Research scientist jobs in Providence, RI - 1,348 jobs

A global biotechnology company seeks an experienced Associate Principal Scientist to support in vitro pharmacology projects. The role involves collaborating with pharmacologists, managing CRO relationships, and assessing external resources for early drug discovery. The ideal candidate should possess a relevant Bachelor's degree and extensive industry experience. A hybrid work model is offered. Competitive salary range from $144,800 to $227,900 annually. #J-18808-Ljbffr

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A biotechnology company in Waltham, MA is seeking a Principal Scientist in ADME-PK to enhance drug delivery to muscle and CNS tissues. The successful candidate will design preclinical studies, author regulatory documents, and collaborate across various teams. Candidates should possess a PhD in a relevant field and over 6 years of industry experience, with expertise in pharmacokinetics and drug metabolism. This role offers a competitive salary in the range of $159,000 to $195,000 USD depending on experience. #J-18808-Ljbffr

A leading healthcare institution in Boston seeks a Sr. Principal Scientist to oversee operations in a GMP lab, focusing on the production and quality control of radiopharmaceuticals. The ideal candidate will have extensive experience in aseptic operations, knowledge of QC methodologies, and a strong educational background in pharmaceuticals. This role requires meticulous documentation, adherence to GMP standards, and the ability to thrive in a fast-paced environment, contributing to pioneering advancements in patient care. #J-18808-Ljbffr

Applied Physical Sciences (APS) is looking for a highly motivated Physical Scientist to join the Concord, MA team in a part-time, on-call (PTOC) position. Successful candidates will have a PhD in theoretical physics, expertise in inverse theory or tomography, and will support the development of state-of-the-art technologies for tomographic imaging with irregular experiment apertures, with a special emphasis on exploitation of high energy X-rays. APS works on exciting, technically challenging, cutting-edge technologies that will expose candidates to a wide variety of multidisciplinary fields, providing a stimulating environment with considerable opportunity for collegial interaction. At APS you will work in a small company environment where technical excellence is rewarded and an entrepreneurial spirit is encouraged, and you will have the chance to work directly with colleagues and customers that value innovation and creativity. Responsibilities Theoretical modeling of x-ray interaction physics, development of X-ray inversion paradigms for highly challenging experiment scenarios, rigorous characterization of the fundamental information limits of X-ray imaging. Software implementation of processing and modeling techniques, numerical execution of synthetic inversion experiments, display and quantification of model uncertainty Required Attributes and Skills PhD in theoretical physics, and expertise in modeling and inversion of X-ray data Subject matter expertise in one or more of the following: advanced numerical optimization, statistical methods, experiment design optimization, GPU-based computing Extensive experience with computational methods and programming for modeling physical phenomena and processing of real data e.g., Matlab, Python, PyTorch, or Fortran Exceptional communication skills (written and oral) for technical documentation and reviews with customers Desired Attributes and Skills Professional experience of 10+ years in DoD or related industry, a strong publication history in refereed technical journals, and a track record of successful performance on research programs under DARPA, IARPA, NAVSEA or ONR sponsorship is preferred. Experience as principal investigator working on advanced R&D programs Demonstrated technical leadership in modeling and simulation Expertise in one or more of the following: mathematical physics, model-based iterative methods for x-ray tomography, Monte Carlo radiative transport methods for Bremsstrahlung modeling, advanced numerical optimization techniques involving both continuous and discrete variables, regularization methods, uncertainty quantification using the Fisher Information Matrix and the Cramer-Rao Bound, and multi-objective optimization. Experience presenting talks at technical conferences APS, a wholly owned subsidiary of the General Dynamics Corporation, offers a small company environment including competitive salary, excellent benefits, and comfortable working conditions. This is a part-time on-call position open in the Concord, MA office. Candidates must possess or be able to obtain a Top Secret DOD security clearance. Qualified applicants are invited to submit a resume and application online at **************** fax them to ************, Attn: Human Resources, or mail to the company address. Please reference the requisition number and title of the position in the subject line of your submission. Equal Opportunity Employer/M/F/Disability/Protected Vet Invitation to Self-Identify In keeping with our commitment to Equal Employment Opportunity (EEO), Applied Physical Sciences invites all applicants to self-identify pre-offer as a protected veteran and/or an individual with a disability. Invitation to Self-Identify as Protected Veteran Online Form Invitation to Voluntary Self-Identification of Disability Online Form #J-18808-Ljbffr

Title:- Research Associate I Duration: Contract until Feb 2027 (Possible extension) Overview/Department Description We are seeking a contract upstream Research Associate to join our Cell Culture Platform group in Cell Culture Development department (CCD-CCP). CCD-CCP is a global business unit responsible for the development of cell culture platforms including media and bioprocess technologies for both fed-batch and perfusion from early and late-stage biologics projects, as well as all upstream CMC development activities for early phase projects (up to Phase II). The candidate will be self-motivated and strongly driven to succeed while demonstrating the ability to function well within a fast-paced and collaborative team-oriented environment. The candidate will also be inquisitive and innovative, exhibiting scientific curiosity and the ability to acquire new skills for fed-batch and perfusion based upstream cell culture processes. This is an exciting opportunity to learn cutting-edge cell culture techniques and develop cell culture subject matter expertise. This role will have significant impacts on early pipeline projects, next generation cell culture process development and manufacturing strategies within the global *** network. Main Duties & Responsibilities • Require to be on site daily; Weekend work required occasionally. • Plan and execute experiments to optimize upstream cell culture platform process at different scales (shake flasks, AMBR, 3L/10L bioreactors, etc.) • Perform upstream experiments and collaborate with other functional groups to speed Phase I pipeline projects • Contribute to technical reports, experimental protocols, and technical summaries for presentation internally and externally • Participate in the technology transfer of processes into manufacturing facilities • Ensure safety and environmental compliance are maintained in the workplace • Some weekend working may be required for this role Basic Qualifications • Bachelor or Master's degree in Chemical Engineering, Biochemical Engineering, Cell Biology, Biochemistry or a related discipline • Post-education experience ?=3 years • Understanding of aseptic technique and principles of mammalian cell culture • Detailed in lab operations and quick learner for new technologies Preferred Qualifications • Experience in the operation of fed-batch and/or perfusion-based cell culture bioreactors • Knowledge of CMC MINAKSHI SANGWAN Recruiting Lead - US Recruitment O ************ E *************************** W **********************

Immediate need for a talented Research Associate I. This is a 06+ Months Contract opportunity with long-term potential and is located in Framingham, MA (Onsite). Please review the job description below and contact me ASAP if you are interested. Job ID:26-01448 Pay Range: $34 - $44/hour. Employee benefits include, but are not limited to, health insurance (medical, dental, vision), 401(k) plan, and paid sick leave (depending on work location). Key Responsibilities: Require to be on site daily; Weekend work required occasionally. Plan and execute experiments to optimize upstream cell culture platform process at different scales (shake flasks, AMBR, 3L/10L bioreactors, etc.) Perform upstream experiments and collaborate with other functional groups to speed Phase I pipeline projects Contribute to technical reports, experimental protocols, and technical summaries for presentation internally and externally Participate in the technology transfer of processes into manufacturing facilities Ensure safety and environmental compliance are maintained in the workplace Some weekend working may be required for this role. Key Requirements and Technology Experience: Must have skills: - Understanding of aseptic technique and principles of mammalian cell culture, Cell culture platform process at different scales (shake flasks, AMBR, 3L/10L bioreactors, etc.) Bachelor or Master's degree in Chemical Engineering, Biochemical Engineering, Cell Biology, Biochemistry or a related discipline Post-education experience ?=3 years Understanding of aseptic technique and principles of mammalian cell culture Detailed in lab operations and quick learner for new technologies. Experience in the operation of fed-batch and/or perfusion-based cell culture bioreactors Knowledge of CMC Note- Weekend works is required and is occasionally. This is a rotating, schedule 1-4 hours on 1 weekend day and will include a Saturday or Sunday. This will be included in 40 work week and no to exceed 40 hours. Weekend work is pre-planned through end of year; new hire can swap with colleagues if available. Our client is a leading Pharmaceutical Industry, and we are currently interviewing to fill this and other similar contract positions. If you are interested in this position, please apply online for immediate consideration. Pyramid Consulting, Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. By applying to our jobs you agree to receive calls, AI-generated calls, text messages, or emails from Pyramid Consulting, Inc. and its affiliates, and contracted partners. Frequency varies for text messages. Message and data rates may apply. Carriers are not liable for delayed or undelivered messages. You can reply STOP to cancel and HELP for help. You can access our privacy policy here.

Prepare injectable (parenteral) peptide and protein formulations to support in vivo and in vitro animal studies, including buffer, excipient, and surfactant selection Execute preclinical formulation development activities to support early research and screening programs Perform biophysical characterization and stability studies to assess formulation performance and robustness Support animal dosing studies by preparing, documenting, and delivering study-ready formulations Maintain accurate experimental records using ELN (Electronic Laboratory Notebook) and manage formulation requests/workflows Operate, maintain, and troubleshoot formulation, biophysical, and analytical laboratory instruments Analyze experimental data and contribute to scientific documentation and reporting Collaborate closely with cross-functional research teams to resolve formulation challenges and meet project timelines

A leading cancer research institute is seeking a Higher Scientific Officer specializing in assay development and compound profiling. The successful candidate will apply screening science to advance cancer drug projects, developing plate-based assays to identify small-molecule inhibitors. This position offers a dynamic research environment supported by state-of-the-art facilities, a collaborative team, and competitive compensation. Ideal candidates will have laboratory experience and an understanding of enzymology, along with skills in automation equipment. #J-18808-Ljbffr

About the job: SciPro is partnered with a fast growing Scientific Data and AI platform startup who is searching for a Senior Applied AI/ML Engineer to join their team. They are catalyzing the Scientific AI revolution by designing and industrializing AI-native scientific data across the scientific value chain and scientific vertices. They bring this AI data to life in a fast growing suite of universal lab data management solutions, scientific use cases, and AI-based scientific outcomes. Requirements: You will be a critical team member in a unique partnership to industrialize Scientific AI. As such, you will engage directly with customers onsite up to 4-5 days per week in the Boston region. Advanced degree in Biological, Data, or Computer Science Portfolio demonstrating end-to-end ownership of AI/ML products Proven track record of deploying AI models addressing real world problems Experience in biotech, biopharma, or pharma-adjacent projects Superior talent developing at least one of: ML-Reinforcement Learning, LLM/NLP, or Protein Design/Diffusion Models Responsibilities: Responsible for designing, developing, training, and validation of AI/ML products Support and advise executive leadership regarding technical and commercial feasibility Work with commercial teams to understand the impact of AI in life-sciences Collaborate with cross functional teams to build products Preferred Qualifications: Deep understanding of hurdles facing pharmaceutical drug development Demonstrated ability to make productized applications (for use by more than one group) Excellent communication skills Ability to advocate and evangelize for AI initiatives internally and externally Experience collaborating with teams on large software projects

Nextcea Inc. is a pharmaceutical services company that focuses on assessing drug efficacy and safety during late-stage drug development and clinical trials. We are currently seeking full-time Analytical Chemists to join our team. Qualified candidates will actively participate in LC-MS biomarker analysis at Nextcea. Successful applicants should hold an MS or PhD in Analytical Chemistry or a related field, along with relevant laboratory experience. While experience with LC-MS is preferred, it is not mandatory. We are seeking self-motivated candidates who are excellent team players and can effectively contribute to established laboratory procedures and protocols. Candidates should be able to work independently, demonstrate flexibility, and adapt to the challenges of pharmaceutical biomarker projects. At Nextcea, we value diversity and inclusion. We offer competitive compensation and benefits, including medical, vision, dental, and 401(k) plans, to all employees, regardless of their background or identity. Applicants are required to submit their resumes online via LinkedIn.

A prestigious research institution in Boston is seeking an Associate in Biomedical Informatics to support biomedical research training and projects. The role involves developing knowledge graphs, conducting data analyses, and writing research reports under the guidance of experienced mentors. Applicants should have a Bachelor's degree in computer science and a keen interest in healthcare technologies. #J-18808-Ljbffr

Job Title: Research Associate/Sr. Research Associate, Discovery Biology/Drug Discovery Institute: Institute of Organic Chemistry and Biochemistry (IOCB) Boston Position Type: Full-Time, In-Person / Laboratory-Based (no remote work) Classification: Exempt -- This position is classified as exempt and involves advanced professional duties requiring specialized knowledge in a scientific field. About the Position The Institute of Organic Chemistry and Biochemistry (IOCB) is expanding its presence in the Boston area and is seeking a Research Associate or Associate Scientist to join our Drug Discovery team. This role offers a unique opportunity to contribute to both hypothesis-driven basic research and early pre-clinical drug discovery efforts. The ideal candidate is highly hands-on and intellectually curious, with strong experience in cell biology, molecular biology, and biochemistry, and an interest in building robust assays and generating high-quality data to support target validation and drug discovery. Key Responsibilities Experimental Design & Execution Under the guidance of the Head of Drug Discovery, independently plan and execute experiments, analyze data, and clearly communicate results in team meetings and to external collaborators. Maintain rigorous documentation and reproducibility standards (e.g., controls, repeatability, robust assay performance). Collaborative Drug Discovery Research Partner closely with interdisciplinary colleagues (proteomics, protein science, computational, external academic collaborators) to advance target validation, mechanism-of-action studies, and early discovery programs. Contribute to project planning, experimental prioritization, and interpretation of results in a drug-discovery context. Assay & Method Development Develop, optimize, and validate cellular and biochemical assays (e.g., potency, selectivity, pathway readouts). Support screening workflows and follow-up characterization of hits. Leverage and/or help expand capabilities in discovery biology, proteomics, biophysics, and protein science as needed. Required Qualifications Education & Experience Research Associate: Bachelor's degree with relevant research experience Sr. Research Associate: Master's degree with relevant research experience Core Competencies Strong hands-on experimental ability in one or more of: cell biology, molecular biology, biochemistry, biophysics Self-directed, organized, and motivated; able to work effectively both independently and in a collaborative team environment Strong written and verbal communication skills with attention to detail and data integrity Technical Expertise (or Strong Willingness to Learn) Drug Discovery Biology: biochemical and/or cell-based assay development; screening support; basic screening data analysis; data organization and tracking Molecular Biology: cloning, mutagenesis, PCR/Gibson, RT-qPCR, Western blotting; experience with CRISPR/Cas9 a plus Software & Data: proficiency with GraphPad Prism and Microsoft Office (Word/Excel/PowerPoint); familiarity with Python for data analysis is a plus Preferred Qualifications Prior experience in an academic or industry drug discovery environment (target validation, assay development, screening, hit follow-up) Experience working with compound libraries and follow-up screening logistics Demonstrated interest in translational science and using modern tools/technologies to answer biological questions Salary Range: Research Associate $69,000 - 71,000 USD per year, Sr. Research Associate $75,000 - 90,000 USD per year. The salary range listed represents IOCB Boston's good faith estimate for this position and is based on factors including, but not limited to, education, experience, skills, internal equity, and market data. Final compensation will be commensurate with qualifications and experience. Benefits: Competitive benefits package including employer-subsidized medical, dental, and vision insurance; transportation contribution; generous paid time off; and company-paid Accidental Death & Dismemberment (AD&D), Short-Term Disability (STD), Long-Term Disability (LTD), and life insurance. Work Authorization/Visa Sponsorship: IOCB Boston does not sponsor employment-based visas for this position. Candidates must be legally authorized to work in the United States at the time of hire and must maintain work authorization throughout the duration of employment without the need for current or future employer sponsorship. Employment eligibility will be verified in accordance with federal law. IOCB Boston participates in the federal E-Verify program. Employment offers are contingent upon the successful completion of a background check conducted in accordance with applicable federal and Massachusetts laws Why Join Us You'll join a collaborative and ambitious team working at the interface of basic biology and early drug discovery. This role provides meaningful ownership of experiments and methods, opportunities to work across disciplines, and the chance to contribute to high-impact science in a fast-moving, supportive environment. TO APPLY: Please email ********************************* to express your interest. Include your most recent curriculum vitae or resume as well as a cover letter that describes your interest in this position. Direct applicants only. IOCB Boston does not accept unsolicited resumes from recruitment or employment agencies. Equal Employment Opportunity Statement IOCB Boston is an Equal Opportunity/Affirmative Action Employer. We are committed to providing equal employment opportunities to all qualified applicants and employees without regard to race, color, religion, sex, sexual orientation, gender identity or expression, age, national origin, disability, protected veteran status, genetic information, or any other status protected by applicable law.

Vaxess is developing a pipeline of next-generation therapeutics on our novel micro-array patch platform. With only five minutes of wear-time on the skin, the Vaxess' patch combines room temperature stability with simplified application to dramatically alter the way that drugs are delivered. Vaxess is committed to enabling products that are not only more effective, but also more accessible to patients around the world. The Role We are seeking a motivated and detail-oriented Research Associate with strong hands-on experience in chromatographic analysis to support QC release and stability testing. The successful candidate will perform routine cGMP QC testing using HPLC methods (RP-HPLC, SEC, IEX), Agilent HPLC systems, and additional supporting assays in a fast-paced, collaborative environment. This is a unique opportunity to be part of an emerging early-phase clinical company bringing innovative technology to the global market. Key Responsibilities Perform routine QC release and stability testing using HPLC methods including RP-HPLC, SEC, and IEX. Prepare samples, operate Agilent HPLC systems, verify system suitability, and ensure analyses meet method and specification requirements. Execute complementary analytical assays such as UV-Vis, pH, surface tension, and mechanical tests. Maintain complete, accurate documentation in compliance with cGMP, ALCOA+, and data integrity requirements. Conduct routine instrument care (solvent flushes, column care, daily checks) and assist troubleshooting under supervision. Process and review chromatographic data in Agilent OpenLab CDS. Support method qualification, validation, and transfer activities by executing protocols and recording observations. Maintain calibration, maintenance, and service records for analytical instrumentation. Independently author method SOPs, analytical protocols, technical reports, and contribute to regulatory submissions. Collaborate cross-functionally with QC, Analytical Development, Process Development, Manufacturing, and Regulatory teams to enable program success. Maintain rigorous laboratory documentation and complete, audit-ready analytical records. Thrive in a fast-paced, cross-functional environment with excellent communication and organizational skills. Qualifications Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or related field with 1-3 years of experience; or a master's degree with relevant laboratory experience. Hands-on experience operating HPLC systems; Agilent systems and OpenLab CDS experience strongly preferred. Practical experience with chromatographic techniques including RP-HPLC, SEC, and IEX. Experience supporting QC release or stability testing in a GMP/GLP environment. Strong attention to detail and ability to follow SOPs precisely. Excellent documentation practices and understanding of data integrity. Strong organizational skills with the ability to manage multiple workflows and prioritize effectively in a fast-paced environment. Excellent verbal and written communication skills and comfort working within interdisciplinary teams. Commitment to collaborative work within interdisciplinary project teams. At Vaxess, we're bringing together exceptional talent to drive our product development forward. We value collaboration, curiosity, and a dynamic work environment. To apply, please submit your CV/resume to ****************** .

A consulting firm specializing in healthcare seeks a Senior Consultant in Boston, MA. The role involves managing research efforts, mentoring junior consultants, and providing strategic insights to clients. Candidates should have an advanced degree or relevant experience in life sciences consulting, strong data synthesis abilities, and excellent communication skills. The position offers a competitive salary starting at $128,000 plus bonus potential, making it an attractive opportunity for professionals in the biopharmaceutical industry. #J-18808-Ljbffr

A cancer research organization in Boston seeks a Principal Artificial Intelligence & Machine Learning Engineer I/Scientist I. This role involves collaborating with physician scientists and leading research efforts. The ideal candidate has a Master's degree, 8+ years of experience in AI/ML, and strong Python skills. The position requires problem-solving abilities, team collaboration, and experience in clinical or research environments. A commitment to diversity and inclusion is essential for this role. #J-18808-Ljbffr

Industry: Pharmaceuticals Title: Senior Associate Scientist Duration: 12 months contract (+Possibility of extension) Job Description: The Senior Associate Scientist, Specifications will be responsible for specification support of si RNA drug substances and drug products. This is an onsite position. Summary of Key Responsibilities: • Initiate and manage specification change controls in a GMP setting. • Expected contributions to general operations including review of data and authorship/review of technical documentation. Provide technical support as needed. • Author and review SOPs and protocols in accordance with company and regulatory guidelines. • Contribute to data review, analytical and stability sections of regulatory submissions. Assist with responses to agency requests on these sections. • Contribute to specification assessment of existing and new products. • Provie support in maintaining platform program specification documents Accountabilities • Meet goals supporting studies and defining specifications for new molecules in development. • On-time and compliant completion of review and verification of stability data to support clinical supply. • Implementation of stability and release specifications for product registration. • Adhere to core values. Knowledge/Experience/Skill: • BS or MS in Chemistry, Biochemistry or related disciplines. • Minimum of 2 years of previous experience in a cGMP analytical laboratory environment. • Preferred previous experience with stability studies designed and conducted in accordance with ICH guidelines. • Must be a team player and open to change. • Must have excellent communication and speaking skills. Can prepare presentations and present. • Preferred - experience with HPLC and physico-chemical test methods of oligonucleotides. Alternatively - experience with HPLC and physico-chemical test methods of oligosaccharides or proteins. Scope The Senior Associate Scientist Specifications will be responsible for specification support of developmental and clinical si RNA drug substances and drug products. Physical/Environmental Factors (Complete if appropriate for role) • Must be able to adhere to all laboratory safety requirements • Must be able to travel between sites Competencies • Ability to write clear technical documents and provide meaningful presentations. • Ability to work independently and in compliance with company policies and regulatory guidelines. • Excellent team skills, organization, and strong interpersonal communication skills (written and verbal)

Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. Responsibilities Partner with our pharma clients to design, develop and execute computational research leveraging the Tempus platform to advance drug R&D programs. Become an expert in Tempus multimodal clinical and genomic data. Analyze and integrate large, diverse clinical and molecular datasets to extract insights and drive new research opportunities. Lead scientific and technical interactions with clients to co-architect solutions and projects. Become an expert in current and prospective clients' strategies, pipelines, and portfolios to identify where the Tempus platform can add value and collaborate with sales teams to realize that value. Collaborate with Research, Engineering & Data Science teams to develop and deliver innovative computational solutions. Drive continual improvement of the Tempus platform by communicating client feedback, staying ahead of research and industry trends, championing opportunities for new markets, and influencing our leadership and global account strategy teams. Work with Product and Engineering teams to streamline the workflow of computational analyses. Document, summarize, and communicate highly technical results and methods clearly to non-technical audiences. Author whitepapers and peer-reviewed manuscripts illustrating the value of multimodal analysis and AI in drug discovery. Qualifications Education to Masters or Ph.D. level combining quantitative and/or computational skills, e.g., Computational Biology, Biostatistics/Statistical Genetics, Bioinformatics, Biomedical Informatics, Biometrics, Data Science for Health, or similar. Biological or medical knowledge, e.g., Human Disease, Genetics/Genomics, Molecular Biology, or Immunology. Comfort in a client-facing role. Proficient in R or Python. Strong understanding of the molecular nature of human disease. Expert in delivering actionable insight from transcriptomic data sets. Experience with Clinical Trial Data and/or Real World Evidence. Experience with integrative methods to model multi-modal clinical and/or omics data. Experienced in SQL. Thrive in a fast‑paced environment and willing to shift priorities seamlessly. Experience in any of the following will also be beneficial: drug R&D oncology; immunology; single cell or spatial transcriptomics; mechanistic modeling and inference; knowledge and graph‑based AI techniques. CHI: $170,000-$230,000 NYC/SF: $180,000-$250,000 The expected salary range above is applicable if the role is performed from Massachusetts and may vary for other locations (California, Illinois, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. Massachusetts Applicants: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. #J-18808-Ljbffr

Our commitment to people with neuromuscular diseases Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more ************************* and follow us on X, LinkedIn and Facebook. Role Summary: The Principal S cientist , ADME-PK in Preclinical Development (PCD) department utilize s their knowledge in drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamic and bioanalytical principles to advance Dyne 's efforts surrounding delivery of therapeutic payloads to muscle and CNS tissues with the FORCE platform . This role is based in Waltham, MA. Primary Responsibilities Include: Design and execute internal/external preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of Dyne's drug candidates Represent PCD as the ADME-PK subject matter expert on discovery and program teams Partner with and support Research, Toxicology, Translational Biomarkers, Clinical, Regulatory, Project Management and other Dyne departments Collaborate with Clinical Pharmacology/Pharmacometrics to develop quantitative tools to translate PK/PD relationship from preclinical to clinical Author high quality Regulatory documents including INDs, CTAs, and NDA/BLA filings. Prepare strategic and science-based ADME strategies that meet regulatory requirements and program goals Facilitate strategic scientific communication via meetings, abstracts and manuscripts Education and Skill Requirements: PhD in Pharmacokinetics, Pharmacology, Pharmaceutics, Biomedical Sciences or other relevant field with >6 years (MS with >8 years, BS with >12 years) of experience in the biopharmaceutical industry, with evidence of drug development experience Strong knowledge of drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamics and bioanalytical principles F amiliarity with regulatory submission including FIH dosing strategy is highly desirable Proficient in using WinNonlin or other pharmacokinetic software Excellent communication (verbal and written) and presentation skills, as well as interpersonal skills and the ability to represent PCD in a team environment Experience with PK characterization of protein therapeutics or antibody-drug conjugates (ADCs) is desired #LI-Onsite MA Pay Range $159,000 - $195,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. #J-18808-Ljbffr