Research scientist jobs in Lynn, MA

Machine Learning Scientist - LLM Systems for Scientific Discovery About the Team Join the internal AI initiative of a prominent venture studio that has launched 100+ life sciences companies (including Moderna). You'll be part of a ~20-person technical team in Cambridge building advanced LLM and ML systems that accelerate scientific breakthroughs and help launch new AI-first ventures. What Will I Be Doing: Research & prototype novel LLM workflows (agents, reasoning systems, tool-use frameworks) tailored to scientific applications Define success metrics and design custom benchmarks to evaluate AI systems across diverse scientific domains Collaborate with ML engineers to scale promising prototypes into production systems Stay at the frontier by synthesizing state-of-the-art research and validating findings through rigorous experimentation Build feedback loops that incorporate user testing into system development What We're Looking For: PhD in machine learning, computer science, statistics, physics, mathematics, or related quantitative field Research excellence in LLMs or adjacent areas (reasoning/agents, sequence modeling, representation learning, optimization) demonstrated through publications at top venues or impactful work Hands-on ML experience with PyTorch or JAX, including reproducible experiment workflows Strong Python skills and fluency with standard ML tools Ability to work independently while collaborating effectively in a small team Experience building LLM systems: agentic frameworks, RAG, multi-agent simulations, RLHF/DPO, or evaluation methodologies Domain knowledge in chemistry, biology, physics, materials science, or related fields What's in it for me: Competitive Compensation: $140k-$240k dependent on experience Work on originating and fostering breakthrough ventures transforming human health and sustainability Relocation assistance available (typically $10k sign-on bonus) Apply now for immediate consideration!

Job Title: Principal Research Scientist VI Pay rate: $120-140/hr on w2 Duration: 12 Months (possible opportunity to convert to perm after contract term) About the Role We are seeking an experienced DMPK Project Representative to provide scientific leadership in the discovery and optimization of small-molecule drug candidates. This role leads DMPK strategy across multiple therapeutic areas and collaborates closely with cross-functional scientific teams. The ideal candidate is an ADME or PK/PD subject matter expert with a strong project-facing background and a track record of impactful scientific contributions. Top Skills 3+ years in a project-facing scientific leadership role Expertise in ADME and/or PK/PD modeling Strong publication/abstract history in metabolism, drug interactions, or PK/PD modeling Key Responsibilities Serve as the DMPK representative on global, cross-functional small-molecule project teams Provide expert guidance on experimental strategy, data interpretation, and DMPK strategy Lead internal and external research efforts supporting drug discovery Work closely with pharmacology, medicinal chemistry, and CRO teams Design, troubleshoot, and interpret complex DMPK experiments (in vitro, in vivo, in silico) Analyze sophisticated datasets and communicate findings to project stakeholders Ensure accurate documentation and contribute to scientific reports, manuscripts, and milestone documents Build collaborations with external scientific partners Represent the organization as a subject matter expert at scientific conferences Qualifications Bachelor's degree with 18+ years experience, OR Master's degree with 12+ years, OR Doctoral degree with 6+ years relevant post-doc/industry experience Deep understanding of ADME principles; PK/PD modeling or biotransformation experience preferred Experience working with outsourced or hybrid ADME models is a plus Strong communication skills-verbal, written, and cross-functional Ideal Candidate You thrive in a scientifically complex, highly collaborative environment and enjoy integrating DMPK strategy to advance drug discovery programs. You're comfortable leading projects, influencing cross-functional teams, and representing DMPK expertise internally and externally.

QUALIFICATIONS: • Bachelor's Degree within subject matter expertise required. • 18+ years' relevant experience required, or a master's degree with 12+ years' relevant experience, or a Doctoral degree with 6+ years' post-doctoral and/or industry-relevant experience can be considered. • Relevant required experience includes: Excellent understanding of ADME principles with knowledge of PK/PD modeling or biotransformation, highly desirable • Preferred experience includes: Prior experience working in a fully or hybrid ADME-outsourced models • Demonstrates excellent verbal and written communication skills. TOP SKILLS PER MGR: 1. Project-facing role (3+ years) 2. ADME or PKPD subject matter expert ESSENTIAL FUNCTIONS: • Function as DMPK project representative for global, cross-functional small molecule project teams to achieve project goals • Provide expert-level guidance to experimental plans and data interpretation with a strong expertise in either ADME/PK/DDI or PK/PD modeling and simulation • Troubleshoot highly complex tasks through independent and team-based efforts • Demonstrate deep subject matter expertise and in-depth experience, as well as creative, independent thinking and solutions for addressing critical scientific questions • Make independent decisions related to day-to-day experimental activities • Work closely with CROs to assume responsibility for DMPK experimental design, implementation, and interpretation • Analyze complex data with a high degree of sophistication, connect disparate datasets to reach conclusions, and communicate project updates and experimental results to relevant stakeholders • Ensure proper documentation of all experiments and data • Collaborative teamwork • Communicate regularly with international colleagues within the Client • Actively participate in cross-functional teams and meetings to drive project success • Achieve business goals, share learnings, knowledge, and skills & promote cross-functional teamwork • Share knowledge & expertise to expand team capabilities and goals • Demonstrate superior cross-cultural understanding to effectively interact with relevant stakeholders in the global organization • Write and review collaborative research manuscripts, project documents, and milestone documents • Complete assignments requiring expert-level knowledge of techniques and practices related to the research area • Represent the organization as NN-subject matter expert by attending and presenting at scientific conferences and global meetings

+++ SiPhox Health is redefining clinical immunoassay diagnostics by miniaturizing the analytical power of a central lab into an accessible, affordable, at-home platform. Our silicon-photonics architecture unites advanced biochemistry, microfluidics, and semiconductor-grade manufacturing to deliver precise, multiplexed biomarker quantification in minutes on a device the size of a coffee maker. We are building what we believe will become the first mass-market photonic blood analyzer, enabling continuous improvement in chronic disease management through frequent, high-quality testing. +++ The Opportunity +++ We are looking for a Senior Assay Development Scientist or Engineer who wants to build assays that have never been built on this kind of platform before. If you thrive on developing rigorous, quantitative immunoassays, including challenging free/competitive assays, and want your work to directly ship in a consumer device used by millions, this is one of the rarest opportunities in diagnostics today. This role sits at the center of platform innovation, contributing directly to analytical chemistry, surface chemistry, microfluidics, and silicon photonics integration. You will shape a growing assay menu that spans hormones, inflammatory markers, metabolic proteins, and future pediatric/specialty panels. +++ What You'll Do +++ Core Assay Development Develop quantitative sandwich and competitive immunoassays (including free hormone assays, displacement-driven formats, and low-abundance biomarkers) on a silicon-photonic resonance platform. Design, execute, and interpret experiments focused on: Binding kinetics & equilibrium optimization Surface functionalization strategies Competitive assay dynamic-range shaping Calibrator and control development (matrix selection, commutability) Assay precision, stability, robustness Analytical Performance & Validation Own assay verification and validation aligned with CLSI standards (EP05, EP06, EP07, EP09, EP10, EP17). Establish and demonstrate performance for: Analytical sensitivity & functional limit (LoB/LoD/LoQ) Linearity & reportable range (including hook effects, competitive assay inflection characterization) Repeatability, reproducibility, and nested CV analysis Interference and cross-reactivity studies Matrix equivalency & recovery studies Build calibration models for a novel platform (e.g., 4PL/5PL, competitive curve inversion, chip-specific normalization frameworks). Cross-Functional Integration Collaborate deeply with photonics, microfluidics, reader electronics, manufacturing, and product engineering teams to close the loop on real-world assay performance. Work with process development and chemistry groups to scale assays from prototype to production, enabling high-volume, chip-based manufacturing. Documentation & Execution Deliver high-clarity technical reports, protocols, V&V documentation, and design-history file content that meets IVD and FDA expectations. Present results across the company to inform design decisions and product milestones. +++ What We're Looking For +++ Technical Background PhD + 2 years, or MS + 6 years in biochemistry, chemical engineering, analytical chemistry, biophysics, bioengineering, or related fields. Expertise in immunoassay development (sandwich and competitive). Experience with free hormone assays is a major plus. Demonstrated ability to independently solve complex analytical and biochemical problems. Hands-on experience with complex analytical workflows, assay automation, and instrumentation. Strong understanding of calibration design, commutability, and control strategies. Familiarity with statistical analysis of assay performance, including mixed-model ANOVA, CV decomposition, and method-comparison frameworks. Regulatory & Platform Experience (Bonus) Experience with IVD development, ISO 13485, or 21 CFR 820. Experience with POC or novel-platform assay development. Knowledge of label-free sensors, waveguides, or photonic resonance systems. Experience with Python, R, or MATLAB for data analysis, curve fitting, and automation. Personal Traits Strong scientific intuition paired with rigorous data discipline. Thrives in a fast-paced, milestone-driven startup environment. Creative problem solver willing to challenge established assay paradigms. High integrity, willingness to own outcomes, and a collaborative mindset. +++ Why This Role Is Unique +++ Most assay developers spend their careers optimizing assays on platforms that already exist. At SiPhox, you will: Build the first generation of photonic immunoassays deployed in consumer health. Design assays whose constraints are shaped by semiconductor physics as much as biochemistry. Work on hard problems (free hormone assays, multiplexing, competitive equilibrium, small-volume matrices) where innovation, not incrementalism, wins. See your work ship in a product used at home by real people, not just research labs. If you want to work at the frontier of diagnostics (where photonics, biochemistry, and consumer health converge) we'd love to meet you.

Job Title: Biologist/Purification Scientist Duration: 12+ Months need only 1 to 4 years of exp with masters degree. Qualifications: Education: Master's degree in Biochemistry, Chemical Engineering, Biotechnology, or related field. Experience: Minimum 2 years of hands-on purification experience in an academic or industry setting. Technical Skills: o Strong knowledge and practical experience with ion-exchange and affinity chromatography. o Familiarity with buffer preparation. o Understanding of basic analytical methods for product characterization. Soft Skills: o Strong attention to detail and excellent documentation habits. o Effective communication and teamwork skills. o Ability to manage multiple tasks and meet project timelines. Preferred Qualifications Experience in AAV or other viral vector purification. Experience with AKTA systems and Unicorn software. Responsibilities: We are seeking a highly motivated Contractor - Purification Scientist to join our Downstream Process Development team. The successful candidate will contribute to the purification and characterization of viral vectors, biologics, or recombinant proteins to support process development and manufacturing activities. The ideal candidate has hands-on experience in ion-exchange chromatography, affinity purification, and tangential flow filtration (TFF), with a strong understanding of purification principles and data analysis. Key Responsibilities Execute purification processes including affinity chromatography (e.g., AVB, CaptureSelect), ion-exchange chromatography (AEX, CEX), and other polishing steps. Operate AKTA systems (Avant, Pure, or Pilot) for small- to large-scale purification runs. Perform TFF operations for buffer exchange and concentration of intermediate or final products. Support experimental design, data collection, and documentation following established procedures and GMP/GLP best practices. Assist in troubleshooting and optimization of purification processes. Analyze in-process and purified samples using relevant analytical methods (e.g., UV, SDS-PAGE, dd PCR, ELISA, or HPLC). Collaborate cross-functionally with upstream, analytical, and manufacturing teams. Maintain lab equipment, manage buffers and column inventory, and ensure compliance with safety and documentation standards.

MUST HAVES: Bachelor's degree in Food Science, Nutrition, or related field (Master's preferred; PhD or PharmD a plus). 5+ years of product development experience from concept to commercialization in nutrition, food, beverage, supplement, nutraceutical, or biotech industries. Previous experience in basic and applied research and development preferably in small/mid-sized nutrition, food, beverage and/or biotech company. Strong background in food science, ingredient interactions, and process impact on nutrient stability. Knowledge of food safety standards and aseptic processing

The Vlachos Lab and the Spatial Technologies Unit (************************** are currently looking for talented postdoctoral researchers to lead large-scale spatial/single cell initiatives within our research program as well as to devise novel AI/ML and computational biology methods that will enable us to bring these two novel technologies closer to translation. The researcher will have the ability to leverage some of the most extensive single cell and spatial transcriptomic datasets to date, generated in-house. Available projects revolve around cancer immunology, novel immunotherapies (CAR-T, bi-specifics, mRNA cancer vaccines), and autoimmunity research. We generate extensive data and employ, develop, utilize cutting-edge artificial intelligence and machine learning (AI/ML) to generate next-generation insights for novel targets or patient stratification. The Vlachos lab is also part of large scale initiatives, such as the Human Biomolecular Atlas Project (HuBMAP - ************************** enabling the postdoctoral researcher become an integral part of the single cell and spatial community. Local and International Applicants are encouraged to apply The Postdoc Single Cell and Spatial Technologies Bioinformatician will have the chance to be incorporated in cutting-edge research conducted in the Vlachos Lab, the Spatial Technologies Unit (**************************, in Beth Israel Deaconess Medical Center, Harvard Medical School, and the Broad Institute of MIT and Harvard. The position aims for candidates with a strong quantitative and computational background with extensive experience in genomics/transcriptomics (analysis of different bulk/single cell/spatial Next Generation sequencing Techniques as well as development of novel methods). A strong background in machine learning applications is considered a plus. Our location within the CRI, the first Institute for RNA Medicine in Boston, Harvard Medical School, and the Broad Institute of MIT and Harvard, creates a unique environment for avant-garde research and scientific growth. The researcher will receive training on research, grant writing, career development, and mentoring. She/he will have the opportunity to lead impactful projects and collaborate directly with an extensive network of leading researchers and companies in the US and internationally. Successful applicants will receive a competitive remuneration and benefits package. Essential Skills · Extensive experience in handling and analyzing Next Generation Sequencing data · PhD in a relevant subject area (Computational Biology, Population Genetics/Genomics, Bioinformatics, Biostatistics) · Strong quantitative background (e.g. BSc in Computer Science, Applied Math, Engineering, Biostatistics) · Experience in bioinformatics/data analysis using R/Bioconductor · Experience in linux-based environments and high-performance computing · Proven experience in AI/ML solutions · Great programming skills · Effective science communication Ideal Skills · Single cell and/or spatial -omics data analysis experience · Strong publishing record · Theoretical and practical AI/ML background · Lead and coordinate extensive projects For methods builders we also welcome links to github/bitbucket pages, and relevant bioinformatics/computational biology/machine learning community contributions. We are an equal Opportunity Employer and we welcome applications from women, persons with disabilities, protected veterans, and members of minority groups. International applicants are welcome to apply.'

Established nearly two centuries ago, FM is a leading mutual insurance company whose capital, scientific research capability and engineering expertise are solely dedicated to property risk management and the resilience of its policyholder-owners. These owners, who share the belief that the majority of property loss is preventable, represent many of the world's largest organizations, including one of every four Fortune 500 companies. They work with FM to better understand the hazards that can impact their business continuity to make cost-effective risk management decisions, combining property loss prevention with insurance protection. Join a world-class research team dedicated to reducing the impact of natural hazards and climate risks. FM is a market leader in commercial and industrial property insurance and loss prevention, serving over one-third of FORTUNE 1000 companies with engineering-based risk management and property insurance solutions. FM helps clients maintain business continuity through state-of-the-art engineering and research. The Structures and Geohazards Research Group at FM is seeking a creative and self-motivated Senior Research Scientist with a strong foundation in wind engineering and a specialized focus on computational wind engineering (CWE). The ideal candidate will possess deep expertise in fluid dynamics, high-performance computing, and wind tunnel testing, along with a demonstrated ability to conduct innovative, high-impact research. This role is integral to a strategic research initiative aimed at advancing the understanding of wind-related hazards and developing effective mitigation strategies. The successful candidate will contribute to cutting-edge projects that blend computational modeling with experimental validation to address real-world challenges in wind engineering. Responsibilities: Develop computational fluid dynamics (CFD) models to simulate wind flow around buildings and infrastructure, capturing complex aerodynamic interactions. Analyze wind loading on structures using high-resolution simulations; validate results with wind tunnel experiments or field measurements. Collaborate with interdisciplinary teams to incorporate wind effects into risk models, design standards, and resilience strategies. Publish and present research in peer-reviewed journals and at scientific or industry conferences. Contribute to strategic planning and innovation in wind engineering research initiatives. PhD degree. Mechanical, Civil, Aerospace Engineering or related fields. Hands-on experience with CFD software, both open-source (e.g., OpenFOAM) and commercial (e.g., ANSYS Fluent). Proficient in programming languages such as C++, Python, R, MATLAB. Skilled in high-performance computing (HPC) and parallel computing environments. Experience with wind tunnel testing or field measurements is highly desirable. Familiarity with relevant building codes and standards is a plus. Proven track record of publishing high-quality research and effectively communicating complex technical concepts to diverse audiences.Strong problem-solving abilities, creativity, and the capacity to work independently as well as collaboratively. The final salary offer will vary based on geographic location, individual education, skills, and experience. The position is eligible to participate in FM's comprehensive Total Rewards program that includes an incentive plan, generous health and well-being programs, a 401(k) and pension plan, career development opportunities, tuition reimbursement, flexible work, time off allowances and much more. FM is an Equal Opportunity Employer and is committed to attracting, developing, and retaining a diverse workforce.

About Us: SES AI Corp. (NYSE: SES) is dedicated to accelerating the world's energy transition through groundbreaking material discovery and advanced battery management. We are at the forefront of revolutionizing battery creation, pioneering the integration of cutting-edge machine learning into our research and development. Our AI-enhanced, high-energy-density and high-power-density Li-Metal and Li-ion batteries are unique; they are the first in the world to utilize electrolyte materials discovered by AI. This powerful combination of "AI for science" and material engineering enables batteries that can be used across various applications, including transportation (land and air), energy storage, robotics, and drones. To learn more about us, please visit: ********** What We Offer: * A highly competitive salary and robust benefits package, including comprehensive health coverage and an attractive equity/stock options program within our NYSE-listed company. * The opportunity to contribute directly to a meaningful scientific project-accelerating the global energy transition-with a clear and broad public impact. * Work in a dynamic, collaborative, and innovative environment at the intersection of AI and material science, driving the next generation of battery technology. * Significant opportunities for professional growth and career development as you work alongside leading experts in AI, R&D, and engineering. * Access to state-of-the-art facilities and proprietary technologies are used to discover and deploy AI-enhanced battery solutions. What we Need: The SES AI Prometheus team (AI Research) is seeking an exceptional Machine Learning Scientist to spearhead the development of our Large Language Models (LLM) and advanced AI agents. This role is pivotal in enabling groundbreaking research in machine learning for scientific discovery, particularly in the realm of material science and battery technology. * Harness internal expertise and collaborate with external research labs to advance scientific ML. * Work will be incorporated directly into our groundbreaking Deep Space multi-agent system for battery technology discovery. * This position can be remote. Essential Duties and Responsibilities: * Research & Development * Lead cutting-edge research in machine learning for scientific discovery, with a focus on (multimodal) Large Language Models and their application (including AI agents) in battery and material discovery. * Conduct groundbreaking research on integrating domain-specific data (including literature and internal documents) into LLM training and inference. * Investigate the mechanisms through which LLMs approach problem-solving, planning, and solution generation, particularly in the context of basic battery design questions. * Model Optimization & Implementation * Troubleshoot and optimize the training process of large language models, addressing complexities and challenges related to data quality, model architecture, and computational efficiency. * Implement innovative solutions to enhance model performance and scalability. * Collaborate closely with a multidisciplinary team to integrate findings into practical AI solutions that contribute to the discovery of new battery materials and the advancement of lithium battery technology. * Collaboration & Communication * Contribute to academic and industry discussions by publishing research findings in top-tier journals and presenting at conferences. * Engage in machine learning research aimed at addressing battery design challenges and enhancing system ability to interpret data-driven science efficiently. * The ability to communicate complex concepts clearly and effectively to both technical and non-technical team members. Education and/or Experience: * MS or PhD in Computer Science, Statistics, Computational Neuroscience, Cognitive Science or a related field, or equivalent practical experience. * Strong foundational knowledge and practical experience in Machine Learning, Deep Learning, and Large Language Models. * Proficiency in programming languages relevant to machine learning, with a strong preference for Python. * Experience with deep learning frameworks such as PyTorch or TensorFlow. * Proficiency in utilizing causal graphs for AI research and application. * A solid track record of innovative research, preferably with published work in relevant areas. * Excellent problem-solving abilities and a passion for tackling complex technical challenges. Preferred Qualifications: * Experience with AI applications in material science or battery technology. * Familiarity with the latest trends and methodologies in AI research, including algorithms such as GRPO.

The individual in this role will contribute to the advancement of neutral-atom-based quantum computing technologies. The individual in this role will be involved in the design, implementation, and characterization of neutral-atom quantum computing systems and collaborate closely with a multidisciplinary team of physicists, engineers, and computer scientists to push the boundaries of quantum computing using neutral-atom platforms. Responsibilities Design and build state-of-the-art neutral atom quantum computers. Collaborate with engineering teams to verify and validate modules and subsystems. Investigate sources of noise and decoherence and propose mitigation strategies. Analyze experimental data and draw meaningful conclusions to guide system improvements. Stay current with the latest advancements in AMO physics and quantum computing. Qualifications Ph.D. or equivalent experience in Physics or a related field, with a focus on Atomic, Molecular, and Optical (AMO) physics. Hands-on experience with quantum computing platforms and technologies. Proven experience working with neutral atoms, trapped ions, or other quantum systems. Proven experience architecting and integrating complex systems with both hardware and software components. Excellent problem-solving abilities and analytical skills, a self-starting, inventive attitude towards problem-solving. Effective communication and teamwork skills. Proficient programming skills in languages such as Python, C++, or similar. Track record of publications in reputable peer-reviewed journals. Proficient with Git, GitHub. The approximate base salary range for this position is $130,400 - $211,900. We consistently monitor external market data and update base salary ranges accordingly. We determine base compensation decisions on several factors, including as geographic placement, role-specific knowledge, skills, and/or experience. In addition to our base salary offerings, we also provide equity grants for all new hires. QuEra is committed to cultivating a diverse work environment and is proud to be an equal opportunity employer. We highly value diversity in our current and future employees and do not discriminate (including in our hiring and promotion practices) based on race, religion, color, national origin, gender, gender expression, sexual orientation, age, marital status, veteran status, disability status, or any other characteristic protected by law. #LI-NB1

Guggenheim is seeking an exceptional candidate to join as a sell-side Equity Research Associate to help cover the Biotechnology sector. This person will be responsible for following the progress of public/private Biotechnology companies and will support the research team in its efforts to analyze companies and make stock recommendations to institutional investor clients. In addition to a background in the life sciences, the ideal candidate will have a passion for stocks, interest in equity research and financial modeling, specifically in the Biotechnology sectors with a focus on oncology. The position is located in Boston, MA. Essential Job Functions * Provide support to the Senior Analyst through fundamental analysis and investment research in equity markets with an emphasis on original, bottom-up research in the Biotechnology sector * Analyze individual Biotechnology companies to build and update fully integrated financial and valuation models * Write comprehensive research reports and present findings; draft reports/notes on relevant investment themes, events and breaking news * Conduct primary research through industry sources including, but not limited to, financial analysis, due diligence clinical data and industry trends, company management and strategies * Organize physician calls for investors and investor events * Update analyst marketing handout regularly * Interact with Firm's institutional sales force and investor clients * Respond to client and internal inquiries regarding research findings and directives Preferred Qualifications * MD, PhD., or other advanced life sciences degree * 1-3 years of professional industry experience in industry, consulting, or similar * Exceptional analytical, verbal, and written communication skills * Analytical mindset, intellectual curiosity, aptitude for math/statistics Basic Qualifications * Bachelor's degree required * Ability to search, understand and interpret scientific and medical publications and presentations Work Location * Currently, this role is expected to be in the Boston office at least 4 days per week. Salary * Annual base salary between $140,000 and $165,000. * The base salary range represents the low and high end of the anticipated base salary range for this position. Actual base salaries may vary depending on factors such as location and experience. The range listed reflects base salary only, and the total compensation package may include other components such as incentive compensation. About Us: Guggenheim Securities is the investment banking and capital markets business of Guggenheim Partners, a global investment and advisory firm. Guggenheim Securities offers services that fall into four broad categories: Advisory, Financing, Sales and Trading, and Research. Guggenheim Securities is headquartered in New York, with additional offices in Chicago, Boston, Atlanta, San Francisco, and Houston. Guggenheim is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, sexual orientation, gender identity, national origin, disability, or status as a protected veteran. For more information, please visit GuggenheimSecurities.com, follow us on LinkedIn or contact us at ****************************************** or ************. About Us: Guggenheim Securities is the investment banking and capital markets business of Guggenheim Partners, a global investment and advisory firm. Guggenheim Securities offers services that fall into four broad categories: Advisory, Financing, Sales and Trading, and Research. Guggenheim Securities is headquartered in New York, with additional offices in Chicago, Boston, Atlanta, San Francisco, and Houston. For more information, please visit GuggenheimSecurities.com, follow us on LinkedIn or contact us at ****************************************** or ************. Guggenheim Securities, LLC ("GS") does not accept unsolicited resumes or applications. GS considers any resume or application to be unsolicited if (a) received from an entity or individual without a current recruiting agreement with GS or (b) submitted to anyone at the firm other than through the process set forth in the recruiting agreement between GS and the submitting entity or individual, and GS will not pay a fee to any entity or individual for such submission.

Responsibilities: Conducting proprietary research evaluating biotech companies' therapeutic pipeline by analyzing scientific literature, attending medical conferences, and consulting industry experts Writing research reports for initiations of coverage, analysis of data, deep dive in disease/ technology/ IP/ regulation/ policy, and industry/ company news Building and maintaining financial models Conceiving and executing on differentiated project ideas Interfacing with company management teams, internal sales and trading personnel, and institutional investors Candidate should understand that the team is highly motivated to become top-ranked in the biotech equity research Qualifications: ~1+ years of biopharmaceutical investment research, consulting, or industry; prior experience in biopharmaceuticals equity research with full license is a plus Motivated to rise in the sell-side industry in the long-term Advanced degree (PhD/MD/ PharmD) in life sciences preferred, though not required; a strong academic track record is essential Proficiency in written/verbal communication Experience building financial models using excel a required on-the-job skill; prior experience is a plus Motivated, hard-working, attention to detail, team player Can type >120 words per minute Primary Location Full Time Salary Range of $100,000 - $120,000.

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas! Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at **************** . Astellas Institute for Regenerative Medicine (AIRM) is a wholly-owned subsidiary of Astellas Pharma Inc and focused on the development and commercialization of stem cell and regenerative medicine therapies. Astellas is an R&D-driven global pharmaceutical company whose philosophy is to contribute to the improvement of people's heath around the world through the provision of innovative and reliable pharmaceutical products. AIRM has a world-class R&D team, and is pursuing a diverse range of disease indications, ranging from macular degeneration (currently in clinical trials) and other ocular indications to vascular and autoimmune disease. AIRM's intellectual property portfolio includes pluripotent stem cell platforms -- both embryonic and induced pluripotent stem cells as well as other cell-based therapy research programs. AIRM is headquartered in Massachusetts. Astellas is announcing a **Principal Research Associate, Cytogenomics** opportunity at their Astellas Institute for Regenerative Medicine (AIRM) site in Westborough, MA. **Purpose:** This role fills the critical business need of ensuring compliant laboratory methods within the realm of stem cell therapy development, and biologic and gene therapy quality control, while also making significant scientific contributions and advancing laboratory compliance to improve consistency and efficient delivery of results. The position aims to advance the development of stem cell-based therapies, biologics, and gene therapies across multiple therapeutic areas. **Essential Job Responsibilities:** + **Method Development, Qualification and Validation:** Support the development, qualification, and validation of methods for the analysis of stem cell products, biologics, and gene therapies, ensuring adherence to GMP standards and regulatory requirements. + **Documentation Excellence:** Establish and maintain compliant documentation practices for all qualification and validation activities, emphasizing meticulous record-keeping and compliance with regulatory guidelines. + **Scientific Contributions:** Make significant scientific contributions to the development of stem cell-based therapies through innovative experimental design, data analysis, and interpretation. + **Quality Assurance:** Implement and maintain a flawless approach to Quality Assurance, including regular audits, process improvements, and adherence to industry best practices. + **NGS Expertise:** Apply expertise in next-generation sequencing (NGS) to characterize stem cell products and elucidate underlying molecular mechanisms. + **Collaborative Research:** Collaborate effectively with cross-functional teams to integrate genomic analyses into broader research initiatives and therapeutic development projects. + **Continuous Improvement:** Drive continuous improvement efforts in assay performance, data analysis workflows, and documentation practices to enhance efficiency, accuracy, and regulatory compliance. + **Training and Development:** Provide training and mentorship to junior team members on method development and validation, documentation practices, and Quality Assurance principles + **Regulatory Compliance:** Ensure all qualification and validation activities comply with relevant regulatory requirements, including FDA and EMA guidelines for cell therapy products **Qualifications** **Required:** + BS with 10+, MS with 6+ or PhD with 1-2 years of laboratory experience. + Highly skilled in chromosome brightfield and FISH processing, analysis, and reporting + Highly skilled in cytogenetic and molecular biology principles such as microarray and STR Profiling + Excellent documentation practices and attention to detail + Leadership and mentorship capabilities + Strong knowledge of Quality Assurance and regulatory principles + Ability to effectively participate in cross functional collaboration and demonstrate excellent verbal and written communication skills + Excellent work planning, organization, and record keeping + ASCP certification or equivalent **Preferred:** + Experience with dd PCR and NGS methods and technologies + Familiarity with non-conformance, OOS, CAPA, and change control in the TrackWise digital platform + Familiarity with Quality Assurance principles and regulatory guidelines for cell therapy products + Familiarity with qualification of laboratory equipment **Working Conditions** + This position is based in Westborough, MA and will require primarily on-site work in a laboratory working environment. **Salary Range** **:** $91,000 - $143,000 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience and organizational equity considerations) **Benefits** **:** + Medical, Dental and Vision Insurance + Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down + 401(k) match and annual company contribution + Company paid life insurance + Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions + Long Term Incentive Plan for eligible positions + Company fleet vehicle for eligible positions + Referral bonus program \#LI-TD Category Integrative Science Astellas is committed to equality of opportunity in all aspects of employment. EOE including Disability/Protected Veterans

Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost. Job Description: • Possess a sound knowledge of the chemical principles and concepts of preparing buffers and tissue culture media and aseptic techniques . • Use established procedures (SOP's) and based on experience, training, and education, interpret complex methodologies (Protocols) provided by scientists. • Utilize good laboratory practices while applying technical expertise to formulate buffers and tissue culture solutions. • Independently perform work in a controlled laboratory environment. May assist others in completing their work. • Document all work utilizing Media Prep Worksheet • Maintain appropriate records pertaining to solution preparation in a fashion that allows for easy data retrieval. • Assist the team with the documentation such as records, reports and worksheets. • Assist with the shipping logistics of the buffer and media solutions. • Perform other applicable duties as deemed appropriate by lab supervisor / manager. Qualifications Additional Skills: 2+ years experience with laboratory operations in a hospital or pharmaceutical setting. Additional Information For more information, please contact Sneha Shrivastava ************

Clinical Research Investigator (MD/DO) DM Clinical Research, the largest privately-owned research management organization in the Houston area and one of the top 50 in the country, is looking for an Investigator for our site in Boston, MA. This individual will conduct all clinical trials (studies) according to ICH, GCP, local regulations, study protocols, and company processes. Responsibilities Ensures the medical well-being and safety of the participants through the safe performance and execution of the studies. Assists in maintaining clinical oversight and quality on the studies registered on and delivers on study targets, thereby contributing to the commercial success of the site. Reviews enrollment progress, pre-screening and screening success rates, screen failure rates, safety, and retention of participants. Interprets protocols and IB and participates in initiatives to strategize for patient recruitment. Carries out clinical evaluation and assessment of participants to ensure eligibility to enroll in studies. Ensures and protects the welfare and safety of participants through ethical conduct. Fulfills and complies with all medical duties as per protocol, SOP/COP and ICH GCP and local regulations. Exercises meticulous attention to detail in documentation and patient care. Requirements Medical license (MD, DO) - Boston 2 years experience as a Clinical Research Investigator (Principal Investigator or Sub-Investigator) Bilingual Spanish a plus Flexible hours - schedule can be tailored as required.

About Lux Lux Research is a leading research and advisory firm, helping clients navigate emerging technologies and drive growth through science-driven innovation. We sell to C-level executives in the world's largest companies. Our culture is high-energy, detail-obsessed and relentlessly focused on performance. If you thrive in a fast-paced, demanding environment where results, accountability and engagement matter, join our team for what may be the most rewarding job you have ever had. Role Description Lux Research is seeking a Research Associate specializing in Utilities to help define and advance our vision for the future of innovation in transmission and distribution networks for the power grid. The ideal candidate will possess a strong foundation in a STEM discipline related to utilities-such as electrical engineering, mathematics, power systems engineering, energy systems, or a related technical field-and a passion for applying scientific and technical expertise to strategic innovation questions. As a Research Associate at Lux, you will conduct and lead research that guides clients in understanding technological transformation within grid modernization including technologies enabling the power grid to carry more capacity with increased efficiency. You will develop thought leadership through writing analytical reports on emerging technologies and companies in the transmission and distribution system to deliver actionable insights which support investment, partnership, and strategy decisions for global electric utility leaders. Salary Range: $65,000 - $75,000 Responsibilities: · Lead research on emerging technologies shaping the utilities sector, including renewable integration, grid resilience, storage, electrification, and decarbonization technologies. · Develop and test research hypotheses, synthesize data from diverse sources, and produce findings that help clients navigate innovation opportunities. · Advise and support clients through written deliverables, direct consultations, and presentations, providing clear, evidence-based perspectives on technology and market trends. · Produce high-quality research reports and analyses that connect innovation in utilities to broader sustainability, regulatory, and consumer dynamics. · Represent Lux Research at industry conferences, webinars, and client events as a recognized thought leader in utilities and sustainable energy systems. · Collaborate with analysts across disciplines and geographic regions to deliver integrated insights on cross-sector innovation challenges, including digitalization, infrastructure modernization, and circular resource management. Requirements Minimum Qualifications: · Bachelor's degree in a STEM field related to utilities (e.g., electrical engineering, energy systems engineering, environmental science, applied physics, or related discipline). · 1-2 years of experience in the utilities, energy, or sustainability sectors, ideally involving technology analysis, R&D, or strategic consulting. · Demonstrated ability to analyze technical and market data, develop original insights, and communicate them effectively to business and technical audiences. · Exceptional writing and presentation skills, with experience crafting incisive, data-driven reports and delivering client presentations. · Strong quantitative and qualitative analytical skills, with the ability to translate complex scientific concepts into business implications. Desired Qualifications A Master's degree is highly preferred, especially with a STEM background in electrical engineering, energy systems, or related disciplines focusing on utilities processes. Intellectual curiosity and a deep interest in innovation, energy transition, and the future of utilities. Entrepreneurial and collaborative mindset, with a willingness to go the extra mile in a fast-paced environment. High degree of organization, attention to detail, and commitment to delivering high-quality research that drives impact. Lux Research is an Equal Opportunity Employer Lux Research is an equal opportunity employer. In accordance with anti-discrimination law, Lux prohibits discrimination and harassment of any type and affords equal employment opportunities to employees and applicants without regard to race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, genetic information, protected veteran status, or any other characteristic protected by law. Lux Research conforms to the spirit as well as to the letter of all applicable laws and regulations. law. Lux Research conforms to the spirit as well as to the letter of all applicable laws and regulations. Salary Description $65,000 - $75,000

General information Location Cambridge, MA Ref # 43395 Job Family Research Date published 12/09/2025 Time Type Full time Pay Range 100,000 - 140,000 Usd Annual Description & Requirements The Broad Institute of MIT and Harvard is the world's leading biomedical research institute dedicated to the bold mission of using the full power of genomics to transform the understanding and treatment of disease. We seek to describe all of the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods, and data openly to the entire scientific community. We are seeking a highly motivated and innovative scientist to lead collaborative initiatives in partnership with the Cancer Dependency Map and Cancer Cell Line Factory programs and the Sellers and Getz labs at the Broad Institute. The primary goal of this role is to develop advanced laboratory cellular models to enable functional genomics, drug screening, and drug resistance studies. Our current focus is on deriving 3D models for pediatric and rare cancers, with an initial pilot to generate cancer-resistant cell lines for major oncology drugs. This work will lay the foundation for expanding cancer cell line diversity through additional grant funding and external collaborations. The ideal candidate will be a proactive, curious scientist with a strong background in cell biology, patient-derived cancer models, drug resistance research, and platform development. This position also offers the opportunity to build leadership skills while working closely with Senior Group Leaders. Qualified candidates should have: A Ph.D.in a biological science (such as cell biology, biochemistry, cancer biology, or a related field) and a completed or soon-to-be-completed postdoctoral fellowship in a similar field. 2+ years of experience as a postdoc or in the industry. Excellent organizational and time management skills with strong attention to detail. Experience in cell biology with a focus on method development, team management, and mentoring junior research associates is highly desirable. Required Skills: Self-motivated and curious, with the ability to lead scientific research effectively. Demonstrated excellent problem-solving and communication skills with leadership, colleagues, and junior research associates. Track record of independently delivering scientific results. Expertise in molecular and cell biology techniques, including flow cytometry, immunofluorescence staining, Western blotting, ELISA, HTS cell culturing, 3D cell culturing, drug testing, etc. Impeccable and efficient experimental design, assay development, and execution. Strong commitment to "leading from the bench". Excellent interpersonal, written, and oral communication skills, perform detailed data analysis, and accurate record-keeping to support the cell model team members. Extensive experience in following and improving assay protocols is preferred. Responsibilities: Lead experimental design for cell model development, implement newly developed protocols, and conduct proof-of-concept studies to evaluate feasibility and optimize workflows. Serve as the technical lead and subject matter expert for cell model development efforts, driving strategic improvements to enhance efficiency, success rates, and overall platform capabilities. Validate cell models through sequencing technologies and oversee model fidelity assessments using flow cytometry, immunofluorescence, western blotting, and other relevant assays in collaboration with internal Scientists and Research Associates. Lead drug resistance modeling projects to establish oncology drug-resistant clones for functional genomics analyses. Manage and mentor Research Associates, fostering scientific and professional growth while ensuring high-quality data generation. Collaborate with Sellers Lab, Getz Lab, Cancer Dependency Map, PRISM drug screening, Cancer Genomics, and Cancer Data Sciences teams to advance research initiatives and share expertise. Coordinate closely with cancer genomics core staff to integrate experimental data with genomic insights for comprehensive analysis and interpretation. Identify opportunities for platform innovation and expansion to address emerging scientific needs and challenges. Partner with internal teams on large-molecule discovery and validation efforts to support broader oncology research goals. The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law. At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits. The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations. Should you need a reasonable accommodation to complete the application or interview process, please contact ***************************** for assistance.

About this opportunity : As a Research Scientist I you will be responsible for meeting the analytical testing requirements to support research and development projects primarily focused on oligonucleotides. Key Responsibilities: * Execute testing per method or protocol for development, qualification, verification, validation, and transfer of analytical methods * Analyze test samples, process data, and report results with minimal errors to support research and development primarily focused on oligonucleotides * Provide analytical support to Process Development and Manufacturing * Design and perform method development experiments * Perform GDP and technical peer review * Author technical documentation (e.g., methods, procedures) * Provide technical leadership in analytical project meetings * Maintain laboratory compliance * Provide basic-level training in lab techniques and procedures * Plan, track, and execute tasks to deliver project results on time * Communicate with clients and elevate issues to project team leader * Contribute to department objectives for continuous improvement and technical excellence * Contribute to a positive work atmosphere Required Skills/Abilities: * BA/BS with 2+ yrs. of related experience * MS with 1+ yrs. of related experience * Perform any laboratory procedure * Operate and troubleshoot KF, U/HPLC instruments * Knowledge of undergraduate general and organic chemistry * Analytical chemistry knowledge including theory and application of fundamental analytical techniques for identification, purity, and assay * Basic Word, Excel, and PowerPoint * Perform algebraic and basic statistical calculations correctly * Proficient in technical writing and department-wide presentations * Understand and edit laboratory SOPs The annualized salary range for this position is $84,400.00 - $103,300.00.

: As a Research Scientist I you will be responsible for meeting the analytical testing requirements to support research and development projects primarily focused on oligonucleotides. Key Responsibilities: Execute testing per method or protocol for development, qualification, verification, validation, and transfer of analytical methods Analyze test samples, process data, and report results with minimal errors to support research and development primarily focused on oligonucleotides Provide analytical support to Process Development and Manufacturing Design and perform method development experiments Perform GDP and technical peer review Author technical documentation (e.g., methods, procedures) Provide technical leadership in analytical project meetings Maintain laboratory compliance Provide basic-level training in lab techniques and procedures Plan, track, and execute tasks to deliver project results on time Communicate with clients and elevate issues to project team leader Contribute to department objectives for continuous improvement and technical excellence Contribute to a positive work atmosphere Required Skills/Abilities: BA/BS with 2+ yrs. of related experience MS with 1+ yrs. of related experience Perform any laboratory procedure Operate and troubleshoot KF, U/HPLC instruments Knowledge of undergraduate general and organic chemistry Analytical chemistry knowledge including theory and application of fundamental analytical techniques for identification, purity, and assay Basic Word, Excel, and PowerPoint Perform algebraic and basic statistical calculations correctly Proficient in technical writing and department-wide presentations Understand and edit laboratory SOPs The annualized salary range for this position is $84,400.00 - $103,300.00.