Relay Therapeutics jobs in Cambridge, MA - 3674 jobs

The Opportunity: As Clinical Project Manager, you will be accountable for managing clinical studies that will lead the biopharma industry in speed and quality of clinical study design and execution. You will be an integrated member of the Relay Tx scientific team, responsible for the execution of clinical studies that will translate Relay's innovative science into impactful medicines for patients. The Role: You will oversee the day-to-day operations of study execution, with a focus on site oversight from study startup to study closeout, patient enrollment, monitoring, compliance, and data flow and metrics from the clinical sites, CROs and vendors. You will collaborate with a dynamic Relay cross-functional team to deliver clinical studies that are on time and within budget guidelines, while ensuring quality in accordance with the protocol and ICH GCP guidelines. You will develop and maintain strong relationships with investigators, clinical site staff, and vendors globally, with the capability of understanding and explaining complex scientific topics to these stakeholders. You will manage reports for communicating study progress and key metrics to Senior Management and program teams. You will contribute to or author key study documents including, but not limited to, protocols, informed consent forms, case report forms, study governance committee charters (e.g., data monitoring committee), study plans and clinical study reports. You will be accountable for effective vendor management by: serving as primary point of contact for contracted CROs and vendors identifying potential risks and proactively resolving issues with CROs and vendors ensuring vendor contracts meet requirements and are efficiently executed with key performance indicators partnering with the vendor to ensure accurate budgeting and accrual of costs throughout duration of each clinical study You will ensure reliable quality data are delivered by reviewing monitoring reports, protocol deviations, clinical data listings and performing or overseeing site monitoring visits, as needed. You will develop action plans to address protocol compliance, safety, data and administrative issues with clinical sites and CROs. You will coordinate with CROs on site selection, IRB/EC submissions, site initiation and close-out planning. You will provide oversight and ensure maintenance of clinical trial master files (TMF) to ensure compliance with required regulatory and ICH GCP quality standards and consistency with SOPs. You will partner with the CRO to lead, plan, and execute clinical Investigator meetings study meetings, as needed. You and your team will participate in preparation of regulatory filings (e.g. IND, NDA, orphan drug applications etc.) as needed. You will ensure inspection readiness by collaborating with CROs and providing support to clinical sites to prepare for and respond to audit/inspection findings conducted by internal QA and external regulatory agencies. You will assist with the onboarding and mentoring of new or junior clinical operations associates. Your Background: You should ideally have 5+ years of experience in clinical study management. Sponsor experience is strongly preferred. You are recognized as a clinical operations expert, with a prior track record of success to facilitate study execution, accelerate timelines, maintain data integrity, and satisfy health authority requirements. You have experience in executing clinical studies across various phases is desirable. Expertise in oncology drug development is preferred. You have a strong and current knowledge in global regulatory and compliance requirements including but not limited to US CFR, EU CTD, and ICH GCP applicable to the conduct of clinical trials You have experience in CRO, vendor and laboratory oversight. You are a motivated self-starter who is capable of flourishing in a fast-paced small company environment. You are a creative problem-solver with excellent communication and public speaking skills. You have strong interpersonal and organizational skills, with a high degree of attention to detail. You are pragmatic and able to manage multiple projects and needs effectively. Estimated Salary Range: [$102,000 - $145,000]. The range provided above is based on what we believe to be a reasonable estimate for this job at the time of posting. Actual base salary will depend on a number of factors, including but not limited to, a candidate's education, experience, skills and location. #JO1 About Relay Therapeutics Relay Therapeutics is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process. Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. If you're excited by the challenge of putting protein motion at the heart of drug discovery and passionate about making a difference in the lives of patients, join us!

The ECMO Specialist is enrolled and actively participating in the department's ECMO Training Program. This role is responsible for developing and maintaining the skills necessary to proficiently and safely establish, manage, and control extracorporeal membrane oxygenation (ECMO) technology and assist with associated procedures in acutely ill patients of all ages in critical care settings. The specialist will learn to troubleshoot devices and associated equipment under the supervision of experienced ECMO personnel, provide ongoing care through surveillance of clinical and physiologic parameters, adjust ECLS devices as needed, administer and document blood products and medications in accordance with hospital standards, provide airway and ventilator management, and perform the full scope of practice of a Respiratory Therapist II. Schedule: 36 hours per week, rotating day/night shifts, every third weekend. **This position is eligible for full time benefits $20,000 sign-on bonus (not eligible for internal candidates and not eligible for former BCH employees who worked here in the past 2 years) Key Responsibilities: Assemble, prepare, and maintain extracorporeal circuits and associated equipment with assistance. Assist in priming extracorporeal circuits and preparing systems for clinical application. Assist with cannulation procedures. Assist in establishing extracorporeal support; monitor patient response, provide routine assessments, circuit evaluations, patient monitoring, and anticoagulation management. Assist with ECMO circuit interventions, weaning procedures, and transports. Administer blood products per hospital standards. Interact and communicate with caregivers, nursing, surgical and medical teams, patients, and family members. Maintain relevant clinical documentation in the patient's electronic health record. Participate in professional development, simulation, and continuing education. Attend ECMO Team meetings and M&M conferences on a regular basis. Minimum Qualifications Education: Required: Associate's Degree in Respiratory Therapy Preferred: Bachelor's Degree Experience: Required: A minimum of one year of experience as a BCH Respiratory Therapist with eligibility for promotion to RT II, or one year of external ECMO experience Preferred: None specified Licensure / Certifications: Required: Current Massachusetts license as a Respiratory Therapist Required: Current credential by the National Board of Respiratory Care as a Registered Respiratory Therapist (RRT); Neonatal Pediatric Specialist (NPS) credential must be obtained within 6 months of entry into the role Preferred: None specified The posted pay range is Boston Children's reasonable and good-faith expectation for this pay at the time of posting. Any base pay offer provided depends on skills, experience, education, certifications, and a variety of other job-related factors. Base pay is one part of a comprehensive benefits package that includes flexible schedules, affordable health, vision and dental insurance, child care and student loan subsidies, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition and certain License and Certification Reimbursement, cell phone plan discounts and discounted rates on T-passes. Experience the benefits of passion and teamwork.

About Tufts Medicine Tufts Medicine is an innovative, mission-driven health system that unites the best of academic and community medicine to deliver exceptional, connected, and accessible care. Our system includes Tufts Medical Center, the principal teaching hospital of Tufts University and Tufts University School of Medicine, as well as Lowell General Hospital, Lowell General Hospital - Saints Campus, MelroseWakefield Hospital, Lawrence Memorial Hospital of Medford, Tufts Medicine Behavioral Health Hospital (opening Fall 2025), Tufts Medicine Care at Home, Tufts Medicine Integrated Network, and a network of 2,300 physicians across Massachusetts and southern New Hampshire. We treat the most complex conditions, keep our communities healthy, and bring research breakthroughs to life. Onsite at Tufts Medical Center Boston, MA. Job Overview This position serves as a strategic partner in advancing the academic and research missions across Tufts Medicine (TM), Tufts University School of Medicine (TUSM), and Tufts Medical Center (TMC). Responsible to align and oversee funds flow across the academic enterprises, implement efficiencies in current processes, and establish standardized sponsored fund accounting structures across the health system. Collaborate with academic, research, and clinical leaders to ensure fiscal accountability, regulatory compliance, and long-term sustainability of academic and research priorities. Job Description Minimum Qualifications: 1. Bachelor's degree in Accounting, Finance, Business Administration, or related field. 2. Fifteen (15) years of progressive financial management experience, including leadership in a complex academic healthcare environment, research and education, budget development, funds flow, and sponsored program financial management. Preferred Qualifications: 1. Master's degree in related field. 2. CPA, CMA, or CFA credential. 3. Experience in an Academic Medical Center, medical school, or integrated health system. 4. Experience with research finance, philanthropy finance, and academic budgeting (UME, GME, endowed positions, faculty appointments). 5. Experience with federal funding structures, e.g., CTSI funding, NIH funding mitigation strategies, and federal indirect cost/F&A structures. Duties and Responsibilities: The duties and responsibilities listed below are intended to describe the general nature of work and are not intended to be an all-inclusive list. Other duties and responsibilities may be assigned. 1. Oversee and integrate the research and education (academic) budgets across TM and TMC. 2. Support budget development and ongoing management of Dean/CAO office budgets, incorporating research, Undergraduate Medical Education (UME), Graduate Medical Education (GME), and faculty development. 3. Support execution of Tufts Medicine-Tufts University research priorities, including CTSI, research/education initiatives, and cluster hire funding. 4. Provide strategic oversight for research funds flow, including clinical trials (central vs. departmental models). 5. Direct funds flow between TM/TMC and TUSM, to support the research and education mission, including support for research infrastructure, shared services, educational roles including site directors, joint appointments, per-student fees, and named positions (e.g., coaches, clerkship directors). 6. Oversee faculty funding streams including endowed professorships, directorships, and joint appointments. 7. Lead development, review, and updates to research and special fund financial policies in alignment with system priorities and federal guidelines. 8. Develop financial models for NIH/F&A funding decreases and lead F&A Joint Allocation Group (JAG) processes. 9. Drive Medicare cost report optimization to maximize education-related reimbursements. 10. Support educational agreements between Tufts Medicine, TUSM, and partner institutions (including Children's Hospital). 11. Manage resident funding, and expansion planning at Lowell, Melrose, and future sites. 12. Develop and implement funds flow models that balance academic incentives with strategic investment in system-wide research and education. 13. Establish infrastructure for research and philanthropic fund accounting across the system, including F&A assessment and allocation. 14. Oversee sundry fund management and philanthropic fund compliance, ensuring optimal utilization and alignment with institutional goals. 15. Partner with TU and internal stakeholders to establish policies and processes for research and education philanthropy. 16. Ensure compliance, maximize resource utilization, and align philanthropic funding with academic and research priorities. Physical Requirements: 1. This is largely a sedentary role, which involves sitting most of the time, but may involve movements such as walking, standing, reaching, ascending/descending stairs, and operating office equipment. 2. Frequently required to speak, hear, communicate, and exchange information. 3. Ability to see and read computer displays, read fine print, and/or normal type size print and distinguish letters, numbers and symbols. 4. Requires manual dexterity using fine hand manipulation to operate computer keyboard. Skills & Abilities: 1. Strong leadership and team management skills and the ability to direct senior-level staff. 2. Deep knowledge of academic and research finance within a healthcare system. 3. Strong knowledge and understanding of federal research and academic funding regulations and funding mechanisms (e.g., NIH, Medicare cost reporting). 3. Strategic thinker with ability to design sustainable funds flow and financial models. 4. Excellent communication and interpersonal skills and the ability to influence stakeholders at all levels. 5. Analytical and problem-solving skills and ability to improve processes. 6. Ability to navigate a complex, matrixed organization with competing priorities. Job Profile Summary This role focuses on performing a variety of financial activities, including accounting, financial analysis, audit, tax, and collections, while ensuring compliance with regulatory standards. In addition, this role focuses on performing the following Finance Leadership duties: Controls, directs, and participates in the activities of the organization through a hierarchy of managers and supervisors. Responsibilities also include long-term strategic planning, determining the policies of the organization, and allocating its resources and making decisions regarding organization growth and diversification to accomplish entity's vision. A management role that supervises employees focusing on tactical, operational activities within a specified area, with the majority of time spent overseeing area of responsibility, planning, prioritizing and/or directing the responsibilities of employees. Goal achievement is typically accomplished through performance of direct and/or indirect reports. A role that manages experienced professionals who exercise latitude and independence in assignments. Responsibilities typically include: policy and strategy implementation for short-term results (1 year or less), problems faced are difficult to moderately complex, and influences others outside of own job area regarding policies, practices and procedures. At Tufts Medicine, we want every individual to feel valued for the skills and experience they bring. Our compensation philosophy is designed to offer fair, competitive pay that attracts, retains, and motivates highly talented individuals, while rewarding the important work you do every day. The base pay ranges reflect the minimum qualifications for the role. Individual offers are determined using a comprehensive approach that considers relevant experience, certifications, education, skills, and internal equity to ensure compensation is fair, consistent, and aligned with our business goals. Beyond base pay, Tufts Medicine provides a comprehensive Total Rewards package that supports your health, financial security, and career growth-one of the many ways we invest in you so you can thrive both at work and outside of it. Pay Range: $162,773.52 - $207,541.52

Facilities Management Director Career Opportunity Acknowledged and Appreciated for your expertise in Facility Management Are you an experienced Facilities Management Director with a passion for improving healthcare environments? Encompass Health, the largest in-patient rehabilitation company in the nation, offers careers that are close to both home and heart. In this role, you will play a crucial part in ensuring the smooth and safe operation of our hospital, creating a welcoming and healing atmosphere for patients and their families. If you excel in managing, maintaining, and transforming facilities into warm, inviting spaces that prioritize patient comfort and community, we have an exciting opportunity for you. Join us in a role where you will ensure your rehabilitation hospital meets regulatory standards and fosters an environment centered on patient safety and care. A Glimpse into Our World At Encompass Health, you'll experience the difference the moment you become a part of our team. Being at Encompass Health means aligning with a rapidly growing national inpatient rehabilitation leader. We take pride in the growth opportunities we offer and how our team unites for the greater good of our patients. Our achievements include being named one of the "World's Most Admired Companies" and receiving the Fortune 100 Best Companies to Work For Award, among other accolades, which is nothing short of amazing. Starting Perks and Benefits At Encompass Health, we are committed to creating a supportive, inclusive, and caring environment where you can thrive. From day one, you will have access to: Affordable medical, dental, and vision plans for both full-time and part-time employees and their families. Generous paid time off that accrues over time. Opportunities for tuition reimbursement and continuing education. Company-matching 401(k) and employee stock purchase plans. Flexible spending and health savings accounts. A vibrant community of individuals passionate about the work they do! Become the Facilities Management Director you've always aspired to be Ensuring that the rehabilitation hospital, satellite clinics, and all related building systems adhere to Joint Commission standards, as well as local, state, and federal regulatory requirements. Planning and leading environment of care/safety meetings, with potential responsibilities as the safety officer in charge of compliance. Coordinating and overseeing preventive and corrective maintenance programs in alignment with industry standards and equipment manufacturer recommendations. Cultivating and maintaining an inclusive work environment and culture that embraces diversity. Qualifications A Bachelor's degree and/or five or more years of experience in hospital maintenance and/or construction within a healthcare setting are required. A minimum of five years of supervisory experience in healthcare-related facility equipment and systems operations, including expertise in chiller systems, steam boilers, hydraulic systems, building controls, electrical systems, and air handlers. Broad knowledge of TJC, OSHA, EPA, NFPA, and other federal, state, and local regulatory agency standards is essential. Membership in a state or national healthcare engineering association is preferred. Preferred: Certified Healthcare Facility Manager (CHFM). A valid driver's license is a prerequisite. May be required to work weekdays and/or weekends, evenings and/or night shifts. May be required to work on religious and/or legal holidays on scheduled days/shifts. We're looking forward to meeting you, and we genuinely mean that. Join us on this remarkable journey!

Hey there! Looking for a rewarding opportunity in healthcare staffing? VieMed Healthcare Staffing is here to help you make your next career move! We're all about quality, reliability, and integrity, ensuring both our candidates and clients receive top-notch service. Join us in our mission to elevate healthcare staffing to new heights. We've got your back, so you can focus on taking care of others. Responsibilities City: Lawrence State: MA Start Date: 2024-12-23 End Date: 2025-03-22 Duration: 13 Weeks Shift: Day shift Skills: N/A W2 Pay Rate: $77.55 *Travel and Local Rates available Certification Requirements: Please confirm credential requirements with VHS upon application. At VieMed, "Live Your Life" isn't just a tagline - it's our commitment to improving the lives of every patient and employee. Benefits Include: Competitive Pay Packages Weekly Pay Schedule via Direct Deposit Comprehensive Medical Benefits Dental and Vision Supplemental Benefits 401(k) with match Robust Referral Bonus Program 24/7 Dedicated team committed to your success throughout your time with VHS Paid sick time in accordance with all applicable state, federal and local laws Licensure, certification, travel and other reimbursements when applicable VHS is an Equal Opportunity Employer ("EEO")/Protected Veterans/Individuals with Disabilities/E-Verify Employer and welcomes all to apply #LiveYourLife For more jobs like this, check out PhysicianWork.com.

Title:- Scientist I Duration: Contract until Jan 2027 (Two-year assignment with possibility to convert depends on performance and project needs) COVID VAX IS REQUIRED PRIOR TO STARTING Description: The Cell Line Development Department at *** is seeking a highly motivated Molecular Biology Scientist to join a high-performing, collaborative team focused on optimizing CHO cell line development platforms through advanced molecular biology techniques and automation. Responsibilities will focus on improving process workflows, expression system components, and CLD methods used to generate recombinant CHO cell lines for production of protein biologics. This will include the design and generation of next generation vector topologies utilizing modern cloning strategies such as Gibson assembly and Golden Gate cloning. The ideal candidate will possess expertise in high-throughput molecular biology workflows and automated vector construction pipelines. Work will directly support development projects in ***'s pipeline and will include frequent cross-functional interactions with colleagues in ***'s global CMC sites (US, France). Key Responsibilities • Design and construct expression vectors using advanced molecular cloning techniques including Gibson assembly, Golden Gate cloning, restriction enzyme-based cloning, and site-directed mutagenesis • Develop, optimize, and implement automated workflows for high-throughput vector construction and DNA assembly on liquid handling platforms • Generate, validate, and bank vector constructs for expression of candidate biotherapeutic molecules in mammalian cell systems • Perform molecular characterization of cell lines and constructs using techniques such as dd PCR, Sanger sequencing, and restriction mapping • Support NGS library preparation for genomic and transcriptomic analysis of CHO cell lines • Optimize and troubleshoot molecular biology protocols to improve efficiency and reproducibility • Prepare technical reports and presentations to communicate progress and data Basic Qualifications • PhD (0-3 years) in Molecular Biology, Cell Biology, Biochemistry, Bioengineering, or related discipline • Extensive hands-on experience with molecular cloning techniques including Gibson assembly, Golden Gate cloning, restriction cloning, and PCR-based methods • Demonstrated expertise in DNA construct design, vector engineering, and plasmid preparation • Experience with genetic characterization methods such as dd PCR, qPCR, gel electrophoresis, and DNA sequencing analysis • Proficiency in designing and optimizing molecular biology workflows for automation on liquid handling platforms (Hamilton, Tecan, or similar) • Strong technical background in molecular biology with excellent attention to detail and troubleshooting skills • Self-motivated with excellent organization, time-management, and communication skills • Maintain detailed electronic laboratory notebooks and documentation of all experimental procedures • Demonstrated ability to work as member of a team and adhere to timelines Preferred Qualifications • Mammalian cell culture experience in a pharmaceutical or biotechnology setting, particularly with CHO cells • Experience with high-throughput screening and clone selection strategies • Familiarity with bioinformatic tools for DNA sequence analysis, primer design, and in silico cloning (Snapgene, Geneious, Benchling, Primer3 or similar) • Knowledge of CHO cell line development processes and recombinant protein expression • Experience using Oxford Nanopore Technologies in NGS workflows • Basic programming skills in R or Python for data analysis and visualization • Experience with Bash/command line scripting for bioinformatics workflows and data processing • Experience with automated colony picking and clone tracking systems • Flexibility to adjust to a fast-paced, goal-oriented environment and willingness to expand and broaden skillset As a healthcare company and a vaccine manufacturer, *** has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities. According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pharmaceutical vaccine, or (b) the single dose of the Pharmaceutical vaccine. Fully vaccinated, for new *** employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE. MINAKSHI SANGWAN Recruiting Lead - US Recruitment O ************ E *************************** W **********************

Junior Bioinformatics Student Researcher (Single-Cell Biology) We are seeking a motivated student with emerging interest in computational biology to join our research group and contribute to single-cell transcriptomics projects. This position is ideal for a student eager to build experience in modern genomics, coding for biological analysis, and collaborative research in a wet-lab + computational environment. Role Overview The Junior Bioinformatics Researcher will assist with processing and analyzing single-cell and spatial transcriptomics data, support ongoing projects, and learn standard analysis workflows under mentorship from lab members. Key Responsibilities · Assist with data parsing, preprocessing and QC of single-cell RNA-seq and spatial transcriptomics datasets · Apply analysis tools such as Seurat, Scanpy, and basic Linux command-line workflows · Support integration, clustering, differential expression, and cell-type annotation · Help maintain organized scripts, notebooks, and data files · Generate visualizations and figures for meetings and data reviews · Participate in lab discussions, contribute ideas, and develop independent skills over time Training & Skills Development The student will gain experience in: · R/Python coding for biological data analysis · Single-cell pipelines (10x Genomics, Cell Ranger, Seurat/Scanpy) · Data visualization and reproducible workflows · Basic HPC/terminal use, Git version control, and documentation practices · Biological interpretation of transcriptomic results Preferred Qualifications · Undergraduate or early grad student in Biology, Bioinformatics, Computer Science, Engineering, Neuroscience, or related field · Interest in learning single-cell genomics and computational analysis · Intermediate experience coding in R or Python (coursework or self-taught accepted) · Curiosity, organization, and willingness to learn new computational tools Nice-to-Have · Previous coursework in genetics, molecular biology, or data science · Familiarity with Jupyter/RStudio environments

Job Description & Requirements Internal Medicine Outpatient / Boston Metro Area StartDate: ASAP Pay Rate: $285000.00 - $310000.00 Brigham and Women's Harbor Medical Associates seeks an Internal Medicine Physician to join an established practice in Boston's South Shore community.

We save lives while providing the opportunity for people to realize their healthy selves. Family Medicine/Internal Medicine Physician Walden Behavioral Care Dedham, MA Walden Behavioral Care, a Monte Nido & Affiliates company, is a leading provider of specialized eating disorder treatment, offering inpatient, residential, and outpatient programs. We are committed to delivering compassionate, evidence-based care that empowers individuals on their path to recovery.

About Stoke: Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights STK-002 is Stoke's proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals. Stoke's initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach. Position Purpose: We are seeking a dedicated and highly motivated Principal Scientist in Oligonucleotide chemistry to join a dynamic team focused on advancing oligonucleotide-based therapeutics. Within the chemistry team, you will work with talented scientists in managing the synthesis of bioactive oligonucleotides for our drug discovery programs and delivering to the project teams with strict timelines. Successful candidates will have significant experience with solid phase chemical synthesis of oligonucleotide, conjugation, HPLC purification, and LC-MS analysis. This position will report to the Director, Chemistry. Key Responsibilities: * Independently design and implement scientific and synthesis strategies relating to the research and development of antisense and other synthetic oligonucleotide therapeutics. * Contribute to multiple projects and provide key technical knowledge to the project team. * Plan and execute solid-phase oligonucleotide synthesis for SAR campaigns on several projects. * Participate in the identification, development, validation and implementation of both current and next-generation technologies to enable proprietary ASO therapeutic development including purchase and installation of hardware and software supporting synthesis, purification, and characterization of oligonucleotides. * Demonstrate working knowledge of conjugation chemistry and techniques aimed at producing novel conjugates. * Demonstrates understanding of the chemistry of nucleosides, nucleotides, and oligonucleotides as applied to antisense and other oligonucleotide technologies. * Stay current with scientific literature and understanding of the state of the art in oligonucleotide chemistry, purification, and screening strategies. * Work with both internal chemistry team and external CRO's to generate innovative solutions to synthetic and drug design challenges within the context of oligonucleotide drug discovery projects. * Authors reports and manuscripts. May contribute to patent filings and/or regulatory filing. Required Skills & Experience: * PhD in Oligonucleotide Chemistry and relevant experience in a drug discovery environment with at least 8 years of oligonucleotide synthesis experience in a drug discovery environment, Master's degree with 12+ years of experience or Bachelor's degree with 18+ years of experience. * Strong practical knowledge of design, synthesis, and purification of synthetic oligonucleotides. * Experience in scale-up synthesis would be a plus. * Excellent project/time management, and problem-solving skills. * Excellent written and verbal communication skills, including making effective and compelling presentations in both large and small groups and communicating complex scientific and nonscientific issues to program teams. * Strong people skills and the ability to thrive in a team and goal driven environment * Experience designing, synthesizing and purifying oligonucleotides to support research and scale up studies. * Proven track record of scientific contributions in oligonucleotide and conjugates research as evidenced by publications/presentations/patent applications and/or the identification of preclinical development candidates. Location(s): Stoke operates in Bedford, MA. This is a lab-based position based in our Bedford, MA location. Travel: This position will require approximately 0% travel. Compensation & Benefits: At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $169,000 - $191,000 The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation. Our benefits package includes medical, dental and vision insurance; life, long and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP). Culture & Values: At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center: ****************************************** For more information, visit *********************************** All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status. Stoke participates in E-Verify.

About Stoke: Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights STK-002 is Stoke's proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals. Stoke's initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach. Position Purpose: The Vice President, Commercial Manufacturing - Rare Diseases is responsible for the strategic and operational leadership of all commercial manufacturing activities supporting the company's rare disease portfolio. This executive will ensure reliable, compliant, and cost-effective production of highly specialized oligonucleotide therapies. The VP will lead external manufacturing networks to ensure product availability for patients with critical unmet medical need. This position will report into the SVP, Chemistry and Manufacturing. Key Responsibilities: Strategic & Operational Leadership * Develop and execute a comprehensive commercial manufacturing strategy aligned with the company's mission to deliver therapies for rare and ultra-rare diseases, maintaining appropriate levels of inventory to meet/exceed demand. * Oversee technology transfer from late-stage development into commercial GMP production, ensuring scalability and robustness for niche patient populations. * Interface with internal SMEs to support manufacturing operations and potential investigations or troubleshooting of ongoing manufacturing activities. Quality, Compliance & Regulatory * Ensure all manufacturing activities meet or exceed global regulatory standards (FDA, EMA, PMDA, MHRA, etc.). * Partner with Quality and Regulatory Affairs to maintain GMP compliance, validation, and audit readiness. * Embed a culture of safety, quality, and continuous improvement throughout all operations. Supply & Lifecycle Management * Direct supply planning and capacity management to ensure uninterrupted global supply for commercial and compassionate-use programs. * Support product lifecycle management, including post-approval process optimization and change control. * Manage risk mitigation and business continuity strategies for specialized therapies and limited-source materials. Financial & Business Leadership * Develop and manage operating budgets, capital investment plans, and cost optimization programs without compromising quality or compliance. * Support strategic business decisions, as well as corporate partnerships. Required Skills & Experience: * Advanced degree in Engineering, Biochemistry, Chemistry, Pharmaceutical Sciences, or related field; MBA and/or PhD preferred. * 15+ years of experience in pharmaceutical or biopharmaceutical manufacturing, with at least 8 years in senior operational leadership roles. * Recent NDA experience, including authorship of module 3 for submission. * Recent commercialization experience. * Demonstrated experience with rare disease products (oligonucleotide modalities would be a plus). * Deep understanding of GMP regulations and quality systems supporting GMP commercial manufacturing * Strong leadership, strategic planning, and cross-functional collaboration skills. * Exceptional communication and executive presence, with a track record of influencing internal and external stakeholders. Location(s): Stoke is located in Bedford, MA. This position is a hybrid position with an office based in Bedford, MA location. Travel: This position will require approximately 30% travel. Compensation & Benefits: At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $320,000 - $355,000 The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation. Our benefits package includes medical, dental and vision insurance; life, long and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP). Culture & Values: At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center: ****************************************** For more information, visit *********************************** All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status. Stoke participates in E-Verify.

Doctor of Medicine | Family Practice Location: Massachusetts, MA Employer: Healthcare Connections Pay: Competitive weekly pay (inquire for details) Shift Information: Days - 5 days Start Date: ASAP About the Position Coastal Massachusetts Medical Directorship: Family or Internal Medicine Are you a natural leader who is passionate about providing top-notch quality care to a diverse patient demographic regardless of their ability to pay? Our mission is just that and we are excited to be expanding

About Stoke: Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights STK-002 is Stoke's proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals. Stoke's initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach. Position Purpose: The Director, Patient Advocacy & Engagement will build upon and execute strategic advocacy engagement initiatives for Stoke's Dravet syndrome, ADOA, and Syngap1 programs, ensuring alignment across key Stoke functions throughout the product lifecycle. There will be a special focus on launch readiness in the U.S. for zorevunersen (Dravet syndrome) and capacity building in ADOA and Syngap1. Reporting to the Vice President of Patient Advocacy and Policy, the candidate must have strong experience in biotechnology or pharmaceutical advocacy with a broad understanding of the business. This person must thrive in a fast-paced environment, be motivated by the patient need and operate with utmost integrity. The Director will work collaboratively with cross functional team members to increase awareness of our programs in the patient community, and bring the patient voice into the everyday decision-making, programming and employee experience. Key Responsibilities: * Serve as a liaison between the company and patient community by maintaining strong, trusted relationships, proactively requesting and sharing insights, and responding to community questions and needs in a timely fashion * Ensure a strong connection between employees and the patient community, including identifying innovative and compliant ways for employees to connect with patients, families and disease communities * Collaborate internally and play a contributing role on cross-functional teams to create and deliver patient-facing programs and materials (i.e. clinical trial awareness, launch preparedness) * Ensure timely and accurate communication of company information and updates to the appropriate patient communities * Partner effectively with Product & Corporate Communications, Medical Affairs and Clinical Operations to ensure timely, consistent and compliant communication and responses to external patient inquiries about our programs, including clinical trials and access * Coordinate with Medical Affairs and other internal functions to review and approve patient organization funding and collaboration requests; actively contribute to policy and process design/improvements for these and other related activities * Lead initiatives to ensure patient insights are brought into Stoke decision-making such as advisory boards and ongoing input into programming and messaging * In collaboration with Medical Affairs, organize Stoke's strategic engagement with patient advocacy organizations at congresses and events * Support broader Corporate Affairs efforts, including employee engagement and corporate communications * Develop and deliver on an annual plan aligned to corporate and department goals, including developing and tracking KPIs and metrics to measure the success of advocacy initiatives; continually innovate and elevate Stoke's approach to patient advocacy and engagement by continuously learning and staying current with best practices * Manage the patient advocacy budget and lead and oversee external partners, consultants and agency resources. Required Skills & Experience: * Bachelor's degree, preferably in social science, science, public policy, or a health-related field * 10 years of professional experience in patient advocacy in a publicly traded biotech/pharmaceutical company or health-related non-profit. The ideal candidate has experience in rare disease, regulatory milestones (i.e., FDA Advisory Committee meetings and approvals), KOL and Society engagement, and commercial-stage experience * A thorough understanding of the pharmaceutical product lifecycle, including the pre-clinical, clinical, regulatory processes and commercial stages * Established track record of building and maintaining strong, trusted relationships with colleagues as well as with non-profit and/or patient communities * Demonstrated ability to create and lead successful patient advocate programs and partnerships in collaboration with internal teams and stakeholders * Excellent communication skills: written, verbal and presentation delivery; A good listener * Strategic thinker and problem solver; intellectually curious and perceptive; able to identify interdependencies and connections across the business; a critical thinker * Comfortable in a fast-moving, rapidly changing environment; able to establish structure and process when needed; consistently prioritizes high-impact projects; calm under pressure; works with a sense of purpose and urgency * Understanding of laws and regulations governing the biopharmaceutical industry with an understanding of regulatory bodies that impact communications and reimbursement, understanding of publicly-traded company communications requirements and rules * Proven understanding of the needs of individuals living with severe and rare diseases and a demonstrated passion for supporting the patient community * Holds self and others to a high standard of ethics and integrity. Maintains confidentiality, exercises good judgment and discretion * Strong leadership skills with demonstrated ability to influence and collaborate across the organization and at all levels, both internally and externally * Able to work independently with minimal supervision * Experience working with all levels of management and consulting with key business stakeholders with an ability to influence for greater outcomes * Ability to travel to key U.S. and global congresses and patient events, as needed (up to 30%) Location(s): Stoke is located in Bedford, MA. This position is a hybrid position (2-3 days/week) with an office setting based in Bedford, MA location. Travel: This position will require approximately 30% travel. Compensation & Benefits: At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $231,000 - $242,000 The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation. Our benefits package includes medical, dental and vision insurance; life, long and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP). Culture & Values: At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center: ****************************************** For more information, visit *********************************** All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status. Stoke participates in E-Verify.

Job Description & Requirements Director of Anesthesiology Opportunity in New England StartDate: ASAP Pay Rate: $650.00 - $700000.00 An esteemed, award-winning organization located in a picturesque New England community is actively seeking a qualified Director of Anesthesiology to join its dynamic team. This is an exceptional opportunity to experience a fulfilling work-life balance in a region known for its natural beauty and vibrant community.

About Stoke: Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights STK-002 is Stoke's proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals. Stoke's initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach. Position Purpose: The Senior Manager of Scientific Communications Operations will be responsible for the operational aspects of the Medical Affairs team. The lead will work with members of medical affairs and cross functional partners to ensure excellence in operational processes and tactical execution that supports the goals of the company. This position will report to the Director of Scientific Communications Operations. Key Responsibilities: * Manage Medical Information systems and tools, including drafting responses, vendor management, triaging, etc. * Provide project management support for key Medical Affairs initiatives, including medical congress planning, by ensuring timely and effective execution. * Follow established congress framework to coordinate and execute cross-functional congress planning meetings to align objectives and activities. * Support end-to-end congress operations, including medical booth planning, KOL engagement coordination, activity tracking, and onsite logistics, ensuring alignment with strategic objectives and seamless execution. * Track, analyze, and report on congress performance metrics to generate actionable insights that support future congress planning and strategic decision-making. * Leverage post-congress insights and performance data to identify engagement trends, uncover opportunities for improvement, and enable scalable growth of Medical Affairs. * Support the MLR review process for congress-related and other medical materials, including managing submissions, referencing, version control, and coordination with internal teams and external partners. * Drive continuous improvement across all Medical Affairs by identifying opportunities to enhance operational efficiency, promote cross-functional collaboration, and optimize the execution of key initiatives. * Support the development, implementation, and maintenance of SOPs for core Medical Affairs functions, including congress planning, medical education, publications, and related areas. * Any and all other operational responsibilities as requested Required Skills & Experience: * Bachelor's degree required * Strong operational knowledge of medical affairs or other similar departments * 6+ years of related experience in medical affairs, clinical operations, or project management within the pharmaceutical or biotechnology industry * Innovative, solution-oriented thinker * Ability to work collaboratively in a highly matrixed organization * Excellent verbal and written communication skills * Strong problem-solving skills and the ability to adapt to changing priorities and deadlines * Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects Location(s): Stoke is located in Bedford, MA. This position is a hybrid position with an office setting based in Bedford, MA location. Travel: This position will require approximately 10% travel. Compensation & Benefits: At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is $175,000 - $202,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation. Our benefits package includes medical, dental and vision insurance; life, long and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP). Culture & Values: At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center: ****************************************** For more information, visit *********************************** All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status. Stoke participates in E-Verify.

The Opportunity: Does delivering a great small molecule development candidate thrill you? We get excited, too, and we are building the best environment in the industry to discover the next generation of innovative therapeutics that will make a difference for patients. We are looking for a self-motivated, experienced Medicinal Chemist to join our team. You will work on exciting targets alongside some of the most talented scientists in a highly collaborative environment, while continuing to grow into better drug hunter. Your Role: You will be responsible for developing and executing medicinal chemistry strategies on a lead optimization program to deliver a high-quality development candidate in a fast-paced environment. You will lead chemists at Relay as well as CRO teams to advance your project. You will work closely and collaboratively in a multi-disciplinary team of computational chemists, biophysicists, cell and molecular biologists, pharmacologists, and DMPK specialists. You will see how all the aspects of compound performance are necessary to make it a drug, and you can communicate that effectively to your discovery partners. Your background: PhD with at least 5 years or MS with at least 8 years of relevant biotech and/or pharmaceutical industry experience in medicinal chemistry, with an emphasis on lead optimization in small molecule drug discovery You were educated in chemistry with an emphasis on synthetic organic chemistry, synthetic methodology or a related field. You are passionate about working on high impact targets and bringing medicines to patients. You have led or are ready to lead a team and make critical decisions on the SAR direction. You have participated in the delivery of development candidates and your track record of excellence is supported by high impact, peer-reviewed publications and/or patents. You have good understanding of biology, pharmacology, DMPK and safety. You are comfortable enabling your compound design with in silico predictive tools and structure-based drug design. You have strong communication skills, can flex to different work styles, and believe that the best outcomes result from bringing out the creativity of your colleagues. You are committed to building an energetic, collaborative and open company culture and contributing to the company's success. #BP1 About Relay Therapeutics Relay Therapeutics is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process. Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. If you're excited by the challenge of putting protein motion at the heart of drug discovery and passionate about making a difference in the lives of patients, join us!

The Opportunity: As the Senior Associate / Manager, CMC Operations, you will play a key role in supporting CMC financial and operational activities across Relay Tx's development programs. In this highly cross-functional role, you will partner closely with internal technical leads and external manufacturing partners to ensure the timely, compliant, and efficient delivery of clinical materials and associated documentation by providing all necessary support to the Pharmaceutical Development Team. The ideal candidate brings strong project management and operational execution skills, have some experience in a clinical-stage biotech environment, and the ability to navigate complex, cross-functional deliverables. This position reports to the Sr. Director, CMC Operations. Your Role: Financial Support & Budget Management Collaborate with CMC, Accounting, and Finance teams to support the creation and maintenance of department budgets and forecasts. Generate and finalize all departmental Purchase Orders (POs) within the Coupa system; track progress to ensure timely approval. Confirm that all PO requests are accurately captured in the budget; escalate and obtain approval for any items not previously included. Ensure contracts contain appropriate legal language, milestones, and payment terms. Track CMC operational expenses against budget by conducting monthly reviews of accruals in partnership with CMC functional leads (Drug Substance, Drug Product, Analytical Development, Quality, and Clinical Supply) and Finance. Vendor and Contract Management Support the onboarding of new CMC and supply chain vendors. Meet with vendors monthly (or as needed) to monitor spending against approved contracts. Coordinate internal and external vendor communications and action items, including contract and PO management, budget and accrual oversight, material transfers, and inventory system support. Operational & Program Support Support the execution of CMC activities across Drug Substance, Drug Product, Analytical Development/Manufacturing, and Clinical Supply Chain, including scheduling and project management tasks. Assist in the development and alignment of CMC project plans, risk assessments, and timelines with overall program goals; ensure timely communication of project status, timeline changes, cost updates, and risks to team members and functional leaders. Facilitate internal CMC team meetings, track action items, and maintain documentation to drive operational excellence. Contribute to continuous improvement efforts across CMC processes, tools, and data management systems. Your Background: Education Bachelor's degree in life sciences, engineering, business, or a related field required. Experience 3 to 5 years of experience in CMC operations, technical operations, or pharmaceutical manufacturing within a biotech or pharmaceutical company. Experience supporting clinical-stage programs and working with CDMOs. Working knowledge of GMP, ICH guidelines, and regulatory expectations for CMC development. Skills & Attributes Strong project management, organizational, and communication skills. Detail-oriented and proactive, with the ability to anticipate and resolve issues. Collaborative mindset with the ability to work effectively within cross-functional teams. Comfortable operating in a dynamic environment with evolving priorities. Estimated Salary Range: [$87,000 - $145,000]. The range provided above is based on what we believe to be a reasonable estimate for this job at the time of posting. Actual base salary will depend on a number of factors, including but not limited to, a candidate's education, experience, skills and location. #JO1 About Relay Therapeutics Relay Therapeutics is a clinical-stage precision medicines company transforming the drug discovery process with the goal of bringing life-changing therapies to patients. Built on unparalleled insights into protein motion and how this dynamic behavior relates to protein function, we aim to effectively drug protein targets that have previously been intractable, with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of leading-edge experimental and computational approaches to provide a differentiated understanding of protein structure and motion to drug these targets. We have built a world-class team of leading experts from each of these disciplines, and they are driven by a deep collaboration at every step of our drug discovery process. Our team is equal parts fearless and relentless, with a shared passion for working collaboratively in intellectually stimulating environments. If you're excited by the challenge of putting protein motion at the heart of drug discovery and passionate about making a difference in the lives of patients, join us!

Job Type: Full-time Schedule: Flexible shifts | No nights | No on-call | Rotating weekends/holidays Sign-On Bonus: $20,000 Elevate Your Career with AFC Urgent Care ? Where Quality Meets Purpose At American Family Care (AFC), we deliver high-quality, accessible healthcare ? and we?re growing fast. Join a nationally recognized leader in urgent care where your clinical talent meets a team that genuinely supports your success and growth. Whether you?re looking to sharpen your clinical skills or simply work in a place where your contributions are valued, AFC Worcester offers the opportunity, autonomy, and flexibility you need to thrive. Why You?ll Love Working with Us: $20,000 Sign-On Bonus 100% Outpatient ? No Nights, No Call Competitive Base Pay + Performance Bonuses Flexible Shift-Based Schedule (includes rotating weekends/holidays) Collaborative Clinical Team and supportive leadership Ongoing Professional Development & CME Support What You?ll Do: Diagnose and manage a wide range of acute conditions in patients of all ages Provide treatment for injuries, infections, and urgent care needs Perform minor procedures: suturing, splinting, incision & drainage, etc. Conduct physical exams, including DOT and pre-employment physicals Order and interpret labs, X-rays, and EKGs Counsel patients on treatment plans and preventive care Maintain timely, accurate clinical documentation Collaborate with supervising physicians and clinical team members Who We?re Looking For: Certified Nurse Practitioner (ANCC/AANP) or Physician Assistant (NCCPA) 2+ years of experience in urgent care, primary care, or emergency medicine Proficient in urgent care procedures and confident in fast-paced settings Strong communicator with a passion for patient education and community care Benefits & Perks: We support our providers with benefits that prioritize your well-being: Medical, Dental & Vision Insurance 401(k) with Employer Match Generous PTO Malpractice Insurance (100% covered) Life, Short- & Long-Term Disability Insurance UpToDate Subscription CME Allowance & Education Resources About AFC Urgent Care With 200+ clinics in 26 states, AFC is the largest urgent care network in the U.S. We?re known for modern, efficient care settings equipped with on-site labs, digital X-ray, and cutting-edge technology ? all designed to support excellent clinical care and a great provider experience. Make Your Next Career Move Count If you?re looking for clinical variety, schedule flexibility, and a team that values your work, AFC Springfield is ready to welcome you. Apply today. Grow with AFC. Make a meaningful impact. #JoinTheAFCAPPTeam AFC is an Equal Opportunity Employer and makes all employment decisions without regard to race, color, religion, sex, sexual orientation, gender identity or expression, age, national origin, disability, veteran status, genetic information, or any other status protected by applicable law. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills, and we believe that diversity drives innovation and excellence in patient care. AFC is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment. To request accommodation during the application or interview process, please contact us at *********************************. At AFC, we are committed to fair and transparent compensation practices. The anticipated pay range for this position is $90.00 per hour. Actual compensation may vary based on a variety of factors, including but not limited to relevant experience, skills, education, certifications, internal equity, and market conditions. We take a holistic approach to compensation that reflects the value each team member brings to our organization. Contact Donna Lovallo, AFC Urgent Care, Sr. Director of Operations, ******************************* Job Types: Full-time, Part-time Pay: $85.00 - $90.00 per hour Benefits: 401(k) Dental insurance Flexible schedule Health insurance Paid time off Vision insurance Medical Specialty: Urgent Care Schedule: 10 hour shift 12 hour shift 8 hour shift Work Location: In person

About Stoke: Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights STK-002 is Stoke's proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals. Stoke's initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach. Position Purpose: The Director/Senior Director, Medical Affairs - RMD (South) will be a core member of the global medical affairs team and will help establish core medical capabilities at Stoke Therapeutics. This is a field-based role and will primarily be responsible for representing Stoke Therapeutics with a network of external clinical experts or key opinion leaders (KOLs) in a regional area, while advancing prioritized Medical Affairs activities in collaboration with cross-functional teams. The role will initially be an individual contributor role, actively engaging a defined group of Stoke clinical investigators and key opinion leaders (KOLs) in developmental and epileptic encephalopathies (DEEs) and leading or supporting clinical discussions with national and regional payers in the US primarily, while also supporting international investigator and KOL engagement as needed. Key Responsibilities: * Work closely with clinical operations and development teams to support Stoke clinical study efforts, including site identification and engagement to advance enrollment while fostering collaborative research relationships with academic and community KOLs. * Establish and maintain highly credible, scientific relationships with academic and medical thought leaders. * Serve as field medical point of scientific/clinical contact or support for national and regional payers, healthcare systems, integrated delivery networks and other managed care organizations * Work closely with internal team members to facilitate and support congress strategy at scientific meetings, including KOL engagement planning, insight gathering on key topics, and interpretative reports to share with cross functional teams. * Develop, share, and discuss ongoing clinical insights with cross-functional members to ensure awareness and understanding of KOL perspectives to inform and guide strategic decision-making. * Develop strategic profiles for top experts and clinical staff at centers of comprehensive care, to help identify key opportunities for ongoing education and collaboration. * Develop key performance and reputation measures to ensure ongoing alignment of Stoke activities to KOL and HCP expectations and needs. * Collaborate closely with other functions including clinical, commercial and PR/IR/Advocacy to engage and support external stakeholder needs through activities such as scientific education, advisory boards, investigator meetings, publications, congresses, and other activities of interest. * Must be able to perform duties typically associated with a normal office environment when not traveling. * All other duties as assigned. Required Skills & Experience: * Advanced scientific or clinical degree, with at least 10+ years in relevant clinical/scientific fields and 5+ years of Medical Affairs experience, with significant focus on field medical activities. * Experience with prelaunch and rare diseases in epilepsy, neurology highly preferred. * Prior track record of success and proficiency in role working directly with clinical and academic experts is required. * Knowledge of and engagement experience with national and regional payers is a plus * Excellent verbal and written communication skills, and exceptional interpersonal skills. * Demonstrated skills in leading and mentoring others. * Good judgment, ability to adapt and change in a shifting environment. * A strategic, passionate, self-starter who takes initiative. * Ability to work independently and function effectively as a team member. * Excellent problem-solving skills. * Valid driver's license and the ability to travel as necessary. Location(s): Stoke is located in Bedford, MA. This position is remote, field- based in the continental United States, and is responsible for a regionally designated area Travel: This position will require approximately 60%+ travel, including the ability to travel overnight, internationally, and occasionally on weekends. Compensation & Benefits: At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program. The anticipated salary range for this role is Director level is $236,000 - $266,000 and at the Sr. Director level is $294,000 - $329,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation. Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP). Culture & Values: At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation. Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do. Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center: ****************************************** For more information, visit *********************************** All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status. Stoke participates in E-Verify.