Principal research scientist jobs in Memphis, TN

We are seeking a highly motivated and innovative Principal Scientist with specialized expertise in drug discovery to direct our Chemical Induced Proximity Center in the highly collaborative Department of Chemical Biology and Therapeutics. The World's Brightest Minds Always Innovate At St. Jude Children's Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That's why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. The incumbent will be responsible for driving strategic decisions throughout the various stages of the small molecule drug discovery process focusing on chemically induced proximity platforms. Experience with use of computational tools including Artificial Intelligence (AI) and Machine Learning (ML) in virtual screening, small molecule design and optimization is preferred. Set up the chemistry strategy for projects and advance drug discovery programs by collaboratively interacting cross-functionally within departmental collaborative centers and various departments at the institution. Lead and manage a team of scientists and large-scale, multidisciplinary projects through proactive research collaboration, and provide direction in specific area of expertise. Contribute to recruiting and growing the team, guiding and mentoring junior staff. Stay at the forefront of induced proximity platforms, including but not limited to PROTACs, molecular glues, and other bifunctional or allosteric modulators. Evaluate new technologies, chemical tools, and screening platforms that can accelerate the development of proximity-based therapeutics. Design and optimize focused chemical libraries to identify hits, leads, and drug candidates that induce selective protein interactions and cellular phenotypic changes. Maintain collaborative partnerships while ensuring recognition on collaborating publications and patents. Lead and manage a number of contract research organizations (CRO) and external chemistry partners across the globe. Oversee structure-activity relationship (SAR) studies to enhance potency, selectivity, and drug-like properties of candidate molecules. Lead efforts to improve the pharmacokinetic, pharmacodynamic, and toxicological profiles of compounds in collaboration with ADMET and DMPK teams. Serve as functional expert in due diligences for assets in-licensing and discovery partnerships. Responsible for leading publication efforts in high-impact scientific journals. Experience in drug discovery in Pharma/Biotech industry highly preferred. Experience with computational design or AI/ML preferred. PhD with management experience preferred. This is a senior leadership role with a focus on advancing cutting-edge drug discovery programs for childhood catastrophic diseases using the latest approaches in proximity-based targeting. Specifically, based on the mechanistic basis of disease, our goal is to develop unique chemical approaches (protein degraders, synthetic gene regulators and/or functional effectors) to degrade or manipulate targets relevant to pediatric oncology, neurodegenerative disorders, and sickle cell disease. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. PhD preferred. Minimum Experience: Fifteen (15) years of relevant work experience is required with a Bachelor's degree. Thirteen (13) years of relevant work experience is required with a Master's degree. Ten (10) years or relevant work experience is required with a PhD. Better at Work. Better at Life. When you work at St. Jude, you'll join a highly collaborative work culture that inspires you every day to be your best. With opportunities for learning and growth, you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a world-class institution. This includes work-life balance with generous paid time-off and on-campus conveniences that make life a little easier. Join us and you'll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a “Best Place to Work.” Benefits Your health and well-being are important to us. That's why St. Jude Children's Research Hospital provides employees with high-quality benefits choices. We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents. View all the benefits offered including Medical & Prescription Drug Plans, Dental Plan, Vision Plan, Financial Security, Retirement Plan, Living Well - Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St. Jude. Have More in Memphis Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can “Have More in Memphis.” Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $138,320 - $262,080 per year for the role of Principal Scientist in Chemical Induced Proximity. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Meet the Team Splunk, a Cisco company, is building a safer, more resilient digital world with an end‑to‑end, full‑stack platform designed for hybrid, multi‑cloud environments. Join the Foundational Modeling team at Splunk, where we advance the state of AI for high‑volume, real‑time, multi‑modal machine‑generated data - including logs, time series, traces, and events. We combine deep AI research expertise with the scale and operational excellence of Splunk and Cisco's global engineering capabilities. Our work spans networking, security, observability, and customer experience - designing and deploying foundation models that enhance reliability, strengthen security, prevent downtime, and deliver predictive insights across Splunk Observability, Security, and Platform at enterprise scale. You'll be part of a culture that values technical excellence, impact‑driven innovation, and cross‑functional collaboration - all within a flexible, growth‑oriented environment. Your Impact * Lead the research, design, and deployment of large‑scale foundation models for machine‑generated data - primarily time series, augmented with logs traces, and events. * Optimize distributed training and inference pipelines to maximize accuracy, performance, and efficiency at scale. * Work closely with engineering, product, and data science to ensure solutions meet defined technical requirements and deliver tangible business impact. * Mentor team members and contribute directly to model architecture reviews, experimental design, and production rollout processes. * Stay current with AI/ML developments and integrate relevant advancements into ongoing projects and technical plans. Minimum Qualifications: * PhD in Computer Science, or related quantitative field, plus 1+ years of industry research experience. * Proven track record in at least one of the following areas: large language modeling for both structure and unstructured data, deep learning‑based time series modeling, advanced anomaly detection, and multi-modality modeling. * Solid proficiency in Python and deep learning frameworks (e.g., PyTorch, TensorFlow) * Experience translating research ideas into production systems. Preferred Qualifications: * Deep Learning for Time Series & Forecasting - Proven expertise designing and deploying architectures such as temporal transformers, temporal convolutional networks, and spatial‑temporal models. * Advanced Anomaly Detection - Experience creating robust, scalable approaches (statistical, deep learning, or hybrid) for high‑volume, real‑time time series data. * Multi‑Modal AI Modeling - Strong track record fusing logs, time series, traces, tabular data, and graphs for foundation models tackling complex operational insights. * Probabilistic Forecasting & Uncertainty Quantification - Skills in Bayesian deep learning and probabilistic models to capture and communicate predictive uncertainty. * Large‑Scale Training & Optimization - Experience optimizing model architectures, distributed training pipelines, and inference efficiency to minimize cost and latency while preserving accuracy. * MLOps & Continuous Learning - Fluency in automated retraining, drift detection, incremental updates, and production monitoring of ML models. * Strong Research Track Record - Publications in top AI/ML conferences or journals (e.g., NeurIPS, ICML, ICLR, AAAI, CVPR, ACL, KDD) demonstrating contributions to state‑of‑the‑art methods and real‑world applications. Why Cisco? At Cisco, we're revolutionizing how data and infrastructure connect and protect organizations in the AI era - and beyond. We've been innovating fearlessly for 40 years to create solutions that power how humans and technology work together across the physical and digital worlds. These solutions provide customers with unparalleled security, visibility, and insights across the entire digital footprint. Fueled by the depth and breadth of our technology, we experiment and create meaningful solutions. Add to that our worldwide network of doers and experts, and you'll see that the opportunities to grow and build are limitless. We work as a team, collaborating with empathy to make really big things happen on a global scale. Because our solutions are everywhere, our impact is everywhere. We are Cisco, and our power starts with you. Message to applicants applying to work in the U.S. and/or Canada: The starting salary range posted for this position is $174,500.00 to $226,500.00 and reflects the projected salary range for new hires in this position in U.S. and/or Canada locations, not including incentive compensation*, equity, or benefits. Individual pay is determined by the candidate's hiring location, market conditions, job-related skillset, experience, qualifications, education, certifications, and/or training. The full salary range for certain locations is listed below. For locations not listed below, the recruiter can share more details about compensation for the role in your location during the hiring process. U.S. employees are offered benefits, subject to Cisco's plan eligibility rules, which include medical, dental and vision insurance, a 401(k) plan with a Cisco matching contribution, paid parental leave, short and long-term disability coverage, and basic life insurance. Please see the Cisco careers site to discover more benefits and perks. Employees may be eligible to receive grants of Cisco restricted stock units, which vest following continued employment with Cisco for defined periods of time. U.S. employees are eligible for paid time away as described below, subject to Cisco's policies: * 10 paid holidays per full calendar year, plus 1 floating holiday for non-exempt employees * 1 paid day off for employee's birthday, paid year-end holiday shutdown, and 4 paid days off for personal wellness determined by Cisco * Non-exempt employees receive 16 days of paid vacation time per full calendar year, accrued at rate of 4.92 hours per pay period for full-time employees * Exempt employees participate in Cisco's flexible vacation time off program, which has no defined limit on how much vacation time eligible employees may use (subject to availability and some business limitations) * 80 hours of sick time off provided on hire date and each January 1st thereafter, and up to 80 hours of unused sick time carried forward from one calendar year to the next * Additional paid time away may be requested to deal with critical or emergency issues for family members * Optional 10 paid days per full calendar year to volunteer For non-sales roles, employees are also eligible to earn annual bonuses subject to Cisco's policies. Employees on sales plans earn performance-based incentive pay on top of their base salary, which is split between quota and non-quota components, subject to the applicable Cisco plan. For quota-based incentive pay, Cisco typically pays as follows: * .75% of incentive target for each 1% of revenue attainment up to 50% of quota; * 1.5% of incentive target for each 1% of attainment between 50% and 75%; * 1% of incentive target for each 1% of attainment between 75% and 100%; and * Once performance exceeds 100% attainment, incentive rates are at or above 1% for each 1% of attainment with no cap on incentive compensation. For non-quota-based sales performance elements such as strategic sales objectives, Cisco may pay 0% up to 125% of target. Cisco sales plans do not have a minimum threshold of performance for sales incentive compensation to be paid. The applicable full salary ranges for this position, by specific state, are listed below: New York City Metro Area: $199,700.00 - $292,800.00 Non-Metro New York state & Washington state: $174,500.00 - $260,500.00 * For quota-based sales roles on Cisco's sales plan, the ranges provided in this posting include base pay and sales target incentive compensation combined. Employees in Illinois, whether exempt or non-exempt, will participate in a unique time off program to meet local requirements.

Clinical Research Investigator DM Clinical Research, the largest privately-owned research management organization in the Houston area and one of the top 50 in the country, is looking for an Investigator for our sites in Memphis, TN. This individual will conduct all clinical trials (studies) according to ICH, GCP, local regulations, study protocols, and company processes. Responsibilities Ensures the medical well-being and safety of the participants through the safe performance and execution of the studies. Assists in maintaining clinical oversight and quality on the studies registered on and delivers on study targets, thereby contributing to the commercial success of the site. Reviews enrollment progress, pre-screening and screening success rates, screen failure rates, safety, and retention of participants. Interprets protocols and IB and participates in initiatives to strategize for patient recruitment. Carries out clinical evaluation and assessment of participants to ensure eligible participants are enrolled onto studies. Ensures and protects the welfare and safety of participants through ethical conduct. Fulfills and comply with all medical duties as per protocol, SOP/COP and ICH GCP and local regulations. Exercises meticulous attention to detail in documentation and patient care. Requirements Medical License (MD, DO) At least 2 years of experience as a Clinical Research Investigator. Spanish Bilingual a plus.

A Few Words About Us Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing. Job Description They must have protein purification experience including non-labeled proteins and They are NOT looking for candidates with molecular/PCR/gene cloning, etc. Summary Description: Position will be responsible for overseeing and executing the process design and manufacturing of monoclonal antibodies, polyclonal antibodies and recombinant proteins products and services sold into IVD industry. The Senior Manufacturing Process Scientist will possess ‘hands-on' experience with various forms of chromatography (affinity, ion exchange, HIC, etc.), centrifugation, TFF/DF/UF, cell culture and fermentation. Experience with aseptic techniques particularly useful in the areas of eukaryotic cell culture, bacterial and yeast fermentation. The individual must be capable of executing and authoring Master Batch Records and Standard Operating Procedures in compliance with current Good Manufacturing Practices. This position will supervise Production Technicians. Duties: o Perform bio separation of recombinant proteins, monoclonal/polyclonal antibodies. Bioseparation methods to include, but not limited to, preparative centrifugation, TFF filtration, and chromatographic methods (ion exchange, size exclusion, affinity, etc.). o Familiar with In vitro cell culture of monoclonal antibodies and fermentation of recombinant proteins. o Develop and perform various analytical protein methods for process monitoring and characterization of in-process and final product. The methods to include but not limited to SDS-PAGE, Western Blot, ELISA, UV-VIS, and Immunoassays methods. o Assess feasibility of contract manufacturing cell culture and purification opportunities, participate in development of proposal and costing estimates. o Author master batch records and SOPs for transferred/developed process in compliance with all current GMP regulations and company SOPs. o Train Production Technicians in upstream and downstream manufacturing processes. o Develop strategies to improving yields and reducing overall manufacturing costs. Investigate alternative materials or new process equipment to improve efficiency. o Write and execute validation protocols for new and existing manufacturing processes. o Assist with the writing of technical reports, customer proposals, and product release specifications Qualifications Required Qualifications: o Ph.D. with 3+ years of industrial experience or MS with 6+ years of industrial experience in a GMP or GLP environment. o Extensive knowledge and hands on experience of protein purification and characterization. o Experience with virus like proteins and viruses a plus. A knowledge of AKTA Unicorn software and disposable systems a plus. o Hands on experience with in vitro cell culture and recombinant protein fermentation o Ability to independently apply bioseparation basic theory and scientific principles to conduct downstream process development for proteins. o Proven experience with process scale-up procedures. o Extensive knowledge and hands on experience with protein analytical methods including (SDS-PAGE, Western Blot, ELISA, BCA, UV-VIS, HPLC methods etc). o Concise and accurate oral and written reporting of technical including batch records, SOPs, validation protocols and customer proposals. Requirements (Physical, Mental, Environmental Demands): o Ability to walk up and down several flights of stairs throughout the work day in a multi-location facility. o Must be able to concentrate, analyze and solve complex issues throughout the course of the work day. o Ability to work on a PC including repetitive use of a keyboard and mouse for long periods throughout the course of the work day. o Ability to sit for long periods of time, stoop, reach, bend throughout the course of the work day. o Must be able to lift up to 30lbs. multiple times daily. o Must be able to travel by air/car to other locations of MBI as needed. o May be required to work outside normal business hours including evenings and/or weekends to support business needs. Additional Information Manisha Jathar 732 429 1850

The University of Tennessee Health Science Center Department of Pediatrics Research seeks a highly motivated and innovative Postdoctoral Scholar. This position offers a unique opportunity to contribute to cutting-edge research at the intersection of artificial intelligence, machine learning, and healthcare. The successful candidate will develop and apply advanced machine learning techniques (e.g. explainable, ethical, empathic and agentic AI), natural language processing (NLP), large language models (LLMs), data science methods, and mHealth to analyze large-scale, multidimensional, and multimodal datasets. The goal is to generate predictive models that provide valuable causal and probabilistic insights into clinical and population health outcomes. In addition to technical research responsibilities, the incumbent will play a key role in implementing and managing a multi-phase study designed to improve HPV vaccination uptake among adolescents. Responsibilities Develops and applies advanced ML algorithms, NLP models, and LLMs to analyze complex data. Designs and implements novel data science methodologies for predictive modeling, causal inference, and probabilistic analysis in clinical and population health contexts. Conducts data mining and knowledge discovery from multidimensional and multimodal datasets. Collaborates with a diverse team of researchers, clinicians, and public health experts to translate data insights into actionable outcomes. Contributes to scientific publications, presentations, and grant applications. Performs other duties as assigned. Qualifications Ph.D. in a relevant discipline (e.g. Medical Informatics, Computer Science, Data Science, Computational Social Science, Epidemiology, Biostatistics, etc.) Strong research track record, programming, and implementation skills, along with excellent communication, organizational, and project management skills. Experience in both qualitative and quantitative research and studying and implementing public health interventions are highly desirable.

**Meet the Team** Splunk, a Cisco company, is building a safer, more resilient digital world with an end‑to‑end, full‑stack platform designed for hybrid, multi‑cloud environments. Join the Foundational Modeling team at Splunk, where we advance the state of AI for high‑volume, real‑time, multi‑modal machine‑generated data - including logs, time series, traces, and events. We combine deep AI research expertise with the scale and operational excellence of Splunk and Cisco's global engineering capabilities. Our work spans networking, security, observability, and customer experience - designing and deploying foundation models that enhance reliability, strengthen security, prevent downtime, and deliver predictive insights across Splunk Observability, Security, and Platform at enterprise scale. You'll be part of a culture that values technical excellence, impact‑driven innovation, and cross‑functional collaboration - all within a flexible, growth‑oriented environment. **Your Impact** + Lead the research, design, and deployment of large‑scale foundation models for machine‑generated data - primarily time series, augmented with logs traces, and events. + Optimize distributed training and inference pipelines to maximize accuracy, performance, and efficiency at scale. + Work closely with engineering, product, and data science to ensure solutions meet defined technical requirements and deliver tangible business impact. + Mentor team members and contribute directly to model architecture reviews, experimental design, and production rollout processes. + Stay current with AI/ML developments and integrate relevant advancements into ongoing projects and technical plans. **Minimum Qualifications:** + PhD in Computer Science, or related quantitative field, plus 1+ years of industry research experience. + Proven track record in at least one of the following areas: large language modeling for both structure and unstructured data, deep learning‑based time series modeling, advanced anomaly detection, and multi-modality modeling. + Solid proficiency in Python and deep learning frameworks (e.g., PyTorch, TensorFlow) + Experience translating research ideas into production systems. **Preferred Qualifications:** + Deep Learning for Time Series & Forecasting - Proven expertise designing and deploying architectures such as temporal transformers, temporal convolutional networks, and spatial‑temporal models. + Advanced Anomaly Detection - Experience creating robust, scalable approaches (statistical, deep learning, or hybrid) for high‑volume, real‑time time series data. + Multi‑Modal AI Modeling - Strong track record fusing logs, time series, traces, tabular data, and graphs for foundation models tackling complex operational insights. + Probabilistic Forecasting & Uncertainty Quantification - Skills in Bayesian deep learning and probabilistic models to capture and communicate predictive uncertainty. + Large‑Scale Training & Optimization - Experience optimizing model architectures, distributed training pipelines, and inference efficiency to minimize cost and latency while preserving accuracy. + MLOps & Continuous Learning - Fluency in automated retraining, drift detection, incremental updates, and production monitoring of ML models. + Strong Research Track Record - Publications in top AI/ML conferences or journals (e.g., NeurIPS, ICML, ICLR, AAAI, CVPR, ACL, KDD) demonstrating contributions to state‑of‑the‑art methods and real‑world applications. **Why Cisco?** At Cisco, we're revolutionizing how data and infrastructure connect and protect organizations in the AI era - and beyond. We've been innovating fearlessly for 40 years to create solutions that power how humans and technology work together across the physical and digital worlds. These solutions provide customers with unparalleled security, visibility, and insights across the entire digital footprint. Fueled by the depth and breadth of our technology, we experiment and create meaningful solutions. Add to that our worldwide network of doers and experts, and you'll see that the opportunities to grow and build are limitless. We work as a team, collaborating with empathy to make really big things happen on a global scale. Because our solutions are everywhere, our impact is everywhere. We are Cisco, and our power starts with you. **Message to applicants applying to work in the U.S. and/or Canada:** The starting salary range posted for this position is $174,500.00 to $226,500.00 and reflects the projected salary range for new hires in this position in U.S. and/or Canada locations, not including incentive compensation*, equity, or benefits. Individual pay is determined by the candidate's hiring location, market conditions, job-related skillset, experience, qualifications, education, certifications, and/or training. The full salary range for certain locations is listed below. For locations not listed below, the recruiter can share more details about compensation for the role in your location during the hiring process. U.S. employees are offered benefits, subject to Cisco's plan eligibility rules, which include medical, dental and vision insurance, a 401(k) plan with a Cisco matching contribution, paid parental leave, short and long-term disability coverage, and basic life insurance. Please see the Cisco careers site to discover more benefits and perks. Employees may be eligible to receive grants of Cisco restricted stock units, which vest following continued employment with Cisco for defined periods of time. U.S. employees are eligible for paid time away as described below, subject to Cisco's policies: + 10 paid holidays per full calendar year, plus 1 floating holiday for non-exempt employees + 1 paid day off for employee's birthday, paid year-end holiday shutdown, and 4 paid days off for personal wellness determined by Cisco + Non-exempt employees** receive 16 days of paid vacation time per full calendar year, accrued at rate of 4.92 hours per pay period for full-time employees + Exempt employees participate in Cisco's flexible vacation time off program, which has no defined limit on how much vacation time eligible employees may use (subject to availability and some business limitations) + 80 hours of sick time off provided on hire date and each January 1st thereafter, and up to 80 hours of unused sick time carried forward from one calendar year to the next + Additional paid time away may be requested to deal with critical or emergency issues for family members + Optional 10 paid days per full calendar year to volunteer For non-sales roles, employees are also eligible to earn annual bonuses subject to Cisco's policies. Employees on sales plans earn performance-based incentive pay on top of their base salary, which is split between quota and non-quota components, subject to the applicable Cisco plan. For quota-based incentive pay, Cisco typically pays as follows: + .75% of incentive target for each 1% of revenue attainment up to 50% of quota; + 1.5% of incentive target for each 1% of attainment between 50% and 75%; + 1% of incentive target for each 1% of attainment between 75% and 100%; and + Once performance exceeds 100% attainment, incentive rates are at or above 1% for each 1% of attainment with no cap on incentive compensation. For non-quota-based sales performance elements such as strategic sales objectives, Cisco may pay 0% up to 125% of target. Cisco sales plans do not have a minimum threshold of performance for sales incentive compensation to be paid. The applicable full salary ranges for this position, by specific state, are listed below: New York City Metro Area: $199,700.00 - $292,800.00 Non-Metro New York state & Washington state: $174,500.00 - $260,500.00 * For quota-based sales roles on Cisco's sales plan, the ranges provided in this posting include base pay and sales target incentive compensation combined. ** Employees in Illinois, whether exempt or non-exempt, will participate in a unique time off program to meet local requirements. Cisco is an Affirmative Action and Equal Opportunity Employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, sexual orientation, national origin, genetic information, age, disability, veteran status, or any other legally protected basis. Cisco will consider for employment, on a case by case basis, qualified applicants with arrest and conviction records.

The Lead-Bioinformatics Research Scientist takes a lead role in data analysis, data visualization, statistical analysis, experimental design, database development, mathematical modeling, and novel method development. Working independently, provides bioinformatics analysis for investigators and communicates analytical process and results. A Lead Bioinformatic Research Scientist position is available in the lab of Dr. Jian Xu at Department of Pathology and Center of Excellence for Leukemia Studies (CELS) at St. Jude Children's Research Hospital to study the genomic and/or metabolic mechanisms controlling stem cell development and blood cancers. Our lab uses cutting-edge genomics, metabolomics and bioinformatics approaches in a multi-disciplinary and collaborative team setting. Our recent studies include the development of the CRISPR CAPTURE approach ( Cell 170:1028), the analysis of rewired BCAA metabolism ( Cancer Discovery 9:1228), the role of pathogenic non-coding variants ( Cancer Discovery 10:724), retrotransposon silencing ( Nature Genetics 53:672), therapy resistance in hematologic malignancies ( Cancer Discovery 13:170), and metabolic rewiring in erythropoiesis ( Science 386:eadh9215). The main responsibilities will be developing and implementing bioinformatic methodologies for integrative genomic and metabolomic studies of childhood cancers; overseeing operations related to genomic and metabolomic data processing and analysis within the Advanced Technology & Genomics (ATG) core, including software pipelines for short-read and long-read-based genome sequencing, single-cell genomics, high throughput metabolomic profiling, and stable isotope tracing; managing databases; and providing bioinformatic support and services to other lab members and St. Jude researchers. Candidates must hold a MS or PhD degree with a strong background and expertise in genomics, computational biology, metabolism research, and/or cancer biology. The ideal candidate will exhibit independence, flexibility and creativity with a record of scientific productivity. Previous experience in single-cell genomics, computational biology, and/or hematology-oncology is strongly preferred. Interested individuals should upload a CV, a short summary of research interest and experience, and a list of three references. Job Responsibilities: Lead data analysis and deliver high-quality results by formulating advanced and/or new analytical approaches with the available data/ to address challenging data analysis questions. Deliver data files, and document the analytical process. Participate in manuscript preparation at project's conclusion. Establish and document protocols or best practices for common research tasks. Recommend ideas to automate or improve existing analysis methods and implement the improvement. Evaluate and test new methods and technologies. Develop reusable code and pipeline. Participate in redistribution and education of novel methods to research community when required. Lead and participate in the department's developmental projects and interdepartmental team projects. Act as a project manager when required. Perform other duties as assigned to meet the goals and objectives of the department and institution. Maintains regular and predictable attendance. Minimum Education and/or Training: Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field. Master's degree or PhD preferred. Minimum Experience: Minimum Requirement: Bachelor's degree with 10+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry). Experience Exception: Master's degree with 8+ years of relevant post-degree experience (OR) PhD with 5+ years of relevant post-degree experience. Substantial experience in at least one programming or scripting language and at least one statistical package, with R preferred. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $125,840 - $238,160 per year for the role of Lead-Bioinformatics Research Scientist. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

A Few Words About Us Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing. Job Description Job Position: Senior Manufacturing Technician or Senior Manufacturing Process Scientist Location: Memphis, TN Duration: Fulltime Permanent Relocation: Relocation Package is Provided Our Client is looking for Senior Manufacturing Process Scientist- With protein purification etc. experience…..!!!!! Position will be responsible for overseeing and executing the process design and manufacturing of monoclonal antibodies, polyclonal antibodies and recombinant proteins products and services sold into IVD industry. The Senior Manufacturing Process Scientist will possess ‘hands-on' experience with various forms of chromatography (affinity, ion exchange, HIC, etc.), centrifugation, TFF/DF/UF, cell culture and fermentation. Experience with aseptic techniques particularly useful in the areas of eukaryotic cell culture, bacterial and yeast fermentation. The individual must be capable of executing and authoring Master Batch Records and Standard Operating Procedures in compliance with current Good Manufacturing Practices. This position will supervise Production Technicians. SUMMARY & RESPONSIBILITIES: • Perform bio separation of recombinant proteins, monoclonal/polyclonal antibodies. Bioseparation methods to include, but not limited to, preparative centrifugation, TFF filtration, and chromatographic methods (ion exchange, size exclusion, affinity, etc.). • Familiar with In vitro cell culture of monoclonal antibodies and fermentation of recombinant proteins. • Develop and perform various analytical protein methods for process monitoring and characterization of in-process and final product. The methods to include but not limited to SDS-PAGE, Western Blot, ELISA, UV-VIS, and Immunoassays methods. • Assess feasibility of contract manufacturing cell culture and purification opportunities, participate in development of proposal and costing estimates. • Author master batch records and SOPs for transferred/developed process in compliance with all current GMP regulations and company SOPs. • Train Production Technicians in upstream and downstream manufacturing processes. • Develop strategies to improving yields and reducing overall manufacturing costs. Investigate alternative materials or new process equipment to improve efficiency. • Write and execute validation protocols for new and existing manufacturing processes. • Assist with the writing of technical reports, customer proposals, and product release specifications Qualifications QUALIFICATIONS AND SKILLS NEEDED: • Ph.D. with 3+ years of industrial experience or MS with 6+ years of industrial experience in a GMP or GLP environment. • Extensive knowledge and hands on experience of protein purification and characterization. • Experience with virus like proteins and viruses a plus. A knowledge of AKTA Unicorn software and disposable systems a plus. • Hands on experience with in vitro cell culture and recombinant protein fermentation • Ability to independently apply bioseparation basic theory and scientific principles to conduct downstream process development for proteins. • Proven experience with process scale-up procedures. • Extensive knowledge and hands on experience with protein analytical methods including (SDS-PAGE, Western Blot, ELISA, BCA, UV-VIS, HPLC methods etc). • Concise and accurate oral and written reporting of technical including batch records, SOPs, validation protocols and customer proposals. • MUST BE US CITIZEN or GREEN CARD holder only. Requirements (Physical, Mental, Environmental Demands): • Ability to walk up and down several flights of stairs throughout the work day in a multi-location facility. • Must be able to concentrate, analyze and solve complex issues throughout the course of the work day. • Ability to work on a PC including repetitive use of a keyboard and mouse for long periods throughout the course of the work day. • Ability to sit for long periods of time, stoop, reach, bend throughout the course of the work day. • Must be able to lift up to 30lbs. multiple times daily. • Must be able to travel by air/car to other locations of MBI as needed. • May be required to work outside normal business hours including evenings and/or weekends to support business needs. Additional Information Regards Pooja Mishra Clinical Recruiter Integrated Resources, Inc. IT Life Sciences Allied Healthcare CRO Certified MBE |GSA - Schedule 66 I GSA - Schedule 621I Tel: 732 429 1636 (W) 732-549-2030 x 214 | (F) 732-549-5549 Gold Seal JCAHO Certified ™ for Health Care Staffing “INC 5000's FASTEST GROWING, PRIVATELY HELD COMPANIES” (8th Year in a Row)

St. Jude is seeking a seasoned bioinformatics research scientist to lead and participate in the development of multiple scientific products and initiatives on the St. Jude Cloud project. This position will work on a wide array of scientific problems applicable to large-scale pediatric cancer data sharing. Concretely, this role will serve as the domain expert working on at least one of our product development teams building applications within the St. Jude Cloud ecosystem, including the large-scale data sharing application, Genomics Platform (******************************* the pediatric cancer reference knowledgebase, PeCan (**************************** and the genomic and epigenomic visualization platform, Visualization Community (************************** Cross-ecosystem projects, such as developing a comprehensive diagnosis ontology used across St. Jude Cloud applications and collecting/harmonizing the catalog of scientific information shared through St. Jude Cloud will be a major focus. Finally, this position will have a specific emphasis on developing and publishing bioinformatics workflows that are (a) used to harmonize data published on St. Jude Cloud and (b) are available for external users of St. Jude Cloud. Job Responsibilities: Lead data analysis and deliver high-quality results by formulating advanced and/or new analytical approaches with the available data/ to address challenging data analysis questions. Deliver data files, and document the analytical process. Participate in manuscript preparation at project's conclusion. Establish and document protocols or best practices for common research tasks. Recommend ideas to automate or improve existing analysis methods and implement the improvement. Evaluate and test new methods and technologies. Develop reusable code and pipeline. Participate in redistribution and education of novel methods to research community when required. Lead and participate in the department's developmental projects and interdepartmental team projects. Act as a project manager when required. Perform other duties as assigned to meet the goals and objectives of the department and institution. Maintains regular and predictable attendance. Minimum Education and/or Training: Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field. Master's degree or PhD preferred. Minimum Experience: Minimum Requirement: Bachelor's degree with 10+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry). Experience Exception: Master's degree with 8+ years of relevant post-degree experience (OR) PhD with 5+ years of relevant post-degree experience. Substantial experience in at least one programming or scripting language and at least one statistical package, with R preferred. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $125,840 - $238,160 per year for the role of Lead-Bioinformatics Research Scientist. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

A Few Words About Us Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing. Our client is a public and rapidly growing diagnostics company that is looking to expand their Quality team in Memphis TN. They are willing to assist with relocation. Relocation assistance is provided! Excellent benefits, competitive salary, and stock options. Job Description Under direct supervision, responsible for design, performance and interpretation of experiments in support of the company's product development. Responsibilities: Responsible for the design and conduct of experiments as defined by work streams in accordance with the company's Quality System and to regulatory standards Ensures that work is completed to agreed timelines, communicating delays or issues to supervisor in timely manner Prioritizes workload to insure key objectives are met on time May supervise the work of a junior member of staff Presents data at internal and external meetings Ensures that conclusions in written reports reflect the data presented and reports are of the highest quality When required, operate as a scientist in support of running Laboratories, ensuring that the Quality Management System, including ISO 9001:2008, ISO 13485:2003, CLIA and CAP, is adhered to at all times and in all aspects of the job Perform other duties in departments on an occasional basis to meet critical company objectives Follows all company safety policies & other safety precautions within work area Regular attendance and timeliness is essential Qualifications BS or MS Degree in life sciences, Higher preferred Experience with cell culture techniques imperative Hands-on experience with flow cytometry and PCR techniques Demonstrated understanding of the diagnostic and pharmaceutical industries Familiarity with Quality System concepts and requirements including GMP and ISO Working knowledge of ELISA and ELISPOT a distinct advantage Expert at analyzing data Must be proficient in MS Office Additional InformationAll your information will be kept confidential according to EEO guidelines.

We are looking for an experienced cell biologist to participate in our exciting studies of the human protein kinome. This Lead/Senior Scientist position is part of the Blue Sky Initiative “Seeing the Invisible in Protein Kinases” at St. Jude Children's Research Hospital in Memphis, TN. As a member of the Cell-Based Assays team, the candidate will use their molecular biology, biochemistry, and cell culture skills to perform research that translates novel insights regarding kinase structure and regulation in vitro into functional effects in cells. Additionally, the candidate will assist in performing cell-based analysis in high-, medium-, and low-throughput platforms of candidate inhibitors of kinases. The work is diverse providing an opportunity to study multiple kinases, perform appropriate background research, optimize cell-based assays of various types using many different cell lines or primary cells. Not only are the cell-based studies used to validate the structural findings, but they are also used to discover new kinase-mediated biology or new mechanisms of kinase regulation. The Blue Sky Initiative “Seeing the Invisible in Protein Kinases” is an inter-disciplinary project in the Department of Structural Biology and is supported by US $50 million in institutional funding. This large-scale project leverages ultra-high field nuclear magnetic resonance (NMR), complemented with cryo EM, X-ray crystallography, data-science and computational approaches, to characterize the conformational landscape of the human kinome. Knowledge of the conformations of kinases is then used to discover new biology regarding kinase function and regulation in cells, understand the structural and functional consequences of disease-associated mutations, and identify novel therapeutic opportunities. Responsibilities: Research kinase-mediated signaling pathways, kinase targets or kinase-dependent phosphorylation events, and cellular outcomes of such pathways for assigned kinase projects. Identify appropriate cellular assays and cells to perform structure-guided analysis of kinase signaling output and cellular phenotypes related to structure-guided perturbations in kinase regulation or function. Develop strategies and plans for implementing cell-based assays, including but not limited to evaluation of protein phosphorylation, protein interaction, protein localization, RNA abundance (qRT-PCR), protein ubiquitination, and protein abundance. Develop strategies and plans for implementing cell-based phenotypic assays, including but not limited to viability, apoptosis, autophagy, migration, or differentiation. Perform optimization and troubleshooting of cell-based assays. Perform statistical analysis using graphing software or R scripts. Interpret, analyze, and communicate cell-based assay results within the Cell-Based Assays team and with collaborators on specific kinase projects. Experience and Expertise: Experience in analysis of protein kinases and phosphorylation-dependent signaling events or pathways. Expertise in culturing a variety of types of cells, such as cancer cell lines, primary cells, mouse embryo fibroblasts, inducible human pluripotent cells, immune cells, neuronal cells, and muscle cells. Expertise in multiple methods for exogenous protein expression. Proficiency in presentation of experimental design and results using PowerPoint or similar software. Experience with mouse models, preferred but not essential. Technical Capabilities: Cloning, PCR, and qRT-PCR Sterile technique Cell transfection, transduction, or infection to exogenously express proteins of interest transiently or for cell line generation Quantitative immunoassays, such as ELISA, AlphaLISA, and Mesoscale Discovery Immunoprecipitation and Western blotting Protein-protein interaction analysis, such as proximity ligation, FRET, or NanoBit assays Flow cytometry and fluorescence-activated cell sorting (FACS) Reporter gene assays Phenotypic assays, such as viability, apoptosis, proliferation, migration, colony-forming, autophagy, endocytosis, secretion, or differentiation assays Microscopy, such as immunofluorescence, live-cell imaging, subcellular localization, colocalization analysis Cellular fractionation Competencies: Creative and results-driven with strong critical thinking and the ability to learn quickly Hardworking, well-organized, flexible, and capable of multitasking efficiently in a fast-paced environment Collaborative and efficient member of teams with diverse backgrounds and opinions Ability to prioritize work and complete assignments promptly Minimum Education and Experience for either level: Bachelor's degree in relevant scientific area is required. Minimum Experience for Senior Scientist: Ten (10) years relevant work experience is required with a Bachelor's degree. Eight (8) years of relevant work experience is required with a Master's degree. Five (5) years of relevant work experience is required with a PhD. Minimum Experience for Lead Scientist: Twelve (12) years of relevant work experience is required with a Bachelor's degree. Ten (10) years of relevant experience is required with a Master's degree. Seven (7) years of relevant work experience is required with a PhD. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Scientist, $125,840 - $238,160 per year for the role of Lead Scientist. The World's Brightest Minds Always Innovate At St. Jude Children's Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That's why we provide World-class facilities State-of-the-art technologies Extraordinary support A collaborative, bench-to-bedside environment You will see, firsthand, how your science translates into survival for the children that we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. Better at Work. Better at Life. When you work at St. Jude, you'll join a highly collaborative work culture that inspires you every day to be your best. With opportunities for learning and growth, you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a world-class institution. This includes work-life balance with generous paid time-off and on-campus conveniences that make life a little easier. Join us and you'll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a “Best Place to Work.” Have More in Memphis Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people, Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can “Have More in Memphis.” Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $125,840 - $238,160 per year for the role of Cell Assay Lead/Senior Scientist - Blue Sky Kinases. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

The Lead Scientist or Senior Scientist plays a key role in shaping and executing research strategies in collaboration with the Principal Investigator. This position designs and leads studies to address important basic science or clinical research questions within their area of expertise, often focusing on one or more specialized projects within the laboratory. The role also involves developing innovative experimental procedures and sharing significant research findings through publication. Lead Scientist Requirements: Minimum Education: Bachelor's degree in relevant scientific area is required Minimum Experience: Twelve (12) years of relevant work experience is required Ten (10) years of relevant experience is required with a Master's degree Seven (7) years of relevant work experience is required with a PhD Senior Scientist Requirements: Minimum Education: Bachelor's degree in relevant scientific area is required Minimum Experience: Ten (10) years relevant work experience is required Eight (8) years of relevant work experience is required with a Master's degree Five (5) years of relevant work experience is required with a PhD Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $125,840 - $238,160 per year for the role of Lead-Scientist OR Senior Scientist. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

We are looking for an experienced NMR spectroscopist to participate in our study of the human kinome. This Senior Scientist position is part of the Blue Sky Initiative “Seeing the Invisible in Protein Kinases” at St. Jude Children's Research Hospital in Memphis, TN. The World's Brightest Minds Always Innovate At St. Jude Children's Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That's why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. As a member of the NMR spectroscopy team, the candidate will study large and dynamic protein kinases and oligomers by solution NMR spectroscopy. The candidate will work to elucidate functional and mechanistic determinants of protein kinase activity by both NMR and a vast array of biophysical and biochemical methodologies. The candidate will work in a fast-paced multidisciplinary environment closely interacting with the biochemists, cell biologists, and computational chemists to interpret the results, formulate hypothesis, design and coordinate sample preparation and workflow. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and 1.1 GHz. The research activity will be supported by Blue Sky Initiative. The Blue Sky Initiative “Seeing the Invisible in Protein Kinases” is an inter-disciplinary project in the Department of Structural Biology and is supported by US $50 million in institutional funding. This large-scale project leverages ultra-high field nuclear magnetic resonance (NMR), complemented with cryo EM, X-ray crystallography, data-science and computational approaches, to characterize the conformational landscape of the human kinome. Knowledge of the conformations of kinases is then used to understand the structural and functional consequences of disease-associated mutations and identify novel therapeutic opportunities. Key Responsibilities: Conduct NMR experiments/projects independently under the overall direction of supervisor. Manage construct design, NMR data collection, chemical shift assignment, solution structure determination, and dynamics studies independently. Structure calculations and refinement using solution state NMR data Analysis of CEST relaxation profiles. Critically evaluate viability of kinase for dynamics and/or structural studies. Work closely with team specialists to interpret data and formulate hypothesis that advance the research goals. Train, assist and oversee the work of junior colleagues in all aspects of NMR- related projects. Independently troubleshoot, solve difficult problems, and propose solutions related to research project design and execution. Work efficiently and effectively in a collaborative and multidisciplinary team environment in full accordance with St. Jude institutional values. Ideal Candidate: Extensive experience in applying NMR techniques in characterization of the structure and dynamics of large proteins, including backbone and methyl assignment methodologies. Experience in using both automated and manual methods for NMR chemical shift assignment. Experience in performing characterization of protein dynamics using CEST. Proficient in NMR data processing. Experienced in NMR structure calculation and refinement. Highly motivated and detail oriented with excellent communications skills. Excellent organizational skills, with an ability to embrace change and multi-task in an extremely fast-paced environment. Additional preferred skills: Understand and interpret a variety multidisciplinary biochemical/biophysical data. Proficiency in using a variety of NMR processing and analysis software including nmr Pipe, nmr-fam Sparky/Poky, Bruker TopSpin, and CYANA. Proficient in Alphafold, Molecular Dynamics, and structure refinement techniques such as Amber, CNS etc. Experiences in assignment of highly deuterated methyl labeled proteins using MAGIC and other algorithms. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. PhD in Chemistry, Biochemistry, or related fields strongly preferred. Minimum Experience: Ten (10) years relevant work experience is required with a Bachelor's degree. Eight (8) years of relevant work experience is required with a Master's degree. Five (5) years of relevant work experience is required with a PhD. Benefits Your health and well-being are important to us. That's why St. Jude Children's Research Hospital provides employees with high-quality benefits choices. We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents. View all the benefits offered including Medical & Prescription Drug Plans, Dental Plan, Vision Plan, Financial Security, Retirement Plan, Living Well - Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St. Jude. The World's Best Stop at Nothing There's a reason St. Jude Children's Research Hospital is consistently ranked on Glassdoor's “Best Places to Work” list. Actually, there are more than 5,500 reasons. At our world-class pediatric research hospital, every one of our 5,500 professionals shares our commitment to making a difference in the lives of the children we serve. There's a unique bond when you are part of a team that will stop at nothing to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where all employees, regardless of their role, receive the resources, support, and encouragement to advance and grow their careers. Have More in Memphis Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can “Have More in Memphis.” Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of NMR Senior Scientist in Blue Sky Protein Kinases. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

We are seeking a highly skilled and motivated Senior Scientist to direct daily laboratory operations and spearhead method development for high-throughput screening that will uncover the therapeutic potential of intrinsically disordered regions. This is an exciting opportunity for an experienced molecular biologist to take a leadership role in a collaborative academic environment, supporting a large-scale screening project and pioneering new cell perturbation methodologies. The postholder will oversee the day-to-day operation of the experimental arm of the research group and lead the development of innovative experimental pipelines to advance lentiviral-based screening technologies across diverse biological systems. The World's Brightest Minds Always Innovate At St. Jude Children's Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That's why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. Key Responsibilities: Drive the development of innovative experimental strategies to expand and enhance the existing screening capabilities of the group. Manage laboratory operations by coordinating daily activities, maintaining and troubleshooting equipment, and ensuring adherence to institutional regulatory requirements. Support the design, optimization, and implementation of pooled lentiviral screening workflows, including peptide inhibitor and base/prime editing platforms. Develop and maintain standard operating procedures (SOPs), ensure quality control, and promote best laboratory practices. Supervise and mentor postdoctoral researchers, research assistants, and students involved in screening projects. Engage in collaborative research and contribute to publications, grant proposals, and presentations. Ideal Candidate: PhD (or equivalent experience) in Molecular Biology, Cell Biology, Genetics, or a closely related field. Extensive experience in CRISPR-based genome engineering in mammalian cell systems. Demonstrated expertise in the design, production, and application of lentiviral libraries for large-scale screening. Proven track record in developing, implementing, or applying high-throughput genetic perturbation or functional screening approaches. Demonstrated ability to manage laboratory operations, including supervision and training of staff or students. Excellent organizational, communication, and record-keeping skills. Strong problem-solving ability and capacity to work independently as well as collaboratively. Desirable Attributes: Experience with base or prime editing systems. Familiarity with large-scale data generation and interpretation in screening contexts. Evidence of contributions to collaborative research initiatives or consortia. About the Research Environment: The Davey lab has recently joined the Department of Cell and Molecular Biology to launch a research program applying high-throughput screening approaches to uncover the therapeutic potential of intrinsically disordered regions. The postholder will work within a collaborative, supportive team and benefit from world-class core facilities and excellent opportunities for professional development. What problem are we tackling? Target discovery is a critical foundation of drug development, underpinning efforts to overcome the persistent challenges of drug resistance, emerging pathogens, and complex diseases that lack effective therapies. By uncovering novel proteins and molecular pathways driving disease progression, we can enable the rational design of more selective interventions that reduce off-target effects and improve patient outcomes. The development of tool molecules, coupled with detailed characterization of their inhibitory mechanisms, provides a direct bridge between phenotypic observations and small-molecule drug design, accelerating the translation of basic discoveries into clinically actionable therapies. What is our approach? Short Linear Motifs (SLiMs) are compact functional modules embedded within the intrinsically disordered regions of proteins. They mediate a wide range of regulatory processes, including the assembly of dynamic complexes, recruitment of modifying enzymes, control of protein stability, and specification of subcellular localization. Despite their central role in cellular regulation, SLiM-binding pockets remain a largely untapped class of therapeutic targets. By applying large scale base-editing and peptide inhibitor studies the project will address three key questions: (i) How essential are SLiM-mediated interactions for cellular fitness? (ii) Does SLiM essentiality differ between healthy and diseased cells? (iii) Can these interactions be selectively targeted for therapeutic intervention? Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required Minimum Experience: Ten (10) years relevant work experience is required with a Bachelor's degree. Eight (8) years of relevant work experience is required with a Master's degree. Five (5) years of relevant work experience is required with a PhD. Better at Work. Better at Life. When you work at St. Jude, you'll join a highly collaborative work culture that inspires you every day to be your best. With opportunities for learning and growth, you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a world-class institution. This includes work-life balance with generous paid time-off and on-campus conveniences that make life a little easier. Join us and you'll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a “Best Place to Work.” Benefits Your health and well-being are important to us. That's why St. Jude Children's Research Hospital provides employees with high-quality benefits choices. We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents. View all the benefits offered including Medical & Prescription Drug Plans, Dental Plan, Vision Plan, Financial Security, Retirement Plan, Living Well - Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St. Jude. Have More in Memphis Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can “Have More in Memphis.” Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Scientist (Pooled Lentiviral Screening & Method Development). Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

We are seeking a highly motivated and service-oriented Scientist with expertise in cryo-Electron Tomography (cryo-ET) to join our team. This role supports St. Jude's expanding cryo-ET capabilities and provides direct assistance to a diverse community of researchers using state-of-the-art cryo-EM technologies to advance discoveries in pediatric cancer, infectious disease, and fundamental biology. As part of the cryo EM/ET center, the successful candidate will play a central role in enabling end-to-end cryo-ET workflows ranging from specimen preparation and cryo-FIB milling to cryo-TEM data acquisition and preliminary analysis. The position is service-oriented, collaborative, and offers opportunities to participate in technology development projects, evaluate new methods, and contribute to the strategic growth of cryo-ET capabilities within St. Jude. The World's Brightest Minds Always Innovate At St. Jude Children's Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That's why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. Key Responsibilities Provide hands-on support for cryo-ET sample preparation, including plunge freezing, high-pressure freezing, cryo-CLEM workflows, cryo-FIB lamella preparation, and TEM screening Operate, maintain, and monitor high-end cryo-EM instrumentation (Titan Krios, Glacios, Arctica and Aquilos 2) to ensure optimal performance and maximize user access Train new and experienced users in cryo-ET techniques, microscope operation, and best-practice standards aligned with cryo EM/ET center's guidelines Work closely with researchers to design and execute tomography data-collection strategies that meet research goals Perform initial quality assessment of tilt-series data and assist users with reconstruction and early-stage data processing Participate in development and optimization of emerging cryo-ET workflows, protocols, and automation strategies Maintain accurate documentation related to user training, sample preparation sessions, instrument usage, and standard operating procedures Contribute to a safe, inclusive, and service-focused environment that reflects St. Jude's commitment to excellence and collaboration Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. Minimum Experience for a Scientist Level: Eight (8) years of relevant work experience is required with a Bachelor's degree. Six (6) years of relevant work experience is required with a Master's degree. Three (3) years of relevant work experience is required with a PhD. Minimum Experience for a Senior Scientist Level: Ten (10) years relevant work experience is required with a Bachelor's degree. Eight (8) years of relevant work experience is required with a Master's degree. Five (5) years of relevant work experience is required with a PhD. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Scientist or $104,000 - $186,160 per year for the role of Senior Scientist. Preferred Qualifications & Experience: PhD or equivalent degree in Structural Biology, Biophysics, Biochemistry or a related field Demonstrated experience with cryo-EM workflows, ideally including cryo-ET sample preparation, lamella milling, and tomography data acquisition Strong understanding of microscope alignment, image acquisition parameters, and cryo-EM instrumentation Hands-on experience with tilt-series acquisition, tomogram reconstruction, and subtomogram averaging pipelines (e.g., IMOD, Dynamo, RELION, M/Warp, EMAN2) Ability to troubleshoot complex workflows and assist users with technical challenges Excellent communication skills for working in a diverse, multi-disciplinary user environment Interest in technology development, workflow automation, or method optimization. The World's Best Stop at Nothing There's a reason St. Jude Children's Research Hospital is consistently ranked on Glassdoor's “Best Places to Work” list. Actually, there are more than 5,500 reasons. At our world-class pediatric research hospital, every one of our 5,500 professionals shares our commitment to making a difference in the lives of the children we serve. There's a unique bond when you are part of a team that will stop at nothing to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where all employees, regardless of their role, receive the resources, support, and encouragement to advance and grow their careers. Better at Work. Better at Life. When you work at St. Jude, you'll join a highly collaborative work culture that inspires you every day to be your best. With opportunities for learning and growth, you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a world-class institution. This includes work-life balance with generous paid time-off and on-campus conveniences that make life a little easier. Join us and you'll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a “Best Place to Work.” Benefits Your health and well-being are important to us. That's why St. Jude Children's Research Hospital provides employees with high-quality benefits choices. We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents. View all the benefits offered including Medical & Prescription Drug Plans, Dental Plan, Vision Plan, Financial Security, Retirement Plan, Living Well - Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St. Jude. Have More in Memphis Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can “Have More in Memphis.” Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Scientist or Senior Scientist Opportunity in the St Jude cryo EM/ET center. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Are you a driven scientist with a passion for advancing our understanding of childhood immune development? The Crawford Lab is seeking a Senior Scientist to lead and shape research into the mechanisms of pediatric immunity, leveraging cutting-edge technologies and multidisciplinary approaches. The Crawford Lab About the Opportunity This is a unique opportunity to join the ground level of a new endeavor in the Crawford Lab focused on the comprehensive characterization of the human immune system throughout childhood development. You will work closely with experts in next-generation, multi-omic assays and integrative computational analysis to unravel the complexities of immunity in health, disease, and treatment. This work will need expert knowledge of human immunology, which you will apply collaboratively to: Design panels of relevant immunological markers for immune phenotyping, biological perturbations, and health or disease states. Generate gold standard data to validate novel sequencing-based approaches. Test and validate novel, sequencing-based approaches to data generation Synthesize and interpret molecular underpinnings from population-level, multi-modal data from primary samples. The ideal candidate will have extensive bench experience, a keen attention to detail, and a history of first-author publications in immunology. Success in this position also requires: Excellent communication and organizational skills The ability to multi-task and collaborate effectively Comfort working in tandem with a culturally and scientifically diverse team to achieve shared research goals We're Especially Interested in Candidates With: Deep and current knowledge of immunology literature. Extensive expertise in human peripheral or mucosal immunology. Proven research experience in innate/adaptive immunity and host-pathogen interactions. Hands-on experience studying childhood immune system development. Technical proficiency in cell culture, multiparameter flow cytometry, biomarker discovery, and primary human sample analysis. Key Responsibilities Design, execute, and oversee experiments/projects independently under the direction of the PI. Develop and refine research protocols, techniques, and procedures Analyze, organize, and interpret complex datasets-including flow cytometry and omics data. Ensure data quality and integrity; prepare reports and summaries of experimental results. Present research findings internally and at external conferences; contribute to manuscripts as co-author or lead writer. Support and optimize lab operations: recommend equipment, troubleshoot instruments, and guide process improvements. Mentor and train junior scientists and lab staff in advanced immunology methods and analytical techniques. Contribute to ongoing and new research initiatives to achieve departmental and institutional goals. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. Minimum Experience: Ten (10) years relevant work experience is required. Eight (8) years of relevant work experience is required with a Master's degree. Five (5) years of relevant work experience is required with a PhD. Why The Crawford Lab? Join a collaborative, innovative team at the forefront of childhood immunology research. Work with state-of-the-art instrumentation and contribute to discoveries that have real-world impact on pediatric health. Ready to help shape the future of childhood immunology? Submit your CV and a cover letter detailing your expertise in childhood immune systems, flow cytometry, and omics technologies. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Scientist - Human Systems Immunology (Crawford Lab). Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

St. Jude is seeking a Senior Bioinformatics Research Scientist for data science projects within the Center for Pharmacogenomics in the Department of Pharmacy and Pharmaceutical Sciences. In particular, this individual will focus on electronic health record (EHR)-driven phenotyping to support pharmacogenomics discovery research. The successful candidate will be responsible for developing and implementing new informatics tools and resources to enhance phenotyping performance or enable deep phenotyping through terminology/ontology, natural language processing, and machine learning. The role involves working with large external biobank datasets such as All of US, eMERGE, TopMed, UK BioBank, as well internal EHR data. This Bioinformatics Research Scientist will collaborate extensively with disease and/or drug experts (clinicians, clinician scientists, data scientists, and laboratory investigators) to co-develop phenotyping algorithms but is expected to serve as the domain expert in high-throughput phenotyping. Demonstrated expertise in EHR-based phenotype extraction and curation are strongly preferred. Responsibilities o Provide research support and deliver high-quality results by formulating an efficient analytical approach with the available data. o Deliver data files, and document the analytical process. May participate in manuscript preparation at project's conclusion. o Assist with establishing and documenting protocols or best practices for common research tasks, and in the formulation of analytical plans that use the best approach to address challenging data analysis questions. o Assist in the evaluation and testing of new methods and technologies. o Contribute ideas to automate or improve existing analysis methods. Implement the improvement or work with others to do so. o Participate in the department's developmental projects and interdepartmental team projects. Qualifications o Minimum Requirement: Bachelor's degree with 7+ years of relevant post-degree work experience in relevant area (e.g., bioinformatics, cheminformatics, statistics/computer science with a background in biological sciences or chemistry) (OR) Master's degree with 5+ years of relevant experience (OR) PhD with 2+ years of relevant experience. o Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred. As one of the premier pediatric research institutions in the world, St. Jude Children's Research Hospital provides exceptional resources and a supportive environment for career development. In this position, the candidate will interact with leaders in pharmacogenomics and data science in general within and outside the institution and at national/international meetings. Innovation and independence are encouraged with the goal of providing flexibility and freedom in exploring new directions. Job Responsibilities: Provide research support and deliver high-quality results by formulating an efficient analytical approach with the available data. Deliver data files, and document the analytical process. May participate in manuscript preparation at project's conclusion. Assist with establishing and documenting protocols or best practices for common research tasks, and in the formulation of analytical plans that use the best approach to address challenging data analysis questions. Assist in the evaluation and testing of new methods and technologies. Contribute ideas to automate or improve existing analysis methods. Implement the improvement or work with others to do so. Participate in the department's developmental projects and interdepartmental team projects. Perform other duties as assigned to meet the goals and objectives of the department and institution. Maintains regular and predictable attendance. Provide research support and deliver high-quality results by formulating an efficient analytical approach with the available data. Deliver data files, and document the analytical process. May participate in manuscript preparation at project's conclusion. Assist with establishing and documenting protocols or best practices for common research tasks, and in the formulation of analytical plans that use the best approach to address challenging data analysis questions. Assist in the evaluation and testing of new methods and technologies. Contribute ideas to automate or improve existing analysis methods. Implement the improvement or work with others to do so. Participate in the department's developmental projects and interdepartmental team projects. Minimum Education and/or Training: Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field. Master's degree or PhD preferred. Minimum Experience: Minimum Requirement: Bachelor's degree with 7+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry). Experience Exception: Master's degree with 5+ years of relevant post-degree experience (OR) PhD with 2+ years of relevant post-degree experience. Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Bioinformatics Research Scientist. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

The Northcott Lab in the Center of Excellence in Neuro-Oncology Sciences (CENOS) at St. Jude Children's Research Hospital is seeking a highly motivated Senior Bioinformatics Research Scientist. CENOS is a collaborative research environment that aims to drive discoveries needed to improve outcomes for children with brain tumors. Through application of cutting-edge molecular profiling to unprecedented patient cohorts and innovative model systems, CENOS members are rapidly translating laboratory findings into new treatments. Genome-wide studies of diverse pediatric brain tumor entities have identified novel mutations, defined molecular subgroups, and opened new avenues of basic, translational, and clinical investigation. The Senior Bioinformatics Research Scientist performs data analysis, data visualization, statistical analysis, experimental design, database development, mathematical modeling, and novel method development. Provides bioinformatics analysis for investigators and communicates analytical process and results. The successful candidate will contribute to discovery-driven computational studies of unprecedented multi-omic datasets obtained from children with malignant brain cancer, including single-cell, spatial, and liquid biopsy profiles. The candidate will work closely with other bioinformatics personnel within CENOS to play an integral role in exciting collaborations, both within St. Jude and with prominent external collaborators. A deep understanding of cancer genomics, human genetics, transcriptomics, or epigenetics, strong problem-solving skills, attention to detail, and critical thinking are essential for this position. The successful recruit must have the capacity to execute proficient computational analyses and troubleshooting independently, communicate effectively with the PI and collaborators, and thrive in a highly collaborative team environment. The ideal candidate should have: A PhD in bioinformatics, computational biology, data science or related field. Experience analyzing the following platforms: Single-cell/nucleus RNA-seq, spatial transcriptomics, RNA-seq, ATAC-seq, ChIP-seq/CUT&RUN, and DNA methylation A strong CV that includes publications involving cancer genomics, epigenomics, single-cell, spatial ‘omics, machine learning, and artificial intelligence. Experience in analyzing, interpreting, and visualizing human genomics datasets generated by high-throughput sequencing platforms including short- (Illumina) and long-read- (e.g. PacBio and Oxford Nanopore) whole-genome sequencing. Proficiency in relevant programming languages such as R and Python, preferably in a High-Performance Computing (HPC) environment. Proficiency in tools for ensuring reproducibility of pipelines, such as workflow management systems (e.g., nextflow or snakemake), and version control (e.g., git). Extensive expertise in data integration and harmonization. Proven problem-solving skills and collaborative nature in fast-paced environment. Excellent communication and presentation skills. Job Responsibilities: Provide research support and deliver high-quality results by formulating an efficient analytical approach with the available data. Deliver data files, and document the analytical process. May participate in manuscript preparation at project's conclusion. Assist with establishing and documenting protocols or best practices for common research tasks, and in the formulation of analytical plans that use the best approach to address challenging data analysis questions. Assist in the evaluation and testing of new methods and technologies. Contribute ideas to automate or improve existing analysis methods. Implement the improvement or work with others to do so. Participate in the department's developmental projects and interdepartmental team projects. Perform other duties as assigned to meet the goals and objectives of the department and institution. Maintains regular and predictable attendance. Minimum Education and/or Training: Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field. Master's degree or PhD preferred. Minimum Experience: Minimum Requirement: Bachelor's degree with 7+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry). Experience Exception: Master's degree with 5+ years of relevant post-degree experience (OR) PhD with 2+ years of relevant post-degree experience. Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Bioinformatics Research Scientist - Northcott Lab in the Center of Excellence in Neuro-Oncology Sciences (CENOS). Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

The Senior Bioinformatics Research Scientist performs data analysis, data visualization, statistical analysis, experimental design, database development, mathematical modeling, and novel method development. Provides bioinformatics analysis for investigators and communicates analytical process and results. Job Responsibilities: Provide research support and deliver high-quality results by formulating an efficient analytical approach with the available data. Deliver data files, and document the analytical process. May participate in manuscript preparation at project's conclusion. Assist with establishing and documenting protocols or best practices for common research tasks, and in the formulation of analytical plans that use the best approach to address challenging data analysis questions. Assist in the evaluation and testing of new methods and technologies. Contribute ideas to automate or improve existing analysis methods. Implement the improvement or work with others to do so. Participate in the department's developmental projects and interdepartmental team projects. Perform other duties as assigned to meet the goals and objectives of the department and institution. Maintains regular and predictable attendance. Minimum Education and/or Training: Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field. Master's degree or PhD preferred. Minimum Experience: Minimum Requirement: Bachelor's degree with 7+ years of relevant post-degree work in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry). Experience Exception: Master's degree with 5+ years of relevant post-degree experience (OR) PhD with 2+ years of relevant post-degree experience. Significant experience in at least one programming or scripting language and at least one statistical package, with R preferred. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Senior Bioinformatics Research Scientist. Explore our exceptional benefits! St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.