Research Scientist IV
Research scientist job in Spring House, PA
Source One is a consulting services company and we're currently looking for the following individual to work as a consultant with our direct client, a global Pharmaceutical Manufacturing client in Spring House, PA.
No Third-Party, No Corp to Corp, No Sponsorship. Must be able to work in the US and must not require sponsorship for employment visa status now or in the future (e.g., FI, H1-B status)
Title: Research Scientist IV
Location: Spring House, PA
Onsite (Mon-Fri, 40 hours)
Contract Duration: 12 months, with likely extension
Pay Rate: $67.88 per hour (w2)
Key Responsibilities:
• Support membrane protein expression and purification.
• Conduct protein production, purification and characterization.
• Characterization and quality check of membrane proteins to support biotherapeutics development.
• Collaborate effectively in a multi-team environment.
• Contribute to both internal and external efforts in membrane protein production.
Education:
• Minimum of BS Degree with a minimum of 2-4 years of academic/industry experience or MS Degree with a minimum of 1-2 years is required.
Required Skills:
• Experience with membrane protein expression and optimization, purification, and characterization of proteins
• Well-versed with analytical characterization to determine quality, conformation, purity and stability
• Knowledge of protein expression construct design and optimization, and expression platforms
• Excellent communication skills to collaborate with internal and external partners
Preferred:
• Proficient in protein purification optimization, detergent screening, and reconstitutions into lipid nanodiscs
• Experience in independently operating AKTA FPLC and analytical HPLC instruments
• Experience in generating DNA/RNA constructs and or other tools as antigen for supporting antibody discovery
• Knowledge and experience with CROs for protein production
Scientist 4 - Research and Development
Research scientist job in Spring House, PA
Immediate need for a talented Scientist 4 - Research and Development. This is a 12+ Months Contract opportunity with long-term potential and is located in Spring House, PA (Onsite). Please review the job description below and contact me ASAP if you are interested.
Job ID:25-94738
Pay Range: $57 - $67/hour. Employee benefits include, but are not limited to, health insurance (medical, dental, vision), 401(k) plan, and paid sick leave (depending on work location).
Key Responsibilities:
Support membrane protein expression and purification.
Conduct protein production, purification and characterization.
Characterization and quality check of membrane proteins to support biotherapeutics development.
Collaborate effectively in a multi-team environment.
Contribute to both internal and external efforts in membrane protein production.
Key Requirements and Technology Experience:
Skills-Experience in independently operating AKTA FPLC and analytical HPLC instruments.
Proficient in protein purification optimization, detergent screening, and reconstitutions into lipid nanodiscs.
Minimum of BS Degree with a minimum of 2-4 years of academic/industry experience or MS Degree with a minimum of 1-2 years is required.
Experience with membrane protein expression and optimization, purification, and characterization of proteins
Well-versed with analytical characterization to determine quality, conformation, purity and stability
Knowledge of protein expression construct design and optimization, and expression platforms
Excellent communication skills to collaborate with internal and external partners
Proficient in protein purification optimization, detergent screening, and reconstitutions into lipid nanodiscs
Experience in independently operating AKTA FPLC and analytical HPLC instruments
Experience in generating DNA/RNA constructs and or other tools as antigen for supporting antibody discovery
Knowledge and experience with CROs for protein production
Our client is a leading Pharmaceutical Industry and we are currently interviewing to fill this and other similar contract positions. If you are interested in this position, please apply online for immediate consideration.
Pyramid Consulting, Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.
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Associate Scientist
Research scientist job in Lansdale, PA
Job Title: Scientist
Duration: 12 Months
Pay Rate: $32/hr on W2
Education:
• B.S. in Biology, Bio/chemistry, Bio/chemical Engineering, or related science or engineering field.
• At least 1yr of laboratory experience in Molecular Biology, Protein Biochemistry, and/or upstream process development.
The ideal candidate would possess:
• General laboratory skills, experience with aseptic manipulations, pipettes
• Experience in culturing microbial cells at different scales
• Experience in protein biochemistry and analytical methods (e.g. SDS-PAGE, Western Blot, ELISA)
• Basic knowledge of fermentation
• Experience using formulas and linking spreadsheets in Excel
• Highly computer literate. Capable of quickly learning and adapting to new computer programs. Strong computer, scientific, and organizational skills
• Excellent communication (oral and written) and attention to detail
• Ability to work independently and as part of a team, self-motivation, adaptability, and a positive attitude
• Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.
Additional Requirements:
• This position will require occasional off-hour and/or weekend work (10-20% of hours may be “off-shift”)
• This position will require work with Biosafety Level-1 organisms
Responsibilities:
Scientist responsibilities include, but are not limited to, the following:
• Prepare laboratory reagents, solutions, and culture media
• Perform lab-scale fermentation runs to meet different needs
• Set up process equipment for lab-scale experiments
• Perform analytical assays
• Analyze, collate, track, and report data back to client staff members
• Maintain records and test results following good laboratory practices (GLP) guidance
• Work independently and efficiently
• Document work clearly and perform tests accurately
• Communicate effectively with client staff members
Equipment Validation Scientist
Research scientist job in Lansdale, PA
Job Title: Equipment Validation Scientist
Hours: Monday-Friday, 9:00am-5:00pm
Hiring Method: 3 Year Contract
Pay Range: $40.00 - $45.00/hr
Benefits: Health, Dental, Vision Insurance + 10 Days PTO, 6 Sick Days, and all company paid holidays annually
Job Description
Our Bio-pharmaceutical Client is seeking an Equipment Validation Scientist to join their team in West Point, PA. This individual will be a part of the Discovery, Preclinical and Translational Medicine Operations organization and will be responsible for supporting process automation systems in clinical and non-clinical Regulated Bioanalytic, Vaccine Modernization laboratories. This position may provide direct support to lab equipment maintenance, system security, data management, obsolescence initiatives, and all SDLC and Compliance needs. They will work closely with divisional/enterprise Information teams, global infrastructure, and risk/security organizations to ensure that project deliverables and ongoing operations receive appropriate support. They will also be responsible for the successful implementation of Automation solutions, system and equipment validation, Change Control and testing documentation. The Equipment Validation Scientist will develop a suite of reporting, analytics and visualization solutions that support local clinical operations and administrative business processes; ensure automation systems are maintained in a validated state, as part of an active/ongoing lifecycle management program and in compliance with Current GXP requirements; And will be accountable for implementing system changes and conducting system investigations. They will have active and engaged participation in the routine operations support processes as well as supporting a culture of continuous improvement at the site. This will include trouble-shooting challenging equipment/automation issues to improve performance, engaging in vendor and IT support needs, responding to alarms, and implementing future AI/ML capabilities as available. They will be providing support or leading a small startup or existing production team providing technical assistance in fulfilling the automation requirements for the team and reviewing automation documents, preventive maintenance, and Standard Operating Procedures to ensure compliance with GXP Practice and corporate safety requirements. In addition, they will be developing and supporting corrective actions for investigations related to automation systems, using technical knowledge to assure the efficient operation of a variety of automated processing and operational and informational technology systems and participating in compliance audits and training programs including providing client services support for business area laboratory applications.
Required Skills and Experience
Laboratory Experience
Lab Equipment Maintenance experience
SDLC Experience
GLP or GXP experience
Bachelor's degree in Scientific or Engineering field
Nice to Have Skills and Experience
Master's Degree
Automation Experience
Compensation:
$40.00/hr to $45.00/hr.
Exact compensation may vary based on several factors, including skills, experience, and education.
Healthcare benefit packages for this role will start on the 1st day of employment and include medical, dental, and vision insurance, financial protection benefits, as well as HSA, FSA, and DCFSA account options. 401k retirement account access is offered starting on the 90th day with employer matching after one year of service. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.
Principal Protein scientist
Research scientist job in Spring House, PA
Duration: 12Months
Required Skills
Role is 100% onsite in Spring House, PA
Bachelor's degree is required
#1 Required skill: Must have processing protein production, purification experience
#2 Required skill: Must have analytical characterization experience
Membrane protein experience, a huge plus
Must have 2-4 years of experience
Will attend group meetings
60%-70% of the role will be lab based work
Will do data capturing
Description:
Key Responsibilities:
Support membrane protein expression and purification.
Conduct protein production, purification and characterization.
Characterization and quality check of membrane proteins to support biotherapeutics development.
Collaborate effectively in a multi-team environment.
Contribute to both internal and external efforts in membrane protein production.
Qualifications
Minimum of BS Degree with a minimum of 2-4 years of academic/industry experience or MS Degree with a minimum of 1-2 years is required.
Experience and Skills:
Experience with membrane protein expression and optimization, purification, and characterization of proteins
Well-versed with analytical characterization to determine quality, conformation, purity and stability
Knowledge of protein expression construct design and optimization, and expression platforms
Excellent communication skills to collaborate with internal and external partners
Preferred:
Proficient in protein purification optimization, detergent screening, and reconstitutions into lipid nanodiscs
Experience in independently operating AKTA FPLC and analytical HPLC instruments
Experience in generating DNA/RNA constructs and or other tools as antigen for supporting antibody discovery
Knowledge and experience with CROs for protein production
About US Tech Solutions:
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit ************************
US Tech Solutions is an Equal Opportunity Employer.All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Recruiter Details:
Name: I.Prudvi kumar
Email: *******************************
Internal Id: 25- 54564
Epidemiologist Research Associate
Research scientist job in Media, PA
The Epidemiologist Research Associate is responsible for all infectious disease surveillance, investigations and interventions utilizing state-of-the-art public health principles, and methodologies of the science of epidemiology. Work shall be performed under the professional and programmatic oversight of the Delaware County Health Department Administration using relevant national standards of excellence; designated epidemiology and analytical tools and standards; and Delaware County Health Department policies, procedures and regulations.
The position provides a 24/7/365 expert, consultative service for the scientific disciplines of epidemiology, medicine, public health and disease prevention and control within the County. The position may supervise professional, technical and clerical subordinates. Incumbents shall conduct assessments of public health hazards; carry out epidemiological investigations; communicate/consult with regional and local health officials; and attend professional meetings throughout the United States as guided by Delaware County Health Department Administration. The Epidemiology Research Associate reports to the Delaware County Health Department Epidemiologist.
Essential Duties
* Responsible for disease outbreak investigations, managing and analyzing population-based data to identify risk factors and health needs, and analyzing service-based data to provide program evaluations
* Routinely analyze births, deaths, and disease data, and provide epidemiological interpretation
* Conduct disease cluster analysis by examining population-based data, preparing statistics, providing epidemiological interpretation of statistics, and writing reports
* Lead design, planning, analysis, and reporting of information and health intelligence based on large population-based data sets
* Assist in the evaluation of interventions or programs' effectiveness
* Research public health issues and prepare health reports and issue briefs
* Assist other staff members gain knowledge of basic epidemiology tools and techniques
* Participate in coordinated response activities during public health emergencies through the department's emergency management and incident command system
* Provide technical assistance for users of surveillance systems and/or other databases
* Member of health needs assessment Core Committee
* Work shall be performed under the professional and programmatic oversight of the Delaware County Health Department, Epidemiology Division
* The ERA provides expert consultative service for the scientific disciplines of epidemiology, medicine, public health and disease prevention and control within the County
* The position may supervise professional, technical, and clerical subordinates
* Incumbents shall conduct assessments of public health hazards; carry out epidemiological investigations; communicate/consult with regional and local health officials; and attend professional meetings
* Perform other duties, tasks and special projects, as required.
Qualifications
* Master's degree in public health with concentration in epidemiology and/or biostatistics
* 3-5 years of field experience in detecting, controlling, or reporting illness and diseases preferred
* Skills in data analysis based on large data sets, questionnaires, and interviews
* Strong skills in oral and written communication, which includes preparation of reports, training education to public health partners and the general public, preparing written manuscripts for peer-reviewed journals and other publications
* Expertise with statistical software SAS, STATA, SPSS, Epi-Info, etc.
* Familiarity with complex surveys and statistical analysis, e.g., CDC NHANES
* Demonstrated experience effectively leading and directing staff and/or volunteers
* Valid driver's license and ability to pass a background check
* Ability to interact appropriately and effectively with a wide range of persons
* Ability to maintain and handle confidential information
* Ability to follow protocol, procedures, and established guidelines
* Ability to be flexible and adapt to changing circumstances and needs
* A strong work ethic and ability to manage a demanding and changing workload
* Strong relationship-building skills
Preferred Skills, Knowledge & Experience
* Strong critical thinking and problem-solving abilities to identify, analyze, and address complex epidemiological issues.
* Commitment to maintaining high ethical standards in research, including adherence to ethical guidelines and regulations governing human subjects research.
* Ability to adapt to changing research environments and methodologies, and to
Biology - Imaging R&D
Research scientist job in Philadelphia, PA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Position Overview:Eli Lilly and Company (Lilly) Imaging Research and Development provides technical expertise for molecular and anatomical imaging to Lilly Research Laboratories. The Biologist will provide histopathology support by assisting in human tissue labeling to establish well-characterized tissue panels for compound screening and pathophysiological evaluation of target expression towards the discovery of new PET tracers for evaluation as development candidates.Responsibilities:• Design, develop, and execute human brain tissue characterization protocols (sample preparation and cryosectioning, staining, immunohistochemistry and autoradiography) for neuroscience research and imaging biomarker projects.• Assist in organization of tissue staining data from various research projects• Conduct and design radioligand binding assays such as autoradiography.• Implement digital pathology tools compatible with whole slide imaging scanner, autoradiography and confocal microscopy.Basic Qualifications:• Master of science degree, preferentially in Neuroscience with a minimum of 1 year experience in PET tracer discovery.Additional Skills/Preferences:Proficiency in immunohistochemistry, including immunofluorescence, automated histology equipment, spatial omics platform, gene silencing knowledge, and morphometry image analysis software (Visiopharm).• Provide strategic and technical expertise on the design and optimization of protein and transcript target detection.• Develop morphometric quantitative analysis methods using AI/ML software for target mapping in human samples• Experience in rodent and human tissue preparation and handling• Evaluation of small molecules and biologicals• Ensure good laboratory practice for data documentation as well as communicate research findings and recommendations to internal and external stakeholders through written reports, oral presentations and scientific communications.• In-depth knowledge of rodent and human neuroanatomy• Understanding of neuropathological hallmarks scoring• Use of real-time autoradiography is preferred• Ability to be pro-active, flexible, and capable of independent trouble shooting and problem solving. Work within a team-oriented lab environment and work within cross-functional project teams• Participate in scientific conferences and workshops to continue education/professional development• Good organizational and time-management skills• Excellent written and verbal communication skills
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (******************************************************** for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$65,250 - $169,400
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
Auto-ApplyResearch Associate
Research scientist job in Spring House, PA
Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost.
Job Description
As a member of Janssen Developability Group, you will be working with a team responsible for developability assessments and pre-clinical formulation development, aiding the identification of small molecule clinical candidates. You will be responsible for generating data under the guidance and supervision of a senior scientist, while maintaining accurate and well-organized laboratory records, worksheets and notebooks. Ideal candidate will be able to multi-task while working in a fast-paced and team-oriented environment.
Technical qualifications:
1. Hands-on expertise with analytical techniques used for the solution characterization of small molecules, such as chromatography (HPLC and uPLC, ideally with Empower data acquisition software) is a must have.
2. Experience with solid-state characterization of small molecules such as, thermal analysis, X-ray diffraction, particle size measurements and light microscopy is highly desired.
3. Good understanding of biopharmaceutical principles and hands-on expertise with pre-clinical formulation development and preparation is desired.
4. Experience in the design of pre-formulation, forced degradation studies, and peptide formulations is preferred.
Qualifications
1. BS in Chemistry, Pharmaceutical Sciences, chemistry or other closely related field preferred with 3+ years of experience in Biotech or Pharmaceutical industry.
2. Candidates with equivalent educational and professional backgrounds will also be considered.
Additional Information
Best Regards,
Anuj Mehta
************
Trainee - Postbaccalaureate Research Request
Research scientist job in Philadelphia, PA
The Monell Chemical Senses Center provides post-baccalaureate students with opportunities for hands-on lab research and other professional activities.
Enrollment in any post-baccalaureate program
Ability to commute to Monell (3500 Market Street, Philadelphia, 19104)
Scientist- Biologics
Research scientist job in Exton, PA
Scientist, Biologics Full-time Frontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.
Responsibilities:
Primary responsibilities include, but are not limited to the following:
* Perform analytical and biological sample testing
* Conduct method development and validation studies
* Perform immunoassay techniques: (ligand binding assays, ELISA, MSD, and/or RIA applicable to Pharmacokinetic and Immunogenicity studies), with proficiency
* Prepare and handle various cell lines, tissue culture media and other reagents for cell-based assays such as Neutralizing Antibody (NAb) assays
* Maintenance of instruments, and address technical and instrumental issues
* Assist the Principal Investigator with study conduct
* Maintain study documentation
* Meet regulatory compliance requirements
* Maintain a safe work environment
Requirements:
* Bachelor's degree in related scientific discipline or Bachelors degree with relevant experience
* At least 2 years working in a laboratory preferred
Salary and Benefits:
Frontage Laboratories offers a competitive compensation and benefits package including health and dental insurance, a 401(k) plan, disability insurance, and life insurance.
Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.
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Research Associate-I
Research scientist job in Spring House, PA
The candidate should have a BS/MS in biological sciences with research experience in cellular immunology and/or cell biology including significant hands-on experience performing cell culture and following proper aseptic technique. The successful candidate will be able to apply different research techniques in the work including immune cell isolation, immune cell culture, ELISA, MSD, and luminex assays. Experience with assays using purified immune cells, T-cell culture, and hybridoma generation would be ideal. The candidate should have a good understanding of immunology and/or cell biology, be able work independently, have strong quantitative skills, and be familiar with basic data analysis software and data interpretation. Good organizational skills, experimental documentation, and a proven ability to work collaboratively in a fast paced, highly matrixed, interactive environment is essential.
Additional Information
Senior Embryologist
Research scientist job in Chesterbrook, PA
Enjoy what you do while contributing to a company that makes a difference in people's lives. Shady Grove Fertility, one of the premier fertility centers in the United States, continually seeks experienced, compassionate, and dynamic team players who are committed to delivering exceptional patient care to join our growing practice. The work we do building families offers stimulation, challenge, and personal reward.
If you're an Embryologist looking for a new opportunity to work in a fast-paced, professional environment where your talent contributes to changing people's lives, then we want to talk to you. This position requires collaborating with physicians and other medical providers by providing expert care and service for fertility treatments.
Sign on Bonus of 10K! We currently have an opening for a full-time Embryologist to work in our fast paced, high volume, Embryology Lab located in our Chesterbrook, PA office. Working Monday - Friday 7:30 AM to 4:00 PM with rotating weekends, holiday rotation. Approximately 1 weekend/month
How You'll Contribute:
We always do whatever it takes, even if it isn't specifically our “job.” In general, the Embryologist is responsible for:
Identification, assessment and culture of oocytes; sperm preparation and insemination of oocytes (conventional insemination and ICSI)
Assessment and selection embryos for transfer; embryo vitrification, warming and storage
Oocyte vitrification, warming and storage
Preparation and care of gametes/embryos throughout the laboratory process: IVF, ICSI, VIT, ET, Warming and Embryo Biopsy
Vitrification and warming of embryos at varying stages of development
Assessing fertilization and zygote quality following insemination
Familiarity with data entry into an EMR
Familiarity with MESA, PESA, TESA and TESE collection
Experience with regulatory guidelines and inspections (e.g. CLIA, FDA, TJC, CAP)
What You'll Bring:
Minimum 5 years experience in Embryology.
Must have a Bachelor's degree or higher in a relevant laboratory science.
Must demonstrate the ability to function effectively without direct supervision, and to perform laboratory services in accordance with the Laboratory Philosophy and Operating Standards.
Proven ability to access, input, and retrieve information from a computer.
Knowledge of office procedures and office machines (i.e. computer, fax, copier, etc.).
Ability to work as part of a multidisciplinary team.
Ability to work in a high standard, stressful environment.
Ability to communicate accurately and concisely.
Ability to develop interpersonal working relationships with colleagues
Must be authorized to work in the U.S.A.
More important than the best skills, however, is the right person. Employees who embrace our mission, vision, and core values are highly successful.
What We Offer:
We are proud to provide a comprehensive and competitive benefits package tailored to support the needs of our team members across all employment types:
Full-Time Employees (30+ hours/week):
Medical, dental, and vision insurance, 401(k) with company match, tuition assistance, performance-based bonus opportunities, generous paid time off, and paid holidays
Part-Time Employees:
401(k) with company match and performance-based bonus opportunities
Per Diem Employees:
401(k) with company match
At Shady Grove Fertility, we promote and develop individual strengths in order to help staff grow personally and professionally. Our core values guide us daily to work hard and enjoy what we do. We're committed to growing our practice and are always looking to promote from within. This is an ideal time to join our team!
How To Get Started:
To have your resume reviewed by someone on our Talent Acquisition team, click on the “Apply” button. Or if you happen to know of someone who might be interested in this position, please feel free to share the job description by clicking on an option under “Share This Job” at the top of the screen.
Associate Scientist - Biologics Discovery
Research scientist job in Spring House, PA
Our large pharmaceutical clients is seeking an Associate Scientist to join their growing Biophysics & Molecular Attributes Group in Spring House, PA. The Biophysics & Molecular Attributes Group within Biologics Discovery uses innovative biophysical, biochemical, and mass spectrometry based analytical tools to help select best therapeutic candidates for clinical development. You will be a critical member of the Higher Order Structure (HOS) team that characterizes developability attributes like thermal stability, chemical stability, solubility, and aggregation on a broad range of biologics platforms including monoclonal antibodies, multi-specific antibodies, antibody drug conjugates, antibody radio conjugates, and other therapeutic proteins. You will design and perform experiments using a variety of technologies like HPLC, DSF, DSC, cIEF, GXII, DLS, and more.
Key Responsibilities:
Execute automated methods for biophysical and structural characterization of antibody therapeutics. Integrate robotic liquid handling systems (e.g., Hamilton, Tecan) with analytical platforms to improve efficiency, consistency, and sample throughput.
Execute analytical analysis of biologics candidates using a wide variety of technologies such as size-exclusion HPLC, plate-based HIC/Heparin binding, DSF.
Evaluate results to deliver scientifically supported conclusions and recommendations that are documented in appropriate technical reports.
Maintain lab and equipment.
Collaborate with colleagues in the global organization to support discovery projects.
Assist in developing recommendations for improving standard procedures.
Qualifications:
Master's or Bachelor's Degree in a related field of study
Minimum of 1 year of protein/antibody analytical methods experience
Experience using HPLC, DSF or DLS
Salary: $70,000-$75,000 (flexible based on experience)
Hours: Monday-Friday, 8:00am-5:00pm
Hiring Method: Multiyear contract - After 1 year on contract, the individual will have the opportunity to apply for a permanent role or have their contract renewed for another year
PTO: 10 PTO days, 6 paid sick days annually & paid Holidays
Benefits: Medical, Dental, Vision and 401K plans available
Exact compensation may vary based on several factors, including skills, experience, and education.
Benefit packages for this role will start on the 31st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.
Scientist - Imaging Research and Development
Research scientist job in Philadelphia, PA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
Organization Overview:
At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.
Responsibilities:
Lilly Imaging/Avid Radiopharmaceuticals provides technical expertise for molecular imaging to Lilly Research Laboratories. The scientist will provide expertise for biological assay development for the discovery and characterization of novel PET imaging agents, with a focus on neuroscience or oncology imaging and other therapeutic areas. This scientist will work independently, coordinating experimental details of internal and external partnered projects, conducting experiments him/herself, performing data analysis, and presenting data to internal teams and the international scientific community.
Establish and execute imaging research projects supporting oncology, neuroscience or other drug discovery and biomarker projects
Design and conduct novel binding assays, including radioligand binding assays
Characterize and purify biological targets
Collaborate with internal project teams, implement translatable imaging biomarker assays and ensure seamless translation of projects
Publish results of research projects as appropriate
Participate in extramural scientific organizations and attend scientific symposia as well as workshops in order to continue educational/professional development
Other duties as assigned
Basic Requirements:
Degree in physical or biological sciences or imaging-related field
Bachelor's degree with min of 10 years' experience or master's with a min of 8 years' experience in scientific field
Experience with in vitro assay development
Additional Skills/Preferences:
Experience with in vitro assay development
Experience in Oncology or Neuroscience, preferably in molecular imaging
Experience designing and executing novel biochemical, cellular and tissue assays, including radioligand binding assays (e.g. filtration binding, ELISA/AlphaLISA, SPR and LC/MS)
Experience working with amyloidogenic proteins
Demonstrated ability to independently conceive, design and execute the characterization and purification of biological targets
Experience in drug discovery of PET molecular imaging agents
Peer reviewed publications
Willingness/desire to learn and incorporate additional technologies or therapeutic area biology to address imaging needs
Peer-reviewed publications
Excellent communication skills (both written and verbal)
Excellent presentation skills
Strong organizational skills and ability to effectively manage multiple priorities
Creativity and critical thinking skills
Team Player
Additional Information:
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status
Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process, please email Lilly Recruiting Compliance. Please note, this email address is intended for use only to request a disability accommodation, please email Lilly Recruiting Compliance for further assistance. Inquiries which are not requests for accommodations may not receive a response.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (******************************************************** for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is
$63,000 - $162,800
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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Auto-ApplyResearch Associate -III
Research scientist job in Spring House, PA
Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost.
Job Description:
This position will support the Systems Pharmacology and Biomarkers Rheumatoid Arthritis lab-based group to assist with pharmacodynamic assay development for phase 1 clinical studies and sample processing and analysis for larger phase 3 clinical studies. The qualified candidate will perform high-throughput RNA isolation and associated QC procedures from a variety of clinical sample types as well as perform protein assays on clinical samples. They will also develop and execute cell-based assays to generate gene signatures of inflammatory disease pathways and use flow cytometry techniques to determine responses in individual cell types. The successful candidate must be able to work in a project-focused, matrixed team environment. The successful candidate will also be responsible for data analysis and interpretation using various computer programs, including MS Excel, GraphPad, etc, and have experience managing large sample libraries and data sets. The candidate must maintain a record of studies in the form of electronic notebooks, technical reports, summaries, and protocols. They will assist in maintaining laboratory instruments and supplies in a clean and safe laboratory environment.
ESSENTIAL FUNCTIONS: (Core Responsibilities)
• State-of-the-art knowledge in molecular and cellular biology is essential.
• Experience with the following techniques is required: ELISA (including MSD, Luminex, R&D Systems, etc), RNA isolation, Taqman qPCR, mammalian cell culture, and flow cytometry.
• Familiarity with proper Biosafety procedures for working with human samples is essential.
• Experience performing high-throughput analysis of human samples, including the use of laboratory automation is preferred.
• Must be highly organized and capable of handling several projects simultaneously.
• Good interpersonal communication skills needed. It is essential that candidate be self-motivated, productive and have excellent computer, communication, and scientific problem solving skills. Qualified candidates must have the ability to work independently and as part of a team.
LABORATORY SKILLS REQUIRED:
• ELISA
• Mammalian cell culture
• Flow cytometry
• RNA isolation
• PCR
• TaqMan
• Experience with human whole blood and blood products
• Laboratory Automation
• High-throughput screening
• High-content data analysis
Qualifications
REQUIREMENTS:
BS degree in Biology, Biotechnology or related field plus minimum 5 years additional laboratory experience, or MS with 2 additional years of laboratory experience.
Additional Information
Sneha Shrivastava
Technical Recruiter (Clinical/Scientific)
Artech Information Systems LLC
360 Mt. Kemble Avenue, Suite 2000 | Morristown, NJ 07960
Office: ************ | Fax: ************
Connect with us on - LinkedIn | Facebook | Twitter
Scientist- Biologics
Research scientist job in Exton, PA
Scientist, Biologics
Full-time
Frontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.
Responsibilities:
Primary responsibilities include, but are not limited to the following:
Perform analytical and biological sample testing
• Conduct method development and validation studies
• Perform immunoassay techniques: (ligand binding assays, ELISA, MSD, and/or RIA applicable to Pharmacokinetic and Immunogenicity studies), with proficiency
• Prepare and handle various cell lines, tissue culture media and other reagents for cell-based assays such as Neutralizing Antibody (NAb) assays
• Maintenance of instruments, and address technical and instrumental issues
• Assist the Principal Investigator with study conduct
• Maintain study documentation
• Meet regulatory compliance requirements
• Maintain a safe work environment
Requirements:
Bachelor's degree in related scientific discipline or Bachelors degree with relevant experience
• At least 2 years working in a laboratory preferred
Salary and Benefits:
Frontage Laboratories offers a competitive compensation and benefits package including health and dental insurance, a 401(k) plan, disability insurance, and life insurance.
Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.
Auto-ApplyResearch Associate-I
Research scientist job in Spring House, PA
The candidate should have a BS/MS in biological sciences with research experience in cellular immunology and/or cell biology including significant hands-on experience performing cell culture and following proper aseptic technique. The successful candidate will be able to apply different research techniques in the work including immune cell isolation, immune cell culture, ELISA, MSD, and luminex assays. Experience with assays using purified immune cells, T-cell culture, and hybridoma generation would be ideal. The candidate should have a good understanding of immunology and/or cell biology, be able work independently, have strong quantitative skills, and be familiar with basic data analysis software and data interpretation. Good organizational skills, experimental documentation, and a proven ability to work collaboratively in a fast paced, highly matrixed, interactive environment is essential.
Additional Information
Cell Therapy Process Development Scientist (Autologous)
Research scientist job in Spring House, PA
Our large pharmaceutical clients is seeking a Scientist to join their growing Process Development team within the Cell Therapy Development organization in Spring House, PA. This person will be focused on CAR-T cell manufacturing and will spend about 80% of their time in the lab setting up and running automation instruments for T cell manufacturing (primarily Prodigy), doing manipulation with cells, sampling, and making sure equipment is running properly. They will primarily be focused on process development in CAR-T and its transition to manufacturing. In this role, the successful candidate will be involved in process design, unit operation development, and parameter optimization studies resulting in the development of new production processes. Other responsibilities include:
Design and execute process development studies using sound scientific and engineering principles to develop and improve unit operations used for production of autologous T-cell therapies,
Identify, critically assess and evaluate opportunities to improve manufacturing outcomes such as improving success rate, throughput, reducing cost, process time and product quality of the final drug product.
Lead/contribute to the design and execution of phase-appropriate process development study plans, identifying process parameters and appropriate ranges to be assessed for optimal experimental design of the study.
Investigate improvements to current processes used for T-cell selection, activation, transduction and expansion together with their impact on critical quality attributes.
Author reports detailing experimental work and summarizing results, protocols, technical reports and SOPs.
Support technology transfer activities, writing protocols, reports, and performing and coordinating activities to support successful manufacturing
Qualifications:
Minimum of a Bachelor's Degree in a related field of study
Minimum of 2 years of process development for autologous cell therapy or CAR-T manufacturing
Prior experience working with bioreactors (preferably Xuri)
Salary: $80,000-$100,000 (flexible based on experience)
Hours: Monday-Friday, 8:00am-5:00pm
Hiring Method: Multiyear contract - After 1 year on contract, the individual will have the opportunity to apply for a permanent role or have their contract renewed for another year
PTO: 10 PTO days, 6 paid sick days annually & paid Holidays
Benefits: Medical, Dental, Vision and 401K plans available
Exact compensation may vary based on several factors, including skills, experience, and education.
Benefit packages for this role will start on the 31st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.
Research Associate- I
Research scientist job in Spring House, PA
Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost.
Job Description
Responsibilities
Applicant must be experienced with animal handling and be competent in basic laboratory skills.
Candidate would be responsible for the
planning and execution of in vivo studies in support of bacterial vaccine and monoclonal antibody R&D utilizing a variety of laboratory animals
according to the company s Institutional Animal Care and Use Committee guidelines.
The ideal applicant will be able to perform daily routine tasks efficiently and accurately, and is willing to learn new techniques.
Key responsibilities of the positions involve dosing and infection by various routes of administration, bleeding (interim and terminal), small animal surgery and harvesting of tissues for bacterial quantitation.
Calculating study endpoints, summarizing and recording data, and reporting of results would be required.
In addition to having strong in vivo skills, the candidate would ideally possess basic in vitro laboratory skills
encompassing microbiology, molecular biology, biochemistry and immunology.
Qualifications
BS, BA or MA in animal science, biology or related discipline required with a minimum of two years experience;
Hands-on experience with animal studies in the vivarium setting;
A current understanding of
basic animal models of infection
would be desired;
Experience in
basic in vitro laboratory skills (microbiology, molecular biology, biochemistry and immunology) preferred;
Experience with
vaccine development including immunological assays preferred but not essential;
Excellent computer, verbal and written communication skills;
Works well in a Team environment, but has the ability to execute studies independently;
Flexibility to travel between the Springhouse, PA (Home Base) and Raritan, NJ research facilities.
Additional Information
For more information, please contact
Sneha Shrivastava
Technical Recruiter (Clinical/Scientific)
Artech Information Systems LLC
360 Mt. Kemble Avenue, Suite 2000 | Morristown, NJ 07960
Office: ************ | Fax: ************
Connect with us on - LinkedIn | Facebook | Twitter
Scientist- Biologics
Research scientist job in Exton, PA
Job DescriptionScientist, Biologics
Full-time
Frontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.
Responsibilities:
Primary responsibilities include, but are not limited to the following:
Perform analytical and biological sample testing
• Conduct method development and validation studies
• Perform immunoassay techniques: (ligand binding assays, ELISA, MSD, and/or RIA applicable to Pharmacokinetic and Immunogenicity studies), with proficiency
• Prepare and handle various cell lines, tissue culture media and other reagents for cell-based assays such as Neutralizing Antibody (NAb) assays
• Maintenance of instruments, and address technical and instrumental issues
• Assist the Principal Investigator with study conduct
• Maintain study documentation
• Meet regulatory compliance requirements
• Maintain a safe work environment
Requirements:
Bachelor's degree in related scientific discipline or Bachelors degree with relevant experience
• At least 2 years working in a laboratory preferred
Salary and Benefits:
Frontage Laboratories offers a competitive compensation and benefits package including health and dental insurance, a 401(k) plan, disability insurance, and life insurance.
Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.