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Research Associate jobs at PTC Therapeutics - 186 jobs

  • Scientist I, DMPK

    PTC Therapeutics 4.9company rating

    Research associate job at PTC Therapeutics

    PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life's moments for children and adults living with a rare disease. At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging. Visit our website to learn more about our company and culture! Site: ************** Summary: The Scientist I, DMPK is responsible for planning and performing in vitro ADME assays that contribute to PTC's research and drug discovery activities. The incumbent is also responsible for communicating experimental results to his/her supervisor and the project team. The incumbent works cross-functionally with internal departments, and external resources as appropriate, as part of PTC's discovery science project teams. The Scientist I, DMPK supports adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate. .Job Description: ESSENTIAL FUNCTIONS Primary duties/responsibilities: With limited guidance, plans, initiates and executes DMPK studies and interprets and communicates results as part of a multi-disciplinary team. Performs hands-on in vitro drug metabolism assays, including solubility, plasma protein binding, tissue binding, B/P ratio, LogD/LogP/pKa measurement, and metabolic stability, etc. Develops and implements bioanalytical methods (LC-MS/MS). Collaborates with discovery teams to design and conduct in vitro drug metabolism assays. Interprets and presents data/results to internally and externally in cross-functional teams. Documents experiment details in laboratory notebook and writes reports. Ensures the scientific quality of the experimental data. May provide oversight, and/or lead interactions with, the external Contract Research Organizations (CROs). Abides by all safety and regulatory guidelines. Contributes to general lab needs such as: Equipment maintenance Troubleshoot Performs other tasks and assignments as needed and specified by management. KNOWLEDGE/SKILLS/ABILITIES REQUIRED Hands-on experience in in vitro ADME screening assays. Knowledge of drug metabolism in discovery preclinical research. Knowledge in the principles of LC-MS/MS based small molecule bioanalysis. Experience in developing protocols and writing study reports. Ability to work on complex problems to produce experimental data across one or more projects. Ability to work independently and collaboratively in a fast-paced, matrixed, team environment consisting of internal and external team members. Ability to work effectively in a multi-disciplinary team environment. Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines. Proficiency with Microsoft Office. Excellent verbal and written communication skills. Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects. * Minimum level of education and years of relevant work experience. PhD in biology, pharmaceutical science, pharmacology, or other related scientific discipline OR a Master's degree in these same disciplines and a minimum of 3 years of experience in drug metabolism in a pharmaceutical, biotechnology or related environment. *Special knowledge or skills and/or licenses or certificates preferred. Hands on experience in operating and general troubleshooting of contemporary LC-MS instruments and automated liquid handlers. Hands on experience with cell cultures. * Travel requirements 0-10% Laboratory based position. Expected Base Salary Range $111,400 - $133,000. The base salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position they are being considered for, as well as review of internal equity. In addition to base salary, PTC employees are also eligible for short- and long-term incentives. All eligible employees may also enroll in PTC's medical, dental, vision, and retirement savings plans. EEO Statement: PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination. Click here to return to the careers page
    $111.4k-133k yearly Auto-Apply 8d ago
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  • Research Associate II, Analytical Sciences (Contract)

    ORIC Pharmaceuticals 4.5company rating

    South San Francisco, CA jobs

    ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients' lives by Overcoming Resistance In Cancer. ORIC's clinical stage product candidates include (1) rinzimetostat (ORIC-944), an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) enozertinib, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers. Beyond these two product candidates, ORIC is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms. ORIC has offices in South San Francisco and San Diego, California. For more information, please go to ******************* and follow us on X or LinkedIn. We are seeking a highly motivated Research Associate II (Contractor) with a proven record of sustained laboratory achievement and innovation to join our growing PharmSci group at ORIC Pharmaceuticals. The selected candidate will provide lab support across various projects and teams; contribute to our shared mission of bringing new therapies to cancer patients. Job Description Perform sample analysis using general laboratory techniques, such as weighing, pipetting, and operating laboratory instruments (HPLC, LC-MS, GC, UV-Vis, KF, dissolution apparatus, etc.). Execute analysis with a solid understanding of the test procedures, underlying science and proper instrument operation, ensuring accurate and reliable results. Utilize available software to control instruments, collect data, process and calculate results, and prepare comprehensive reports. Maintain precise and comprehensive records of all analyses in a lab notebook, ensuring compliance with company standards and promoting traceability and consistency in data reporting. Prepare test solutions, reagents, and samples for analysis, ensuring accuracy and strict adherence to written instructions and procedures. Prepare presentation materials and clearly communicate research results to manager, and at internal/external meetings. Work cross-functionally with Process Chemistry and Formulation Development colleagues. Qualifications Requires a B.Sc. degree in chemistry with a minimum of 3 years of relevant research experience, or a M.Sc. degree with at least 1 year of hands-on pharmaceutical/biotech industry experience, or equivalent, in the field of new drug discovery and development. Hands-on experience with laboratory techniques, including chromatography (e.g., HPLC, GC, LC/MS), spectroscopy (e.g., UV-Vis, FTIR), titration methods (e.g., Karl Fischer, acid-base), dissolution testing, particle size analysis (by laser diffraction), microscopy, and other compendial methods. Experience using laboratory software to collect, analyze, and report data. This might include instrument control software (Chemstation, Empower, etc.) or data analysis programs (Excel, etc.). Demonstrated ability to take initiative, ownership, problem identification, problem solving and input into experimental design aspects. A proven record of sustained laboratory achievement and innovation. Familiarity with industry guidelines such as ICH guidelines, USP requirements, FDA guidance, and good laboratory practices (GLP). Exceptional safety and organizational skills and attention to detail when handling samples, recording data, and preparing reports. Demonstrated ability to work independently and efficiently in a collaborative, fast-paced, integrated, multidisciplinary team environment. Additional Information The anticipated salary range for candidates who will work on-site at our South San Francisco location is between $45.00-$50.00 per hour. The final wage offered to a successful candidate will be dependent on several factors that may include, title, type and length of experience within the role, type and length of experience within the industry, education, geography, and other job-related factors. ORIC Pharmaceuticals, Inc. is an equal opportunity employer. ORIC does not discriminate based on race, color, religion, gender, sexual orientation, gender identity, age, national origin, disability status, protected veteran status, or any other legally protected characteristics.
    $45-50 hourly 3d ago
  • Research Associate II, Analytical Sciences (Contract)

    Oric Pharmaceuticals, Inc. 4.5company rating

    South San Francisco, CA jobs

    ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients' lives by Overcoming Resistance In Cancer. ORIC's clinical stage product candidates include (1) rinzimetostat (ORIC-944), an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) enozertinib, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers. Beyond these two product candidates, ORIC is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms. ORIC has offices in South San Francisco and San Diego, California. For more information, please go to ******************* and follow us on X or LinkedIn. We are seeking a highly motivated Research Associate II (Contractor) with a proven record of sustained laboratory achievement and innovation to join our growing PharmSci group at ORIC Pharmaceuticals. The selected candidate will provide lab support across various projects and teams; contribute to our shared mission of bringing new therapies to cancer patients. Job Description * Perform sample analysis using general laboratory techniques, such as weighing, pipetting, and operating laboratory instruments (HPLC, LC-MS, GC, UV-Vis, KF, dissolution apparatus, etc.). * Execute analysis with a solid understanding of the test procedures, underlying science and proper instrument operation, ensuring accurate and reliable results. * Utilize available software to control instruments, collect data, process and calculate results, and prepare comprehensive reports. * Maintain precise and comprehensive records of all analyses in a lab notebook, ensuring compliance with company standards and promoting traceability and consistency in data reporting. * Prepare test solutions, reagents, and samples for analysis, ensuring accuracy and strict adherence to written instructions and procedures. * Prepare presentation materials and clearly communicate research results to manager, and at internal/external meetings. * Work cross-functionally with Process Chemistry and Formulation Development colleagues. Qualifications * Requires a B.Sc. degree in chemistry with a minimum of 3 years of relevant research experience, or a M.Sc. degree with at least 1 year of hands-on pharmaceutical/biotech industry experience, or equivalent, in the field of new drug discovery and development. * Hands-on experience with laboratory techniques, including chromatography (e.g., HPLC, GC, LC/MS), spectroscopy (e.g., UV-Vis, FTIR), titration methods (e.g., Karl Fischer, acid-base), dissolution testing, particle size analysis (by laser diffraction), microscopy, and other compendial methods. * Experience using laboratory software to collect, analyze, and report data. This might include instrument control software (Chemstation, Empower, etc.) or data analysis programs (Excel, etc.). * Demonstrated ability to take initiative, ownership, problem identification, problem solving and input into experimental design aspects. * A proven record of sustained laboratory achievement and innovation. * Familiarity with industry guidelines such as ICH guidelines, USP requirements, FDA guidance, and good laboratory practices (GLP). * Exceptional safety and organizational skills and attention to detail when handling samples, recording data, and preparing reports. * Demonstrated ability to work independently and efficiently in a collaborative, fast-paced, integrated, multidisciplinary team environment. Additional Information The anticipated salary range for candidates who will work on-site at our South San Francisco location is between $45.00-$50.00 per hour. The final wage offered to a successful candidate will be dependent on several factors that may include, title, type and length of experience within the role, type and length of experience within the industry, education, geography, and other job-related factors. ORIC Pharmaceuticals, Inc. is an equal opportunity employer. ORIC does not discriminate based on race, color, religion, gender, sexual orientation, gender identity, age, national origin, disability status, protected veteran status, or any other legally protected characteristics.
    $45-50 hourly 5d ago
  • ADC Biologist, BioConjugation, Antibody Drug Conjugate

    Astellas Pharma 4.9company rating

    South San Francisco, CA jobs

    Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas! Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at **************** . **Purpose:** Our research division is looking for a Scientist to lead bioconjugation for Antibody-Drug Conjugates (ADCs), primarily focusing on bioconjugation and ADC characteristics to drive projects in SSF. In this position, you will guide the establishment of efficient conjugation, spanning from the development of novel ADC technologies to the creation of clinical candidates. You'll work closely with relevant departments both domestically and internationally to advance our pipeline. **Essential Job Responsibilities:** + Actively participate in cross functional ADC projects to guide ADC discovery and development + Design and execute in vitro and in vivo assays and studies to evaluate ADC mechanism of action, potency, internalization, and payload release + Support the development and implementation of new methodologies to improve ADC screening and characterization. + Analyze, interpret, and present complex datasets to project teams and senior leadership. + Serve as an ADC Subject Matter Expert (SME), offering appropriate advice and solutions. + Develop novel ADC-related technologies and explore external technological advancements + Contribute to patents, publications, and technical reports **Qualifications Required:** + PhD with typically 5+ years' experience in ADC discovery and development + Deep understanding of ADC biology and MOA + Desire and ability to work in cross-functional, flexible and team-oriented environment + CRO management experience + Well-balanced communication skills (active & passive) in own language and in English **Preferred:** + Experience in antibody-related modalities development especially in antibody-drug conjugates (ADCs) + Experience working with cross functional teams + Experience in different payload classes and understanding of their MOA + Experience in oncology research. + Experience in patent application + Experience in collaborations with external research groups **Working Environment:** + This position is based in SSF and will require on-site work. **Salary Range:** $119,000-$187,000 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience, and organizational equity considerations). **Benefits:** + Medical, Dental and Vision Insurance + Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down + 401(k) match and annual company contribution + Company paid life insurance + Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions + Long Term Incentive Plan for eligible positions + Company-paid fleet vehicle for eligible positions + Referral bonus program \#LI-TR1 Category Biologics Engineering Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans
    $119k-187k yearly 34d ago
  • Research Associate

    Frontage Laboratories 3.9company rating

    Hayward, CA jobs

    Research Associate Title: Research Associate Department: ADME Department Reports to: Group Leader - ADME Department Classification: Full-time About Us: Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials. Position/Job Summary: This position will support experiment design, data collection, analysis, troubleshooting, and data reporting within the ADME department. This includes gathering data on pre-clinical compound parameters using a variety of techniques, organizing and processing the data using statistical and analytical methods to reach meaningful conclusions, and reporting observations to clients and other decision-makers. Roles & Responsibilities: Report to the senior team leader. Work and collaborate daily with a group of in vitro assay biologists within the ADME department. Learn from and teach other group members to improve skills, increase productivity, and take part in cross-training of all ADME assays. Maintain a detailed laboratory notebook. Develop compound methods and collect data using LC-MS/MS and other modalities (HPLC, spectrophotometry, etc.) Conduct day-to-day testing of compounds in several cell/protein-based in vitro assays or experiments in a team-oriented environment. Analyze and interpret data using different software programs (Sciex Analyst, DiscoveryQuant, GraphPad prism, MS Excel, etc.) Prepare reports and communicate with collaborators and clients. Multitask, recognize problems, provide input to solutions, draft reports, and communicate results proficiently with clients and in lab meetings. Contribute to basic lab maintenance such as preparing buffers, cleaning, ordering, stocking, and follow-up. Communicate and work closely with other departments to finish collaboration projects in a timely manner. Offer drug discovery screening and IND filing support for multiple client-based projects Other duties as assigned Education, Experience & Skills Required: BS or MS in biology, chemistry, or related area. 2-4 years of related experience in the biotech, pharma or preclinical CRO industry. Working experience with LC-MS/MS, HPLC, bioanalytical studies preferred. Strong problem solving and troubleshooting skills with demonstrated ability to resolve complex situations that require a logical, analytical and methodical approach. Self-motivated to multitask, initiate projects, and work both independently and in a team environment to meet deadlines Excellent organization and planning skills with attention to detail. Committed to customer satisfaction and focused on the importance of quality. Excellent interpersonal and communication skills. Hands-on exposure to general biotech laboratory equipment. A preferred candidate will have a good understanding and knowledge of laboratory tools, techniques, methods, and underlying principles. Work experience in cell-culture or in an in vitro ADME/DMPK lab preferred but not required. A theoretical understanding of different ADME assays (solubility, microsomal stability, plasma and blood stability, plasma protein binding, permeability, CYP enzyme and transporter inhibition and substrate determination, etc.) preferred but not required. Significant Safety or Working Considerations: May work with potentially infectious samples of human and/or animal origin (i.e. blood, tissues, etc.). May handle hazardous chemicals. Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.
    $64k-102k yearly est. Auto-Apply 60d+ ago
  • Research Associate

    Frontage Laboratories 3.9company rating

    Hayward, CA jobs

    Job Description Research Associate Title: Research Associate Department: ADME Department Reports to: Group Leader - ADME Department Classification: Full-time About Us: Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials. Position/Job Summary: This position will support experiment design, data collection, analysis, troubleshooting, and data reporting within the ADME department. This includes gathering data on pre-clinical compound parameters using a variety of techniques, organizing and processing the data using statistical and analytical methods to reach meaningful conclusions, and reporting observations to clients and other decision-makers. Roles & Responsibilities: Report to the senior team leader. Work and collaborate daily with a group of in vitro assay biologists within the ADME department. Learn from and teach other group members to improve skills, increase productivity, and take part in cross-training of all ADME assays. Maintain a detailed laboratory notebook. Develop compound methods and collect data using LC-MS/MS and other modalities (HPLC, spectrophotometry, etc.) Conduct day-to-day testing of compounds in several cell/protein-based in vitro assays or experiments in a team-oriented environment. Analyze and interpret data using different software programs (Sciex Analyst, DiscoveryQuant, GraphPad prism, MS Excel, etc.) Prepare reports and communicate with collaborators and clients. Multitask, recognize problems, provide input to solutions, draft reports, and communicate results proficiently with clients and in lab meetings. Contribute to basic lab maintenance such as preparing buffers, cleaning, ordering, stocking, and follow-up. Communicate and work closely with other departments to finish collaboration projects in a timely manner. Offer drug discovery screening and IND filing support for multiple client-based projects Other duties as assigned Education, Experience & Skills Required: BS or MS in biology, chemistry, or related area. 2-4 years of related experience in the biotech, pharma or preclinical CRO industry. Working experience with LC-MS/MS, HPLC, bioanalytical studies preferred. Strong problem solving and troubleshooting skills with demonstrated ability to resolve complex situations that require a logical, analytical and methodical approach. Self-motivated to multitask, initiate projects, and work both independently and in a team environment to meet deadlines Excellent organization and planning skills with attention to detail. Committed to customer satisfaction and focused on the importance of quality. Excellent interpersonal and communication skills. Hands-on exposure to general biotech laboratory equipment. A preferred candidate will have a good understanding and knowledge of laboratory tools, techniques, methods, and underlying principles. Work experience in cell-culture or in an in vitro ADME/DMPK lab preferred but not required. A theoretical understanding of different ADME assays (solubility, microsomal stability, plasma and blood stability, plasma protein binding, permeability, CYP enzyme and transporter inhibition and substrate determination, etc.) preferred but not required. Significant Safety or Working Considerations: May work with potentially infectious samples of human and/or animal origin (i.e. blood, tissues, etc.). May handle hazardous chemicals. Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.
    $64k-102k yearly est. 19d ago
  • Research Associate

    Frontage Lab 3.9company rating

    Hayward, CA jobs

    Title: Research Associate Department: ADME Department Reports to: Group Leader - ADME Department Classification: Full-time About Us: Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials. Position/Job Summary: This position will support experiment design, data collection, analysis, troubleshooting, and data reporting within the ADME department. This includes gathering data on pre-clinical compound parameters using a variety of techniques, organizing and processing the data using statistical and analytical methods to reach meaningful conclusions, and reporting observations to clients and other decision-makers. Roles & Responsibilities: * Report to the senior team leader. * Work and collaborate daily with a group of in vitro assay biologists within the ADME department. * Learn from and teach other group members to improve skills, increase productivity, and take part in cross-training of all ADME assays. * Maintain a detailed laboratory notebook. * Develop compound methods and collect data using LC-MS/MS and other modalities (HPLC, spectrophotometry, etc.) * Conduct day-to-day testing of compounds in several cell/protein-based in vitro assays or experiments in a team-oriented environment. * Analyze and interpret data using different software programs (Sciex Analyst, DiscoveryQuant, GraphPad prism, MS Excel, etc.) * Prepare reports and communicate with collaborators and clients. * Multitask, recognize problems, provide input to solutions, draft reports, and communicate results proficiently with clients and in lab meetings. * Contribute to basic lab maintenance such as preparing buffers, cleaning, ordering, stocking, and follow-up. * Communicate and work closely with other departments to finish collaboration projects in a timely manner. * Offer drug discovery screening and IND filing support for multiple client-based projects * Other duties as assigned Education, Experience & Skills Required: * BS or MS in biology, chemistry, or related area. * 2-4 years of related experience in the biotech, pharma or preclinical CRO industry. Working experience with LC-MS/MS, HPLC, bioanalytical studies preferred. * Strong problem solving and troubleshooting skills with demonstrated ability to resolve complex situations that require a logical, analytical and methodical approach. * Self-motivated to multitask, initiate projects, and work both independently and in a team environment to meet deadlines * Excellent organization and planning skills with attention to detail. * Committed to customer satisfaction and focused on the importance of quality. * Excellent interpersonal and communication skills. * Hands-on exposure to general biotech laboratory equipment. A preferred candidate will have a good understanding and knowledge of laboratory tools, techniques, methods, and underlying principles. Work experience in cell-culture or in an in vitro ADME/DMPK lab preferred but not required. * A theoretical understanding of different ADME assays (solubility, microsomal stability, plasma and blood stability, plasma protein binding, permeability, CYP enzyme and transporter inhibition and substrate determination, etc.) preferred but not required. Significant Safety or Working Considerations: * May work with potentially infectious samples of human and/or animal origin (i.e. blood, tissues, etc.). * May handle hazardous chemicals. Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.
    $64k-102k yearly est. 60d+ ago
  • Computational Genomics Research Scientist

    Vertex Pharmaceuticals, Inc. 4.6company rating

    San Diego, CA jobs

    We are seeking a computational biologist with a strong track record of advancing biological discoveries through data analyses to join the Vertex Data and Computational Sciences (DCS) organization. In this role, you will leverage cutting‑edge computational biology to accelerate the development of transformative therapies for serious human diseases. As a member of cross-functional disease project teams, you will contribute to the development of novel therapies in areas including lung diseases and pain. You will design genomics and human genetic studies, develop and apply analytical methods, and interpret results that directly inform program strategy, target evaluation, and mechanistic understanding. You will also play a key role in innovating, evaluating, and applying state-of-the-art computational analyses to enable rapid, data-driven decisions. An independent and proactive approach, along with seamless cross-functional collaboration will be essential for success in this role. This is a San Diego based, hybrid position requiring 3 days/week onsite. Key responsibilities: * Proactively collaborate with cross‑functional project teams as the computational biology expert to identify key scientific questions that can be addressed through human genetics, genomics, sequencing, and computational analyses. * Design and execute studies across diverse omics, including bulk RNA‑seq, whole‑genome sequencing, single‑cell RNA‑seq, spatial transcriptomics, and human genetics. * Perform sophisticated computational analyses of internal and external datasets, integrating deep critical thinking, statistical rigor, domain expertise, and best practices from the literature to generate actionable insights. * Incorporate publicly available genomic resources (e.g., GTEx, gnom AD, FinnGen, UK Biobank) to contextualize and interpret internal data. * Distill complex analyses and scientific results into clear presentations, including key take-home messages and recommendations for next steps to a broad audience. * Author study reports, white papers, and manuscripts to support internal decision-making and external communications including regulatory filings. * Partner with the DCS method development team to develop innovative methods and improve usability, accuracy, and robustness of existing ones. Knowledge and Skills: * A proven track record in the analysis, visualization, and interpretation of genomic and next-generation sequencing (NGS) data * Solid scientific understanding of gene editing, the role of genetic variation in human disease, molecular biology, and cellular biology * Expertise with applying computational methods and bioinformatics tools to large-scale data * Solid understanding of statistics Education and Experience: * PhD degree (or Master's degree) in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field with 0-3 years (or 3+ years for Master's degree) of productive, relevant industry or post-doc experience. * A proven track record of stand-out excellence in the analysis, visualization, and interpretation of genomic data (such as next-generation sequencing (NGS)) or human genetic data. * Demonstrated ability to work across cross-functional teams, ensuring timely progress. * Superior communication skills, demonstrating confidence and versatility in presenting verbally to diverse audiences and writing technical documents. * Deep scientific understanding of genetic variation in human disease, molecular biology, and cellular biology. * Expertise with rapidly applying computational methods and bioinformatics tools to large-scale data. * Proficiency with R and/or python, and high-performance computing systems; solid understanding of statistics. * A team-oriented growth mindset that welcomes feedback from others and supports other team members; a positive attitude that enthusiastically tackles and overcomes challenges. #LI-KM1 #LI-Hybrid Pay Range: $112,000 - $168,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
    $112k-168k yearly Auto-Apply 8d ago
  • Computational Genomics Research Scientist

    Vertex Pharmaceuticals 4.6company rating

    San Diego, CA jobs

    We are seeking a computational biologist with a strong track record of advancing biological discoveries through data analyses to join the Vertex Data and Computational Sciences (DCS) organization. In this role, you will leverage cutting‑edge computational biology to accelerate the development of transformative therapies for serious human diseases. As a member of cross-functional disease project teams, you will contribute to the development of novel therapies in areas including lung diseases and pain. You will design genomics and human genetic studies, develop and apply analytical methods, and interpret results that directly inform program strategy, target evaluation, and mechanistic understanding. You will also play a key role in innovating, evaluating, and applying state-of-the-art computational analyses to enable rapid, data-driven decisions. An independent and proactive approach, along with seamless cross-functional collaboration will be essential for success in this role. This is a San Diego based, hybrid position requiring 3 days/week onsite. Key responsibilities: Proactively collaborate with cross‑functional project teams as the computational biology expert to identify key scientific questions that can be addressed through human genetics, genomics, sequencing, and computational analyses. Design and execute studies across diverse omics, including bulk RNA‑seq, whole‑genome sequencing, single‑cell RNA‑seq, spatial transcriptomics, and human genetics. Perform sophisticated computational analyses of internal and external datasets, integrating deep critical thinking, statistical rigor, domain expertise, and best practices from the literature to generate actionable insights. Incorporate publicly available genomic resources (e.g., GTEx, gnom AD, FinnGen, UK Biobank) to contextualize and interpret internal data. Distill complex analyses and scientific results into clear presentations, including key take-home messages and recommendations for next steps to a broad audience. Author study reports, white papers, and manuscripts to support internal decision-making and external communications including regulatory filings. Partner with the DCS method development team to develop innovative methods and improve usability, accuracy, and robustness of existing ones. Knowledge and Skills: A proven track record in the analysis, visualization, and interpretation of genomic and next-generation sequencing (NGS) data Solid scientific understanding of gene editing, the role of genetic variation in human disease, molecular biology, and cellular biology Expertise with applying computational methods and bioinformatics tools to large-scale data Solid understanding of statistics Education and Experience: PhD degree (or Master's degree) in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field with 0-3 years (or 3+ years for Master's degree) of productive, relevant industry or post-doc experience. A proven track record of stand-out excellence in the analysis, visualization, and interpretation of genomic data (such as next-generation sequencing (NGS)) or human genetic data. Demonstrated ability to work across cross-functional teams, ensuring timely progress. Superior communication skills, demonstrating confidence and versatility in presenting verbally to diverse audiences and writing technical documents. Deep scientific understanding of genetic variation in human disease, molecular biology, and cellular biology. Expertise with rapidly applying computational methods and bioinformatics tools to large-scale data. Proficiency with R and/or python, and high-performance computing systems; solid understanding of statistics. A team-oriented growth mindset that welcomes feedback from others and supports other team members; a positive attitude that enthusiastically tackles and overcomes challenges. #LI-KM1 #LI-Hybrid Pay Range: $112,000 - $168,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
    $112k-168k yearly Auto-Apply 9d ago
  • Research Scientist

    Pacific Institute for Research and Evaluation 4.2company rating

    Berkeley, CA jobs

    Requirements An advanced degree (e.g., M.D., Ph.D., J.D.) or equivalent experience At least five years experience in a relevant professional research environment. Demonstrated ability to independently develop a research program. An established record of obtaining peer-reviewed funding alone or in collaboration with others. The ability to work for any US employer.
    $99k-165k yearly est. 60d+ ago
  • Animal Research Technician (Temporary- Potential Permanent) 1

    Charles River Laboratories 4.3company rating

    Mattawan, MI jobs

    For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about. **Job Summary** We are seeking Temporary to _Potential Permanent_ Animal Research Technician at our Safety Assessment site located in Mattawan, MI. The pay for this position is $20/hour plus benefits. A Technician is responsible for assisting management, scientists, veterinarians and study related items. The technician performs basic skills independently and continues to work under supervision to gain proficiency on skills still in development. They administer substances to animals, perform husbandry duties including cleaning/transporting caging and providing food and water; perform observations of animals to determine morbidity/mortality; collect and handle data and specimens. Training Schedule: Week 1: Tuesday-Friday 8:00AM - 4:30PM Week 2+: Monday-Friday 7:00AM* - 3:30PM* _All roles and shifts require flexibility to work extended hours outside of scheduled shift based on business need, sometimes with short notice._ Potential Permanent Schedules: May vary based on business need and available roles to include: Monday - Friday with weekend and holiday rotations 07:00AM* - 3:30PM* Sunday - Thursday with holiday rotations 07:00AM* - 3:30PM* Tuesday - Saturday with holiday rotations 07:00AM* - 3:30PM* _All roles and shifts require flexibility to work extended hours outside of scheduled shift based on business need, sometimes with short notice._ Successful Candidates will possess the 6 Cs of Success: Character - Unquestionable integrity. Respect for all. Coachable - Eager to receive feedback. Open to making improvements. Commitment - Dedicated to our animals, our clients/studies, our team. Collaborative - Team player. Eager to help. Communicative - Proactively asks questions. Provide complete answers. Competent - Continuously and proactively hones and expands skill sets. **Job Qualifications** ESSENTIAL DUTIES AND RESPONSIBILITIES: + Ensure good welfare and humane care for all animals worked with through gentle, positive human animal interactions. + Train in on-boarding skills which may include animal handling, husbandry, observations, basic physiological indices, and data collection/recording to support each skill. Specific tasks will be based on each area's training plan and business needs. + Collect, document, review, and verify data on forms, or in electronic data capture systems. + Maintain appropriate communication with other personnel. + Use and maintain instrumentation and equipment according to SOPs. + Capable of repetitive gripping, pinching, lifting, carrying, pushing, and pulling. Job requires ability to independently routinely lift or carry up to 50lbs, or team lift weights exceeding 50lbs. + Ability to perform repeated twisting, bending, and reaching; exposure to hot and/or humid environments. QUALIFICATIONS: + Education: High school diploma or General Education Degree (G.E.D.), required. Bachelor's degree (BA/BS) or equivalent in a biological science, preferred. + Experience: No previous experience required. + Excellent written and verbal communication skills. + Computer skills (e.g., Microsoft Office Suite), commensurate with essential functions, including the ability to learn a validated system. + Ability to work extended hours beyond normal work schedule includes evenings, weekends, extended shifts, and/or extra shifts, sometimes on short notice. + Ability to ensure that a safe working environment is maintained observing all safety procedures and working methods by making proper use of protective clothing and equipment, and by reading, understanding, and following all safety documents issued or notified of. + Must be authorized to work in the United States without a sponsor visa, now or in the future. **About Safety Assessment** Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. **About Charles River** Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 86% of the drugs approved by the FDA in 2021. **Equal Employment Opportunity** Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_**********. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications. For more information, please visit *************** 231868
    $20 hourly Easy Apply 4d ago
  • Animal Research Technician - 2nd Shift

    Charles River Laboratories 4.3company rating

    Mattawan, MI jobs

    For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about. Job Summary We are seeking a Technician I at our Safety Assessment site located in Mattawan, MI. The pay for this position is $20/hour plus shift differential and benefits. A Technician I - Technical Operations is in training to perform and become proficient in on-boarding skills, procedures, and cooperating in a team environment. The technician is learning basic skills required to conduct a study, which may include animal handling/restraint, housing maintenance, and feeding procedures; collecting data, observing the animals for health status, and body weight measurements; administering doses by various methods, conducting euthanasia, and/or biological specimen collections for analysis. The technician is working under close supervision to gain proficiency. Successful Candidates will possess the 6 Cs of Success: Character - Unquestionable integrity. Respect for all. Coachable -Eager to receive feedback. Open to making improvements. Commitment- Dedicated to our animals, our clients/studies, our team. Collaborative - Team player. Eager to help. Communicative - Proactively asks questions. Provide complete answers. Competent - Continuously and proactively hones and expands skill sets. Job Qualifications ESSENTIAL DUTIES AND RESPONSIBILITIES: * Ensure good welfare and humane care for all animals worked with through gentle, positive human animal interactions. * Train in on-boarding skills which may include animal handling, husbandry, observations, basic physiological indices, and data collection/recording to support each skill. Specific tasks will be based on each area's training plan and business needs. * Collect, document, review, and verify data on forms, or in electronic data capture systems. * Maintain appropriate communication with other personnel. * Use and maintain instrumentation and equipment according to SOPs. * Capable of repetitive gripping, pinching, lifting, carrying, pushing, and pulling. Job requires ability to independently routinely lift or carry up to 50lbs, or team lift weights exceeding 50lbs. * Ability to perform repeated twisting, bending, and reaching; exposure to hot and/or humid environments. QUALIFICATIONS: * Education: High school diploma or General Education Degree (G.E.D.), required. Bachelor's degree (BA/BS) or equivalent in a biological science, preferred. * Experience: No previous experience required. * Excellent written and verbal communication skills. * Computer skills (e.g., Microsoft Office Suite), commensurate with essential functions, including the ability to learn a validated system. * Ability to work extended hours beyond normal work schedule includes evenings, weekends, extended shifts, and/or extra shifts, sometimes on short notice. * Ability to ensure that a safe working environment is maintained observing all safety procedures and working methods by making proper use of protective clothing and equipment, and by reading, understanding, and following all safety documents issued or notified of. * Must be authorized to work in the United States without a sponsor visa, now or in the future Competencies Lead - We lead when we advocate our purpose and model our values, when we deliver innovation, when we embrace change, and when we appreciate and celebrate the great work of others. Care - We show we care when we respect each other, our animals and the communities where we work and live, when we create a positive healthy workplace, when we are mindful of our compliance standards, and when we choose to do the right thing. Collaborate -We collaborate when we partner with each other and promote teamwork, when we communicate clearly and effectively across the hall or around the globe, and when we welcome all forms of diversity and encourage inclusiveness. Own - We act like owners when we hold ourselves accountable for our actions, when we respond to internal and external client needs with speed and accuracy, when we set and achieve meaningful goals, and when we strive towards continuous improvement. About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years. We're committed to providing benefits that elevate your quality of life. Based on your position these may include: bonus/incentives based on performance, 401K, paid time off, stock purchase program, Health and wellness coverage, employee and family wellbeing support programs, and work life balance flexibility. Equal Employment Opportunity Charles River is an equal opportunity employer and is committed to providing equal employment opportunities for all qualified applicants and employees without regard to race, color, sex, religion, national origin, ancestry, age, mental or physical disability, family status, pregnancy, military or veteran status, or any other characteristic protected by federal, state, or local laws. It is unlawful in some states (including Massachusetts) to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_**********. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications. For more information, please visit *************** 231518
    $20 hourly Easy Apply 30d ago
  • Research Associate Cell Culture & Molecular Biology

    Molecular Matrix Inc. 2.9company rating

    Rancho Cordova, CA jobs

    Job DescriptionMolecular Matrix is pioneering innovative medical devices for tissue regeneration applications in multiple organ systems. We are seeking highly motivated, self-sufficient candidates who are interested in growing with our company in a fast-paced and exciting environment. About the role: Reporting to the Research & Development Lead, the Research Associate will use cell culture and molecular biology techniques to support the development of tissue engineering medical devices. The Research Associate works primarily in R&D to support advancements in bioprocessing, scaffolding, and large-scale tissue formation. About You: You are an experienced Bachelor's or Master's level cell biologist and/or molecular biologist who enjoys collaborating across disciplines in order to solve complex problems. You are good at communicating ideas, data, and bottle-necks to technical and non-technical audiences alike. You have knowledge or interest in tissue engineering and medical devices and are excited to bring your experience and enthusiasm to this nascent industry. You thrive in fast-paced environments. Responsibilities: Perform molecular cloning: PCR, restriction digest, DNA assembly Perform gene expression assays using RT-PCR Develop new cell lines by modifying growth factor signaling Develop assays to screen, isolate, and validate cell lines Reagent preparation, aliquoting, inventory management Collaborate with the preclinical team to support preclinical trials of novel technologies Contribute to various group efforts in research and development Identify, suggest, purchase and operate supplies and equipment through established processes to support this role Mentor junior members with technical skills, and experimental design Qualifications & Skills: Experienced in adherent mammalian cell culture Experience with molecular cloning and transfection including designing DNA constructs, producing plasmids, and delivering to cells using transfection or electroporation Cell line development: able to screen, isolate, and validate targeted cell populations Knowledge of basic cell biology with an ability to develop methods to manipulate We offer great benefits (health, vision, and dental insurance and a retirement plan) and challenging, impactful work. Join our growing team, work with smart and dedicated people, and help develop cutting-edge technologies that will positively impact the world. Job Type: Full-time Salary: From $64,480.00 per year Benefits: Dental insurance Health insurance Paid time off Retirement plan Vision insurance Schedule: 8 hour shift Weekend availability Ability to commute/relocate: Rancho Cordova, CA 95670: Reliably commute or planning to relocate before starting work (Required) Education: Bachelor's (Required) Experience: Mammalian cell culture: 2 years (Required) Work Location: In person
    $64.5k yearly 7d ago
  • ADC Biologist, BioConjugation, Antibody Drug Conjugate

    Astellas Pharma, Inc. 4.9company rating

    South San Francisco, CA jobs

    Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas! Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at ***************** Purpose: Our research division is looking for a Scientist to lead bioconjugation for Antibody-Drug Conjugates (ADCs), primarily focusing on bioconjugation and ADC characteristics to drive projects in SSF. In this position, you will guide the establishment of efficient conjugation, spanning from the development of novel ADC technologies to the creation of clinical candidates. You'll work closely with relevant departments both domestically and internationally to advance our pipeline. Essential Job Responsibilities: * Actively participate in cross functional ADC projects to guide ADC discovery and development * Design and execute in vitro and in vivo assays and studies to evaluate ADC mechanism of action, potency, internalization, and payload release * Support the development and implementation of new methodologies to improve ADC screening and characterization. * Analyze, interpret, and present complex datasets to project teams and senior leadership. * Serve as an ADC Subject Matter Expert (SME), offering appropriate advice and solutions. * Develop novel ADC-related technologies and explore external technological advancements * Contribute to patents, publications, and technical reports
    $79k-111k yearly est. 35d ago
  • ADC Biologist, BioConjugation, Antibody Drug Conjugate

    Astellas Pharma 4.9company rating

    South San Francisco, CA jobs

    Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas! Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at ***************** Purpose: Our research division is looking for a Scientist to lead bioconjugation for Antibody-Drug Conjugates (ADCs), primarily focusing on bioconjugation and ADC characteristics to drive projects in SSF. In this position, you will guide the establishment of efficient conjugation, spanning from the development of novel ADC technologies to the creation of clinical candidates. You'll work closely with relevant departments both domestically and internationally to advance our pipeline. Essential Job Responsibilities: Actively participate in cross functional ADC projects to guide ADC discovery and development Design and execute in vitro and in vivo assays and studies to evaluate ADC mechanism of action, potency, internalization, and payload release Support the development and implementation of new methodologies to improve ADC screening and characterization. Analyze, interpret, and present complex datasets to project teams and senior leadership. Serve as an ADC Subject Matter Expert (SME), offering appropriate advice and solutions. Develop novel ADC-related technologies and explore external technological advancements Contribute to patents, publications, and technical reports
    $79k-111k yearly est. 6h ago
  • Research Assistant, Analytical

    Louis Dreyfus Company 4.9company rating

    Livermore, CA jobs

    Louis Dreyfus Company is a leading merchant and processor of agricultural goods. Our activities span the entire value chain from farm to fork, across a broad range of business lines, we leverage our global reach and extensive asset network to serve our customers and consumers around the world. Structured as a matrix organization of six geographical regions and ten platforms, Louis Dreyfus Company is active in over 100 countries and employs approximately 18,000 people globally. Job Description Overall Purpose and Objective of Position This role is responsible for conducting analytical testing of food materials and products, including proteins, starches, fibers, oils, and micro-analytes, following established standard operating procedures. The position involves performing both routine and advanced physicochemical and functional analyses, accurately interpreting data, and maintaining precise laboratory documentation. The individual will operate, maintain, and troubleshoot analytical instruments, ensure proper calibration, and uphold cleanliness and safety standards across all lab areas. Adherence to company safety protocols is essential. This position is a safety sensitive position and is subject to random drug testing. Primary Responsibilities/Essential Functions Understand and execute analytical tests as directed and as laid out in standard operating procedures of proteins, starch, fibers, ash, oils and various micro analytes. Perform routine and non-routine physicochemical and functional analysis of food materials and products. Analyze analytical data accurately and comprehensively. Report quality results in a timely manner and organize comprehensive laboratory records and documentation with precision. Operate, maintain and carry out basic troubleshooting of all analytical instruments and equipment. Perform instrument calibration and routine maintenance tasks as required. Keep all work areas organized and clean. Practice LDC's safety standards at all times. Qualifications Company Conformance Statements In the performance of their respective tasks and duties all employees are expected to conform to the following: Perform quality work within deadlines with or without direct supervision. Interact professionally with co-workers, Company business associates and the general public. Work together in a cooperative spirit to serve the best interests of the Company. Operate in a fully responsible manner and comply with the law and Company policy. Knowledge/Skills/Abilities (including any physical demands) Basic qualifications: A genuine desire to work in plant-based ingredients and food space. Capacity to work independently within defined experimental frame. Display of proficient bench skills. Adaptability and accountability. Analytical mindset with proven ability to gather, interpret and synthesize large volumes of data. Strong interpersonal skills and the ability to work effectively as an individual or collaborate as part of a team. Excellent verbal and written communication skills. Proficiency with spreadsheet and word-processing software (e.g., Excel, Word, PowerPoint). Strong analytical and problem-solving skills. Ability to prioritize multiple tasks to meet strict monthly deadlines. Proactively approaches job duties and potential problems. Detail oriented with strong organizational and documentation skills. Ability to provide basic maintenance to lab equipment in use. Education/Professional Certifications/Licenses Required qualification: Associate's degree in analytical chemistry, biochemistry, food science or other related field. Preferred qualifications: Bachelor's degree in analytical chemistry, biochemistry, food science or other related field. Experience Basic qualification: Prior experience working in a research laboratory Preferred qualification: Two (2) or more years of experience in a laboratory Experience in Chemistry analysis Experience in Food Research analysis Experience with LC and GC chromatography systems. Additional Information Equipment Used Centrifuge, Spectrophotometer, LC, GC, PH meters and other lab equipment. Typical office equipment: PC, printer/scanner. Working Conditions Time split between pilot plant, office and lab environments. There may be extended periods of sitting or standing at a computer screen or counter. Interacts closely with personnel in other departments and Company locations. Interacts closely with middle and senior management personnel. Extensions of regular working hours are occasionally necessary to complete time-sensitive projects or to respond to emergencies. Employee Supervision No employee supervision. Decision Making/Accountability Prioritizing workload to ensure deadlines are met and communicating updates with management and other departments. What We Offer We provide a dynamic and stimulating international environment, which will stretch and develop your abilities and channel your skills and expertise with outstanding career development opportunities in one of the largest and most solid private companies in the world. - Comprehensive benefits program including medical, dental and vision care coverage, flexible spending account plans, employee assistance program, life insurance and disability coverage - 401k with Company Match - Family Friendly Benefits including childbirth and parental leave, fertility and family building benefits - Paid Time Off (PTO) and Paid Holidays - Flexible work available (not applicable to all roles) Diversity & Inclusion LDC is driven by a set of shared values and high ethical standards, with diversity and inclusion being part of our DNA. LDC is an equal opportunity employer committed to providing a working environment that embraces and values diversity, equity and inclusion. LDC encourages diversity, supports local communities and environmental initiatives. We encourage people of all backgrounds to apply. Equal employment opportunity (EEO) Louis Dreyfus Company provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training. Sustainability Sustainable value is at the heart of our purpose as a company. We are passionate about creating fair and sustainable value, both for our business and for other value chain stakeholders: our people, our business partners, the communities we touch and the environment around us
    $41k-62k yearly est. 23h ago
  • Research Assistant, Analytical

    Louis Dreyfus Company 4.9company rating

    Livermore, CA jobs

    Louis Dreyfus Company is a leading merchant and processor of agricultural goods. Our activities span the entire value chain from farm to fork, across a broad range of business lines, we leverage our global reach and extensive asset network to serve our customers and consumers around the world. Structured as a matrix organization of six geographical regions and ten platforms, Louis Dreyfus Company is active in over 100 countries and employs approximately 18,000 people globally. Job Description Overall Purpose and Objective of Position This role is responsible for conducting analytical testing of food materials and products, including proteins, starches, fibers, oils, and micro-analytes, following established standard operating procedures. The position involves performing both routine and advanced physicochemical and functional analyses, accurately interpreting data, and maintaining precise laboratory documentation. The individual will operate, maintain, and troubleshoot analytical instruments, ensure proper calibration, and uphold cleanliness and safety standards across all lab areas. Adherence to company safety protocols is essential. This position is a safety sensitive position and is subject to random drug testing. Primary Responsibilities/Essential Functions * Understand and execute analytical tests as directed and as laid out in standard operating procedures of proteins, starch, fibers, ash, oils and various micro analytes. * Perform routine and non-routine physicochemical and functional analysis of food materials and products. Analyze analytical data accurately and comprehensively. * Report quality results in a timely manner and organize comprehensive laboratory records and documentation with precision. * Operate, maintain and carry out basic troubleshooting of all analytical instruments and equipment. Perform instrument calibration and routine maintenance tasks as required. * Keep all work areas organized and clean. * Practice LDC's safety standards at all times. Qualifications Company Conformance Statements In the performance of their respective tasks and duties all employees are expected to conform to the following: * Perform quality work within deadlines with or without direct supervision. * Interact professionally with co-workers, Company business associates and the general public. * Work together in a cooperative spirit to serve the best interests of the Company. * Operate in a fully responsible manner and comply with the law and Company policy. Knowledge/Skills/Abilities (including any physical demands) Basic qualifications: * A genuine desire to work in plant-based ingredients and food space. * Capacity to work independently within defined experimental frame. * Display of proficient bench skills. * Adaptability and accountability. * Analytical mindset with proven ability to gather, interpret and synthesize large volumes of data. * Strong interpersonal skills and the ability to work effectively as an individual or collaborate as part of a team. * Excellent verbal and written communication skills. * Proficiency with spreadsheet and word-processing software (e.g., Excel, Word, PowerPoint). * Strong analytical and problem-solving skills. * Ability to prioritize multiple tasks to meet strict monthly deadlines. * Proactively approaches job duties and potential problems. * Detail oriented with strong organizational and documentation skills. * Ability to provide basic maintenance to lab equipment in use. Education/Professional Certifications/Licenses Required qualification: * Associate's degree in analytical chemistry, biochemistry, food science or other related field. Preferred qualifications: * Bachelor's degree in analytical chemistry, biochemistry, food science or other related field. Experience Basic qualification: * Prior experience working in a research laboratory * Preferred qualification: * Two (2) or more years of experience in a laboratory * Experience in Chemistry analysis * Experience in Food Research analysis * Experience with LC and GC chromatography systems. Additional Information Equipment Used * Centrifuge, Spectrophotometer, LC, GC, PH meters and other lab equipment. * Typical office equipment: PC, printer/scanner. Working Conditions * Time split between pilot plant, office and lab environments. There may be extended periods of sitting or standing at a computer screen or counter. * Interacts closely with personnel in other departments and Company locations. * Interacts closely with middle and senior management personnel. * Extensions of regular working hours are occasionally necessary to complete time-sensitive projects or to respond to emergencies. Employee Supervision * No employee supervision. Decision Making/Accountability * Prioritizing workload to ensure deadlines are met and communicating updates with management and other departments. What We Offer We provide a dynamic and stimulating international environment, which will stretch and develop your abilities and channel your skills and expertise with outstanding career development opportunities in one of the largest and most solid private companies in the world. * Comprehensive benefits program including medical, dental and vision care coverage, flexible spending account plans, employee assistance program, life insurance and disability coverage * 401k with Company Match * Family Friendly Benefits including childbirth and parental leave, fertility and family building benefits * Paid Time Off (PTO) and Paid Holidays * Flexible work available (not applicable to all roles) Diversity & Inclusion LDC is driven by a set of shared values and high ethical standards, with diversity and inclusion being part of our DNA. LDC is an equal opportunity employer committed to providing a working environment that embraces and values diversity, equity and inclusion. LDC encourages diversity, supports local communities and environmental initiatives. We encourage people of all backgrounds to apply. Equal employment opportunity (EEO) Louis Dreyfus Company provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training. Sustainability Sustainable value is at the heart of our purpose as a company. We are passionate about creating fair and sustainable value, both for our business and for other value chain stakeholders: our people, our business partners, the communities we touch and the environment around us
    $41k-62k yearly est. 13d ago
  • Research Chemist (E&L)

    Nivagen Pharmaceuticals 3.7company rating

    Sacramento, CA jobs

    About the Company: Nivagen is a global company dedicated to enhancing lives by developing and providing cost-effective generic prescription drugs and over-the-counter products for the North American market. For over a decade, we've remained steadfast in our commitment to the core values of excellence, integrity, and respect for people. Our team of professionals collaborates tirelessly to pioneer advancements in manufacturing, distribution, and quality control, ensuring a holistic approach to healthcare. Through vertical integration of the pharmaceutical supply chain, cutting-edge technology, and unwavering dedication to excellence, we continually strive to redefine medication accessibility and affordability. We prioritize our employees' well-being by offering competitive pay, comprehensive benefits, and robust training and development opportunities. By investing in our workforce and fostering a culture of growth and support, we empower our team to drive innovation and make a positive impact in the healthcare industry. At Nivagen, our mission is clear: to make a meaningful difference in people's lives by delivering high-quality, affordable medications while upholding the highest standards of integrity and excellence. Job Location: Nivagen Pharmaceuticals Inc., Sacramento, CA 3900 Duckhorn Dr, Sacramento, CA 95834 About the Job: Title of the Position: Research Chemist (E&L) We are seeking an experienced Research Chemist (E&L) with a minimum of 3-5 years of pharmaceutical industry experience. Responsibilities: Maintain, operate, and troubleshoot LC-MS and GC-MS, GC-FID, and ICP-MS Systems. Perform extraction, analysis, and characterization of extractables and leachables from polymeric materials associated with container closure systems of pharmaceutical drug products as per USP, PQRI, ICH and other regulatory guidelines. Develop and optimize sample preparation techniques for analysis on GC-MS, LC-MS, and ICP-MS systems. Develop and validate LC-MS, GC-MS, and ICP-MS methods for finished product and raw material characterization as well as extractable/leachable testing. Unknown impurity identifications using GC-MS, LC-MS, and LC-MS/MS or other suitable techniques. Interpret complex spectral data and fragmentation patterns. Routine stability testing of API, finished product samples for assay and impurities using various instrumental techniques as suited, and prepare stability data summaries. Generate study designs, write protocols, methods, Datasheets and reports. Provide support in the critical review of analytical data, reports and protocols. Write Instrument-related SOPs and provide training on the instrument and related software. Train new recruits in the lab and support the team as needed. Participate in internal meetings and conferences. Provide support during technical transfer between R&D and QC. Whenever needed, attend SOP, Safety, and scientific trainings to remain current with cGMP regulations, safety standards, and development technologies. Preparation and review of analytical methods, method validation, and related study reports for ANDA/ NDA submissions and support, document preparation for ANDA/ NDA submissions. Any other activities as directed by the supervisor. Qualifications: Education/Experience: Bachelor's or Master's degree in Chemistry, Pharmaceutical Sciences, Biochemistry, or a related field. Knowledge, Skills, and Abilities: Familiarity with the characterization and isolation of impurities. Strong foundation in organic chemistry and structural elucidation, with expertise in small molecule pharmaceutical drug development and peptides, including computational techniques. Proficiency in using standard laboratory equipment, including pipettes, graduated cylinders, and balances. Skilled in laboratory techniques for measuring, weighing, and handling samples. Hands-on experience with HPLC (highly preferred). Knowledge of chemical handling procedures, including safety precautions and documentation such as Safety Data Sheets (SDS). Competency in Microsoft Office applications. Experience or familiarity with current Good Manufacturing Practices (cGMP) is preferred. Requirements: Must live or be willing to move to the Sacramento Metropolitan Region (Approximately 40 miles' radius) Benefits: Pay range $70,000 - $85,000 per Year Yearly bonus eligibility Benefits: Nivagen offers a wide variety of benefits and programs to support health and well-being Medical, dental and vision coverage Paid time off plan 401 (k) savings plan Additional Information: Nivagen to afford equal opportunity for employment to all individuals regardless of race, color, age, national origin, physical or mental disability, history of disability, ancestry, citizenship status, political affiliation, religion, gender, transgender, gender identity, marital status, status as a parent, sexual orientation, veteran status, genetic information or other factors prohibited by law, and to prohibit harassment o retaliation based on any of these factors.
    $70k-85k yearly Auto-Apply 36d ago
  • Research Chemist (E&L)

    Nivagen Pharmaceuticals 3.7company rating

    Sacramento, CA jobs

    Job Description About the Company: Nivagen is a global company dedicated to enhancing lives by developing and providing cost-effective generic prescription drugs and over-the-counter products for the North American market. For over a decade, we've remained steadfast in our commitment to the core values of excellence, integrity, and respect for people. Our team of professionals collaborates tirelessly to pioneer advancements in manufacturing, distribution, and quality control, ensuring a holistic approach to healthcare. Through vertical integration of the pharmaceutical supply chain, cutting-edge technology, and unwavering dedication to excellence, we continually strive to redefine medication accessibility and affordability. We prioritize our employees' well-being by offering competitive pay, comprehensive benefits, and robust training and development opportunities. By investing in our workforce and fostering a culture of growth and support, we empower our team to drive innovation and make a positive impact in the healthcare industry. At Nivagen, our mission is clear: to make a meaningful difference in people's lives by delivering high-quality, affordable medications while upholding the highest standards of integrity and excellence. Job Location: Nivagen Pharmaceuticals Inc., Sacramento, CA 3900 Duckhorn Dr, Sacramento, CA 95834 About the Job: Title of the Position: Research Chemist (E&L) We are seeking an experienced Research Chemist (E&L) with a minimum of 3-5 years of pharmaceutical industry experience. Responsibilities: Maintain, operate, and troubleshoot LC-MS and GC-MS, GC-FID, and ICP-MS Systems. Perform extraction, analysis, and characterization of extractables and leachables from polymeric materials associated with container closure systems of pharmaceutical drug products as per USP, PQRI, ICH and other regulatory guidelines. Develop and optimize sample preparation techniques for analysis on GC-MS, LC-MS, and ICP-MS systems. Develop and validate LC-MS, GC-MS, and ICP-MS methods for finished product and raw material characterization as well as extractable/leachable testing. Unknown impurity identifications using GC-MS, LC-MS, and LC-MS/MS or other suitable techniques. Interpret complex spectral data and fragmentation patterns. Routine stability testing of API, finished product samples for assay and impurities using various instrumental techniques as suited, and prepare stability data summaries. Generate study designs, write protocols, methods, Datasheets and reports. Provide support in the critical review of analytical data, reports and protocols. Write Instrument-related SOPs and provide training on the instrument and related software. Train new recruits in the lab and support the team as needed. Participate in internal meetings and conferences. Provide support during technical transfer between R&D and QC. Whenever needed, attend SOP, Safety, and scientific trainings to remain current with cGMP regulations, safety standards, and development technologies. Preparation and review of analytical methods, method validation, and related study reports for ANDA/ NDA submissions and support, document preparation for ANDA/ NDA submissions. Any other activities as directed by the supervisor. Qualifications: Education/Experience: Bachelor's or Master's degree in Chemistry, Pharmaceutical Sciences, Biochemistry, or a related field. Knowledge, Skills, and Abilities: Familiarity with the characterization and isolation of impurities. Strong foundation in organic chemistry and structural elucidation, with expertise in small molecule pharmaceutical drug development and peptides, including computational techniques. Proficiency in using standard laboratory equipment, including pipettes, graduated cylinders, and balances. Skilled in laboratory techniques for measuring, weighing, and handling samples. Hands-on experience with HPLC (highly preferred). Knowledge of chemical handling procedures, including safety precautions and documentation such as Safety Data Sheets (SDS). Competency in Microsoft Office applications. Experience or familiarity with current Good Manufacturing Practices (cGMP) is preferred. Requirements: Must live or be willing to move to the Sacramento Metropolitan Region (Approximately 40 miles' radius) Benefits: Pay range $70,000 - $85,000 per Year Yearly bonus eligibility Benefits: Nivagen offers a wide variety of benefits and programs to support health and well-being Medical, dental and vision coverage Paid time off plan 401 (k) savings plan Additional Information: Nivagen to afford equal opportunity for employment to all individuals regardless of race, color, age, national origin, physical or mental disability, history of disability, ancestry, citizenship status, political affiliation, religion, gender, transgender, gender identity, marital status, status as a parent, sexual orientation, veteran status, genetic information or other factors prohibited by law, and to prohibit harassment o retaliation based on any of these factors.
    $70k-85k yearly 6d ago
  • Biologist

    Zoetis 4.9company rating

    Kalamazoo, MI jobs

    Zoetis is seeking a Biologist to join our Clinical Pharmacology group and support research in animal models of disease-including allergy/dermatitis, pain, and inflammation. This role involves hands-on in vivo work, study design, and cross-functional collaboration in a dynamic veterinary medicine research environment. Key Responsibilities Conduct in vivo studies using animal models of disease (allergy, dermatitis, pain, inflammation, etc.). Work directly with dogs, cats, rodents, and other species as needed. Perform animal procedures including: Blood sampling Dosing via multiple routes (IV, SC, oral, etc.) Basic behavioral training for simple tasks Contribute to disease model development and support early-stage drug discovery. Prepare and assist in writing animal use protocols and ensure compliance with ethical and regulatory standards. Design, execute, interpret, and report findings from in vivo studies. Collaborate closely within a team of in vivo biologists; lead assigned research areas or sub-projects. Communicate scientific results clearly to diverse audiences across a matrixed R&D environment. Support planning and logistics for complex, multi-phase studies. Basic Requirements: BS in Biological Sciences, Animal Science, or related field 3+ years of hands-on experience working with animals in a research setting. Preferred Qualifications: Proven experience handling rodents, cats, and dogs, including blood collection and compound administration Experience developing in vivo disease models (rodents or larger species). Background in in vivo drug discovery, including target identification and validation. Ability to independently direct scientific research and lead sub-projects. Practical experience preparing IACUC or equivalent animal use protocols. Strong planning and organizational skills for managing complex study designs. Demonstrated ability to collaborate across scientific functions and consider multiple scenarios during study planning. Attributes & Competencies High enthusiasm for science and animal health research. Creativity, flexibility, and adaptability in a fast-moving research environment. Strong interpersonal and communication skills. Track record of generating innovative solutions to research challenges. Ability to thrive in a matrixed organizational structure. Full time RegularColleague Any unsolicited resumes sent to Zoetis from a third party, such as an Agency recruiter, including unsolicited resumes sent to a Zoetis mailing address, fax machine or email address, directly to Zoetis employees, or to Zoetis resume database will be considered Zoetis property. Zoetis will NOT pay a fee for any placement resulting from the receipt of an unsolicited resume. Zoetis will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees. This includes any Agency that is an approved/engaged vendor but does not have the appropriate approvals to be engaged on a search. Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at ********************************** to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at ********************** site, or (2) via email to/from addresses using only the Zoetis domain of “@zoetis.com”. In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.
    $63k-80k yearly est. Auto-Apply 47d ago

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