Optinose Leadership

Per G Djupesland, MD, Ph.D. is the inventor of the patented, bi-directional nasal drug delivery technology and the main Founder of OptiNose. He has been Chief Scientific Officer (CSO) of OptiNose since 2000 and is in charge of the research activities at OptiNose, as well as, ongoing clinical studies designed to demonstrate the broad advantage of the bi-directional delivery system, including the recently completed Phase II studies in nasal polyposis, migraine and chronic rhinosinusitus. Per is an Otorhinolaryngologist (ORL) with a specialization in rhinology and has a Ph.D. in the field of nasal physiology and aerodynamics from the University of Oslo. He is world renowned expert, with over 25 years of clinical experience also spanning ORL, infectious diseases, epidemiology and surgery. He has been Clinical Research Fellow at the Hospital for Sick Children and Toronto General in Toronto, Canada, primarily studying the role of Nitric Oxide in the upper airways. His Ph.D. is focused on nasal physiology and aerodynamics in infants. Per is the author of over 80 articles in international medical journals, has lectured at numerous conferences and has filed 35 patent families/patent applications. He holds a MD from University of Oslo 1982, Diplom d´Úniversite´ (Master) from Paris, France and a Ph.D. from the University of Oslo

Peter became involved with OptiNose after accepting a request to join the Company’s Board in 2008. While serving in this role he became familiar with OptiNose’s unique drug delivery technology and was convinced of the significant potential of the product. In 2009 Mr. Miller, in coordination with the original founders, led a significant capital raise allowing OptiNose to move forward with clinical trials and the commercialization process. In 2010 he also accepted the role of CEO. Since then, Mr. Miller has overseen the relocation of the Company’s headquarters from Oslo, Norway, to Yardley, PA, and the expansion of the OptiNose team. He also remains a member of the Company’s Board of Directors. Mr. Miller was previously the Co-Founder, CEO and President of Take Care Health Systems a company which revolutionized healthcare by operating medical clinics inside Walgreen’s retail pharmacies. Along with co-founder Hal Rosenbluth, Peter helped create an industry which is seen as transformational innovation that is disrupting the U.S. Healthcare system. Peter, with co-founder, conceptualized the idea, hired a world-class management team, raised over $90 million in private equity/venture and sold their company to Walgreens in less than 4 years. Mr. Miller served as a vice president in the Walgreens Health and Wellness Division and remained CEO for Take Care Health Systems for 3 years after the sale to Walgreens and grew the clinic operation to over 400 clinics nationwide. Prior to founding Take Care Health Systems, Mr. Miller worked for health care industry leader Johnson & Johnson. Mr. Miller served in a variety of marketing and general management roles and was Worldwide President of Johnson & Johnson - Merck Consumer Pharmaceuticals, a $500 million dollar consumer pharmaceutical company and President of Janssen Pharmaceutica a $4 billion dollar pharmaceutical company. During his 15 year career with Johnson & Johnson, Mr. Miller also played an integral role in building multimillion and multibillion-dollar brands such as Tylenol, Motrin, Imodium, Pepcid, Duragesic, Risperdal and Aciphex. Mr. Miller earned an economics degree from Trinity College and an M.B.A. from the Kellogg School of Management at Northwestern University.

Michael Marino is a Chief Legal Officer/Secretary at OPTINOSE, INC. and Board Member at OPTINOSE, INC. and is based in Philadelphia, Pennsylvania. He has worked as VP/Secretary/General Counsel at NUPATHE INC; Senior VP/Secretary/General Counsel at FIBROCELL SCIENCE, INC.; and Lawyer at MORGAN LEWIS & BOCKIUS LLP. Michael studied at Boston College Law School between 1998 and 2001 and Villanova University between 1994 and 1998.

President and COO of a growth stage Specialty Healthcare Company that I have led through development of 2 products from pre-IND to FDA approval with additional research programs ongoing. Responsible for leading all R&D and scientific activities, commercialization functions, manufacturing/supply chain, regulatory/quality, business development, and multiple other functions. After one of the most successful biopharma IPOs of 2017 and supported by multiple pre- and post-IPO funding rounds, our team is rapidly growing revenue and working to improve life for millions of people.Previously, Chief Medical Officer & Global Management Board member at the Ethicon group of companies at JNJ, responsible for worldwide Pre-Clinical Research, Clinical Development, Medical Affairs, and Health Economics & Reimbursement. Prior to that, worked 12 years in JNJ pharmaceuticals with positions in R&D, Outcomes Research, and Medical Affairs, culminating as management board member of Janssen and Vice President, Medical and Scientific Affairs for Janssen and McNeil Pediatrics. Earned a Doctor of Medicine from the Honors Program in Medical Education at the University of Miami, a Master’s Degree from Harvard, and board certifications in Public Health/Preventive Medicine and Internal Medicine. During 10 years U.S. Army active duty, filled roles including battalion surgeon and flight surgeon, earning multiple commendations and decorations. Served in various patient care, teaching, and research positions, culminating as head of the Department of Epidemiology at the Walter Reed Army Institute of Research and inaugural leader of a policy research/analysis activity supporting the Assistant Secretary of Defense (Health Affairs).Internationally recognized scientist, having co-authored over 80 publications in peer-reviewed journals, including the New England Journal and Annals of Internal Medicine, contributor to R&D programs for many new drug and device products, a scientific reviewer for multiple journals, and a prior member of an NQF Advisory Committee and the examination subcommittee of the ABPM.

Victor Clavelli joined Optinose in February 2020 as Chief Commercial Officer for Optinose. Mr. Clavelli had an accomplished 20-year career at Pfizer where he held leadership roles including responsibilities for marketing, sales, and regulatory affairs. Most recently, he served as the North American President for Inflammation and Immunology with responsibility for a portfolio spanning topical, small molecule oral, and biologic agents. Mr. Clavelli earned a Bachelor of Science in Physics from Fairfield University and an MBA from the Stern School of Business at New York University.

Per G Djupesland, MD, Ph.D. is the inventor of the patented, bi-directional nasal drug delivery technology and the main Founder of OptiNose. He has been Chief Scientific Officer (CSO) of OptiNose since 2000 and is in charge of the research activities at OptiNose, as well as, ongoing clinical studies designed to demonstrate the broad advantage of the bi-directional delivery system, including the recently completed Phase II studies in nasal polyposis, migraine and chronic rhinosinusitus. Per is an Otorhinolaryngologist (ORL) with a specialization in rhinology and has a Ph.D. in the field of nasal physiology and aerodynamics from the University of Oslo. He is world renowned expert, with over 25 years of clinical experience also spanning ORL, infectious diseases, epidemiology and surgery. He has been Clinical Research Fellow at the Hospital for Sick Children and Toronto General in Toronto, Canada, primarily studying the role of Nitric Oxide in the upper airways. His Ph.D. is focused on nasal physiology and aerodynamics in infants. Per is the author of over 80 articles in international medical journals, has lectured at numerous conferences and has filed 35 patent families/patent applications. He holds a MD from University of Oslo 1982, Diplom d´Úniversite´ (Master) from Paris, France and a Ph.D. from the University of Oslo

Peter became involved with OptiNose after accepting a request to join the Company’s Board in 2008. While serving in this role he became familiar with OptiNose’s unique drug delivery technology and was convinced of the significant potential of the product. In 2009 Mr. Miller, in coordination with the original founders, led a significant capital raise allowing OptiNose to move forward with clinical trials and the commercialization process. In 2010 he also accepted the role of CEO. Since then, Mr. Miller has overseen the relocation of the Company’s headquarters from Oslo, Norway, to Yardley, PA, and the expansion of the OptiNose team. He also remains a member of the Company’s Board of Directors. Mr. Miller was previously the Co-Founder, CEO and President of Take Care Health Systems a company which revolutionized healthcare by operating medical clinics inside Walgreen’s retail pharmacies. Along with co-founder Hal Rosenbluth, Peter helped create an industry which is seen as transformational innovation that is disrupting the U.S. Healthcare system. Peter, with co-founder, conceptualized the idea, hired a world-class management team, raised over $90 million in private equity/venture and sold their company to Walgreens in less than 4 years. Mr. Miller served as a vice president in the Walgreens Health and Wellness Division and remained CEO for Take Care Health Systems for 3 years after the sale to Walgreens and grew the clinic operation to over 400 clinics nationwide. Prior to founding Take Care Health Systems, Mr. Miller worked for health care industry leader Johnson & Johnson. Mr. Miller served in a variety of marketing and general management roles and was Worldwide President of Johnson & Johnson - Merck Consumer Pharmaceuticals, a $500 million dollar consumer pharmaceutical company and President of Janssen Pharmaceutica a $4 billion dollar pharmaceutical company. During his 15 year career with Johnson & Johnson, Mr. Miller also played an integral role in building multimillion and multibillion-dollar brands such as Tylenol, Motrin, Imodium, Pepcid, Duragesic, Risperdal and Aciphex. Mr. Miller earned an economics degree from Trinity College and an M.B.A. from the Kellogg School of Management at Northwestern University.