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Principal research scientist jobs in Indiana

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  • PhD-Level Computational Biologist - Design Data-Centric Benchmarks for AI Models

    Mercor

    Principal research scientist job in Terre Haute, IN

    Mercor is seeking computational biology experts to contribute to a unique project with a top-tier AI research organization. This short-term initiative challenges AI models with hidden-answer “mystery problems” grounded in real biological data. Experts will design, validate, and anonymize complex datasets to evaluate model reasoning capabilities, not lookup accuracy. This is a compelling opportunity for data-driven life scientists to shape next-generation AI evaluation benchmarks. **2\. Key Responsibilities** • Design biologically grounded problems with a single correct answer and ≥20 plausible distractors • Identify, download, and preprocess datasets from public repositories (e.g., GEO, SRA, NCBI) • Subsample and anonymize datasets to prevent metadata-based inference • Independently validate solutions through custom analysis pipelines and visualizations • Operate within technical constraints (e.g., file size, task time limits) **3\. Ideal Qualifications** • Hands-on experience analyzing sequencing or omics datasets (e.g., RNA-seq, WGS, mass spec) • Proficient with bioinformatics tools and formats (e.g., BLAST, samtools, DESeq2, FASTA/FASTQ/BAM) • Comfortable coding in Python, R, or bash, and working in Jupyter notebooks • Understanding of biological experiment design and lab-to-data nuances (e.g., batch effects) • Advanced degree (MS, PhD) or research background in computational biology, genomics, or bioinformatics **4\. More About the Opportunity** • Remote and asynchronous - set your own schedule • Expected commitment: 15-20 hours/week • Project duration: ~1 month • Potential for additional projects based on performance and interest **5\. Compensation & Contract Terms** • $65-85/hour depending on experience and geography • Paid weekly via Stripe Connect • Structured as a freelance contract - independent contractor status **6\. Application Process** • Submit your resume to get started • Qualified applicants will complete a short form assessing technical experience • Follow-up steps may include a sample task or review call • Responses typically within 3-5 business days **7\. About Mercor** • Mercor is a talent marketplace that connects top experts with leading AI labs and research organizations. • Our investors include Benchmark, General Catalyst, Adam D'Angelo, Larry Summers, and Jack Dorsey. • Thousands of professionals across domains like law, creatives, engineering, and research have joined Mercor to work on frontier projects shaping the next era of AI.
    $50k-82k yearly est. 2d ago
  • Principal Research Scientist/Research Advisor-Analytical Development

    Direct Staffing

    Principal research scientist job in Indianapolis, IN

    Responsibilities: The Principal Research Scientist/Research Advisor is responsible for analytical control strategies and for leading a team in the development, qualification/validation, and use of analytical, bioanalytical and characterization methods in support of biotherapeutic product development. • Ensure work and team activities are aligned with all relevant development quality, regulatory, HSE, GLP, and GMP requirements. • Serve as key analytical technical lead co-formulated drug products. • Responsible for development of analytical strategies for co-formulated drug products • Develop all or portions of analytical control strategies. • Development and verification/qualification/validation of analytical methods to support in-process, release, characterization analysis, and stability testing of active pharmaceutical ingredient and drug product. • Provide support for discovery, toxicology, cell culture, purification, formulation, and manufacturing. • Oversight for method transfers to development, QCL, or third party personnel. • Coaching, training, and administration of performance management to personnel (primarily, but not limited to, direct reports). Basic Qualifications • Ph.D. in analytical, biophysical, biochemistry, molecular/cell biology, or related field • Minimm of 8+ years experience in analytical development in industrial, pharmaceutical or biotech setting Additional Skills/Preferences • Experience with the supervision, mentoring and development of direct reports. • Demonstration of scientific leadership skills. • Effective oral and written communication skills. • Must be able to work productively in an interdisciplinary team environment. • Experience with the drug development process, including knowledge of regulatory compliance issues. • Fundamental knowledge of cGMP/GLP compliance requirements. CANDIDATE DETAILS 7+ to 10 years experience Minimum Education - Doctorate Degree . ADDITIONAL DETAILS Location: Indianapolis Industry: Job Category: Research & Development Hours Per Week: Visa Candidate Considered: No Qualifications Basic Qualifications • Ph.D. in analytical, biophysical, biochemistry, molecular/cell biology, or related field • Minimm of 8+ years experience in analytical development in industrial, pharmaceutical or biotech setting Additional Information All your information will be kept confidential according to EEO guidelines.
    $92k-135k yearly est. 10h ago
  • Principal Research Scientist

    Elanco 4.9company rating

    Principal research scientist job in Indianapolis, IN

    At Elanco (NYSE: ELAN) - it all starts with animals! As a global leader in animal health, we are dedicated to innovation and delivering products and services to prevent and treat disease in farm animals and pets. At Elanco, we are driven by our vision of Food and Companionship Enriching Life and our purpose - all to Go Beyond for Animals, Customers, Society and Our People. At Elanco, we pride ourselves on fostering a diverse and inclusive work environment. We believe that diversity is the driving force behind innovation, creativity, and overall business success. Here, you'll be part of a company that values and champions new ways of thinking, work with dynamic individuals, and acquire new skills and experiences that will propel your career to new heights. Making animals' lives better makes life better - join our team today! Job Title: Principal Research Scientist Location: 450 Elanco Circle, Indianapolis, Indiana, 46221. 25% domestic and international travel required for internal meetings for project planning and external meetings with external business partners for planning project implementations. Job Description: Your day-to-day will include: Responsible for conducting groundbreaking clinical research, all with the goal of developing novel, effective animal health products. Conceptualize, design, construct, and validate cell based in vivo and in vitro bioassays to screen activity and potency of Elanco's proprietary biotherapeutic and vaccine molecules. Conceptualize, design, construct, and validate cell based in vitro anti-drug antibody assays. Develop pharmacokinetic and pharmacodynamic biomarker assay reagents and assays, including providing subject matter expertise on the development of biopharmaceutical pre-clinical and clinical pharmacology flow schemes. Keep abreast of scientific developments in the field and integrate these novel developments into our research and development projects. Provide expertise and specialized knowledge in the evaluation of new platform technologies; determine which technologies and processes are best suited to meet Elanco's unique needs. Proactively search for novel technologies or product opportunities; use specialized knowledge to establish collaborations and research programs to deliver innovative technical solutions. Transfer knowledge and information from research to development, from development to registration, and from registration to launch, including the preparation of internal and external publications; ensure each step follows Elanco's company-wide standards and best practices. Analyze Elanco's current product offerings and identify areas for further research and development. Manage and oversee multiple research projects, ensuring that each project adheres to Elanco's standards, protocols, and best practices. Supervises 8 subordinates: Consultants and Senior Research Scientists. You have the following technical skills and qualifications: Requirement - Bachelor's degree in Veterinary Science, Veterinary Medicine, Animal Science, a related field, or a foreign equivalent plus 5 years of progressively responsible post-baccalaureate experience in job offered or any research scientist related job titles. Relevant experience - Applicants must possess at least 5 years of experience in the following: (1) clinical product development including experience with regulatory requirements for drug, vaccine, and parasitology; (2) conducting GCP and GLP studies; (3) obtaining approval for parasitology, small molecule drug, as well as vaccine projects; (4) team management; (5) Technical writing experience (writing papers for submission to regulatory agencies / publications); (6) developing clinical regulatory strategy; and (7) parasitology technologies for farm animals. 25% domestic and international travel required for internal meetings for project planning and external meetings with external business partners for planning project implementations. Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status
    $70k-93k yearly est. Auto-Apply 15d ago
  • Senior Applied AI Scientist

    Cisco Systems, Inc. 4.8company rating

    Principal research scientist job in Indianapolis, IN

    Meet the Team Splunk, a Cisco company, is building a safer, more resilient digital world with an end‑to‑end, full‑stack platform designed for hybrid, multi‑cloud environments. Join the Foundational Modeling team at Splunk, where we advance the state of AI for high‑volume, real‑time, multi‑modal machine‑generated data - including logs, time series, traces, and events. We combine deep AI research expertise with the scale and operational excellence of Splunk and Cisco's global engineering capabilities. Our work spans networking, security, observability, and customer experience - designing and deploying foundation models that enhance reliability, strengthen security, prevent downtime, and deliver predictive insights across Splunk Observability, Security, and Platform at enterprise scale. You'll be part of a culture that values technical excellence, impact‑driven innovation, and cross‑functional collaboration - all within a flexible, growth‑oriented environment. Your Impact * Lead the research, design, and deployment of large‑scale foundation models for machine‑generated data - primarily time series, augmented with logs traces, and events. * Optimize distributed training and inference pipelines to maximize accuracy, performance, and efficiency at scale. * Work closely with engineering, product, and data science to ensure solutions meet defined technical requirements and deliver tangible business impact. * Mentor team members and contribute directly to model architecture reviews, experimental design, and production rollout processes. * Stay current with AI/ML developments and integrate relevant advancements into ongoing projects and technical plans. Minimum Qualifications: * PhD in Computer Science, or related quantitative field, plus 1+ years of industry research experience. * Proven track record in at least one of the following areas: large language modeling for both structure and unstructured data, deep learning‑based time series modeling, advanced anomaly detection, and multi-modality modeling. * Solid proficiency in Python and deep learning frameworks (e.g., PyTorch, TensorFlow) * Experience translating research ideas into production systems. Preferred Qualifications: * Deep Learning for Time Series & Forecasting - Proven expertise designing and deploying architectures such as temporal transformers, temporal convolutional networks, and spatial‑temporal models. * Advanced Anomaly Detection - Experience creating robust, scalable approaches (statistical, deep learning, or hybrid) for high‑volume, real‑time time series data. * Multi‑Modal AI Modeling - Strong track record fusing logs, time series, traces, tabular data, and graphs for foundation models tackling complex operational insights. * Probabilistic Forecasting & Uncertainty Quantification - Skills in Bayesian deep learning and probabilistic models to capture and communicate predictive uncertainty. * Large‑Scale Training & Optimization - Experience optimizing model architectures, distributed training pipelines, and inference efficiency to minimize cost and latency while preserving accuracy. * MLOps & Continuous Learning - Fluency in automated retraining, drift detection, incremental updates, and production monitoring of ML models. * Strong Research Track Record - Publications in top AI/ML conferences or journals (e.g., NeurIPS, ICML, ICLR, AAAI, CVPR, ACL, KDD) demonstrating contributions to state‑of‑the‑art methods and real‑world applications. Why Cisco? At Cisco, we're revolutionizing how data and infrastructure connect and protect organizations in the AI era - and beyond. We've been innovating fearlessly for 40 years to create solutions that power how humans and technology work together across the physical and digital worlds. These solutions provide customers with unparalleled security, visibility, and insights across the entire digital footprint. Simply put - we power the future. Fueled by the depth and breadth of our technology, we experiment and create meaningful solutions. Add to that our worldwide network of doers and experts, and you'll see that the opportunities to grow and build are limitless. We work as a team, collaborating with empathy to make really big things happen on a global scale. Because our solutions are everywhere, our impact is everywhere. We are Cisco, and our power starts with you. Why Cisco? At Cisco, we're revolutionizing how data and infrastructure connect and protect organizations in the AI era - and beyond. We've been innovating fearlessly for 40 years to create solutions that power how humans and technology work together across the physical and digital worlds. These solutions provide customers with unparalleled security, visibility, and insights across the entire digital footprint. Fueled by the depth and breadth of our technology, we experiment and create meaningful solutions. Add to that our worldwide network of doers and experts, and you'll see that the opportunities to grow and build are limitless. We work as a team, collaborating with empathy to make really big things happen on a global scale. Because our solutions are everywhere, our impact is everywhere. We are Cisco, and our power starts with you. Message to applicants applying to work in the U.S. and/or Canada: The starting salary range posted for this position is $174,500.00 to $226,500.00 and reflects the projected salary range for new hires in this position in U.S. and/or Canada locations, not including incentive compensation*, equity, or benefits. Individual pay is determined by the candidate's hiring location, market conditions, job-related skillset, experience, qualifications, education, certifications, and/or training. The full salary range for certain locations is listed below. For locations not listed below, the recruiter can share more details about compensation for the role in your location during the hiring process. U.S. employees are offered benefits, subject to Cisco's plan eligibility rules, which include medical, dental and vision insurance, a 401(k) plan with a Cisco matching contribution, paid parental leave, short and long-term disability coverage, and basic life insurance. Please see the Cisco careers site to discover more benefits and perks. Employees may be eligible to receive grants of Cisco restricted stock units, which vest following continued employment with Cisco for defined periods of time. U.S. employees are eligible for paid time away as described below, subject to Cisco's policies: * 10 paid holidays per full calendar year, plus 1 floating holiday for non-exempt employees * 1 paid day off for employee's birthday, paid year-end holiday shutdown, and 4 paid days off for personal wellness determined by Cisco * Non-exempt employees receive 16 days of paid vacation time per full calendar year, accrued at rate of 4.92 hours per pay period for full-time employees * Exempt employees participate in Cisco's flexible vacation time off program, which has no defined limit on how much vacation time eligible employees may use (subject to availability and some business limitations) * 80 hours of sick time off provided on hire date and each January 1st thereafter, and up to 80 hours of unused sick time carried forward from one calendar year to the next * Additional paid time away may be requested to deal with critical or emergency issues for family members * Optional 10 paid days per full calendar year to volunteer For non-sales roles, employees are also eligible to earn annual bonuses subject to Cisco's policies. Employees on sales plans earn performance-based incentive pay on top of their base salary, which is split between quota and non-quota components, subject to the applicable Cisco plan. For quota-based incentive pay, Cisco typically pays as follows: * .75% of incentive target for each 1% of revenue attainment up to 50% of quota; * 1.5% of incentive target for each 1% of attainment between 50% and 75%; * 1% of incentive target for each 1% of attainment between 75% and 100%; and * Once performance exceeds 100% attainment, incentive rates are at or above 1% for each 1% of attainment with no cap on incentive compensation. For non-quota-based sales performance elements such as strategic sales objectives, Cisco may pay 0% up to 125% of target. Cisco sales plans do not have a minimum threshold of performance for sales incentive compensation to be paid. The applicable full salary ranges for this position, by specific state, are listed below: New York City Metro Area: $199,700.00 - $292,800.00 Non-Metro New York state & Washington state: $174,500.00 - $260,500.00 * For quota-based sales roles on Cisco's sales plan, the ranges provided in this posting include base pay and sales target incentive compensation combined. Employees in Illinois, whether exempt or non-exempt, will participate in a unique time off program to meet local requirements.
    $199.7k-292.8k yearly 9d ago
  • Research Scientist - CTRL Labs

    Meta 4.8company rating

    Principal research scientist job in Indianapolis, IN

    Reality Labs at Meta is seeking Research Scientists with experience in product-focused machine learning and signal processing research to advance our pioneering work in neuromotor interfaces, which has grown out of the acquisition of CTRL-labs. We're building a practical interface drawing on the rich neuromotor signals that can be measured non-invasively via surface electromyography (EMG) with single motor neuron resolution. This technology could become one of the main pillars for interaction with virtual and augmented worlds.We are a multi-disciplinary team of researchers investigating the nature of human neuromotor signals, developing novel signal processing and machine learning methods to infer a user's intent, and creating novel interaction techniques and user experiences. Help us unleash human potential by removing the bottlenecks between user intent and action. **Required Skills:** Research Scientist - CTRL Labs Responsibilities: 1. Research and develop Deep Learning or other computational models 2. Design methods, tools and infrastructure to analyze and leverage rich multimodal data sets 3. Set technical direction for a project of 2-3 researchers and engineers 4. Help transition and deliver our work from research into product 5. Adapt standard machine learning methods to best leverage modern parallel environments (e.g. distributed clusters, multicore SMP, and GPU) **Minimum Qualifications:** Minimum Qualifications: 6. Bachelor's degree in Computer Science, Computer Engineering, relevant technical field, or equivalent practical experience 7. Ph.D. degree in Computer Science and Engineering, Electrical Engineering, Statistics/Mathematics 8. Experience with developing machine learning models at scale from inception to business impact 9. Programming experience in Python and hands-on experience with frameworks such as PyTorch 10. Exposure to architectural patterns of large scale software applications 11. Must obtain work authorization in the country of employment at the time of hire, and maintain ongoing work authorization during employment **Preferred Qualifications:** Preferred Qualifications: 12. Proven track record of achieving significant results as demonstrated by grants, fellowships, patents, as well as first-authored publications at peer-reviewed AI conferences (e.g. NeurIPS, CVPR, ICML, ICLR, ICCV, ACL, and ICASSP) 13. Demonstrated software engineer experience via an internship, work experience, coding competitions, or widely used contributions in open source repositories (e.g. GitHub) 14. Experience bringing machine learning-based products from research to production **Public Compensation:** $177,000/year to $251,000/year + benefits **Industry:** Internet **Equal Opportunity:** Meta is proud to be an Equal Employment Opportunity and Affirmative Action employer. We do not discriminate based upon race, religion, color, national origin, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender, gender identity, gender expression, transgender status, sexual stereotypes, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics. We also consider qualified applicants with criminal histories, consistent with applicable federal, state and local law. Meta participates in the E-Verify program in certain locations, as required by law. Please note that Meta may leverage artificial intelligence and machine learning technologies in connection with applications for employment. Meta is committed to providing reasonable accommodations for candidates with disabilities in our recruiting process. If you need any assistance or accommodations due to a disability, please let us know at accommodations-ext@fb.com.
    $177k-251k yearly 60d+ ago
  • Senior Principal Scientist, Biologics - Translational Medicine

    Amer 4.2company rating

    Principal research scientist job in Fishers, IN

    See Yourself at Telix This role provides technical and analytical expertise for translational to early phase biologics process development and manufacturing activities ensuring developability and manufacturability assessments and drug substance intermediates are sufficiently developed to meet program objectives, safety standards, regulatory expectations, and quality compliance. This role is responsible for managing projects in multiple technology areas (e.g. cell banking, bioprocess/bioconjugation, analytical, formulation, and/or other) at external partners, as well as contributing to internal cross-functional collaborations to develop and support future preclinical activities, process development, and/or clinical manufacturing. The Senior Principal Scientist, Biologics - Translational Medicine is a subject matter expert who acts as the Biologics lead for one or more therapeutic programs and should be comfortable communicating with cross-functional teams including governance forums with senior leadership team members in formal settings and third-party meetings, be an expert in one or more technical areas (e.g. cell banking, bioprocess/bioconjugation, analytical, formulation, and/or other), and manage their own workload to complete assignments autonomously with occasional feedback from senior-level colleagues and/or their manager for more complicated topics. Key Accountabilities: Oversee development projects for multiple technology areas (e.g. cell banking, bioprocess/bioconjugation, analytical, formulation, and/or other) ensuring the appropriate developability and manufacturability assessments to enable future process knowledge, technology transfer, analytical method transfer, design space definition, to produce preclinical and/or clinical drug substance intermediates. Oversee external manufacturing projects to deliver SOPs, batch records, protocols, and reports for multiple technology areas (e.g. cell banking, bioprocess/bioconjugation, analytical, formulation, and/or other) to produce preclinical and/or clinical drug substance intermediates which may include monoclonal antibody or other molecule type bulk, bioconjugate bulk, and vial components of such. Authors and/or reviews source documents and CMC content related to several technology areas (e.g. cell banking, bioprocess/bioconjugation, analytical, formulation, or other) to support early IB, IMPD, and similar regulatory agency applications, especially in areas requiring more sophisticated acumen such as risk-based approach justifications. Ensures appropriate document curation, storage, and compliance through document creation/review/approval within a Quality system. Leads collaborations with external partners to develop selection criteria, assess capabilities, coordinate activities, plan process technology transfer/analytical method transfer, troubleshoot and analyze operational performance, conduct risk assessments, and manage timely deliverables. Mentors other level Scientists on both technical topics as well as Telix values. Education and Experience: Science or engineering degree with minimum relevant experience as applicable: BS with 14 years of experience, MS with 12 years of experience, PhD with 11 years of experience. Minimum 10 years of experience in translational to early phase GMP, quality management system, and CMC compliance and regulation. Demonstrated understanding and application of project management principles and tools. Ability to work in cross-functional, virtual teams. Travel expectation: 10 - 25% for key in-person meetings, partner site visits, and SME/technical person-in-plant assignments. Key Capabilities: Inclusive mindset: Demonstrate an understanding and appreciation for diversity, and actively work to create an inclusive environment where everyone feels valued and respected Creativity and innovation: Possess a willingness to think outside the box and come up with unique and creative solutions to challenges Commitment to excellence: Take pride in your work and consistently strive for excellence in everything you do Results-oriented: Driven to achieve goals and objectives, with a strong focus on delivering measurable results Ethical behavior: Act with integrity and demonstrate a commitment to ethical behavior in all interactions with colleagues and stakeholders Adaptability: Comfortable working in a dynamic environment, able to adjust to changing priorities, and willing to take on new challenges Strong communication skills: Able to communicate effectively with colleagues and stakeholders at all levels, using clear and concise language Collaboration: Work effectively as part of a team, actively sharing knowledge and expertise to achieve common goals Resilience: Demonstrate the ability to bounce back from setbacks and persevere in the face of challenges Continuous learning: Show a commitment to ongoing learning and professional development, continually seeking out opportunities to expand your knowledge and skills
    $103k-147k yearly est. Auto-Apply 13d ago
  • Senior or Principal Scientist - Beverage & Flavor Applications

    Vibrant Ingredients

    Principal research scientist job in Indianapolis, IN

    Founded in 1954, Vibrant Ingredients is committed to providing innovative clean label solutions that naturally provide exceptional food protection, flavor, color and texture for a variety of applications, including processed and cured meat, beverages, plant-based alternatives, health and wellness, culinary, and pet nutrition. Vibrant Ingredients believes in improving the food and beverages we eat and drink with ingredients from nature that work. About the role: We are a trusted partner to our customers when it comes to innovation and an industry leader in clean label ingredients, we are a true partner. We collaborate with our customers in ways that respect people and the environment. A commitment to Real. Simple. Better™ drives our innovation team to discover new, on trend solutions. As a Senior or Principal Scientist - Beverage & Flavor Applications, you will lead the development of innovative tea and beverage systems using cutting-edge flavor and botanical technologies. This is a visible, customer-facing role where you'll manage end-to-end project work-from benchtop formulation to commercialization-and collaborate cross-functionally with R&D, Sales, Marketing, and Operations to deliver impactful solutions. How will you contribute: To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable accommodation may be made to enable qualified individuals with disabilities to perform essential job functions. Essential job functions and duties include, but are not limited to: Lead formulation and development of beverage applications, especially tea, botanicals, functional drinks, flavored waters, syrups, and dairy alternatives. Develop and optimize extractions from botanicals, teas, and other plant-based materials to deliver targeted flavor, functionality, and performance. Design and run benchtop and pilot-scale trials using technologies such as MicroThermics and other beverage processing systems. Translate customer briefs into innovative, scalable beverage and flavor systems. Conduct sensory and analytical evaluations to ensure quality, taste, and consistency. Act as a technical expert during customer presentations, demo sessions, and plant trials. Work closely with internal stakeholders to ensure seamless handoff to commercialization and production. Stay informed on market trends, customer strategies, competitive landscapes, and new ingredient technologies. Support ongoing improvement of lab processes, documentation, and sample inventory systems. Minimum Requirements/Qualifications: Bachelor's degree in Food Science, Chemistry, Chemical Engineering, or related field. (Master's/PhD preferred for Principal Scientist level) 10+ years of beverage formulation and product development experience; at least 5 years with tea and botanical applications. Deep expertise in functional beverages and flavor system development. Experience with pilot-scale processing, sensory analysis, and customer interaction. Demonstrated ability to manage complex projects and deliver timely results. Work Environment: May involve exposure to allergens such as Soy, Wheat, Fish, Shellfish, Milk, Egg, Tree Nuts and Sesame. What Florida Food Products can offer you: Generous time off for vacations Paid Holidays 401(k) with company match Tuition reimbursement Medical/Dental/Vision Health & Wellness programs More about us: Vibrant Ingredients, headquartered in Lake Mary, FL, is one of the world's leading independent providers of natural ingredients. With a legacy spanning over 70 years, we deliver a diverse portfolio of clean label ingredients and innovative system solutions to the food and beverage industry. Our commitment to quality and performance is reflected in our American-made products, which enhance both taste and functionality. Backed by advanced manufacturing capabilities, we specialize in fermentation, patented cold brew extraction, custom flavor development, and a range of drying and blending technologies. Operating from four state-of-the-art facilities strategically located across the U.S., we ensure the accessibility of real, high-quality ingredients-helping our customers create better-for-you food and beverage for consumers. "Improving the food and beverages consumed by providing real ingredients from nature that work." This position is currently classified as on-site for our Indianapolis Facility. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Holidays, Vacation, Tuition Reimbursement Program. The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience. The Company reserves the right to modify, update, change and/or make corrections to this job description, at the sole discretion of senior management, at any time during the employee's employment term, at the sole discretion of management. EEO Statement Vibrant Ingredients is an equal opportunity employer committed to employing a diverse workforce and providing accommodations for people with disabilities in all parts of the hiring process as required under its Employment Accommodation Policy. Vibrant Ingredients will work with applicants to meet accommodation needs that are made known to Vibrant Ingredients in advance. **Please no external recruiters**
    $100k-146k yearly est. 5d ago
  • Research Scientist-Health Services Research

    Elevance Health

    Principal research scientist job in Indianapolis, IN

    Locations: This role requires associates to be in-office 1-2 days per week, fostering collaboration and connectivity, while providing flexibility to support productivity and work-life balance. This approach combines structured office engagement with the autonomy of virtual work, promoting a dynamic and adaptable workplace. Alternate locations may be considered if candidates reside within a commuting distance from an office Please note that per our policy on hybrid/virtual work, candidates not within a reasonable commuting distance from the posting location(s) will not be considered for employment, unless an accommodation is granted as required by law. PLEASE NOTE: This position is not eligible for current or future VISA sponsorship. The Research Scientist-Health Services Research is responsible for Carelon Research research line of business; specific projects ranging from retrospective to large-scale, prospective studies in areas including population health, health economics, clinical effectiveness (drug, procedures, vaccine, and medical device), and implementation sciences. This role will conduct research studies for Elevance Health, Carelon, and external clients. How you will make an Impact: * Leads high quality research project proposal development from early conceptual stages for external and internal submissions. * Provides scientific rigorous input in the design and development of the research studies to fulfill study objectives. * Executes statistical analyses plans independently with effective problem solving and decision making as principal investigator across a broad program of studies related to a therapeutic area /healthcare intervention and/or external collaborator. * Collaborates with project team members to implement the study design and statistical analyses plans utilizing advanced statistical techniques such as propensity score modeling, GEE (generalized estimate equation) difference-in-difference, and graduate-level statistics in performing research study design and analysis. * Conducts review of administrative claims, electronic medical records, and survey and clinical data and statistical output and review of statistical output to ensure the superior quality of research activities and client deliverables. . * Summarizes key findings and generates value messages for incorporation into project deliverables, publications, and presentations. * Prepares study reports and manuscripts for submissions to peer-review journals demonstrating subject matter expertise. * Performs key project functions with minimal oversight. * Responsible for the final quality and accuracy of study deliverables, presentation of study deliverables and facilitation of the collaboration among project team members towards development. * Manage relationships with study champions/clients, communicates scientific decisions, and presents key study insights to the champions, including Elevance Health senior leadership team, internal decision makers, and other external stakeholders/clients. Minimum Requirements: Requires a MS in health sciences or related advanced degree, or clinical degree such as PharmD, or MD, combined with Master level degree and a minimum of 5 years of experience in health service research, biostatistics, epidemiology, health policy, economics or related field; or any combination of education and experience which would provide an equivalent background. Preferred Skills, Experiences and Competencies: * Ph.D. or MD strongly preferred. * Postgraduate or post-doctoral training or relevant experience in conducting observational and/or prospective research studies. * Understanding of the U.S. health care system, population health and implementation sciences strongly preferred. * Successful experience with research grants/funding applications is strongly preferred. * Proficient in statistical software, including SAS, STATA, R, and/or Python strongly preferred. * Proficient in data management tools, including SQL strongly preferred. Job Level: Non-Management Exempt Workshift: 1st Shift (United States of America) Job Family: RDA > Research Data Please be advised that Elevance Health only accepts resumes for compensation from agencies that have a signed agreement with Elevance Health. Any unsolicited resumes, including those submitted to hiring managers, are deemed to be the property of Elevance Health. Who We Are Elevance Health is a health company dedicated to improving lives and communities - and making healthcare simpler. We are a Fortune 25 company with a longstanding history in the healthcare industry, looking for leaders at all levels of the organization who are passionate about making an impact on our members and the communities we serve. How We Work At Elevance Health, we are creating a culture that is designed to advance our strategy but will also lead to personal and professional growth for our associates. Our values and behaviors are the root of our culture. They are how we achieve our strategy, power our business outcomes and drive our shared success - for our consumers, our associates, our communities and our business. We offer a range of market-competitive total rewards that include merit increases, paid holidays, Paid Time Off, and incentive bonus programs (unless covered by a collective bargaining agreement), medical, dental, vision, short and long term disability benefits, 401(k) +match, stock purchase plan, life insurance, wellness programs and financial education resources, to name a few. Elevance Health operates in a Hybrid Workforce Strategy. Unless specified as primarily virtual by the hiring manager, associates are required to work at an Elevance Health location at least once per week, and potentially several times per week. Specific requirements and expectations for time onsite will be discussed as part of the hiring process. The health of our associates and communities is a top priority for Elevance Health. We require all new candidates in certain patient/member-facing roles to become vaccinated against COVID-19 and Influenza. If you are not vaccinated, your offer will be rescinded unless you provide an acceptable explanation. Elevance Health will also follow all relevant federal, state and local laws. Elevance Health is an Equal Employment Opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, citizenship status, color, creed, disability, ethnicity, genetic information, gender (including gender identity and gender expression), marital status, national origin, race, religion, sex, sexual orientation, veteran status or any other status or condition protected by applicable federal, state, or local laws. Applicants who require accommodation to participate in the job application process may contact ******************************************** for assistance. Qualified applicants with arrest or conviction records will be considered for employment in accordance with all federal, state, and local laws, including, but not limited to, the Los Angeles County Fair Chance Ordinance and the California Fair Chance Act.
    $79k-120k yearly est. 12d ago
  • Staff Applied Scientist (Causal Inference)

    Coinbase 4.2company rating

    Principal research scientist job in Indianapolis, IN

    Ready to be pushed beyond what you think you're capable of? At Coinbase, our mission is to increase economic freedom in the world. It's a massive, ambitious opportunity that demands the best of us, every day, as we build the emerging onchain platform - and with it, the future global financial system. To achieve our mission, we're seeking a very specific candidate. We want someone who is passionate about our mission and who believes in the power of crypto and blockchain technology to update the financial system. We want someone who is eager to leave their mark on the world, who relishes the pressure and privilege of working with high caliber colleagues, and who actively seeks feedback to keep leveling up. We want someone who will run towards, not away from, solving the company's hardest problems. Our ******************************** is intense and isn't for everyone. But if you want to build the future alongside others who excel in their disciplines and expect the same from you, there's no better place to be. While many roles at Coinbase are remote-first, we are not remote-only. In-person participation is required throughout the year. Team and company-wide offsites are held multiple times annually to foster collaboration, connection, and alignment. Attendance is expected and fully supported. As an Applied Scientist sitting within our Data Science organization, you will be responsible for building cutting edge models to navigate critical tradeoffs to drive business value. *What You'll Be Doing (ie. Job Duties)* * Develop and* deploy robust causal inference models* to quantify the holistic business impact of new product launches (e.g. PSM, Double ML) * Act as a leader to establish *standards for measurement* for new product and feature launches * Provide *technical mentorship* for other members of the data science organization * Act as a *thought partner* for senior leadership to help guide our product development process *What We Look For In You:* * PhD or Master's degree in a quantitative field such as Economics, Statistics with 8+ years of distinguished industry experience * Strong proficiency in SQL, Python, R, or other programming languages used for data analysis and statistical modeling * Deep theoretical and applied expertise in a wide range of quasi-experimental methods * A track record of influencing business and product strategy through data-driven, causal insights, and a proven ability to translate complex technical concepts to non-technical stakeholders. * Demonstration of our core cultural values: clear communication, positive energy, continuous learning, and efficient execution. *Nice to Haves:* * Experience in the fintech or crypto industries. * Specific experience working pricing models, marketing attribution, or customer LTV modeling. * Familiarity with the unique opportunities and challenges of crypto businesses and blockchain data. Disclaimer: Applying for a specific role does not guarantee consideration for that exact position. Leveling and team matching are assessed throughout the interview process. PID: G2462 \#LI-Remote *Pay Transparency Notice:* Depending on your work location, the target annual salary for this position can range as detailed below. Full time offers from Coinbase also include bonus eligibility + equity eligibility**+ benefits (including medical, dental, vision and 401(k)). Pay Range: $207,485-$275,000 USD Please be advised that each candidate may submit a maximum of four applications within any 30-day period. We encourage you to carefully evaluate how your skills and interests align with Coinbase's roles before applying. Commitment to Equal Opportunity Coinbase is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, sex, gender expression or identity, sexual orientation or any other basis protected by applicable law. Coinbase will also consider for employment qualified applicants with criminal histories in a manner consistent with applicable federal, state and local law. For US applicants, you may view the *********************************************** in certain locations, as required by law. Coinbase is also committed to providing reasonable accommodations to individuals with disabilities. If you need a reasonable accommodation because of a disability for any part of the employment process, please contact us at accommodations*********************************** *Global Data Privacy Notice for Job Candidates and Applicants* Depending on your location, the General Data Protection Regulation (GDPR) and California Consumer Privacy Act (CCPA) may regulate the way we manage the data of job applicants. Our full notice outlining how data will be processed as part of the application procedure for applicable locations is available ********************************************************** By submitting your application, you are agreeing to our use and processing of your data as required. *AI Disclosure* For select roles, Coinbase is piloting an AI tool based on machine learning technologies to conduct initial screening interviews to qualified applicants. The tool simulates realistic interview scenarios and engages in dynamic conversation. A human recruiter will review your interview responses, provided in the form of a voice recording and/or transcript, to assess them against the qualifications and characteristics outlined in the job description. For select roles, Coinbase is also piloting an AI interview intelligence platform to transcribe and summarize interview notes, allowing our interviewers to fully focus on you as the candidate. *The above pilots are for testing purposes and Coinbase will not use AI to make decisions impacting employment*. To request a reasonable accommodation due to disability, please contact accommodations[at]coinbase.com
    $207.5k-275k yearly 60d+ ago
  • Research Scientist

    Indiana University Academic Positions 4.6company rating

    Principal research scientist job in Bloomington, IN

    Research Scientist for Indiana University Cognitive Development Lab The Cognitive Development Lab at Indiana University-Bloomington (PI: Linda Smith) invites applications for a Research Scientist to assist in the creation and analysis of a shareable data set (of already collected data) from nearly 10,000 children ages 15 to 36 months. There is both a scientific premise and a methodological premise underlying the project. The scientific premise is that developmental changes in visual cognition and early vocabulary development interact, with advances in visual cognition supporting early language learning and also being changed by language learning. The literature indicates multiple causal factors and inflection points that can disrupt this early stage of vocabulary growth- limitations in audition, or vision, in phonological representations, in visual attention, in the composition of early vocabularies, and in the quality and composition of language input. The methodological premise concerns how to leverage all the data that has been already collected on these issues; experiments with many of the same overlapping measures designed with specific hypotheses in mind. The methodological premise for this project is that given some overlapping measures in the individual data sets and through the use of advanced analytic tools including machine learning and graph theoretics, one can discover multiple developmental pathways in cross-sectional data and the factors that underlie the trajectories of those pathways. These inferred pathways then can be empirically tested in longitudinal studies. Strong applicants will have quantitative and computational training as well as experience in behavioral science, ideally in development, language, or visual cognition. The successful applicant will have: Excellent research track record. Excellent programming skills. Experience in computational and statistical methods and analyses including either graph theoretic of machine learning approaches (or both). A track record of initiative, ability to lead a team (of undergraduates/masters students) and effective teamwork. Fit of this project with their own career trajectory/goals PhD in Psychology or related field How to Apply: Interested candidates should apply at ********************************************** by submitting a cover letter describing your interests and prior experiences, CV, and contact information for three references. Applications will be accepted on an ongoing basis until the position is filled. Application review will start December 1, 2024. Anticipated start date is February 1, 2025. Start date is negotiable. Questions regarding the position or application process can be directed to: Dr. Linda Smith ( ************* ).
    $65k-89k yearly est. Easy Apply 60d+ ago
  • Sr. Formulation Scientist

    Agxelerators, Inc.

    Principal research scientist job in West Lafayette, IN

    Senior Formulation Scientist (Full-time) Join Us in Revolutionizing Agriculture! Are you ready to be at the forefront of agricultural innovation? AgXelerators Inc. is a bold, fast-moving start-up on a mission to transform crop protection, crop health, soil regeneration, and sustainable agriculture. Were not just developing products - were redefining whats possible. Our team thrives on creativity, risk-taking, and an entrepreneurial mindset, pushing the boundaries of science to create cutting-edge solutions for the future of farming. We are looking for a Formulation Scientist to help shape the future of agriculture. Based at the Purdue Technology Center in West Lafayette, Indiana, this role is a rare opportunity to work alongside some of the greatest minds in formulation science. If youre passionate about innovation and want to see your work make a real impact, this is your chance to join a high-energy start-up where your contributions will directly drive our success. Key Responsibilities: In consultation with company experts, lead the formulation development efforts of new active ingredients, including both biologicals (micro-organisms, proteins, peptides, plant extracts, viruses) and chemistry (naturally-derived or synthetic). Collaborate with our customers to ensure alignment between formulation development, regulatory requirements, and commercial objectives. Design and optimize formulation compositions to improve product performance, stability, and efficacy. Conduct laboratory experiments and tests to evaluate the physical and chemical properties of formulations. Stay abreast of industry trends, emerging technologies, and regulatory developments in agricultural formulations and actively contribute to innovative ideas and new approaches. Follow established protocols and standard operating procedures (SOPs) for safe and efficient laboratory practices. Record and document all experimental information and organize, analyze, summarize, and report the final results. Communicate effectively with other team members and our customers. Present experimental results and progress in group discussions and project updates. Provide technical guidance and mentorship to junior team members as needed. Qualifications: PhD or Master's degree in chemistry, chemical engineering, material science or related field. 5+ years of experience in agricultural formulation development (industry or research). Proven success in bringing innovative agricultural products to market. Strong understanding of regulatory frameworks for agricultural formulations. A curious, hands-on scientist eager to push boundaries and explore new frontiers. Excellent communicator who thrives in a collaborative, fast-paced environment. Excellent problem-solving skills and the ability to work independently as well as part of a team. Entrepreneurial spirit with a passion for solving big problems and taking bold risks. Enthusiastic about the opportunity to contribute to the growth of a small start-up team. Why Join Us? Game-changing impact Play a key role in transforming the future of agriculture. Equity ownership Share in the companys growth and success. Dynamic start-up environment Work on exciting, high-stakes projects with top industry experts. Flexibility & autonomy A work environment that values creativity, adaptability, and independence. Competitive benefits package Designed to reward your talent and expertise. If youre excited about making a real difference in sustainable agriculture and thrive in a start-up environment where innovation is at the core, wed love to hear from you!
    $88k-126k yearly est. 13d ago
  • Advisor Research Scientist (Purification) - ADN RAMP Team

    Eli Lilly and Company 4.6company rating

    Principal research scientist job in Indianapolis, IN

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. Position Brand Description: The Lilly API (Active Pharmaceutical Ingredient) Dry Product Network is rapidly expanding to meet the demand for new products, and several new greenfield sites are under construction and will be starting up in the coming years. The new sites are staffed based on full-scale, steady state production, however additional surge capacity is needed to support the site start-up and help quickly ramp to full capacity rates. The ADN RAMP (Rapid Access to Medicines for Patients) team is a cross-functional team that will bring deep manufacturing expertise and will support each site start-up through Operational Excellence knowledge, rapid troubleshooting and problem-solving capability, and surge capacity resources. This unique opportunity will enable team members to work at our new sites, create a larger Lilly network, build and use their technical skills, and learn leadership skills through formal training and on-the-ground experiences. This team will also build strategies to help other new Lilly sites to start up faster, helping to accelerate Lilly's vision of serving more patients. Success in this challenging role will require supporting the sites through startup through direct technical execution, coaching next employees, and strong collaboration - and development of the local technical and operational teams to be ready for full operation. The team will directly report through their respective functions but will be coordinated by the Ramp Team Sr. Director. Key Responsibilities: Lead the successful transfer of new molecules into production at Lilly Sites Leverage internal and external expertise to improve existing production processes focused on purification of peptides Establish a world class methodology to ensure new manufacturing processes are robust, cost effective and can be transitioned safely and rapidly into production Maintain a thorough understanding of the state of the art of manufacturing and regulatory requirements and build these into our processes Develop strong working relationships with both R&D and plant sites to ensure success Serves as a member of multidisciplinary product development teams responsible for the commercial scale development of new processes. He/she typically directs the laboratory activities and development of one or more junior staff members Participate in the Science Lead Team- part of scientific governance/oversight for Lilly sites. Provide technical oversight to the Post Launch Optimization Team (PLOT) and other relevant TS/MS technical projects. Be the technical steward on all products they are accountable for. Define and lead TS/MS technical projects (experimental, modelling and/or production data analysis) to improve process control, yield, purity and/or productivity. The Research Scientist/Senior Research Scientist should also have a proven track record in the following areas. Demonstrated ability to commercialize and solve manufacturing problems. Hands on experience supporting production at different scales from both a commercialization and supply perspective. Proven track record of working with diverse groups across the value chain and in multiple locations Understanding the interaction of bulk drug substance and drug product formulation interaction of equipment set(s) with process (drug substance and drug product) Significant experience with registration, including authoring of technical reports, Development History Report, regulatory responses, or direct interactions with regulatory agencies. Basic Requirements: BSc/MSc/PhD in Chemistry/Biochemistry or related science discipline. BSc requires 10+ years of industrial experience. MSc/PhD requires 5+ years of industrial experience. Deep technical interest and understanding in manufacturing operational excellence principles. Additional Skills/Preferences: Excellent verbal and written communications skills. Strong analytical and problem-solving skills. Collaborative skills with operations, automation, and other process team members. Ability to coach others. Ability to influence without authority. Ability to clarify and simplify complex issues. Strong trust building with peers and leaders. Willing to work off-shift hours as needed to support project milestones and training of new employees. Other Information: The ADN RAMP team will support multiple new API/Dry Products sites in various locations (US and OUS). Significant travel may be required to current startup sites in order to meet business needs, along with potential short-term assignments across the network (can include international relocations). Candidates must be mobile and flexible. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (******************************************************** for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $114,000 - $198,000 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly
    $114k-198k yearly Auto-Apply 60d+ ago
  • Sr Scientist - Radiopharmaceutical Development & CMC - Indianapolis,IN

    Msccn

    Principal research scientist job in Indianapolis, IN

    ATTENTION MILITARY AFFILIATED JOB SEEKERS - Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spouses, Wounded Warriors, and their Caregivers . If you have the required skill set, education requirements, and experience, please click the submit button and follow the next steps. Unless specifically stated otherwise, this role is "On-Site" at the location detailed in the job post. Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals. Summary We are seeking a highly motivated Sr. Scientist to lead the development and optimization of radiopharmaceutical drug products and radioisotopes. This position plays a pivotal role in driving preclinical development of innovative drug products aimed at treating various cancers. The successful candidate will contribute to shaping and advancing our Chemistry, Manufacturing, and Controls (CMC) strategy Job Responsibilities Essential duties and responsibilities include the following. Other duties may be assigned. ·Design, plan and execute scientific experiments for pre-clinical development of radiopharmaceuticals. ·Drive CMC process development and optimization for clinical drug products, including formulation lock and robust process definition, ensuring scalability and compliance with regulatory standards ·Design, plan and execute scientific experiments for scale up and automation of drug products and API manufacturing processes. ·Interpret complex experimental data, draw scientifically rigorous conclusions, and communicate findings in technical reports, regulatory documentation, and presentations for internal and external stakeholders ·Author technical reports and source documents to support regulatory filing. ·Author CMC sections for IND/NDA for FDA submissions, and support regulatory filing in other jurisdictions, e.g. EMA, Health Canada, etc. ·Support technology transfer of drug products and API from preclinical stage to clinical manufacturing. ·Collaborate cross-functionally with Regulatory, Quality, Supply Chain, Clinical, and R&D teams to ensure alignment with corporate goals ·Manage and prioritize research projects, oversee third-party vendors, and mentor junior scientists and associates ·Provide support for commercialization of radiopharmaceuticals ·Up to 20% of travel required Additional Qualifications/Responsibilities Education and Experience ·Ph.D., M.S., or B.S. in Chemistry, Chemical Engineering, Pharmaceutical Sciences, or a related field, with requisite industry experience. ·5+ years of experience in drug development, manufacturing, CMC or related fields in a pharmaceutical industry, preferably radiopharmaceuticals. Skills and Qualifications ·Strong understanding of GMP, FDA/EMA regulations, and ICH guidelines. ·Strong problem-solving abilities and the ability to manage multiple projects in a fast-paced environment. ·Excellent project management and cross-functional collaboration skills. ·Excellent technical writing skills. Physical Demands While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 15 pounds. Specific vision abilities required by this job include close vision and distance vision. This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials. Work Environment The noise level in the work environment is usually moderate. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: Indianapolis - RayzeBio - IN: $107,904 - $130,754 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience.
    $107.9k-130.8k yearly 28d ago
  • Sr Scientist - Radiopharmaceutical Development & CMC

    Bristol-Myers Squibb 4.6company rating

    Principal research scientist job in Indiana

    Working with Us Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us. RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals. Summary We are seeking a highly motivated Sr. Scientist to lead the development and optimization of radiopharmaceutical drug products and radioisotopes. This position plays a pivotal role in driving preclinical development of innovative drug products aimed at treating various cancers. The successful candidate will contribute to shaping and advancing our Chemistry, Manufacturing, and Controls (CMC) strategy Job Responsibilities Essential duties and responsibilities include the following. Other duties may be assigned. ·Design, plan and execute scientific experiments for pre-clinical development of radiopharmaceuticals. ·Drive CMC process development and optimization for clinical drug products, including formulation lock and robust process definition, ensuring scalability and compliance with regulatory standards ·Design, plan and execute scientific experiments for scale up and automation of drug products and API manufacturing processes. ·Interpret complex experimental data, draw scientifically rigorous conclusions, and communicate findings in technical reports, regulatory documentation, and presentations for internal and external stakeholders ·Author technical reports and source documents to support regulatory filing. ·Author CMC sections for IND/NDA for FDA submissions, and support regulatory filing in other jurisdictions, e.g. EMA, Health Canada, etc. ·Support technology transfer of drug products and API from preclinical stage to clinical manufacturing. ·Collaborate cross-functionally with Regulatory, Quality, Supply Chain, Clinical, and R&D teams to ensure alignment with corporate goals ·Manage and prioritize research projects, oversee third-party vendors, and mentor junior scientists and associates ·Provide support for commercialization of radiopharmaceuticals ·Up to 20% of travel required Education and Experience ·Ph.D., M.S., or B.S. in Chemistry, Chemical Engineering, Pharmaceutical Sciences, or a related field, with requisite industry experience. ·5+ years of experience in drug development, manufacturing, CMC or related fields in a pharmaceutical industry, preferably radiopharmaceuticals. Skills and Qualifications ·Strong understanding of GMP, FDA/EMA regulations, and ICH guidelines. ·Strong problem-solving abilities and the ability to manage multiple projects in a fast-paced environment. ·Excellent project management and cross-functional collaboration skills. ·Excellent technical writing skills. Physical Demands While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 15 pounds. Specific vision abilities required by this job include close vision and distance vision. This is a position that requires working in a laboratory environment, protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials. Work Environment The noise level in the work environment is usually moderate. #RayzeBio, #LI-Onsite If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Compensation Overview: Indianapolis - RayzeBio - IN: $107,904 - $130,754 The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee's work schedule, job-related knowledge, and experience. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit ************************************* Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients' lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to **************************. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: ********************************************* Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
    $107.9k-130.8k yearly Auto-Apply 32d ago
  • Field Applications Program (East Region)

    Texas Instruments 4.6company rating

    Principal research scientist job in Carmel, IN

    **Change the world. Love your job.** When you join TI, you will participate in the Career Accelerator Program (CAP), which provides professional and technical training and resources to accelerate your ramp into TI and set you up for long-term career success. Within this program, we also offer function-specific technical training and on-the-job learning opportunities that will encourage you to solve problems through a variety of hands-on, meaningful experiences from your very first day on the job. The FAST (Field Applications & Sales Training) Program is designed to prepare Sales & Applications team members for customer-oriented careers that pair technical skills with business perspectives. The program provides experiences that help rising TIers understand how to successfully grow TI's business and to thrive throughout their entire TI career. There are two available FAST program tracks: (1) Field Applications and (2) Technical Sales. **Field Applications Engineer track** This 12-month experience aims to establish rising Field Applications Engineers (FAEs) as technical TI experts with customer engineers and internal teams. The track includes 3 rotations: **Rotation 1, Field Sales Office (FSO):** The FSO rotation is centered on learning how to work directly with customers to solve technical challenges, and to ultimately maximize TI's revenue by providing customers with the systems-level solutions that best address their design needs. Among other aspects, the FSO rotation focuses on analyzing technical trade-offs, understanding component selection, and solving design and cost challenges. **Rotation 2, Mass Market (MM):** The MM rotation is designed to train FAEs on how to scale any action within a given sector or EE across multiple customers. Rotators will participate in innovative projects to help create new and more efficient sales processes. This rotation focuses on learning how to leverage TI's resources, automation, practice scalable selling techniques, decision making in imperfect circumstances, and direct customer interactions. **Rotation 3, Business Unit/Systems Engineering & Marketing (BU/SEM):** This rotation provides hands-on experiences that help future FAEs understand how various TI components fit together to provide systems-level solutions for customer designs. Rotators will be trained on business acumen, technical capabilities, and processes for new product definition and introduction. This rotation focuses on technical product selection, schematic/layout capture, PCB layouts, fabrication processes, board bring up and validation. Upon successful completion of the Field Applications Engineer track, participants are welcomed as FAEs on TI's Worldwide Sales & Applications team. FAE responsibilities include: + Using various sales tools and relationships with design engineering to identify all potential projects + Providing customers with proactive proposals for complete, system-level solutions that maximize TI content + Using broad technical expertise to influence customers' part selection process while favorably positioning TI versus competition Texas Instruments will not sponsor job applicants for visas or work authorization for this position. **Why TI?** + Engineer your future. We empower our employees to truly own their career and development. Come collaborate with some of the smartest people in the world to shape the future of electronics. + We're different by design. Diverse backgrounds and perspectives are what push innovation forward and what make TI stronger. We value each and every voice, and look forward to hearing yours. Meet the people of TI (*************************************** UI/CandidateExperience/en/sites/CX/pages/4012) + Benefits that benefit you. We offer competitive pay and benefits designed to help you and your family live your best life. Your well-being is important to us. **About Texas Instruments** Texas Instruments Incorporated (Nasdaq: TXN) is a global semiconductor company that designs, manufactures and sells analog and embedded processing chips for markets such as industrial, automotive, personal electronics, communications equipment and enterprise systems. At our core, we have a passion to create a better world by making electronics more affordable through semiconductors. This passion is alive today as each generation of innovation builds upon the last to make our technology more reliable, more affordable and lower power, making it possible for semiconductors to go into electronics everywhere. Learn more at TI.com . Texas Instruments is an equal opportunity employer and supports a diverse, inclusive work environment. All qualified applicants will receive consideration for employment without regard to race, color, religion, creed, disability, genetic information, national origin, gender, gender identity and expression, age, sexual orientation, marital status, veteran status, or any other characteristic protected by federal, state, or local laws. If you are interested in this position, please apply to this requisition. **Minimum requirements:** + Bachelors degree in Electrical Engineering, Electronics Technology, Electrical Engineering Technology, Electrical and Computer Engineering or related field + Cumulative 3.0/4.0 GPA or higher **Preferred qualifications:** + Experience with lab equipment such as oscilloscopes, along with soldering and debugging skills + Programming skills in C/C++ (LabView recommended) + Demonstrated strong analytical and problem solving skills + Excellent communication and presentation skills + Ability to work in teams and collaborate effectively with people in different functions + Strong time management skills that enable on-time project delivery + Ability to build lasting, influential relationships, both inside and outside the organization + Ability to work effectively in a fast-paced and ever-changing environment + Ability to take initiative and drive for results + Ability to influence decisions through a sense of urgency and competitive drive **ECL/GTC Required:** Yes
    $128k-164k yearly est. 60d+ ago
  • Field Application Scientist

    ATS Corporation

    Principal research scientist job in Indiana

    BioDot is looking for cytogeneticists to help support and expand the CellWriter automated system for Cytogenetics and Molecular Cytogenetics. This revolutionary product for FISH dramatically changed lab economics and CellWriter is shaping the way FISH and Karyotyping experiments are performed around the world. The ideal candidate will be able to work in a fast paced environment, have a passion for cytogenetics, and an interest in automation. This is a great opportunity for a technologist who wants to expand their career outside the standard laboratory environment and participate in the growth phase of a new technology. The Field Application Scientist (CW) plays a pivotal role in ensuring the seamless operation and optimal performance of BioDot instruments across various customer environments. This multifaceted position blends technical expertise with customer-centric responsibilities, requiring a deep understanding of mechanical and electrical systems, proficiency in software and hardware functionalities, and the ability to troubleshoot and resolve complex issues. Beyond technical prowess, the FAS engages extensively with customers, providing comprehensive training on instrument operation, delivering software and hardware support, and fostering strong professional relationships. With a commitment to continuous improvement and innovation, the FAS contributes to protocol development, implements advanced programming solutions, and collaborates across cross-functional teams to enhance workflow efficiency and drive strategic initiatives. Overall, the FAS role embodies a unique blend of technical acumen, customer interaction, and proactive problem-solving essential for delivering exceptional support and driving innovation in the field of bioinstrumentation. Essential Duties Instrumentation Inspection and Troubleshooting: Assist with mechanical and electrical inspection and troubleshooting of instrumentation. Perform troubleshooting of application protocols and instrumentation. Maintenance and Repairs: Repair, service, and perform preventative maintenance on BioDot instruments. Optimize liquid handling performance of instrumentation, including camera systems. Customer Interaction and Training: Interact with customers to train them on instrument operation and maintenance. Provide basic and advanced software and hardware training. Develop and deliver training materials for BioDot Sales and Applications teams. Conduct training of new employees. Field Service Travel: Travel for installation, preventative maintenance, and service of instruments at customer locations and BioDot headquarters. Perform installation qualification (IQ), operational qualification (OQ), and guide customers on performance qualification (PQ) at customer locations. Participate in trade shows and conferences, including setup, presentation, and lead generation. Technical Support: Respond promptly to online technical support inquiries, including direct interaction with customers via email and phone. Independently assist customers in reaching their goals and provide application-specific protocols and training. Document application support work and customer visits within the company database or other required formats. Contribute to the company knowledge base. Cross-functional Team Collaboration: Work as part of a global support team, interacting daily with design engineers, mechanical and electrical engineers, production personnel, service engineers, and sales team members. Participate in Factory and Site Acceptance Testing (FAT/SAT). Protocol Development: Develop application-specific protocols on BioDot products by interpreting procedures provided by customers or the BioDot Sales team. Develop protocols for complex automated instrumentation that requires integration with third-party devices. Demonstrate advanced programming skills and software functions to control instrumentation. Innovation and Improvement: Contribute innovative ideas to improve workflow and instrumentation. Demonstrate out-of-the-box thinking to troubleshoot issues. Professional Relationships and Conduct: Maintain professional relationships with customers and co-workers. Understand customer expectations and schedule work accordingly. Work independently and make intelligent decisions based on experience and knowledge. Assist co-workers in need and contribute to a collaborative work environment. Reporting and Documentation: Report to the manager of the assigned territory. Maintain support for existing customers by providing additional application protocols, training, etc. Respond to online technical support inquiries, including direct interaction with customers by email and phone. Additional Duties: Participate in sales calls, demos, lectures, and presentations. Upselling of services. Answer technical questions in a timely manner. Perform other work-related duties as assigned. Qualifications Education: Must have a BA/BS in Biology, Molecular Biology, Chemistry, or a similar subject. Preferred: Master's or Doctorate degree in Biology, Molecular Biology, Chemistry, or a similar subject. Cytogenetic ASCP certification Technical Skills: Strong mechanical and electrical troubleshooting skills. Proficiency in software and hardware related to BioDot instruments. Experience with IQ/OQ/PQ processes and documentation. Minimum of 2-5 years of experience with analytical instrumentation, laboratory automation, electronics, mechanical engineering, or computers is highly desirable. Proficiency with standard laboratory software/interfaces (Microsoft Excel, Word, Vendor Supplied/Custom Developed LIS). Cytogenetics Experience: Must have 1-3 years of Cytogenetics experience performing wet lab and analysis in FISH and Karyotyping. Experience in high throughput lab environments is a plus. Interpersonal Skills: Excellent customer service and communication skills. Ability to work independently and as part of a cross-functional team. Excellent verbal and written communication skills, along with strong PC skills (Office, Google Docs, database usage, help desk software), and organizational abilities are required. Additional Skills: Strong problem-solving skills and innovative thinking. Ability to travel frequently (up to 50%-75%) for field service and training, both domestically and internationally. The compensation range for this role is $80,000-$100,000.00. Join the Winning Team at BioDot, a great place to automate your future! Take your place among the best in the business, and grow your career with the Life Science BioDot division at ATS. We attract some of the most talented and motivated individuals from a range of fields, with our global offering and growth opportunities as we expand throughout the world. We want you to be a part of our TEAM!!! Work in an environment where a passion for innovation is combined with an uncompromised commitment to quality. Benefits BioDot offers: Competitive compensation package Comprehensive benefits (including health, dental vision and employee assistance program) Employee Stock Purchase Plan Eligibility 401k with employer match Tuition reimbursement Wellness reimbursement Paid time off Annual paid volunteer day off Fully climate-controlled environment Professional growth opportunities And more!
    $80k-100k yearly 60d+ ago
  • Senior Polymers Scientist

    8427-Janssen Cilag Manufacturing Legal Entity

    Principal research scientist job in Warsaw, IN

    At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at ******************* Job Function: R&D Product Development Job Sub Function: Materials/Biomaterials Science Job Category: Scientific/Technology All Job Posting Locations: Warsaw, Indiana, United States of America Job Description: We are searching for a Senior Polymers Scientist to join our DePuy Synthes located in Warsaw, IN. Fueled by innovation at the intersection of biology and technology, we're developing the next generation of smarter, less invasive, more personalized treatments. Are you passionate about improving and expanding the possibilities of Orthopedics? Ready to join a team that's reimagining how we heal? Our Orthopedics teams help keep more than 6 million people moving each year while delivering clinical and economic value to surgeons and healthcare systems. Our teams build solutions for joint reconstruction; trauma and craniomaxillofacial; sports, extremities, and elective foot and ankle; spine; and robotics and digital surgery. Your unique talents will help patients on their journey to wellness. Learn more at *******************/medtech Johnson & Johnson announced plans to separate our Orthopaedics business to establish a standalone Orthopaedics company, operating as DePuy Synthes. The process of the planned separation is anticipated to be completed within 18 to 24 months, subject to legal requirements, including consultation with works councils and other employee representative bodies, as may be required, regulatory approvals and other customary conditions and approvals. Should you accept this position, it is anticipated that, following conclusion of the transaction, you would be an employee of DePuy Synthes, and your employment would be governed by DePuy Synthes employment processes, programs, policies, and benefit plans. In that case, details of any planned changes would be provided to you by DePuy Synthes at an appropriate time and subject to any necessary consultation processes. Purpose: You will address material selection challenges, investigate material failures, and become the historian and expert for our full range of polymer materials used in our diverse products. Apply your understanding of polymer structure-property relationships to improve materials and/or process performance and participate hands-on in the lab to characterize polymers. Provide technical support materials to Orthopaedics business partners to improve device function, quality, and cost. Apply problem-solving and failure analysis skills to collaboratively solve technical challenges, lead technical investigations, develop testing methodologies, perform materials characterization studies, interpret test results, and communicate to internal and external partners of different levels and backgrounds the significance of and impact to material and property performance. You will: Conduct failure analysis investigations for Orthopaedics polymeric implants and instruments. Use good laboratory practices to perform hands-on polymer materials evaluations using mechanical testing, thermal analysis, microscopy, spectroscopy, and chromatography. Write and maintain technical reports, materials and processes specifications, work instructions, test methods, and procedures. Lead lab instrument/equipment installation qualifications and test method validations. Guide statistical process validation programs. Ensures adherence to all company safety policies and procedures and other safety precautions within the work area. Responsible for ensuring personal and Company compliance with all Federal, State, local and Company regulations, policies, and procedures. Performs other duties assigned as needed. Qualifications: Required: Bachelor's degree in Materials Science, Polymers Science, or Polymers Chemistry with 4+ years experience, MS or Ph.D. with 2+ years polymers experience. Knowledgeable of polymer chemistry, processes, and polymer characterization applicable to medical devices. Outstanding communication and technical writing skills to communicate highly technical concepts and data to diverse technical and non-technical partners. Attention to detail is vital. Ability to independently perform hands-on lab work, as well as to direct technicians and co-ops, performing chemical, physical, and mechanical testing in a polymer science lab. Strong project management and organizational skills. Ability to use computer and laboratory equipment and software, statistical data analysis, and test results interpretation. Demonstrated problem solving capabilities. Understanding of statistical validation methodologies Preferred: Prior experience with polymers used in the medical device industry is desirable. Medical device or polymer failure analysis experience is strongly preferred. Highly motivated and enthusiastic self-starter works under own initiative and as an extraordinary teammate. Other: 5-10% travel, primarily domestic. #LI-AM2 Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (********************************) or contact AskGS to be directed to your accommodation resource Required Skills: Polymer Preferred Skills: Coaching, Detail-Oriented, Raw Materials, Research and Development, Researching, SAP Product Lifecycle Management
    $91k-131k yearly est. Auto-Apply 1d ago
  • Senior Scientist, Radiochemistry

    Telix Pharmaceuticals

    Principal research scientist job in Fishers, IN

    See Yourself at Telix The Sr Scientist, Radiochemisty position will support the development of clinical-stage radiopharmaceutical assets. This role is responsible for managing the development required to ensure manufacturing and QC procedures meet the corporate requirements to support clinical trials, regulatory submissions, and transition to commercial-stage manufacturing. Key Accountabilities Interface with key stakeholders, including external CMOs, to manage the development of manufacturing and QC procedures for clinical-stage radiopharmaceutical assets in compliance with all applicable GMP regulations. Demonstrate the ability to manage multiple CMOs with little oversight from management. Manage the development and validation of manual or automated manufacturing procedures as required. Manage the development and validation of non-compendial QC procedures as required. Generate development, validation, method transfer, and various other types of protocols and reports. Author CMC sections for INDs, NDAs, BLAs, and foreign equivalents. Generate SOPs for manufacturing and QC procedures. Support method transfers to external manufacturers. Participate in the streamlining, optimization, and scale-up of manufacturing procedures in preparation for commercial supply. Provide technical support for manufacturing and QC procedures for all Telix products as required. Ensure all documentation generated is consistent with Telix QMS and general principles of GMP manufacturing. Education and Experience Bachelor's degree plus 8+ years experience, or Masters degree plus 6+ years experience, or doctorate plus 5+ years experience required. Practical radiochemistry experience is required. Experience developing HPLC, TLC, or GC QC methods for radiopharmaceuticals is required. Experience working in GMP-compliant manufacturing is required. Strong written and verbal communication skills. Experience with conjugation and radiolabeling of biologics is preferred. Experience of method development to support regulatory filings is preferred.
    $87k-128k yearly est. Auto-Apply 48d ago
  • Senior Scientist - Gene-to-Structure

    Helix Biostructures

    Principal research scientist job in Indianapolis, IN

    Helix BioStructures, LLC (HBS) is a contract research organization based in Indianapolis, Indiana, providing early drug discovery services to the biopharmaceutical industry. HBS maintains a full suite of services that encompass chemical & structural analysis, protein production, computational modeling, and design. HBS's core and most popular services are structural biology imaging techniques: X-ray Crystallography and Cryo-EM. HBS was founded in 2018 and has grown considerably. We are looking to add an experienced senior scientist to join our Indianapolis-based team. Main Responsibilities This senior-level scientist will support our protein production and structural biology pipelines by producing proteins and setting up crystallization and/or cryo-EM experiments, interfacing with our clients, and writing technical project reports. The scientist will be expected to improve upon current state-of-the-art methods to accelerate research processes. This scientist will also be responsible for managing and supporting the team, planning & tracking all projects to produce and deliver high-quality work to our clients. A proven track record in managing people and projects with a deep understanding of protein construct design, expression, and purification of challenging proteins, biophysical characterization, and structural biology techniques is essential. Highly desirable hands-on experiences include: (a) Broad experience in protein production, both expression and purification (mammalian and prokaryotic) (b) Biochemical, biophysical, and structural characterization of over-expressed and purified proteins. (c) Crystallizing proteins and nucleic acids. (d) Cryo-EM grid preparation, data collection, and processing. (e) Structure building and refinement program usage to phase difficult data sets. In addition to expertise in crystallography and/or cryo-EM, this scientist will employ a range of experimental strategies (biochemical, biophysical, and/or computational) to support our client's structure-based drug discovery, antibody discovery, and/or protein engineering. Accordingly, proficiency and a passion for exploring the structural basis of protein-protein and protein-ligand interactions are essential. The successful candidate will be a technical expert who can lead from the bench and collaborate with colleagues on multiple projects in parallel. Overall, you will be an outstanding protein scientist and structural biologist, collaborator, project and people leader who will significantly impact our portfolio with the unique opportunity to help drive discovery projects from inception to early development. Additional Responsibilities - Document experimental data and communicate research priorities, progress, and results with clients/project teams. - Provide the team with project details, priorities, technical and scientific guidance, deliverables, and timelines. - The candidate will be responsible for managing the team and all projects and providing support for project success. - This candidate will manage his/her direct reports and provide all the support they need. - The candidate will be responsible for timely updates on project statuses, reporting to their supervisor informally and to Helix's customers by formal report writing and oral presentations. Required Qualifications - Ph.D. in biochemistry, biophysics, protein engineering, and/or structural biology with experience on multiple challenging protein targets. Productive postdoctoral training and/or industry experience is expected. - Industry experience: 3-7 years post-Ph.D. (not including time as an academic postdoc). - Demonstrated competency in protein expression and purification strategies using bacterial, insect, and/or mammalian cell lines. - Demonstrated knowledge of construct design for structural/biophysical studies and biophysical characterization of proteins. - Extensive experience in protein X-ray crystallography from protein sample assessment, crystallization, optimization, and data collection to structure determination and refinement. - Experience with model building and refinement software, such as Phenix, Autoproc, CCP4, Chimera, Rosetta, ShelX, Coot, and Pymol. - Experience with crystallization robots and standard analytical techniques associated with assessing protein quality during purification. - Extensive experience reproducing and advanced optimization of crystal hits to produce diffraction-quality crystals. - Extensive experience with co-crystallization and soaking techniques to help produce ligand-bound protein structures. - Demonstrated experience and knowledge in people and project management. - Strong leadership, written and oral communication skills, and attention to detail. Additional qualifications - Hands-on experience engineering protein constructs and optimizing the production of protein targets for structural and functional studies. - Experience in biophysical characterization tools and strategies. - Ability to generate and characterize milligram quantities of high-quality protein reagents - Experience with protein engineering and/or design approaches. - Analysis, design, and/or computational approaches to investigate ligand-protein complexes. - Experience with Cryo-EM is a plus, especially grid vitrification, screening, and data processing using RELION. - Lead and provide technical and scientific guidance to the team and manage all projects to produce high-quality results and meet the timeline. - Excellent communication, interpersonal, organizational, and management skills. - Fearless attitude to tackle longstanding complex problems. Location This position is based in Indianapolis, Indiana, and does NOT offer a hybrid option. Interaction with external service vendors is also expected. Physical Requirements Able to lift 30 lb objects. Able to visualize microscopic objects under microscopes. Non-standard work schedule, travel, and lab safety Able to adhere to safe work practices and perform lab work with appropriate personal protective equipment such as but not limited to safety goggles, facial mask, gloves, lab coat/ protective gowning, and closed-toe shoes. Able to work at flexible hours occasionally when performing time-sensitive experiments. Other job details - Eligible for Relocation Assistance - Competitive Salary + Bonus - Competitive PTO - Retirement (matching 401K) - Health/Dental/Vision Insurance - Company Apple computer Helix BioStructures, LLC is an equal opportunity employer, and we embrace the increasingly diverse world around us. Helix BioStructures, LLC prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status.
    $87k-127k yearly est. 60d+ ago
  • Senior Scientist - Immunoassay and PCR

    Early Is Good Inc.

    Principal research scientist job in Indianapolis, IN

    We're looking for a passionate, results-driven scientist committed to early cancer detection. If you thrive in fast-paced environments, uphold high ethical standards, and are eager to shape the future of cancer care, we'd love to hear from you. This is a key role on our Assay Product Development team and your responsibility will be to drive the advancement of our proprietary nanotechnology multi-omics assay portfolio. You will be involved in all stages from development, optimization and validation. You must have at least 5 years of industry experience in immunoassay development and a strong desire to develop and commercialize best-in-class ultrasensitive immunoassays for oncology diseases. You should be a self-starter, adaptable, and action-driven, capable of thriving in a fast-paced environment. Key responsibilities ● Creating, coordinating, and executing experiments to support late-phase development activities for DNA/RNA and protein Immunoassays on various types of biological specimens. ● Providing technical expertise for immunoassay and PCR development activities, including assay development, optimization, calibrator and control evaluations, design verification and validation. ● Planning development activities, executing experiments and studies, and documenting results within a design change control environment in accordance with appropriate regulatory guidelines. ● Applying analytical and statistical techniques to diagnose performance issues, develop and test solutions, and implement improvements to reduce variability and enhance the quality of test results. ● Developing conclusions and effectively communicating results to both internal and external audiences. ● Documentation skills that will hold up to the scrutiny of a regulatory agency. About you Must have: ● Based on level of education; MS eight (8+) years of experience and PhD (5+) or more years of experience as a scientist in clinical molecular diagnostic assays. ● A work history that includes previous employment in the pharmaceutical, biotechnology, CRO (Contract Research Organization) or animal health industries ● Experience with assay development in blood/urine-based immunoassays. ● Have experience working in a regulated environment that may include GLP or CLIA ● Experience in developing validation plans for immunoassays and PCR assays that meet GLP criteria. ● Advanced understanding of ligand binding immunoassays and analytical instrumentation ELISA, chemiluminescence/FRET/BRET/ fluorescence/Bioluminescence assays development. ● Expertise using analytical and statistical methods: Design of Experiments (DoE), ANOVA, JMP or other statistical software. ● Experience working with human and animal tissues and biological fluids. Nice to have: ● Experience in biomarker discovery ● Experience executing validation studies ● Experience on immunoassay platforms that may include Meso Scale Discovery (MSD), ELISA, Gyros or Quanterix ● A publication history in biologic drug development, bioanalytical method validations, immunoassays or molecular assays ● A work history that demonstrates the ability to drive the development of new products or services related to immunoassay and PCR assays ● Background in nanotechnology. We offer a competitive salary & benefits package. If you have any questions about the job, please send an email to [email protected]. We look forward to hearing from you.
    $87k-127k yearly est. 60d+ ago

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