Research scientist jobs in Somerville, MA - 1,551 jobs

A global biotechnology company seeks an experienced Associate Principal Scientist to support in vitro pharmacology projects. The role involves collaborating with pharmacologists, managing CRO relationships, and assessing external resources for early drug discovery. The ideal candidate should possess a relevant Bachelor's degree and extensive industry experience. A hybrid work model is offered. Competitive salary range from $144,800 to $227,900 annually. #J-18808-Ljbffr

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A biotechnology company in Waltham, MA is seeking a Principal Scientist in ADME-PK to enhance drug delivery to muscle and CNS tissues. The successful candidate will design preclinical studies, author regulatory documents, and collaborate across various teams. Candidates should possess a PhD in a relevant field and over 6 years of industry experience, with expertise in pharmacokinetics and drug metabolism. This role offers a competitive salary in the range of $159,000 to $195,000 USD depending on experience. #J-18808-Ljbffr

Applied Physical Sciences (APS) is looking for a highly motivated Physical Scientist to join the Concord, MA team in a part-time, on-call (PTOC) position. Successful candidates will have a PhD in theoretical physics, expertise in inverse theory or tomography, and will support the development of state-of-the-art technologies for tomographic imaging with irregular experiment apertures, with a special emphasis on exploitation of high energy X-rays. APS works on exciting, technically challenging, cutting-edge technologies that will expose candidates to a wide variety of multidisciplinary fields, providing a stimulating environment with considerable opportunity for collegial interaction. At APS you will work in a small company environment where technical excellence is rewarded and an entrepreneurial spirit is encouraged, and you will have the chance to work directly with colleagues and customers that value innovation and creativity. Responsibilities Theoretical modeling of x-ray interaction physics, development of X-ray inversion paradigms for highly challenging experiment scenarios, rigorous characterization of the fundamental information limits of X-ray imaging. Software implementation of processing and modeling techniques, numerical execution of synthetic inversion experiments, display and quantification of model uncertainty Required Attributes and Skills PhD in theoretical physics, and expertise in modeling and inversion of X-ray data Subject matter expertise in one or more of the following: advanced numerical optimization, statistical methods, experiment design optimization, GPU-based computing Extensive experience with computational methods and programming for modeling physical phenomena and processing of real data e.g., Matlab, Python, PyTorch, or Fortran Exceptional communication skills (written and oral) for technical documentation and reviews with customers Desired Attributes and Skills Professional experience of 10+ years in DoD or related industry, a strong publication history in refereed technical journals, and a track record of successful performance on research programs under DARPA, IARPA, NAVSEA or ONR sponsorship is preferred. Experience as principal investigator working on advanced R&D programs Demonstrated technical leadership in modeling and simulation Expertise in one or more of the following: mathematical physics, model-based iterative methods for x-ray tomography, Monte Carlo radiative transport methods for Bremsstrahlung modeling, advanced numerical optimization techniques involving both continuous and discrete variables, regularization methods, uncertainty quantification using the Fisher Information Matrix and the Cramer-Rao Bound, and multi-objective optimization. Experience presenting talks at technical conferences APS, a wholly owned subsidiary of the General Dynamics Corporation, offers a small company environment including competitive salary, excellent benefits, and comfortable working conditions. This is a part-time on-call position open in the Concord, MA office. Candidates must possess or be able to obtain a Top Secret DOD security clearance. Qualified applicants are invited to submit a resume and application online at **************** fax them to ************, Attn: Human Resources, or mail to the company address. Please reference the requisition number and title of the position in the subject line of your submission. Equal Opportunity Employer/M/F/Disability/Protected Vet Invitation to Self-Identify In keeping with our commitment to Equal Employment Opportunity (EEO), Applied Physical Sciences invites all applicants to self-identify pre-offer as a protected veteran and/or an individual with a disability. Invitation to Self-Identify as Protected Veteran Online Form Invitation to Voluntary Self-Identification of Disability Online Form #J-18808-Ljbffr

Title:- Research Associate I Duration: Contract until Feb 2027 (Possible extension) Overview/Department Description We are seeking a contract upstream Research Associate to join our Cell Culture Platform group in Cell Culture Development department (CCD-CCP). CCD-CCP is a global business unit responsible for the development of cell culture platforms including media and bioprocess technologies for both fed-batch and perfusion from early and late-stage biologics projects, as well as all upstream CMC development activities for early phase projects (up to Phase II). The candidate will be self-motivated and strongly driven to succeed while demonstrating the ability to function well within a fast-paced and collaborative team-oriented environment. The candidate will also be inquisitive and innovative, exhibiting scientific curiosity and the ability to acquire new skills for fed-batch and perfusion based upstream cell culture processes. This is an exciting opportunity to learn cutting-edge cell culture techniques and develop cell culture subject matter expertise. This role will have significant impacts on early pipeline projects, next generation cell culture process development and manufacturing strategies within the global *** network. Main Duties & Responsibilities • Require to be on site daily; Weekend work required occasionally. • Plan and execute experiments to optimize upstream cell culture platform process at different scales (shake flasks, AMBR, 3L/10L bioreactors, etc.) • Perform upstream experiments and collaborate with other functional groups to speed Phase I pipeline projects • Contribute to technical reports, experimental protocols, and technical summaries for presentation internally and externally • Participate in the technology transfer of processes into manufacturing facilities • Ensure safety and environmental compliance are maintained in the workplace • Some weekend working may be required for this role Basic Qualifications • Bachelor or Master's degree in Chemical Engineering, Biochemical Engineering, Cell Biology, Biochemistry or a related discipline • Post-education experience ?=3 years • Understanding of aseptic technique and principles of mammalian cell culture • Detailed in lab operations and quick learner for new technologies Preferred Qualifications • Experience in the operation of fed-batch and/or perfusion-based cell culture bioreactors • Knowledge of CMC MINAKSHI SANGWAN Recruiting Lead - US Recruitment O ************ E *************************** W **********************

Immediate need for a talented Research Associate I. This is a 06+ Months Contract opportunity with long-term potential and is located in Framingham, MA (Onsite). Please review the job description below and contact me ASAP if you are interested. Job ID:26-01448 Pay Range: $34 - $44/hour. Employee benefits include, but are not limited to, health insurance (medical, dental, vision), 401(k) plan, and paid sick leave (depending on work location). Key Responsibilities: Require to be on site daily; Weekend work required occasionally. Plan and execute experiments to optimize upstream cell culture platform process at different scales (shake flasks, AMBR, 3L/10L bioreactors, etc.) Perform upstream experiments and collaborate with other functional groups to speed Phase I pipeline projects Contribute to technical reports, experimental protocols, and technical summaries for presentation internally and externally Participate in the technology transfer of processes into manufacturing facilities Ensure safety and environmental compliance are maintained in the workplace Some weekend working may be required for this role. Key Requirements and Technology Experience: Must have skills: - Understanding of aseptic technique and principles of mammalian cell culture, Cell culture platform process at different scales (shake flasks, AMBR, 3L/10L bioreactors, etc.) Bachelor or Master's degree in Chemical Engineering, Biochemical Engineering, Cell Biology, Biochemistry or a related discipline Post-education experience ?=3 years Understanding of aseptic technique and principles of mammalian cell culture Detailed in lab operations and quick learner for new technologies. Experience in the operation of fed-batch and/or perfusion-based cell culture bioreactors Knowledge of CMC Note- Weekend works is required and is occasionally. This is a rotating, schedule 1-4 hours on 1 weekend day and will include a Saturday or Sunday. This will be included in 40 work week and no to exceed 40 hours. Weekend work is pre-planned through end of year; new hire can swap with colleagues if available. Our client is a leading Pharmaceutical Industry, and we are currently interviewing to fill this and other similar contract positions. If you are interested in this position, please apply online for immediate consideration. Pyramid Consulting, Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. By applying to our jobs you agree to receive calls, AI-generated calls, text messages, or emails from Pyramid Consulting, Inc. and its affiliates, and contracted partners. Frequency varies for text messages. Message and data rates may apply. Carriers are not liable for delayed or undelivered messages. You can reply STOP to cancel and HELP for help. You can access our privacy policy here.

Discover Veranova: At Veranova, we believe people are our most important asset, and we are dedicated to building the most talented workforce in our industry. Our commitment to uncompromising focus on quality, compliance, safety, and excellence in delivery shapes everything we do. We are not just looking for skills; we are seeking innovative individuals who have a mindset open to learning and growth, and a desire to make a difference. Veranova is a global leader in the development and manufacturing of complex active pharmaceutical ingredients (APIs) for pharma and biotech customers. With deep technical expertise and impressive flexibility, we develop solutions and processes that support and accelerate innovation. Join us on our mission to enable current and next-generation therapeutics to improve and save the lives of patients. Role Overview: The Scientist role within the Chemical Development group will focus on the synthesis, process development, and analytical strategy for protected phosphoramidite precursors used in therapeutic oligonucleotide API manufacturing. This position is key to building Veranova's commercial capability in producing high-quality oligonucleotide building blocks. The ideal candidate will have strong expertise in phosphoramidite chemistry, including impurity profiling and customer-specific requirements. This role will also collaborate closely with the Analytical Team to establish robust characterization and control strategies that ensure exceptional product quality. Core Responsibilities: Develop and optimize synthetic routes for protected Phosphoramidite subunits used in therapeutic oligonucleotide API synthesis. Identify and mitigate side reactions commonly associated with Phosphoramidite chemistry. Define and implement specifications aligned with customer expectations for commercial-grade oligonucleotide precursors. Provide expert guidance to the Analytical Team on the selection and application of appropriate analytical methods for product and impurity characterization, based on prior experience and industry standards. Collaborate with cross-functional teams including Analytical Development, Quality, and Manufacturing to ensure successful scale-up and tech transfer. Prepare technical documentation including batch records, specifications, and development reports in accordance with SOPs and cGMP guidelines. Present scientific findings and project updates to internal stakeholders and external customers. Support the establishment of quality and regulatory standards for commercial production of oligonucleotide precursors. Contribute to project planning, budgeting, and timeline management for precursor development programs. Other duties as assigned . Qualifications: Required BS in Organic Chemistry or equivalent with 3-5 years related experience in a pharmaceutical industry, or MS in Organic Chemistry or equivalent with 0-2 years related experience in the pharmaceutical industry. Ability to read, analyze, and interpret English-language chemical periodicals, scientific journals, and regulatory documents. Experience with organic synthesis and process development Experience with common analytical techniques such as HPLC, GC, NMR, UV, and LC-MS. Experience in establishing integrated plans with defined resources and tasks. Ability to write clear and concise technical reports. Good understanding of Microsoft Office and statistical software. Demonstrate ability to exercise good judgment and make decisions quickly. Good written and verbal communication skills. Ability to work independently and in a team environment. Salary Range : $110,000 - $120,000 annual base salary Our Commitment: Health & Wellness: Comprehensive health & wellness benefits. Access to mental health resources and wellness programs. Generous PTO and holiday pay policies. Financial Wellness: Veranova is committed to fair and transparent compensation practices. This includes a competitive base salary, eligibility for performance-based bonuses, and an attractive 401(k) Plan with company match. Salary ranges reflect the scope and expectations of the role, and are based on market data, internal equity, and role-specific factors. Final compensation may vary depending on experience, skills, education, and business needs. Professional Development: Opportunities for continuous learning through LinkedIn Learning, workshops, conferences, and mentorship. Tuition Assistance for Undergraduate and Graduate degree programs. Inclusive Culture: At Veranova, an inclusive culture is integral to our values. We welcome people with diverse experiences and perspectives who share our mission to improve and save lives. Even if you don't meet every qualification, we encourage you to apply. Veterans, first responders, and those transitioning from military to civilian life bring valuable skills that strengthen our team. Additional Information: Applicants for this role must be authorized to work in the United States without further employer sponsorship. Agency and Search Firm Representatives: Veranova does not accept unsolicited resumes from agencies and/or search firms for this job posting. All your information will be kept confidential according to EEO guidelines. Veranova is an Equal Opportunity Employer. It is the policy of Veranova to provide equal employment access and opportunity to all persons regardless of age, race, color, national origin, religion, sex, sexual orientation, gender identity and/or expression, physical or mental disability, genetic information, citizenship, marital status, veteran status, or any other characteristic protected by federal, state, or local law. All applications are carefully considered, and your details will be stored on our secure Application Management System. This is used throughout Veranova for the selection of suitable candidates for our vacancies as they arise. Veranova respects your privacy and is committed to protecting your personal information. For more information about how your personal data is used please view our privacy notice .

Prepare injectable (parenteral) peptide and protein formulations to support in vivo and in vitro animal studies, including buffer, excipient, and surfactant selection Execute preclinical formulation development activities to support early research and screening programs Perform biophysical characterization and stability studies to assess formulation performance and robustness Support animal dosing studies by preparing, documenting, and delivering study-ready formulations Maintain accurate experimental records using ELN (Electronic Laboratory Notebook) and manage formulation requests/workflows Operate, maintain, and troubleshoot formulation, biophysical, and analytical laboratory instruments Analyze experimental data and contribute to scientific documentation and reporting Collaborate closely with cross-functional research teams to resolve formulation challenges and meet project timelines

A prestigious research institution in Boston is seeking an Associate in Biomedical Informatics to support biomedical research training and projects. The role involves developing knowledge graphs, conducting data analyses, and writing research reports under the guidance of experienced mentors. Applicants should have a Bachelor's degree in computer science and a keen interest in healthcare technologies. #J-18808-Ljbffr

Qualifications Bachelor's degree or higher in a relevant discipline with at least 3 years of applicable bioprocess experience. Experience with process purification of biomolecules (mAbs, vaccines, etc…) from harvest to drug substance Familiarly working in GxP cross matrix organizations Lab-scale purification process development and troubleshooting experience with standard downstream equipment (e.g. AKTAs, Repligen TFF, etc…) Direct hands on experience and knowledge of templated processes such as mAbs, pDNA, mRNA etc. Proficient expereine with data analysis tools such as Minitab, JMP, KNIME etc. Working knowledge of PAT applications development and implementation from bench scale to pilot (FlowVPE, IVI Raman etc…) Experience with HTS instrumentation for protein purification and process development. Working knowledge of GxP/ICH/Quality compliance systems of the biopharmaceutical industry Job Description We are looking for a Downstream Scientist to support our pharmaceutical client in Andover, MA. This person will lead, develop, and qualify purification techniques for biologics at both pilot and bench scale. This role involves hands-on execution of purification processes using a variety of unit operations including precipitation, depth filtration, tangential flow filtration (TFF), and chromatography. The scientist will support technology transfer, process troubleshooting, and continuous improvement initiatives. Key Responsibilities: Lead and execute purification processing using precipitation, depth filtration, TFF, and chromatography. Develop and characterize purification processes for monoclonal antibody (mAb) programs, including second-generation process development. Independently plan, design, and execute downstream experiments to support technology transfer of mAb programs. Operate and maintain downstream equipment such as AKTAs and Repligen TFF systems, and analytical tools including SoloVPE, Stunner, and Raman spectroscopy. Analyze data, prepare technical reports, and present findings to internal teams. Support manufacturing investigations and troubleshoot purification processes. Drive continuous improvement initiatives including 5S, TPM, and operational excellence. Plan and execute critical material production campaigns independently. Collaborate cross-functionally with project teams to ensure alignment and effective communication. - Familiarity with mRNA Lipid nano particle formulation and Final Drug Product (FDP) processes

A leading cancer research institute is seeking a Higher Scientific Officer specializing in assay development and compound profiling. The successful candidate will apply screening science to advance cancer drug projects, developing plate-based assays to identify small-molecule inhibitors. This position offers a dynamic research environment supported by state-of-the-art facilities, a collaborative team, and competitive compensation. Ideal candidates will have laboratory experience and an understanding of enzymology, along with skills in automation equipment. #J-18808-Ljbffr

Vaxess is developing a pipeline of next-generation therapeutics on our novel micro-array patch platform. With only five minutes of wear-time on the skin, the Vaxess' patch combines room temperature stability with simplified application to dramatically alter the way that drugs are delivered. Vaxess is committed to enabling products that are not only more effective, but also more accessible to patients around the world. The Role We are seeking a motivated and detail-oriented Research Associate with strong hands-on experience in chromatographic analysis to support QC release and stability testing. The successful candidate will perform routine cGMP QC testing using HPLC methods (RP-HPLC, SEC, IEX), Agilent HPLC systems, and additional supporting assays in a fast-paced, collaborative environment. This is a unique opportunity to be part of an emerging early-phase clinical company bringing innovative technology to the global market. Key Responsibilities Perform routine QC release and stability testing using HPLC methods including RP-HPLC, SEC, and IEX. Prepare samples, operate Agilent HPLC systems, verify system suitability, and ensure analyses meet method and specification requirements. Execute complementary analytical assays such as UV-Vis, pH, surface tension, and mechanical tests. Maintain complete, accurate documentation in compliance with cGMP, ALCOA+, and data integrity requirements. Conduct routine instrument care (solvent flushes, column care, daily checks) and assist troubleshooting under supervision. Process and review chromatographic data in Agilent OpenLab CDS. Support method qualification, validation, and transfer activities by executing protocols and recording observations. Maintain calibration, maintenance, and service records for analytical instrumentation. Independently author method SOPs, analytical protocols, technical reports, and contribute to regulatory submissions. Collaborate cross-functionally with QC, Analytical Development, Process Development, Manufacturing, and Regulatory teams to enable program success. Maintain rigorous laboratory documentation and complete, audit-ready analytical records. Thrive in a fast-paced, cross-functional environment with excellent communication and organizational skills. Qualifications Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or related field with 1-3 years of experience; or a master's degree with relevant laboratory experience. Hands-on experience operating HPLC systems; Agilent systems and OpenLab CDS experience strongly preferred. Practical experience with chromatographic techniques including RP-HPLC, SEC, and IEX. Experience supporting QC release or stability testing in a GMP/GLP environment. Strong attention to detail and ability to follow SOPs precisely. Excellent documentation practices and understanding of data integrity. Strong organizational skills with the ability to manage multiple workflows and prioritize effectively in a fast-paced environment. Excellent verbal and written communication skills and comfort working within interdisciplinary teams. Commitment to collaborative work within interdisciplinary project teams. At Vaxess, we're bringing together exceptional talent to drive our product development forward. We value collaboration, curiosity, and a dynamic work environment. To apply, please submit your CV/resume to ****************** .

UII America, Inc., a subsidiary company of Shanghai United Imaging Intelligence Healthcare Co. Ltd. (UII), is building an organization of highly-motivated, talented and skillful AI experts and software developers to strengthen our R&D power and address the need of our innovative products in the USA market. United Imaging Intelligence (UII) is committed to providing AI solutions for medical devices, imaging, and diagnosis - to helping clients better understand and embrace AI. United Imaging Intelligence is led by two world-renown leaders in the AI industry. Together, they will lead UII in focusing on “empowerment” and “win-win.” UII empowers doctors and equipment in order for doctors and hospitals to win, for research institutions to win, and for third-party companies to win. UII America, Inc. is building a world-class research and development team in Boston, MA. We are seeking Research Interns to contribute to our R&D efforts in Artificial Intelligence, Medical Imaging, and Computer Vision. As a part of our team, you will collaborate with senior experts, tackle challenging technical problems, and gain valuable experience developing AI solutions for healthcare. Exceptional work during the internship may lead to contributions to practical product solutions or publications in top-tier journals and conferences. Responsibilities: Conduct cutting-edge research on AI and Deep Learning algorithms to address challenges in medical imaging. Explore and develop medical image foundation models, multi-modality models, and generative AI techniques. Collaborate with senior team members to implement and refine advanced algorithms for medical imaging analysis and computer vision. Translate research findings into practical applications for real-world healthcare challenges. Contribute to team-oriented projects in a collaborative and innovative research environment. Stay updated on emerging trends and technologies in AI and medical imaging to drive impactful advancements. Qualifications: Currently pursuing an MS or PhD in Computer Science, Electrical Engineering, Biomedical Engineering, Statistics, Applied Mathematics, or a related field. A proven track record of publications in relevant fields (e.g., Machine Learning, AI, Computer Vision, Medical Imaging) is a plus. Knowledge of state-of-the-art AI methods including deep learning, generative AI, foundation models and multi-modality models. Familiarity with medical imaging analysis or computer vision. Proficiency in Python and C/C++. Hands-on experience with deep learning frameworks such as PyTorch or TensorFlow. Strong problem-solving abilities, critical thinking, and self-motivation. Effective communication skills and a collaborative mindset.

A consulting firm specializing in healthcare seeks a Senior Consultant in Boston, MA. The role involves managing research efforts, mentoring junior consultants, and providing strategic insights to clients. Candidates should have an advanced degree or relevant experience in life sciences consulting, strong data synthesis abilities, and excellent communication skills. The position offers a competitive salary starting at $128,000 plus bonus potential, making it an attractive opportunity for professionals in the biopharmaceutical industry. #J-18808-Ljbffr

A cancer research organization in Boston seeks a Principal Artificial Intelligence & Machine Learning Engineer I/Scientist I. This role involves collaborating with physician scientists and leading research efforts. The ideal candidate has a Master's degree, 8+ years of experience in AI/ML, and strong Python skills. The position requires problem-solving abilities, team collaboration, and experience in clinical or research environments. A commitment to diversity and inclusion is essential for this role. #J-18808-Ljbffr

Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. Responsibilities Partner with our pharma clients to design, develop and execute computational research leveraging the Tempus platform to advance drug R&D programs. Become an expert in Tempus multimodal clinical and genomic data. Analyze and integrate large, diverse clinical and molecular datasets to extract insights and drive new research opportunities. Lead scientific and technical interactions with clients to co-architect solutions and projects. Become an expert in current and prospective clients' strategies, pipelines, and portfolios to identify where the Tempus platform can add value and collaborate with sales teams to realize that value. Collaborate with Research, Engineering & Data Science teams to develop and deliver innovative computational solutions. Drive continual improvement of the Tempus platform by communicating client feedback, staying ahead of research and industry trends, championing opportunities for new markets, and influencing our leadership and global account strategy teams. Work with Product and Engineering teams to streamline the workflow of computational analyses. Document, summarize, and communicate highly technical results and methods clearly to non-technical audiences. Author whitepapers and peer-reviewed manuscripts illustrating the value of multimodal analysis and AI in drug discovery. Qualifications Education to Masters or Ph.D. level combining quantitative and/or computational skills, e.g., Computational Biology, Biostatistics/Statistical Genetics, Bioinformatics, Biomedical Informatics, Biometrics, Data Science for Health, or similar. Biological or medical knowledge, e.g., Human Disease, Genetics/Genomics, Molecular Biology, or Immunology. Comfort in a client-facing role. Proficient in R or Python. Strong understanding of the molecular nature of human disease. Expert in delivering actionable insight from transcriptomic data sets. Experience with Clinical Trial Data and/or Real World Evidence. Experience with integrative methods to model multi-modal clinical and/or omics data. Experienced in SQL. Thrive in a fast‑paced environment and willing to shift priorities seamlessly. Experience in any of the following will also be beneficial: drug R&D oncology; immunology; single cell or spatial transcriptomics; mechanistic modeling and inference; knowledge and graph‑based AI techniques. CHI: $170,000-$230,000 NYC/SF: $180,000-$250,000 The expected salary range above is applicable if the role is performed from Massachusetts and may vary for other locations (California, Illinois, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. Massachusetts Applicants: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. #J-18808-Ljbffr

Our commitment to people with neuromuscular diseases Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more ************************* and follow us on X, LinkedIn and Facebook. Role Summary: The Principal S cientist , ADME-PK in Preclinical Development (PCD) department utilize s their knowledge in drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamic and bioanalytical principles to advance Dyne 's efforts surrounding delivery of therapeutic payloads to muscle and CNS tissues with the FORCE platform . This role is based in Waltham, MA. Primary Responsibilities Include: Design and execute internal/external preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of Dyne's drug candidates Represent PCD as the ADME-PK subject matter expert on discovery and program teams Partner with and support Research, Toxicology, Translational Biomarkers, Clinical, Regulatory, Project Management and other Dyne departments Collaborate with Clinical Pharmacology/Pharmacometrics to develop quantitative tools to translate PK/PD relationship from preclinical to clinical Author high quality Regulatory documents including INDs, CTAs, and NDA/BLA filings. Prepare strategic and science-based ADME strategies that meet regulatory requirements and program goals Facilitate strategic scientific communication via meetings, abstracts and manuscripts Education and Skill Requirements: PhD in Pharmacokinetics, Pharmacology, Pharmaceutics, Biomedical Sciences or other relevant field with >6 years (MS with >8 years, BS with >12 years) of experience in the biopharmaceutical industry, with evidence of drug development experience Strong knowledge of drug metabolism, ADME concepts, pharmacokinetics, pharmacodynamics and bioanalytical principles F amiliarity with regulatory submission including FIH dosing strategy is highly desirable Proficient in using WinNonlin or other pharmacokinetic software Excellent communication (verbal and written) and presentation skills, as well as interpersonal skills and the ability to represent PCD in a team environment Experience with PK characterization of protein therapeutics or antibody-drug conjugates (ADCs) is desired #LI-Onsite MA Pay Range $159,000 - $195,000 USD The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. #J-18808-Ljbffr

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A leading cancer research institute in Boston is looking for a Principal Artificial Intelligence & Machine Learning Engineer/Scientist I. This role involves working on short-term and long-term projects that revolutionize cancer research using AI and machine learning. Candidates should possess a Master's degree, have 8+ years of experience in AI/ML, and be proficient in Python. The position offers a competitive salary range of $154,000 to $184,500 and invites applicants committed to innovative cancer care. #J-18808-Ljbffr