Ability to balance multiple projects and handle competing responsibilities
+ Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community
+ Excellent oral and written communication skills
+ Experience authoring regulatory and technical reports
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$151,500 - $244,200
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Scientific Director - ADME Project Leadership for Biologics
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Lilly's Drug Metabolism and Pharmacokinetics (DMPK) team is searching for an experienced pharmaceutical scientist to lead the application of absorption, distribution, metabolism, excretion (ADME) science to advance our portfolio. Working on cross-functional teams, our diverse group is multidisciplinary, applying in vitro, in vivo, and in silico approaches to mechanistically study the pharmacokinetics, absorption, and disposition of biologics/antibodies. You will serve as technical leader within the department and across portfolio cross-functional teams. This role will require engaging in experimental design and data interpretation to deliver the discovery and development portfolio of investigational targets and novel therapeutics. We are passionate about making an impact in the lives of our patients. Consider joining our efforts!
Responsibilities:
- Accountable for the delivery of scientifically integrated data packages to guide compound selection, study design, portfolio decisions, and regulatory submissions.
- Partner with cross-functional colleagues in both Discovery and Development (eg. Toxicology, Pharmacology, Chemistry, Clinical PK/PD, Clinical Pharmacology, Regulatory, and Medical) to assess drugability and optimize ADME properties to deliver drug candidates to the clinic, as well as to design and support nonclinical and clinical studies, supporting global registration packages.
- Lead R&D initiatives to grow and develop ADME/DMPK capabilities for across experimental and drug modalities including biologics/antibodies.
- Integrate in vitro, in vivo, and in silico ADME data with Biology and Chemistry understanding to define structure-activity- and structure-property-relationships and deliver favorable molecular and experimental design strategies.
- Prepare data packages and develop content in regulatory documents (eg. IB, IND, IMPD, NDA/BLA, etc.) to support global regulatory submissions (including sections 2.6.4./non-clinical pharmacokinetics and 2.7.2./clinical pharmacology) and correspondence as well as represent ADME in face-to-face discussions with regulators.
- Guide junior, peer, and upper level scientists in best and modern practices of multi-property optimization through the use of mechanistic ADME principles.
- Effectively partner to apply innovative PBPK approaches to translate and predict human PK, inform clinical plans and support registration.
- Communicate the value of mechanistic ADME approaches both internally within R&D and externally including regulatory agencies.
- Build a strong external network (e.g. academia, consortia) and keep up to date with emerging literature and science in the area.
Basic Qualifications:
Ph.D. degree in Pharmacokinetics, Pharmacology, Pharmaceutics, Biochemistry, or related field with 6 years or more of extensive training in the field of drug metabolism and disposition or clinical pharmacology.
Additional Skills/ Preferences:
- Experience in drug discovery and development across a variety of therapeutic areas.
- Experience with biologics/antibodies.
- Detailed understanding of pharmacokinetics, ADME, drug interactions and proficiency to communicate theory and concepts clearly.
- Ability to balance multiple projects and handle competing responsibilities.
- Experience with modeling software (e.g. SimCYP, GastroPlus, NONMEM, Matlab, etc.).
- Demonstrate strong communication skills with the ability to integrate diverse perspectives, adroitly deliver critical messaging, and influence leaders/key partners.
- Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$168,000 - $294,800
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Director/Senior Director, CMC, Drug Product Development
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
**Job Summary**
The Director/Senior Director, CMC, Drug Product Development will lead formulation development activities across multiple dosage forms and therapeutic modalities, with a focus on developing and incorporating digital solutions and tools into drug product workflows. The ideal candidate will bring expertise in both parenteral and solid oral dosage forms, combined with emerging capabilities in computational and AI-driven formulation approaches. Success in this role requires cross-function collaboration and leadership as well as a strategic vision for how technology can be leveraged to transform traditional drug development activities.
**Key Responsibilities**
Formulation Development
+ Lead formulation design, development and external manufacturing for both parenteral (IV, SC, IM) and solid oral (tablets, capsules) drug products across diverse therapeutic programs and modalities
+ Develop robust formulation strategies that address in vivo performance, stability, bioavailability, manufacturability, and patient-centric considerations
+ Manage a network of external providers (CROs, CDMOs) with capabilities in drug product development and manufacturing
+ Author CMC sections of regulatory submissions (IND, CTA) related to drug product development and manufacturing
+ Support regulatory interactions and respond to health authority questions
+ Ensure compliance with cGMP standards and ICH guidelines
Digital Solution Development
+ Lead the development, testing and implementation of digital solutions related to drug product development
+ Partner with IT and other internal drug product subject matter experts to translate drug product workflows into requirements that can be incorporated into technology solutions
+ Lead the evaluation of in silico modeling tools and AI/ML platforms that predict formulation performance and accelerate development timelines
+ Continuously monitor the industry trends, competitive landscape and emerging technologies to identify future tools and technology platforms of interest
**Minimum Requirements**
+ Education: PhD in Pharmaceutical Science or related field (Chemistry, Chemical Engineering, Pharmacy)
+ 8+ years of pharmaceutical industry experience
+ 3+ years of prior experience with application of in silico tools or AI/ML solutions in drug product development
**Additional Skills/Preferences**
+ Experience working with multiple therapeutic modalities (small molecules, biologics, peptides, oligonucleotides)
+ Experience with both parenteral and solid oral formulations
+ Knowledge of emerging modalities including cell & gene therapy, RNA-based medicines
+ Strong analytical and problem-solving skills
+ Experience working with biotechs/emerging companies and/or early-stage development programs where speed to clinic is a critical success factor
+ Demonstrated ability to operate effectively in fast-paced environments where rapid decision-making and pragmatic problem-solving are essential to maintain program momentum
+ Track record of supporting multiple concurrent programs with varying levels of technical maturity, demonstrating agility in shifting priorities and creative approaches to address emerging challenges
**Additional Information**
+ Remote options may be considered based on business needs
+ Travel up to 10%
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$148,500 - $257,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
ADME Project Leadership for Genetic Medicines
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Our diverse ADME team is seeking a dedicated scientist with an interest in the discovery and clinical development of genetic medicines, including si RNAs, ASOs, mRNAs, gene editing, and gene therapy. We are committed to advancing scientific boundaries to develop transformative therapeutics that address the underlying causes of diseases across a wide range of therapeutic areas. Applicants with strong problem-solving abilities and innovative thinking are encouraged to apply to join our team at the expanding Boston campus.
Lilly's agile ADME team collaborates closely with biologists, chemists, engineers, and various other R&D functions to deliver novel genetic medicines to patients. Team members support each other through shared learning and collective responsibility for all stages of the discovery and development process for next-generation genetic therapies. We strive to foster professional growth while advancing science to provide safe and effective new treatments to patients. Prospective candidates who are motivated, collaborative scientists interested in spearheading innovation in genetic medicine therapies are invited to connect with us and contribute to improving patient outcomes globally.
**A high-quality candidate will demonstrate the following:**
+ High learning agility and a keen ability to articulate and efficiently test ADME and DMPK hypotheses for complex novel molecules
+ Strong working knowledge in fundamental pharmaceutics, pharmacokinetics/pharmacodynamics, and ADME principles - especially as they relate to novel genetic medicine therapeutic modalities
+ Understanding of pharmaceutical regulatory guidance and expectations
+ Agile interrogation of diverse data (e.g., in silico, in vitro, in vivo) to interpret complex data sets and to derive mechanistic understanding of drug action and ADME/DMPK characteristics
**Lilly seeks a skilled ADME / DMPK scientist who will:**
+ Lead and innovate in a multidisciplinary team environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly genetic medicines portfolio
+ Design, implement, and interpret hypothesis-driven studies to inform key ADME, PK/PD, and toxicokinetic (TK) questions
+ Integrate ADME, PK and PK/PD endpoints with discovery chemistry and biology data to guide preclinical drug design, optimization, and delivery strategies.
+ Engage, innovate, and collaborate with cross-functional colleagues and interdisciplinary teams
+ Lead the preparation of ADME portions of regulatory communications and documents to support clinical development, new drug applications, and line extensions and interact with global regulatory authorities
+ Mentor and support junior scientists and build relationships through coaching and mentorship with fellow scientists at all levels
+ Possess excellent written and verbal technical communication and the ability to constructively lead, guide and influence teams
**Basic Requirements:**
Ph.D. in Biochemistry/Biology/Pharmacokinetics/Bioengineering/Pharmacology or a related scientific field
Greater than five years of experience as a scientist in a pharmaceutical and/or biotechnology company in a role related to ADME or PK/PD
**Additional Skills/Preferences:**
+ Knowledge of DMPK and/or bioanalytical considerations for gene editing therapeutics
+ Experience with PK/PD modeling and simulation
+ Experience with targeted delivery and biodistribution of oligonucleotides and/or gene therapies
+ Understanding of and experience with PCR, immunoassay, and/or LC/MS bioanalytical methodology
**Additional Information:**
This is a full-time position located in Boston, MA.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$184,500 - $321,200
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Computational Infrastructure Scientist - Biological Data Systems
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
We are seeking a Computational Infrastructure Scientist to help build and extend the data systems that power large-scale biological and genetic research - the foundations of modern biology and precision medicine.
This is a scientific engineering position, ideal for a PhD-level scientist who bridges biology, computation, and informatics. The successful candidate will have a deep understanding of the complexity and diversity of biological and genetic data, and a passion for designing robust, reusable infrastructure that makes this data usable, reproducible, and scalable across research and discovery pipelines.
You will work at the intersection of genetics, bioinformatics, data architecture, and software engineering, designing systems that transform how biological and clinical-genomic information is prepared, integrated, and explored. Your work will involve:
+ Developing and extending **data models and ontologies** that harmonize heterogeneous sources of biological, genetic, and clinical information.
+ Designing scalable **data ingestion, standardization, and transformation pipelines** for genomic and functional datasets.
+ Collaborating with domain experts in **genomic medicine** , **computational biology** , **bioinformatics, genetics,** and **informatics** to ensure that infrastructure design supports high-impact scientific use cases.
+ Support and develop scientific workflows that impact the drug discovery portfolio
+ Building the frameworks that enable **semantic interoperability** , **metadata-rich data exchange** , and **traceable, reproducible data workflows** .
+ Contributing to the evolution of **open data standards** and **knowledge representation** across the life sciences.
+ The ideal candidate combines scientific curiosity with engineering discipline - someone who finds beauty in well-designed systems and efficiency in well-structured data.
**Responsibilities**
+ Strategize and implement scientific data processing workflows that transform complex biological datasets into actionable insights.
+ Design and develop innovative algorithms and ETL systems to address emerging challenges in biological and drug discovery data integration.
+ Collaborate cross-functionally with domain scientists and engineers to translate biological questions into computational frameworks.
+ Contribute to the long-term architecture and evolution of the data platform, ensuring scalability, transparency, and reproducibility.
+ Develop cloud-based workflows and APIs that enable efficient access and analysis across diverse biological datasets.
+ Document and share design decisions to promote reuse and institutional knowledge.
**Basic Qualifications:**
+ PhD in Computational Biology, Chemistry, Bioinformatics, or a related scientific field.
**Additional Skills/Preferences:**
+ Strong programming experience in **Python** **and strong familiarity with R.**
+ Experience working in **Linux environments** .
+ Knowledge of biological databases, ontologies, and metadata systems.
+ Knowledge in PostgreSQL databases
+ Proficiency in **Linux environments** and **Git** (required).
+ Exposure to **cloud platforms** (e.g., AWS S3, EC2, or equivalent).
+ Experience working with workflow execution environments including NextFlow
+ Experience developing data-driven decision support applications including data and visual analytical tools
+ Exposure to Docker or containerized environments.
+ Strong communication skills and the ability to work independently on open-ended technical problems.
+ Understanding of web design and API is a plus.
**What We Offer**
+ A unique opportunity to shape the data infrastructure that underpins next-generation biological research.
+ Cross-functional exposure with state-of-the-art discovery
+ A role combining **scientific insight** with **engineering autonomy** .
+ Hands-on experience with **cloud computing** and modern data architecture.
+ A collaborative environment focused on rigor, transparency, and impact.
+ The chance to become a **core steward** of a critical research platform and its long-term sustainability.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$151,500 - $244,200
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Statistical Genetics Platform Engineer
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
The Lilly research environment is evolving to centralize the access and analysis of human genetic data. This new initiative will work to define data, tools and process to provide the therapy area teams key evidence for target evaluation and target discovery.
Many different therapy areas across Eli Lilly focus on new therapeutic approaches for the treatment of many different diseases. Starting from an idea, we work with partners across Lilly to discover and develop novel biologic, small molecule and nucleic acid-based therapeutics. Our focus is the patient: by understanding the biology and pathophysiology underlying disease states, we aim to address the root cause of disease and develop breakthrough therapies. We have one of the strongest pipelines in the industry and a track record of delivering impactful medicines that improve people's lives.
In this hands-on role, the Statistical Genetics Platform Engineer will join a team that enables statistical geneticists to derive scientific insights from internal and external human genetic data. The ultimate purpose being to drive data-driven decision-making within the organization. The successful candidate will collaborate with team members and also with data engineers and platform architects across the Lilly research environment. The goals of the collaboration will include identifying genetically-based disease targets, finding potential expanded clinical indications for existing assets, classifying and validating patient subpopulations, and understanding disease mechanisms. The role will support these goals by developing robust computational pipelines that leverage harmonized clinical datasets. This role is a great opportunity to be at the forefront of scientific exploration in a dynamic research field.
Interested in working on an innovative team focusing on providing clear evidence for therapeutic targets? Apply today!
**Key Responsibilities:**
+ Design and implement robust, scalable computational pipelines for statistical genetics analyses, including workflows for GWAS, polygenic risk scores, fine-mapping, colocalization and variant annotation
+ Develop and maintain platform tools and APIs that enable researchers to efficiently process genomic data at scale (biobanks, population cohorts, multi-omics datasets)
+ Build infrastructure for reproducible research, including containerization, workflow orchestration, and version control for analytical pipelines
+ Optimize computational performance of statistical genetics algorithms and implement distributed computing solutions for large-scale analyses
+ Collaborate with statistical geneticists and computational biologists to translate methodological innovations into production-ready software
+ Establish best practices for data access, quality control, validation, and documentation across genomic analysis pipelines
+ Maintain and improve existing codebases, ensuring code quality, testing coverage, and comprehensive documentation
+ Monitor platform performance, solve issues, and implement improvements based on user feedback and evolving research needs
+ Support the integration of AI-based tools and required MLOps infrastructure
**Basic Requirements:**
+ Master's in Computer Science, Statistical Genetics, Bioinformatics or related field and 6+ years post-Master's experience (in industry or large-scale non-academic institutions, e.g. Broad, NIH),
+ OR PhD in Computer Science, Statistical Genetics, Bioinformatics or related field and 3+ years post-PhD experience (in industry or large-scale non-academic institutions, e.g. Broad, NIH)
**Key Requirements:**
+ Strong programming skills in languages commonly used in genomics research (Python, R)
+ Demonstrable understanding of statistical genetics concepts including GWAS, heritability estimation, genetic correlation, rare variant analysis, and population structure
+ Experience using standard tools and formats for genetic data (VCF, BGEN, PLINK, BAM/CRAM) and genomic databases
+ Proficiency with workflow management systems (Nextflow, Cromwell/WDL) and containerization technologies
+ Experience with high-performance computing environments, cloud platforms (AWS, GCP, Azure), or distributed computing frameworks
+ Strong problem-solving abilities and attention to detail in handling complex biological datasets
+ Ability to prioritize and manage multiple competing priorities within a fast-paced environment
**Additional Skills/Preferences:**
+ Demonstrated track record performing end-to-end analysis of human genetic data
+ Familiarity with operationalizing statistical genetics tools like plink, ADMIXTURE, regenie, VEP, LDSC, FINEMAP, SuSiE, coloc, METAL, LDpred2, MAGMA, rvtest (rare variants), SNP-int GPU (epistasis)
+ Experience performing complex analyses in cloud-based environments required; prior experience with DNANexus and/or DataBricks is preferred
+ Experience with large-scale biobanks and their trusted research environments is preferred.
+ Experience of querying data for analysis through SQL (e.g. PostgreSQL), no SQL (e.g. Elasticsearch), data stores (e.g. hail), graph databases (e.g. neo4j) and file storage (e.g. S3)
+ Experience working with additional data formats, including RNA-seq, metabolomic, and proteomic data
+ Experience with protein language models and/or sequence language models
+ Experience working with clinical data
+ Experience working with electronic health record data
+ Knowledge of AdAM and OMOP formats
+ Strongly team-oriented with a customer focused design thinking approach
+ Knowledge of drug development process and how genomics data is used to impact these areas
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$166,500 - $266,200
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Clinical Research Physician
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Verve, a wholly owned subsidiary of Eli Lilly, is seeking a Clinical Research Physician to lead the clinical trial efforts for our innovative gene editing therapies targeting cardiovascular disease. In this key role, you will provide medical oversight and strategic leadership throughout the trial lifecycle, ensuring scientific integrity, regulatory compliance, and patient safety. You will collaborate with cross-functional teams, contribute to regulatory submissions, and help implement biomarker strategies. This high-visibility position offers the opportunity to drive clinical development and engage with key external stakeholders. The ideal candidate will excel in a fast-paced, dynamic environment and possess strong communication skills and attention to detail.
**Job Responsibilities**
+ Provide medical oversight and strategic leadership throughout the clinical trial lifecycle, including the design, planning, execution, and interpretation of trials for investigational compounds, ensuring patient safety and scientific integrity.
+ Contribute to the design and development of key clinical documents, including study protocols, investigator's brochures, informed consent documents, and other essential materials.
+ Ensure the clinical development strategy adheres to industry best practices and regulatory guidelines while collaborating with study investigators and medical experts in the development and execution of study protocols.
+ Lead the review and interpretation of clinical trial data, including safety assessments, efficacy endpoints, and overall trial progress.
+ Serve as a key medical expert in cross-functional discussions, including regulatory submissions, investigator meetings, and advisory boards.
+ Work with the Clinical Operations team to identify and resolve trial-related issues, ensuring smooth execution and compliance.
+ Collaborate closely with the clinical operations, regulatory, and data management teams to ensure timely and high-quality execution of clinical trials.
+ Collaborate with the research team to develop and implement a translational biomarker strategy for the program integrating early-phase data to inform clinical strategy.
+ Contribute to regulatory submission efforts by providing clinical insight into IND submissions, clinical trial applications, and other regulatory documents support responses to health authorities and ethics committees.
+ Represent the company at scientific conferences, advisory boards, and meetings with regulatory authorities.
+ Develop and maintain relationships with external stakeholders, including key opinion leaders (KOLs), clinical investigators, and contract research organizations (CROs).
+ Foster a collaborative and positive team environment that encourages innovation, scientific rigor, and high-performance standards.
+ Travel to clinical sites, conferences, and regulatory meetings as needed.
+ Other duties as assigned.
**Qualifications:**
+ **Minimum Requirements**
**Medical Doctor must be board eligible or certified in a medical specialty relevant to the role or have completed the comparable level of post-medical school clinical training relevant to the country of hiring. U.S. trained physicians must have achieved board eligibility or certification. Foreign medical graduates in U.S. based jobs, who are not U.S. board eligible or certified may be hired directly for employment in the U.S. at the discretion of the Chief Medical Officer.**
**Non-U.S. trained physicians must have completed education and training at a medical school that meets the requirements of the Liaison Committee on Medical Education (LCME). For the recognized list of foreign medical schools and the disapproved list, see** ************************************************************************************************************************************************************************
+ **Preferred Qualifications**
+ Clinical or research experience in cardiology or endocrinology
+ At least 7 years of relevant experience.
+ At least 2 years of experience overseeing the execution of clinical trials, preferably within an industry setting; ideal candidate might have experience with gene therapy/editing programs or early phase clinical development
+ Strong knowledge of clinical trial design, regulatory requirements, GCP guidelines, and industry best practices.
+ Proven ability to interpret clinical trial data, experience serving as medical monitor on a clinical trial, including safety assessments and efficacy endpoints, and apply it to inform decision-making.
+ Leadership skills with the ability to collaborate effectively with cross-functional teams and external stakeholders.
+ Excellent communication and presentation skills, with the ability to represent the company at scientific conferences, advisory boards, and regulatory meetings.
+ Ability to develop relationships with key opinion leaders (KOLs), clinical investigators, and contract research organizations (CROs).
+ Familiarity with translational biomarker strategies and integration of early-phase data into clinical development plans is a plus.
+ Ability to travel to clinical sites, conferences, and regulatory meetings as needed.
+ Collaborative mindset, fostering innovation, scientific rigor, and high performance in a team setting.
+ Strong problem-solving skills with the ability to resolve trial-related issues and ensure smooth execution.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$240,000 - $389,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Director - Neuroscience
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
We are seeking a highly motivated scientific laboratory leader with a solid background in Neuroscience to join our growing Psychiatry, Pain and Neuronal Health Team within Neuroscience Discovery Group at Lilly's Indianapolis Lilly Research Laboratories site. The ideal candidate will be a critical thinker with a deep understanding of Neuroscience and neuronal plasticity, with an emphasis on psychiatric and neurodevelopmental disorders. Successful candidates will have demonstrated abilities to lead a laboratory in industry and/or biotech that provides critical and robust decisional data. Demonstrated ability to develop preclinical in vivo biomarker assays, such as EEG, for translational early clinical phase development is desirable. The candidate will be an integral part of multiple cross-functional teams focused on developing novel medicines across broad neurological and psychiatric disorders. There is an expectation of effective communication skills and the ability to work collaboratively across the multiple geographies of Lilly's research sites, and strong leadership of cross-functional teams.
Overall Responsibilities:
+ Supervise a group of dedicated laboratory neuroscientists.
+ Lead cross-functional teams in preclinical drug development phase.
+ Present data and conclusions to leadership and decision makers in a clear, balanced, and compelling manner.
+ Identify, develop, and implement innovative approaches to add functional capabilities and gain new insights into psychiatric and neurological disease biology, target engagement and pharmacodynamics.
Basic Qualifications:
+ PhD in Biology, Biochemistry Neuroscience, Neurophysiology, or related scientific discipline with 10+ years industry or academic experience beyond any postdoctoral positions.
+ Alternatively, a Masters degree in Neuroscience, Neurophysiology, or related scientific discipline with 20+ years industry or academic work experience leading a laboratory and leading discovery projects through preclinical development
Additional Skills/Preferences:
+ Clear understanding of pharmacology principles and measures of target engagement _ex vivo_ or _in vivo_ to drive human dose projections.
+ Demonstrated ability to lead a cross-functional team and translate preclinical biomarkers to clinical development.
+ Experience preparing document for regulatory filings.
+ Excellent communication and presentation of scientific skills.
+ Ability to work both independently and in cross-functional teams, as well as influencing beyond direct reports.
+ Demonstrated expertise in Neuroscience research as evidenced by peer reviewed publication record.
Additional Information:
+ 20-30% travel
+ On Site position at Lilly Coporate Center in Indianapolis, Indiana and/or Lilly Seaport Innovation Center in Boston, Massachusetts
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$144,000 - $250,800
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Director - AAV Process Development Research
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Come join the exciting Gene Therapy team at Eli Lilly! We are responsible for inventing, characterizing, and advancing our novel gene therapy platform for a myriad of clinical applications. Our team works cross-functionally within our organization across multiple therapeutic areas and platforms. Our goal is to deliver on the promise of gene therapy to patients around the world.
The Lilly Genetic Medicine Team is seeking an experienced and inspiring scientific leader to join our fast-paced, interdisciplinary team as we leverage novel genetic-based therapeutic modalities to enhance and advance the Lilly portfolio. The successful applicant will utilize their knowledge, core technical expertise and people management to enable the next generation of AAV clinical gene therapy. Key facets of the role include the ability to lead a group of scientists that are progressing an innovative preclinical portfolio, help create the future of AAV technology with focus on scientific rigor and discovery research in gene therapy and interface with formal GMP manufacturing.
The Lilly Genetic Medicine team strives to operate as an agile and autonomous 'biotech-like' company within Lilly. Successful execution of our gene therapy strategy requires excellence in both basic and applied sciences. We are looking for creative and energetic problem solvers to work in a multidisciplinary team across the breadth of the Lilly organization to achieve the company's objectives for future pipeline growth and value for the patient.
**Job Responsibilities:**
The successful candidate will manage an experienced group of scientists engaged in upstream and downstream AAV vector production discovery, research and early development. The candidate's specific responsibilities will include management of established projects, close collaboration with formal GMP manufacturing scientists, driving innovation in AAV process development, participation with senior management in evaluation of new therapeutic opportunities in gene therapy, and close collaboration with various therapeutic area scientists.
+ Provide leadership and maintain technical expertise to improve implementation of genomic technologies within LGM
+ Execute on research and development that strives to improve scalable processes
+ Integrate and execute LGM strategy, provide clarity for teams to prioritize and focus.
+ Develop and effectively coach talent and scientific leaders by developing critical skills, providing actionable feedback, and managing workloads.
+ Assist in capability building, project prioritization and resource allocation across the editing team, taking into account critical stakeholders
+ Monitor and adjust deliverables and timelines as the team marches towards their objectives throughout the year.
+ Focus on talent evaluation and opportunities to maximize full career potential of LGM employees.
+ Work closely with LGM Operations as programs progress
+ Keep safety as a top priority at all times, striving toward a proactive safety culture.
+ Inspire people to collaborate in inventing genetic medicines by removing barriers, committing to high quality scientific hypotheses, act with speed and agility in the face of ambiguity.
+ In partnership with other resource owners, be responsible of resourcing decisions in genetic medicine across portfolio and platforms.
+ Be an advocate for diversity and inclusion in our recruiting, retaining and developing scientists, with a commitment to coaching and development of scientists.
**Basic Requirements:**
+ PhD in chemistry, engineering, pharmaceutical sciences, or related scientific field.
+ 7 to 10+ years of industry experience leading process development research, with emphasis on AAV proficiency being preferred
**Additional Skills/Preferences:**
+ Experience leading diverse and high performing research groups
+ Proven experience in design, implementation, and upkeep of genetic medicines pipelines
+ Demonstrated knowledge of Pharmaceutical Discovery & Development
+ Experience in leading groups of researchers including PhD level scientists
+ Strong relational skills, demonstrated ability for efficient collaboration, prioritization and establishing effective work environments
+ Ability to think strategically, actively identifying gaps in competencies or capabilities within the organization and taking initiative to drive continuous improvement across Genetic Medicine.
+ Prior work in internal and external tech transfer
+ Collaborative work ethic
+ Experience working in a matrixed environment
+ Impeccable organizational skills
**Additional Information:**
+ Travel to engage collaborative functions within Lilly required occasionally
+ This position will be located in the Boston Seaport location
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$158,250 - $275,000
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Computational Biologist - Obesity Research
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
The Diabetes, Obesity and Complications Therapeutic Area (DOCTA) of Eli Lilly and Company focuses on new therapeutic approaches for the treatment of diabetes, obesity and cardiometabolic diseases. Starting from an idea, we work with partners across Lilly to discover and develop novel biologic, small molecule and nucleic acid-based therapeutics. Our focus is the patient: by understanding the biology and pathophysiology underlying disease states, we aim to address the root cause of disease, and develop breakthrough therapies. We have one of the strongest pipelines in the industry and a track record of delivering impactful medicines that improve people's lives.
Are you a computational scientist passionate about addressing some of the most pressing global health challenges of our time? Do you stay current with the latest advances in metabolic disease research and obesity pathophysiology? Are you eager to apply pioneering computational and statistical approaches to analyze multi-omics data and unravel the complex biology of obesity, adipose tissue function and metabolic dysregulation?
The computational biology role within DOCTA is an exciting opportunity for a team-oriented scientist with deep expertise in obesity biology and computation methods to drive therapeutic discovery in metabolic diseases. In this hands-on role, you will work cross-functionally with researchers across DOCTA to design and implement multi-omic studies specifically focused on obesity pathophysiology, energy regulation, adipose tissue biology, metabolic pathway dysregulation and CNS pathways concerning obesity. You will collaborate closely with experimental project leads and scientific domain experts to drive scientific discovery through the comprehensive analysis of single-cell genomics data from preclinical models and human studies. In this role, you will not only apply established computational methods to understand obesity pathophysiology and identify novel therapeutic targets in metabolic pathways, but also pioneer the application of innovative AI/ML approaches to extract deeper biological insights from complex multi-modal datasets. The successful candidate will have the opportunity to directly impact the DOCTA pipeline, ultimately driving the scientific field forward and bringing innovative therapies to patients.
**Key Responsibilities:**
+ Design and complete studies using omics-related data sources, including RNA-seq, spatial transcriptomics, single-cell omics, proteomics, functional genomics, metabolomics, and more.
+ Integrate standard analytical approaches as well as emerging AI/ML models to answer scientific questions of high-dimensional data
+ Partner with discovery statistics team to create novel analytical frameworks for high-throughput studies and develop specialized methodologies to enhance insights from small-sample datasets.
+ Stay up-to-date on current technical and scientific advances through deep understanding of the literature and attendance of relevant technical and disease-related conferences
+ Clearly communicate complex results to cross-functional partners in a prompt and transparent manner
+ Perform ad-hoc bioinformatics analyses and data visualizations as needed
+ Work collaboratively with other Data Sciences and Computational Biology (DSCB) scientists to develop innovative, best in class computational workflows and data repositories for advanced analyses
+ Engage in code and documentation review within the team and across other teams within the DSCB team
+ Adhere to industry-standard protocols for scientific project documentation
**Basic Requirements:**
PhD or equivalent in Computational Biology, Bioinformatics, Biomedical Informatics, or related field with 2+ years of experience post-PhD in relevant disease area.
**Additional Skills/Preferences:**
+ Strong track record of execution of computational biology and/or bioinformatics-based projects, potentially including RNA-seq, metabolomics, multi-omics, human genetics, proteomics, AI/ML, and other related research modalities required
+ Prior experience and deep expertise in obesity and related areas, preferably with data from preclinical models, patient cohorts or cell lines preferred
+ Expertise in programming languages including R and Python and experience with workflow management systems such as Nextflow required
+ Experience developing production-grade bioinformatics pipelines, including working with standardized workflow tools preferred
+ Experience with implementation and maintenance of industry-standard documentation practices including Git, Confluence, JIRA, or equivalent preferred
+ Ability to prioritize and manage multiple competing priorities within a fast-paced environment required
+ The ability to communicate complex scientific and computational concepts to non-computational and non-scientist audiences required
+ Ability to represent the DOCTA DSCB team internally and externally required
+ Strongly team-oriented thinking mentality required
+ Prior industry experience preferred
+ Experience with scalable cloud computing platforms (e.g. Databricks, AWS) and big data analytics frameworks preferred
+ Experience with containerized technologies (e.g. Docker) for computational reproducibility preferred
+ Knowledge of human genetics preferred
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$138,000 - $224,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Advisor, guide-RNA Process Development
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
**Organizational Overview**
Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company within Lilly Research Labs, is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company's initial three programs - VERVE-101, VERVE-102, and VERVE-201 - target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the _PCSK9_ gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the _ANGPTL3_ gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia.
**Position Summary:**
We are seeking an experienced process chemist to join the guide-RNA process development team. You will be joining a team that is heavily focused on clinical manufacturing process development. This is primarily a lab-based role supporting guide-RNA drug substance process development for programs in clinical development. The role will also contribute to the development of guide-RNA manufacturing platform technologies in a highly collaborative effort with process and analytical chemistry teams.
**Responsibilities:**
+ Design and execute solid-phase synthesis and purification experiments to support process development and scale-up of oligonucleotide drug substance manufacturing
+ Lead guide-RNA process development efforts by identifying areas of continuous improvement through literature and state-of-art practices and applying these learnings to Verve's gRNA process development projects.
+ Collaborate cross-functionally with process and analytical teams to progress process and manufacturing technology development projects
+ Review and provide technical feedback on internal and external collaborators experimental designs and results
+ Participate actively in technical discussions and meetings, proactively communicate technical findings and results to stakeholders, train and support teammates as needed
+ Partner closely with members of facilities, lab operations, and safety to maintain the highest level of safety standards within the lab
+ Keep an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed
**Basic Requirements:**
+ PhD degree in a relevant scientific discipline with 1-2+ years of industry experience (synthesis, oligonucleotide development, solid phase synthesis, CMC) or MS degree with 6+ years of relevant industry experience (synthesis, oligonucleotide development, solid phase synthesis, CMC)
+ Experience designing and troubleshooting oligonucleotide solid phase synthesis studies. Strong preference for candidates who have experience with guide-RNA or longmer synthesis development backgrounds.
+ Experience with oligonucleotide manufacturing processes and equipment including solid phase synthesis (Cytiva OligoSynt or OP100), cleavage and deprotection, chromatography (Akta), TFF, sterile filtration, single-use technology, and sterile/aseptic processing preferred
+ Background in oligonucleotide process development, scale-up, and GMP manufacturing
+ Strong communication skills (oral and written) and the ability to thrive in a team and goal driven environment
**Additional Skills/Preferences:**
+ Background in CRISPR guide RNA development strongly preferred
+ Use of strong interpersonal skills for collaboration
+ Ability to prioritize multiple activities and handle ambiguity
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$138,000 - $224,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Machine Learning Scientist/Sr Scientist, Federated Benchmarking & Validation Engineering
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
**Purpose**
Lilly TuneLab is an AI-powered drug discovery platform that provides biotech companies with access to machine learning models trained on Lilly's extensive proprietary pharmaceutical research data. Through federated learning, the platform enables Lilly to build models on broad, diverse datasets from across the biotech ecosystem while preserving partner data privacy and competitive advantages. This collaborative approach accelerates drug discovery by creating continuously improving AI models that benefit both Lilly and our biotech partners.
The Machine Learning Scientist/Sr Scientist, Federated Benchmarking & Validation Engineering plays an essential role within the TuneLab platform, responsible for identifying, assessing, and implementing cutting-edge algorithmic solutions that leverage diverse datasets while ensuring data privacy and security for our biotech partners. This position requires comprehensive knowledge in small molecule drug development, ADME/Tox, antibody engineering, and/or genetic medicine, combined with expertise in data science and statistical analysis to develop sophisticated models utilizing federated learning. This position will be instrumental in advancing both Lilly's pipeline and our partners' drug discovery efforts by designing critical algorithms and workflows that expedite the creation of transformative therapies.
This role centers on constructing robust validation frameworks for federated models, creating privacy-preserving test sets across partner datasets, establishing standardized benchmarks against public datasets, and ensuring model reproducibility and generalization in diverse deployment scenarios.
**Key Responsibilities**
+ **Federated Test Set Design** : Architect and implement privacy-preserving protocols for constructing representative test sets across distributed partner datasets, ensuring statistical validity while maintaining data isolation.
+ **Benchmark Suite Development** : Create comprehensive benchmark suites covering small molecules (ADMET, solubility, permeability), antibodies (affinity, stability, immunogenicity), and RNA therapeutics (stability, delivery, off-target effects).
+ **Cross-Domain Validation** : Develop validation strategies that assess model generalization across different experimental protocols, cell lines, species, and therapeutic indications while respecting partner data boundaries.
+ **Public Dataset Integration** : Systematically benchmark federated models against public datasets (ChEMBL, PubChem, PDB, Therapeutic Antibody Database) to establish performance baselines and identify gaps.
+ **Validation Frameworks** : Implement time-split or proper scaffold-split validation protocols that assess model performance on prospective data, simulating real-world deployment scenarios and detecting concept drift.
+ **Reproducibility Infrastructure** : Build robust MLOps pipelines ensuring complete reproducibility of federated experiments, including versioning of data snapshots, model checkpoints, and hyperparameter configurations.
+ **Statistical Rigor** : Design statistically powered validation studies accounting for multiple testing, hierarchical data structures, and non-independent observations common in drug discovery datasets.
+ **Performance Profiling** : Develop comprehensive performance profiling across diverse molecular scaffolds, target classes, and property ranges, identifying systematic biases and failure modes.
+ **Platform Integration** : Collaborate with engineering teams to integrate validation frameworks with the TuneLab federated learning platform built on NVIDIA FLARE, ensuring scalable and automated testing across partner networks.
**Basic Qualifications**
+ PhD in Computational Biology, Bioinformatics, Cheminformatics, Computer Science, Statistics, or related field from an accredited college or university
+ Minimum of 2 years of experience in the biopharmaceutical industry or related fields, with demonstrated expertise in drug discovery and early development
+ Strong foundation in experimental design, statistical validation, and hypothesis testing
+ Experience with ML model validation, cross-validation strategies, and performance metrics
+ Proficiency in data engineering, pipeline development, and automation
**Additional Preferences**
+ Experience with federated learning platforms and distributed computing
+ Knowledge of regulatory requirements for AI/ML in pharmaceutical development
+ Expertise in ADMET assay development and validation
+ Understanding of antibody engineering and characterization methods
+ Familiarity with RNA therapeutic design and delivery systems
+ Experience with clinical biomarker validation and translational research
+ Proficiency in workflow orchestration tools (Airflow, Kubeflow, Prefect)
+ Strong knowledge of containerization and cloud computing (Docker, Kubernetes)
+ Publications on model validation, benchmarking, or reproducibility
+ Experience with GxP compliance and quality management systems
+ Exceptional attention to detail and commitment to scientific rigor
+ Strong technical writing skills for regulatory documentation
+ Portfolio mindset balancing rigorous validation with rapid deployment for partner value
This role is based at a Lilly site in Indianapolis, South San Francisco, or Boston with up to 10% travel (attendance expected at key industry conferences). Relocation is provided.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$151,500 - $244,200
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Financial Services Agency Owner
Braintree Town, MA job
Become a Financial Services Agency Owner with us to get into a new and exciting opportunity on a referral, part-time, or full-time basis. Support your own community and North America by educating how individuals can grow and protect their financial future.
Responsibilities & Requirements:
- Business Expansion
Educate individuals to optimize their financial resources.
Pass the State Life & Health Insurance Exam within 9 months of being approved. Optional Securities License Exams.
Compensation:
Multiple streams of income, including passive income
Executive Director - Mass Spectrometry-based Biomarker Discovery - Neuroscience
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Lilly's Neuroscience Research team is at the forefront of developing cutting-edge therapies and diagnostics for brain disorders. Biomarkers play a crucial role in clinical trials, providing insights into patient selection, therapeutic efficacy, safety, and mechanisms of action. We seek an accomplished biomarker expert, who has vast experience in mass spectrometry-based work. The successful candidate will lead our efforts in biomarker discovery and validation, enabling the diagnosis and treatment of neurodegenerative conditions. As Executive Director (or potentially Associate Vice President) you will drive the strategic and technical development of biomarker assays that are instrumental in the advancement of our neuroscience pipeline. The role will be situated at Lilly's research facilities in Boston, within a newly established unit led by Dr. Kaj Blennow, Vice President of Neuroscience Biomarker Development. you will oversee and mentor a skilled team of biomarker researchers, fostering innovation and scientific excellence
**Key Responsibilities:**
+ Lead the development and validation of novel mass spectrometry-based biomarker assays for early- and late-phase clinical trials in neurodegenerative diseases, including Alzheimer's, Parkinson's, ALS, and rare brain disorders.
+ Oversee and mentor a team of biomarker researchers at Lilly's laboratories in Boston, focusing on mass spectrometry-based assay development.
+ Serve as a scientific and technical expert for in-house and outsourced biomarker discovery efforts, guiding experimental study design and analytical strategies.
+ Collaborate cross-functionally with internal stakeholders (medical, operations, statistics, regulatory) and external partners (CROs, academic institutions) to ensure biomarker validation and successful integration into clinical programs.
+ Communicate findings through presentations, publications, and strategic discussions, reinforcing Lilly's leadership in biomarker innovation.
**Basic Qualifications:**
+ PhD in Neuroscience, Biochemistry or a related field, with 8+ years of industry, academic, or postdoctoral experience experience in biomarker development, with recognized expertise in mass spectrometry-based assays for brain diseases.
**Preferred Skills & Experience:**
+ Proven leadership in managing and mentoring biomarker research teams in academic or industry settings.
+ Deep knowledge of mass spectrometry technology including instrument setup, optimization and maintenance.
+ Deep understanding of mass spectrometry-based assay development, validation, and regulatory requirements for biomarker applications in clinical trials.
+ Strong strategic thinking, problem-solving abilities, and the ability to drive innovation in biomarker discovery.
+ Excellent communication, collaboration, and negotiation skills to influence both internal and external stakeholders.
+ Demonstrated ability to translate scientific insights into impactful clinical applications.
Join Lilly in shaping the future of neuroscience by advancing biomarker-driven precision medicine. If you are a leader in biomarker discovery looking to make a meaningful impact, we invite you to apply.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$184,500 - $321,200
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Associate Vice President - Women's Health & Early Clinical Development
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
**Position Summary:**
The Associate Vice President (AVP), Women's Health & Early Clinical Development, serves as a pivotal leader responsible for establishing and advancing Lilly's Women's Health portfolio. We are looking for a dynamic and strategic leader with deep understanding of women's health physiology, pathophysiology and clinical care, and a passion for developing new medicines to advance women's health. The ideal candidate will have a track record of impactful translational and/or clinical research related to women's health, and a demonstrated ability to progress new medicines as part of a drug development team. Responsibilities of the role include directing research and clinical development programs through Phase 2, liaising with drug discovery scientists, external innovation, late phase development and commercial colleagues to evaluate and progress new therapeutic opportunities, and advancing external collaborations and strategic partnerships to drive impactful outcomes for women's health. The AVP will shape and execute strategies for both internal and external portfolio growth, and will collaborate closely with enterprise leaders to align scientific research and development with overarching company objectives.
We are seeking a candidate with an MD or MD/PhD in gynecology or reproductive endocrinology, who specializes in the health of the female reproductive system and has provided comprehensive care for conditions including menstrual disorders, preeclampsia, infertility, menopause, and osteoporosis. Experience as a clinical researcher in academia or expertise in pharmaceutical drug development is essential.
**Position Responsibilities:**
_Portfolio Strategy and Clinical Planning_
+ Shape Lilly's strategy in Women's Health by combining a deep understanding of current therapeutic landscape and competitive environment with evaluation of internal and external opportunities to build an industry-leading portfolio.
+ Develop project concepts, investment strategies and clinical development plans that that allow for efficient assessment of new therapeutic approaches and targets
+ Collaborate with new product planning to develop and maintain Draft Launch Labels and Value Propositions that address key customer needs
+ Contribute to and lead innovative drug discovery and development projects
+ Serve as medical expert in interactions with external partners and during assessment of business development opportunities
_Clinical Research, Trial Execution and Support_
+ Collaborate with clinical research staff in design, conduct and reporting of clinical trials
+ Review and approve risk profiles to ensure appropriate communication to study subjects
+ Assist in planning and participate in study start-up meetings and other activities to provide the appropriate training and information to investigators and site personnel.
+ Participate in investigator identification and selection
+ Ensure that operational team has documented the completion of administrative requirements for study initiation and conduct consistent with Good Clinical Practices and local laws and requirements.
+ Serve as resource to clinical operations personnel / clinical research monitors, investigators and ethical review boards to address any questions or clarify issues arising during the conduct of study.
+ Understand and actively address the scientific information needs of all investigators and personnel.
+ Monitor patient safety during the conduct of studies and conduct the appropriate tracking and follow-up of adverse events
+ Knowledge of clinical research methodology including latest developments in relevant areas of biomarkers, efficacy measures, diagnostic practices, study designs, safety evaluations and regulatory standards.
_Regulatory Support Activities_
+ Support / assist in the preparation of regulatory reports, including INDs, FDA annual reports, regulatory responses and Periodic Adverse Drug Experience Reports (PADERS), preparation for FDA communication and resolution of regulatory issues, including regulatory response, from a global perspective. Provide medical expertise to regulatory scientists.
+ Participate in face-to-face meetings with FDA, EMEA and other regulatory bodies
+ Participate in risk management planning along with affiliates and Global Patient Safety.
_Data Dissemination and Scientific Exchange_
+ Participate in data analysis and preparation of final reports and publications. Prepare or review scientific information in response to internal or external questions.
+ Participate in and lead scientific disclosures and publications.
+ Support and lead the planning of symposia, advisory board meetings, and other meetings with health care professionals.
+ Establish and maintain appropriate collaborations and relationships with external experts, thought leaders, and the general medical community on a national and international basis.
+ Represent Lilly in external forums where standards, common protocols, assessment instruments, regulatory standards and clinical practice guidelines relevant to women's health are discussed
+ Develop and maintain appropriate collaborations and relationships with relevant professional societies.
+ Knowledge of and compliance with local laws and regulations, and global policies and procedures, compliance guidelines with respect to data dissemination and interactions with external health care professionals.
_Scientific / Technical Expertise and People Development_
+ Maintain and disseminate within Lilly information on latest developments in the pathophysiology, diagnosis, etiology, treatment and management of women's health. Critically read and evaluate the relevant medical literature.
+ Be aware of current trends and projections for clinical practice and access in the therapeutic area(s) relevant to the priority areas
+ Actively set and meet individual professional development goals
+ Contribute to the development of others by acting as mentor and coach to co-workers
**Basic Qualifications:**
+ MD or MD/PhD. Must be board eligible or certified as gynecologist or reproductive endocrinologist or have completed the comparable level of post-medical school clinical training relevant to the country of hiring.
+ Clinical trialist with a track record of developing clinical plans and execution of studies in the pharmaceutical industry
+ Minimum of five years experience in clinical research/drug development in academia or industry including the design and implementation of large global clinical trials.
+ Minimum of five years experience in clinical practice with at least 2 years in Women's health.
+ Qualified candidates must be legally authorized to be employed in the United States.
**Additional Skills/Preferences:**
+ Team-player with proven ability to shape project direction and influence stakeholders
+ Demonstrated ability to drive for results in a fast-paced matrixed environment Innovation mindset with a passion for novel therapies
+ Strong business acumen and strategic planning and execution skills
+ Excellent written and verbal communication skills
**Physical Demands/ Travel:**
The physical demands of this job are consistent with light office duties. Up to 20% US/Global travel.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$291,000 - $453,200
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Scientist - Mass Spectrometry
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing, and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.
The LIGM RNA Group is seeking an experienced analytical scientist with extensive hands-on experience in analytical techniques for characterizing and analyzing small molecules, biologics, and/or oligonucleotides. The ideal candidate will have a proven track record in analytical method development and troubleshooting, as well as experience with liquid chromatography, (high resolution) mass spectrometry, and other advanced analytical techniques.
They must possess strong technical problem-solving skills, be computer savvy with the ability to navigate multiple instrument control programs and data analysis environments, and be able to work independently to achieve efficient, quality results in a fast-paced environment.
**Responsibilities:**
+ Work closely with the chemistry team to source, explore, and implement the latest separation science and analytical technologies for the purification and characterization of oligonucleotides and their conjugates, including carbohydrates, lipids, peptides, and proteins.
+ Conduct LC and LC-MS based method development for sensitive characterization of biologics including intact mass, reduced mass, peptide mapping, and glycan mapping to provide better understanding of attributes.
+ Conduct semi-preparative and preparative method development activities to advance downstream processing for challenging modified oligonucleotides, utilizing RP purification, ion-exchange chromatography, spin filtration, TFF, FPLC, size exclusion chromatography, and MS-direct auto-scale preparative LC-MS techniques.
+ Work with contractors and third-party vendors to troubleshoot and maintain lab instruments, including but not limited to UPLC, LC-MS, osmometer, and NanoDrop, ensuring they remain in peak operational condition.
+ Learn new technologies quickly and apply effective scientific concepts and methods across multiple areas.
+ Process and present data leveraging Microsoft Office apps, GraphPad and Spotfire for data organization and data visualization.
+ Document experiments, data, technical reports, and findings electronically in an accessible manner with good documentation practices.
+ Present findings, progress, and data proactively and regularly in group and department meetings.
+ Possess a collaborative and willing-to-share mindset with excellent verbal and written communication skills, presentation skills, and attention to detail.
+ Ability to follow Global Health, Safety & Environment Center (HSE) guidelines while performing tasks.
**Basic Qualifications:**
Bachelor's or Master's degree in Analytical Chemistry, Biochemistry, Chemistry, Food Science, or a related scientific field, with over 2 years of relevant post-graduate experience in industry.
**Additional Skills/Preferences:**
+ Strong analytical thinking skills with a demonstrated ability to articulate issues and extract and synthesize complex information into key focus areas.
+ Extensive experience in operating and troubleshooting a range of mass spectrometers including Q-ToF, QQQ and Orbitrap
+ Proficient with Thermo XCalibur, Agilent ChemStation and MassHunter software.
+ Understanding tandem mass spectrometry and interpretation of MS/MS based characterization of including but not limited to peptide, peptide-oligonucleotide conjugates, and lipid conjugates.
+ Extensive hands-on experience in downstream workflows for small molecules, biologics, and oligonucleotides. Experience with antibody-drug-conjugates (ADCs) or antibody-oligonucleotide-conjugates (AOCs) is a plus.
+ Proven expertise in liquid chromatography including ion-pair reverse phase liquid chromatography as well as ion chromatography.
+ Prior experience in native mass spectrometry and understanding of electrospray ionization as well as molecular behavior in the gas phase.
+ Prior experience in proteomics, bioanalysis, and/or CMC is a significant advantage.
+ Highly self-motivated and self-driven attitude with ability to own and drive projects into success.
+ Strong organizational and communication skills and effective people skills.
+ Capable of continuous learning, open-minded, highly organized, and detail oriented.
+ Ability to balance multiple activities, prioritize and handle ambiguity.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$71,250 - $187,000
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Associate Director - Clinical Operations
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
**Organization Overview**
Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company within Lilly Research Labs, is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company's initial three programs - VERVE-101, VERVE-102, and VERVE-201 - target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the _PCSK9_ gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the _ANGPTL3_ gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2024, Verve was named a Top Place to Work by The Boston Globe for the fourth consecutive year. Verve is headquartered in Boston, Massachusetts.
**Responsibilities:**
+ Drive and oversee all aspects of clinical studies from planning to close-out, ensuring adherence to timelines, budgets, and regulatory guidelines (FDA, EMA, GCP, ICH) using a risk-based approach.
+ Develop and implement operational plans for clinical studies, managing CROs and vendors to ensure high-quality execution.
+ Lead internal clinical trial team meetings, tracking key study metrics (e.g., enrollment, site feasibility, and data collection) to ensure progress and alignment with company goals.
+ Partner with cross-functional teams (e.g., Clinical, Regulatory, Supply Chain) to support the strategic development and execution of clinical programs.
+ Partner with cross-functional team and CRO to ensure patient recruitment and retention strategies are carried out effectively to facilitate on-time study enrollment.
+ Ensure efficient database lock by overseeing monitoring plans and taking part in data review and reconciliation efforts.
+ Contribute to the development and review of key regulatory documents (e.g., Protocol, Investigator Brochure, Clinical Study Report, Informed Consent Forms, patient-facing materials, and vendor plans).
+ Assist in maintaining a quality-focused clinical infrastructure by developing, revising, and implementing SOPs to ensure operational consistency with GXP standards across trials and programs.
+ Engage in the planning of quality assurance activities and coordinate remediation of audit findings.
+ Lead vendor selection, contract/budget negotiation, and management (including RFP generation, review of SOWs, and Change Orders), serving as a point of escalation as needed.
+ Develop and maintain project budget forecasts, ensuring efficient resource allocation, cost-effective execution, and punctual review of invoices.
+ Provide ongoing oversight, maintenance and evaluate completeness of the Trial Master File (TMF) by performing periodic QC reviews to ensure the TMF is always "inspection ready".
+ Lead, mentor, and develop a high-performing team by fostering collaboration, resolving challenges, and ensuring peak performance. Provide training and guidance to junior staff to support their growth and expertise in clinical operations.
+ Set clear objectives, delegate responsibilities, and drive strategic alignment with company priorities.
+ Cultivate an inclusive and collaborative culture, empowering team members and reinforcing company values.
+ Tackle complex challenges by integrating diverse perspectives into innovative, actionable strategies.
+ Make data-driven decisions, providing insightful recommendations to shape project timelines, goals, and resource allocation.
+ Build strong relationships with senior management and external partners, influencing key project outcomes and ensuring strategic alignment.
+ Partner with internal teams and external partners to ensure seamless execution of clinical studies. Foster strong relationships across departments to align objectives, streamline workflows, and drive strategic decision-making.
**Basic Qualifications/Requirements:**
+ Bachelor's degree in a life science, allied health field, or other relevant field (e.g. nursing, medical or laboratory technology).
+ At least 9 years of relevant experience.
**Additional Skills/Preferences:**
+ Proven ability to lead teams, manage projects, and solve complex problems.
+ Strong communication skills, with the ability to persuade and influence partners in sensitive, high-impact situations.
+ High emotional intelligence, with the ability to manage both your own emotions and those of others, fostering a collaborative and positive work environment.
+ Skilled in conflict resolution and maintaining relationships in challenging scenarios.
+ Experience managing contracts, budgets, resources, and schedules to meet performance and project requirements.
+ Strategic thinker with the ability to clarify and structure ambiguous problems.
+ Experience in policy development and implementation with potential company-wide effects.
+ Ability to build and maintain strong team dynamics, proactively preventing and resolving challenges.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$127,500 - $187,000
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Postdoctoral Scientist - Antibody-RNA Conjugation, Genetic Medicine
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
We serve an extraordinary purpose. For more than 140 years, we have worked diligently to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our world's greatest health challenges.
At the Lilly Innovation Center in Boston Seaport, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system. Our team in Boston shares a real passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center offers a start-up environment with large company support. It is located in the heart of Massachusetts' exploding science and technology cluster and is within walking distance of some of the best academic and industry innovators in the world.
We are seeking a highly motivated postdoctoral fellow to join our Genetic Medicine team at Eli Lilly in Boston MA. The successful candidate will possess a strong background in synthetic organic chemistry and experience in molecular design. They will be responsible for designing, synthesizing, and characterizing novel linkers for drug conjugates, with a focus on effective extrahepatic delivery. As part of a platform team, this individual will formulate linker chemistry strategies and investigate kinetics of payload-linker release to advance the RNA modality. Success in this role requires ability to solve complex problems, challenge the status-quo, and excel in communication and collaboration within a multidisciplinary team-oriented environment.
**Job Responsibilities:**
+ Develop novel linker strategies for antibody-RNA conjugates and bioconjugation methodologies. Design and synthesize novel linkers for controlled drug release.
+ Collaborate closely with ADME teams to develop robust bioanalytical methods and to investigate PK/PD relationships for antibody-RNA conjugates.
+ Contribute to optimization of internal antibody-RNA conjugate workflow.
+ Work productively and safely in the laboratory; and maintain good practice in writing experimental reports in an electronic lab notebook.
+ Communicate experimental results and project progress with supervisor and at team/department meetings.
+ Publish/share original research externally (presentations, peer-reviewed articles, and conferences).
**Basic Qualifications:**
+ Ph.D. in synthetic chemistry, chemical biology, or related scientific field
**Additional Skills/Preferences:**
+ Extensive knowledge of cutting-edge modern organic chemistry, linker design and complex molecule synthesis.
+ Understanding advanced analytical and purification techniques.
+ Experience in antibody-drug conjugates and/or oligonucleotide chemistry will be preferred.
+ Proficiency in independently executing research tasks.
+ High learning agility in the field of new scientific concepts and drug modalities.
+ Strong problem-solving skills with creative solutions in constructing complex molecular systems.
+ A proven track record of significant contributions to research projects, substantiated by first or co-authorship on peer-reviewed scientific publications.
+ A track record of productive collaborations in interdisciplinary team environment.
+ Excellent communication and organizational skills
**Additional Information:**
+ This position is not permanent. It is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years. You will have opportunities to apply for full time positions after your duration is complete
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$58,000 - $100,320
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly
Director - Mass Spectrometry-based Biomarker Discovery - Neuroscience
Lilly job in Boston, MA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Lilly's Neuroscience Research team is dedicated to the advancement of innovative therapies and diagnostics for the treatment of neurological disorders. Biomarkers are of paramount importance in clinical trials, providing essential insights into patient stratification, therapeutic efficacy, safety profiles, and elucidation of mechanisms of action. We are currently seeking an individual of exceptional expertise in biomarker discovery, with a demonstrated track record in mass spectrometry-based methodologies. The successful candidate will play a pivotal role in guiding our biomarker discovery and validation strategies, thereby supporting both the diagnosis and therapeutic management of neurodegenerative diseases. In the capacity of Director, the incumbent will assume responsibility for both the strategic direction and technical execution vital for the development of biomarker assays critical to the progression of our neuroscience portfolio. The role will be situated at Lilly's research facilities in Boston, within a newly established unit led by Dr. Kaj Blennow, Vice President of Neuroscience Biomarker Development.
**Key Responsibilities**
+ Development and validation of novel mass spectrometry-based assays for early- and late-phase clinical trials in neurodegenerative diseases, including Alzheimer's, Parkinson's, ALS, and rare brain disorders.
+ Work with project team leads, and mentor junior associates to design and execute in vitro experiments to support both the preclinical and clinical characterization and evaluation of therapeutic molecules through biomarker assay development.
+ Assist with the planning and execution of method development, optimization, and sample analyses, working with internal and external partners to coordinate readouts for complex studies.
+ Implement assay validation procedures to deliver high performance biomarker assays for preclinical and clinical sample analyses.
+ Serve as a scientific and technical expert for in-house and outsourced biomarker discovery efforts, establishing experimental study design and analytical strategies.
+ Collaborate cross-functionally with internal stakeholders (medical, operations, statistics, regulatory) and external partners (CROs, academic institutions) to ensure biomarker validation and successful integration into clinical programs.
+ Communicate findings through presentations, publications, and strategic discussions, reinforcing Lilly's leadership in biomarker innovation.
**Basic Qualifications**
+ PhD in Neuroscience, Biochemistry or a related scientific field, with 5+ years of industry, academic, or postdoctoral experience in biomarker development, with recognized expertise in mass spectrometry-based assays for brain diseases.
**Additional Skills/Preferences:**
+ Must have deep understanding of the mass spectrometry technology and instrumentation as well as mass spectrometry-based assay development and validation for biomarker applications in clinical trials.
+ Must be technically skilled to independently execute advanced mass spectrometry-based studies.
+ Proven leadership in managing and mentoring biomarker research teams in academic or industry settings.
+ Strong strategic thinking, problem-solving abilities, and the ability to drive innovation in biomarker discovery.
+ Excellent communication, collaboration, and negotiation skills to influence both internal and external stakeholders.
+ Demonstrated ability to translate scientific insights into impactful clinical applications.
Join Lilly in shaping the future of neuroscience by advancing biomarker-driven precision medicine. If you are a leader in biomarker discovery looking to make a meaningful impact, we invite you to apply.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ******************************************************* ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$184,500 - $321,200
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
\#WeAreLilly