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In 2014, Mirati & Array set out to create a successful molecule.
Ostrem, Jonathan M., Shokat, Kevan M. “Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design.” Nat Rev Drug Discov 15.11 (2016): 771-785.
Campbell et al, Nature Genetics 2016 “Distinct patterns of somatic genome alterations in lung adenocarcinomas”
Simanshu, Dhirendra K. et al. “RAS proteins and their regulators in human disease.” Cell 170.1 (2017): 17-33.
January 2019, first patient in Phase 1/2 clinical trial of MRTX849, a direct KRASG12C inhibitor, is dosed and shows first clinical data in October 2019.
SAPPHIRE trial kicks off mid-2019 and begins enrolling patients.
Early in 2020, KRASG12D inhibitor candidates advance into IND-enabling studies.
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| Company name | Founded date | Revenue | Employee size | Job openings |
|---|---|---|---|---|
| Clovis Oncology | 2009 | $148.8M | 468 | 1 |
| Tango Therapeutics | 2017 | $42.1M | 91 | 9 |
| Salarius Pharmaceuticals | 2011 | $5.2M | 5 | - |
| Cyteir Therapeutics | 2012 | $1.6M | 26 | - |
| Oncternal Therapeutics | 2013 | $785,000 | 13 | - |
| G1 Therapeutics | 2008 | $82.5M | 148 | 2 |
| Onconova Therapeutics | 1998 | $226,000 | 12 | - |
| IDEAYA Biosciences | 2015 | $7.0M | 69 | 6 |
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Mirati Therapeutics may also be known as or be related to MIRATI THERAPEUTICS INC., Mirati Therapeutics, Mirati Therapeutics Inc, Mirati Therapeutics Inc. and Mirati Therapeutics, Inc.