Salary Grade 07 for staff working 37.5 hours per week
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Job Description
POSITION OBJECTIVE
Working under moderate supervision. Perform research work in molecular and biochemical-related technical areas involving lab/ research skills; analyze samples-record results for a particular or closely related series of experiments. All the DNA templated processes like DNA repair, replication, and transcription require access to the DNA sequence. Therefore, maintenance of chromatin structure is an integral component to deter physiological responses, including inflammation and premature Aging. Excitingly, lifespan can be extended by manipulations that reverse the age-dependent changes to chromatin structure, indicating the pivotal role chromatin structure plays during Aging. This position will work with mice.
ESSENTIAL FUNCTIONS
- Perform research work in medical and related technical areas involves using lab skills. Various Mice models will be used in the study, and the technician will be trained for mice work under supervision. Conduct PCR, qPCR, Extract nucleic acids and Protein, Running Gel electrophoresis, Mouse Cell Culture, preparation of buffers, Epigenetic study using ATAC, RNA, and Histone Modification sequencing. DNA methylation assays. (60%)
- Conduct analysis of samples. Analyze qPCR data, protein quantification, and perform buffer calculation. (10%)
- Record results for a particular experiment or closely related series of experiments. All the lab experiments will have to be recorded daily, including the protocols and results. (10%)
- Maintain records of experiments and detail lab activities, reagents, etc. The experiments include nucleic acid, protein purification, genome-wide library preparation for next-generation sequencing ( ATAC, RNA, ChIP, MNase, Methylation sequencing), and quantification of prepared libraries using Qbit and Fragment analyzers. (10%)
NONESSENTIAL FUNCTIONS
- Maintain test equipment utilized in experiments. Maintain lab stock of reagents daily. ( 5%)
- Order laboratory supplies and reagents. (4%)
- Perform other duties as assigned. (1%)
CONTACTS
Department: Daily contact with supervisor to discuss research and maintain workflow.
University: Occasional contact with other departments to share information.
External: Limited or no contact with vendors to exchange information.
Students: Contact student employees to exchange information.
SUPERVISORY RESPONSIBILITY
This position has no direct supervision of staff employees.
QUALIFICATIONS
Education/Experience: Bachelor's degree in science and 0 to 1 year of experience or Associate's degree in an approved biotechnology program and 0 to 2 years of experience required.
REQUIRED SKILLS
- Knowledge of commonly-used concepts, practices, and procedures within protein biology. Should The research assistant for this position should know basic concepts of DNA, RNA, and protein biology and be able to successfully isolate nuclei acids from a small amount of mice tissues and cell lines, Protein estimation, cell and tissue isolation from mice, and good verbal and presentation skills.
- Relies on instructions and pre-established guidelines to perform the functions of the job.
- Ability to operate laboratory equipment, such as centrifuges, horizontal gel electrophoresis machines, and Pipettes.
- Ability to meet consistent attendance.
- Ability to interact with colleagues, supervisors, and customers face to face.
- Must demonstrate compliance with CWRU animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
- Must demonstrate compassion for animals within CWRU facilities and dedication to the Animal Resource Center's mission. Must handle animals with care and respect at all times.
- Previous experience working with animals preferred.
WORKING CONDITIONS
The employee needs protective eyewear, a laboratory coat, and appropriate Gloves General laboratory environment. In addition, they may have exposure to hazards such as chemicals and lab reagents.
Case Western Reserve University's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals" appropriate Federal Animal Welfare Regulations, and the Public Health Service "Policy on the Humane Care and Use of Laboratory Animals." This position, and all animal research personnel, are subject to internal compliance to medical school Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.
Diversity Statement
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
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Reasonable Accommodations
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
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COVID Vaccination
Case Western Reserve University has implemented a COVID Vaccination policy requiring evidence of COVID-19 vaccination for all students, faculty and staff with an on-campus presence. Religious and medical exemptions may be provided in accordance with applicable federal and state laws. For more information go to: Applicants may contact the Office of Equity at / for information regarding religious or medical exemptions as an accommodation.