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Senior principal scientist salary

Quoted expert
Dr. Howard Whiteman

Average senior principal scientist salary

$119,042

$57.23 hourly rate

Entry-level senior principal scientist salary
$83,000 yearly salary
Updated January 8, 2025

Average Senior Principal Scientist Salary

The average salary for a Senior Principal Scientist in the United States is approximately $119,042 per year, translating to about $57 per hour. This role requires extensive experience and often commands higher salaries in specialized sectors.

Factors Influencing Salary

Several factors impact a Senior Principal Scientist's earnings:

  • Location: Salaries vary significantly by state. For instance, positions in California and Massachusetts tend to offer the highest compensation.
  • Experience: More experienced professionals typically earn more, with significant salary increases observed with each year of experience.
  • Industry: Industries such as pharmaceuticals and biotechnology generally provide higher salaries compared to academia or government roles.

As you consider your career trajectory, it's essential to evaluate these elements. Understanding the salary landscape can aid in making informed decisions, whether you are exploring new opportunities or negotiating your current position.

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Where can a Senior Principal Scientist earn more?

Compare salary by location
Vs
177k
157k
137k
117k
97k
77k
57k
Columbus, OH$149,653
Columbia, MO$86,575
Compare salary by company
Vs
171k
151k
131k
111k
91k
Amazon$156,827
Arcus Biosciences$121,293

Senior principal scientist salary estimates from across the web

Based on the latest salary information compiled by Zippia, Salary.com, Indeed and Glassdoor, the average salary for a senior principal scientist typically falls between $119,042 and $252,317.
zippia
$119,042yearly
glassdoor[1]
$252,317yearly
indeed[2]
$152,309yearly
Salary.com[3]
$174,481yearly

Average senior principal scientist salary by state

The highest-paying states for senior principal scientists are California, Tennessee, and Nevada. The lowest average senior principal scientist salary states are Wisconsin, Kansas, and Mississippi.

  • State view
  • County view
Average salary:

Highest paying states for senior principal scientists

RankStateAvg. salaryHourly rate
1New Jersey$127,253$61.18
2Montana$126,299$60.72
3Nevada$130,576$62.78
4Arizona$124,340$59.78
5Illinois$120,701$58.03
6Connecticut$120,770$58.06
7California$141,024$67.80
8Massachusetts$115,408$55.48
9Alaska$127,494$61.30
10Tennessee$140,653$67.62
11Washington$108,887$52.35
12Oregon$112,032$53.86
13Maine$120,359$57.86
14Indiana$121,701$58.51
15Delaware$110,190$52.98
16North Carolina$102,224$49.15
17Pennsylvania$103,794$49.90
18Vermont$100,431$48.28
19New York$103,251$49.64
20Maryland$101,684$48.89
21Florida$100,034$48.09
22Wyoming$94,212$45.29
23New Hampshire$93,134$44.78
24Minnesota$95,017$45.68
25New Mexico$92,837$44.63
26West Virginia$95,563$45.94
27Hawaii$104,544$50.26
28Virginia$93,574$44.99
29Colorado$94,193$45.29
30Ohio$93,935$45.16
31South Dakota$89,493$43.03
32Rhode Island$99,020$47.61
33Texas$93,267$44.84
34District of Columbia$107,247$51.56
35Arkansas$90,968$43.73
36Louisiana$94,257$45.32
37Idaho$86,052$41.37
38Utah$92,693$44.56
39Oklahoma$92,068$44.26
40Nebraska$86,365$41.52
41North Dakota$82,996$39.90
42Wisconsin$82,875$39.84
43Missouri$86,544$41.61
44Alabama$87,505$42.07
45Michigan$85,281$41.00
46Kansas$82,267$39.55
47Kentucky$83,864$40.32
48Georgia$77,877$37.44
49Mississippi$81,444$39.16
50South Carolina$74,891$36.01
51Iowa$66,910$32.17

Highest paying cities for senior principal scientists

The highest-paying cities for senior principal scientists are San Francisco, CA, Rahway, NJ, and Indianapolis, IN.

RankCityAvg. salaryHourly rate
1San Francisco, CA$149,653$71.95
2Rahway, NJ$127,346$61.22
3Indianapolis, IN$121,398$58.36
4Chicago, IL$121,037$58.19
5Ridgefield, CT$120,464$57.92
6Andover, MA$115,660$55.61
7Dover, DE$110,000$52.88
8Seattle, WA$109,769$52.77
9Washington, DC$107,314$51.59
10New York, NY$103,267$49.65
11Morrisville, NC$102,705$49.38
12Annapolis, MD$101,803$48.94
13Providence, RI$99,058$47.62
14Saint Paul, MN$95,052$45.70
15Baton Rouge, LA$94,536$45.45
16Boulder, CO$94,135$45.26
17Austin, TX$93,914$45.15
18Concord, NH$93,198$44.81
19Little Rock, AR$91,073$43.79
20Columbia, MO$86,575$41.62

Senior Principal Scientists are the most in-demand in these five cities:

  1. San Francisco, CA
  2. Indianapolis, IN
  3. Chicago, IL
  4. Seattle, WA
  5. Washington, DC

Senior principal scientist salary details

A senior principal scientist's salary ranges from $83,000 a year at the 10th percentile to $169,000 at the 90th percentile.

Average senior principal scientist salary graph
Average senior principal scientist salary graph, trends, and summary

What is a senior principal scientist's salary?

PercentileAnnual salaryMonthly salaryHourly rate
90th Percentile$169,000$14,083$81
75th Percentile$143,000$11,917$69
Average$119,042$9,920$57
25th Percentile$98,000$8,167$47
10th Percentile$83,000$6,917$40

Highest paying senior principal scientist jobs

The highest paying types of senior principal scientists are medical science liaison, senior scientist, and scientist.

Job titleAnnual salaryMonthly salaryHourly rateJob openings
Research Fellow$53,823$4,485$25.8859,746
Chemist$64,961$5,413$31.2320,221
Quality Control Analyst$59,217$4,935$28.4785,546
Quality Control Chemist$58,892$4,908$28.3190,467
Research Chemist$75,843$6,320$36.4653,769
Research And Development Chemist$77,233$6,436$37.13100,225

How would you rate the starting salaries for senior principal scientists, as well as the prospects for salary advancement?

Dr. Howard Whiteman

Professor of Biological Sciences, Director of the Watershed Studies Institute, Murray State University

Poor. Right now, people in these fields are not in it for the money; they do it because they have a passion for conservation, or science, or both. I do not see that changing shortly, but hope springs eternal.

Top companies hiring senior principal scientists now:

  1. Broadcom jobs (10)
  2. Invitae jobs (3)
  3. PepsiCo jobs (4)
  4. Amgen jobs (5)
  5. Bristol-Myers Squibb jobs (5)

Which companies pay senior principal scientists the most?

Senior principal scientist salaries at Amazon and Exelixis are the highest-paying according to our most recent salary estimates. In addition, the average senior principal scientist salary at companies like Riot Games and Genentech are highly competitive.

RankCompanyAverage salaryHourly rate
1Amazon$156,827$75.40
2Exelixis$150,343$72.28
3Riot Games$146,190$70.28
4Genentech$145,711$70.05
5Edwards Lifesciences$139,380$67.01
6Invitae$135,593$65.19
7Schrödinger Inc$134,669$64.74
8BNY Mellon$134,026$64.44
9Mars$133,768$64.31
10Nokia$131,142$63.05
11Amgen$127,507$61.30
12Bristol-Myers Squibb$124,892$60.04
13Novartis$124,871$60.03
14Xerox$124,655$59.93
15BlackBerry$124,437$59.83
16Eli Lilly and Company$124,213$59.72
17Rakuten Medical$122,405$58.85
18International Society for Pharmacoeconomics and Outcomes Research (ISPOR)$122,165$58.73
19Black Enterprise$122,082$58.69
20Arcus Biosciences$121,293$58.31

Wage gap by gender, race and education

$117,000$116,800$116,600$116,400$116,200$116,000
MaleFemale

Senior Principal Scientist salary by industry

The average senior principal scientist salary varies across industries:

  • The average senior principal scientist salary in the technology industry is $122,831, the highest of any industry.
  • The average senior principal scientist salary in the finance industry is $114,703.
  • Senior principal scientists in the non profits industry earn an average salary of $102,516, the lowest of any industry.

Highest paying industries for senior principal scientists

RankIndustryAverage salaryHourly rate
1Technology$122,831$59.05
2Pharmaceutical$114,703$55.15
3Manufacturing$106,461$51.18
4Health Care$106,179$51.05
5Non Profits$102,516$49.29

High paying senior principal scientist jobs

Senior principal scientist salary trends

The average senior principal scientist salary has risen by $20,008 over the last ten years. In 2014, the average senior principal scientist earned $99,034 annually, but today, they earn $119,042 a year. That works out to a 14% change in pay for senior principal scientists over the last decade.

Compare senior principal scientist salaries for cities or states with the national average over time.

Average senior principal scientist salary over time

Compare senior principal scientist salaries for individual cities or states with the national average.

Senior principal scientist salary by year

YearAvg. salaryHourly rate% Change
2025$119,000$57.23+3.0%
2024$116,000$55.53+4.5%
2023$110,000$53.04+3.2%
2022$107,000$51.34+1.9%
2021$105,000$50.36-2.1%

Recently added senior principal scientist salaries

CompanyJobLocationDate addedSalary
Bristol Myers SquibbSenior Principal Scientist, Development DmpkCambridge, MA06/28/2025$152,730
MerckSenior Principal Scientist, Downstream Biologics Process DevelopmentRahway, NJ06/28/2025$164,800
Johnson & JohnsonSenior Principal Scientist, Computational PathobiologistSpring House, PA06/27/2025$137,000
CalicoSenior/Principal Scientist, Medicinal ChemistrySouth San Francisco, CA06/27/2025$166,000
Gilead Sciences, Inc.Senior Principal Scientist, Attribute Sciences Biophysical Characterization, Analytical OperationsSanta Monica, CA06/26/2025$205,615
Johnson and JohnsonSenior Principal Scientist, Technology Innovation, Commercial Data ScienceDowne, NJ06/26/2025$137,000
California Life CompanySenior/Principal Scientist, Medicinal ChemistrySouth San Francisco, CA06/26/2025$166,000
Integral ConsultingSenior Consultant or Principal-Level Coastal Scientist/EngineerSan Francisco, CA06/26/2025$125,000
Kite Pharma, Inc.Senior Principal Scientist, Attribute Sciences Biophysical Characterization, Analytical OperationsSanta Monica, CA06/26/2025$205,615
GenentechSR Principal Scientist-Pathologist/Head of TS Digital Pathology AnalyticsSouth San Francisco, CA06/20/2025$198,900

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