Senior principal scientist jobs in Chula Vista, CA - 325 jobs

Cambridge UK (On-site) About AstraZeneca AstraZeneca is a global, science‑led, patient‑focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death. Come and join our AZ team where you will play a pivotal role in this exciting period of development! As an Associate Principal Scientist, you'll spearhead the development of innovative bioconjugates, pushing the boundaries of science to develop life‑changing medicines. Join us in exploring new frontiers and making a significant impact on global healthcare. Key Responsibilities Lead antibody‑based conjugation projects for both technology development and inclusion in our bioconjugate portfolio. Conceive, design, and synthesize high‑quality antibody conjugates (ADCs, bispecifics/tri‑specifics etc.) using lysine, cysteine, engineered‑cysteine and enzymatic chemistries. Select payloads and rationally design conjugate architectures to optimise stability, payload-antibody ratios (DAR/PAR/OAR), pharmacology, and on‑target potency balance and efficacy. Lead hands‑on expression, conjugation and purification at small‑to‑mid‑scale material (up to gram‑scale), establish robust SOPs, and deliver materials to internal stakeholders on schedule. Express and characterise antibodies, VHHs and fusion constructs; perform bioconjugation, binding assays, and developability assessments. Extensive experience in protein engineering related to antibody conjugate optimisation such as half‑life extension, effector silencing, Fc engineering for thermal stability. Own analytical QC across SEC, HIC, RP‑HPLC, IEX, native and denaturing SEC‑MS. Partner with cross‑functional teams (e.g., therapy area partners, senior leaders, protein engineering, bioanalytics, pharmacology) to set experimental strategy, interpret data, and move programmes through appropriate milestones. Contribute to IP (inventions/patents) and publications; present at internal governance and external conferences. Mentor junior scientists and (where applicable) and matrix‑manage pipeline and technology projects in support of antibody‑conjugates by championing high standards in safety, quality and scientific rigour. Requirements PhD (or equivalent) in Chemical Biology, Biochemistry, Pharmaceutical Sciences, Chemistry or a related field and 8 years' hands‑on experience in bioconjugation/ADCs in biotech/pharma. Demonstrated track record progressing conjugate therapeutics (e.g., ADCs etc.) through key discovery gates and into pre‑clinical development. Deep expertise in bioconjugation chemistries (lysine, cysteine/engineered cysteine, enzymatic); ability to tailor conjugation routes to format, payload and developability constraints. Payload selection and linker-payload design (cleavable/non‑cleavable; acid‑labile, enzyme‑cleavable; rebridging and site‑specific strategies); strong SAR approach. Protein expression and purification (IgG, VHH, fusion constructs) with hands‑on experience in bioconjugation, purification and QC release. Mastery of analytics: SEC/HIC/RP‑HPLC/SAX; LC‑ESI‑MS (native SEC‑MS and denaturing RP‑MS); data analysis and interpretation for batch release and comparability. Proven ability to lead deliverables, communicate progress to cross‑functional leadership, and present complex results to governance/senior stakeholders. Exposure to Fc‑engineering (e.g., FcγR mutations, half‑life modulation) with cell assay execution. Familiarity with display technologies and protein engineering concepts to support conjugation site selection and format design. Experience authoring patents/manuscripts and contributing to articles & grants; effective scientific writing. Desirables Experience in application of AI design methodologies for bioconjugate development i.e. payload site placement, conjugation efficiency, developability or stability. Functional and primary cell assay design and execution (ADCC/ADCP; internalisation; efferocytosis) and associated data analysis/statistics. Familiarity with dual‑payload strategies and rebridging approaches. Broad bioassay toolkit: reporter assays (luciferase/SEAP), flow‑based internalisation, confocal imaging, Incucyte‑based live‑cell readouts. In Office Requirement When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life‑changing medicines. In‑person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of five days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Why AstraZeneca? At AstraZeneca's Oncology R&D business area, you'll be part of a team playing a critical role in driving meaningful change in the way we predict, prevent and treat patients' conditions. We're actively embracing and investing in technology, harnessing digital, data and analytics to reimagine the future of healthcare and deliver improved outcomes to patients beyond core medical. We're shaping the future, improving and speeding up portfolio development, improving the patient experience and outcomes at clinical trials. Join the team that is co‑creating a digital ecosystem with patients at its core. Competitive salary and benefits package on offer. The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, and a performance recognition scheme and a competitive, generous remuneration package. Date Posted 15-Jan-2026 Closing Date 23-Jan-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. #J-18808-Ljbffr

Genesis Molecular AI is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Principal CADD Scientist to join our team, working directly with scientists in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US. What You Will Do (Key Responsibilities) Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents. Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts. Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches. Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making. Adapt to a fast-paced environment where innovation and quick iteration are encouraged. What you'll bring PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD. Deep understanding of structure-based drug design and protein-ligand interactions. Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite. Minimum of 5+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs. Onsite in our San Diego lab is preferred for this role, to be able to collaborate with our scientists. We are open to remote team members too. What we offer Competitive Pay Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees) Stock Option Eligibility 401(k) Plan Open PTO Policy Paid Company Holidays Subsidized lunch and snacks at our offices Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company's generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets. Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer. #J-18808-Ljbffr

Come join our collaborative and creative group of AI scientists and machine learning engineers and build models that directly affect hundreds of thousands of our customers. In this role you will be building and deploying machine learning models using both analytical algorithms and deep learning approaches. We are waiting for you to join us and do the best work of your life. Responsibilities Practices excellent leadership and communication skills to influence and lead teams and to evangelize AI science across the organization Leads team's work in one or more of: ML, NLP, Statistics, or Optimization, performs hand-on work in these domains. Weighs ROI considerations of general and tailored capabilities for projects in the team Creates new capabilities that solve critical business problems Pushes the boundaries of ML by developing foundational methods and novel applications from state-of-the-art ML technologies and industry trends Influences business leaders to shape mission critical projects Creates multi-year vision that connects product strategy with technology strategy Drives architecture decisions, influences and contributes to ML platform architecture and strategy Leads team and partners to the successful delivery and integration of ML solutions Conducts design reviews, holds teams to technical and operational rigor Acts as an advisor in overseeing and mentoring the work of colleagues towards the building of a vibrant practice community Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing pay equity for employees, Intuit conducts regular comparisons across categories of ethnicity and gender. Qualifications PhD/MS in Engineering Mathematics, Statistics, Theoretical/Computational Physics, or related field Solid knowledge of statistical techniques 3+ years as either a lead in a AI science role or in a management position in AI science Strong communication skills and proven experience as an influencer at the executive level Hands-on programming experience and expert knowledge in one or more of: ML, NLP, Statistics, or Optimization 6+ years' experience manipulating large datasets and using databases (e.g. R, SQL, S-Plus, etc.) 6+ years' experience with a general-purpose programming language (e.g. Python, Scala, etc.) Expert knowledge and hands-on experience with ML pipelines, processes, and design patterns Proven track record of influencing business leaders to shape mission critical projects Proven track record of leading team to successful delivery of ML solutions Strong interpersonal and communication skills in order to effectively contribute to technical teams and make presentations to a variety of technical and business personnel Intuit provides a competitive compensation package with a strong pay for performance rewards approach. This position will be eligible for a cash bonus, equity rewards and benefits, in accordance with our applicable plans and programs (see more about our compensation and benefits at Intuit : Careers | Benefits). Pay offered is based on factors such as job-related knowledge, skills, experience, and work location. To drive ongoing fair pay for employees, Intuit conducts regular comparisons across categories of ethnicity and gender. The expected base pay range for this position is: Southern California, CA: $237,000 - $320,500 #J-18808-Ljbffr

A biopharmaceutical company in San Diego seeks a Principal Scientist to lead an in vitro pharmacology team. Candidates should have a Ph.D. and over 8 years in drug discovery, particularly with GPCRs. Responsibilities include designing assays, managing a team, and collaborating on research projects. The competitive salary ranges from $158,000 to $197,000, with comprehensive benefits including health insurance and PTO. #J-18808-Ljbffr

Postdoctoral Scientist - Svendsen Lab - Regenerative Medicine Institute (Onsite) at CEDARS-SINAI summary: The Postdoctoral Scientist at Cedars-Sinai's Svendsen Lab conducts independent and collaborative research focused on neurodegenerative diseases using stem cell technologies. Responsibilities include designing and performing experiments, data analysis, maintaining laboratory equipment, and contributing to scientific publications and presentations. The role requires a doctorate degree and strong technical and communication skills in a specialized biomedical research environment. Job Description The Svendsen Lab at Cedars-Sinai Medical Center, Regenerative Medicine Institute is looking for a Postdoctoral Scientist to join the team! When the work you do every single day has a crucial impact on the lives of others, every effort, every detail, and every second matters. This shared culture of happiness, passion, and dedication pulses through Cedars-Sinai, and it's just one of the many reasons why we rank as one of the top hospitals in the nation by U.S. News & World Report. Are you ready to be a part of breakthrough research? The mission of the Svendsen Laboratory is to study neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), spinal muscular atrophy (SMA), Parkinson's disease (PD), and Allan-Herndon-Dudley syndrome (AHDS) using stem cells as a disease treatment, as well as a tool for modeling these diseases in vitro. Clive Svendsen, PhD, has significant experience in studying these diseases over the last twenty years and is merging his experience with the use of groundbreaking technologies, such as inducible pluripotent stem cells (iPSC cells). To learn more, please visit Svendsen Research Lab | Cedars-Sinai (cedars-sinai.edu). The Postdoctoral Scientist works independently but in close cooperation and consultation with the Principal Investigator and other Research Scientists. The incumbent will perform routine and complex laboratory procedures throughout training period. May develop, adapt, and implement new research techniques and protocols. Analyzes and interprets data. Please note that this position is onsite. Primary Job Duties and Responsibilities: May assist in the preparation of grant proposals, but is not responsible for generating grant funds. May participate in publications and presentations as author or co-author. Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator. Analyzes interpret, summarizes, and compiles data. Operates and maintains equipment and instruments. May observe MD-patient or MD-human research subject interactions as they pertain directly to research being performed. Qualifications Education: • Doctorate (MD, PhD, VMD, or DDS) in the area directly related to the field of research specialization. Experience and Skills: Acquires thorough technical and theoretical knowledge of research project and objectives during one to fiveyear post-doctoral appointment. Works independently on research projects designed by a mentor (typically the PI) within area of specialization. Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, analysis, operation, and maintenance of specialized equipment. Scheduling flexibility including evening, weekend, and holiday rotation commitments may be necessary. Travel may be required. Function efficiently and cooperatively with a team of faculty, research associates, technicians, and students. Excellent written and oral communication skills are essential. Knowledge of safety standards and maintenance of specialized equipment. About UsCedars-Sinai is a leader in providing high-quality healthcare encompassing primary care, specialized medicine and research. Since 1902, Cedars-Sinai has evolved to meet the needs of one of the most diverse regions in the nation, setting standards in quality and innovative patient care, research, teaching and community service. Today, Cedars- Sinai is known for its national leadership in transforming healthcare for the benefit of patients. Cedars-Sinai impacts the future of healthcare by developing new approaches to treatment and educating tomorrow's health professionals. Additionally, Cedars-Sinai demonstrates a commitment to the community through programs that improve the health of its most vulnerable residents. About the TeamCedars-Sinai is one of the largest nonprofit academic medical centers in the U.S., with 886 licensed beds, 2,100 physicians, 2,800 nurses and thousands of other healthcare professionals and staff. Choose this if you want to work in a fast-paced environment that offers the highest level of care to people in the Los Angeles that need our care the most. Req ID : 13004 Working Title : Postdoctoral Scientist - Svendsen Lab - Regenerative Medicine Institute (Onsite) Department : Research - RMI Business Entity : Cedars-Sinai Medical Center Job Category : Academic / Research Job Specialty : Postdoctoral Scholar Overtime Status : EXEMPT Primary Shift : Day Shift Duration : 8 hour Base Pay : $62,400.00 - $93,600.00 Keywords: postdoctoral scientist, regenerative medicine, neurodegenerative diseases, stem cells, medical research, laboratory experiments, data analysis, iPSC, scientific publications, Cedars-Sinai

A global analytics software company is seeking a Principal Scientist in San Diego, CA to lead teams in developing predictive models and analyzing data. This role requires an MS or PhD in a related field with a strong background in predictive modeling and software development (C, C++, or Java). The successful candidate will drive innovation, present findings to clients, and ensure optimal model performance. The company offers competitive compensation and a collaborative work environment. #J-18808-Ljbffr

Scientist - Functional Method Development & Transfer (MDT) Duration: 6-month contract Schedule: Standard working hours Pay: 40-44 USD/per hour Must-Have Skills Strong attention to detail Advanced Excel & Microsoft Word GMP / Good Documentation Practices Lab management experience Molecular biology bench experience Next-Generation Sequencing (NGS) Strong interpersonal, verbal, and written communication Presentation skills Nice to Have Equipment maintenance & onboarding Library preparation Stability testing Statistical analysis Test method validation Job Overview The Functional Method Development & Transfer (MDT) group supports manufacturing by providing technical and operational leadership for: New product introduction (NPI) Process optimization to improve quality and yield Development and validation of functional nucleic-acid based test methods This is a hands-on, independent role requiring close collaboration with R&D, Quality, Production, and Engineering teams to ensure successful technology transfer into a GMP manufacturing environment. Support with general lab management and equipment onboarding may also be required. Key Responsibilities Perform laboratory work following written protocols and execute assigned test methods Help establish process and QC method requirements to meet product specifications Partner with NPI teams throughout the Product Development Process (PDP) Act as liaison between development and manufacturing Design and execute controlled experiments (DOEs, gauge R&R studies) Support qualification and validation activities Monitor and analyze results from development and pilot lots Investigate off-target outputs and perform root cause analysis Provide technical and compliance recommendations Present clear written and oral communications in technical meetings Author technical documents: protocols, reports, SOPs, and manufacturing documentation Support software and instrument validation for NPI transfer into Reagent QC Assist with general lab maintenance and equipment onboarding Requirements Ability to support process and test method development activities Knowledge of laboratory techniques such as: Library preparation NGS workflows Nucleic acid methods (PCR, probe enrichment/hybridization) Biochemical/enzymatic assays Strong cross-functional communication and collaboration skills Ability to thrive in a fast-paced, changing environment Capability to take ownership of lab maintenance and onboarding tasks Highly Desired Experience troubleshooting automation workflows (Hamilton / Tecan) Strong proficiency with library prep and NGS techniques Education & Experience B.S., M.S., or PhD in Biochemistry, Chemistry, Biological Sciences, Physical Chemistry, or related field 3+ years of relevant experience ...

A leading global healthcare firm in San Diego is seeking a highly motivated scientist to contribute to biotherapeutics development. The successful candidate will discover and engineer antibodies, oversee experiments, and utilize various molecular biology techniques. Applicants should have at least 6 years of relevant experience and a strong background in flow cytometry. This position offers competitive compensation ranging from $110,250 to $187,000 along with comprehensive benefits. #J-18808-Ljbffr

A global healthcare company based in San Diego is looking for an experienced scientist to lead biologics discovery and development. This role involves working cross-functionally with Immunology teams and external partners to innovate therapeutics focusing on antibodies and multicentric projects. Candidates should possess a strong background in protein therapeutics with respective educational qualifications and experience. A commitment to diversity and inclusion within the workplace is essential. #J-18808-Ljbffr

DescriptionField Technical Support Scientist (Mass Spectrometry) Location: Los Angeles, CA Salary: $97,000 - $99,500 per year * Based on your location, a Cost of Living Adjustment (COLA) is available as part of the total compensation package Who are we? Established in 1975, Shimadzu Scientific Instruments is one of the largest suppliers of analytical instrumentation, physical testing, and environmental monitoring systems in the world. Ground-breaking scientific research, manufacturing ideas and results continue to propel Shimazu's outstanding reputation and "Excellence in Science." People dedicated to our mission have the largest impact on Shimadzu's continued growth and success. Would YOU like to join a diverse team of professionals working together with researchers, scientists and manufacturers to help better lives worldwide? What can Shimadzu offer YOU? Our Culture - A work environment that values diversity, inclusion & belonging Competitive Compensation - Day 1 Benefits & Competitive Salary Retirement Benefits - Matching 401K & Profit-Sharing Program Professional Growth - Clear pathways for Career, Leadership and Personal Development Health Benefits - Flexible Spending/Health Savings Accounts Work-Life Balance - Generous & Front-Loaded Paid Time Off Plan Education - Tuition Assistance Program for both graduate and undergraduate levels Insurance Perks - Pet Insurance, optional Identity theft, legal pre-paid and critical care buy-up insurance benefits, generous company paid life insurance & short-term disability programs Work Flexibility - Business casual Dress Attire & casual (jeans) Friday! Employee Engagement - Employee Resource Groups to network, build a sense of community and enhance one's career and personal development ADDITIONAL COMPENSATION: For Service, Technical Support, Marketing & Sales Roles: Additional compensation is available through either an Incentive and/or Commission Plan. For Employees residing in Connecticut, Massachusetts, New Jersey, and California: Additional compensation is offered through a Cost-of-Living Adjustment (COLA). Position Summary: Shimadzu Scientific Instruments is seeking an MS Technical Support Scientist to join our team and provide expert technical support for our LC-MS products. In this role, you'll support our sales teams by conducting product demonstrations, installations, training, and post-sales assistance to ensure our customers maximize the value of their instrumentation. If you thrive in a customer-facing, technical environment and enjoy collaborating with a dynamic team, this position could be the perfect fit for you. JOB FUNCTIONS INCLUDE, BUT ARE NOT LIMITED TO: Provide technical expertise during sales calls and product demonstrations. Conduct training sessions for customers and regional personnel. Run customer samples and develop application notes to showcase Shimadzu's LC-MS capabilities. Assist customers with adapting their analytical methodologies for our MS products. Oversee the regional MS demonstration inventory. Frequent travel to customer sites and regional offices (20%-50% overnight travel). Support and collaborate with regional teams and assist with training new technical support specialists. EDUCATION AND QUALIFICATIONS: Bachelor's degree in Chemistry or a related field (MS or PhD preferred). At least 1 year of laboratory experience with LC-MS instrumentation. Strong communication and problem-solving skills, ability to interpret analytical data, and excellent customer relations. Valid driver's license and willingness to travel. At Shimadzu Scientific Instruments, we believe in providing structured career paths that recognize and reward talent. If your expertise surpasses the level specified in the listed position, we offer the flexibility to upgrade positions to better suit your qualifications, accompanied by a salary adjustment. COMPENSATION AND BENEFITS: This exempt, full-time position comes with a competitive salary range of $95,000 to $97,500 annually, paid semi-monthly. Eligible benefits include a 401K matching program and discretionary yearly contributions, with detailed information provided at the final interview stage. In your first year, you will receive 10 paid vacation days, 8 paid personal days (or state sick leave in California/Puerto Rico), 8 scheduled holidays, and 3 floating holidays. After one year, you'll have access to a generous short-term disability program, with premiums fully covered by the company. Employees are insured at 100% of their salary for the first 6 weeks and 66 2/3% for weeks 7 to 12. Additional variable compensation includes an incentive plan based on performance goals, paid semi-annually in April and October, along with a potential discretionary year-end bonus. The offer also includes a company car (with a $55 deduction for personal use) and a company phone, fully funded by the employer, which remains company property but can be used for personal calls. For more details on benefits, please visit ************************** Shimadzu is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Shimadzu via email, the Internet or in any form and/or method without a valid written search agreement in place for this position (and agency was requested to work the requisition) will be deemed the sole property of Shimadzu. No fee will be paid in the event the candidate is hired by Shimadzu as a result of the referral or through other means. EEO Statement: Shimadzu Scientific Instruments (SSI) is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to age, ancestry, citizenship, color, family or medical care leave, gender identity or expression, genetic information, immigration status, marital status, medical condition, national origin, physical or mental disability, political affiliation, protected veteran or military status, race, ethnicity, religion, sex (including pregnancy), sexual orientation, or any other characteristic protected by applicable local laws, regulations and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application process, please click here . Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.

Neomorph is seeking a highly experienced and strategically minded Associate Principal Scientist or Principal Scientist in Computational Chemistry to join our dynamic and collaborative discovery team. This is a hands-on, individual contributor role - you will lead cutting-edge computational chemistry efforts, roll up your sleeves to generate design hypotheses and deliver actionable insights, while influencing program strategy and scientific direction. Whether you join as an Associate Principal or Principal level depends on your years of experience and track record. In either case, you will play a key role in advancing our discovery pipeline from target assessment through candidate nomination, partnering with medicinal chemistry, structural biology, biophysics, and biology teams. Key Responsibilities * Serve as the primary computational chemistry contributor on one or more drug discovery programs - designing, executing and interpreting computational workflows to support hit identification, hit-to-lead, and lead optimization. * Integrate structure- and ligand-based design, cheminformatics, predictive modeling and molecular simulation to propose novel compounds and drive progression of small-molecule therapeutics (including molecular glues/degraders). * Translate SAR, structural and modeling data into innovative design hypotheses; prioritize compounds and support decision-making alongside drug discovery teams. * Collaborate cross-functionally with medicinal chemistry, structural biology, biophysics, and biology to impact program strategy, compound design and project milestones. * Develop, optimize and deploy computational tools, workflows and methods (e.g., docking, MD, free energy calculations, ML/AI-driven design) to enhance our internal capabilities and accelerate discovery. * Present scientific results and strategic recommendations to internal project teams and senior leadership; provide mentorship and scientific guidance to less-experienced colleagues (without direct line-management responsibility). * Stay abreast of emerging computational chemistry technologies, apply deep domain knowledge and help shape the future of our computational capability. Required Qualifications Associate Principal Scientist level: * PhD in Computational Chemistry, Theoretical Chemistry, or a related field with 6+ years, MS with 9+ years, or BS with 12+ years of relevant industry experience in drug discovery. Principal Scientist level: * Ph.D. in Computational Chemistry, Theoretical Chemistry, Chemistry or related field with 8+ years, M.S. with 11+ years or B.S. with 14+ years of relevant industry experience. For both levels: * Demonstrated hands-on experience in small-molecule drug discovery, with proven ability to apply molecular modeling, docking, free energy calculations, QSAR/ML, and cheminformatics to support compound design and progression. * Strong record of working independently and delivering high-quality scientific work, while also collaborating effectively in cross-functional teams. * Proficiency with commercial and/or open source computational chemistry and molecular modeling software (e.g., Schrödinger, OpenEye, AMBER, GROMACS, etc.), and fluency in scripting/programming (e.g., Python, R). * Excellent communication and collaboration skills, with ability to influence project teams and senior leadership through scientific insight. * Self-starter attitude, willing to roll up sleeves and execute hands-on work while contributing strategically. * Please note: This role is not a people-manager/line-management position - it is a senior individual contributor role, intended for a strong computational scientist who thrives doing the work directly and influencing through scientific leadership rather than managerial oversight. Base salary range for Associate Principal Scientist is $167,000 ‒ $198,000 Base salary range for the Principal Scientist is: $187,000 - $240,000 Why Neomorph? At Neomorph, we believe scientific excellence thrives in an environment rooted in transparency, integrity, inclusivity, passion and flexibility. You'll join a growing team at the forefront of targeted protein degradation, where your contributions as an individual contributor will have significant impact on the company's discovery trajectory. What we offer: * Industry competitive compensation * Annual target bonus * Stock options * 401K plan * Career advancement opportunities * Monthly town halls to share business and scientific updates Work Hard, Stay Well * Comprehensive medical, dental, and vision plans for employees and their dependents * Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution * Employee Assistance Program * 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave. * Supplemental pay for Pregnancy Disability Leave * Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care Lifestyle * Casual work environment * Volunteer days off each year to spend time contributing to causes you care about * Flexible work schedule * Access to onsite gym * Onsite space to store your bicycle (or surfboard) Have Fun! We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day). About Us: Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against 'undruggable targets'. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. Neomorph is headquartered in San Diego, California. Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law. Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost. Job Description • The candidate will be a key member of the Ion Channel/GPCR/Transporter Pharmacology group, and provide experimental support for programs from target nomination through declaration of a clinical candidate. S/he will assist with the characterization of Client membrane targets, MoA studies and the development of HTS assays. • A MS degree with a minimum of 3 - 5 years of experience or a BS degree with a minimum of 4 - 8 years of laboratory experience is required. Hands- on expertise with plate-based assays, molecular biology, biochemistry, binding assays and cell culture techniques is essential. Working knowledge of ion channel, transporter or GPCR pharmacology is preferred. This position will be located in La Jolla, CA and may require up to 10% travel. Additional Information Best Regards, Anuj Mehta ************** Morristown, NJ 07960

Invivoscribe is an industry pioneer, dedicated to Improving Lives with Precision Diagnostics . Invivoscribe has been the global leader in driving international standardization of testing and accelerating patient access to the newest and best cancer treatments for over 30 years. Headquartered in sunny San Diego, California with locations across the world, we offer a comprehensive portfolio of products and services. We work with key collaborators to develop molecular assays, reagents, controls and bioinformatics tools under ISO 13485 design control that are used by over 700 clinical laboratories in over 160 countries. Our global network of laboratories offers internationally standardized next generation molecular and flow cytometry panels to support drug development and accelerate drug approvals worldwide. We work with pharmaceutical partners and international regulatory agencies across the globe to develop companion diagnostics, which are necessary to gain approval of new drugs and treatments for cancer patients. Our harmonized ISO15189 accredited and CLIA/CAP clinical laboratories offer a test menu focused on biomarkers which are clinically actionable to support therapeutic decisions, measurable residual disease (MRD) testing, patient stratification, and trial enrollment, all designed to accelerate approvals of new oncology drugs and treatments. For 30 years, we have been at forefront of precision diagnostics, and we're just getting started! We are looking to add a Senior Bioinformatics Scientist. The Senior Bioinformatics Scientist is a hands-on technical leader with advanced knowledge of scientific principles and concepts who designs, builds, and validates production-grade bioinformatics software and scalable NGS pipelines (on-prem and cloud) to diagnose and track disease (MRD) for clinical and research applications. This role independently identifies opportunities, defines technical roadmaps, and leads delivery from requirements and design through implementation, verification/validation, release, and lifecycle support. Core Responsibilities Include: Lead the design and development of bioinformatics software and pipelines to support Whole Genome Sequencing (WGS), hybrid-capture, and amplicon based NGS assays. Work in close collaboration with the R&D and clinical lab teams, representing bioinformatics from a technical leadership role. Evaluate and develop novel methods and external tools; perform benchmarking and method comparisons, and document recommendations and decisions; own projects end-to-end. Develop reproducible, testable bioinformatics software using modern engineering practices (git, code review, unit/integration tests, CI/CD, containerization), and workflow technologies (e.g., Nextflow). Apply deep Next Generation Sequencing (NGS) analytics expertise and partner with scientific stakeholders to translate bioinformatics outputs into actionable conclusions. Lead bioinformatics software development for CAP/CLIA/NYA environments, including requirements definition, design documentation, verification and validation planning/execution, traceability, change control, and release documentation. Provide technical leadership across cross-functional teams and influence others to raise team standards (R&D, clinical labs, QA/RA, DevOps). You Bring: Ph.D. degree in bioinformatics, computational biology, molecular biology, or related field with, typically, 8+ years applicable post-graduate experience. M.S. degree in bioinformatics or related field and 10+ years of applicable post-graduate experience. Equivalent combination of education and experience may be considered. Advanced proficiency with Linux and strong programming skills (Python, bash required; additional languages welcome). Experience building and/or leveraging AI agents and LLMs for various tasks and optimization of software development. Demonstrated experience designing and building production bioinformatics pipelines for WGS/WTS assays. Hands-on experience developing and operating bioinformatics software in the cloud, including workflow execution at scale and management of compute/storage costs. Experience collaborating across multi-disciplinary teams and providing technical leadership through influence (with or without direct reports). Strong foundation in statistics and quantitative analysis of biological datasets. Extensive background in immunology or cancer research is highly preferred. Experience developing software in a regulated environment is a plus (e.g. IVD, IVDR, CAP/CLIA/NYS). Proficient computer skills and good working knowledge of Microsoft Office programs and collaboration tools (Word, Outlook, Teams, Excel and PowerPoint) and the ability to learn new software programs. We Bring: A beautiful modern facility centrally located in San Diego County, with many jobs conducive to flexible scheduling and telework options. A welcoming breakroom for gathering with hosted hot/cold beverages and healthy convenience foods, and an available micro-market to get you through the day. A positive workplace culture with an emphasis on support, respect and belonging. A diverse and inclusive work environment where you will learn, grow, and make new friends. Competitive pay, discretionary bonus program, incentive stock options, generous benefit options, 401k with a fully vested employer match, and generous time off benefits. Invivoscribe is an Equal Opportunity Employer.

Qualifications: • General knowledge of Biology, Immunology, Flow Cytometry or other related discipline. • Familiarity with operation of routine laboratory instruments. • Effective oral and written communication skills. • Effective interpersonal skills. • Effective analytical and problem solving skills. • Demonstrated ability to to follow established policies and procedures. • Demonstrated ability to interpret and present data of simple to moderate complexity. • Demonstrated ability to keep accurate and complete laboratory records and logs. • Previous experience with Flow Cytometry and related software is a plus. Education and Experience: • Minimum Bachelor's degree in a biological science discipline • Minimum 0-2 years of relevant experience Responsibilities: The Scientist I is responsible for assisting in the development and evaluation of new reagents and enhancements to existing reagents. Executes experiments independently and evaluates and discusses data. Presents and explains material of simple to moderate complexity and prepares protocols and other documents. Has job skill and technical knowledge to perform established procedures. Under general supervision, plans, designs and performs reagent development activities. Work focus includes areas of Immunology, Cell Biology and Stem Cells using techniques such as multi-parameter flow cytometery, cell stimulation and cell culture assays. Direction is defined jointly with supervisor to meet short and mid-term goals. This position will regularly work with human and laboratory animal tissues. Primary duties include the following: • Performs experiments to evaluate new reagents using flow cytometer.. • Prepares protocols, reports and summaries. • Tabulates and analyzes experimental dat Qualifications Minimum Bachelor's degree in a biological science discipline Additional Information College degree or HS Diploma with +5 years biopharmaceutical industry experience

A leading biopharmaceutical company in San Diego is seeking a highly motivated Principal Scientist to lead therapeutic programs in biotherapeutics. The ideal candidate must possess expertise in high-throughput biologics screening and have a solid foundation in protein sciences and antibody discovery. Key responsibilities include advancing biologics projects, partnering with functional areas, and mentoring a small team of scientists. The role requires excellent communication skills and a strong track record in drug discovery. #J-18808-Ljbffr

A global health care leader in San Diego is seeking an experienced scientist to lead biologics discovery and development. The role includes designing innovative biologics, mentoring a team, and driving projects from discovery to IND-enabling studies. Candidates should have strong knowledge in therapeutic protein design and a relevant degree with extensive experience. A comprehensive benefits package is included, along with competitive salary range between $156,900.00 and $247,000.00. #J-18808-Ljbffr

A global healthcare leader in San Diego seeks a highly motivated scientist to contribute to the discovery and development of biotherapeutics. The role involves discovering and optimizing antibodies, utilizing flow cytometry, and requires strong skills in molecular biology and biochemistry. Ideal candidates should have significant industry experience and be detail-oriented, with excellent communication skills. Competitive compensation and benefits include a flexible benefits package and bonus potential. #J-18808-Ljbffr

The Postdoctoral Scientist in the Sharma Lab at Cedars-Sinai Regenerative Medicine Institute conducts advanced research using human induced pluripotent stem cells, CRISPR technology, and cardiac organoids to study cardiovascular diseases and drug toxicities. The role includes designing experiments, data analysis, mentoring, and contributing to publications under the guidance of the principal investigator. This position focuses on cutting-edge regenerative medicine with potential applications in cardiac disease modeling, drug toxicity prediction, and space biology. Job Description Join Dr. Arun Sharma and his research group as a Postdoctoral Scientist in the Cedars-Sinai Regenerative Medicine Institute! The Sharma Laboratory at Cedars-Sinai Medical Center, Regenerative Medicine Institute is looking for personnel to join our new and dynamic group. The mission of the Board of Governors Regenerative Medicine Institute aims to prevent and treat the world's most prevalent diseases through cell revitalization and transplantation. Work in the laboratory of Arun Sharma, PhD, focuses on applying human induced pluripotent stem cells (hi PSCs) to model cardiovascular diseases in vitro. The lab utilizes cutting-edge technologies, including hi PSCs, CRISPR/Cas9 genome editing, cardiac microfluidic organ-chips and cardiac organoids in our studies. Specifically, we have used hi PSC-derived cardiomyocytes (heart muscle cells) to model cardiac viral infections during COVID-19, examine developmental mechanisms underlying congenital heart disease and understand ways to alleviate cardiac toxicity caused by cancer drugs. In our ongoing studies, we have a unique background and interest in space biology, notably exploring ways in which stem cell biology can intersect with this emerging field. To learn more, please visit Sharma Research Lab | Cedars-Sinai. Are you ready to be a part of breakthrough research? Under the direction of Dr. Arun Sharma, the incumbent will be a part of a new collaborative project recently funded by ARPA-H, on the topic of predictive modeling of drug toxicities using pluripotent stem cells. The Postdoctoral Scientist may develop, adapt, and implement new research techniques and protocols, and will analyze, compile, and interpret data. Primary Job Duties and Responsibilities: May assist in preparation of grant proposals, submissions, publications and presentations but is not responsible for generating grant funds. Participate in publications and presentations as author or co-author. Designs and performs experiments, especially in regards to stem cell culture. Keeps appropriate experimental records and documentation and analyze the results with the Co-Principal Investigator. May mentor/train research associates, technicians, and students. Participation in laboratory meetings, keeping a lab notebook, performing calculations, tabulating data, summarizing methods and results of related experiments, and general lab maintenance. Operates and maintains equipment and instruments. Qualifications Education: • Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization. Experience and Skills: Acquires technical and theoretical knowledge of research project and objectives during one to fiveyear post-doctoral appointment. Works independently on research projects designed by a mentor (typically the PI) within area of specialization. Demonstrated skills to perform experimental protocols and procedures, including detailed data collection, and analysis. Experienced in research animal husbandry and handling. Scheduling flexibility including evening, weekend and holiday rotation commitment may be necessary. Travel may be required. Function efficiently and cooperatively with a team of faculty, research associates, technicians, and students. Excellent written and oral communication skills are essential. Knowledge of safety standards and maintenance of specialized equipment. About UsCedars-Sinai is a leader in providing high-quality healthcare encompassing primary care, specialized medicine and research. Since 1902, Cedars-Sinai has evolved to meet the needs of one of the most diverse regions in the nation, setting standards in quality and innovative patient care, research, teaching and community service. Today, Cedars- Sinai is known for its national leadership in transforming healthcare for the benefit of patients. Cedars-Sinai impacts the future of healthcare by developing new approaches to treatment and educating tomorrow's health professionals. Additionally, Cedars-Sinai demonstrates a commitment to the community through programs that improve the health of its most vulnerable residents. About the TeamCedars-Sinai is one of the largest nonprofit academic medical centers in the U.S., with 886 licensed beds, 2,100 physicians, 2,800 nurses and thousands of other healthcare professionals and staff. Choose this if you want to work in a fast-paced environment that offers the highest level of care to people in the Los Angeles that need our care the most. Req ID : 12755 Working Title : Postdoctoral Scientist - Sharma Lab - Regenerative Medicine Institute Department : Research - RMI Business Entity : Cedars-Sinai Medical Center Job Category : Academic / Research Job Specialty : Postdoctoral Scholar Overtime Status : EXEMPT Primary Shift : Day Shift Duration : 8 hour Base Pay : $62,400.00 - $93,600.00 Keywords: postdoctoral scientist, regenerative medicine, stem cell research, human induced pluripotent stem cells, cardiovascular disease modeling, CRISPR genome editing, cardiac organoids, drug toxicity prediction, biomedical research, space biology

Neomorph is seeking a highly experienced and strategically minded Associate Principal Scientist or Principal Scientist in Computational Chemistry to join our dynamic and collaborative discovery team. This is a hands-on, individual contributor role - you will lead cutting-edge computational chemistry efforts, roll up your sleeves to generate design hypotheses and deliver actionable insights, while influencing program strategy and scientific direction. Whether you join as an Associate Principal or Principal level depends on your years of experience and track record. In either case, you will play a key role in advancing our discovery pipeline from target assessment through candidate nomination, partnering with medicinal chemistry, structural biology, biophysics, and biology teams. Key Responsibilities Serve as the primary computational chemistry contributor on one or more drug discovery programs - designing, executing and interpreting computational workflows to support hit identification, hit-to-lead, and lead optimization. Integrate structure- and ligand-based design, cheminformatics, predictive modeling and molecular simulation to propose novel compounds and drive progression of small-molecule therapeutics (including molecular glues/degraders). Translate SAR, structural and modeling data into innovative design hypotheses; prioritize compounds and support decision-making alongside drug discovery teams. Collaborate cross-functionally with medicinal chemistry, structural biology, biophysics, and biology to impact program strategy, compound design and project milestones. Develop, optimize and deploy computational tools, workflows and methods (e.g., docking, MD, free energy calculations, ML/AI-driven design) to enhance our internal capabilities and accelerate discovery. Present scientific results and strategic recommendations to internal project teams and senior leadership; provide mentorship and scientific guidance to less-experienced colleagues (without direct line-management responsibility). Stay abreast of emerging computational chemistry technologies, apply deep domain knowledge and help shape the future of our computational capability. Required Qualifications Associate Principal Scientist level: PhD in Computational Chemistry, Theoretical Chemistry, or a related field with 6+ years, MS with 9+ years, or BS with 12+ years of relevant industry experience in drug discovery. Principal Scientist level: Ph.D. in Computational Chemistry, Theoretical Chemistry, Chemistry or related field with 8+ years, M.S. with 11+ years or B.S. with 14+ years of relevant industry experience. For both levels: Demonstrated hands-on experience in small-molecule drug discovery, with proven ability to apply molecular modeling, docking, free energy calculations, QSAR/ML, and cheminformatics to support compound design and progression. Strong record of working independently and delivering high-quality scientific work, while also collaborating effectively in cross-functional teams. Proficiency with commercial and/or open source computational chemistry and molecular modeling software (e.g., Schrödinger, OpenEye, AMBER, GROMACS, etc.), and fluency in scripting/programming (e.g., Python, R). Excellent communication and collaboration skills, with ability to influence project teams and senior leadership through scientific insight. Self-starter attitude, willing to roll up sleeves and execute hands-on work while contributing strategically. Please note: This role is not a people-manager/line-management position - it is a senior individual contributor role, intended for a strong computational scientist who thrives doing the work directly and influencing through scientific leadership rather than managerial oversight. Base salary range for Associate Principal Scientist is $167,000 ‒ $198,000 Base salary range for the Principal Scientist is: $187,000 - $240,000 Why Neomorph? At Neomorph, we believe scientific excellence thrives in an environment rooted in transparency, integrity, inclusivity, passion and flexibility. You'll join a growing team at the forefront of targeted protein degradation, where your contributions as an individual contributor will have significant impact on the company's discovery trajectory. What we offer: Industry competitive compensation Annual target bonus Stock options 401K plan Career advancement opportunities Monthly town halls to share business and scientific updates Work Hard, Stay Well Comprehensive medical, dental, and vision plans for employees and their dependents Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution Employee Assistance Program 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave. Supplemental pay for Pregnancy Disability Leave Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care Lifestyle Casual work environment Volunteer days off each year to spend time contributing to causes you care about Flexible work schedule Access to onsite gym Onsite space to store your bicycle (or surfboard) Have Fun! We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day). About Us: Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets'. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. Neomorph is headquartered in San Diego, California. Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law. Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.