Senior principal scientist jobs in California

Title: AI Research Scientist Responsibilities: Design, execute, and analyze machine learning experiments, establishing strong baselines and selecting appropriate evaluation metrics. Stay up to date with the latest AI research; identify, adapt, and validate novel techniques for company-specific use cases. Define rigorous evaluation protocols, including offline metrics, user studies, and adversarial (red team) testing to ensure statistical soundness. Specify data and annotation requirements; develop annotation guidelines and oversee quality control processes. Collaborate closely with domain experts, product managers, and engineering teams to refine problem statements and operational constraints. Develop reusable research assets such as datasets, modular code components, evaluation suites, and comprehensive documentation. Work alongside ML Engineers to optimize training and inference pipelines, ensuring seamless integration into production systems. Contribute to academic publications and represent the company in research communities, as needed. Educational Qualifications: Ph.D. in Computer Science, Artificial Intelligence, Machine Learning, or a related field is strongly preferred. Candidates with a master's degree and exceptional research or industry experience will also be considered. Industry Experience: 3-5 years of experience in AI/ML research roles, ideally in applied or product-focused environments. Demonstrated success in delivering research-driven solutions that have been deployed in production. Experience collaborating in cross-functional teams across research, engineering, and product. Publications in top-tier AI/ML conferences (e.g., NeurIPS, ICML, ACL, CVPR) are a plus. Technical Skills: Strong foundational knowledge in machine learning and deep learning algorithms. Hands-on experience with PEFT/LoRA, adapters, fine-tuning techniques, and RLHF/RLAIF (e.g., PPO, DPO, GRPO). Ability to read, implement, and adapt state-of-the-art research papers to real-world use cases. Proficiency in hypothesis-driven experimentation, ablation studies, and statistically sound evaluations. Advanced programming skills in Python (preferred), C++, or Java. Experience with deep learning frameworks such as PyTorch, Hugging Face, NumPy, etc. Strong mathematical foundations in probability, linear algebra, and calculus. Domain expertise in one or more areas: natural language processing (NLP), symbolic reasoning, speech processing, etc. Ability to translate research insights into roadmaps, technical specifications, and product improvements. AI Research Scientist | Machine Learning | Deep Learning | Natural Language Processing | LLM | Hybrid | San Jose, CA

We are seeking a PhD-level Clinical Scientist to support the Biologics License Application (BLA) submission for a Breakthrough Therapy-designated biologic targeting a neurodegenerative rare disease. This role will contribute to late-stage clinical development, supporting clinical data interpretation, regulatory documentation, and cross-functional collaboration as the program advances toward potential approval. Key Responsibilities Support late-stage clinical development and BLA submission activities Interpret and synthesize clinical efficacy, safety, and biomarker data in pediatric populations Author and review clinical sections of regulatory documents (Modules 2 and 5) Collaborate cross-functionally with Regulatory, Clinical Operations, Biostatistics, and Medical Affairs Support FDA interactions and regulatory meetings as needed Qualifications PhD in a life sciences discipline 5+ years of clinical development experience in biotech or pharma Experience supporting late-stage programs and regulatory submissions (BLA/NDA/MAA) Strong scientific writing and cross-functional collaboration skills Experience in rare disease, pediatric, neurodegenerative, or biologics programs preferred Why This Role This is an opportunity to contribute to a Breakthrough Therapy-designated biologic at a critical regulatory milestone, advancing a program aimed at addressing serious unmet need in pediatric neurodegenerative disease.

The Attribute Sciences Digital and Engineering (ASDE) group provides scientific and technical engineering expertise in support of pipeline and commercial portfolio. This team applies advanced data & computational analytics to advance products across all stages of therapeutic development. This position is part of the ASDE group and will support analytical assay templating and activity creation within Biovia electronic notebook system (ELN) for Attribute Science (AS) group within Process Development. Responsibilities will vary and include organizing and leading meetings with functional area teams to gather template, activity, and parser requirements. Once requirements are gathered the role will author, revise, and deploy assay templates and activities. Additional responsibility of the role will be implementing jobs aids, user support, and troubleshooting/revision post-release. Position Responsibilities: • Interface with scientists across AS organization to understand requirements for assay workflows. • Develop and maintain Biovia ELN assay templates and activities • Troubleshoot issues in collaboration with scientists, ELN Support team and Biovia. • Provide training and job aid documentation for scientists. Basic Qualifications • Master's degree OR • Bachelor's degree and 2 years of scientific or engineering experience OR • Associate's degree and 6 years of scientific or engineering experience OR • High school diploma / GED and 8 years of scientific or engineering experience Preferred Qualifications • Experience with execution of lab instrument assays • Experience with Biovia or other ELN software platforms • Proficiency with Excel for spreadsheet section in templates • Ensure FAIR data practices are followed when creating templates • Strong communication skills • Ability to deliver high quality results in a timely manner • Proactive in seeking feedback and engagement with teams • Strong attention to detail • Demonstrated ability to work under minimal direction • Ability to adapt to changing business needs • Ability to multi-task and function in a dynamic environment REMOTE ROLE

We are looking for a Research Scientist - Bioinformatics II for a very important client. Job Responsibilities: The primary responsibility of a Research Scientist in a Pharmacokinetics Analyst role is to add to and enhance the ability of the drug metabolism and pharmacokinetics department to support discovery and development project teams. The specific responsibilities are as follows. Knowledge, Experience and Skills: Essential Functions: • Prepare biological samples (plasma, tissues, and cells) for analysis. • Analyze samples using liquid chromatography and mass spectrometry (LC-MS). • Develop/review analytical methods and troubleshoot as needed. • Consistently recognize anomalous and inconsistent results and interpret experimental outcomes. • Process, record, and manage experimental data. • Summarize results in memo, report, and/or slide formats. • Participate in group meetings, present results, and interpret data. • Understand and follow standard operating protocols and laboratory requirements to conduct work safely. • Prepare/review data reports for regulatory filings. The ideal candidate will possess the following qualities. • Collaborative and able to work in a team oriented, dynamic, and innovative environment. • Strong motivation, attention to detail, and ability to think independently. • 1-2 years of experience with a PhD degree in Chemistry, Pharmacokinetics, or other relevant life science disciplines. • Experience with liquid chromatography and mass spectrometry is required. • Ability to troubleshoot and optimize bioanalytical assays as needed. • Ability to perform pharmacokinetic analysis is desirable. • Must be able to work effectively on multiple programs as well as have the flexibility to shift priorities while working in a fast-paced environment. • Strong written and verbal communication skills • Computer skills including MS Office, GraphPad Prism, Watson LIMS, and Phoenix Winnonlin are desirable. Required Years of Experience: 1-2 Years of Experience Top 3 Required Skill Sets: Liquid chromatography, mass spectrometry, and bioanalysis. Top 3 Nice to Have Skill Sets: Pharmacokinetics, non-compartmental analysis, and animal operation. Unique Selling Point of this role: an interdisciplinary position with great learning and growing opportunities.

Shift: Tuesday through Saturday, 8:00 AM - 4:30 PM Are you ready to work making the world a safer, healthier place? Join our mission to continuously move science forward; to innovate and advance all aspects of our business to improve the health and safety of our communities and lives. Scientist 1 Compensation: $20.00 per hour Make an impact. Build a career. At Pace , everything we do is built upon an unwavering commitment to making the world a safer, healthier place. We continually work to develop innovative practices that drive sustainability and empower our partners with accurate, quality data at every critical moment and milestone. That's why we need you your curiosity, your talents, and your drive to help us advance this important work, and your career. Find your place at Pace Join us as a Scientist I, where you'll put your love of science to work performing and overseeing projects within the wet chemistry department of our environmental testing laboratory. What you'll do Facilitate and support the analysis, administration and oversight of air, water and soil samples using standard chemistry/ biochemistry policies, programs, and practices Clean, maintain and calibrate instruments Maintain detailed and organized documentation on all laboratory work What you'll bring Bachelor's degree in Chemistry/ Biochemistry or a closely related field, or an equivalent combination of education, training and experience Ability to perform work in a lab or office setting, remain standing for long periods while conducting tests, work around strong smells, and wear personal protective equipment while handling samples (e.g., lab coat, safety glasses and gloves; all PPE provided by Pace ). What we promise Comprehensive benefit program, including medical, vision and dental insurance, 401(k) matching and tuition reimbursement Opportunities to build a rewarding career An inclusive culture that stands for integrity, innovation and growth Find Your Place at Pace - We need you - your curiosity, your talents, and your drive - to help us advance this important work. Benefits When you join Pace , you commit to work that makes a positive impact on our communities and our world. We commit to supporting you with benefits and perks that make a positive impact on your life. Full-time roles are eligible for our comprehensive benefits program which includes competitive salaries, medical, dental vision, 401K retirement savings plan (100% vested immediately in the employer match), life, disability and voluntary benefits, paid time off for holiday, sick and vacation days, HSA, wellness program, flexible spending accounts, tuition reimbursement, Employee Assistance program, parental leave, optional legal coverage and ID theft. Equal Opportunity Employer Pace provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, creed, color, religion, genetics, protected veteran status, national origin, sex, age, disability, marital status, sexual orientation, gender identity or expression, citizenship, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Neomorph is seeking a highly experienced and strategically minded Associate Principal Scientist or Principal Scientist in Computational Chemistry to join our dynamic and collaborative discovery team. This is a hands-on, individual contributor role - you will lead cutting-edge computational chemistry efforts, roll up your sleeves to generate design hypotheses and deliver actionable insights, while influencing program strategy and scientific direction. Whether you join as an Associate Principal or Principal level depends on your years of experience and track record. In either case, you will play a key role in advancing our discovery pipeline from target assessment through candidate nomination, partnering with medicinal chemistry, structural biology, biophysics, and biology teams. Key Responsibilities * Serve as the primary computational chemistry contributor on one or more drug discovery programs - designing, executing and interpreting computational workflows to support hit identification, hit-to-lead, and lead optimization. * Integrate structure- and ligand-based design, cheminformatics, predictive modeling and molecular simulation to propose novel compounds and drive progression of small-molecule therapeutics (including molecular glues/degraders). * Translate SAR, structural and modeling data into innovative design hypotheses; prioritize compounds and support decision-making alongside drug discovery teams. * Collaborate cross-functionally with medicinal chemistry, structural biology, biophysics, and biology to impact program strategy, compound design and project milestones. * Develop, optimize and deploy computational tools, workflows and methods (e.g., docking, MD, free energy calculations, ML/AI-driven design) to enhance our internal capabilities and accelerate discovery. * Present scientific results and strategic recommendations to internal project teams and senior leadership; provide mentorship and scientific guidance to less-experienced colleagues (without direct line-management responsibility). * Stay abreast of emerging computational chemistry technologies, apply deep domain knowledge and help shape the future of our computational capability. * Required Qualifications Associate Principal Scientist level: * PhD in Computational Chemistry, Theoretical Chemistry, or a related field with 6+ years, MS with 9+ years, or BS with 12+ years of relevant industry experience in drug discovery. Principal Scientist level: * Ph.D. in Computational Chemistry, Theoretical Chemistry, Chemistry or related field with 8+ years, M.S. with 11+ years or B.S. with 14+ years of relevant industry experience. For both levels: * Demonstrated hands-on experience in small-molecule drug discovery, with proven ability to apply molecular modeling, docking, free energy calculations, QSAR/ML, and cheminformatics to support compound design and progression. * Strong record of working independently and delivering high-quality scientific work, while also collaborating effectively in cross-functional teams. * Proficiency with commercial and/or open source computational chemistry and molecular modeling software (e.g., Schrödinger, OpenEye, AMBER, GROMACS, etc.), and fluency in scripting/programming (e.g., Python, R). * Excellent communication and collaboration skills, with ability to influence project teams and senior leadership through scientific insight. * Self-starter attitude, willing to roll up sleeves and execute hands-on work while contributing strategically. * Please note: This role is not a people-manager/line-management position - it is a senior individual contributor role, intended for a strong computational scientist who thrives doing the work directly and influencing through scientific leadership rather than managerial oversight. Base salary range for Associate Principal Scientist is $176,000 ‒ $198,000 Base salary range for the Principal Scientist is: $187,000 - $240,000 Why Neomorph? At Neomorph, we believe scientific excellence thrives in an environment rooted in transparency, integrity, inclusivity, passion and flexibility. You'll join a growing team at the forefront of targeted protein degradation, where your contributions as an individual contributor will have significant impact on the company's discovery trajectory. What we offer: * Industry competitive compensation * Annual target bonus * Stock options * 401K plan * Career advancement opportunities * Monthly town halls to share business and scientific updates Work Hard, Stay Well * Comprehensive medical, dental, and vision plans for employees and their dependents * Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution * Employee Assistance Program * 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave. * Supplemental pay for Pregnancy Disability Leave * Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care Lifestyle * Casual work environment * Volunteer days off each year to spend time contributing to causes you care about * Flexible work schedule * Access to onsite gym * Onsite space to store your bicycle (or surfboard) Have Fun! We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day). About Us: Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against 'undruggable targets'. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. Neomorph is headquartered in San Diego, California. Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law. Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

Job DescriptionBenefits: 401(k) 401(k) matching Bonus based on performance Dental insurance Free food & snacks Health insurance Paid time off Parental leave Vision insurance Position Summary: Crystal Bio Solutions is a CRO providing global-standard services in GLP/GCLP bioanalysis and biomarker. Our clients include multinational pharmaceutical companies and biotech companies. The Bioanalysis & Biomarkers Department specializes in Method Development, Method Validation, GLP/GCLP Bioanalysis for PK, and biomarkers. The team has successfully supported non-GLP, GLP (non-clinical) and GCLP (clinical) projects. The role is responsible for providing bioanalytical support for both pre-clinical and clinical projects and partnering with our clients for project success. Key Responsibilities: Independently propose assay design and/or strategy, develop, validate, conduct, and troubleshoot LCMS-based bioanalytical methods for the quantification of small molecule (and its metabolites) and biologics (e.g. ADC, mAB, protein, peptide, oligonucleotide etc) in support of PK, and Biomarker measurement Conduct or oversee GLP/GCLP sample analysis and data reporting. Present and interpret data internally and/or externally as needed. Serve as the Principal Investigator responsible for interaction with the client from the study design to scheduling, conducting, reporting, and transferring data. Ensure responsiveness to the client, timely delivery, and overall customer satisfaction. Serve as Subject Matter Expert (SME) for LCMS platform Ensure GLP/GCLP compliance, including accurate documentation and adherence to established procedures Author and/or review key regulatory documents, validation plans and reports, laboratory data, and technical reports. Provide technical leadership for LC-MS as a Subject Matter Expert, and mentor junior scientists. Assist in improving policies, procedures, work instructions and SOPs Understand and adhere to corporate standards regarding code of conduct, Environment Health & Safety (EHS), and GLP/GCP/GDP compliance. Perform other related duties as assigned Qualifications & Educational Requirements: Ph.D., M.Sc., M.A., B.A., in Biology, Immunology, Chemistry, Pharmacology, or other related scientific fields required, including a minimum of 4+(Ph.D.), 9+(Masters) or 12+(Bachelors) years of CRO/Pharma/Biotech experience. Hands-on experience and strong knowledge of GLP/GCLP bioanalysis. Experienced with GLP/GCLP LCMS method development and validation for PK and/or biomarker analysis. Functional experience utilizing LIMS and QMS systems for GLP/GCLP bioanalysis Established record of independent achievement of objectives and timelines while maintaining high work quality. Effective in team environments co-workers, managers, and clients Must be goal-oriented, compliance-ensured, quality-conscientious, and client-focused. Effective writing and communication skills are required. Experience in large molecule LCMS analysis (e.g. ADC, mAB, protein, peptide, oligonucleotide etc) preferred. Familiarity with additional bioanalytical platforms (e.g. LBA, PCR, Flow Cytometry) preferred. Supervisory experience in both project and talent (people) management is preferred. Pay Transparency Statement Title and compensation will be based on experience ( Senior Scientist / Associate Principal Scientist). At CP, your base pay is only part of your overall total compensation package. At the time of this posting, this role typically pays an annual base salary between $110,000 and $160,000 per year. The range displayed reflects the minimum and maximum target for new hires. Actual pay may be more or less than the posted range. Factors that influence pay include the individual's skills, qualifications, education, experience, and the position level and location. Agency Notice Direct Applicants OnlyWe are currently handling this recruitment directly and are not engaging with external recruiters or staffing vendors for this position. Thank you for your understanding.

Karius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us? Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position Summary You are highly curious and creative and desire to continuously grow and improve in your goal to make an impact on patients. You will be a key member of the Assay Development Analytics (ADA) team that helps drive the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. You will participate in experimental design, conduct thoughtful computational analyses by determining the analysis plan and executing it using the necessary tools and methodologies. You will work closely with colleagues in Molecular Biology to understand and deliver on our shared goals. You are a self-starter and always like to find ways to make things better. Reports to: Sr. Manager, Bioinformatics Location: Redwood City, CA or hybrid or remote Primary Responsibilities * Individual contributor to Assay Development Analytics (ADA), which drives the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. * Participate in experimental design, conduct computational analyses, understand rationale, set the analysis plan, and execute using the necessary tools and methodologies to deliver innovative assays. * Work closely with colleagues across the Molecular Biology and Laboratory Operations teams to understand the properties of the assays and ways to improve our technologies. * Continue to grow and learn in the necessary mathematical, technological, and software aspects of the field through internal knowledge acquisition and staying current with the latest relevant literature. * Open to exploring multiple approaches for problem-solving and modeling including borrowing across a wide range of quantitative disciplines. * Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings. * Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders. * Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature. * Share a passion for ensuring the quality of our statistical analysis, via reliability, reproducibility, and rigor. What's Fun About the Job? Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical Requirements Subject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements * Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience. * Publications demonstrating innovative investigation and interpretation of biological data. * Proven proficiency, and understanding of, modern statistics and machine learning. * Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise. * Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams. * Self-starter with the ability to independently drive results and influence project direction. * Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions. * Familiarity with a range of relevant laboratory techniques (either through hands-on work or from collaborations with laboratory-focused colleagues). * Familiarity and experience with bioinformatics tools, approaches, and workflows, particularly those related to next-generation sequencing data analysis. * Familiarity with design of experiments (DOE) approaches to optimize process settings. Personal Qualifications * Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning. * Excellence at communication and collaboration within a cross-functional team. * Detail oriented with exceptional organizational and time management skills. * Self-starting mentality and ability to drive results. * Comfortable working in an environment which combines both research aspects as well as development. * Ability to work effectively and efficiently in a fast-paced (startup) environment. Disclaimer The above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity Employer At Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at [email protected] and we will accommodate qualified individuals with disabilities. $142,231 - $213,347 a year

Job Description About us: Valent U.S.A. LLC, a wholly owned subsidiary of Sumitomo Chemical Company, Limited, engages in the development, registration, sales, and marketing of integrated technological solutions for crop production and pest management that deliver value for our customers and stakeholders. A leading crop protection firm serving the agricultural and non-crop products markets in North America, Valent products help growers produce safe and abundant food and fiber crops, and horticultural professionals improve the quality of life for their customers. The corporate motto, Products That Work, From People Who Care , describes the company's business philosophy. Valent seeks out and provides customers with innovative and effective solutions to their production challenges. Our vision is to be the best company delivering integrated solutions of biorational and traditional crop protection solutions to our customers. Valent is dedicated to creating a world that is healthier and more comfortable, and that has a sustainable abundance of quality, affordable food, helping crops to be the ultimate renewable resource. General Description: The purpose of this position is to conduct research and development efforts for Herbicide product development from conceptual phase through commercial production by working in coordination with the Senior Manager of Formulation Development and Analytical. The position is responsible to execute all related scientific research and/or development studies assigned for critical product development by individual effort or in collaboration with staff. Investigates the feasibility of applying a wide variety of scientific principles and concepts to potential inventions, products and problems. Plan and executes lab research. Maintain broad knowledge of state-of-the-art principles and theories. Make major contributions to scientific literature and conferences. Serve as in-house and outside consultant. May act as spokesperson on corporate research and development and advise top management. Participate in development of patent applications. Participate in promoting the professional development of junior research staff. Interfaces with various associated departments. Uses professional concepts to contribute to the development of company concepts and principles to achieve objectives in creative and effective ways. Principal Responsibilities: Use expert knowledge to independently plan, execute, and/or direct complex research and development projects for new or improved/innovative formulations and formulation technology, particularly in herbicide product segment. Manage formulation development activities through all stages of the project: development of preliminary formulations for efficacy testing, formulation optimization and processing studies to establish formulation for regulatory studies and EPA registration, scale-up, and commercial production. Exercise wide latitude in determining objectives and approaches, selecting methods, techniques and evaluation criteria for obtaining results. Requires coordination and communication with other Valent teams, including, Product Development Managers, Regulatory Project Managers, Toxicology Manager, Supply Chain, and production facility personnel. Provide technical support services to Manufacturing, Product Development Managers, Marketing, and Sales to solve technical problems or customer complaints related to Valent formulations. Work directly and independently with Market/Product Managers, Technology Managers and Product Development specialists to investigate feasibility for exploratory projects and to set objectives and maintain timelines for development projects for new or improved/innovative formulations and formulation technology. Serve as a resource and source for ideas for product innovation. Interact with Sumitomo Group Companies' formulation chemists, consultants, and industry personnel regarding research, development, and alternative technologies for formulation improvements. Evaluate formulation technology advances for application to Valent products and lead implementation efforts across product line. Viewed as an expert in all aspects of formulation research and development. Communicate proactively and effectively, both orally and in writing, with Senior Formulation Manager, Technology staff, personnel in other functional areas, and with appropriate external personnel, to ensure that projects are progressing on track and meet objectives and timelines: provide information on formulation project status and results; set priorities; resolve problems or issues; coordinate activities; and obtain feedback and needed information or assistance. Serve as consultant to management and as an external spokesperson for the company. Advise on direction for strategic planning from technical perspective to meet company objectives. May serve on industry committees or task forces. Engage Associate/Formulations Scientists in conduct of tasks/projects; train and develop; communicate priorities and objectives when collaborating; review work from subordinates. Serve as a resource/trainer/mentor for junior members of the group. Follow safety and regulatory plans, and waste disposal procedures. Participate in all required safety meetings and training programs. Perform research and/or development in collaboration with others for projects. Make detailed observations, analyze data and interpret results. Exercise technical discretion in the design, execution and interpretation of experiments that contribute to project strategies. Prepare technical reports, summaries, protocols, and quantitative analyses. Maintain familiarity with current scientific literature. Contribute to project process within his/her scientific discipline. Investigate, create and develop new methods and technologies for project advancement. Maintain high level of professional expertise through familiarity with scientific literature. May participate in scientific conferences and contribute to scientific journals. May be responsible for identifying patentable inventions. Use professional concepts in accordance with company objectives to solve complex problems in creative and effective ways. Manage all formulation development activities for assigned products. This includes constant interfacing with the other members of the Seed Treatment, Fungicide, Insecticide and Herbicide Teams in both Field Development and Marketing. Maintain expertise in all aspects of technology including requirements for various formulations, application methods, and test methods. Utilize knowledge and expertise to develop formulations that can be registered, commercialized, and meet customer needs and expectations. Serve as formulation technology expert in meetings with various companies, customers, and prospective or established business partners. Qualifications: MS, PhD, JD or equivalent, with 8+ years of related experience. Chemistry, related science degree. Experience in spreadsheets and word processing, problem solving, communication, detail oriented, evaluation and interpretation of data, instrument/equipment operation, maintenance and repair. In-depth knowledge of chemistry lab procedures, formulation development, manufacturing and packaging of agricultural chemicals and EPA approved inerts. Techniques for preparation and evaluation of formulations. More than 8 years of experience in preparation and evaluation of agricultural chemical formulations. More than 6 years experience in managing laboratory formulation research projects and technical support in the agricultural chemical industry. Demonstrated creativity, championing skills and deep technical knowledge of herbicide formulations and performance/stability requirements. Physical Demands and Work Environment (LAB Position) The physical demands and work environment characteristics described below are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Physical Demands include constant sitting, walking, standing, bending at the neck and waist, squatting, climbing, kneeling, crawling, twisting at the neck and waist, simple grasping, power grasping, and fine manipulation with hands, pushing and pulling with hands, reaching above shoulder level, and lifting and carrying up to 25 lbs.; and occasional lifting and carrying of up to 50 lbs. Will require the employee to lift and carry up to a 2.5-gallon jug containing liquid formulations and products. May be required to work in powder room environment to test or develop dry formulation products. This includes milling activities for solid formulations (granular and powder) in a dusty environment that will require the use of respirator and other personal protective equipment. Work Environment includes exposure to or working in or around moving cars, trucks, forklifts, equipment and machinery including a computer keyboard and mouse; uneven ground; excessive noise; extremes in temperature, humidity, or wetness; dust, gas, fumes, or chemicals; heights; operation of foot controls or repetitive foot movement. May be required to wear a respirator and other personnel protective equipment (including special visual or auditory equipment). May require occasional travel. Requires on-site laboratory base of operation. Frequency Definitions: Constant = Over 40% / Frequent = Up to 40% / Occasional = Up to 10% What We Offer We recognize that compensation and benefits play a crucial role in your career decisions. That's why we're dedicated to equitable pay practices and transparency in how we reward our employees. Base Salary: The estimated annual base salary for this position ranges from: $100,000 to $145,000 . Individual pay is based upon location, skills, experience, and other relevant factors. Incentives: All full-time employees are eligible for an incentive program or profit-sharing program in addition to their base salary. Benefits: High-quality healthcare coverage starting on day one, with options for medical (HSA/HRA), vision, and dental plans 5% company contribution to your 401(k), plus a quarterly discretionary bonus Immediate 100% vesting of all retirement contributions Financial assistance programs to support your goals Life and disability insurance for added security Generous paid time off, including vacation, holidays, and volunteer days Our Commitment to a Sustainable Future At Valent Group of Companies, we're proud to power a sustainable future through our work. Sustainability and corporate social responsibility (CSR) have been at the core of our culture since the beginning. Today, they continue to drive everything we do. Join us in making a meaningful impact and contributing to a better world. Valent U.S.A., Valent North America LLC, Valent BioSciences LLC and Mycorrhizal Applications LLC are an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation and/or identity, national origin, citizenship, immigration status, disabilities, or protected veteran status. #LI-ONSITE

Ready to redefine what's possible in molecular diagnostics? Join a team of brilliant, passionate innovators who wake up every day determined to transform healthcare. At BillionToOne, we've built something extraordinary-a culture where transparency fuels trust, collaboration drives breakthroughs, and every voice matters in our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we strive to build products that are 10x better than anything that exists today. Our people are our greatest asset: talented scientists, engineers, sales professionals, and visionaries united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion-every innovation you contribute helps remove fear of unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help build the future of precision medicine, this is where you belong. We are looking for a Senior Bioinformatics Scientist to join a fast growing team. This person will be responsible for the generation, analysis, and communication of clinical next-generation DNA sequencing data for the Northstar oncology products. Our sample volume is growing extremely quickly, and this role will own the further development of our analysis pipeline to analyze tens of thousands of samples, and be the lead scientist for everything related to our bioinformatics analyses. The Senior Bioinformatics Scientist role is a full-time onsite position and reports to the Senior Manager of Bioinformatics, Oncology. Responsibilities: Develop sophisticated and robust NGS analysis pipelines capable of processing tens of thousands of samples Develop tests and test frameworks for NGS pipelines Analyze and troubleshoot clinical NGS data Analyze assay performance and contribute to publications that demonstrate the clinical validity and utility of our tests Design new quality metrics and processes for clinical molecular diagnostic assays Collaborate with R&D scientists to generate new scientific insights Communicate assay performance and capabilities to clinical personnel at weekly meetings and to other non-clinical stakeholders Qualifications: PhD in Bioinformatics, Computational Biology, Computer Science, Bioengineering, Physics or related fields 2+ years of experience developing robust and scalable bioinformatics pipelines 2+ years of experience analyzing NGS data Fluency in Python Experience with Linux environment, GitHub and AWS Excellent communication and presentation skills, ability to work across functional teams and with non-experts Nice-To-Haves: Start-up experience Experience working in a regulated environment Experience with CI/CD pipelines and dockerized code deployment Experience with cloud infrastructure management with infrastructure as code such as CDK Benefits And Perks: Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients Open, transparent culture that includes weekly Town Hall meetings The ability to indirectly or directly change the lives of hundreds of thousands patients Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80% Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%) Supplemental fertility benefits coverage Retirement savings program including a 4% Company match Increase paid time off with increased tenure Latest and greatest hardware (laptop, lab equipment, facilities) Free daily on-site lunches provided from top eateries A variety of perks on campus (state of the art gym, restaurant) Free on-site EV charging (compatible with all EVs, including Tesla) At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.). For this position, we offer a total compensation package of $244,805 per year, including a base pay range of $156,060 - $176,868 per year. BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. For more information about how we protect your information, we encourage you to review our Privacy Policy. About BillionToOne BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA-a breakthrough that's already transformed the lives of over half a million patients worldwide. Our Impact: We've pioneered game-changing diagnostic solutions that are redefining industry standards. Unity Complete™ stands as the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. In oncology, our Northstar liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care. Our Growth: From $0 to $125 million in Annual Recurring Revenue in just four years. We've raised close to $400 million in funding, including a $130 million Series D round in June 2024, achieving a valuation of over $1 billion. This backing comes from world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest. Our Recognition: Forbes recently named us one of America's Best Startup Employers for 2025, and we were awarded Great Place to Work certification in 2024-with an incredible 100% of our people reporting they are willing to give extra to get the job done. These honors recognize not just our innovation but the exceptional culture we've cultivated-one that remains authentically collaborative and transparent even as we've scaled. Our Future: Headquartered in Menlo Park with facilities in Union City, California, we're continuing to push the boundaries of what's possible in molecular diagnostics. Recent clinical outcomes data for Unity Fetal Risk Screen and new advances in cancer diagnostics prove we're just getting started. At BillionToOne, you'll join a diverse team of passionate innovators who believe that the best science happens when brilliant minds collaborate openly, think boldly, and never lose sight of the patients whose lives depend on our work. Ready to help us change the world, one diagnosis at a time? Learn more at ********************

Practice/Department: Habitat Restoration Internal Title: As-Needed Coastal Scientist Work Environment: Hybrid Compensation: $30-$40 hourly* Dudek's journey began in 1980 with a vision to serve Southern California's water and wastewater agencies. Today, we are a 100% employee-owned firm supporting clients nationwide and delivering projects that improve and protect the built and natural environments of communities throughout the United States. Our work has been recognized by leading industry organizations, and we've been honored with multiple national Top Workplace Awards. Our employees are unified by a singular commitment to supporting projects that address key societal issues, such as the transition to renewable energy, infrastructure hardening and repair, environmental protection, and community resilience. Learn more about our award-winning culture, the benefits and perks of being a Dudekian, and the projects you will have the opportunity to shape.Who You AreAs an employee you embrace accountability, working safely, and collaboration while thinking resourcefully and independently. Like all Dudekians, you are curious and solution-oriented, with the ability to adapt quickly to changes and approach challenges with a spirit of innovation.How You'll Make an ImpactWe are currently seeking a self-motivated individual with proven experience in coastal science to join our Habitat Restoration Team. This position will have professional growth and career advancement opportunities as well as expanded responsibilities consistent with the recipient's skills and motivations. This is a variable-hour role.Duties and Responsibilities Support the planning and design of a wide range of coastal projects, including ecosystem restoration, coastal flood and erosion management, and sea level rise adaptation planning. Provide quality work products ensuring high standards in design and documentation. Collaborate with multidisciplinary teams-geotechnical, structural, hydraulic engineers, landscape architects, biologists, and more-to advance integrated, nature-based solutions from concept through construction. Thrive in a fast-paced consulting environment managing multiple priorities and deadlines independently or as part of a team. Prepare written technical reports including site assessments and monitoring reports for coastal projects. Perform observations of project implementation/construction and prepare punch list field reports for projects. Minimum Qualifications B.A. or B.S. in Environmental Science, Earth System Science, Biology, Coastal Engineering, or other applicable environmental field with strong coastal background. 2+ years of professional experience in coastal science and habitat restoration Excellent verbal and written communication skills and ability to draft and edit technical documents. Able to conduct strenuous field work in hot weather (over 100 F) and in steep terrain conditions. Work may involve assignments in remote locations with overnight stays and working individually. License to legally operate a motor vehicle in the State of California. Must possess a valid driver's license and have active personal automobile liability insurance by first day of employment Preferred Qualifications Ability to support the development of new projects and/or lead business development efforts in collaboration with the Habitat Restoration Practice Director. Experience with Resource Agency coordination related to coastal projects. Fluency in coastal physical and ecological processes. Experience and knowledge of the environmental policies and regulations which may require coastal nature-based work to be performed, and that may constrain various approaches to project design and implementation. Excellent technical writing skills. Compensation: $30-$40 hourly* *Final agreed-upon compensation will be based on a variety of factors including, but not limited to, an individual's related experience, education, certifications, skills, and work location. Successful candidates must pass a pre-employment drug test and background check prior to beginning employment. Working Conditions Environment This job operates in an outdoor or office-based environment and this role routinely uses standard office equipment such as computers, phones, printers, etc. Outdoor activity may involve walking/trekking in uneven terrain over long distances in extreme weather conditions for extended periods of time. This job requires project site visits, based outdoors which can include excessive noise, uneven walking surfaces, extreme weather, and moving vehicles and equipment. Physical RequirementsThe physical demands described here are representative of those that must be met to successfully perform the essential functions of the job. This job requires the following: Working on a computer, sitting, or standing for long periods of time in an office or remote office setting. Employees must be capable of bending, squatting, climbing ladders, and lifting up to 35 lbs. unassisted; 50lbs in a team lift (two or more employees). Attending meetings, both in person and virtually, and speaking on the phone with peers, clients, etc. Specific vision abilities, including close vision, distance vision, color vision, peripheral vision, depth perception, and the ability to adjust focus. Dudek is committed to creating a workplace where all employees, regardless of their background, feel valued, respected, and have equal opportunities to succeed. We believe that a diverse and inclusive workforce is essential to our business success, and we are dedicated to fostering a culture where everyone can thrive. We are committed to fair and equitable processes, based on merit, free from any discrimination. Dudek is genuinely committed to equal employment opportunities within our company and on our project teams. Dudek is also committed to compliance with all applicable laws providing equal employment opportunities. This commitment applies to all persons involved in Dudek's operations and prohibits unlawful discrimination by any employee of Dudek, including supervisors and coworkers. Equal employment opportunities will be extended to all persons (including those with disability and veteran status) in all aspects of the employment relationship, including recruitment, hiring, training, promotion, transfer, compensation, benefits, discipline, layoff, recall, and termination. Any employee who violates this policy and Dudek's commitment to equal employment opportunities will be subject to disciplinary action. *As-needed and part-time employees are eligible for our 401(k) plan, sick leave, and our Employee Assistance Program (EAP). As-needed and part-time employees have the option of additional benefits like medical benefits and ESOP participation provided they meet minimum hours worked during the 12-month look back measurement period. Speak with your recruiter to learn more. Dudek is a U.S.-based employer. All positions are based in the United States and require U.S. work authorization.

The Jackson Laboratory in Sacramento, CA has an excellent opportunity for a Scientist to join the Preclinical team! The Scientist may be responsible for designing, executing, and overseeing scientific research projects, applying advanced methodologies and techniques to explore and expand knowledge within a specific discipline. They lead experiments, analyze data, and interpret results while collaborating with interdisciplinary teams to achieve research goals. Key Responsibilities * May Design, plan, and execute experiments, applying advanced scientific principles and methodologies within the field. * Analyze and may interpret experimental data using statistical tools and software, drawing meaningful conclusions and identifying trends. * May prepare research findings for publication in scientific journals, present at conferences, and communicate discoveries to peers and stakeholders. * Lead research initiatives, setting objectives, timelines, and strategies to achieve project goals. * Collaborate with cross-functional teams, providing guidance and mentorship to junior researchers, fostering a collaborative research environment. * Contribute to grant proposals, securing funding for research projects, and managing budgets effectively. Minimum Qualifications * Master's Degree in oncology, immunology, animal pharmacology, or a relevant field required. Ph.D. preferred. * Four or more years of relevant experience in a contract research laboratory, pharmaceutical industry, 6 years preferred * May have a proven track record of conducting high-quality scientific research, evidenced by publications in reputable journals and successful project leadership. * Proficiency in specific methodologies, tools, and instrumentation pertinent to the research area. * Strong leadership, project management, and mentorship abilities to guide and inspire a team of researchers. * Excellent written and verbal communication skills for presenting findings, collaborating with peers, and writing grant proposals. * May have ability to innovate, propose novel approaches, and solve complex scientific problems. * Flexibility to adapt to changing research needs and technologies. * Strong networking skills to establish collaborations and partnerships within the scientific community. * Ability to develop long-term research strategies aligned with organizational goals. The salary range is $99,284-$129,069. Salary will be determined based on qualifications and experience. #CA-AM11 About JAX: The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit ************ EEO Statement: The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.

**Key Responsibilities Include:** - Operate and maintain analytical and **preparative scale HPLC** instrumentation. - Support and troubleshoot walk-up analytical **LC-MS instrumentation** . - Purification of samples from **medicinal chemistry** projects on a milligram to gram scale by preparative HPLC. - Maintain and **troubleshoot NMR spectrometer** under the guidance of senior scientists. - Maintain a high level of productivity in the laboratory setting. - Demonstrate a high degree of responsibility in maintaining scientific standards and safe laboratory practices. - Keep accurate and current records of research and/or project related activities according to company policies. **Qualifications:** - Hands-on experience with **analytical HPLC, preparative HPLC** , mass spectrometry, and/or NMR. - Ability to operate and troubleshoot a variety of hardware/software platforms. - Proven effective written and verbal communication skills and ability to interact with scientists and engineers. - Knowledge of **synthetic organic chemistry** and the ability to communicate effectively with medicinal chemistry team. - Basic understanding of different organic functional groups and organic terminology including enantiomers and diastereomers. - Years of experience/education and/or certifications required: BS, or MS in Organic Chemistry ideal, Analytical Chemistry or closely related field would be ok , with typically 2+ (BS) or 0+ (MS) years of job-related experience **Top 3-5 skills requirements** 1: HPLC, and MS. 2: Analytical LC-MS instrumentation and analytical HPLC instrumentation. **Nice to have** Supercritical fluid chromatography (SFC) About US Tech Solutions: US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit ************************ US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. Responsibilities: The Scientist - TSMS PAR will initially focus on the delivery of parenteral operations, specifically regarding technical transfer and process validation. TSMS PAR Scientists will support one of either formulation, filling, or visual inspection (VI), although may support multiple areas during start-up phase. Upon the start of commercial production, this role's objectives include maintaining the validated state of applicable processes, establishing and monitoring metrics/methods to ensure a state of capability and control, harmonization of control strategies across process teams, evaluate process improvement, and serving as an escalation point for day-to-day operations issues. The role will also author and execute protocols as well as conduct root cause investigations. The principal role is a position that develops and implements a technical agenda and is responsible for providing technical leadership for the Parenteral Process Team. The principal role expected to serve as a mentor within the TSMS team and engage in upstream and external to site activities related to parenteral manufacturing. Key Objectives/Deliverables: * Support the assigned Process Team (formulation, filling, or VI) as TSMS representative. • (Associate/Senior) Serve as floor-level support and technical interface for manufacturing components, equipment, and operations for the TSMS team. * Represent Concord TSMS team for internal and external communications on a regular basis * Lead risk management activities as it pertains to product/process * Provide technical support to non-routine (e.g., deviation, complaint) investigations, including consultation on quality and stability issues * Prepare and Review or approve, as required, relevant technical documents such as: Annual Product Reviews, Change Controls, Regulatory Submissions, Deviations, Validations, Procedures, PFDs, PFMEAs, etc. * Develop, monitor, and appropriately react to established statistically based metrics in real-time to assess process variability and capability * Identify opportunities and lead technical projects to improve process control and/or productivity * Serve as interface with upstream suppliers and parenteral product networks * Drive stability strategy for Concord products * Provide Audit support as needed * Identify opportunities and participate in projects to improve process control and/or productivity Basic Qualifications: * Bachelor's degree or higher an engineering, packaging science, or related field Additional Skills/Preferences: * Pharmaceutical and/or medical device manufacturing experience * Root Cause Investigation Experience * Proficiency with computer systems including Microsoft Office products, Veeva Vault, TrackWise, electronic batch records, and SAP * Demonstrated successful leadership of cross-functional teams * Strong interpersonal and teamwork skills * Strong self-management and organizational skills Additional Information: * Role is Monday through Friday. Must be flexible in providing support to accommodate other inputs (production schedules, shutdowns, etc.). Occasional extended hour and /or off-hour work may be required. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (******************************************************** for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), en Able (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $66,000 - $171,600 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. #WeAreLilly

PromptBio, established in 2023 in Pleasanton, California, is a biotechnology company dedicated to developing AI-driven workflows that automate the discovery of novel biomarkers from multi-omics data, translating them into clinical diagnostic applications. Job Description We seek a motivated Senior Bioinformatics Scientist to join our interdisciplinary team, focusing on integrating AI solutions within the life sciences domain. The role will have significant customer facing responsibilities. Key Responsibilities Work closely with the Business Development team and serve as the primary scientific point of contact for enterprise customers, building deep technical relationships and helping customers derive biological insights. Design and implement custom multi-omics analysis workflows (genomics, transcriptomics, proteomics, metabolomics, epigenomics) tailored to customer use cases Evaluate and incorporate new bioinformatics tools, algorithms, and computational methods to stay at the forefront of the field. Author and contribute to scientific publications, presentations, and IP filings. Qualifications Minimum of 3 years of industry experience in processing and analyzing mutli-omics datasets (e.g., genomics, transcriptomics, proteomics, metabolomics, epigenomics) and deriving meaningful insights Hands-on experience with applying advanced statistical methods and machine learning techniques to analyze omics data and identify novel biomarkers, therapeutic targets, and molecular mechanisms. Excellent publication record and communication skills with ability to explain concepts to diverse audiences. Fluency in programming languages like Python, R, and bioinformatics workflows (e.g., using Nextflow, Snakemake, or similar). Familiarity with software engineering best practices, including testing, code reviews, version control (e.g., Git), and containerization. Experience with cloud computing environments and AI technologies is a significant plus. PhD in Bioinformatics, Computational Biology, Genomics, or related field Desired Attributes Entrepreneurial mindset with comfort in ambiguous, fast-paced environments. Proactive, results-oriented, and driven with a "get things done" mindset. Strong problem-solving skills and adaptability to evolving project requirements. Intellectual curiosity about emerging AI technologies and their biological applications. Collaborative team player who thrives in dynamic environments. Additional Information Financial security through competitive compensation, incentives, and retirement plan Healthcare and well-being programs including competitive medical, dental, and vision benefits Generous paid time-off including vacation, sick time, holidays, and discretionary winter shutdown 401(k) retirement savings with a generous company match Other comprehensive voluntary benefits include but are not limited to pet insurance, life insurance, employee assistance program (EAP), discount programs, and many more We continue to optimize our benefits & wellness programs as we grow our organization to make sure they meet our diverse workforce needs Hybrid work opportunities.

Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. We are seeking a motivated Scientist with experience in genetic metabolic diseases to join our team. The Scientist will join the Enzymatic and Metabolic In Vivo team to design and execute key in vivo studies focused on developing therapeutics to transform the lives of people with genetic metabolic disorders. This role reports into the In Vivo Lead. The primary role of the Scientist will be in design and execution of in vivo studies as part of the Enzymatic and Metabolic In Vivo Team. They will work collaboratively across the Research and Early Development Department to identify, develop and execute project strategies for in vivo testing of novel therapeutics. Areas of focus will span from animal model development to testing novel therapeutic approaches for genetic metabolic disorders. The successful candidate will have a strong background in metabolic and enzymatic biology, with demonstrated experience in the use of model systems in research. Experience with in vivo models of disease and a collaborative mindset is critical. While some industry experience is a plus, it is not required. The successful candidate will contribute in vivo model evaluation and support to project teams that support the project goals. Including in vivo study design, hands on in vivo study performance, selection and characterization of animal models, as well as application of in vivo methods and techniques. Strong written communication skills are critical for FDA filings, writing IACUC protocols, communicating scientific strategy, monitoring in vivo studies and collaborating with CRO's, tissue collection, and sample management. The successful candidate will also have experience with in vivo technical tasks including but not limited to dosing techniques (SC, IP, IV, RO, PO), blood collection (tail nick, saphenous vein puncture), and IVIS imaging. The ideal candidate will have Postdoctoral Academic or Biotech/Pharma industry in vivo experience in the metabolic disease field. The ideal candidate will have hands-on experience with animal models of metabolic/enzymatic disease, a proven track record of high-quality science. Proficiency with in vivo methods such as administration of test articles, perfusion and tissue collection, blood collection, as well as rodent surgical models is required. Candidate level at hire will depend on education and experience. Responsibilities: Research Support * Conduct research on genetic metabolic diseases * Contribute to novel therapeutic programs based on innovative, ground-breaking discoveries that could lead to new, high-impact opportunities for patients * Perform research and publish findings in high-impact journals and present research at major conferences * Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan * Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums * Write, review and contribute to study synopses, protocols, study reports and regulatory documents * Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects * Participate in multi-disciplinary drug development teams and may lead sub-teams * Excellent written and verbal communication * Ability to build/foster productive cross-functional collaborations both within and external to BioMarin * Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice or rats, including health checks and documentation, willalso be required. * Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status including adverse study events. Meticulous electronic lab notebook documentation. * Communicate experimental plans and results to the project team. Support product development and regulatory filings for pivotal clinical studies. * Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines. * Share your knowledge and understanding with other team members * Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs. * Other duties as assigned. * Willingness to work on site full time including off hours and weekends based on study needs. * Other duties as assigned. General requirements for the position: * Demonstrated experience in metabolic biology/disease research in academia or industry (preferred) including publication record * Strong analytical, problem-solving, and decision-making skills * Strong understanding of genetically engineered models, breeding, and management and Gene therapy modalities * Excellent oral and written communication skills * Passion for contributing your scientific skills to develop therapies for patients in need * Must be able to utilize computer databases for analysis, data entry, and point of care observations * Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams * Must be able to work with external regulatory agencies and accreditation groups * Some "off-core business hours" work required * Complete all company training requirement * Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks * This position is an on-site critical required position * Other duties as assigned Education and Experience Requirements: * PhD in a related subject area with demonstrated in vivo research experience in metabolic disease * Postdoctoral or industry (2-5 years preferred) experience in genetic metabolic diseases * Extensive hands-on experience with rodent in vivo work in the metabolic field This position is full-time on-site and based in Petaluma, CA with occasional work on site in San Rafael, CA Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. The salary range for this position is: $116,000 to $159,500. BioMarin considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans. For additional benefits information, visit:

The Senior Toxicologist serves as the Chief of the Cancer Toxicology and Epidemiology Section (CTES), within the Reproductive and Cancer Hazard Assessment Branch (RCHAB). CTES provides technical support for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65), including identifying chemicals for consideration for listing as carcinogens under Proposition 65, conducting dose-response and exposure assessments, and developing carcinogen risk assessment guidance and methodology. CTES also provides technical assistance to other programs in the Office of Environmental Health Hazard Assessment (OEHHA), the Attorney General's Office, and other California government entities. The Senior Toxicologist supervises the activities of the personnel in CTES and provides expert scientific and management supervision of Section projects by coordinating, as appropriate, with the Chief of RCHAB, and other programs within OEHHA. Duties include the direct supervision of Section staff, granting time off, and coordinating various projects involving other parts of the department. The incumbent will review the work of staff and will be responsible for the most sensitive documents prepared by the Section. Please let us know how you heard about this position by taking a brief survey: ************************************** LIST ELIGIBILITY - EXAMINATION PROCESS List eligibility is established through an examination process in which one must apply and successfully pass the examination for the classification. If you have not established list eligibility for the Senior Toxicologist, please click on the link to the examination bulletin for more information - ******************************************************************************** You will find additional information about the job in the Duty Statement. Working Conditions OEHHA has a hybrid work environment that includes work in an office setting in a high-rise building and telework at home. Requires extended periods of reading and writing, frequently using computer workstations, and data and word processing software. Work in office space may not have direct natural lighting. Day trips and overnight travel may be required to attend meetings, public hearings, and/or to work with other governmental entities to complete projects and work assignments. May be required to travel to other locations for business related needs as necessary. This position may be located either at 1515 Clay Street, 16th Floor, Oakland, or at 1001 I Street, 12th Floor, Sacramento, California. Minimum Requirements You will find the Minimum Requirements in the Class Specification. * SENIOR TOXICOLOGIST Additional Documents * Job Application Package Checklist * Duty Statement Position Details Job Code #: JC-484890 Position #(s): 811-140-7943-006 Working Title: Chief, Cancer Toxicology and Epidemiology Section Classification: SENIOR TOXICOLOGIST $12,295.00 - $15,730.00 New to State candidates will be hired into the minimum salary of the classification or minimum of alternate range when applicable. # of Positions: 1 Work Location: United States Telework: Hybrid Job Type: Permanent, Full Time Department Information The Office of Environmental Health Hazard Assessment (OEHHA) values diversity, equity, and inclusion throughout the organization. We foster an environment where employees from a variety of backgrounds, cultures, and personal experiences are welcomed and can thrive. We believe the diversity of our employees is essential to inspiring innovative solutions. Together we further our mission to protect and enhance the health of Californians and our state's environment through scientific evaluations that inform, support and guide regulatory and other actions. Join OEHHA to improve the lives of all Californians. OEHHA is a small agency that will provide lots of varied experience. OEHHA is responsible for developing and providing risk managers in state and local government agencies with toxicological and medical information relevant to decisions involving public health. Department Website: ************************ This position may be eligible for hybrid telework under Government Code 14200 for eligible applicants residing in California, subject to the candidate meeting telework eligibility criteria set forth in the CalEPA telework policy and/or future program need. Employees not residing in California are not eligible for telework. Regardless of telework eligibility, all employees may be required to report to the position's designated headquarters location, as indicated on their duty statement, at their own expense. Special Requirements Electronic applications through your Cal Career Account are highly recommended. We highly recommend electronic submission of applications. Applications Packages may be submitted electronically through your CalCareer Account by 11:59 p.m. on or before the above final filling date. Electronic applications submitted through your CalCareer Account are highly recommended and will be received faster that other methods of applying. Application Instructions Dates printed on Mobile Bar Codes, such as the Quick Response (QR) Codes available at the USPS, are not considered Postmark dates for the purpose of determining timely filing of an application. Final Filing Date: Until Filled Who May Apply Individuals who are currently in the classification, eligible for lateral transfer, eligible for reinstatement, have list or LEAP eligibility, are in the process of obtaining list eligibility, or have SROA and/or Surplus eligibility (please attach your letter, if available). SROA and Surplus candidates are given priority; therefore, individuals with other eligibility may be considered in the event no SROA or Surplus candidates apply. Applications will be screened and only the most qualified applicants will be selected to move forward in the selection process. Applicants must meet the Minimum Qualifications stated in the Classification Specification(s). How To Apply Complete Application Packages (including your Examination/Employment Application (STD 678) and applicable or required documents) must be submitted to apply for this Job Posting. Application Packages may be submitted electronically through your CalCareer Account at ********************** When submitting your application in hard copy, a completed copy of the Application Package listing must be included. If you choose to not apply electronically, a hard copy application package may be submitted through an alternative method listed below: Address for Mailing Application Packages You may submit your application and any applicable or required documents to: Environmental Health Hazard Assessment Office N/A Attn: Julia Rollison - JC-484890 P.O. Box 67 1001 I Street, 12th Floor Sacramento, CA 95812-0067 Address for Drop-Off Application Packages You may drop off your application and any applicable or required documents at: Environmental Health Hazard Assessment Office N/A Julia Rollison- JC-484890 P.O. Box 67 1001 I Street, 12th Floor Sacramento, CA 95812-0067 10:00 AM - 05:00 PM Required Application Package Documents The following items are required to be submitted with your application. Applicants who do not submit the required items timely may not be considered for this job: * Current version of the State Examination/Employment Application STD Form 678 (when not applying electronically), or the Electronic State Employment Application through your Applicant Account at ********************** All Experience and Education relating to the Minimum Qualifications listed on the Classification Specification should be included to demonstrate how you meet the Minimum Qualifications for the position. * Resume is required and must be included. * Statement of Qualifications - Please see Statement of Qualifications below. * Other - Curriculum Vitae Applicants requiring reasonable accommodations for the hiring interview process must request the necessary accommodations if scheduled for a hiring interview. The request should be made at the time of contact to schedule the interview. Questions regarding reasonable accommodations may be directed to the EEO contact listed on this job posting. Desirable Qualifications In addition to evaluating each candidate's relative ability, as demonstrated by quality and breadth of experience, the following factors will provide the basis for competitively evaluating each candidate: * Knowledge and proficiency in general principles of toxicology, with an emphasis in the area of carcinogenesis. * An understanding of the general principles of public health and risk assessment. * Ability to critically review and evaluate highly complex scientific studies and other information relevant to carcinogen risk assessment. * Knowledge of principles and techniques of effective supervision. * Ability to produce high quality work products that clearly and concisely convey scientific findings and concepts. * Ability to function effectively and work cooperatively in a team. * Ability to communicate complex technical matters effectively in person and in writing. * Ability to analyze situations accurately and take effective action in a timely manner. * Ability to produce high quality written reports. * Knowledge of statistical and dose-response modeling software. Benefits In addition to a compelling vision for California, the Office of Environmental Health Hazard Assessment offers competitive pay, benefits, and features for its workforce. To review the pay and benefits offered to California civil service staff, please review CalHR's website at ************************************************************* Contact Information The Human Resources Contact is available to answer questions regarding the application process. The Hiring Unit Contact is available to answer questions regarding the position. Human Resources Contact: Julia Rollison ************** *************************** Hiring Unit Contact: Brian Brown ************** ************************ Please direct requests for Reasonable Accommodations to the interview scheduler at the time the interview is being scheduled. You may direct any additional questions regarding Reasonable Accommodations or Equal Employment Opportunity for this position(s) to the Department's EEO Office. EEO Contact: Cassaundra Willis ************** ****************************** California Relay Service: ************** (TTY), ************** (Voice) TTY is a Telecommunications Device for the Deaf, and is reachable only from phones equipped with a TTY Device. APPLICATION INFORMATION All applicable fields on the State Application Form (STD. 678) must be filled out completely. Clearly indicate on the Form STD. 678 in the field titled "Examination(s) or Job Titles for Which You Are Applying" the position as Senior Toxicologist - Job Code (JC)-460026 as indicated on this job announcement and your basis of eligibility (*list eligibility, lateral transfer, reinstatement, etc.). Employment history on your application must be complete with dates, description of duties and responsibilities for each position held, contact names and phone numbers of supervisors. Applicants who do not submit all of the required documentation (incomplete application package) may be eliminated from the selection process. Statement of Qualifications The Statement of Qualifications (SOQ) serves as documentation of your ability to present information clearly and concisely in writing. The SOQ is a narrative discussion, not a bulleted summary. Please answer each of the following questions for the SOQ. Identify each response with the number of the SOQ question, single-spaced, and using Arial 12-point font. The SOQ should be no more than three (3) pages in length. * Describe how your education, experience, and other skills qualify you to effectively direct a multidisciplinary team of scientists to conduct scientifically rigorous, accurate, and complete evaluations and analyses of scientific studies that provide evidence relevant to the evaluation of cancer hazards and/or cancer risks of specific chemicals and chemical substances. * Discuss your role and contributions to a project that involved the evaluation and analysis of a complex set of toxicological issues and data related to assessing cancer hazards and/or cancer risks. Include a brief description of the methods applied, the analyses conducted, and the key outcomes of the project. * Describe your experience giving oral presentations on issues related to cancer hazards and/or cancer risks at scientific conferences, meetings of expert panels, or other public meetings. Equal Opportunity Employer The State of California is an equal opportunity employer to all, regardless of age, ancestry, color, disability (mental and physical), exercising the right to family care and medical leave, gender, gender expression, gender identity, genetic information, marital status, medical condition, military or veteran status, national origin, political affiliation, race, religious creed, sex (includes pregnancy, childbirth, breastfeeding and related medical conditions), and sexual orientation. It is an objective of the State of California to achieve a drug-free work place. Any applicant for state employment will be expected to behave in accordance with this objective because the use of illegal drugs is inconsistent with the law of the State, the rules governing Civil Service, and the special trust placed in public servants.

About KariusKarius is a life science, venture-backed clinical metagenomics company, focused on elevating patient care through microbial insights. We are committed to advancing diagnostic science and technology to optimize the diagnosis and treatment of infectious diseases. Through the use of genomics and AI, we are driven to improve the diagnostic landscape for infectious diseases. Karius delivers unprecedented diagnostic insight detecting microbial cell-free DNA circulating in the body to assist physicians to make rapid treatment decisions. Why Should You Join Us?Karius' core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease. Position SummaryYou are highly curious, creative, and driven by a desire for continuous growth with the ultimate goal of making a meaningful impact on patients' lives. As a key and integral member of the Computational Biomarker Discovery team, you will focus on deeply exploring and analyzing the complex biological interplay between diverse conditions and molecular data. In this role, you will help unlock and help unlock preliminary biological signatures to inform translational science and precision medicine beyond the conventional infectious disease arena, and into areas such as autoimmune and cancer. You will design analysis plans, execute computational workflows, partner for method and machine learning model development, and integrate biological rationale with data-driven insights to uncover meaningful connections. You bring a passion for applying technology in novel ways, generating innovative hypotheses, and revealing hidden patterns in data. Your curiosity and analytical rigor will drive discoveries that push the boundaries of biomarker research and patient care. Reports to: Director, Computational Biomarker Discovery Location: Redwood City, CA (Hybrid) or Remote (USA) Primary Responsibilities• Lead data analysis and interpretation of complex biological datasets, including next-generation sequencing (NGS), metagenomics, transcriptomics, fragmentomics, and single-cell analysis.• Create or adapt computational tools and algorithms to support biomarker discovery and workflows.• Drive bioinformatics aspects of cross-functional research projects in collaboration with scientific and medical leaders, under the guidance of the Director of Computational Biomarker Discovery.• Conduct deep exploration of the biological interplay between molecular data and disease conditions, generating insights to advance translational science.• Deliver preliminary biological signatures that inform precision medicine applications beyond infectious disease, including autoimmune disorders and oncology.• Partner in experimental design by defining analysis plans, selecting appropriate methodologies, and executing computational analyses with a strong grounding in biological rationale.• Collaborate closely with scientific, medical, engineering, and commercial teams to set company goals and support the development of new partnerships and products.• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.• Share enthusiasm for exploring novel applications of Karius' technology platform to drive innovation and impact. What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. Travel: Travel to HQ on a quarterly basis if remote. Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment. Position Requirements• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master's degree with 5+ years of directly relevant industry experience.• Publications demonstrating the use of innovative mathematical or computational models to investigate and interpret biological and biomarker data.• Strong background in modern statistics and machine learning, including applications to biomarker discovery.• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.• Self-starter with the ability to independently drive results and influence project direction.• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host-environment interactions.• Deep understanding and hands-on experience with bioinformatics tools, methods, and workflows, especially those related to next-generation sequencing (NGS) data analysis.• Familiarity with exploratory study and clinical trial designs and analyses, particularly in pharmaceutical or biotechnology applications. Personal Qualifications• Passionate, purpose-driven, and excited about Karius' mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.• Excellence at communication and collaboration within a cross-functional team.• Detail oriented with exceptional organizational and time management skills.• Self-starting mentality and ability to drive results.• Comfortable working in an environment which combines both research aspects as well as development.• Ability to work effectively and efficiently in a fast-paced (startup) environment. DisclaimerThe above is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of Karius. Equal Opportunity EmployerAt Karius, we value a diverse and inclusive workplace and provide equal employment opportunities for all applicants and employees and are committed to honor and invest in the full diversity of people, in our hiring, recruiting and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. If you are unable to submit your application due to a disability, please contact us at [email protected] and we will accommodate qualified individuals with disabilities. $142,231 - $213,347 a year

Description Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. About Worldwide Research and Development From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. We are seeking a motivated Scientist with experience in genetic metabolic diseases to join our team. The Scientist will join the Enzymatic and Metabolic In Vivo team to design and execute key in vivo studies focused on developing therapeutics to transform the lives of people with genetic metabolic disorders. This role reports into the In Vivo Lead. The primary role of the Scientist will be in design and execution of in vivo studies as part of the Enzymatic and Metabolic In Vivo Team. They will work collaboratively across the Research and Early Development Department to identify, develop and execute project strategies for in vivo testing of novel therapeutics. Areas of focus will span from animal model development to testing novel therapeutic approaches for genetic metabolic disorders. The successful candidate will have a strong background in metabolic and enzymatic biology, with demonstrated experience in the use of model systems in research. Experience with in vivo models of disease and a collaborative mindset is critical. While some industry experience is a plus, it is not required. The successful candidate will contribute in vivo model evaluation and support to project teams that support the project goals. Including in vivo study design, hands on in vivo study performance, selection and characterization of animal models, as well as application of in vivo methods and techniques. Strong written communication skills are critical for FDA filings, writing IACUC protocols, communicating scientific strategy, monitoring in vivo studies and collaborating with CRO's, tissue collection, and sample management. The successful candidate will also have experience with in vivo technical tasks including but not limited to dosing techniques (SC, IP, IV, RO, PO), blood collection (tail nick, saphenous vein puncture), and IVIS imaging. The ideal candidate will have Postdoctoral Academic or Biotech/Pharma industry in vivo experience in the metabolic disease field. The ideal candidate will have hands-on experience with animal models of metabolic/enzymatic disease, a proven track record of high-quality science. Proficiency with in vivo methods such as administration of test articles, perfusion and tissue collection, blood collection, as well as rodent surgical models is required. Candidate level at hire will depend on education and experience.Responsibilities: Research Support Conduct research on genetic metabolic diseases Contribute to novel therapeutic programs based on innovative, ground-breaking discoveries that could lead to new, high-impact opportunities for patients Perform research and publish findings in high-impact journals and present research at major conferences Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums Write, review and contribute to study synopses, protocols, study reports and regulatory documents Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects Participate in multi-disciplinary drug development teams and may lead sub-teams Excellent written and verbal communication Ability to build/foster productive cross-functional collaborations both within and external to BioMarin Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice or rats, including health checks and documentation, will also be required. Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status including adverse study events. Meticulous electronic lab notebook documentation. Communicate experimental plans and results to the project team. Support product development and regulatory filings for pivotal clinical studies. Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines. Share your knowledge and understanding with other team members Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs. Other duties as assigned. Willingness to work on site full time including off hours and weekends based on study needs. Other duties as assigned. General requirements for the position: Demonstrated experience in metabolic biology/disease research in academia or industry (preferred) including publication record Strong analytical, problem-solving, and decision-making skills Strong understanding of genetically engineered models, breeding, and management and Gene therapy modalities Excellent oral and written communication skills Passion for contributing your scientific skills to develop therapies for patients in need Must be able to utilize computer databases for analysis, data entry, and point of care observations Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams Must be able to work with external regulatory agencies and accreditation groups Some "off-core business hours" work required Complete all company training requirement Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks This position is an on-site critical required position Other duties as assigned Education and Experience Requirements: PhD in a related subject area with demonstrated in vivo research experience in metabolic disease Postdoctoral or industry (2-5 years preferred) experience in genetic metabolic diseases Extensive hands-on experience with rodent in vivo work in the metabolic field This position is full-time on-site and based in Petaluma, CA with occasional work on site in San Rafael, CA Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.